clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-53.9
401
scaffold
stringlengths
0
100
CN(Cc1ccccc1CNC(=O)c1ccncn1)C(=O)Cc1nncn1C
CP000912599361
-28.09
O=C(Cc1nnc[nH]1)NCc1ccccc1CNC(=O)c1ccncn1
Cc1cc(C)cc(C(=O)NC(C)CCCNC(=O)c2oc(CC3CC3)nc2C)c1
CP000099509493
-26.56
O=C(NCCCCNC(=O)c1cnc(CC2CC2)o1)c1ccccc1
CNc1nnc(CC(=O)N2CC(=C(F)CNC(=O)C3CCC(=O)N3C)C2)s1
CP001771642354
-13.69
O=C1CCC(C(=O)NCC=C2CN(C(=O)Cc3nncs3)C2)N1
C[C@@H](NC(=O)c1c[nH]c2cc(Cl)ccc12)C1CN(c2nccn3nnnc23)C1
CP000453725061
-26.32
O=C(NCC1CN(c2nccn3nnnc23)C1)c1c[nH]c2ccccc12
O=C(NC(Cc1ccccc1)C1CC1)C(=O)N1CCC(COC2CCNC2)CC1
CP000293859309
1.81
O=C(NC(Cc1ccccc1)C1CC1)C(=O)N1CCC(COC2CCNC2)CC1
O=C1CCC(C(=O)NC[C@H]2C[C@H](NC(=O)C3CCCCS3(=O)=O)C2)=NN1
CP002519785506
-19.15
O=C1CCC(C(=O)NC[C@H]2C[C@H](NC(=O)C3CCCCS3(=O)=O)C2)=NN1
Cc1ccc(F)c(CC(=O)N2C[C@H](C)[C@H](NC(=O)C3(c4ccccn4)CC3)C2)c1
CP000087169289
-28.32
O=C(Cc1ccccc1)N1CC[C@H](NC(=O)C2(c3ccccn3)CC2)C1
CO[C@@H](C(=O)N1CC[C@H](NC(=O)C2(c3ncccc3F)CC2)C1)c1ccccc1
CP000372602596
-18.27
O=C(Cc1ccccc1)N1CC[C@H](NC(=O)C2(c3ccccn3)CC2)C1
O=C(NCC1CCCC2(CN(C(=O)C3(C4CC4)CC3)C2)O1)C1CC2CC1C1CC21
CP000143773802
null
O=C(NCC1CCCC2(CN(C(=O)C3(C4CC4)CC3)C2)O1)C1CC2CC1C1CC21
Cc1c(C(=O)N2CCC[C@H]2CNC(=O)CCc2ccc(=O)[nH]c2)noc1C1CC1
CP000117965199
-12.94
O=C(CCc1ccc(=O)[nH]c1)NC[C@@H]1CCCN1C(=O)c1cc(C2CC2)on1
Cc1cc(OCC(=O)NCCCOCCNC(=O)C2=CCCO2)no1
CP003067427350
-20.35
O=C(COc1ccon1)NCCCOCCNC(=O)C1=CCCO1
CCN(Cc1cnn(C)c1)c1nnc(-c2ccc(C)o2)n1CC(C)SC
CP001515892511
-20.31
c1coc(-c2nnc(NCc3cn[nH]c3)[nH]2)c1
CCN(Cc1cnn(C)c1)c1nnc(-c2ccco2)n1CC(C)(C)C(F)(F)F
CP000479996516
-18.78
c1coc(-c2nnc(NCc3cn[nH]c3)[nH]2)c1
Cc1ccc(-c2nnc(N(C)Cc3cnn(C)c3)n2CCCNC(=O)C(C)C)o1
CP000293581711
-17.61
c1coc(-c2nnc(NCc3cn[nH]c3)[nH]2)c1
CC1(C)CN(C(=O)C2CC3CCCC32)CC2(CN(c3ncnc4[nH]ccc34)C2)O1
CP000281056324
null
O=C(C1CC2CCCC21)N1CCOC2(C1)CN(c1ncnc3[nH]ccc13)C2
O=C(CN1CCCCC(NC(=O)c2cocn2)C1)NC(=O)Nc1ccccc1
CP000543644233
-13.4
O=C(CN1CCCCC(NC(=O)c2cocn2)C1)NC(=O)Nc1ccccc1
Cc1ncc(C)c(N2CCC(C)(CNC(=O)C3(Cc4ccccc4)CC3)CC2)n1
CP000302780941
-31.22
O=C(NCC1CCN(c2ccncn2)CC1)C1(Cc2ccccc2)CC1
Cc1cc(N2CCC(CN(C)C(=O)C3(Cc4ccccc4)CC3)CC2)nc(C)n1
CP000278068110
-30.62
O=C(NCC1CCN(c2ccncn2)CC1)C1(Cc2ccccc2)CC1
CSc1nccc(N2CCC(CNC(=O)C3(Cc4ccccc4)CC3)CC2)n1
CP000483768465
-27.25
O=C(NCC1CCN(c2ccncn2)CC1)C1(Cc2ccccc2)CC1
Cc1nc(O)cc(N2CCC(CN(C)C(=O)C3(Cc4ccccc4)CC3)CC2)n1
CP000278068123
-24.49
O=C(NCC1CCN(c2ccncn2)CC1)C1(Cc2ccccc2)CC1
Cc1ccc(CCC(=O)N2CC([C@@H](C)NC(=O)CCc3cncs3)C2)c(C)c1
CP000792156721
-27.51
O=C(CCc1cncs1)NCC1CN(C(=O)CCc2ccccc2)C1
CC(Cc1cccc(F)c1)C(=O)N1CC(CNC(=O)CCc2cncs2)C1
CP002447776592
-20
O=C(CCc1cncs1)NCC1CN(C(=O)CCc2ccccc2)C1
Cc1cc(C(=O)N2CC(C)C(NC(=O)C3CCSCC3)C2)sn1
CP003492401576
-21.69
O=C(NC1CCN(C(=O)c2ccns2)C1)C1CCSCC1
Cc1cccc(C(=O)NC2CCN(C(=O)C3CCc4[nH]c(O)nc4C3)C(C)C2)c1
CP000253298781
-24.81
O=C(NC1CCN(C(=O)C2CCc3[nH]cnc3C2)CC1)c1ccccc1
COC(=O)c1ccc(N[C@@H]2CCN(C(=O)c3cccc4c(C)n[nH]c34)C2)nc1
CP000482712018
-33.7
O=C(c1cccc2cn[nH]c12)N1CC[C@@H](Nc2ccccn2)C1
CNC(=O)N1CCC(C(=O)NC2(CC(=O)OC)CCOC2)CC1
CP001546472609
-19.94
O=C(NC1CCOC1)C1CCNCC1
CC1(NC(=O)C2CCN(CCNC(=O)OC(C)(C)C)CC2)CCOC1
CP001155243655
-14.5
O=C(NC1CCOC1)C1CCNCC1
CCN(C(=O)C1CCN(OC)CC1)C1CCOC1
CP000613234645
-1.81
O=C(NC1CCOC1)C1CCNCC1
CCCCS(=O)(=O)N1CCC(C(=O)NC2(CC(=O)O)CCOC2)CC1
CP001216500047
null
O=C(NC1CCOC1)C1CCNCC1
COC(=O)CCC1(NC(=O)C2CCN(S(=O)(=O)N(C)C)CC2)CCOC1
CP001050755378
null
O=C(NC1CCOC1)C1CCNCC1
CC(C)Cn1cccc(C(=O)NCCn2cc(-c3nccs3)nn2)c1=O
CP001271738187
-27.93
O=C(NCCn1cc(-c2nccs2)nn1)c1ccc[nH]c1=O
CCc1nc(C#N)cc(N2CCN(C)C(CNC(=O)C=CCN3CCCC3)C2)n1
CP000281794686
-19.89
O=C(C=CCN1CCCC1)NCC1CN(c2ccncn2)CCN1
Cc1nc(N(CCNC(=O)c2conc2C)C2CC2)c2cn[nH]c2n1
CP002389139021
-23.21
O=C(NCCN(c1ncnc2[nH]ncc12)C1CC1)c1cnoc1
O=C1CN(C=Cc2ccccc2)C(=O)N1CCC1SCCS1
CP000318393084
-28.9
O=C1CN(C=Cc2ccccc2)C(=O)N1CCC1SCCS1
CCC(C)C(=O)N1C[C@@H]2CCCN(C(=O)c3ccc(OC4CC4)cc3)[C@@H]2C1
CP002004251461
null
O=C(c1ccc(OC2CC2)cc1)N1CCC[C@H]2CNC[C@H]21
C[C@H](C(=O)N1C[C@@H]2CCCN(C(=O)c3ccc(OC4CC4)cc3)[C@@H]2C1)N(C)C
CP000911677374
null
O=C(c1ccc(OC2CC2)cc1)N1CCC[C@H]2CNC[C@H]21
Cc1cnc(N2CCC(CNC(=O)c3ccc(F)cn3)(C3CC3)C2)nc1
CP002224429464
-33.97
O=C(NCC1(C2CC2)CCN(c2ncccn2)C1)c1ccccn1
CC(C)(O)c1cnc(N2CCC(CNC(=O)c3ccc(F)cn3)(C3CC3)C2)nc1
CP000289783638
-32.58
O=C(NCC1(C2CC2)CCN(c2ncccn2)C1)c1ccccn1
Cc1cccc(C(=O)NCC2(C3CC3)CCN(c3ncc(C(F)F)cn3)C2)n1
CP000459919718
-30.22
O=C(NCC1(C2CC2)CCN(c2ncccn2)C1)c1ccccn1
Cc1ccnc(N2CCC(CNC(=O)c3ncccc3F)(C3CC3)C2)n1
CP002224437922
-29.6
O=C(NCC1(C2CC2)CCN(c2ncccn2)C1)c1ccccn1
Cc1cnc(N2CCC(CNC(=O)c3ccc(N(C)C)cn3)(C3CC3)C2)nc1
CP000459964895
-29.51
O=C(NCC1(C2CC2)CCN(c2ncccn2)C1)c1ccccn1
Cc1cccc(C(=O)NCC2(C3CC3)CCN(c3ncc(C)c(O)n3)C2)n1
CP001461274932
-29.45
O=C(NCC1(C2CC2)CCN(c2ncccn2)C1)c1ccccn1
Cc1cnc(N2CCC(CNC(=O)c3ccc(C(N)=O)cn3)(C3CC3)C2)nc1O
CP000289798330
-26.53
O=C(NCC1(C2CC2)CCN(c2ncccn2)C1)c1ccccn1
Cc1cccnc1CCCNC(=O)Nc1scnc1C1CC1
CP002176528733
-24.66
O=C(NCCCc1ccccn1)Nc1scnc1C1CC1
COc1cccc(C(O)C(=O)N2CCC(Nc3ncnc4scc(C)c34)C2)c1
CP000503457247
-30.81
O=C(Cc1ccccc1)N1CCC(Nc2ncnc3sccc23)C1
Cc1cccc(C(O)C(=O)N2CC(Nc3ncnc4sccc34)C(C)(C)C2)c1
CP000419370871
-29.56
O=C(Cc1ccccc1)N1CCC(Nc2ncnc3sccc23)C1
Cc1cccc(CC(=O)N2CC(C)C(Nc3ncnc4scc(C)c34)C2)c1
CP001439911719
-28.94
O=C(Cc1ccccc1)N1CCC(Nc2ncnc3sccc23)C1
Cc1ccoc1C(=O)N1CCCC2(NC(=O)c3coc4c3COC4)CCCC12
CP000763469799
null
O=C(NC12CCCC1N(C(=O)c1ccco1)CCC2)c1coc2c1COC2
CC(C)(C)c1noc(CN2CCCC2C2CCN(C(=O)[C@@H]3CCCO3)CC2)n1
CP000496433682
-19.7
O=C([C@@H]1CCCO1)N1CCC(C2CCCN2Cc2ncno2)CC1
O=C(NC1CC(Nc2cc(O)ncn2)C12CCOCC2)c1ocnc1C(F)F
CP000453820117
null
O=C(NC1CC(Nc2ccncn2)C12CCOCC2)c1cnco1
CCO[C@H]1C[C@H](n2cc(C3CCN(C(=O)c4ccccc4CO)C3)nn2)C1
CP001174663810
-19.14
O=C(c1ccccc1)N1CCC(c2cn(C3CCC3)nn2)C1
CC(CNC(=O)c1cccc2cccc(O)c12)CNC(=O)C12COC(CCO1)C2
CP000230940856
-24.18
O=C(NCCCNC(=O)C12COC(CCO1)C2)c1cccc2ccccc12
Cc1oncc1C(=O)N1CCCC2(CNC(=O)C(F)c3ccccc3)CCCC12
CP000056966127
-21.39
O=C(Cc1ccccc1)NCC12CCCC1N(C(=O)c1cnoc1)CCC2
CC1OC(C)C(C(=O)N2CCC[C@H](NC(=O)COCc3cccnc3)C2)C1C
CP001137826283
-16.28
O=C(COCc1cccnc1)N[C@H]1CCCN(C(=O)C2CCOC2)C1
Cc1ncc(C(=O)NC2CC(CNC(=O)C=C3CCN(C)C3)C2)c(C(C)C)n1
CP000891607411
-25
O=C(C=C1CCNC1)NCC1CC(NC(=O)c2cncnc2)C1
CC1(NC(=O)C2CC3(CC(O)C3)C2)CCN(c2nc(C3CC3)ns2)C1
CP002399103769
-22.58
O=C(NC1CCN(c2nc(C3CC3)ns2)C1)C1CC2(CCC2)C1
O=C(NCC1CCN(C(=O)[C@@H]2CCc3ccccc32)CC1)c1ccc(=O)[nH]c1
CP001010828257
-30.24
O=C(NCC1CCN(C(=O)[C@@H]2CCc3ccccc32)CC1)c1ccc(=O)[nH]c1
Cc1nc(C(=O)NC2COCCN(C(=O)c3cc(C)c(C)o3)C2)cs1
CP003242716054
-25.65
O=C(NC1COCCN(C(=O)c2ccco2)C1)c1cscn1
Cc1nc(C(=O)NC2COCCN(C(=O)c3ccc(F)o3)C2)cs1
CP003390293945
-25.61
O=C(NC1COCCN(C(=O)c2ccco2)C1)c1cscn1
CCc1nc(C(=O)NC2COCCN(C(=O)c3ccc(C#N)o3)C2)cs1
CP002789032566
-23.67
O=C(NC1COCCN(C(=O)c2ccco2)C1)c1cscn1
COc1ccc(C(=O)N(C)CC2CCN(C(=O)c3oc(C4CC4)nc3C)C2)cc1
CP000225620439
-31.41
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
Cc1nc(C2CC2)oc1C(=O)N1CCC(CNC(=O)c2cc(C#N)ccc2O)C1
CP000306145368
-28.18
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
Cc1ccc(O)cc1C(=O)NC(C)C1CCN(C(=O)c2oc(C3CC3)nc2C)C1
CP000262903654
-28.02
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
CCc1cc(C(=O)NCC2(C)CCN(C(=O)c3cnc(C4CC4)o3)C2)ccc1O
CP000089326714
-27.13
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccc(CF)cc1
CP002316932924
-26.05
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
CC1CC(CNC(=O)c2cc(N)ccc2O)CN1C(=O)c1cnc(C2CC2)o1
CP001079126554
-25.8
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
CN(C)c1cccc(C(=O)NCC2(C)CCN(C(=O)c3cnc(C4CC4)o3)C2)c1
CP000089326336
-24.55
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
COc1ccc(F)cc1C(=O)NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1
CP001244638939
-23.99
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1cccc(O)c1
CP002870825948
-23.05
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
CN(CC1CCN(C(=O)c2cnc(C3CC3)o2)C1)C(=O)c1cccc(O)c1F
CP001134874997
-21.56
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
CC1CC(CNC(=O)c2cccc(F)c2O)CN1C(=O)c1cnc(C2CC2)o1
CP001079126635
-20.93
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
CC(O)c1ccccc1C(=O)NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1
CP001244639610
-20.73
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
COc1ccc(C)cc1C(=O)NCC1CN(C(=O)c2cnc(C3CC3)o2)CC1C
CP000263983942
-18.46
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
CC1CN(C(=O)c2cnc(C3CC3)o2)CC1CNC(=O)c1ccc(CC#N)cc1
CP000263984117
-14.91
O=C(NCC1CCN(C(=O)c2cnc(C3CC3)o2)C1)c1ccccc1
C=CCC1(C(=O)N2CC(N3CC(NC(=O)C(C)C4CCOC4)CC3=O)C2)CC1
CP001184163419
-16.65
O=C(CC1CCOC1)NC1CC(=O)N(C2CN(C(=O)C3CC3)C2)C1
COCC1(C(=O)N2CC(N3CC(NC(=O)CC4CCOC4)CC3=O)C2)CC1
CP002323443443
-9.61
O=C(CC1CCOC1)NC1CC(=O)N(C2CN(C(=O)C3CC3)C2)C1
C[C@H]1C[C@@H]1C(=O)N1CC(N2CC(NC(=O)C(C)(C)C3(O)CCOC3)CC2=O)C1
CP001184149170
null
O=C(CC1CCOC1)NC1CC(=O)N(C2CN(C(=O)C3CC3)C2)C1
CCn1nccc1C=CC(=O)N1CCC(CNC(=O)c2ncccn2)C1(C)C
CP000593967830
-21.81
O=C(NCC1CCN(C(=O)C=Cc2ccn[nH]2)C1)c1ncccn1
CC(C)(C)c1ncc(C(=O)N2CCC2CNC(=O)COc2ccsn2)cn1
CP001703253061
-18.8
O=C(COc1ccsn1)NCC1CCN1C(=O)c1cncnc1
CN(CCOCCNC(=O)C=C1CCC1)C(=O)c1cc2c(s1)CC(C)(C)C2
CP001837758803
-17.74
O=C(C=C1CCC1)NCCOCCNC(=O)c1cc2c(s1)CCC2
Cc1nc(C(=O)NCC(C)NC(=O)C2CCCc3[nH]nnc32)[nH]c1C
CP003316831497
-22.88
O=C(NCCNC(=O)C1CCCc2[nH]nnc21)c1ncc[nH]1
Cn1nnnc1N1CC[C@H](NC(=O)c2ccc(C(C)(C)C)s2)C1
CP002903410695
-29.64
O=C(N[C@H]1CCN(c2nnn[nH]2)C1)c1cccs1
CC1CCN(C(=O)C(=O)N(CCNC(=O)C2CCCSC2)C2CC2)CC1
CP002889245767
-11.86
O=C(NCCN(C(=O)C(=O)N1CCCCC1)C1CC1)C1CCCSC1
Cc1ccc(CCC(=O)NC2CN(C(=O)c3cnsc3C)CC2(C)C)o1
CP002538060231
-30.74
O=C(CCc1ccco1)NC1CCN(C(=O)c2cnsc2)C1
CCN(C(=O)CC(C)c1ccco1)C1CCN(C(=O)c2csnc2OC)C1
CP002266088887
-23.33
O=C(CCc1ccco1)NC1CCN(C(=O)c2cnsc2)C1
O=C(NC1COC2(C1)CN(C(=O)C1CC1F)C2)C1CC2(CC(O)C2)C1
CP003091294616
-11.54
O=C(NC1COC2(C1)CN(C(=O)C1CC1)C2)C1CC2(CCC2)C1
CCOC1CC1C(=O)N1CC2(CC(NC(=O)C3CC4(CCC4)C3)CO2)C1
CP002696084235
-7.7
O=C(NC1COC2(C1)CN(C(=O)C1CC1)C2)C1CC2(CCC2)C1
NC(=O)NC1(C(=O)N2CC3(CC(NC(=O)C4(F)CC5(CCC5)C4)CO3)C2)CC1
CP000957913585
null
O=C(NC1COC2(C1)CN(C(=O)C1CC1)C2)C1CC2(CCC2)C1
CC(C)C1(C)CC1C(=O)N1CC2(CC(NC(=O)C3CC4(CC(O)C4)C3)CO2)C1
CP000957915293
null
O=C(NC1COC2(C1)CN(C(=O)C1CC1)C2)C1CC2(CCC2)C1
Cc1noc(CN2CCCCC(NC(=O)c3c[nH]nc3-c3ccccc3)C2)n1
CP000543760930
-14.96
O=C(NC1CCCCN(Cc2ncno2)C1)c1c[nH]nc1-c1ccccc1
COc1ncc(NC(=O)C2Cc3c(O)cccc3N2)cc1Br
CP002172723057
-26.51
O=C(Nc1cccnc1)C1Cc2ccccc2N1
CCCOc1cncc(NC(=O)C2Cc3c(cccc3OC)N2)c1
CP001325488703
-25.87
O=C(Nc1cccnc1)C1Cc2ccccc2N1
Cc1cc(F)c2c(c1)NC(C(=O)Nc1ccc(OCCO)nc1)C2
CP001327144100
-25.03
O=C(Nc1cccnc1)C1Cc2ccccc2N1
COc1ccc(F)c2c1CC(C(=O)Nc1ccc(C(C)C)nc1)N2
CP001325675102
-7.98
O=C(Nc1cccnc1)C1Cc2ccccc2N1
Cc1cc(C(=O)NC(C)CCNC(=O)c2coc(C(C)C)n2)c2c(n1)CCCC2
CP000310193800
-28.18
O=C(NCCCNC(=O)c1ccnc2c1CCCC2)c1cocn1
CCc1ocnc1C(=O)NCC(O)CNC(=O)c1cc(C)nc2c1CCCC2
CP001199059836
-25.9
O=C(NCCCNC(=O)c1ccnc2c1CCCC2)c1cocn1
O=C(NCc1cnc(-c2ccccc2)s1)N1CC2(C1)CC2(F)F
CP001560480076
-25.8
O=C(NCc1cnc(-c2ccccc2)s1)N1CC2(CC2)C1
COc1cc(C)cnc1C(=O)NC1CCN(c2ncnc(N)n2)CC1F
CP002221802072
-33.01
O=C(NC1CCN(c2ncncn2)CC1)c1ccccn1
Cc1cnc(C(=O)NC2CCN(c3nc(N)nc(C(F)F)n3)CC2C)cc1C
CP000474044400
-32.36
O=C(NC1CCN(c2ncncn2)CC1)c1ccccn1
CCCN(C(=O)c1cc(C)c(C(N)=O)cn1)C1CCN(c2ncnc(N)n2)CC1
CP000296952815
-31.32
O=C(NC1CCN(c2ncncn2)CC1)c1ccccn1