clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
CCn1c(C(=O)NCC(C2CC2)N(C)C(=O)C(C)(C)C2CC2)cnc1O
CP002529265901
-16.15
O=C(CC1CC1)NC(CNC(=O)c1cnc[nH]1)C1CC1
O=C1CCCN1CC(=O)N1C2CCC1CN(C(=O)c1ccsc1)CC2
CP003289075273
null
O=C1CCCN1CC(=O)N1C2CCC1CN(C(=O)c1ccsc1)CC2
CC1(C)C(NC(=O)C23CCOC2CCOC3)CCN1c1nc(C2CC2)ns1
CP001448511174
-20.41
O=C(NC1CCN(c2nc(C3CC3)ns2)C1)C12CCOC1CCOC2
CCc1c[nH]c(C(=O)NCc2cnn3c2CN(C(=O)c2cnn(C)c2)CC3)c1
CP000790694428
-32.36
O=C(NCc1cnn2c1CN(C(=O)c1cn[nH]c1)CC2)c1ccc[nH]1
Cc1[nH]ncc1C(=O)N1CCn2ncc(CNC(=O)c3ccc(C(N)=O)[nH]3)c2C1
CP000092955113
-30.01
O=C(NCc1cnn2c1CN(C(=O)c1cn[nH]c1)CC2)c1ccc[nH]1
OC1(c2nc(-c3cnc4ccccc4c3)no2)CCCN(Cc2ccccc2)C1
CP000060431757
-30.9
c1ccc(CN2CCCC(c3nc(-c4cnc5ccccc5c4)no3)C2)cc1
CC(C)(C)OC(=O)N1CCC12CCN(C(=O)COc1ccc(F)cc1F)CC2
CP000386025117
-20.87
O=C(COc1ccccc1)N1CCC2(CCN2)CC1
COCc1cc(CNC(=O)NCC2(CO)CC2c2ccccc2)no1
CP001563309527
-25.52
O=C(NCc1ccon1)NCC1CC1c1ccccc1
CNc1ccc(C(=O)N2CCC[C@H]2CN(C)C(=O)Cc2sccc2C)nc1
CP001745215935
-34.56
O=C(Cc1cccs1)NC[C@@H]1CCCN1C(=O)c1ccccn1
O=C(Cc1ccc(Cl)s1)NC[C@@H]1CCCN1C(=O)c1cccc(F)n1
CP003018050989
-30.01
O=C(Cc1cccs1)NC[C@@H]1CCCN1C(=O)c1ccccn1
N#Cc1ccc(C(=O)N2C[C@@H](F)C[C@H]2CNC(=O)Cc2cccs2)nc1
CP002580427890
-27.07
O=C(Cc1cccs1)NC[C@@H]1CCCN1C(=O)c1ccccn1
Cc1csc(CC(=O)NC[C@@H]2C[C@H](F)CN2C(=O)c2ncccc2F)c1
CP002581526282
-26.75
O=C(Cc1cccs1)NC[C@@H]1CCCN1C(=O)c1ccccn1
Cc1ccc(C(=O)N2CCC[C@H]2CN(C)C(=O)C(C)c2cccs2)nc1F
CP001662381001
-26.01
O=C(Cc1cccs1)NC[C@@H]1CCCN1C(=O)c1ccccn1
Cc1ccc(C(C)C(=O)NC[C@@H]2CCCN2C(=O)c2ncccc2O)s1
CP002578415343
-13.39
O=C(Cc1cccs1)NC[C@@H]1CCCN1C(=O)c1ccccn1
O=C(N[C@H]1C[C@@H](NC(=O)C2CCc3cncn3C2)C1)c1noc2c1CCCCC2
CP000341927385
-44.41
O=C(N[C@H]1C[C@@H](NC(=O)C2CCc3cncn3C2)C1)c1noc2c1CCCCC2
CCN(CCCNC(=O)CC1CC2(CC2)C1)C(=O)c1cnc2n1CCCCC2
CP001023826675
-27.47
O=C(CC1CC2(CC2)C1)NCCCNC(=O)c1cnc2n1CCCCC2
Cc1nc(CCC(=O)NCCCNC(=O)Cc2cn3c(n2)CCCC3)cs1
CP002330830046
-46.29
O=C(CCc1cscn1)NCCCNC(=O)Cc1cn2c(n1)CCCC2
C[C@H]1CN(C(=O)c2c[nH]c3cc(N)ccc23)CCN1C(=O)C1(C)CCCCO1
CP001259344763
-24.94
O=C(c1c[nH]c2ccccc12)N1CCN(C(=O)C2CCCCO2)CC1
CC(NC(=O)c1cccn2nncc12)C1CN(C(=O)c2ccsc2)CCO1
CP001995522062
-27.28
O=C(NCC1CN(C(=O)c2ccsc2)CCO1)c1cccn2nncc12
CC(C(=O)N1CCCC(NC(=O)c2ccon2)CC1)N1CCc2ccccc21
CP001109992863
-18.99
O=C(NC1CCCN(C(=O)CN2CCc3ccccc32)CC1)c1ccon1
CC(CS(=O)(=O)NC(=O)C1COC2(CCNCC2)C1)C1CC1
CP002189111994
-26.42
O=C(NS(=O)(=O)CCC1CC1)C1COC2(CCNCC2)C1
Cc1nc(CC2CC2)oc1C(=O)N1CCN(C(=O)C23CC2C3)C2(CCC2)C1
CP002159790593
-22.15
O=C(c1cnc(CC2CC2)o1)N1CCN(C(=O)C23CC2C3)C2(CCC2)C1
CC(CCCNC(=O)CCC1CCCOC1)NC(=O)[C@@H]1CSCC(=O)N1
CP002523465198
-23.8
O=C(CCC1CCCOC1)NCCCCNC(=O)[C@@H]1CSCC(=O)N1
Cc1cc(C)c(C=CC(=O)N2CCOC(CNC(=O)C3=CCCCO3)C2)cc1C
CP000231423394
-25.12
O=C(NCC1CN(C(=O)C=Cc2ccccc2)CCO1)C1=CCCCO1
O=C(NCC1(Nc2cc(C3CC3)ncn2)COC1)c1cn[nH]c1-c1ccco1
CP000457835153
-26.44
O=C(NCC1(Nc2cc(C3CC3)ncn2)COC1)c1cn[nH]c1-c1ccco1
O=C(NCC1CC2CCC1N(C(=O)c1ccno1)C2)c1ccncc1Cl
CP002359136615
-28.97
O=C(NCC1CC2CCC1N(C(=O)c1ccno1)C2)c1ccncc1
CCC1(C(=O)N2CC(Nc3ncc4[nH]cnc4n3)C2)CCCC1
CP002909211004
-29.93
O=C(C1CCCC1)N1CC(Nc2ncc3[nH]cnc3n2)C1
Cn1cnc2nc(NC3CN(C(=O)C4(S(C)(=O)=O)CCCC4)C3)nc(O)c21
CP001365851314
-17.53
O=C(C1CCCC1)N1CC(Nc2ncc3[nH]cnc3n2)C1
Cc1[nH]cnc1CC(=O)NCC1CCCC2(CN(C(=O)C3COC(=O)C3)C2)O1
CP001006630161
-44.05
O=C(Cc1c[nH]cn1)NCC1CCCC2(CN(C(=O)C3COC(=O)C3)C2)O1
N#Cc1ccc(C(=O)N2CC(O)(CNC(=O)c3ccc(-n4cnnn4)cc3)C2)[nH]1
CP000091200047
-41.35
O=C(NCC1CN(C(=O)c2ccc[nH]2)C1)c1ccc(-n2cnnn2)cc1
CCC1(C)CCC(C(=O)N(C)C(C)CNC(=O)C2COC(=O)C2)O1
CP003435863798
-28.52
O=C1CC(C(=O)NCCNC(=O)C2CCCO2)CO1
CC1CC(C)C(C(=O)NCC(C)N(C)C(=O)C2COC(=O)C2)O1
CP003494775910
-19.96
O=C1CC(C(=O)NCCNC(=O)C2CCCO2)CO1
COCCN(CCNC(=O)C1(CO)CCCO1)C(=O)C1COC(=O)C1
CP003076788918
-16.64
O=C1CC(C(=O)NCCNC(=O)C2CCCO2)CO1
CN(CCNC(=O)C1COC(=O)C1)C(=O)C1CCCO1
CP001492941949
-16.37
O=C1CC(C(=O)NCCNC(=O)C2CCCO2)CO1
CC1CCN(C(=O)Cc2cnn(C)c2)CC1CNC(=O)c1cnn(CC2CC2)c1
CP000081484021
-21.37
O=C(NCC1CCCN(C(=O)Cc2cn[nH]c2)C1)c1cnn(CC2CC2)c1
Cc1cc(CCC(=O)NCC2C3CN(C(=O)CCc4ccccn4)CC23)[nH]n1
CP001075342795
-27.21
O=C(CCc1ccn[nH]1)NCC1C2CN(C(=O)CCc3ccccn3)CC12
CN(C(=O)c1cnoc1C1CCC1)C1CCN(c2nc(C(C)(C)C)ns2)C1
CP001479422096
-22.99
O=C(NC1CCN(c2ncns2)C1)c1cnoc1C1CCC1
CN(CC1CCCN(C(=O)C2C=CCC2)C1)C(=O)c1c[nH]cc1-c1ccccc1
CP000338350712
-26.82
O=C(NCC1CCCN(C(=O)C2C=CCC2)C1)c1c[nH]cc1-c1ccccc1
O=C(NC12CCCC1N(C(=O)Cc1cnoc1)CC2)C1=CCCOCC1
CP002533523243
-20.84
O=C(NC12CCCC1N(C(=O)Cc1cnoc1)CC2)C1=CCCOCC1
COCCN(CCNC(=O)C1(n2ccnn2)CC1)C(=O)Cc1cnc(C)s1
CP001637533652
-23.11
O=C(Cc1cncs1)NCCNC(=O)C1(n2ccnn2)CC1
CC1(C)C(C)(C)C1(C)C(=O)N1CCC1CNC(=O)CCCCN1CCCC1
CP001703264601
null
O=C(CCCCN1CCCC1)NCC1CCN1C(=O)C1CC1
COc1ccc(C(=O)N[C@H]2CC[C@H](NC(=O)CCC3CCCN3C)CC2)nn1
CP001024576725
-45.67
O=C(CCC1CCCN1)N[C@H]1CC[C@H](NC(=O)c2cccnn2)CC1
CC(C)N(CCN(C)c1ncc2c(n1)COC2)C(=O)c1csc2ccccc12
CP000419663931
-23.6
O=C(NCCNc1ncc2c(n1)COC2)c1csc2ccccc12
C=C(C)CC(=O)N1CC2(C1)CN(C(=O)c1cnn3ncccc13)C2
CP003325872240
-24.22
O=C(c1cnn2ncccc12)N1CC2(CNC2)C1
O=C(Cn1cnnn1)N1CCCC(Nc2nccnc2F)C1
CP003468564648
-23.02
O=C(Cn1cnnn1)N1CCCC(Nc2cnccn2)C1
CC[C@H]1CC[C@H](C(=O)NCC2CC3(CC3)CN2C(=O)CC2(OC)CCC2)CC1
CP000757476671
-25.46
O=C(NCC1CC2(CC2)CN1C(=O)CC1CCC1)C1CCCCC1
COCC1(C(=O)NCC2CC3(CC3)CN2C(=O)C(C)C2CCC2)CCCCC1
CP000757822514
-21.16
O=C(NCC1CC2(CC2)CN1C(=O)CC1CCC1)C1CCCCC1
CCN(C)CC1CCN(C(=O)C(=O)Nc2ccc(-c3csnn3)cc2)CC1
CP001284590353
-45.63
O=C(Nc1ccc(-c2csnn2)cc1)C(=O)N1CCCCC1
O=C(Nc1ccc(-c2csnn2)cc1)C(=O)N1CCC[C@@H](O)C1
CP002892658756
-38.85
O=C(Nc1ccc(-c2csnn2)cc1)C(=O)N1CCCCC1
CC(C)(C)OC1CCCN(C(=O)C(=O)Nc2ccc(-c3csnn3)cc2)C1
CP001284665534
-32.59
O=C(Nc1ccc(-c2csnn2)cc1)C(=O)N1CCCCC1
N#CC(C#N)C1CCN(C(=O)C(=O)Nc2ccc(-c3csnn3)cc2)CC1
CP001284865631
-31.25
O=C(Nc1ccc(-c2csnn2)cc1)C(=O)N1CCCCC1
CCN(C(=O)CCCN1CCCC1)C1CCN(C(=O)c2nc(C)n(C)n2)C1
CP002266007651
-51.09
O=C(CCCN1CCCC1)NC1CCN(C(=O)c2nc[nH]n2)C1
CCN(C)CC(=O)NC1(CO)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003324329159
-32.6
O=C1OCC(C(=O)N2CCC2)CO1
CC=C(C)C(=O)NC(C)C1CN(C(=O)C2(C)COC(=O)OC2)C1
CP003495417688
-25.03
O=C1OCC(C(=O)N2CCC2)CO1
C[C@@H](NC(=O)C=CC(=O)N(C)C)C1CN(C(=O)C2(C)COC(=O)OC2)C1
CP002635495948
-23.88
O=C1OCC(C(=O)N2CCC2)CO1
C[C@H](CC(F)(F)F)C(=O)NC1(CO)CN(C(=O)C2(C)COC(=O)OC2)C1
CP002650621530
-22.15
O=C1OCC(C(=O)N2CCC2)CO1
CC(C)CC(C)C(=O)NCC1CN(C(=O)C2(C)COC(=O)OC2)C1
CP003425004518
-21.85
O=C1OCC(C(=O)N2CCC2)CO1
CCCC(C(=O)NC1(C)CN(C(=O)C2(C)COC(=O)OC2)C1)C(C)C
CP003236266611
-20.1
O=C1OCC(C(=O)N2CCC2)CO1
CSCCC(=O)NC1(CO)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003509790969
-18.33
O=C1OCC(C(=O)N2CCC2)CO1
C=CCC(=O)NC(C)CC1CN(C(=O)C2(C)COC(=O)OC2)C1
CP003511246556
-17.8
O=C1OCC(C(=O)N2CCC2)CO1
CC=CC=CC(=O)NC1(C)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003505351326
-17.46
O=C1OCC(C(=O)N2CCC2)CO1
COC1(CNC(=O)CCF)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003513508524
-17.4
O=C1OCC(C(=O)N2CCC2)CO1
C=CCC1(NC(=O)C(C)O)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003512121676
-17.32
O=C1OCC(C(=O)N2CCC2)CO1
CSC(C)CC(=O)NC1(C)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003505063103
-16.87
O=C1OCC(C(=O)N2CCC2)CO1
CCCC(NC(N)=O)C(=O)NC1(CO)CN(C(=O)C2(C)COC(=O)OC2)C1
CP001766458142
-16.54
O=C1OCC(C(=O)N2CCC2)CO1
CCC(C)CC(=O)NC1(C)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003505077223
-15.76
O=C1OCC(C(=O)N2CCC2)CO1
CC(C)SCC(=O)NC1(C)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003504979475
-15.75
O=C1OCC(C(=O)N2CCC2)CO1
CC(=O)N[C@@H](C(=O)NC(C)C1CN(C(=O)C2(C)COC(=O)OC2)C1)C(C)(C)C
CP001070931352
-15.42
O=C1OCC(C(=O)N2CCC2)CO1
CC1(C(=O)N2CC(OCCNC(=O)C=CC(N)=O)C2)COC(=O)OC1
CP003012202644
-15.12
O=C1OCC(C(=O)N2CCC2)CO1
CC(NC(=O)[C@H](NC(N)=O)C(C)C)C1CN(C(=O)C2(C)COC(=O)OC2)C1
CP001991390432
-15.07
O=C1OCC(C(=O)N2CCC2)CO1
C[C@@H](NC(=O)CC(F)(F)F)C1CN(C(=O)C2(C)COC(=O)OC2)C1
CP003392314139
-14.92
O=C1OCC(C(=O)N2CCC2)CO1
CCCC(=O)NCC1(OC)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003513326969
-14.36
O=C1OCC(C(=O)N2CCC2)CO1
CC1(C(=O)N2CC(CO)(NC(=O)C=C(Cl)Cl)C2)COC(=O)OC1
CP003510054002
-13.85
O=C1OCC(C(=O)N2CCC2)CO1
COCC(=O)NCCC1(O)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003506477741
-13.53
O=C1OCC(C(=O)N2CCC2)CO1
CC1(C(=O)N2CC(CNC(=O)C(C)(C)S(C)(=O)=O)C2)COC(=O)OC1
CP003153496996
-13.26
O=C1OCC(C(=O)N2CCC2)CO1
CON=CC(=O)N[C@@H](C)C1CN(C(=O)C2(C)COC(=O)OC2)C1
CP003508831325
-13.23
O=C1OCC(C(=O)N2CCC2)CO1
CC(NC(=O)CCCCO)C1(O)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003113743299
-13.23
O=C1OCC(C(=O)N2CCC2)CO1
CC(O)C(=O)NC(C)C1(O)CN(C(=O)C2(C)COC(=O)OC2)C1
CP003510312007
-8.99
O=C1OCC(C(=O)N2CCC2)CO1
CC1(C(=O)N2CC(O)(CCNC(=O)C(C)(C)C(C)(F)F)C2)COC(=O)OC1
CP002126255985
-7.96
O=C1OCC(C(=O)N2CCC2)CO1
CC(NS(C)(=O)=O)C(=O)NCC1CCN1C(=O)C1(C)COC(=O)OC1
CP003286270448
-7.08
O=C1OCC(C(=O)N2CCC2)CO1
CCc1nc(CC(=O)NC2(C)CCN(c3nc(CC4CC4)ns3)C2)cs1
CP001914344855
-23.88
O=C(Cc1cscn1)NC1CCN(c2nc(CC3CC3)ns2)C1
Cc1nc(N)[nH]c(=O)c1CC(=O)N[C@@H]1CCN(C(=O)c2cc[nH]c(=O)c2)C1
CP002334006739
-19.72
O=C(Cc1cnc[nH]c1=O)N[C@@H]1CCN(C(=O)c2cc[nH]c(=O)c2)C1
CSCCC(=O)NC1CC2CN(C(=O)C3(n4ccnn4)CC3)CC21
CP003388669458
-22.41
O=C(N1CC2CCC2C1)C1(n2ccnn2)CC1
CC(C)(C)CC(C)(C)C(=O)NC1CC2CN(C(=O)C3(n4ccnn4)CC3)CC21
CP000931714347
null
O=C(N1CC2CCC2C1)C1(n2ccnn2)CC1
CCn1cnc2c(N(C)CC3CCCN3C(=O)c3coc(CO)c3)ncnc21
CP000413863139
-29.1
O=C(c1ccoc1)N1CCCC1CNc1ncnc2[nH]cnc12
Cc1cnc(C(=O)N2CCC(NC(=O)CCn3ccc4cccnc43)C2)cn1
CP001239751580
-31.68
O=C(CCn1ccc2cccnc21)NC1CCN(C(=O)c2cnccn2)C1
CC12COC(C(=O)N3CCC4(CCC4)C(CNC(=O)c4ccsc4)C3)(C1)C2
CP002162799863
null
O=C(NCC1CN(C(=O)C23CC(CO2)C3)CCC12CCC2)c1ccsc1
Cc1nc2cc(C(=O)N[C@@H]3CCN(C(=O)c4c(C)coc4C)C3)[nH]c2s1
CP002817775118
-33
O=C(N[C@@H]1CCN(C(=O)c2ccoc2)C1)c1cc2ncsc2[nH]1
CCc1cn2c(C(=O)N[C@H](C)C3CN(C(=O)C4CCC(CC)O4)C3)cccc2n1
CP000094529208
-22.35
O=C(NCC1CN(C(=O)C2CCCO2)C1)c1cccc2nccn12
CN(c1nnc(C2CC2)n1CCCCCO)C1CCOC1
CP002554244771
-21.31
C1CC(Nc2nnc(C3CC3)[nH]2)CO1
CCOCCn1c(C2CC2)nnc1N(C)C1CCOC1
CP001487698969
-19.34
C1CC(Nc2nnc(C3CC3)[nH]2)CO1
Cc1cc(C(=O)NC[C@H]2C[C@H](Nc3ncnc4ccc(F)cc34)C2)cc(C)n1
CP000423755351
-27.43
O=C(NC[C@H]1C[C@H](Nc2ncnc3ccccc23)C1)c1ccncc1
Cc1ncc(Cl)c(C(=O)N2CC3(CN(C(=O)c4ccc(Cl)o4)C3)C2)n1
CP003115585637
-26.89
O=C(c1ccncn1)N1CC2(C1)CN(C(=O)c1ccco1)C2
O=C(c1cc(O)ncn1)N1CC2(C1)CN(C(=O)c1ccc(CO)o1)C2
CP003116194551
-23.16
O=C(c1ccncn1)N1CC2(C1)CN(C(=O)c1ccco1)C2
CC(CNC(=O)Cc1ccc(F)cn1)N(C)C(=O)CC12COC(C)(C1)C2
CP002633968980
-20.07
O=C(Cc1ccccn1)NCCNC(=O)CC12COC(C1)C2
Cc1cccc2c(C(=O)N[C@H](C)CNc3cccc(F)c3C#N)cnn12
CP002059204157
-27.17
O=C(NCCNc1ccccc1)c1cnn2ccccc12
CCN(CCNC(=O)c1cnn2cccc(Cl)c12)c1cccc(F)c1C#N
CP001473164162
-26.08
O=C(NCCNc1ccccc1)c1cnn2ccccc12
CC(C)c1cccc(C(=O)N[C@H]2CCN(CC#Cc3ccc(Cl)cc3)C2)n1
CP001381971014
-58.22
O=C(N[C@H]1CCN(CC#Cc2ccccc2)C1)c1ccccn1
CC(=Cn1ccnn1)C(=O)N1CCN(C(=O)C2(Cc3ccccc3)CC2)C[C@H]1C
CP000376130526
-28.28
O=C(C=Cn1ccnn1)N1CCN(C(=O)C2(Cc3ccccc3)CC2)CC1
Cn1cnn(CCC(=O)N2CCCC(NC(=O)C3CC4(CCC4)C3)C2)c1=O
CP002232634307
-23.47
O=C(NC1CCCN(C(=O)CCn2nc[nH]c2=O)C1)C1CC2(CCC2)C1