clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
O=C(Cc1ccc2oc(=O)[nH]c2c1)N1CC2CCC1CN2C(=O)CC1C=CCC1
CP000258455758
-22.64
O=C(Cc1ccc2oc(=O)[nH]c2c1)N1CC2CCC1CN2C(=O)CC1C=CCC1
CN1CCC(C(=O)N2CCCC(CNC(=O)c3cccnn3)CC2)CC1=O
CP001775803132
-27
O=C1CC(C(=O)N2CCCC(CNC(=O)c3cccnn3)CC2)CCN1
CC1(C)C2CCC1(C(=O)NCC(O)CNC(=O)C=Cc1ccsc1)CC2
CP002832964652
-37.83
O=C(C=Cc1ccsc1)NCCCNC(=O)C12CCC(CC1)C2
O=C(CC1(O)CCCOC1)N1CC2CC(C1)N(C(=O)c1cc(O)cc(O)n1)C2
CP000589784238
-17.06
O=C(CC1CCCOC1)N1CC2CC(C1)N(C(=O)c1ccccn1)C2
C[C@@]1(CNC(=O)C2(C(N)=O)CC2)CCCN1C(=O)C1(C2CCCO2)CCCC1
CP000584152348
-19.22
O=C(NCC1CCCN1C(=O)C1(C2CCCO2)CCCC1)C1CC1
CC(C)(C(=O)N[C@@H]1CCN(Cc2ccc(Cl)s2)C1)N1CCOCC1
CP003130279453
-44.36
O=C(CN1CCOCC1)N[C@@H]1CCN(Cc2cccs2)C1
CCn1nncc1C(=O)NC[C@@]1(C)CCCN1C(=O)c1ccc2ccccc2n1
CP000173660611
-27.95
O=C(NCC1CCCN1C(=O)c1ccc2ccccc2n1)c1cnn[nH]1
Cc1[nH]c(C#N)cc1C(=O)N1CCC(C)(NC(=O)C(C)NC(=O)c2ccco2)C1
CP000088484709
-27.25
O=C(CNC(=O)c1ccco1)NC1CCN(C(=O)c2cc[nH]c2)C1
Cc1[nH]ccc1C(=O)N1CCC(NC(=O)C(C)NC(=O)c2ccco2)C1(C)C
CP000680696861
-26.71
O=C(CNC(=O)c1ccco1)NC1CCN(C(=O)c2cc[nH]c2)C1
CC1CC(=O)CCC1C(=O)NC1CCCN(C(=O)CC(C)(O)C2CC2)C1
CP002730677719
-15.82
O=C1CCC(C(=O)NC2CCCN(C(=O)CCC3CC3)C2)CC1
Cc1ccnc2nc(C(=O)N[C@H]3CCN(C(=O)C=CC4CCOCC4)C3)nn12
CP001146615027
-24.37
O=C(N[C@H]1CCN(C(=O)C=CC2CCOCC2)C1)c1nc2ncccn2n1
CCN(CC(C)C)c1nnc(-c2ccc(C)o2)n1CC1(O)CCOC1C
CP001516024947
-25.56
c1coc(-c2nncn2CC2CCOC2)c1
CCC(C)CN(CC)c1nnc(-c2ccc(C)o2)n1CC1CCOC1
CP001573563241
-21.54
c1coc(-c2nncn2CC2CCOC2)c1
O=C1NC[C@H](C(=O)NC[C@H]2C[C@@H](NC(=O)c3cc(C(F)F)ncn3)C2)N1
CP002797928920
-22.27
O=C1NC[C@H](C(=O)NC[C@H]2C[C@@H](NC(=O)c3ccncn3)C2)N1
Cc1cc(N)ccc1C(=O)N1CCC1CNC(=O)c1c(Cl)oc2ccccc12
CP001213613341
-31.29
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
Cc1ccc2occ(C(=O)NCC3CCN3C(=O)c3ccc(C)c(C)c3)c2c1
CP001251309112
-30.4
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
COc1ccc2occ(C(=O)NCC3CCN3C(=O)c3cccc(N)c3N)c2c1
CP000177214092
-29.53
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
Cc1ccc2c(C(=O)NCC3CCN3C(=O)c3cc(F)ccc3C)coc2c1
CP001252425055
-29.44
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
O=C(NCC1CCN1C(=O)c1cccc(F)c1)c1coc2ccc(F)cc12
CP001702637495
-28.87
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
Cc1ccc(O)cc1C(=O)N1CCC1CNC(=O)c1c(Cl)oc2ccccc12
CP001213613316
-28.81
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
COc1ccc(O)c(C(=O)N2CCC2CNC(=O)c2coc3ccc(F)cc23)c1
CP000177080953
-28.6
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
Nc1ccc(Cl)cc1C(=O)N1CCC1CNC(=O)c1coc2ccccc12
CP002200072108
-28.47
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
COCc1ccccc1C(=O)N1CCC1CNC(=O)c1coc2cc(C)ccc12
CP000141837309
-28.44
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
CNc1ccc(C(=O)N2CCC2CNC(=O)c2coc3cc(C)c(C)cc23)cc1
CP000177149125
-27.56
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
O=C(NCC1CCN1C(=O)c1ccccc1O)c1coc2ccccc12
CP002991217150
-25.64
O=C(NCC1CCN1C(=O)c1ccccc1)c1coc2ccccc12
Cc1cc(C(=O)NCCNc2ncnc3ccsc23)ccc1Cl
CP002899646645
-33.65
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CC(CNc1ncnc2ccsc12)N(C)C(=O)c1ccc(NC(N)=O)cc1
CP001483319658
-32.44
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CCC(CNC(=O)c1ccc(C)c(C)c1)Nc1ncnc2ccsc12
CP002392261049
-31.77
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CON=Cc1ccc(C(=O)N[C@H](C)CNc2ncnc3c(C)csc23)cc1
CP001430878526
-31.41
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CCc1nc(N[C@@H](CO)CNC(=O)c2c(C)cccc2C)c2scc(C)c2n1
CP000456001097
-30.64
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
COc1ccc(C(=O)NCC(C)Nc2nc(Cl)nc3cc(C)sc23)cc1
CP002045232033
-30.38
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1cc(Cl)ccc1C(=O)N(C)CCNc1ncnc2ccsc12
CP002382371085
-30.03
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
C[C@@H](CNc1ncnc2ccsc12)NC(=O)c1cccc([S+](C)[O-])c1
CP002396873662
-29.97
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
COc1cccc(C(=O)NC(C)CN(C)c2ncnc3ccsc23)c1OC
CP001431432916
-29.75
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1cc(F)c(C(=O)NC[C@H](CO)Nc2ncnc3c(C)csc23)c(F)c1
CP001457135805
-29.37
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
COc1cc(C(=O)NCC(C)Nc2ncnc3ccsc23)ccc1Cl
CP002386800231
-29.18
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CC(=O)Nc1c(C)cccc1C(=O)NC[C@@H](C)Nc1ncnc2ccsc12
CP001464331820
-29.16
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1csc2c(N(C)C(C)CNC(=O)c3cccc(N(C)C)c3)ncnc12
CP001443060710
-28.71
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1cc(C(=O)NC[C@@H](C)Nc2ncnc3c(C)csc23)c(F)cc1F
CP002226528929
-28.51
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1cccc(Cl)c1C(=O)N(C)CCNc1ncnc2ccsc12
CP002382371813
-28.5
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CN(CCNc1ncnc2ccsc12)C(=O)c1ccccc1C(C)(F)F
CP002049231584
-28.35
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1nc(NC(C)CNC(=O)c2cccc(C)c2F)c2scc(C)c2n1
CP002045280590
-28.33
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
C=Cc1ccc(C(=O)NCC(C)N(C)c2ncnc3c(C)csc23)cc1
CP001919972053
-27.95
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
COc1ccc(C(=O)N(C)CCNc2nc(C)nc3c(C)csc23)cc1F
CP001474882348
-27.61
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1csc2c(NCCNC(=O)c3cccc(C[S+](C)[O-])c3)ncnc12
CP001519205806
-27.57
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CC(CN(C)C(=O)c1cccc(C#CCO)c1)Nc1ncnc2ccsc12
CP001354371533
-27.11
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
COc1ccc(OC)c(C(=O)NCC(C)N(C)c2ncnc3ccsc23)c1
CP001443075102
-26.99
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1nc(N[C@@H](CO)CNC(=O)c2ccc(C)c(C)c2)c2scc(C)c2n1
CP001456999017
-26.9
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CCN(CCNC(=O)c1cccc(C(F)F)c1)c1ncnc2ccsc12
CP002047340009
-26.86
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CC(CN(C)c1ncnc2ccsc12)NC(=O)c1cccc(F)c1F
CP002397010627
-26.46
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
O=C(NC[C@H](CO)Nc1ncnc2ccsc12)c1cccc(F)c1Cl
CP002462216895
-26.08
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1csc2c(NC(C)CN(C)C(=O)c3cccc(CO)c3)ncnc12
CP001923203649
-26.02
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CC(C)(CNC(=O)c1ccc(OCC(N)=O)cc1)Nc1ncnc2ccsc12
CP000442223825
-25.95
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
COc1cc(C(=O)N(C)CC(C)Nc2ncnc3c(C)csc23)ccc1C
CP001354096632
-25.92
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1ccc(C(=O)N(C)CCNc2nc(C)nc3c(C)csc23)c(F)c1
CP002048884105
-25.64
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
COc1ccc(C(=O)NCC(C)Nc2ncnc3c(C)csc23)c(OC)c1
CP001470704093
-25.59
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CN(CC(C)(C)Nc1ncnc2ccsc12)C(=O)c1ccccc1
CP002927547599
-25.36
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
CCN(CCNC(=O)c1ccccc1[S+](C)[O-])c1ncnc2ccsc12
CP002047474231
-21.29
O=C(NCCNc1ncnc2ccsc12)c1ccccc1
Cc1ncc(Cl)c(C(=O)N2CCOC(CN(C)C(=O)CCC3(C)CC3)C2)n1
CP001718620447
-22.52
O=C(CCC1CC1)NCC1CN(C(=O)c2ccncn2)CCO1
Cc1cc(C(=O)N2CCOC(CNC(=O)CC(C)(C)C3CC3)C2)nc(O)n1
CP001947576287
-16.03
O=C(CCC1CC1)NCC1CN(C(=O)c2ccncn2)CCO1
Nc1ccc(Cl)c(C(=O)NCC(NC(=O)C23CC2C3)C2CCCCC2)c1
CP002822150527
-27.31
O=C(NCC(NC(=O)C12CC1C2)C1CCCCC1)c1ccccc1
N#Cc1ccc(C(=O)NCC(NC(=O)C23CC2C3)C2CCCCC2)c(F)c1
CP002083973275
-27.01
O=C(NCC(NC(=O)C12CC1C2)C1CCCCC1)c1ccccc1
CN(CC1CCN(C(=O)C23CC(C2)C3)CC1)C(=O)c1cc(C(F)(F)F)ncn1
CP001136933404
-35.66
O=C(NCC1CCN(C(=O)C23CC(C2)C3)CC1)c1ccncn1
Cc1ncc(Cl)c(C(=O)NCC2CCN(C(=O)C34CC(C3)C4)CC2)n1
CP003266826949
-25.96
O=C(NCC1CCN(C(=O)C23CC(C2)C3)CC1)c1ccncn1
CCN(CCNC(=O)c1cccc2c1CCN2)C(=O)c1cc(-c2ccco2)[nH]n1
CP000321558835
-29.36
O=C(NCCNC(=O)c1cccc2c1CCN2)c1cc(-c2ccco2)[nH]n1
CN(CCCNc1ncnc2c1CCC2)C(=O)CNC(=O)N1CCCC1
CP002060389891
-27.11
O=C(CNC(=O)N1CCCC1)NCCCNc1ncnc2c1CCC2
C=C1CC1C(=O)N1CCCCC(Nc2ncnc3c2nnn3CC2CC2)C1
CP001450068551
-24.82
C=C1CC1C(=O)N1CCCCC(Nc2ncnc3c2nnn3CC2CC2)C1
c1coc(CN(CCN2CCOCC2)CC2CCC3(CCCCCC3)O2)c1
CP000528528576
-26.38
c1coc(CN(CCN2CCOCC2)CC2CCC3(CCCCCC3)O2)c1
CSc1cc(C(=O)NCCC2(CNc3ncnc4c3CCC4)CC2)c(C)o1
CP001358947315
-28.46
O=C(NCCC1(CNc2ncnc3c2CCC3)CC1)c1ccoc1
CC1(C)C(C(=O)N2CC(CO)(NC(=O)C3CCc4ccccc4O3)C2)C1(C)C
CP000845546544
-25.55
O=C(NC1CN(C(=O)C2CC2)C1)C1CCc2ccccc2O1
C=CCC1(NC(=O)C2CCc3ccccc3O2)CN(C(=O)[C@@H]2CC2(F)F)C1
CP001849991941
-25.23
O=C(NC1CN(C(=O)C2CC2)C1)C1CCc2ccccc2O1
CC(C(=O)N1C2CCC1CN(C(=O)CCC1CCC(=O)NC1)CC2)=C1CC1
CP002206787434
null
O=C1CCC(CCC(=O)N2CCC3CCC(C2)N3C(=O)C=C2CC2)CN1
O=C(NCCN(c1ncc(C(F)F)cn1)C1CC1)C1CCCc2ncnn21
CP001474731937
-30.85
O=C(NCCN(c1ncccn1)C1CC1)C1CCCc2ncnn21
CN1CCN(CC(=O)NCC2(F)CC(Nc3nc4cccc(F)c4o3)C2)CC1
CP000428455034
-52.04
O=C(CN1CCNCC1)NCC1CC(Nc2nc3ccccc3o2)C1
CCc1c[nH]cc1C(=O)N1CC2C(CNC(=O)c3ccn4ccccc34)C2C1
CP001074568778
-25.16
O=C(NCC1C2CN(C(=O)c3cc[nH]c3)CC12)c1ccn2ccccc12
O=C(NCC1CCN1C(=O)CC1CCc2ccccc2N1)C1Cc2ccccc21
CP000177165872
-27.73
O=C(NCC1CCN1C(=O)CC1CCc2ccccc2N1)C1Cc2ccccc21
COCc1nnc(S(=O)(=O)Cc2ccc(OCc3ccc(F)cc3)cc2)[nH]1
CP001283264255
-34.06
O=S(=O)(Cc1ccc(OCc2ccccc2)cc1)c1nnc[nH]1
CC1=NN(C)C(=O)C1CC(=O)NC[C@H]1CCCN1C(=O)Cn1cnc(C#N)n1
CP000602110413
-17.95
O=C(CC1C=NNC1=O)NC[C@H]1CCCN1C(=O)Cn1cncn1
CCOc1cccc(C=CC(=O)NCC2=CCN(C(=O)C34CC3C4)CC2)c1
CP001641958481
-24.41
O=C(C=Cc1ccccc1)NCC1=CCN(C(=O)C23CC2C3)CC1
Cc1cc2ncc(NC(=O)NCc3cc(C(F)F)on3)cn2n1
CP001552046390
-33.79
O=C(NCc1ccon1)Nc1cnc2ccnn2c1
COC(=O)c1cnn2c1CN(C(=O)NCc1cccc3c1CCCN3)CC2
CP001293171536
-31.98
O=C(NCc1cccc2c1CCCN2)N1CCn2nccc2C1
Cc1nc(C(=O)NCC2(Nc3cc4nnc(C)n4cn3)CCOCC2)co1
CP001436251399
-24.82
O=C(NCC1(Nc2cc3nncn3cn2)CCOCC1)c1cocn1
CC(C)C[C@@H](Cn1cc(-c2cncnc2)nn1)NC(=O)c1c[nH]nc1C1CC1
CP000242024688
-22.4
O=C(NCCn1cc(-c2cncnc2)nn1)c1c[nH]nc1C1CC1
CC(C)(C)c1noc(Cn2nnnc2N2CCC(F)(C(F)(F)F)CC2)n1
CP002348543323
-31.78
c1noc(Cn2nnnc2N2CCCCC2)n1
CCS(=O)(=O)C1CCN(c2nnnn2Cc2nc(C)no2)CC1
CP003351712083
-29.83
c1noc(Cn2nnnc2N2CCCCC2)n1
CCOC(=O)C1CCN(c2nnnn2Cc2nc(CSC)no2)CC1
CP002421965078
-28.27
c1noc(Cn2nnnc2N2CCCCC2)n1
CC(C)CCC1CCN(c2nnnn2Cc2nc(C(C)(C)C)no2)CC1
CP002348543192
-27.67
c1noc(Cn2nnnc2N2CCCCC2)n1
CC(C)(C)c1noc(Cn2nnnc2N2CCC(S(N)(=O)=O)CC2)n1
CP002421965406
-26.58
c1noc(Cn2nnnc2N2CCCCC2)n1
CCc1noc(Cn2nnnc2N2CCC(C(C)C)CC2)n1
CP003479152654
-26.57
c1noc(Cn2nnnc2N2CCCCC2)n1
CCC1(C(=O)OC(C)(C)C)CCCN(c2nnnn2Cc2nc(C)no2)C1
CP001586416998
-26.41
c1noc(Cn2nnnc2N2CCCCC2)n1
CCCCC1CCCN(c2nnnn2Cc2nc(COC)no2)C1
CP003135929553
-23.3
c1noc(Cn2nnnc2N2CCCCC2)n1
Cc1noc(Cn2nnnc2N2CCCC(CC(C)C)C2)n1
CP003479056283
-23.13
c1noc(Cn2nnnc2N2CCCCC2)n1
CSCc1noc(Cn2nnnc2N2CCC(CC(F)(F)F)CC2)n1
CP002421965137
-21.91
c1noc(Cn2nnnc2N2CCCCC2)n1
CCc1noc(Cn2nnnc2N2CCC(OC)C(C)C2)n1
CP003479152735
-21.47
c1noc(Cn2nnnc2N2CCCCC2)n1
COCc1noc(Cn2nnnc2N2CCC(C(=O)OC)(C(F)F)CC2)n1
CP001586663345
-21.35
c1noc(Cn2nnnc2N2CCCCC2)n1
CNS(=O)(=O)C1CCN(c2nnnn2Cc2nc(COC)no2)CC1
CP002422031244
-19.71
c1noc(Cn2nnnc2N2CCCCC2)n1
CCc1occc1C(=O)N1CC([C@@H](C)NC(=O)c2ccn3ccnc3n2)C1
CP002146484514
-27.06
O=C(NCC1CN(C(=O)c2ccoc2)C1)c1ccn2ccnc2n1
CCn1ccc(C(=O)NCC2CCCCN(C(=O)C3CC34CC(C)(C)C4)C2)n1
CP000816098386
-28.72
O=C(NCC1CCCCN(C(=O)C2CC23CCC3)C1)c1cc[nH]n1
CC1(CNC(=O)c2cc3ncccn3n2)CCCN(Cc2cscn2)C1
CP002341608427
-42.78
O=C(NCC1CCCN(Cc2cscn2)C1)c1cc2ncccn2n1
O=C(NC1CCCCCN(C(=O)C2CCC2)C1)[C@H]1Cc2ccccc2N1
CP002802289653
null
O=C(NC1CCCCCN(C(=O)C2CCC2)C1)[C@H]1Cc2ccccc2N1