clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
CN1C(=O)C(=O)N(CC(=O)N2CCC(NC(=O)[C@H]3CCC(=O)O3)C2)C1=O
CP002984561564
-23.58
O=C1CC[C@H](C(=O)NC2CCN(C(=O)CN3C(=O)NC(=O)C3=O)C2)O1
CC(=O)c1cnc(N2C3CCC2CN(C(=O)C2CN(C)C(=O)N2)C3)c(C)c1
CP001475667834
-21.41
O=C1NCC(C(=O)N2CC3CCC(C2)N3c2ccccn2)N1
CN(c1cnc(F)cn1)C1CCN(C(=O)C2CCN(C3CCCCC3)C2)CC1
CP000438777729
-57.74
O=C(C1CCN(C2CCCCC2)C1)N1CCC(Nc2cnccn2)CC1
Cc1ccc2cc(C(=O)N3CC4C(CNC(=O)c5cnco5)C4C3)cnc2c1
CP001074208815
-25.57
O=C(NCC1C2CN(C(=O)c3cnc4ccccc4c3)CC12)c1cnco1
O=C(NC[C@H]1CCN(C(=O)CCn2cncn2)C1)c1cc2occc2s1
CP003005367568
-32.82
O=C(NC[C@H]1CCN(C(=O)CCn2cncn2)C1)c1cc2occc2s1
CC(NC(=O)c1cn[nH]c1)C1CN(C(=O)CCc2ccsc2)C1
CP003495385785
-26.65
O=C(NCC1CN(C(=O)CCc2ccsc2)C1)c1cn[nH]c1
COC(=O)C1(OC)CCN(C(=O)Nc2cc(F)ccc2OCC2CCCO2)C1
CP000406138566
-25.71
O=C(Nc1ccccc1OCC1CCCO1)N1CCCC1
Cc1ccc(NC(=O)N2CCC[C@H]2CS(N)(=O)=O)c(OCC2CCCO2)c1
CP000520044043
-24.14
O=C(Nc1ccccc1OCC1CCCO1)N1CCCC1
O=C(NC1CC2CCC1N(C(=O)CCCC1CC1)C2)c1ccn2ccnc2c1
CP000646172200
-21.83
O=C(NC1CC2CCC1N(C(=O)CCCC1CC1)C2)c1ccn2ccnc2c1
CN(Cc1cccc(C(F)(F)F)c1)C(=O)C(=O)N1CCC2(CC1)CC(N)CO2
CP000480811984
-46.46
O=C(NCc1ccccc1)C(=O)N1CCC2(CCCO2)CC1
CN(Cc1cccc(O)c1)C(=O)C(=O)N1CCC2(CC1)CC(N)CO2
CP001575239225
-44.15
O=C(NCc1ccccc1)C(=O)N1CCC2(CCCO2)CC1
C[C@@H](NC(=O)C(=O)N1CCC2(CC1)CC(N)CO2)c1cccc(C#N)c1
CP001517275294
-43.48
O=C(NCc1ccccc1)C(=O)N1CCC2(CCCO2)CC1
COC(=O)C1COC2(CCN(C(=O)C(=O)NCc3ccc(C)cc3F)CC2)C1
CP000478167431
-30.28
O=C(NCc1ccccc1)C(=O)N1CCC2(CCCO2)CC1
Cc1ccc(CNC(=O)C(=O)N2CCC3(CCCO3)CC2)cc1F
CP002372240773
-29.06
O=C(NCc1ccccc1)C(=O)N1CCC2(CCCO2)CC1
Cc1ccc(C(C)NC(=O)C(=O)N2CCC3(CC2)CC(C(N)=O)CO3)cc1
CP001287805353
-27.06
O=C(NCc1ccccc1)C(=O)N1CCC2(CCCO2)CC1
CC=CC(=O)N1CCCC(C2CCN(C(=O)C3CCC4(CCC4)O3)C2)C1
CP002665243597
-27.13
O=C(C1CCC2(CCC2)O1)N1CCC(C2CCCNC2)C1
CC(NC(=O)C1CC12CCOC2)C1CN(Cc2ccnc(N(C)C)c2)C1
CP002345418948
-32.69
O=C(NCC1CN(Cc2ccncc2)C1)C1CC12CCOC2
CC(C)C(=O)N1CCC(C(=O)NOCCN2CCCC2=O)CC1
CP001530744943
-21.71
O=C(NOCCN1CCCC1=O)C1CCNCC1
O=C1CCC(N2CC[C@@H](NC(=O)c3cccnn3)C2)C(=O)N1
CP003477075584
-47.25
O=C1CCC(N2CC[C@@H](NC(=O)c3cccnn3)C2)C(=O)N1
O=C(c1cnccn1)N1CC2(CCN(C(=O)C3CCCS3)C2)C1
CP003507060239
-24.44
O=C(c1cnccn1)N1CC2(CCN(C(=O)C3CCCS3)C2)C1
CCc1nc(C)c(C(=O)NC2(CNC(=O)C3(C)COC(=O)OC3)CCCC2)o1
CP000973990634
-18.91
O=C1OCC(C(=O)NCC2(NC(=O)c3cnco3)CCCC2)CO1
Cc1cc(C(=O)N2CCC(N(C)Cc3nc(C4CC4)no3)C2)nn1C(C)C
CP001373550754
-26.25
O=C(c1cc[nH]n1)N1CCC(NCc2nc(C3CC3)no2)C1
CN(Cc1nc(C2CC2)no1)C1CCN(C(=O)c2nn(C)cc2Cl)C1
CP002408167887
-24.35
O=C(c1cc[nH]n1)N1CCC(NCc2nc(C3CC3)no2)C1
O=C(NCCCN(C(=O)C=Cc1ncc[nH]1)C1CC1)c1cnc(C2CC2)o1
CP001971966618
-53.11
O=C(NCCCN(C(=O)C=Cc1ncc[nH]1)C1CC1)c1cnc(C2CC2)o1
C[C@@]12CN(C(=O)c3ccc(-c4cc[nH]n4)s3)C[C@]1(C)CN(C1CCNC1=O)C2
CP000552888567
-28.21
O=C1NCCC1N1CC2CN(C(=O)c3ccc(-c4cc[nH]n4)s3)CC2C1
O=C1CC(CC(=O)N2C[C@@H]3CN(c4ncc(C(F)F)cn4)C[C@@H]3C2)CCCN1
CP000471052269
-23.24
O=C1CC(CC(=O)N2C[C@@H]3CN(c4ncccn4)C[C@@H]3C2)CCCN1
CC1(CCNC(=O)N2CCN(C3CCOC3)CC2)CN(C(=O)OC(C)(C)C)C1
CP000409292685
-40.34
O=C(NCCC1CNC1)N1CCN(C2CCOC2)CC1
CN(C)CC(=O)N1CC=CC(NC(=O)CCC2CC(C)(C)CO2)C1
CP003330647502
-42
O=C(CCC1CCCO1)NC1C=CCNC1
C[C@@H](C(=O)N1CC=CC(NC(=O)CCC2CC(C)(C)CO2)C1)N(C)C
CP003125928195
-39.06
O=C(CCC1CCCO1)NC1C=CCNC1
CCN(CC)CC(F)C(=O)N1CC=CC(NC(=O)CCC2CC(C)(C)CO2)C1
CP000752276836
-33.78
O=C(CCC1CCCO1)NC1C=CCNC1
CC(C)(C)CCCCC(=O)N1CC=CC(NC(=O)CCC2CCCO2)C1
CP002604410097
-31.99
O=C(CCC1CCCO1)NC1C=CCNC1
CC(=CC(=O)N1CC=CC(NC(=O)CCC2CCCO2)C1)C(C)(C)C
CP003125601854
-29.88
O=C(CCC1CCCO1)NC1C=CCNC1
CCOC(=O)CC(=O)N1CC=CC(NC(=O)CCC2CC(C)(C)CO2)C1
CP002604908580
-29.38
O=C(CCC1CCCO1)NC1C=CCNC1
COCC(C)C(=O)N1CC=CC(NC(=O)CCC2CCCO2)C1
CP003512878986
-29.28
O=C(CCC1CCCO1)NC1C=CCNC1
CCSCC(=O)N1CC=CC(NC(=O)CCC2CC(C)(C)CO2)C1
CP003330647517
-29.21
O=C(CCC1CCCO1)NC1C=CCNC1
COC(C)(C)C(=O)N1CC=CC(NC(=O)CCC2CCCO2)C1
CP003512879072
-27.6
O=C(CCC1CCCO1)NC1C=CCNC1
CC(C)CCC(=O)N1CC=CC(NC(=O)CCC2CCC(C)O2)C1
CP003330607710
-26.85
O=C(CCC1CCCO1)NC1C=CCNC1
CC(CC(=O)NC1C=CCN(C(=O)[C@@H](NC(N)=O)C(C)C)C1)C1CCCO1
CP001865134295
-23.32
O=C(CCC1CCCO1)NC1C=CCNC1
CCCC(CCC)CC(=O)N1CC=CC(NC(=O)CCC2CCC(C)O2)C1
CP001864886756
-21.78
O=C(CCC1CCCO1)NC1C=CCNC1
COCC(=O)N(C)CC(=O)N1CC=CC(NC(=O)CCC2CC(C)(C)CO2)C1
CP000752276943
-21.47
O=C(CCC1CCCO1)NC1C=CCNC1
CC(C(=O)N1CC(CO)C2(C1)CN(C(=O)c1cn[nH]c(=O)c1)C2)=C1CCCC1
CP000784501521
-20.1
O=C(C=C1CCCC1)N1CCC2(C1)CN(C(=O)c1cn[nH]c(=O)c1)C2
CC1(Cn2cc(C(=O)NCC(O)CNC(=O)Cc3cnoc3)nn2)COC1
CP002098444310
-24.37
O=C(Cc1cnoc1)NCCCNC(=O)c1cn(CC2COC2)nn1
Cc1cc(CC(=O)NC2CC3CCC(C2)N3C(=O)CCc2ccsc2)on1
CP002247108809
null
O=C(Cc1ccno1)NC1CC2CCC(C1)N2C(=O)CCc1ccsc1
COc1c(C)nc(C2CC2)nc1N1CCC(C)(NC(=O)c2ccncn2)CC1
CP000468589198
-26.24
O=C(NC1CCN(c2ccnc(C3CC3)n2)CC1)c1ccncn1
C=CCC1(NC(=O)c2ccnc(OC)n2)CCN(c2ccnc(C3CC3)n2)CC1
CP000245498137
-25.46
O=C(NC1CCN(c2ccnc(C3CC3)n2)CC1)c1ccncn1
COc1ccc2c(c1)CCCC(NC(=O)NC1CCC(C)(N(C)C)CC1)C2
CP000524735372
-38.16
O=C(NC1CCCCC1)NC1CCCc2ccccc2C1
COc1ccc2c(c1)CC(NC(=O)N[C@H]1CC[C@H](C)CC1)CCC2
CP002365592499
-30.02
O=C(NC1CCCCC1)NC1CCCc2ccccc2C1
Cc1ccccc1OCCC(=O)NC1COC2(CC2)C1
CP002484162763
-28.88
O=C(CCOc1ccccc1)NC1COC2(CC2)C1
Cc1cc(C(=O)NC(CNC(=O)c2ccccc2-c2ncn[nH]2)C2CC2)no1
CP000992216046
-27.83
O=C(NC(CNC(=O)c1ccccc1-c1ncn[nH]1)C1CC1)c1ccon1
O=C(NCC1CN(C(=O)C2CCCO2)CCCO1)c1c(F)ccc2[nH]cnc12
CP000632666498
-27.63
O=C(NCC1CN(C(=O)C2CCCO2)CCCO1)c1cccc2[nH]cnc12
O=C(NC[C@@H]1CCCN1C(=O)C=Cc1ccco1)c1ccc2c(c1)CCCC2
CP000739315640
-29.6
O=C(NC[C@@H]1CCCN1C(=O)C=Cc1ccco1)c1ccc2c(c1)CCCC2
CC(C)(C)O[C@H]1C[C@@H](C(=O)NC(CNC(=O)[C@H]2CCCC(=O)N2)C2CC2)C1
CP002239224371
-19.48
O=C1CCC[C@H](C(=O)NCC(NC(=O)C2CCC2)C2CC2)N1
CC(CNC(=O)C=Cc1ccsc1)CNC(=O)Cc1ccc2cccnc2c1
CP001032025195
-28.47
O=C(C=Cc1ccsc1)NCCCNC(=O)Cc1ccc2cccnc2c1
CCCN(CCNC(=O)c1ccncc1C)C(=O)C1(Nc2ccccc2)CC1
CP001068241490
-25.12
O=C(NCCNC(=O)C1(Nc2ccccc2)CC1)c1ccncc1
CC1C(=O)Nc2ccccc2CN1C(=O)CCc1cnn(C)n1
CP001530523799
-29.41
O=C1CN(C(=O)CCc2cn[nH]n2)Cc2ccccc2N1
CC1CC(NC(=O)c2c[nH]c(=O)cn2)CN1C(=O)CC1CN(C)C1
CP003374388281
-44.55
O=C(NC1CCN(C(=O)CC2CNC2)C1)c1c[nH]c(=O)cn1
Cc1cc(CC(=O)N2CC3CC2CCC3NC(=O)COc2ccccc2)n(C)n1
CP000151182398
-24.32
O=C(COc1ccccc1)NC1CCC2CC1CN2C(=O)Cc1ccn[nH]1
Cn1cc(S(=O)(=O)NC2CCNCCC2(F)F)c(C2CCC2)n1
CP001556638953
-39.13
O=S(=O)(NC1CCCNCC1)c1c[nH]nc1C1CCC1
Cn1cc(CC(=O)N2CCCC2CNC(=O)C2=CC3CCCCCC23)nn1
CP002076701097
null
O=C(NCC1CCCN1C(=O)Cc1c[nH]nn1)C1=CC2CCCCCC12
CC(CC1CCCC1)C(=O)NC[C@H]1C[C@H](NC(=O)c2n[nH]c(=O)[nH]c2=O)C1
CP001832772773
-13.15
O=C(CCC1CCCC1)NC[C@H]1C[C@H](NC(=O)c2n[nH]c(=O)[nH]c2=O)C1
CC1(C)C=C(C(=O)N2CCC(F)(CNC(=O)c3ccc4cccnc4n3)CC2)C1
CP000017307776
-27.31
O=C(NCC1CCN(C(=O)C2=CCC2)CC1)c1ccc2cccnc2n1
COc1ccnc(-c2cn(Cc3ncoc3CNC(=O)C(O)C3CC3)nn2)c1
CP001113126351
-31.92
O=C(CC1CC1)NCc1ocnc1Cn1cc(-c2ccccn2)nn1
CC1(CC(=O)NCc2ocnc2Cn2cc(-c3cccc(F)n3)nn2)CC1
CP001170487784
-27.64
O=C(CC1CC1)NCc1ocnc1Cn1cc(-c2ccccn2)nn1
C=CCC1(NC(=O)c2cn(C)nn2)CN(C(=O)CCc2cnn(C)c2)C1
CP002595487159
-26.89
O=C(NC1CN(C(=O)CCc2cn[nH]c2)C1)c1c[nH]nn1
CCCc1c(C(=O)NC2(CO)CN(C(=O)CCc3cn[nH]c3)C2)nnn1CC
CP000847223130
-24.41
O=C(NC1CN(C(=O)CCc2cn[nH]c2)C1)c1c[nH]nn1
CCCn1cc(C(=O)NC2(CO)CN(C(=O)CCc3cnn(C)c3C)C2)nn1
CP000845587341
-24.02
O=C(NC1CN(C(=O)CCc2cn[nH]c2)C1)c1c[nH]nn1
C[C@H](NC(=O)c1cc2n(n1)CCCO2)C1CN(c2nnc(C3CC3)o2)C1
CP002222167445
-23.99
O=C(NCC1CN(c2nnc(C3CC3)o2)C1)c1cc2n(n1)CCCO2
CCOC(CC)C(=O)N1CCC[C@@H]1CCNC(=O)c1cn2nc(C)sc2n1
CP001942455362
-26.83
O=C(NCC[C@H]1CCCN1)c1cn2ncsc2n1
O=C1CC[C@@H](C(=O)N2CC(NC(=O)c3ccc(=O)[nH]c3)CC3(CCC3)C2)N1
CP001855632574
-20.08
O=C1CC[C@@H](C(=O)N2CC(NC(=O)c3ccc(=O)[nH]c3)CC3(CCC3)C2)N1
CN1CCCC1CCC(=O)NC1(CNC(=O)C2(C3CC3)CCC2)CCCCC1
CP001186925145
-41.2
O=C(CCC1CCCN1)NC1(CNC(=O)C2(C3CC3)CCC2)CCCCC1
CCc1ccccc1C(=O)N1CCCC[C@H]1CNC(=O)CC1CSC1
CP003099395757
-29.94
O=C(CC1CSC1)NC[C@@H]1CCCCN1C(=O)c1ccccc1
CCc1ccc(C(=O)N2CCCC[C@H]2CN(C)C(=O)CC2CSC2)cc1
CP002803319112
-28.68
O=C(CC1CSC1)NC[C@@H]1CCCCN1C(=O)c1ccccc1
C=Cc1ccc(C(=O)N2CCCC[C@H]2CNC(=O)CC2CSC2)cc1
CP003099417011
-28.09
O=C(CC1CSC1)NC[C@@H]1CCCCN1C(=O)c1ccccc1
CCc1ccc(C(=O)N2CCCC[C@H]2CN(C)C(=O)CC2CSC2)c(F)c1
CP001618350375
-27.82
O=C(CC1CSC1)NC[C@@H]1CCCCN1C(=O)c1ccccc1
Cc1cccc(C(=O)N2CCCC[C@H]2CN(C)C(=O)CC2CSC2)c1
CP003252001188
-25.94
O=C(CC1CSC1)NC[C@@H]1CCCCN1C(=O)c1ccccc1
Cc1ccc(F)c(C(=O)N2CCCC[C@H]2CN(C)C(=O)CC2CSC2)c1
CP002803495018
-25.22
O=C(CC1CSC1)NC[C@@H]1CCCCN1C(=O)c1ccccc1
Cc1cc(C)c(C(=O)NCC2CCN2C(=O)Cn2nnc3ccccc32)c(=O)o1
CP000142327806
-26.44
O=C(NCC1CCN1C(=O)Cn1nnc2ccccc21)c1cccoc1=O
CCC(C(=O)N1C2CCC1CN(C(=O)c1c(C)ncn1C)C2)N1CCCC1=O
CP001096137270
-18.4
O=C1CCCN1CC(=O)N1C2CCC1CN(C(=O)c1cnc[nH]1)C2
Cc1nocc1C(=O)NC(C)C(=O)OCc1ccccc1
CP002282419565
-33.96
O=C(CNC(=O)c1cnoc1)OCc1ccccc1
CC(C)(C)OC(=O)C1CC(NC(=O)C(=O)N2CCC3(CC2)CNC(=O)C3)C1
CP001286980327
-23.36
O=C1CC2(CCN(C(=O)C(=O)NC3CCC3)CC2)CN1
CC(C)CCn1cc(C(=O)NCCOCCCNC(=O)C2=NNC(=O)C2)nn1
CP000774364410
-26.61
O=C1CC(C(=O)NCCCOCCNC(=O)c2c[nH]nn2)=NN1
Cc1cnc(N2CCC(NC(=O)CN3C(=O)C(=O)N(C)C3=O)C2(C)C)nc1C
CP000447855253
-25.07
O=C(CN1C(=O)NC(=O)C1=O)NC1CCN(c2ncccn2)C1
CC(=O)N1CC(C(=O)NCCNC(=O)c2ccnc(-n3cccc3)c2)C1
CP002811314590
-26.56
O=C(NCCNC(=O)C1CNC1)c1ccnc(-n2cccc2)c1
NC(=O)N1CC(O)CC1C(=O)N[C@H]1CC[C@H](NC(=O)CN2CCOCC2)CC1
CP001025204062
-17.85
O=C(CN1CCOCC1)N[C@H]1CC[C@H](NC(=O)C2CCCN2)CC1
CCc1cc(N2CCCC23CCN(C(=O)C2CCCCNC2=O)C3)nc(CC)n1
CP000281949807
-32.33
O=C1NCCCCC1C(=O)N1CCC2(CCCN2c2ccncn2)C1
O=C1NCCCCC1C(=O)N1CCC2(CCCN2c2ccnc(Cl)n2)C1
CP002214856136
-18.1
O=C1NCCCCC1C(=O)N1CCC2(CCCN2c2ccncn2)C1
COC1(C(=O)Nc2sc(C)nc2C)CCS(=O)(=O)C1
CP002854489200
-17.12
O=C(Nc1cncs1)C1CCS(=O)(=O)C1
O=C(N[C@@H]1CCN(Cc2nnc(-c3cccc(F)c3)o2)C1)C1(C(F)F)CCC1
CP000543189005
-26.71
O=C(N[C@@H]1CCN(Cc2nnc(-c3ccccc3)o2)C1)C1CCC1
O=C(NC1(C(F)F)CC2(CCC2)C1)C1CCCc2ccnn21
CP001678980234
-24.03
O=C(NC1CC2(CCC2)C1)C1CCCc2ccnn21
C=CCC1(C(=O)NCCC2(CNC(=O)c3cc(C)c(C)[nH]c3=O)CC2)CC=CC1
CP000031193802
-26.07
O=C(NCC1(CCNC(=O)C2CC=CC2)CC1)c1ccc[nH]c1=O
CC1(OCC(=O)N2CC(NC(=O)c3cnn4ccncc34)C2)CCCC1
CP003003417112
-26.41
O=C(NC1CN(C(=O)COC2CCCC2)C1)c1cnn2ccncc12
COc1cccc(C(O)C(=O)N2CCC[C@H](NC(=O)c3c[nH]c(=O)n3C)C2)c1
CP001139328627
-27.25
O=C(N[C@H]1CCCN(C(=O)Cc2ccccc2)C1)c1c[nH]c(=O)[nH]1
Cn1c(C(=O)N[C@H]2CCCN(C(=O)Cc3ccc(F)c(F)c3)C2)c[nH]c1=O
CP002123340023
-21.76
O=C(N[C@H]1CCCN(C(=O)Cc2ccccc2)C1)c1c[nH]c(=O)[nH]1
Cn1cc(C(=O)N[C@H]2CCCN(C(=O)Cc3ccc(C#N)cc3F)C2)n(C)c1=O
CP000369469732
-19.81
O=C(N[C@H]1CCCN(C(=O)Cc2ccccc2)C1)c1c[nH]c(=O)[nH]1
CCC1(CNC(=O)C(=O)N2CCN(CC3CCCO3)CC2)CCCCC1
CP001512683809
-48.38
O=C(NCC1CCCCC1)C(=O)N1CCN(CC2CCCO2)CC1
CCn1ccc(C(=O)N2CC([C@H](C)NC(=O)c3cn4c(n3)COCC4)C2)cc1=O
CP000084307161
-25.02
O=C(NCC1CN(C(=O)c2cc[nH]c(=O)c2)C1)c1cn2c(n1)COCC2
CCCN(CCNC(=O)CCCc1ccccn1)C(=O)Cc1nccc(OC)n1
CP000347158837
-21.11
O=C(CCCc1ccccn1)NCCNC(=O)Cc1ncccn1
CC(C)C(=O)NC1CN(C(=O)Cc2cn(C)nn2)CC2(CC2)C1
CP003512302691
-21.75
O=C(Cc1c[nH]nn1)N1CCCC2(CC2)C1
CCC(F)C(=O)NC1C=CCN(c2nc3c(c(C#N)c2C#N)CCCCCC3)C1
CP000249546751
null
C1=CCN(c2ccc3c(n2)CCCCCC3)CC1
Cn1ccc(C(=O)NC2CCC3CN(C(=O)C4(C)COC4)CCC3C2)c1
CP002600406803
-24.98
O=C(NC1CCC2CN(C(=O)C3COC3)CCC2C1)c1cc[nH]c1