clean_smiles
stringlengths
18
103
id
stringlengths
14
14
value
float64
-72.94
187
scaffold
stringlengths
0
100
COC1CCCC1C(=O)NCC1CCN(C(=O)C2=CCC2)C1
CP003487501281
-21.72
O=C(NCC1CCN(C(=O)C2=CCC2)C1)C1CCCC1
CNC(=O)NC1(C(=O)NCC2CC(C)N(C(=O)C3=CC(C)(C)C3)C2)CCCC1
CP001079767654
-21.47
O=C(NCC1CCN(C(=O)C2=CCC2)C1)C1CCCC1
CC1CC(CNC(=O)C2(N(C)C)CCCC2)CN1C(=O)C1=CCC1
CP003418401017
-19.84
O=C(NCC1CCN(C(=O)C2=CCC2)C1)C1CCCC1
CC(=O)CC1(C(=O)NCC2CC(C)N(C(=O)C3=CCC3)C2)CCCC1
CP003061236960
-18.71
O=C(NCC1CCN(C(=O)C2=CCC2)C1)C1CCCC1
Cn1cnnc1C(=O)N1CCC(OCCCNC(=O)CN2CCCC2=O)CC1
CP000898477126
-22.79
O=C(CN1CCCC1=O)NCCCOC1CCN(C(=O)c2nnc[nH]2)CC1
O=S(=O)(Nc1nnc(Cc2ccc(F)cc2)s1)c1ccc(Cl)s1
CP001548164191
-16.3
O=S(=O)(Nc1nnc(Cc2ccccc2)s1)c1cccs1
Cc1nccc(CCC(=O)NCC(C)NC(=O)c2cnn3c2CCCN3)n1
CP002308309816
-30.92
O=C(CCc1ccncn1)NCCNC(=O)c1cnn2c1CCCN2
CC(OCC1CC1)C(=O)N1CCCC[C@@H]1CNC(=O)[C@H]1CCCN1C
CP003086843092
-39.51
O=C(NC[C@H]1CCCCN1C(=O)COCC1CC1)[C@H]1CCCN1
CC1(C(=O)N2C3CCCC2CN(C(=O)COc2ccon2)C3)CCC(=O)C1
CP002208852276
-19.64
O=C1CCC(C(=O)N2C3CCCC2CN(C(=O)COc2ccon2)C3)C1
CCc1c(C(=O)N2CCCCC(NC(=O)C=Cc3ccccn3)C2)cnn1CC
CP000159661400
-24.99
O=C(C=Cc1ccccn1)NC1CCCCN(C(=O)c2cn[nH]c2)C1
COc1cnc(C(=O)N2CCC(C)C2CNC(=O)c2cccn3cnnc23)nc1
CP000170152757
-26.14
O=C(NCC1CCCN1C(=O)c1ncccn1)c1cccn2cnnc12
CC1CC(NC(=O)C23CCOC2CCOC3)CN1C(=O)C1CCC=CO1
CP002532168602
-19.84
O=C(C1CCC=CO1)N1CCC(NC(=O)C23CCOC2CCOC3)C1
Cc1cccc(OCCC(=O)N2CCN(C(=O)[C@@H]3CNC(=O)O3)CC2)c1C
CP002325192709
-22.41
O=C1NC[C@@H](C(=O)N2CCN(C(=O)CCOc3ccccc3)CC2)O1
O=C(NCCCCCCNC(=O)[C@@H]1CCOC1)c1cccc(N2CC=CC2)c1
CP001191726420
-26.47
O=C(NCCCCCCNC(=O)[C@@H]1CCOC1)c1cccc(N2CC=CC2)c1
Cc1ncc2ccccc2c1C(=O)NCCCNc1nc2c(cnn2C)c(=O)[nH]1
CP000294607157
-29.31
O=C(NCCCNc1nc2[nH]ncc2c(=O)[nH]1)c1cncc2ccccc12
CC1(C)C(O)CC1CC(=O)N[C@H]1[C@@H]2CN(C(=O)c3c[nH]nc3C3CC3)C[C@@H]21
CP002303581120
-27.34
O=C(CC1CCC1)N[C@H]1[C@@H]2CN(C(=O)c3c[nH]nc3C3CC3)C[C@@H]21
COC(C(=O)N[C@H]1[C@@H]2CN(C(=O)c3c[nH]nc3C3CC3)C[C@@H]21)C1CC(F)(F)C1
CP001232923008
-21.35
O=C(CC1CCC1)N[C@H]1[C@@H]2CN(C(=O)c3c[nH]nc3C3CC3)C[C@@H]21
Cn1nccc1CC(=O)N1CCC[C@H](CNC(=O)[C@@H]2Cc3cncn3C(=O)N2)C1
CP000184716650
-20.42
O=C(NC[C@H]1CCCN(C(=O)Cc2ccn[nH]2)C1)[C@@H]1Cc2cncn2C(=O)N1
CC1(C)CC(C(=O)N(CCNC(=O)c2c[nH]c(C3CC3)n2)Cc2ccccc2)C1
CP000264770549
-27.24
O=C(NCCN(Cc1ccccc1)C(=O)C1CCC1)c1c[nH]c(C2CC2)n1
O=C(NC1CCCN(C(=O)CCc2cccs2)CC1)C1CCCC(F)C1
CP001266798268
-31.14
O=C(NC1CCCN(C(=O)CCc2cccs2)CC1)C1CCCCC1
Cc1cc(NCC2CC(NC(=O)c3c[nH]c(C)n3)C2)nc(CC2CC2)n1
CP001919538051
-48.95
O=C(NC1CC(CNc2ccnc(CC3CC3)n2)C1)c1c[nH]cn1
C[C@@H]1CN(C(=O)C2=CCOCC2)CCN1C(=O)C1CC2(CC(O)C2)C1
CP003043687127
-17.59
O=C(C1=CCOCC1)N1CCN(C(=O)C2CC3(CCC3)C2)CC1
CN(CC1CN(C(=O)c2cc(N)cc(N)c2)C1)C(=O)C1CCC2CCCCN21
CP000714594212
-48.49
O=C(NCC1CN(C(=O)c2ccccc2)C1)C1CCC2CCCCN21
CN(CC1CN(C(=O)c2ccccc2Cl)C1)C(=O)C1CCC2CCCCN21
CP001781901724
-48.23
O=C(NCC1CN(C(=O)c2ccccc2)C1)C1CCC2CCCCN21
CCc1ccc(C(=O)N2CC(O)(CNC(=O)C3CCC4CCCCN43)C2)cc1
CP000708301675
-47.59
O=C(NCC1CN(C(=O)c2ccccc2)C1)C1CCC2CCCCN21
CC(CC1CCCC1)C(=O)N1CC(C)C(CNC(=O)Cn2ncnn2)C1
CP002682943181
-19.01
O=C(Cn1ncnn1)NCC1CCN(C(=O)CCC2CCCC2)C1
Cc1nc(O)ccc1C(=O)NCCC1(O)CN(C(=O)c2ccncc2)C1
CP002786969045
-26.75
O=C(NCCC1CN(C(=O)c2ccncc2)C1)c1cccnc1
Cc1cncc(C(=O)NCCC2(O)CN(C(=O)c3ccnc(CO)c3)C2)c1
CP002125886494
-26.14
O=C(NCCC1CN(C(=O)c2ccncc2)C1)c1cccnc1
Cc1ccc(C(=O)NC(C)CC2CN(C(=O)c3ccncc3N)C2)cn1
CP002588810141
-24.23
O=C(NCCC1CN(C(=O)c2ccncc2)C1)c1cccnc1
CC(CC1CN(C(=O)c2ccncc2F)C1)NC(=O)c1cccnc1C(F)F
CP000710557492
-24.19
O=C(NCCC1CN(C(=O)c2ccncc2)C1)c1cccnc1
COc1ncccc1C(=O)NC(C)CC1CN(C(=O)c2ccncc2N)C1
CP001777743176
-20.42
O=C(NCCC1CN(C(=O)c2ccncc2)C1)c1cccnc1
CCCn1cc(C(=O)N2CC[C@H](CNC(=O)c3cc(N(C)C)ccn3)C2)cn1
CP001264818049
-28.13
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
CCn1ncc(C(=O)N2CC[C@H](CNC(=O)c3ccccn3)C2)c1C
CP003049094072
-27.06
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
Cc1cnc(C(=O)NC[C@H]2CCN(C(=O)c3cn[nH]c3C)C2)c(C)c1
CP003049922329
-26.71
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
CCn1cc(C(=O)N2CC[C@H](CNC(=O)c3cccc(F)n3)C2)cn1
CP003049980734
-25.16
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
CCc1nn(C)cc1C(=O)N1CC[C@H](CNC(=O)c2ccc(C)c(F)n2)C1
CP002446626886
-24.72
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
Cc1cc(C)nc(C(=O)NC[C@H]2CCN(C(=O)c3cnn(CCO)c3)C2)c1
CP002445066410
-24.27
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
Cc1ccc(C(=O)NC[C@H]2CCN(C(=O)c3cn(C(C)C)nc3C)C2)nc1
CP002446067372
-24.17
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
Cn1cc(C(=O)N2CC[C@H](CNC(=O)c3ccc(F)cn3)C2)c(C(F)(F)F)n1
CP001264506489
-23.99
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
CCCCn1cc(C(=O)N2CC[C@H](CNC(=O)c3ncccc3F)C2)c(C)n1
CP001102072673
-23.74
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
COc1cc(C)cnc1C(=O)NC[C@H]1CCN(C(=O)c2c(C)nn(C)c2C)C1
CP001102856735
-23.34
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
Cc1nn(C)c(C)c1C(=O)N1CC[C@H](CNC(=O)c2cc(C(N)=O)ccn2)C1
CP001101895713
-22.34
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
Cc1nn(CCO)cc1C(=O)N1CC[C@H](CNC(=O)c2ccc(CO)cn2)C1
CP001103774476
-22.01
O=C(NC[C@H]1CCN(C(=O)c2cn[nH]c2)C1)c1ccccn1
Cc1ncc(CN2CCN(CCCNC(=O)c3scnc3C)CC2)o1
CP002409482941
-35.9
O=C(NCCCN1CCN(Cc2cnco2)CC1)c1cncs1
Cc1ccncc1C(=O)N1CC2CC(NC(=O)c3cnc(C(N)=O)cn3)C2C1
CP000994107313
-24.81
O=C(NC1CC2CN(C(=O)c3cccnc3)CC21)c1cnccn1
Nc1ncc(C(=O)N2CC3CC(NC(=O)c4nccnc4N)C3C2)cc1Cl
CP002036358352
-23.64
O=C(NC1CC2CN(C(=O)c3cccnc3)CC21)c1cnccn1
COCc1ncc(NC(=O)N2CCC(Oc3ccccn3)C2)cn1
CP001329325398
-30.27
O=C(Nc1cncnc1)N1CCC(Oc2ccccn2)C1
CN1CCc2ccc(NC(=O)C(=O)NC(CO)c3ccnn3C)cc2C1
CP001507669188
-42.97
O=C(NCc1ccn[nH]1)C(=O)Nc1ccc2c(c1)CNCC2
CC1(NC(=O)c2ccc(-n3cncn3)nc2)CN(C(=O)CCN2CCOCC2)C1
CP000069741690
-49.31
O=C(NC1CN(C(=O)CCN2CCOCC2)C1)c1ccc(-n2cncn2)nc1
Cn1cc(Cl)cc1C(=O)NC1CN(C(=O)C2CC23CCOCC3)CC1(C)C
CP001628419139
-26.44
O=C(NC1CCN(C(=O)C2CC23CCOCC3)C1)c1ccc[nH]1
C=CC(O)C(=O)NC1CC(NC(=O)c2cnn(C)c2-n2cccc2)C12CCC2
CP000645354748
-25.5
O=C(NC1CCC12CCC2)c1cn[nH]c1-n1cccc1
COC1(CCNc2nnc(C)o2)CN(C(=O)[C@H]2CCCO2)C1
CP003474348133
-15.98
O=C([C@H]1CCCO1)N1CC(CCNc2nnco2)C1
Cc1cc(C(=O)N2CC(CNC(=O)C3(Cc4ccc(F)cc4)CC3)C2)c(=O)[nH]n1
CP000382350449
-22.53
O=C(c1ccn[nH]c1=O)N1CC(CNC(=O)C2(Cc3ccccc3)CC2)C1
COc1ccc2[nH]nc(C(=O)N3CCN(C(=O)CC4CC4C)CC34CCC4)c2c1
CP000105057113
-29.13
O=C(CC1CC1)N1CCN(C(=O)c2n[nH]c3ccccc23)C2(CCC2)C1
COc1ccc2[nH]nc(C(=O)N3CCN(C(=O)CC4(C)CC4)CC34CCC4)c2c1
CP000105057108
-23
O=C(CC1CC1)N1CCN(C(=O)c2n[nH]c3ccccc23)C2(CCC2)C1
Cc1cc(N2CC3C4CCC(C3C2)N(C(=O)C2C=CCC2)C4)nc(C(C)C)n1
CP000437474642
null
O=C(C1C=CCC1)N1CC2CCC1C1CN(c3ccncn3)CC21
CCC(CNC(=O)c1ccc2cncn2c1)NC(=O)C1CCc2nnc(C)n2C1
CP000160853938
-29.07
O=C(NCCNC(=O)C1CCc2nncn2C1)c1ccc2cncn2c1
Cc1cc(C(=O)N(CCNC(=O)c2cncc3c2CCCC3)C2CC2)cn1C
CP001088923012
-27.81
O=C(NCCN(C(=O)c1cc[nH]c1)C1CC1)c1cncc2c1CCCC2
CC(CCN1CCOC1=O)Nc1cnc(F)cn1
CP000622109954
-24.93
O=C1OCCN1CCCNc1cnccn1
Cc1ccccc1OCC(=O)NC1CCN(C(=O)CCc2ccccn2)CC1O
CP000041242833
-29
O=C(COc1ccccc1)NC1CCN(C(=O)CCc2ccccn2)CC1
COC(C)CC(=O)N1[C@@H]2CC[C@H]1C[C@@H](CNC(=O)C1CC=Cc3ccccc31)C2
CP000073757114
null
O=C(NC[C@H]1C[C@H]2CC[C@@H](C1)N2)C1CC=Cc2ccccc21
CC1(C(=O)N2CCOC3(CN(C(=O)C=Cc4ccccn4)C3)C2)CCCO1
CP002016604968
-23.76
O=C(C=Cc1ccccn1)N1CC2(C1)CN(C(=O)C1CCCO1)CCO2
CC1CCN(C(=O)CN2CC=C(CCNC(=O)C3CCC(F)CC3)CC2)CC1
CP000493495500
-22.53
O=C(NCCC1=CCN(CC(=O)N2CCCCC2)CC1)C1CCCCC1
O=C(C(F)CC1CC1)N1CCC2CCC(C1)N2C(=O)CC1CC(F)C1
CP003289473297
-19.33
O=C(CCC1CC1)N1CCC2CCC(C1)N2C(=O)CC1CCC1
CN(CC(O)CN(C)c1ccncc1C#N)C(=O)Cc1n[nH]c2c1CCCC2
CP000419529955
-25.71
O=C(Cc1n[nH]c2c1CCCC2)NCCCNc1ccncc1
CC(C)[C@@H](CCNC(=O)Cc1n[nH]c2c1CCCC2)Nc1ccncc1C#N
CP000417423097
-24.3
O=C(Cc1n[nH]c2c1CCCC2)NCCCNc1ccncc1
CC(=CC(=O)N1CC(CNC(=O)CCOCC2CCCO2)C1)c1ccco1
CP002450331647
-28.19
O=C(CCOCC1CCCO1)NCC1CN(C(=O)C=Cc2ccco2)C1
Cn1cc(CCC(=O)NC(CNC(=O)[C@H]2CC2(F)F)C2CCCC2)cn1
CP002717925562
-25.06
O=C(CCc1cn[nH]c1)NC(CNC(=O)C1CC1)C1CCCC1
Cc1cnc(C(=O)N2CC(C)C(NC(=O)C(C)(C)c3cncnc3)C2)cn1
CP001874732511
-28.44
O=C(Cc1cncnc1)NC1CCN(C(=O)c2cnccn2)C1
Cc1nc(C)c(C(=O)N2CC(C)C(NC(=O)Cc3cncnc3)C2)nc1C
CP001876354393
-24.86
O=C(Cc1cncnc1)NC1CCN(C(=O)c2cnccn2)C1
CC(CC1CCC1)C(=O)NCC1C2CN(C(=O)Cc3ccnc(F)c3)CC12
CP001995176458
-21.03
O=C(CCC1CCC1)NCC1C2CN(C(=O)Cc3ccncc3)CC12
CC(CN(C)C(=O)c1ccc2ccncc2n1)NC(=O)c1cc(O)cc(Cl)n1
CP001208492933
-33.99
O=C(NCCNC(=O)c1ccc2ccncc2n1)c1ccccn1
CCCN(CCNC(=O)c1ccc2ccnc(O)c2n1)C(=O)c1cccc(N)n1
CP000347873780
-32.25
O=C(NCCNC(=O)c1ccc2ccncc2n1)c1ccccn1
CC(CNC(=O)c1ccc2ccncc2n1)NC(=O)c1nc(Cl)ccc1N
CP002308285807
-28.89
O=C(NCCNC(=O)c1ccc2ccncc2n1)c1ccccn1
C[C@H](CNC(=O)c1ccc2ccnc(O)c2n1)NC(=O)c1cc(N)ccn1
CP002157996701
-24.74
O=C(NCCNC(=O)c1ccc2ccncc2n1)c1ccccn1
CC1CCCN(C(=O)C(=O)NCC(C)N(C)C(=O)c2ccc3ncccc3c2)C1
CP000232355269
-29.33
O=C(NCCNC(=O)c1ccc2ncccc2c1)C(=O)N1CCCCC1
CC1(CC(=O)N[C@H]2C[C@@H](NC(=O)C3(c4ccccc4)CC3(C)C)C2)CC1
CP002968794355
-23.13
O=C(CC1CC1)N[C@H]1C[C@@H](NC(=O)C2(c3ccccc3)CC2)C1
Cc1c(F)cccc1C1(C(=O)N[C@H]2C[C@@H](NC(=O)CC3(C#N)CC3)C2)CC1
CP002250417253
-20.41
O=C(CC1CC1)N[C@H]1C[C@@H](NC(=O)C2(c3ccccc3)CC2)C1
CC(C)(C(=O)N[C@H]1C[C@@H](NC(=O)C2(c3ccccc3)CC2(C)C)C1)C1CC1
CP002248713711
-18.78
O=C(CC1CC1)N[C@H]1C[C@@H](NC(=O)C2(c3ccccc3)CC2)C1
Cn1ccnc1SCc1ccc(C(=O)N2CC[C@@]3(CO)CCC[C@@H]23)o1
CP001224706731
-29.38
O=C(c1ccc(CSc2ncc[nH]2)o1)N1CCC2CCC[C@H]21
CC(CCCNC(=O)[C@H]1C[C@@H]1C)NC(=O)C1CN(C)CC1C(F)(F)F
CP003064456858
-44.54
O=C(NCCCCNC(=O)C1CCNC1)C1CC1
CC(CCCNC(=O)C1CN(C)CC1C(F)(F)F)NC(=O)[C@H]1C[C@@H]1C
CP003063942747
-42.35
O=C(NCCCCNC(=O)C1CCNC1)C1CC1
Cc1ncnc(C)c1C(=O)N1CCC([C@H](C)NC(=O)COC2CCOC2)CC1
CP000581437049
-20.99
O=C(COC1CCOC1)NCC1CCN(C(=O)c2cncnc2)CC1
COCCC(=O)N1CC2C(CNC(=O)c3noc4ccc(Cl)cc34)C2C1
CP002677198497
-24.72
O=C(NCC1C2CNCC21)c1noc2ccccc12
CCc1ncoc1C(=O)NC1CCC(NC(=O)C2C3CCC(C3)C2(C)C)CC1
CP001235576714
null
O=C(NC1CCC(NC(=O)C2CC3CCC2C3)CC1)c1cnco1
Cc1cc(C(=O)NCC2(NC(=O)Cc3cccs3)CCCCC2)sn1
CP003256471726
-24.85
O=C(Cc1cccs1)NC1(CNC(=O)c2ccns2)CCCCC1
Cc1nc(O)c(C)c(N[C@H]2CCN(C(=O)c3n[nH]c4ccccc4c3=O)C2)n1
CP000487009050
-14.53
O=C(c1n[nH]c2ccccc2c1=O)N1CC[C@H](Nc2ccncn2)C1
Cc1ccc(O)c(C(=O)N2CCCC(CNC(=O)C3CCc4cn[nH]c4C3)C2)c1
CP000342580104
-27.03
O=C(NCC1CCCN(C(=O)c2ccccc2)C1)C1CCc2cn[nH]c2C1
CC(CC1CCC1)C(=O)N(C)C(C)CNc1cc(OC2CCOCC2)ncn1
CP000462336950
-26.06
O=C(CCC1CCC1)NCCNc1cc(OC2CCOCC2)ncn1
CC1CCN(C(=O)c2cc3c(s2)CCOC3)CCN1C(=O)CC1CSC1
CP002509189433
-23.8
O=C(CC1CSC1)N1CCCN(C(=O)c2cc3c(s2)CCOC3)CC1
Cc1ccccc1C(=O)N(CCNC(=O)c1nc(C2CC2)ncc1Cl)C1CC1
CP001088524290
-27.68
O=C(NCCN(C(=O)c1ccccc1)C1CC1)c1ccnc(C2CC2)n1
COc1ccc(C(=O)N(CCNC(=O)c2ccnc(C3CC3)n2)C2CC2)cc1F
CP000348312364
-27.12
O=C(NCCN(C(=O)c1ccccc1)C1CC1)c1ccnc(C2CC2)n1
CCc1cc(N)ccc1C(=O)N(CCNC(=O)c1ccnc(C2CC2)n1)C1CC1
CP000348312703
-25.45
O=C(NCCN(C(=O)c1ccccc1)C1CC1)c1ccnc(C2CC2)n1
O=C1CC(C(=O)N2CCC(CCNC(=O)c3cc4ccccc4c(=O)o3)C2)=NN1
CP000224126063
-32.83
O=C1CC(C(=O)N2CCC(CCNC(=O)c3cc4ccccc4c(=O)o3)C2)=NN1
CCOC(CC)C(=O)N1CCC(NC(=O)C2=CCCO2)C12CCC2
CP003341584246
-21.63
O=C(NC1CCNC12CCC2)C1=CCCO1
COc1ccc(OC)c(C2CC2C(=O)N2CCNCC2c2ccncc2)c1
CP001291332893
-23.1
O=C(C1CC1c1ccccc1)N1CCNCC1c1ccncc1
Cc1ncnc(C)c1C(=O)NC(C)CNC(=O)C1CC2(CSC2)C1
CP003456712862
-24.19
O=C(NCCNC(=O)C1CC2(CSC2)C1)c1cncnc1
CN(CCN(C)C(=O)C1CC2(CSC2)C1)C(=O)c1cnc(N)nc1
CP003439234921
-24.15
O=C(NCCNC(=O)C1CC2(CSC2)C1)c1cncnc1
CCc1ncncc1C(=O)NC[C@H](C)NC(=O)C1CC2(CSC2)C1
CP003394790296
-22.3
O=C(NCCNC(=O)C1CC2(CSC2)C1)c1cncnc1
C=C1CC1C(=O)N1CCC2C(CCCN2C(=O)C2(C(=O)OCC)CCO2)C1
CP001757068244
-25.14
C=C1CC1C(=O)N1CCC2C(CCCN2C(=O)C2CCO2)C1