ID
stringlengths
13
17
question
stringlengths
88
1.13k
answer
stringlengths
6
156
reference_sequence
stringlengths
4.1k
4.1k
variant_sequence
stringlengths
4.1k
4.1k
Task1_train_24300
This gene mutation involves KRT14 (keratin 14) on Chromosome 17. Is it associated with any clinical condition, or is it benign?
Pathogenic; Epidermolysis bullosa simplex
TCTGTCTCATACCTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTG
TCTGTCTCATACCTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTCGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTG
Task1_train_24301
Here is a variant affecting KRT14 (keratin 14) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; not provided
TCTGTCTCATACCTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTG
TCTGTCTCATACCTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTGGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTG
Task1_train_24302
This alteration in KRT14 (keratin 14) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; not provided
CCTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCA
CCTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGAGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCA
Task1_train_24303
Consider a variant on Chromosome 17 in gene KRT14 (keratin 14). Determine its clinical classification and disease relevance.
Pathogenic; Dermatopathia pigmentosa reticularis
CCTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCA
CCTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGTGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCA
Task1_train_24304
Given this variant in gene KRT14 (keratin 14) on Chromosome 17, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Epidermolysis bullosa simplex 1A, generalized severe
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
Task1_train_24305
A mutation found in KRT14 (keratin 14) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Epidermolysis bullosa simplex, Koebner type
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
Task1_train_24306
This mutation is located in gene KRT14 (keratin 14) on Chromosome 17. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; Inborn genetic diseases
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
Task1_train_24307
Gene KRT14 (keratin 14) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Epidermolysis bullosa simplex
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
Task1_train_24308
Gene KRT14 (keratin 14) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Epidermolysis bullosa simplex, Koebner type
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
Task1_train_24309
Here is a variant affecting KRT14 (keratin 14) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Epidermolysis bullosa simplex 1A, generalized severe
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
CTGGAATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAA
Task1_train_24310
A genetic alteration is present in KRT14 (keratin 14) on Chromosome 17. Is this variant benign or disease-causing, and if the latter, which condition is involved?
Pathogenic; not provided
ATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAAATCTG
ATGACCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCACTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAAATCTG
Task1_train_24311
A variant was discovered in gene KRT14 (keratin 14), Chromosome 17. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; not provided
CCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAAATCTGCCAG
CCCCAGAGAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAAGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAAATCTGCCAG
Task1_train_24312
Here is a mutation in KRT14 (keratin 14) on Chromosome 17. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; not provided
GAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAAATCTGCCAGCAAAGGA
GAAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGTATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAAATCTGCCAGCAAAGGA
Task1_train_24313
Consider this mutation in KRT14 (keratin 14) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; not provided
AAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAAATCTGCCAGCAAAGGAC
AAAAGGTATGAGACACCCATCCTGATCACAGCGAGGGCTTTGTTCTCTTCTCCCTGCAGCTTCTCCCAGAGCTGGTGCCTTGTGGGTGGTTTAAGGAGCCAATCTTGAAAATGGCGTGGTTGAACACAGTGCCCATTGATTGCTCAGATATGAACATTCCTGCGGGCTGGGGATAAGGCAGTTCATCTTGCTGCAGAAATCAGGAGGGGGTTGCACTTCTAGCTTCAGCCAACAAATAATGCAGAAGTCCTCCAACTATGATTCCTTCCTATACTTCAAGGGCAGCTGGGGAAGTGGAAAGTGCCTCTCCCTAAAGCAGCGGTTCTGAAACCTGGCTGTGGACCAGAATCACCCAGGTAACCTGCTATAAATAGCTGAATCAAAACTCCAAGGGTGGGGCCCAAGAGTCTTATTCTTTTATAAGCACCCCAGGGAGTTTTCATGCACCTATCCTGGTACTGGCTAGTTCTATTTGGGAAACACTGCTCCAAAAATGCCCTACTCTGGGGACACTGGATGTTCTGGCCCACCATTTCAAACTCACTTGGTGCGGAAGTCATCCGCGGCCAGACGGGCATTGTCAATCTGCAGAAGGACATTGGCATTGTCCACTGTGGCTGTGAGAATCTGCAGGATGGAAAAGGCACAGGTAATTTGTCAAATGGACTTCACAAGCTGGACTTCACTGTAGCCTACATTAAGCTCTTGCTTCATGTTCTTGCCTGAATCCCCCTTTTCCCCCACAAAACTTGACCATAGCAGCCCAAAGGAAAACAGATGCCCCAGGCCTGTCCTAAGACTTTGCTAACTCATGGTCAACAGAGGGGGTAGATGCAGCCCCGGGCTTAGAATCGAAAGCCCAGGAGTTCTGGTCCCAATTCTGCCAGTGTCTTGCTGCAAAACCTAATGGGTCTTGGGGCTTCAAGTTCCCCACCTCCAGGTGAGGAGAATAATCTGAGGCTCCCTAGCCCTCCTTCCTGAGCTGACCTCTCTTCTGTCTGCATCAGCCAGCCCTGCCAGTCCTCTGCAGATATGCACATTCCTTTTCAAGCTCACAGGCCATGGGACTTCAAGTGGAACTTTCTCAAGAGATAAAACCCAACTAACACAGGGGATTAGAAAAGAGGACTCAGGGGAAGAATAAGAAGATATATTGGCCCCTGAGTCTGGTTGGATTTCCCCACCTCATCATTGAATTTCCCTAATCCATGCAAGTCATTAGAGCCCAACAGACTCCAGCAGGGAGGGCTCCCAAGTAATGTGGGAGCAGGGAGGAGGGGGCTAGAGTCAGGGCACAAGCCTGCCAGGCTCTCTCTGTGCAGGGCACATCAAGGGACCACACTAATTGTCTCTGCAGGCTCTCCATGCCCGCCTGGCTGTGGGGAGGGACCAGCCTGTACCAAGGCTTATGGGCGGCGGCAGCCACAGCCCAGACTAGTGAGCTAATGAGTGGTTTGGATGTCTTGCCTGGTCCCGTTAGAGCCTCACTCCTCCCCTGTGCTGGAGAACAAGTAGCTGCCTCCTGTGCTGGAAGGTAGGGCACAAGGGCCCCAGCCTTGGCTCTGCCATTAATTTGCTATGTGACCTGCAGCTGGTCACAGCACCTCTCGAAGCTTCAACTGCTTCCTCTAAAAAATGTAAGGATAGGAATCACTGATCTCACATGGTCTGAGGATTTGAGATCAGAAGGGGATGAGGAGGCTGGGGAAGGGAAAGCATCTTCTCACTGATCAGTCTTAGGGCATCCAAGACCTCGAAAGAAGGGATCTGGGGTGGACTCTGTCCTATAGAGAAATCTTAAGGTCTCAGGGGCCTGGGGCATGAATTGTTCCCAGAAGGAGCTAGCTGGAATGGTGCCTTCTGCTGCCCATTCACCCACCTTGTTCCTCAGGTCCTCAATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCAGCAGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCGTGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAGCCACCACCAAAGCCACCACCCAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCAAAGCCACTACCAAAGCTGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGGGAGGATGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCGCGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCCCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCAGAGGAGGGAGGTGAGCGAGCGAGCAGTTGGCTGAGTGAAGAGAAGGTGCTCGGGTAAATTGGAAAGGGATGCGAGTGCTTTATACTCGTGGGTAGGGGGCGGGTCTGGCACTTTCCATTCCCCTTGGCTTTCATCACCCACAGGCTAGCGCCAACTCCCAGCCAGGTCCCTCCTCTCATCCGCCTCATCATGTCTGTCATATTTTACTGGAAACTCATTGTTTGGAGTGTTTTGGGCTTTCTTGTCCCGCCAGGCGTGATTCACAGGGGGAGGTGTGGGCCTGCAGGCTACACTTTCCCATCGGACCCTGGGAGTCCCAGCCCTCAGGAACCCGCGCACTGGGCTTAGCCAGGGTGACAGAGAGCAGGGCCTCTGCACCTTAAACCTAGTTACCTGCTAGCTCTCCATGAACTGAATGGGCCTTTAACATCCACGTAGAGGAAGCCTGCTGCTGCAGGGGATGGATACCCGGCTGGAAAGCACCGGCATGGCAAGGTCACCTTGGGCACAGACAGGCCTCCCTCACCATGACCCTCTATTAGAGACAAGGAGGTCTGGGGGGCCCTCCCAGGCCTGACCTCCCATGCTGTGCTGAGAAGTCTGTCCCATCCCTGAAATACACCCAGCTAGTCAGGTGTATCGTGGTTCCCACCCCAACATCCCCATCAAAGAGAAATCCAGGCAGCTCTCCCCAGCCCTGAGCACAGACCCTAATCTCCTCCCTATGGTGAGGATCTCACATCCACCACACCATAGGGCAGGTGGCCTCATGGAGGCCAGGAAACAGCCTGGAGTCAGGTGGGTCCTGGCTCTGCCATTTACGCCTCTGTGACCCAGGGCTTGGCACTTCTCTGAGCCTCAGTGTTCTCATCTGCAAAGTGGGAGTCATACCATCTATTCTGCTTAGTGCAGTCAGCTCTGAGAATCCAATGCGACAATGTATGTGAAAGGGTTTTGTAAACCGAGTATGGCAAGAAGCCTCGTTGGCATTGTTATAGCCCAGGCTTAGCCCCAAAGTGGCTGGAGCTGCATCCAGGAACAGGCCTAGGGGGGCCTTTTATTCTTCCAGCCCCAGATATCTTCTCAGACCCCCAGAACATCCCTAGTGTGGGCAGCTCAGGCGCCCTCGTTTGAGCCCCTTGTGGAACTGGCCCAGGAGATGTTCTGGGGAGGAGTAGAGGCTGGAGTGGAGCTGGGCTGTGCCAAGGGCAAGGCTGAGGTGGACACGAGGGTCCCTGACTCCTGAAGCCCCAAGGGTCAGGGGACATTTCTAGGAGTCCACTTGGTCCTGCTTTGGAGGTGTGTATATCAAAACTTCAGCAATCTCCCAGACAACCTCCCAAAGCAAACCCTTCCGGCCCCCACCCCACCCTCCCATCAGCCCCTAGGCTCCACAGACCCCGGCAGGCATGTTGAGAGGAATGTGATCGTGTCTGGGGCTGCCTGACGCATCCTATCTCCTCAGACAGGCCCCAACAGCCCCTGCTGGAGGCTCCAATGCTCTTCCTGGGATCAACTGCTCCTAGAAGAGAAGCAGGACCCTCTGTCACCCCCAACCCCACCTTGACTGTCACCAAAGAAGAAGCCAGAGAAGGGAGCCCCCCACTACTGTGGCCTAGGAGCTTGGAAGACAATGCTGAGACAGACATCTGAGCTGTGGGCTCCCCAAATCTGCCAGCAAAGGAC
Task1_train_24314
A mutation in KRT16 (keratin 16), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; not provided
AGAAAAAGCAGGGCAGTCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCT
AGAAAAAGCAGGGCAGTCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCGGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCT
Task1_train_24315
Consider a variant on Chromosome 17 in gene KRT16 (keratin 16). Determine its clinical classification and disease relevance.
Pathogenic; not provided
GCAGTCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCC
GCAGTCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCGGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCC
Task1_train_24316
This variant affects the gene KRT16 (keratin 16) found on Chromosome 17. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; Pachyonychia congenita 1
GCAGTCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCC
GCAGTCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCTGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCC
Task1_train_24317
Gene KRT16 (keratin 16) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Pachyonychia congenita 1
GTCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCG
GTCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGGGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCG
Task1_train_24318
A mutation on Chromosome 17 affecting KRT16 (keratin 16) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; Pachyonychia congenita 1
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
Task1_train_24319
A variant found in Chromosome 17 affects KRT16 (keratin 16). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Palmoplantar keratoderma, nonepidermolytic, focal 1
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
Task1_train_24320
The following genetic variant occurs in KRT16 (keratin 16) on Chromosome 17. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Pachyonychia congenita 1
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
Task1_train_24321
Chromosome 17 houses a mutation in gene KRT16 (keratin 16). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Palmoplantar keratoderma, nonepidermolytic, focal 1
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
Task1_train_24322
Gene KRT16 (keratin 16) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; KRT16-related disorder
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
TCAGTTGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGG
Task1_train_24323
A variant was discovered on Chromosome 17, affecting KRT16 (keratin 16). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Pachyonychia congenita 1
TGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTG
TGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCACTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTG
Task1_train_24324
Here is a variant affecting KRT16 (keratin 16) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; Palmoplantar keratoderma, nonepidermolytic, focal 1
TGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTG
TGTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCACTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTG
Task1_train_24325
A mutation on Chromosome 17 affecting KRT16 (keratin 16) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; not provided
GTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTGG
GTGCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATCGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTGG
Task1_train_24326
A change on Chromosome 17 affects gene KRT16 (keratin 16). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Pachyonychia congenita 1
GCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTGGCC
GCTGAGAGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGCGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTGGCC
Task1_train_24327
This variant affects gene KRT16 (keratin 16) located on Chromosome 17. Evaluate its biological effect and specify any disease association.
Pathogenic; Pachyonychia congenita 1
AGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTGGCCACTGGC
AGCAGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCGGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTGGCCACTGGC
Task1_train_24328
This mutation is located in gene KRT16 (keratin 16) on Chromosome 17. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; not provided
AGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTGGCCACTGGCCTT
AGCAGGGGGGCTAAAGGGTCTGGGAGGCAGAACTGAGGGGCCTGGGACTCACTGGGCATCCTCGCCCTCCAGCAGGCGGCGGTAGGTGGCAATCTCCTGCTCCAGCCGCGTCTTCACATCCAGCAAGATCTGGTACTCCTGGCTCTGCTGCTCCATCTCACAGCGTAGCTGGGCCAGCTGCTCCTCCACACTGCCAATCAGTCCCTGGATCTGGGACAGCTGCATGCAGTAGCGGCCTTTGGTCTCCTCCAGGCTGTTCTCCAGGGATGCTTTCTGCAAGTGAGAGAGAGAAAAAGAGTCCATGGAGGTGGTCACTCCTGTTCCTCCAGGTCTCTGGGCATGTTTTTTGAGAGATGCCTGGATTTTGATCCCAGTTGGGGTACTGATGGGCCAGACAATATGGAGAAAAGCTAGCCCACTATTCTAGGGCTTAGTTTCTCTATCTATATAACGGTCCCATGAGTCCCCTGGTCCCATCCTGAGAAAAGAAAGGTGGAACTAGACTGTGGCTTTTTGAGGGGGTGGTGGCCATTACTGGTGACTTGGGGGCTGCTGCTGTGCTGGGTCCTTCATACCATGCTGAGCTGGGACTGCAGCTCAATCTCCAGGCCCTGGAGCACCCTCCGGAGCTCCGTCACCTCACTGCGGCTGCTCTGTACCAGTTCGCTGTTGGAGGCCACTTCTTTGTTCAGCTCCTCGGTCTGAGGCAGGAAAGCAGAGTGAAAGGTGAGGCTCTCCCAAAGCCCCCAGCTGGGAAGTGCTGCAGGCTCACTGCGGGCCCGAGCCCCACCTTGCTCAGGAACCAGGTCTCAGCGTCTCTGCGGTTTTTCTCTGCCATCTGCTCGTACTGGTCACGCATCTCATTCAGGATGCGGCTCAGGTCCACGCCAGGTGCAGCATCCATCTCCACGTTCACATCTCCGCCGGTCTGACCTCTCAGAGCAAGCATCTCCTGGGAAGGGATGGCAGGAGGCGGTCAGTTCAGCAGACTTCTCTCCTGGCCCTGGGTGCATCTGGCAACCCCACCAAACCAGCCTCCCACCCCGGAAGCCAGCAGCGACCGTACCTCCTCGTGGTTCTTCCTCAGGTAGGCCAGCTCCTCCTTCAGGCCTTCGATCTGCATCTCCAGGTCAGTCCTGGCCAGGGTCAGCTCATCCAACACCCGGCGCAGGCCATTGACGTCGGCCTCCACAGTCTGCCGCAGGGCCAGTTCATGCTCATACCTGGCAGGACAGAGGTCAGGTCCTCAGGCTGCAGCCCTGAGGATTCTGAGGCTCGGGGTCTGCTGGCCCTGCTGGGTGGACCGCCCCACTCTTTGTCCCTTGCCCTCTGCCCCCAGCCCACCATGCTGGCTGCTCACTTGGTCCTGAAGTCATCGGCTGCCAGCCTGGCATTGTCAATCTGCAAAATGGGCTGCGCATTCTCAATGGTGGCCGCAATGATCTGGAGTGGGGATGGAGGACAGGAGCCCTGGTCAGCCAAGGACCTTACTACTTGAGCATGAAAGGCAGAAAGGGGCAAAAGGAACCGCCCCAAATCTGGAAGTCTTCTGGCTGGCAGGGCTGGCATGCCTTCTCCACCAGCTCAGGCTACGTAGGGATGCACTCCATCCCGATCACCCCCTTCCTGGGCCCAAGGCAGGGAAGCTGAACTTGCAGCTGAACCCTTGAAGGAAATAAGAGATTTAGGGTAACAGCCCCAGTCCGGGCACAGAGATACTGAAAAGGGACCCTCTGCTACCACTTCCCTGGGTGATCCTGGCCACTCCCCAAAGGTGCCCAGTCTCCCTGTTTGTAAAGTGTAATTGCTAAAAAGAGGTATCCCAAGGGCCACTGTAGCCCCAGCCTCTCTCAGTGCTCCATACACCAAAGTCACCCACCTTGTTCCTCAGGTCCTCGATGGTCTTGAAGTAGGGACTGTAGTCTTTGATCTCACTGGGCCGCTGCCTCTGGTACCAGTCACGGATCTTCACTTCCAGGTCGGCGTTGGCCTCCTCCAGAGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCCTGGTCACCTTCTCACTGCCCACCAGAAGCCCATCACCACCAGCAAAACCACCACCAAAGCCAGCACCCAAGCCACCACCGAAGCCAGCACCAAGGCCACCACCATATCCTCCCCCGAAGCCACTACCAAAGCTGCTGCTGCTGCTGAAGCCACCGCCATAGCCGCCCCCCAGCCCGCAGGCTCCCCCAGAGGAGAAGCGAGAGGAGACAGACAGGCCGCCCCCGTAGGTGCTGGGGGCACGGCAGGACCCTCCGGCCAGGACGGAGGAGATGCGGCTGGAGCCGCCCCCGATGCCGCCTCCGATGCCGCAGGAGCCCTTCATGGAGCTGGAGGAGGTGAACTGGCGGCTGCAGGTGGTCATGGTGCCAAGGAGGGAGGTGAGCGAGTGAGCAGTTGGCTGAAAGAAGGAAAGGTGCTCAGGAAGGCTGAGAGCGTGCTGTGGCTGCCTCCAACCCCAGAGACCTTTATATGCAGCTGGGGAAGGCGGGGCCCTCCTAACTGCTGACTCCAGGTTCCCCTCTGGATTTCATCACTCCCGGTCCCGTCCAACTCCTCACTCTGGATTATTCAGCCCAGGATCAACTCTGCTGTGTGCCGGCTCAGAGTTCCCACCCAGCTTTGGGGGTGTGGGGCCGAGAGAAAAACACAGAAATGCGAGTTCGGTGGTGACTCAGGCTAGGCGGTGGGGAATCAGGCTCCCTTTCCTGGAGCCCTCGGGGCCAGTCGGGCCTTGGCACAGGTGGCTTTGTGGCAACTGCGTCCCCAGGCAGTGAGTCAGCCCTTCAGAAGAACTCCCTGCCCCACAGTGACAGCCTTGGCTGAAAGAGAGCTCAGTGATGCCATCCTGGGCTGTCTTGGGGAGCAGTTGTGGGGATCCCACATGTCCCACTCTGGGCAGGGGCAGAGTTCCTGTCTTCACTCTGCTTGCTGTGTGGCCTGAGGCTCCCCACCTCCCACCTCTGGGCCTGTTTCCCCTCAGTGACCAGGCTGGACTGGGTGACTGCAGAGTCCCTTCTGTTCTAAAAATCCTATAACTCTCTTTCCCCTCTTGGATCTAATTCCAGTTCCAGAGGCTGCCTTGAGCCCCCGGGATCTCCAGAAGTGTGTGCACCATACAAACAGCACTGGCCATGGAGCTAGACAGGCGGCACTGAGTCCCTGCTCTGCCCTTACCAACTGTACAGCACAGGCTGGTCCTATAGCCCCTTGGTCCTCAGTTTTCTCATCTGTAAAAGGGGATGACACACCACTAGCCACAAAGAAACATGCGCGAAGGACCCCACCGGCCCTTCCCCGAGGGCCAGCCCTGCCCCTCAGCCTCCCCATCCTGCCCCTCCAGCCACCTGCTCCTCACACTCACCTCTACACACTGGCACCATCCCGCACCCCTAAGCAGGGCCCTGCGCCCCCCACACTCCCAGCTGAAGAACACCACAGCCCCACACCTAGCTCTGCCACTCCTCTACCGCCCTCTCCTAATCACAGGCACCCCACCTGCAGGCTGGTGGGAGGGAGCCCCATCCTGCCACTACAGCCAGGTATGACCCCTGACCCCACCTGGGCCTCAGAGTCCCCCCCTACCCTGTAGAAACAGGACTAGCCGGGGATCCGTTCCCAGCAGTTCTCTCTCCTGTGTCCACAGATCCCAGGCTAGGCCTGGCAGCTCCATTCATCCAGCTGAGCTGGGGGAGAGCACTGGTTATGGGCCCACTCAGGCATGCATGGAGAGCCCAGTGTGTGCCATACAGTTCTGTGAGCGTAGAGATTCACTCAAAGTCACTCTGCTTTAAGCTGCAGAGCTGCAACTAGAACCCAGAACTCTGGCCCTCTCCAGGCTCCCACCATGCCTGCAGGCGGGGCCAGTATACCCAACTCTCACCCACCTCCCCACGATCACTGGCAGGAGGTCTGCCCATGGTGGGCATGGCCTTGGCCTGAGAGCCTGGTCCAGCACCGAGGACTGGAGGGAGGATGGAGGGGTCTGGGCACCAAGACGGGGCCTCCTCAGGGTGCTGTGGGGCATCCCTCGGTGCTGGCCACTGGCCTT
Task1_train_24329
The variant affects gene KRT17 (keratin 17), which is on Chromosome 17. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; not provided
GAGGTTCCTTGTGTACAGAGAAGCAGTGTGGTACAAAGAGGAGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAA
GAGGTTCCTTGTGTACAGAGAAGCAGTGTGGTACAAAGAGGAGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTCGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAA
Task1_train_24330
A genomic change on Chromosome 17 affects KRT17 (keratin 17). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; Pachyonychia congenita 2
AGCAGTGTGGTACAAAGAGGAGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAAT
AGCAGTGTGGTACAAAGAGGAGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCATCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAAT
Task1_train_24331
This variant affects the gene KRT17 (keratin 17) found on Chromosome 17. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; not provided
GGTACAAAGAGGAGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCA
GGTACAAAGAGGAGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCGGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCA
Task1_train_24332
Given this variant in gene KRT17 (keratin 17) on Chromosome 17, classify it as benign or pathogenic. Include the disorder it may cause if applicable.
Pathogenic; Pachyonychia congenita 2
CAAAGAGGAGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTC
CAAAGAGGAGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTCGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTC
Task1_train_24333
This alteration in KRT17 (keratin 17) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; not provided
AGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTC
AGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCGGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTC
Task1_train_24334
A variant has been detected on Chromosome 17 in KRT17 (keratin 17). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Pachyonychia congenita 2
AGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTC
AGTCTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCTGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTC
Task1_train_24335
Gene KRT17 (keratin 17) on Chromosome 17 is altered by this variant. Does this mutation result in a disease or is it benign?
Pathogenic; Pachyonychia congenita 2
CTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCT
CTGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGGGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCT
Task1_train_24336
Gene KRT17 (keratin 17), found on Chromosome 17, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Steatocystoma multiplex
TGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTC
TGCCCTGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCAGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTC
Task1_train_24337
A variant affecting Chromosome 17, within the gene KRT17 (keratin 17), has been observed. Determine if it's benign or associated with disease.
Pathogenic; Pachyonychia congenita 2
TGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCC
TGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCACTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCC
Task1_train_24338
This alteration in KRT17 (keratin 17) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Abnormality of the skin
TGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCC
TGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCACTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCC
Task1_train_24339
Given this context: Chromosome 17, gene KRT17 (keratin 17) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; Steatocystoma multiplex
TGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCC
TGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCACTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCC
Task1_train_24340
The gene KRT17 (keratin 17), on Chromosome 17, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; Pachyonychia congenita 2
TGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCC
TGCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCACTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCC
Task1_train_24341
A variant was discovered on Chromosome 17, affecting KRT17 (keratin 17). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; not provided
GCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCCA
GCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATCGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCCA
Task1_train_24342
A variant on Chromosome 17 in gene KRT17 (keratin 17) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Steatocystoma multiplex
GCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCCA
GCACACTGGACCCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATGGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCCA
Task1_train_24343
This alteration in KRT17 (keratin 17) on Chromosome 17 may affect gene function. Does it lead to a disease or is it benign?
Pathogenic; Pachyonychia congenita 2
CCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCATGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCCACACTGCCCCAA
CCCAAGGATCAGGGCTCTGCAGACAGGGAAGCCCTCTAAGGTGACTAATCCCGGTGCACCTGCTCTGCTCTCTCCCACGGCCTCAGCCATTGCCCAGCCCCAGGGCTCTGCCACCCACTCCTCAGCATCTTTGACCTTCTGCCCCAGCCACCTCACCTCCTCGTGGTTCTTCTTCAGGTAGGCCAGCTCCTCCTTGAGGTTCTCAATCTGCATCTCCAGGTCGGCTCTGGCCAGGGTCAGCTCATCCAGCACCCTGCGCAGGCCATTGATGTCGGCCTCCACACTCAGGCGCAGGGCCTGCTCTGTCTCAAACCTGCCGTGGGAATCAGAGACTTCAGCCCAGGCTGCTTGGACCTGCAGATCCAGGTCCTGGCTGCTCACCTGCCTTCATTTTGCCAGGACTCTAAGGAGTTGGAAGGGCTGATGAGAGGGTCGAGTGGAAACGAATTCCAGCCCCGGGACCCCGGGACCATCACAGGGCCAGATCCCACGCCCACCAGCTTCCTTACTTCTCTCTGCCTCCCGCCTCCCGCCTCCCCTCCTTCTCTTCTATTCCCTGCCTAAGCTCAGCAACCTTCAGAACTGGCTGCCTTCACTGCATCCTGGACTAAGGAGTGGGGCTCCTAGGACTGCCCCACCCTGAGCTCCTGGGCCTTGCCACAAGCAACCAAGGAATCCTGGGGTCAGGAGGGGTACCCTGAGATCCTCCGCCAGCTGGCCCAGGCTGCCCAAGGCCACAGCTAGGACTCACTTGGTGCGGAAGTCATCAGCAGCCAGACGGGCATTGTCAATCTGTAGCAGGATGTTGGCATTGTCCACGGTGGCTGTGAGGATCTGAGGAGAAGGGAGAGTAGTCAGGTCATTGGATGGGGGTGGCTGAGCCCACACCAGGGTTCTGAGCAGATCTTCCTGCCTCAGGGCCTCTCTTCTCGCCCAGCCCCTCCCTTGCCCCGTGCTGTATTATTGGCAGAGGAGGGGCAAACAGGAGTCTGAAGGGCTGAAAGGTGCCTCTTCTTCCCCCGATACTCAGTACCCCACCAGACCCCCATGGCAGGCTCGGCCTTAAAGGAGAAGAGACAGCTGGCTGGGAGTATGAGGCAACCAGAAAAGAATGGGAAAATGTCCCCAGGGCAGAAGCTGTCCCAGAATTCTAGAACAAGGGAGGGGATGTGGGCAACCCCCTCGTTTTACAGTCAGCTAGAGGGTGCCCCTGACAGGCTCCCCCAAAAGGAGGCTAAAGGAGCCCTCATTAAAGAGTGGTTCCAAATCAAAAGTCAGGACCCCTCCTAATCCCTAACCCTGGGCGCCAGCCAGCAGCCCCGCCCCCTGGGGTTTGCTGAGCCCGTCTTAAGGGACAGCAGGAGGAAAGGAGAAGCCAGAAAAATCCCCAAATAAGGCACATCAGAGGCCTTCCCCACACTGAGGTCCCGCCCCCTCCTTTCTGCCTCCTCCTGCAGCAGGTGCTATCAGGAGCTCACTCAGACACCCCCACTCCACATCACCCAAAACCCCCTCCTGTTGACCCCTGCTCCAAAGGAGCAAGACACCACACATCCAGCAGCCCACGGGCCCAGCCCTCCATCTGCATCCTCCTGCCTCATCCTACAACCTCTCCAGGTGGCGGAGCTCCACGAGGGAGAAACTGAGGCTCCAAGGGGCTCCACAAGGCCTCTTTGTTCCTGACTCAGCTTGCTGTCCCCAGAAAAGGGGGATGTGAGCCACACAGGGGCCCCAAGGCAGGTTCCCAGAAGCTAAGCCACAGCCAAACCACCCTTGGCTCCCTGAGACCCTATGGCTGGACTCCAGGCCTTTGGCCAAGGCAGGAGTTGGGGGGAAGAAGTCATGCCCCCCGGAGACCCCTCCCACCAGCAGGCCCTACCTTGTTCTGCAGCTCCTCAATTGTCCTGTAGTACTGGCTGTAGTCACGGGCGGGCCCCGGGGCCTGCCTCTGGTACCAGTCACGGATCTTCACCTCCAGCTCAGTGTTGGCCTCCTCCAGGGCACGCACCTTGTCCAGGTAGGAGGCCAGGCGGTCATTGAGGTTCTGCGTGGTGGCCTTCTCACCTCCAGCCAGCAGCCCATCAACACCCCCAAAGCTGCTGCCATAGCCACCACCAGAGCCAAAGCTGTAGCAGCTGGAGTAGCTGCTACCCCCGAGGGTGCTGCCCAGGCCGCCAGCAGATCCCAGCCTGCAGGAGCCGGCACCCAGGCCGCCAGACAGCCGGCAGGAGGTGCGGGACGAGCCGCCCCCCAGGCCGGAGGAGCCCTTGATGGAGCTGGAGGAGGTGAACTGGCGGATGGAGGTGGTCATGGTGGCGGCGGCAGGAGGCAGGCACACAGGAGAAGGGCTGGAGAGGAGAGGGGCCCCAAGTTGTGTAGGGCTGCCGGGGTTCGCCCGCTTCCTTTATAGGCCACCAAGTGGGCGTAGCGATTACAACAGGCTTGCTCCTCTGTTTCCATTCCCCTGGGCTTTCATCACCACTGGCCACCTGCCAGCTCCCAGGTGGCTGGGGGCCCCCTCCCCGCCCATCATCAGGAATTTGCCTCATTTCTCCAAATCCTCGTGCTGAGTGCCGTGCGTGTGCGTGCCTCTGGTCTCAGGCCCGTCACCTGTGATTCAGGCGGGCCCTCCAGCTATGCTTTCCCATGACCTAATACGGAGAAGAGGAGAAGGCAGGACGTCACCGTCCCCAGGCCCTCCCAGGCAGCCACCACCCCAGCCTGGCCCGCCTCAACCCTGTCTGGTGGGGAAATGGGTTGCAGTGTCAGCTGACCCCCCCGCCAAAGTTGCTGTCTTTCACCCCACACTGCTCCACCCACGGTGCTGGCCCCGGGGCTGGGTGCTGAAGAGAAAGAGGAGACCGAGAGCCTATCCTGCCTTGGAAACTGAGCCCAAACCCACCAGGCCCACCTCACAGCATAGAAATGCCATCAAGCCTCGGAGACCAACCCACATCACAGATAAAGAAATTGGGGCTCCAGAGGGGTGCCGTGTCCACACTGGCCCCTTCTGCAGAGCCTGACACCCAGGAATGCACTCTAGGGGCTACAGTTCCATCCAGTCAGCTTCTGACCCTGCCCCATCCCTAGAAATCCTTGCTAACCCAGTCTCTTCGTGTAAACCTTTCCCCAGGTTTACACTCCAGGCTGGGGTGGGCAAACAGGGGCTCAGCTATAGGATGGGGAAATGGTGGGCTGTGCCAACTGAGAGGGGGATGCCCCCTTCCACTCCCCTCACCCTTCTGTACCCCAAGAGACCTCAGGGTCAGGTGACGGGTATTTATCTCAGGTCTCAGCCCACAGGAAACCTAAAGGACATTGCCCAAGAAGAGGCTCTTACAGAGACCCCAGCCAGCCCCCTTCCCACTCCAGGCTCCCCAAGATGTGGCTCCTCAGGTGGGCCATGTGCCCCACCCCACAGCCCCACCCTGCCCTGCCCACCACCCCAAGCCCGGCCCTGGGTCCCAGGGTCCCGCCAGGCCCGCTGGGTGGAATGTGGTCATGTTTCAGACTGCCGATGGCTTCCACTTCCCAGACAGGCCCAGACGGCCCCGCCAGCAGCCGAGAGACATTCCTCAATAGCCCAGTGGCTGCCAAGCCACCAAAGCAAACAGGATGCCCCCTACGCGTACACGCACAGCGGCCACCCCGCCCCACACACACCCCGAGCTGGGGCAGAGCCGGTCTGGTTTCCTGGGCTGGCTGCGTCACTGCCATGCCCTCTCACTCATCAATGCCATGGACCACTCCTTCAGAAGCCCCTCCCCACCAAGCCCCTCTCCTTCTGCTCTTGAACCCGCCCTGGGCTGAGGCAGGGAGTGCTCCCCAACAGGCACCATCCTTGGAAAGTCTGTGTGGCCCTCCCAGGGACCAGCCACAGGTGACAGGGACTCAGGGGCTGATTCTTAGAAACTTTTCCCAATACAAGGGGCTGTCCCATCCCTCCACCCTTAATCTTTCCGCCTCCTCCCCTCTCATCTTTCCAGGAGCCCCAGGCCTGGATGGAGTGGGCAGAACAGATTGGCAGGTGACAAGCCCATACCCAAACACTCAATAAACTCCACCTCCCCCAGTCCCTCAGCCCACACTGCCCCAA
Task1_train_24344
This sequence variant lies in KLHL10 (kelch like family member 10) on Chromosome 17. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Spermatogenic failure 11
GCCTGTAATCCCAGCTACTCGGGAATCTGAGGCAGGAGAATAACTTGAACTCAGGAGGCGGAGGCTGCAGTGAGCCCAGATCGCACCATTGCACTCCAGCTGGGCGACAGAGAGAGACTTGGTCTCAAATTAACAAAAAAAAAAAAAAAAATCTTAAGTATTGCACACAATTGTTGTCAGTTGGTGCTAATAAGCGTTATTTTACATATTAAGACATACTCAATTACTGAACAATTACCATGGTTTTTCTTGGTCTAATAGTACTGACCACTAACCAAGGAATGGGATTGCTCTCTGGCCACTTGAGGTGCCTTCTATCTAGCTCATTCTCAGCTTCCAAATGTATATATCACCTCCCCATAAATAAATAGTAAATAAATATTTATTATTTATTTATTTATTTTGAGAAGGAGTCTCACTGTTGCCCAGGCTGGAGTGCAGTGATGCGATCGCGGCTCACTGCAACCTCTGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGGCTCCCCAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCAGCTAACTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTAGCGCCCGGCTGACAACTATTTATTTATTTTGAGACAAGTCTCACTCTGTCACCCAGGCTGGAGTGCTGTGGTGTGATCACAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCACACCTTAGCCTCCAGAGTAGCTGGGACTACAGGCACGCGGCACCATGCCTGGCTAATTTTTTTTTTTTCTTTTTTTTTGAGTTGGAGTCTAGCTCTGTTGCCCAGGCTGGAGTGTGGTAGCACGATCTCGGCTCACTGCAACCTCCACCTCCCCAGTTCAAGCGAGTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACCTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGGTTTCACCACGTTGACCAGGCTGGTGTCAAATGCCTGACCTCAAGTGATCTGCCCACCTCGGCCTCCCAAAATGTTGGGATTGCAGGCGTGAGCCACTGCACTCAGCCTGGTTTTTGTATTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTGGCCCAGGCTGGAGTGCAGTAGGGTGATCTCGGCTCACTGCAACCTCTGCCTCCCTGGCTCAAGCGATTCTCTTGCCTCAGCTTCCTGAGTAGTTGGGATTACAGGTGCGTGCCACCACACTCAGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTTGCCATGTCGGTTAGCCTGGTCTAGAACTCCTGACCTCCGGTGATCCGCCCATCTCGGCCTCCCAAAGTGCTGGGATTACGGCCGTGAGCCACCTCGCCTGGCCCCAATTTTTGTATTTTTAGTAGAGACAGGGTCTTGCTATGTTGCCAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCCACCTGCTTTGGCCTCCCAAAGTGCTGGGATTATGGTGTGAGCCTCAAAATCGACTATTTAAACTGTGACTTATACATTTCAAAAACAAACCAAAATATTTCCAGCAATTCAAAGGCAGATCGAAAAATGGGAGTTAAGGATGTGGGATTTCCTGGCACTCTCACGTCACCTGAATGACTTTCTGCGTTTGCTTCTTAGGTTCGCCTGGCCCTAATGCATGCTGAGTACTTCATGAACAATGTTAAGATGAATGACTATGTCAAAGACAGTGAGGAATGCAAACCAGTCATCATTAATGCCCTAAAGGCCATGTATGACCTCAACATGAATGGACCCTCTAATTCTGATTTCACCAACCCACTCACCAGACCACGCTTGCCCTATGCCATCCTCTTTGCAATTGGTGGCTGGAGTGGTGGGAGCCCCACCAATGCCATTGAGGCATATGACGCTCGGGCAGACAGATGGGTGAATGTTACTTGTGAGGAAGAGAGTCCCCGTGCCTACCATGGGGCAGCCTATTTGAAAGGCTATGTGTATATCATTGGGGGGTTTGATAGTGTAGACTATTTCAATAGTGTTAAGCGTTTTGACCCAGTCAAGAAAACTTGGCATCAGGTGGCCCCGATGCACTCCAGACGTTGCTATGTCAGTGTGACAGTCCTCGGCAATTTTATTTATGCCATGGGAGGATTTGATGGCTACGTGCGTCTAAACACTGCTGAACGTTATGAGCCAGAGACCAATCAATGGACACTCATCGCCCCCATGCACGAACAGAGGAGTGATGCAAGCGCCACAACACTTTATGGGAAGGTAAAGGACCAGGGTGGGAGGGGAAGATGTGGATGCAAAGTACAAGACCAGAAATGATACTGCTCTTTTTTGGGGTGGATGGAAGACGCAGTGGCAGTATTCACTTTGGAGTACTCATTCTTTCTTCAATTGACAAGGTGACTAGTTGCAACTGTCTTTTATGTTGTTTATTGAAAAGTAATGCAAAGCCGGGCACGGTGGCTCAAGCCCGTAATCCCAGCACTTTGGGAGGCCGAGGCAAGCAGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATAGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCAGGCCTGGTGGCGGGCGCCTGTAATCCCACCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCCGGAGGCAGAGGATTTCAGTGAGCCAAGATGGCGCCATTTCACTCCAGCCCGGGCGACAGTGCAAGACTCCATCTCAAAAGAAAAAAGAAAAAAAAAGTAATGCAGGCTGGGCTCGGTGACTCACGCCTGTAATCCCAGCACTTTGGCAAGCCGAGGCGGGAGGATCACAAGGTCAGGAGATTGAGACCATCCTGGCTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCGGAGAATCACTTGAACCTAGGAGGCGGAGGCTGCAGTGGGCAGAGGTTGCAGTGCTCCAAGATTGCGCCACTGCACTCCAGCCTGATGACAGAGCAAGACTCCGTCTCCAAAAAAAAAAAAAAGTAATGTGTAATGTGGCAGAGCCCAGTGTCTTGTGTTTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACTTGAGGTCAGGAGTTTGAGACCAACCTGGCCAACATGGTGAAACCCGGTCTCTACTAAAAATACAAAAATTAGCCAGGCACAGTGGCACACACCTGTAATTTCAGCTACTCAGGAGGTGGAGGTTGTAGTGAGCCGGGATAGCTCCACTGCACTCCAGCCCAGGCAACAGAGTGAGACTCCATCTCAAAAAATAAAAATAAATAGGCTGGGCACAGTGTATCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGAGGGGCGGATTGCCTTAACTCAGGAGTTCGAGACCAGCCTGGACAACACGGTGAAACCTCGTCTCTACTAAAATACAAAAAATTAGCGGAGCGTGGCAGTGTGCGCCTGTAGTCCCAGCTACTCCAGATGCTGAGGCAGGAGAATTGTTAGAACCCAGGAGGCGGAGTGAGCAGAGATGGTGCAAATGGACTCCAGCCTGGGTGACAGAGCGAGACTCTGTCTCTAAAAAATAAATAAAAAGCAATGCATGCACATACAAAAAAAAGAAATTCAGACTGTACAGACTGGAATTAAGTGCCCACTACCACCACACACATATCCTTTCTTTCTACTCCCTAGAGTGGGAATTTTAATAATCTTGGAACTCTTCACACAGGTCTACATATGTGGTGGGTTTAATGGAAACGAGTGCCTGTTCACAGCAGAAGTGTATAACACTGAAAGTAATCAGTGGACAGTCATAGCACCCATGAGAAGCAGGAGGAGTGGAATAGGCGTGATTGCTTATGGAGAACATGTATATGCGGTAAGTTTATCTAGTACCACACACACACAAAAAACACATTACCCCTAGATTTTGTATTAGTAA
GCCTGTAATCCCAGCTACTCGGGAATCTGAGGCAGGAGAATAACTTGAACTCAGGAGGCGGAGGCTGCAGTGAGCCCAGATCGCACCATTGCACTCCAGCTGGGCGACAGAGAGAGACTTGGTCTCAAATTAACAAAAAAAAAAAAAAAAATCTTAAGTATTGCACACAATTGTTGTCAGTTGGTGCTAATAAGCGTTATTTTACATATTAAGACATACTCAATTACTGAACAATTACCATGGTTTTTCTTGGTCTAATAGTACTGACCACTAACCAAGGAATGGGATTGCTCTCTGGCCACTTGAGGTGCCTTCTATCTAGCTCATTCTCAGCTTCCAAATGTATATATCACCTCCCCATAAATAAATAGTAAATAAATATTTATTATTTATTTATTTATTTTGAGAAGGAGTCTCACTGTTGCCCAGGCTGGAGTGCAGTGATGCGATCGCGGCTCACTGCAACCTCTGCCTCCCAGGTTCACGCCATTCTCCTGCCTCAGGCTCCCCAGTAGCTGGGACTACAGGCACCCGCCACCACGCCCAGCTAACTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTCGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCTAGCGCCCGGCTGACAACTATTTATTTATTTTGAGACAAGTCTCACTCTGTCACCCAGGCTGGAGTGCTGTGGTGTGATCACAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCACACCTTAGCCTCCAGAGTAGCTGGGACTACAGGCACGCGGCACCATGCCTGGCTAATTTTTTTTTTTTCTTTTTTTTTGAGTTGGAGTCTAGCTCTGTTGCCCAGGCTGGAGTGTGGTAGCACGATCTCGGCTCACTGCAACCTCCACCTCCCCAGTTCAAGCGAGTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTATAGGCACCTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGATGGGGGTTTCACCACGTTGACCAGGCTGGTGTCAAATGCCTGACCTCAAGTGATCTGCCCACCTCGGCCTCCCAAAATGTTGGGATTGCAGGCGTGAGCCACTGCACTCAGCCTGGTTTTTGTATTTTTTTTTTTTTTTTTTTTTTTTGAGACGGAGTCTTGCTCTGTGGCCCAGGCTGGAGTGCAGTAGGGTGATCTCGGCTCACTGCAACCTCTGCCTCCCTGGCTCAAGCGATTCTCTTGCCTCAGCTTCCTGAGTAGTTGGGATTACAGGTGCGTGCCACCACACTCAGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTTGCCATGTCGGTTAGCCTGGTCTAGAACTCCTGACCTCCGGTGATCCGCCCATCTCGGCCTCCCAAAGTGCTGGGATTACGGCCGTGAGCCACCTCGCCTGGCCCCAATTTTTGTATTTTTAGTAGAGACAGGGTCTTGCTATGTTGCCAGGCTGGTCTCAAACTCCTGGCCTCAAGTGATCCACCTGCTTTGGCCTCCCAAAGTGCTGGGATTATGGTGTGAGCCTCAAAATCGACTATTTAAACTGTGACTTATACATTTCAAAAACAAACCAAAATATTTCCAGCAATTCAAAGGCAGATCGAAAAATGGGAGTTAAGGATGTGGGATTTCCTGGCACTCTCACGTCACCTGAATGACTTTCTGCGTTTGCTTCTTAGGTTCGCCTGGCCCTAATGCATGCTGAGTACTTCATGAACAATGTTAAGATGAATGACTATGTCAAAGACAGTGAGGAATGCAAACCAGTCATCATTAATGCCCTAAAGGCCATGTATGACCTCAACATGAATGGACCCTCTAATTCTGATTTCACCAACCCACTCACCAGACCACGCTTGCCCTATGCCATCCTCTTTGCAATTGGTGGCTGGAGTGGTGGGAGCCCCACCAATGCCATTGAGGCATATGACGCTCGGGCAGACAGATGGGTGAATGTTACTTGTGAGGAAGAGAGTCCCTGTGCCTACCATGGGGCAGCCTATTTGAAAGGCTATGTGTATATCATTGGGGGGTTTGATAGTGTAGACTATTTCAATAGTGTTAAGCGTTTTGACCCAGTCAAGAAAACTTGGCATCAGGTGGCCCCGATGCACTCCAGACGTTGCTATGTCAGTGTGACAGTCCTCGGCAATTTTATTTATGCCATGGGAGGATTTGATGGCTACGTGCGTCTAAACACTGCTGAACGTTATGAGCCAGAGACCAATCAATGGACACTCATCGCCCCCATGCACGAACAGAGGAGTGATGCAAGCGCCACAACACTTTATGGGAAGGTAAAGGACCAGGGTGGGAGGGGAAGATGTGGATGCAAAGTACAAGACCAGAAATGATACTGCTCTTTTTTGGGGTGGATGGAAGACGCAGTGGCAGTATTCACTTTGGAGTACTCATTCTTTCTTCAATTGACAAGGTGACTAGTTGCAACTGTCTTTTATGTTGTTTATTGAAAAGTAATGCAAAGCCGGGCACGGTGGCTCAAGCCCGTAATCCCAGCACTTTGGGAGGCCGAGGCAAGCAGATCACTAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATAGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCAGGCCTGGTGGCGGGCGCCTGTAATCCCACCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCCGGAGGCAGAGGATTTCAGTGAGCCAAGATGGCGCCATTTCACTCCAGCCCGGGCGACAGTGCAAGACTCCATCTCAAAAGAAAAAAGAAAAAAAAAGTAATGCAGGCTGGGCTCGGTGACTCACGCCTGTAATCCCAGCACTTTGGCAAGCCGAGGCGGGAGGATCACAAGGTCAGGAGATTGAGACCATCCTGGCTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCGGAGAATCACTTGAACCTAGGAGGCGGAGGCTGCAGTGGGCAGAGGTTGCAGTGCTCCAAGATTGCGCCACTGCACTCCAGCCTGATGACAGAGCAAGACTCCGTCTCCAAAAAAAAAAAAAAGTAATGTGTAATGTGGCAGAGCCCAGTGTCTTGTGTTTGTAATCTCAGCACTTTGGGAGGCCAAGGTGGGCGGATCACTTGAGGTCAGGAGTTTGAGACCAACCTGGCCAACATGGTGAAACCCGGTCTCTACTAAAAATACAAAAATTAGCCAGGCACAGTGGCACACACCTGTAATTTCAGCTACTCAGGAGGTGGAGGTTGTAGTGAGCCGGGATAGCTCCACTGCACTCCAGCCCAGGCAACAGAGTGAGACTCCATCTCAAAAAATAAAAATAAATAGGCTGGGCACAGTGTATCATGCCTGTAATCCTAGCACTTTGGGAGGCTGAGAGGGGCGGATTGCCTTAACTCAGGAGTTCGAGACCAGCCTGGACAACACGGTGAAACCTCGTCTCTACTAAAATACAAAAAATTAGCGGAGCGTGGCAGTGTGCGCCTGTAGTCCCAGCTACTCCAGATGCTGAGGCAGGAGAATTGTTAGAACCCAGGAGGCGGAGTGAGCAGAGATGGTGCAAATGGACTCCAGCCTGGGTGACAGAGCGAGACTCTGTCTCTAAAAAATAAATAAAAAGCAATGCATGCACATACAAAAAAAAGAAATTCAGACTGTACAGACTGGAATTAAGTGCCCACTACCACCACACACATATCCTTTCTTTCTACTCCCTAGAGTGGGAATTTTAATAATCTTGGAACTCTTCACACAGGTCTACATATGTGGTGGGTTTAATGGAAACGAGTGCCTGTTCACAGCAGAAGTGTATAACACTGAAAGTAATCAGTGGACAGTCATAGCACCCATGAGAAGCAGGAGGAGTGGAATAGGCGTGATTGCTTATGGAGAACATGTATATGCGGTAAGTTTATCTAGTACCACACACACACAAAAAACACATTACCCCTAGATTTTGTATTAGTAA
Task1_train_24345
The gene CNP (2'',3''-cyclic nucleotide 3'' phosphodiesterase) is located on Chromosome 17, where a mutation has occurred. What is the medical relevance of this mutation?
Pathogenic; Myopia 2, autosomal dominant
TGAACAATGGGATACCTGCCTCAGGGGTTGCTGCGAGGACTGAGTGCTTAGCACAGCACTTGGACAGGAAACTCAAAAATCCAACGGAGCTCTCAGTGGTTTCACAGAGGAGGTGGCAGCTGAGGATCTGGCCTCAGAGGATGTTAGGATTTCACTCCGTTACTCATCTGTCCCTTTGGCCATTGCCATCCTGGTCTGTCTCCACAGCTCCTAGAAGGAAAGGTCGGGGCTGAGACTGACTTTCGGCTGGCACAGGGCCTGGACGAATGAGGCCAGTGAGGCATTTCAGATGCAGAGTTTACCGGAATGCCAGCAAATTGCATGATAATATTTTAATCCAATGTGGTAAAAAAAAAAGTTTTTAATTAATGCAAAAGTCCATGATGAATAAAATATCAAAAATTAAAGACAGGATCCGACTTTGCACGACCCTGCCTCACTCACTTCCTGCTAATCCACGGGACCGGGGAGGGTGACTGAGTTACCCCTCAACACGCAGAAAAAGCTAGTGGCCGCTCAGCTCGCAGGCGCAGTGGGTGGGTGCGCGTGGGGAGCAGGCGCGCGCAGGGGGCGGGACCGGGCCGAGGTTCCCGCGCGCGGCGAGAGTTTCGGGTTTTGGTTCGCAGCGCCTGCGCGCAGAGGAGACGGCCCGCCCCCAGCCCGCCCGGGTGCCCGCTCCGCCCCCCGGGCTATGTAAAGCGGCCGGGCTCGGGTCGTGCCACCGCTGGACTCCCGTGTCCCTCCGCGCAGGCGGGCGGCCCCGGAGCGCTGGTGCCGGCAGAGGCGGCGACGGTGGCGCCCCTCCTCATCATGGTGAGAGGCCGGGCGGGGCCGGGCACGGGGTAGCACCAGGGCGGGAAACGAGTGTCGGGGCCCCTCGGGAGGAAGCGTCTTGCAAACGAGGACCCGGGGCTCCGGGTTCGACTTCCAGTTTTCTTGGTACTCAGGGCGGCCCTGAGGTCTGGGAGAAGCGGAGGGGTTTTGGGGTGCCGGAGAGGCCGCTGTAAAGGGAAACGGTGGTGTTTCTCAGGAGGGAACTCGGGACCGCAGAAGCTGCTGCGCCTCTGGGAGCCTGGGTGGGCCTGGGCCGGGAGCCCGGGAGCTGCTCCCGACCCCACGCAGGCCCGCGCTGGGGCAGCCGCTTCGGCGCCCCCTCCCCGGGCCCAGTCTCATCACGCGGAACCGCTGCCCCGCGCCCGGGTGCGGGCGGGAGGTGGAGCCAGTTCAGAGGAGGGGACCCTTTACGGTAAAAGCTGCCGTCCCTTGTGGCTTCTAGAAGATAGGAAAACAAGTGGCTCCGAGAGGCGCTTCTGACACACAGCACAGCGGCGGGTAGAGCTGGATCCTAATTGCAGGTGCCCTGTGCTGCCCTGTTCTGGACAGGCACAAAGACCACGACTTTGTGGGGGCCGGGAGAGGGTAGAGGAGGAGGTGGCAGGCTTGGTGAAAGAGGGCCTTTGTCCAGTGCTCTCCTGCCCTGCCCCCCACCAGCCCTTCTGTGGGACCATTGTACCCGCATGCCAGACAAGAGAGTATTATCTGTTGCGGCCATTGTTGGGGGAAGGGAGGCAGTCTTGGGGTAACCCTTCTCCACTCCCCCCCTTCTCTGTGCACTCAGCCGTGGCAGCTGTGGCTTGGCCCAGACACAGAGACCCCCACCTCCAAAGAGGACGTCCTTAGTAGGTGCCAAGCATATAAGAGTGAGGCCAGTCCCAGAACCGCAGGCTCCTGGCGCGCCCCGCATGCCTCCAGCACGTTTACCTTTCCGAAGTGGCAGGAATGGGGAAAGCGCACGCTTAGGAGAGCTTCAGACAAGCTTCCCTCTTCCTCCTCCACGACCAGAAGCGGAAAGGTGCTCCCGGACCGAAAGGGAAAGAAGGTCCAGCACTGCCCCGCTTGGGAAGGCACCCACAACCAGTCTAGGGACTAGGGGTAAGGCCGGCGGGGAGCCCGCGAATGACCTGGGCTGACATCTCTTCCCCTCCTTACACAGAACAGAGGCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAAGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAGGACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCACGGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCGAGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACACCAACCACGAACGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAGAAGGAGCTGCGACAATGTAGGTGGCAGGTTGGGGCCTTATAAGCCCACCTTGCTGGGCACAGGGTGCTGCGGGCAAAGGACCATCATTGTACTCAAAGGATGGAGCACGAAGCAGCAGGAGGCAGAGAGAGGCTCACCTCAGCGGGGGCAGGGGCAAGCGGTGCGTCCCAGTGGTAGCCTTGGGGAGTTGGCAGCACATTGGGAACACGGGGGCTTCCCAGAGCGCCTTTCCTCCCACCACACCTATCCTTCTAGCCCTCTTCTCTCCGACACCCTTTTCCCAGCCTGAATGTAGACCACTGTCCCTTGTCTTGGAGGTGGGAAAAACAAATTACTGTAGTAACAGGAAACATGTCCTCTTCTAATGTAACCTTAGAGGGGGAATCAAGCCCAGTGTTTTCCAACGCATTTTTAGCAGCAGAATCATGTTCCAAAAAATAATAATAATAATCACATGAAATTGTAAGCTGCAAAAAAATTAAAACTAGGACTATTGTGGCTTCACTGGGGATGGTTCTCAGGCCTCGGACTGCTCAATTTACTCATGGGTTTGTGGCATCTGCAGCTCCAGAGGACACAAGTCTCACACTTAGGCCAAAACCCGTTTTCAGATGGAAAAACATGGACCCAGGAGGGATGTGGGGTTTACGGGCTGGAACCCTGGACTCTGGCCACTCTAGCAGGGTTCTCTCTTGGCATGGGCTTTTTGCTCCAATGATAGGTTTGAGATAAAGAAGGGTCCTGGTGGCTCTCCTGGAGTGACCTGTTGGAGAAGTGCCACCCACTAATCCATCTATATGCCTTTAGGCCATTTCTGGTTGCCTCCAATTTTATTTATTTATTTATTGTGACACGGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCTATCTCAGCTCAGTGCAACCTCTGCCTCCCAGATTCAAGCAATTCTCCTGCCTCAGCCTCTCGAGTAGCTAGGACTACAGGTGTGCACCACCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACAATGTTGGCCAGGCTGGTATTGAACTCCTGACCTCAGGTGATCCGCTTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACCGCACCCAGCCACCCCCAATTTTAGATGATCTTCATGCCTGAAATAGCCCCACTCTGGTTTGTTGACATTGTGTATATTGCACAGAAGCAGGGAATTTGTGCCTGTATGGGTTCTCAGAGAGCTTTTTTCTCAGCTCCTAAACTTGAACTCTGCAGTGAACTGTGGTGCTTGCAGTGACATTGGCCAGGAGCAAGCCCTGTACCTGTGAGCTGGTGGCTCTGCCCTGGAGTGACTACTGCTCAAAGTTGCTTTTAATATTTATTTATGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTC
TGAACAATGGGATACCTGCCTCAGGGGTTGCTGCGAGGACTGAGTGCTTAGCACAGCACTTGGACAGGAAACTCAAAAATCCAACGGAGCTCTCAGTGGTTTCACAGAGGAGGTGGCAGCTGAGGATCTGGCCTCAGAGGATGTTAGGATTTCACTCCGTTACTCATCTGTCCCTTTGGCCATTGCCATCCTGGTCTGTCTCCACAGCTCCTAGAAGGAAAGGTCGGGGCTGAGACTGACTTTCGGCTGGCACAGGGCCTGGACGAATGAGGCCAGTGAGGCATTTCAGATGCAGAGTTTACCGGAATGCCAGCAAATTGCATGATAATATTTTAATCCAATGTGGTAAAAAAAAAAGTTTTTAATTAATGCAAAAGTCCATGATGAATAAAATATCAAAAATTAAAGACAGGATCCGACTTTGCACGACCCTGCCTCACTCACTTCCTGCTAATCCACGGGACCGGGGAGGGTGACTGAGTTACCCCTCAACACGCAGAAAAAGCTAGTGGCCGCTCAGCTCGCAGGCGCAGTGGGTGGGTGCGCGTGGGGAGCAGGCGCGCGCAGGGGGCGGGACCGGGCCGAGGTTCCCGCGCGCGGCGAGAGTTTCGGGTTTTGGTTCGCAGCGCCTGCGCGCAGAGGAGACGGCCCGCCCCCAGCCCGCCCGGGTGCCCGCTCCGCCCCCCGGGCTATGTAAAGCGGCCGGGCTCGGGTCGTGCCACCGCTGGACTCCCGTGTCCCTCCGCGCAGGCGGGCGGCCCCGGAGCGCTGGTGCCGGCAGAGGCGGCGACGGTGGCGCCCCTCCTCATCATGGTGAGAGGCCGGGCGGGGCCGGGCACGGGGTAGCACCAGGGCGGGAAACGAGTGTCGGGGCCCCTCGGGAGGAAGCGTCTTGCAAACGAGGACCCGGGGCTCCGGGTTCGACTTCCAGTTTTCTTGGTACTCAGGGCGGCCCTGAGGTCTGGGAGAAGCGGAGGGGTTTTGGGGTGCCGGAGAGGCCGCTGTAAAGGGAAACGGTGGTGTTTCTCAGGAGGGAACTCGGGACCGCAGAAGCTGCTGCGCCTCTGGGAGCCTGGGTGGGCCTGGGCCGGGAGCCCGGGAGCTGCTCCCGACCCCACGCAGGCCCGCGCTGGGGCAGCCGCTTCGGCGCCCCCTCCCCGGGCCCAGTCTCATCACGCGGAACCGCTGCCCCGCGCCCGGGTGCGGGCGGGAGGTGGAGCCAGTTCAGAGGAGGGGACCCTTTACGGTAAAAGCTGCCGTCCCTTGTGGCTTCTAGAAGATAGGAAAACAAGTGGCTCCGAGAGGCGCTTCTGACACACAGCACAGCGGCGGGTAGAGCTGGATCCTAATTGCAGGTGCCCTGTGCTGCCCTGTTCTGGACAGGCACAAAGACCACGACTTTGTGGGGGCCGGGAGAGGGTAGAGGAGGAGGTGGCAGGCTTGGTGAAAGAGGGCCTTTGTCCAGTGCTCTCCTGCCCTGCCCCCCACCAGCCCTTCTGTGGGACCATTGTACCCGCATGCCAGACAAGAGAGTATTATCTGTTGCGGCCATTGTTGGGGGAAGGGAGGCAGTCTTGGGGTAACCCTTCTCCACTCCCCCCCTTCTCTGTGCACTCAGCCGTGGCAGCTGTGGCTTGGCCCAGACACAGAGACCCCCACCTCCAAAGAGGACGTCCTTAGTAGGTGCCAAGCATATAAGAGTGAGGCCAGTCCCAGAACCGCAGGCTCCTGGCGCGCCCCGCATGCCTCCAGCACGTTTACCTTTCCGAAGTGGCAGGAATGGGGAAAGCGCACGCTTAGGAGAGCTTCAGACAAGCTTCCCTCTTCCTCCTCCACGACCAGAAGCGGAAAGGTGCTCCCGGACCGAAAGGGAAAGAAGGTCCAGCACTGCCCCGCTTGGGAAGGCACCCACAACCAGTCTAGGGACTAGGGGTAAGGCCGGCGGGGAGCCCGCGAATGACCTGGGCTGACATCTCTTCCCCTCCTTACACAGAACAGAGGCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCACGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAGGACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCACGGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCGAGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACACCAACCACGAACGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAGAAGGAGCTGCGACAATGTAGGTGGCAGGTTGGGGCCTTATAAGCCCACCTTGCTGGGCACAGGGTGCTGCGGGCAAAGGACCATCATTGTACTCAAAGGATGGAGCACGAAGCAGCAGGAGGCAGAGAGAGGCTCACCTCAGCGGGGGCAGGGGCAAGCGGTGCGTCCCAGTGGTAGCCTTGGGGAGTTGGCAGCACATTGGGAACACGGGGGCTTCCCAGAGCGCCTTTCCTCCCACCACACCTATCCTTCTAGCCCTCTTCTCTCCGACACCCTTTTCCCAGCCTGAATGTAGACCACTGTCCCTTGTCTTGGAGGTGGGAAAAACAAATTACTGTAGTAACAGGAAACATGTCCTCTTCTAATGTAACCTTAGAGGGGGAATCAAGCCCAGTGTTTTCCAACGCATTTTTAGCAGCAGAATCATGTTCCAAAAAATAATAATAATAATCACATGAAATTGTAAGCTGCAAAAAAATTAAAACTAGGACTATTGTGGCTTCACTGGGGATGGTTCTCAGGCCTCGGACTGCTCAATTTACTCATGGGTTTGTGGCATCTGCAGCTCCAGAGGACACAAGTCTCACACTTAGGCCAAAACCCGTTTTCAGATGGAAAAACATGGACCCAGGAGGGATGTGGGGTTTACGGGCTGGAACCCTGGACTCTGGCCACTCTAGCAGGGTTCTCTCTTGGCATGGGCTTTTTGCTCCAATGATAGGTTTGAGATAAAGAAGGGTCCTGGTGGCTCTCCTGGAGTGACCTGTTGGAGAAGTGCCACCCACTAATCCATCTATATGCCTTTAGGCCATTTCTGGTTGCCTCCAATTTTATTTATTTATTTATTGTGACACGGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCTATCTCAGCTCAGTGCAACCTCTGCCTCCCAGATTCAAGCAATTCTCCTGCCTCAGCCTCTCGAGTAGCTAGGACTACAGGTGTGCACCACCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACAATGTTGGCCAGGCTGGTATTGAACTCCTGACCTCAGGTGATCCGCTTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACCGCACCCAGCCACCCCCAATTTTAGATGATCTTCATGCCTGAAATAGCCCCACTCTGGTTTGTTGACATTGTGTATATTGCACAGAAGCAGGGAATTTGTGCCTGTATGGGTTCTCAGAGAGCTTTTTTCTCAGCTCCTAAACTTGAACTCTGCAGTGAACTGTGGTGCTTGCAGTGACATTGGCCAGGAGCAAGCCCTGTACCTGTGAGCTGGTGGCTCTGCCCTGGAGTGACTACTGCTCAAAGTTGCTTTTAATATTTATTTATGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTC
Task1_train_24346
A variant on Chromosome 17 in gene CNP (2'',3''-cyclic nucleotide 3'' phosphodiesterase) has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?
Pathogenic; Myopia 2, autosomal dominant
TGAACAATGGGATACCTGCCTCAGGGGTTGCTGCGAGGACTGAGTGCTTAGCACAGCACTTGGACAGGAAACTCAAAAATCCAACGGAGCTCTCAGTGGTTTCACAGAGGAGGTGGCAGCTGAGGATCTGGCCTCAGAGGATGTTAGGATTTCACTCCGTTACTCATCTGTCCCTTTGGCCATTGCCATCCTGGTCTGTCTCCACAGCTCCTAGAAGGAAAGGTCGGGGCTGAGACTGACTTTCGGCTGGCACAGGGCCTGGACGAATGAGGCCAGTGAGGCATTTCAGATGCAGAGTTTACCGGAATGCCAGCAAATTGCATGATAATATTTTAATCCAATGTGGTAAAAAAAAAAGTTTTTAATTAATGCAAAAGTCCATGATGAATAAAATATCAAAAATTAAAGACAGGATCCGACTTTGCACGACCCTGCCTCACTCACTTCCTGCTAATCCACGGGACCGGGGAGGGTGACTGAGTTACCCCTCAACACGCAGAAAAAGCTAGTGGCCGCTCAGCTCGCAGGCGCAGTGGGTGGGTGCGCGTGGGGAGCAGGCGCGCGCAGGGGGCGGGACCGGGCCGAGGTTCCCGCGCGCGGCGAGAGTTTCGGGTTTTGGTTCGCAGCGCCTGCGCGCAGAGGAGACGGCCCGCCCCCAGCCCGCCCGGGTGCCCGCTCCGCCCCCCGGGCTATGTAAAGCGGCCGGGCTCGGGTCGTGCCACCGCTGGACTCCCGTGTCCCTCCGCGCAGGCGGGCGGCCCCGGAGCGCTGGTGCCGGCAGAGGCGGCGACGGTGGCGCCCCTCCTCATCATGGTGAGAGGCCGGGCGGGGCCGGGCACGGGGTAGCACCAGGGCGGGAAACGAGTGTCGGGGCCCCTCGGGAGGAAGCGTCTTGCAAACGAGGACCCGGGGCTCCGGGTTCGACTTCCAGTTTTCTTGGTACTCAGGGCGGCCCTGAGGTCTGGGAGAAGCGGAGGGGTTTTGGGGTGCCGGAGAGGCCGCTGTAAAGGGAAACGGTGGTGTTTCTCAGGAGGGAACTCGGGACCGCAGAAGCTGCTGCGCCTCTGGGAGCCTGGGTGGGCCTGGGCCGGGAGCCCGGGAGCTGCTCCCGACCCCACGCAGGCCCGCGCTGGGGCAGCCGCTTCGGCGCCCCCTCCCCGGGCCCAGTCTCATCACGCGGAACCGCTGCCCCGCGCCCGGGTGCGGGCGGGAGGTGGAGCCAGTTCAGAGGAGGGGACCCTTTACGGTAAAAGCTGCCGTCCCTTGTGGCTTCTAGAAGATAGGAAAACAAGTGGCTCCGAGAGGCGCTTCTGACACACAGCACAGCGGCGGGTAGAGCTGGATCCTAATTGCAGGTGCCCTGTGCTGCCCTGTTCTGGACAGGCACAAAGACCACGACTTTGTGGGGGCCGGGAGAGGGTAGAGGAGGAGGTGGCAGGCTTGGTGAAAGAGGGCCTTTGTCCAGTGCTCTCCTGCCCTGCCCCCCACCAGCCCTTCTGTGGGACCATTGTACCCGCATGCCAGACAAGAGAGTATTATCTGTTGCGGCCATTGTTGGGGGAAGGGAGGCAGTCTTGGGGTAACCCTTCTCCACTCCCCCCCTTCTCTGTGCACTCAGCCGTGGCAGCTGTGGCTTGGCCCAGACACAGAGACCCCCACCTCCAAAGAGGACGTCCTTAGTAGGTGCCAAGCATATAAGAGTGAGGCCAGTCCCAGAACCGCAGGCTCCTGGCGCGCCCCGCATGCCTCCAGCACGTTTACCTTTCCGAAGTGGCAGGAATGGGGAAAGCGCACGCTTAGGAGAGCTTCAGACAAGCTTCCCTCTTCCTCCTCCACGACCAGAAGCGGAAAGGTGCTCCCGGACCGAAAGGGAAAGAAGGTCCAGCACTGCCCCGCTTGGGAAGGCACCCACAACCAGTCTAGGGACTAGGGGTAAGGCCGGCGGGGAGCCCGCGAATGACCTGGGCTGACATCTCTTCCCCTCCTTACACAGAACAGAGGCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAAGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAGGACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCACGGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCGAGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACACCAACCACGAACGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAGAAGGAGCTGCGACAATGTAGGTGGCAGGTTGGGGCCTTATAAGCCCACCTTGCTGGGCACAGGGTGCTGCGGGCAAAGGACCATCATTGTACTCAAAGGATGGAGCACGAAGCAGCAGGAGGCAGAGAGAGGCTCACCTCAGCGGGGGCAGGGGCAAGCGGTGCGTCCCAGTGGTAGCCTTGGGGAGTTGGCAGCACATTGGGAACACGGGGGCTTCCCAGAGCGCCTTTCCTCCCACCACACCTATCCTTCTAGCCCTCTTCTCTCCGACACCCTTTTCCCAGCCTGAATGTAGACCACTGTCCCTTGTCTTGGAGGTGGGAAAAACAAATTACTGTAGTAACAGGAAACATGTCCTCTTCTAATGTAACCTTAGAGGGGGAATCAAGCCCAGTGTTTTCCAACGCATTTTTAGCAGCAGAATCATGTTCCAAAAAATAATAATAATAATCACATGAAATTGTAAGCTGCAAAAAAATTAAAACTAGGACTATTGTGGCTTCACTGGGGATGGTTCTCAGGCCTCGGACTGCTCAATTTACTCATGGGTTTGTGGCATCTGCAGCTCCAGAGGACACAAGTCTCACACTTAGGCCAAAACCCGTTTTCAGATGGAAAAACATGGACCCAGGAGGGATGTGGGGTTTACGGGCTGGAACCCTGGACTCTGGCCACTCTAGCAGGGTTCTCTCTTGGCATGGGCTTTTTGCTCCAATGATAGGTTTGAGATAAAGAAGGGTCCTGGTGGCTCTCCTGGAGTGACCTGTTGGAGAAGTGCCACCCACTAATCCATCTATATGCCTTTAGGCCATTTCTGGTTGCCTCCAATTTTATTTATTTATTTATTGTGACACGGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCTATCTCAGCTCAGTGCAACCTCTGCCTCCCAGATTCAAGCAATTCTCCTGCCTCAGCCTCTCGAGTAGCTAGGACTACAGGTGTGCACCACCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACAATGTTGGCCAGGCTGGTATTGAACTCCTGACCTCAGGTGATCCGCTTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACCGCACCCAGCCACCCCCAATTTTAGATGATCTTCATGCCTGAAATAGCCCCACTCTGGTTTGTTGACATTGTGTATATTGCACAGAAGCAGGGAATTTGTGCCTGTATGGGTTCTCAGAGAGCTTTTTTCTCAGCTCCTAAACTTGAACTCTGCAGTGAACTGTGGTGCTTGCAGTGACATTGGCCAGGAGCAAGCCCTGTACCTGTGAGCTGGTGGCTCTGCCCTGGAGTGACTACTGCTCAAAGTTGCTTTTAATATTTATTTATGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTC
TGAACAATGGGATACCTGCCTCAGGGGTTGCTGCGAGGACTGAGTGCTTAGCACAGCACTTGGACAGGAAACTCAAAAATCCAACGGAGCTCTCAGTGGTTTCACAGAGGAGGTGGCAGCTGAGGATCTGGCCTCAGAGGATGTTAGGATTTCACTCCGTTACTCATCTGTCCCTTTGGCCATTGCCATCCTGGTCTGTCTCCACAGCTCCTAGAAGGAAAGGTCGGGGCTGAGACTGACTTTCGGCTGGCACAGGGCCTGGACGAATGAGGCCAGTGAGGCATTTCAGATGCAGAGTTTACCGGAATGCCAGCAAATTGCATGATAATATTTTAATCCAATGTGGTAAAAAAAAAAGTTTTTAATTAATGCAAAAGTCCATGATGAATAAAATATCAAAAATTAAAGACAGGATCCGACTTTGCACGACCCTGCCTCACTCACTTCCTGCTAATCCACGGGACCGGGGAGGGTGACTGAGTTACCCCTCAACACGCAGAAAAAGCTAGTGGCCGCTCAGCTCGCAGGCGCAGTGGGTGGGTGCGCGTGGGGAGCAGGCGCGCGCAGGGGGCGGGACCGGGCCGAGGTTCCCGCGCGCGGCGAGAGTTTCGGGTTTTGGTTCGCAGCGCCTGCGCGCAGAGGAGACGGCCCGCCCCCAGCCCGCCCGGGTGCCCGCTCCGCCCCCCGGGCTATGTAAAGCGGCCGGGCTCGGGTCGTGCCACCGCTGGACTCCCGTGTCCCTCCGCGCAGGCGGGCGGCCCCGGAGCGCTGGTGCCGGCAGAGGCGGCGACGGTGGCGCCCCTCCTCATCATGGTGAGAGGCCGGGCGGGGCCGGGCACGGGGTAGCACCAGGGCGGGAAACGAGTGTCGGGGCCCCTCGGGAGGAAGCGTCTTGCAAACGAGGACCCGGGGCTCCGGGTTCGACTTCCAGTTTTCTTGGTACTCAGGGCGGCCCTGAGGTCTGGGAGAAGCGGAGGGGTTTTGGGGTGCCGGAGAGGCCGCTGTAAAGGGAAACGGTGGTGTTTCTCAGGAGGGAACTCGGGACCGCAGAAGCTGCTGCGCCTCTGGGAGCCTGGGTGGGCCTGGGCCGGGAGCCCGGGAGCTGCTCCCGACCCCACGCAGGCCCGCGCTGGGGCAGCCGCTTCGGCGCCCCCTCCCCGGGCCCAGTCTCATCACGCGGAACCGCTGCCCCGCGCCCGGGTGCGGGCGGGAGGTGGAGCCAGTTCAGAGGAGGGGACCCTTTACGGTAAAAGCTGCCGTCCCTTGTGGCTTCTAGAAGATAGGAAAACAAGTGGCTCCGAGAGGCGCTTCTGACACACAGCACAGCGGCGGGTAGAGCTGGATCCTAATTGCAGGTGCCCTGTGCTGCCCTGTTCTGGACAGGCACAAAGACCACGACTTTGTGGGGGCCGGGAGAGGGTAGAGGAGGAGGTGGCAGGCTTGGTGAAAGAGGGCCTTTGTCCAGTGCTCTCCTGCCCTGCCCCCCACCAGCCCTTCTGTGGGACCATTGTACCCGCATGCCAGACAAGAGAGTATTATCTGTTGCGGCCATTGTTGGGGGAAGGGAGGCAGTCTTGGGGTAACCCTTCTCCACTCCCCCCCTTCTCTGTGCACTCAGCCGTGGCAGCTGTGGCTTGGCCCAGACACAGAGACCCCCACCTCCAAAGAGGACGTCCTTAGTAGGTGCCAAGCATATAAGAGTGAGGCCAGTCCCAGAACCGCAGGCTCCTGGCGCGCCCCGCATGCCTCCAGCACGTTTACCTTTCCGAAGTGGCAGGAATGGGGAAAGCGCACGCTTAGGAGAGCTTCAGACAAGCTTCCCTCTTCCTCCTCCACGACCAGAAGCGGAAAGGTGCTCCCGGACCGAAAGGGAAAGAAGGTCCAGCACTGCCCCGCTTGGGAAGGCACCCACAACCAGTCTAGGGACTAGGGGTAAGGCCGGCGGGGAGCCCGCGAATGACCTGGGCTGACATCTCTTCCCCTCCTTACACAGAACAGAGGCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAGGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAGGACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCACGGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCGAGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACACCAACCACGAACGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAGAAGGAGCTGCGACAATGTAGGTGGCAGGTTGGGGCCTTATAAGCCCACCTTGCTGGGCACAGGGTGCTGCGGGCAAAGGACCATCATTGTACTCAAAGGATGGAGCACGAAGCAGCAGGAGGCAGAGAGAGGCTCACCTCAGCGGGGGCAGGGGCAAGCGGTGCGTCCCAGTGGTAGCCTTGGGGAGTTGGCAGCACATTGGGAACACGGGGGCTTCCCAGAGCGCCTTTCCTCCCACCACACCTATCCTTCTAGCCCTCTTCTCTCCGACACCCTTTTCCCAGCCTGAATGTAGACCACTGTCCCTTGTCTTGGAGGTGGGAAAAACAAATTACTGTAGTAACAGGAAACATGTCCTCTTCTAATGTAACCTTAGAGGGGGAATCAAGCCCAGTGTTTTCCAACGCATTTTTAGCAGCAGAATCATGTTCCAAAAAATAATAATAATAATCACATGAAATTGTAAGCTGCAAAAAAATTAAAACTAGGACTATTGTGGCTTCACTGGGGATGGTTCTCAGGCCTCGGACTGCTCAATTTACTCATGGGTTTGTGGCATCTGCAGCTCCAGAGGACACAAGTCTCACACTTAGGCCAAAACCCGTTTTCAGATGGAAAAACATGGACCCAGGAGGGATGTGGGGTTTACGGGCTGGAACCCTGGACTCTGGCCACTCTAGCAGGGTTCTCTCTTGGCATGGGCTTTTTGCTCCAATGATAGGTTTGAGATAAAGAAGGGTCCTGGTGGCTCTCCTGGAGTGACCTGTTGGAGAAGTGCCACCCACTAATCCATCTATATGCCTTTAGGCCATTTCTGGTTGCCTCCAATTTTATTTATTTATTTATTGTGACACGGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCTATCTCAGCTCAGTGCAACCTCTGCCTCCCAGATTCAAGCAATTCTCCTGCCTCAGCCTCTCGAGTAGCTAGGACTACAGGTGTGCACCACCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACAATGTTGGCCAGGCTGGTATTGAACTCCTGACCTCAGGTGATCCGCTTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACCGCACCCAGCCACCCCCAATTTTAGATGATCTTCATGCCTGAAATAGCCCCACTCTGGTTTGTTGACATTGTGTATATTGCACAGAAGCAGGGAATTTGTGCCTGTATGGGTTCTCAGAGAGCTTTTTTCTCAGCTCCTAAACTTGAACTCTGCAGTGAACTGTGGTGCTTGCAGTGACATTGGCCAGGAGCAAGCCCTGTACCTGTGAGCTGGTGGCTCTGCCCTGGAGTGACTACTGCTCAAAGTTGCTTTTAATATTTATTTATGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTC
Task1_train_24347
Consider this mutation in CNP (2'',3''-cyclic nucleotide 3'' phosphodiesterase) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; Leukodystrophy, hypomyelinating, 20
CATCCTGGTCTGTCTCCACAGCTCCTAGAAGGAAAGGTCGGGGCTGAGACTGACTTTCGGCTGGCACAGGGCCTGGACGAATGAGGCCAGTGAGGCATTTCAGATGCAGAGTTTACCGGAATGCCAGCAAATTGCATGATAATATTTTAATCCAATGTGGTAAAAAAAAAAGTTTTTAATTAATGCAAAAGTCCATGATGAATAAAATATCAAAAATTAAAGACAGGATCCGACTTTGCACGACCCTGCCTCACTCACTTCCTGCTAATCCACGGGACCGGGGAGGGTGACTGAGTTACCCCTCAACACGCAGAAAAAGCTAGTGGCCGCTCAGCTCGCAGGCGCAGTGGGTGGGTGCGCGTGGGGAGCAGGCGCGCGCAGGGGGCGGGACCGGGCCGAGGTTCCCGCGCGCGGCGAGAGTTTCGGGTTTTGGTTCGCAGCGCCTGCGCGCAGAGGAGACGGCCCGCCCCCAGCCCGCCCGGGTGCCCGCTCCGCCCCCCGGGCTATGTAAAGCGGCCGGGCTCGGGTCGTGCCACCGCTGGACTCCCGTGTCCCTCCGCGCAGGCGGGCGGCCCCGGAGCGCTGGTGCCGGCAGAGGCGGCGACGGTGGCGCCCCTCCTCATCATGGTGAGAGGCCGGGCGGGGCCGGGCACGGGGTAGCACCAGGGCGGGAAACGAGTGTCGGGGCCCCTCGGGAGGAAGCGTCTTGCAAACGAGGACCCGGGGCTCCGGGTTCGACTTCCAGTTTTCTTGGTACTCAGGGCGGCCCTGAGGTCTGGGAGAAGCGGAGGGGTTTTGGGGTGCCGGAGAGGCCGCTGTAAAGGGAAACGGTGGTGTTTCTCAGGAGGGAACTCGGGACCGCAGAAGCTGCTGCGCCTCTGGGAGCCTGGGTGGGCCTGGGCCGGGAGCCCGGGAGCTGCTCCCGACCCCACGCAGGCCCGCGCTGGGGCAGCCGCTTCGGCGCCCCCTCCCCGGGCCCAGTCTCATCACGCGGAACCGCTGCCCCGCGCCCGGGTGCGGGCGGGAGGTGGAGCCAGTTCAGAGGAGGGGACCCTTTACGGTAAAAGCTGCCGTCCCTTGTGGCTTCTAGAAGATAGGAAAACAAGTGGCTCCGAGAGGCGCTTCTGACACACAGCACAGCGGCGGGTAGAGCTGGATCCTAATTGCAGGTGCCCTGTGCTGCCCTGTTCTGGACAGGCACAAAGACCACGACTTTGTGGGGGCCGGGAGAGGGTAGAGGAGGAGGTGGCAGGCTTGGTGAAAGAGGGCCTTTGTCCAGTGCTCTCCTGCCCTGCCCCCCACCAGCCCTTCTGTGGGACCATTGTACCCGCATGCCAGACAAGAGAGTATTATCTGTTGCGGCCATTGTTGGGGGAAGGGAGGCAGTCTTGGGGTAACCCTTCTCCACTCCCCCCCTTCTCTGTGCACTCAGCCGTGGCAGCTGTGGCTTGGCCCAGACACAGAGACCCCCACCTCCAAAGAGGACGTCCTTAGTAGGTGCCAAGCATATAAGAGTGAGGCCAGTCCCAGAACCGCAGGCTCCTGGCGCGCCCCGCATGCCTCCAGCACGTTTACCTTTCCGAAGTGGCAGGAATGGGGAAAGCGCACGCTTAGGAGAGCTTCAGACAAGCTTCCCTCTTCCTCCTCCACGACCAGAAGCGGAAAGGTGCTCCCGGACCGAAAGGGAAAGAAGGTCCAGCACTGCCCCGCTTGGGAAGGCACCCACAACCAGTCTAGGGACTAGGGGTAAGGCCGGCGGGGAGCCCGCGAATGACCTGGGCTGACATCTCTTCCCCTCCTTACACAGAACAGAGGCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAAGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAGGACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCACGGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTCGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCGAGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACACCAACCACGAACGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAGAAGGAGCTGCGACAATGTAGGTGGCAGGTTGGGGCCTTATAAGCCCACCTTGCTGGGCACAGGGTGCTGCGGGCAAAGGACCATCATTGTACTCAAAGGATGGAGCACGAAGCAGCAGGAGGCAGAGAGAGGCTCACCTCAGCGGGGGCAGGGGCAAGCGGTGCGTCCCAGTGGTAGCCTTGGGGAGTTGGCAGCACATTGGGAACACGGGGGCTTCCCAGAGCGCCTTTCCTCCCACCACACCTATCCTTCTAGCCCTCTTCTCTCCGACACCCTTTTCCCAGCCTGAATGTAGACCACTGTCCCTTGTCTTGGAGGTGGGAAAAACAAATTACTGTAGTAACAGGAAACATGTCCTCTTCTAATGTAACCTTAGAGGGGGAATCAAGCCCAGTGTTTTCCAACGCATTTTTAGCAGCAGAATCATGTTCCAAAAAATAATAATAATAATCACATGAAATTGTAAGCTGCAAAAAAATTAAAACTAGGACTATTGTGGCTTCACTGGGGATGGTTCTCAGGCCTCGGACTGCTCAATTTACTCATGGGTTTGTGGCATCTGCAGCTCCAGAGGACACAAGTCTCACACTTAGGCCAAAACCCGTTTTCAGATGGAAAAACATGGACCCAGGAGGGATGTGGGGTTTACGGGCTGGAACCCTGGACTCTGGCCACTCTAGCAGGGTTCTCTCTTGGCATGGGCTTTTTGCTCCAATGATAGGTTTGAGATAAAGAAGGGTCCTGGTGGCTCTCCTGGAGTGACCTGTTGGAGAAGTGCCACCCACTAATCCATCTATATGCCTTTAGGCCATTTCTGGTTGCCTCCAATTTTATTTATTTATTTATTGTGACACGGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCTATCTCAGCTCAGTGCAACCTCTGCCTCCCAGATTCAAGCAATTCTCCTGCCTCAGCCTCTCGAGTAGCTAGGACTACAGGTGTGCACCACCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACAATGTTGGCCAGGCTGGTATTGAACTCCTGACCTCAGGTGATCCGCTTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACCGCACCCAGCCACCCCCAATTTTAGATGATCTTCATGCCTGAAATAGCCCCACTCTGGTTTGTTGACATTGTGTATATTGCACAGAAGCAGGGAATTTGTGCCTGTATGGGTTCTCAGAGAGCTTTTTTCTCAGCTCCTAAACTTGAACTCTGCAGTGAACTGTGGTGCTTGCAGTGACATTGGCCAGGAGCAAGCCCTGTACCTGTGAGCTGGTGGCTCTGCCCTGGAGTGACTACTGCTCAAAGTTGCTTTTAATATTTATTTATGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCCAATTCTCTGCCTCAGCTTCCCAAGTAGCTGGGAATACAGGCGCCTGCCACCATGCCCGGCTAATTTTTTTTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATCTTGACCAGGCTGGTCGGTAGCACAAAAGAAAGGAGGGGCCCTTGGCC
CATCCTGGTCTGTCTCCACAGCTCCTAGAAGGAAAGGTCGGGGCTGAGACTGACTTTCGGCTGGCACAGGGCCTGGACGAATGAGGCCAGTGAGGCATTTCAGATGCAGAGTTTACCGGAATGCCAGCAAATTGCATGATAATATTTTAATCCAATGTGGTAAAAAAAAAAGTTTTTAATTAATGCAAAAGTCCATGATGAATAAAATATCAAAAATTAAAGACAGGATCCGACTTTGCACGACCCTGCCTCACTCACTTCCTGCTAATCCACGGGACCGGGGAGGGTGACTGAGTTACCCCTCAACACGCAGAAAAAGCTAGTGGCCGCTCAGCTCGCAGGCGCAGTGGGTGGGTGCGCGTGGGGAGCAGGCGCGCGCAGGGGGCGGGACCGGGCCGAGGTTCCCGCGCGCGGCGAGAGTTTCGGGTTTTGGTTCGCAGCGCCTGCGCGCAGAGGAGACGGCCCGCCCCCAGCCCGCCCGGGTGCCCGCTCCGCCCCCCGGGCTATGTAAAGCGGCCGGGCTCGGGTCGTGCCACCGCTGGACTCCCGTGTCCCTCCGCGCAGGCGGGCGGCCCCGGAGCGCTGGTGCCGGCAGAGGCGGCGACGGTGGCGCCCCTCCTCATCATGGTGAGAGGCCGGGCGGGGCCGGGCACGGGGTAGCACCAGGGCGGGAAACGAGTGTCGGGGCCCCTCGGGAGGAAGCGTCTTGCAAACGAGGACCCGGGGCTCCGGGTTCGACTTCCAGTTTTCTTGGTACTCAGGGCGGCCCTGAGGTCTGGGAGAAGCGGAGGGGTTTTGGGGTGCCGGAGAGGCCGCTGTAAAGGGAAACGGTGGTGTTTCTCAGGAGGGAACTCGGGACCGCAGAAGCTGCTGCGCCTCTGGGAGCCTGGGTGGGCCTGGGCCGGGAGCCCGGGAGCTGCTCCCGACCCCACGCAGGCCCGCGCTGGGGCAGCCGCTTCGGCGCCCCCTCCCCGGGCCCAGTCTCATCACGCGGAACCGCTGCCCCGCGCCCGGGTGCGGGCGGGAGGTGGAGCCAGTTCAGAGGAGGGGACCCTTTACGGTAAAAGCTGCCGTCCCTTGTGGCTTCTAGAAGATAGGAAAACAAGTGGCTCCGAGAGGCGCTTCTGACACACAGCACAGCGGCGGGTAGAGCTGGATCCTAATTGCAGGTGCCCTGTGCTGCCCTGTTCTGGACAGGCACAAAGACCACGACTTTGTGGGGGCCGGGAGAGGGTAGAGGAGGAGGTGGCAGGCTTGGTGAAAGAGGGCCTTTGTCCAGTGCTCTCCTGCCCTGCCCCCCACCAGCCCTTCTGTGGGACCATTGTACCCGCATGCCAGACAAGAGAGTATTATCTGTTGCGGCCATTGTTGGGGGAAGGGAGGCAGTCTTGGGGTAACCCTTCTCCACTCCCCCCCTTCTCTGTGCACTCAGCCGTGGCAGCTGTGGCTTGGCCCAGACACAGAGACCCCCACCTCCAAAGAGGACGTCCTTAGTAGGTGCCAAGCATATAAGAGTGAGGCCAGTCCCAGAACCGCAGGCTCCTGGCGCGCCCCGCATGCCTCCAGCACGTTTACCTTTCCGAAGTGGCAGGAATGGGGAAAGCGCACGCTTAGGAGAGCTTCAGACAAGCTTCCCTCTTCCTCCTCCACGACCAGAAGCGGAAAGGTGCTCCCGGACCGAAAGGGAAAGAAGGTCCAGCACTGCCCCGCTTGGGAAGGCACCCACAACCAGTCTAGGGACTAGGGGTAAGGCCGGCGGGGAGCCCGCGAATGACCTGGGCTGACATCTCTTCCCCTCCTTACACAGAACAGAGGCTTCTCCCGAAAAAGCCACACATTCCTGCCCAAGATCTTCTTCCGCAAGATGTCATCCTCAGGGGCCAAGGACAAGCCTGAGCTGCAGTTTCCCTTCCTTCAGGATGAGGACACAGTGGCCACGCTGCTAGAGTGCAAGACGCTCTTCATCTTGCGCGGCCTGCCAGGAAGCGGCAAGTCCACGCTGGCACGGGTCATCGTGGACAAGTACCGTGATGGCACCAAGATGGTGTTGGCTGACGCTTACAAGATCACCCCCGGCGCTCGAGGAGCCTTCTCCGAGGAGTACAAGCGGCTCGATGAGGACCTGGCTGCCTACTGCCGCCGCCGGGACATCAGAATTCTTGTGCTTGATGACACCAACCACGAACGGGAACGGCTGGAGCAGCTCTTTGAAATGGCCGACCAGTACCAGTACCAGGTGGTGCTGGTGGAGCCCAAGACGGCGTGGCGGCTGGACTGTGCCCAGCTCAAGGAGAAGAACCAGTGGCAGCTGTCGGCTGATGACCTGAAGAAGCTGAAGCCTGGGCTGGAGAAGGACTTCCTGCCGCTCTACTTCGGCTGGTTCCTGACCAAGAAGAGCTCTGAGACCCTCCGCAAAGCCGGCCAGGTCTTCCTGGAAGAGCTGGGGAACCACAAGGCCTTCAAGAAGGAGCTGCGACAATGTAGGTGGCAGGTTGGGGCCTTATAAGCCCACCTTGCTGGGCACAGGGTGCTGCGGGCAAAGGACCATCATTGTACTCAAAGGATGGAGCACGAAGCAGCAGGAGGCAGAGAGAGGCTCACCTCAGCGGGGGCAGGGGCAAGCGGTGCGTCCCAGTGGTAGCCTTGGGGAGTTGGCAGCACATTGGGAACACGGGGGCTTCCCAGAGCGCCTTTCCTCCCACCACACCTATCCTTCTAGCCCTCTTCTCTCCGACACCCTTTTCCCAGCCTGAATGTAGACCACTGTCCCTTGTCTTGGAGGTGGGAAAAACAAATTACTGTAGTAACAGGAAACATGTCCTCTTCTAATGTAACCTTAGAGGGGGAATCAAGCCCAGTGTTTTCCAACGCATTTTTAGCAGCAGAATCATGTTCCAAAAAATAATAATAATAATCACATGAAATTGTAAGCTGCAAAAAAATTAAAACTAGGACTATTGTGGCTTCACTGGGGATGGTTCTCAGGCCTCGGACTGCTCAATTTACTCATGGGTTTGTGGCATCTGCAGCTCCAGAGGACACAAGTCTCACACTTAGGCCAAAACCCGTTTTCAGATGGAAAAACATGGACCCAGGAGGGATGTGGGGTTTACGGGCTGGAACCCTGGACTCTGGCCACTCTAGCAGGGTTCTCTCTTGGCATGGGCTTTTTGCTCCAATGATAGGTTTGAGATAAAGAAGGGTCCTGGTGGCTCTCCTGGAGTGACCTGTTGGAGAAGTGCCACCCACTAATCCATCTATATGCCTTTAGGCCATTTCTGGTTGCCTCCAATTTTATTTATTTATTTATTGTGACACGGAGTCTCCCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCTATCTCAGCTCAGTGCAACCTCTGCCTCCCAGATTCAAGCAATTCTCCTGCCTCAGCCTCTCGAGTAGCTAGGACTACAGGTGTGCACCACCACGTCCAGCTAATTTTTGTATTTTTAGTAGAGACGGAGTTTCACAATGTTGGCCAGGCTGGTATTGAACTCCTGACCTCAGGTGATCCGCTTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACCGCACCCAGCCACCCCCAATTTTAGATGATCTTCATGCCTGAAATAGCCCCACTCTGGTTTGTTGACATTGTGTATATTGCACAGAAGCAGGGAATTTGTGCCTGTATGGGTTCTCAGAGAGCTTTTTTCTCAGCTCCTAAACTTGAACTCTGCAGTGAACTGTGGTGCTTGCAGTGACATTGGCCAGGAGCAAGCCCTGTACCTGTGAGCTGGTGGCTCTGCCCTGGAGTGACTACTGCTCAAAGTTGCTTTTAATATTTATTTATGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCATGATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCCAATTCTCTGCCTCAGCTTCCCAAGTAGCTGGGAATACAGGCGCCTGCCACCATGCCCGGCTAATTTTTTTTTATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATCTTGACCAGGCTGGTCGGTAGCACAAAAGAAAGGAGGGGCCCTTGGCC
Task1_train_24348
Located on Chromosome 17, this mutation impacts CNP (2'',3''-cyclic nucleotide 3'' phosphodiesterase). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; Myopia 2, autosomal dominant
CACCTCGGCCTCCCAGAGTGCTGGGATTACAGGTGTGAACCACCGCACCTGGCCTGAGAATTTTAACTTTTTATTGCTCTAAAGTTGCCATTAGTTTGACCAACTAACCAATGAATGAGCTGTAGTGGGTTGCTGGAGAGGTGATGCTTAGTGTCCGAGTGTTTTGCGCTGGGCCTCGGTGGTCCTGGTGGCGGATGTTGGTATGCCCCTGCTCCCCTGCCCTGACTGCACCCGTTTTCTCCCGGCAGTCGTCCCTGGGGATGAGCCCAGGGAGAAGATGGACTTGGTCACCTACTTTGGAAAGAGACCCCCAGGCGTGCTGCATTGCACAACCAAGTTTTGTGACTACGGGAAGGCTCCCGGGGCAGAGGAGTACGCTCAACAAGATGTGAGTCTTCCCCAGGGACACATGGGGGAGGTGGGAGGTTGGGGGAGAAGGGGCTGCAGCATCTTCTGAAGATAGGTACCGGTGCCAGGCAGGGACCAAAAACCAGATGGCAGCTCAAGAAAAATGGCATCTCCTCCTCCTAGCTCCCCTGTCCCCAGGCGTAGCTGCATAGACCTCAGCCGCAGGTTCTAAGGAGCCTGCCCTGGCAGTACTGCCAGCCTGTGCATTCACCTGCCCCCAAGCACCTTCGCCTTCTGCAGATTCATGGAGAATGCTGGTCCACAGTGGGCTCCTGCTCTGGTCTCTCTGAGCCTGTTTTACCTTCCAAAGACTAGGAGTCCTTCGCCCCCAGGGAGCCTGGTGCACTGAGGTCCCCATCCCTGTCCCCAGGTCTGAGGTCTGGCCTGGCCCCAGAGTGAGGGAGTTTCATACGATAATGAAGCTTATTGGCTAATGGGTACGAGACCTTTCTGCACCACACAGCTGGCACCTTACACCCACAGCCACTGACAGTGATCCCTGAATGCCAGGCATGTCACCCATATCCACAGTCTCCAACTTCCAAGTGTCCACCCCCAAGCCCACTCTCCCACTTCTCTGCCTAGGTTAGCACAATCGTTTGTTTGTTCACTAGAGTGTCCTCCCAAATGGAAGCTCCCCTGAGGGCGAGTTTTTAAGTTTCGTTGACTCCTGTGGTTCCAGCACCCTAGCATAGTGGAATGAATATGTAACACCTGAGCTACCATCCCTAACCATGCCTTCATTTAGCATTTATTAACTACCCATTTCATGCCAGACACTGTTGGGACAAGGGATCGTGAGCAAAAATAGAAAAGCGTTTATGCTGAGATGGGATGGGCTGTCTCAAAGAATCAGATAGAAGCAGACATATCATCAGATGGGAACCAAAGTGTAAGAGCAGGTTTCCATCAAGGGCGAGTCTGACCTCAGTCTGACCTCACCCTGTCCTCCAGGGCGCTGTCTGGGTCCCAGGGGAAGCTGAGCGGTGCCAACAGTAGCAGCTGTTGTGTGCGCGGACACCCCTGTGGGCTGTTTACCTAGTCACTCTCATAACCACATTAACTCTGAGGTAGGCTCTGGTTCTCCCTGTTTTACGGGTGATGAAGCCAAGGCACCGAGAGGTCAGCCAGCCCGCTGAGGCCGGAAGCCAGTGTGCAGGGAGCTGGGCTCCCTCAGGAAGTCCGGCTGTCCCCGTGTGGCCCTGTCTGAGCGCCTTCGTGTTTCTCACTTGAGCCTGGAGCGCCTATGGAAGGTGCGTGCCGCAGTTGTTAGTGGATGCTGGGCCTATACCGACCCCTGCTCAGCTGTGCTCACTTCTGTTAGACTTCCCCTTCTCTCCTCCAGGAGGGACCCTCCCTGGGTCAGCTGTTCCTCAAGAGCCTGCCATCTCTAGCTTGGGCCCCTCTTTCTCACTCTCCCCAGGTGTTAAAGAAATCTTACTCCAAGGCCTTCACGCTGACCATCTCTGCCCTCTTTGTGACACCCAAGACGACTGGGGCCCGGGTGGAGTTAAGCGAGCAGCAACTGCAGTTGTGGCCGAGTGATGTGGACAAGCTGTCACCCACTGACAACCTGCCGCGGGGGAGCCGCGCCCACATCACCCTCGGCTGTGCAGCTGACGTAGAGGCCGTGCAGACGGGCCTTGACCTCTTAGAGATTCTGCGGCAGGAGAAGGGGGGCAGCCGAGGCGAGGAGGTGGGCGAGCTAAGCCGGGGCAAGCTCTATTCCTTGGGCAATGGGCGCTGGATGCTGACCCTGGCCAAGAACATGGAGGTCAGGGCCATCTTCACGGGGTACTACGGGAAAGGCAAACCTGTGCCCACGCAAGGTAGCCGGAAGGGGGGCGCCTTGCAGTCCTGCACCATCATATGAGTGTTCTCACCACCACTTATGCCCCTAGAAGGGAAGGGGAGAGGGAAACGTGCCCTCTGTTTGATCCTTGTTTTGTGACATTTTTTTTTTTTTTTTTTTTACTCAAAGTTAACCTACCTGTAACTTTTTAAAAACTTGTAAAATAACTGACCCTCCCTTCCTGTCCGCCCTCTTCCCCTCTAATGCTCACGCTCCCAACACAAGGTGGGCAGGGAGGCACCATTCAGGAACCTGGACCAAAGCTGACGAGGCTGGGCCAAGCCAGGGATGGGGCCACAGCCAGAACCCCGAGCCCTACTTCCAGGTTCTGGTTAGCTCAGCCCCAGCCCAGCCCAGCTGCTCTGCCCAGAGCTGGGTGAGTGGGGAGACACCTCAGAGCCCCGCAAAACCCACTGACCGGAGGCAAAAGGCAGTGGGGCTGGGGGTAGTTTTCCATGGTCACAGAGAACTAGTGGTGGCTCTGAGAAGGGGAGGACCTCTGGGCTTTGATTCCATCTCCTTGTCTTTTTTCTTTGTTTTTAGAGACAGGGTCCTGCTATTTCCCAAGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCGAACTCCTGGGCTCAAGCAATCCTCCTGAGTGATCCCATTTCTTAATCAGTGTAGCCCCAAGAAGGCTGGGGCTATTTACCAGGGTAGAAAAAGGAGCTTACCTCCCACCTTTGGTCCTAAGTCCCTGCCCCCTCCCCTTCACACCATAACTAGGTAACAGTTTGATAACTAGGGAAGAAAGCAGAACAGTTAAGCAGCCGCCACATCCCCGCTGGCTGGGGGCCTCACTCCAGGAAGGGGCTGGACTGGCTGTCCTTTCCAGTGGCCTGGCTCCGCTGTGTGGATGGGGAGATCGGGGCCAGAGGCAGAACCCTGGTGAGGAAGCTCCAGTCCTGCTCTCTACCCAGCCCATCTTGCCTCCATGGTGCCTCTGGAGGCCTCTGGGCCTCCTCTAACAGGGGCTGGTGGGCACCAAGAGCCAATGGAGTAGACCCCTGGCTGGTAAGGGCCAAGTCCCACCGGTTGCTTCTGGGAAGGGGTTTCTAACACTAGTCTGTGTGCTGTGGTTCCTGGGGTGCCCTCCACTGCCCTCTGTTCAGTAACAGGGCCTTGCTAATCGGGTTGTCACTCAACAAAAGTGCTTTGGATTTAAGTTACTATCCTGGCTTTGCCCAACCTCAGCAACCTGTAAGACTGATAATGAAATAAATCATGTTAATCCTAGCTGTGTGCAGTCTCTCTTACCCTTCTGTGCCCAGCTCAGTCTTCCCTAGGGCTGGGTGTATTAGGACTGGCTTTGTCCCACAGCTTGGGGCCATCGGTCCTGTCTCCCCTCTGCTGGCCGGGCACAGCTGTGGTGAGGTTGGGCAGCTGAACAGTGTTGGCTTTCATGAGGAGGCAGAAAGCAGAGGCTGGCCTCAGACTCATACAGAAGGTGGGGGTTGGCTGGGTACGAGGGATGTGGAGCACAAAAGCCTCTCATCCCCCATTAACCAGGGCACCAAGCCCACAGGTGTCCCCAGCCCACTGGATCAGAAAGAGTTCAGTAAGACCGGAAGCTCCTGGTATGGGTTTCTCCCAGTTCTCTAGGGAAGGCCACCTGCAGGTCACTGAAACTTCAAGCACCAGGGAAGATCTAACATTTGAGTCCCTTCCAGGCCATCAGAGGCCTAGTCAGCCACATGGGAAACTTCCAAGACCTGACTCAGGCATCATTCCACCATGGCTAAGGCACCAGCCGGGGAAGACTTGAAAGAAAGGGGCAGGAGCTCAGATGAAGAGAAATCCT
CACCTCGGCCTCCCAGAGTGCTGGGATTACAGGTGTGAACCACCGCACCTGGCCTGAGAATTTTAACTTTTTATTGCTCTAAAGTTGCCATTAGTTTGACCAACTAACCAATGAATGAGCTGTAGTGGGTTGCTGGAGAGGTGATGCTTAGTGTCCGAGTGTTTTGCGCTGGGCCTCGGTGGTCCTGGTGGCGGATGTTGGTATGCCCCTGCTCCCCTGCCCTGACTGCACCCGTTTTCTCCCGGCAGTCGTCCCTGGGGATGAGCCCAGGGAGAAGATGGACTTGGTCACCTACTTTGGAAAGAGACCCCCAGGCGTGCTGCATTGCACAACCAAGTTTTGTGACTACGGGAAGGCTCCCGGGGCAGAGGAGTACGCTCAACAAGATGTGAGTCTTCCCCAGGGACACATGGGGGAGGTGGGAGGTTGGGGGAGAAGGGGCTGCAGCATCTTCTGAAGATAGGTACCGGTGCCAGGCAGGGACCAAAAACCAGATGGCAGCTCAAGAAAAATGGCATCTCCTCCTCCTAGCTCCCCTGTCCCCAGGCGTAGCTGCATAGACCTCAGCCGCAGGTTCTAAGGAGCCTGCCCTGGCAGTACTGCCAGCCTGTGCATTCACCTGCCCCCAAGCACCTTCGCCTTCTGCAGATTCATGGAGAATGCTGGTCCACAGTGGGCTCCTGCTCTGGTCTCTCTGAGCCTGTTTTACCTTCCAAAGACTAGGAGTCCTTCGCCCCCAGGGAGCCTGGTGCACTGAGGTCCCCATCCCTGTCCCCAGGTCTGAGGTCTGGCCTGGCCCCAGAGTGAGGGAGTTTCATACGATAATGAAGCTTATTGGCTAATGGGTACGAGACCTTTCTGCACCACACAGCTGGCACCTTACACCCACAGCCACTGACAGTGATCCCTGAATGCCAGGCATGTCACCCATATCCACAGTCTCCAACTTCCAAGTGTCCACCCCCAAGCCCACTCTCCCACTTCTCTGCCTAGGTTAGCACAATCGTTTGTTTGTTCACTAGAGTGTCCTCCCAAATGGAAGCTCCCCTGAGGGCGAGTTTTTAAGTTTCGTTGACTCCTGTGGTTCCAGCACCCTAGCATAGTGGAATGAATATGTAACACCTGAGCTACCATCCCTAACCATGCCTTCATTTAGCATTTATTAACTACCCATTTCATGCCAGACACTGTTGGGACAAGGGATCGTGAGCAAAAATAGAAAAGCGTTTATGCTGAGATGGGATGGGCTGTCTCAAAGAATCAGATAGAAGCAGACATATCATCAGATGGGAACCAAAGTGTAAGAGCAGGTTTCCATCAAGGGCGAGTCTGACCTCAGTCTGACCTCACCCTGTCCTCCAGGGCGCTGTCTGGGTCCCAGGGGAAGCTGAGCGGTGCCAACAGTAGCAGCTGTTGTGTGCGCGGACACCCCTGTGGGCTGTTTACCTAGTCACTCTCATAACCACATTAACTCTGAGGTAGGCTCTGGTTCTCCCTGTTTTACGGGTGATGAAGCCAAGGCACCGAGAGGTCAGCCAGCCCGCTGAGGCCGGAAGCCAGTGTGCAGGGAGCTGGGCTCCCTCAGGAAGTCCGGCTGTCCCCGTGTGGCCCTGTCTGAGCGCCTTCGTGTTTCTCACTTGAGCCTGGAGCGCCTATGGAAGGTGCGTGCCGCAGTTGTTAGTGGATGCTGGGCCTATACCGACCCCTGCTCAGCTGTGCTCACTTCTGTTAGACTTCCCCTTCTCTCCTCCAGGAGGGACCCTCCCTGGGTCAGCTGTTCCTCAAGAGCCTGCCATCTCTAGCTTGGGCCCCTCTTTCTCACTCTCCCCAGGTGTTAAAGAAATCTTACTCCAAGGCCTTCACGCTGACCATCTCTGCCCTCTTTGTGACACCCAAGACGACTGGGGCCCGGGTGGAGTTAAGCGAGCAGCAACTGCAGTTGTGGCCGAGTGATGTGGACAAGCTGTCACCCACTGACAACCTGCCGCGGGGGAGCCGCGCCCACATCACCCTCGGCTGTGCAGCTGACGTAGAGGCCGTGCAGACGGACCTTGACCTCTTAGAGATTCTGCGGCAGGAGAAGGGGGGCAGCCGAGGCGAGGAGGTGGGCGAGCTAAGCCGGGGCAAGCTCTATTCCTTGGGCAATGGGCGCTGGATGCTGACCCTGGCCAAGAACATGGAGGTCAGGGCCATCTTCACGGGGTACTACGGGAAAGGCAAACCTGTGCCCACGCAAGGTAGCCGGAAGGGGGGCGCCTTGCAGTCCTGCACCATCATATGAGTGTTCTCACCACCACTTATGCCCCTAGAAGGGAAGGGGAGAGGGAAACGTGCCCTCTGTTTGATCCTTGTTTTGTGACATTTTTTTTTTTTTTTTTTTTACTCAAAGTTAACCTACCTGTAACTTTTTAAAAACTTGTAAAATAACTGACCCTCCCTTCCTGTCCGCCCTCTTCCCCTCTAATGCTCACGCTCCCAACACAAGGTGGGCAGGGAGGCACCATTCAGGAACCTGGACCAAAGCTGACGAGGCTGGGCCAAGCCAGGGATGGGGCCACAGCCAGAACCCCGAGCCCTACTTCCAGGTTCTGGTTAGCTCAGCCCCAGCCCAGCCCAGCTGCTCTGCCCAGAGCTGGGTGAGTGGGGAGACACCTCAGAGCCCCGCAAAACCCACTGACCGGAGGCAAAAGGCAGTGGGGCTGGGGGTAGTTTTCCATGGTCACAGAGAACTAGTGGTGGCTCTGAGAAGGGGAGGACCTCTGGGCTTTGATTCCATCTCCTTGTCTTTTTTCTTTGTTTTTAGAGACAGGGTCCTGCTATTTCCCAAGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCGAACTCCTGGGCTCAAGCAATCCTCCTGAGTGATCCCATTTCTTAATCAGTGTAGCCCCAAGAAGGCTGGGGCTATTTACCAGGGTAGAAAAAGGAGCTTACCTCCCACCTTTGGTCCTAAGTCCCTGCCCCCTCCCCTTCACACCATAACTAGGTAACAGTTTGATAACTAGGGAAGAAAGCAGAACAGTTAAGCAGCCGCCACATCCCCGCTGGCTGGGGGCCTCACTCCAGGAAGGGGCTGGACTGGCTGTCCTTTCCAGTGGCCTGGCTCCGCTGTGTGGATGGGGAGATCGGGGCCAGAGGCAGAACCCTGGTGAGGAAGCTCCAGTCCTGCTCTCTACCCAGCCCATCTTGCCTCCATGGTGCCTCTGGAGGCCTCTGGGCCTCCTCTAACAGGGGCTGGTGGGCACCAAGAGCCAATGGAGTAGACCCCTGGCTGGTAAGGGCCAAGTCCCACCGGTTGCTTCTGGGAAGGGGTTTCTAACACTAGTCTGTGTGCTGTGGTTCCTGGGGTGCCCTCCACTGCCCTCTGTTCAGTAACAGGGCCTTGCTAATCGGGTTGTCACTCAACAAAAGTGCTTTGGATTTAAGTTACTATCCTGGCTTTGCCCAACCTCAGCAACCTGTAAGACTGATAATGAAATAAATCATGTTAATCCTAGCTGTGTGCAGTCTCTCTTACCCTTCTGTGCCCAGCTCAGTCTTCCCTAGGGCTGGGTGTATTAGGACTGGCTTTGTCCCACAGCTTGGGGCCATCGGTCCTGTCTCCCCTCTGCTGGCCGGGCACAGCTGTGGTGAGGTTGGGCAGCTGAACAGTGTTGGCTTTCATGAGGAGGCAGAAAGCAGAGGCTGGCCTCAGACTCATACAGAAGGTGGGGGTTGGCTGGGTACGAGGGATGTGGAGCACAAAAGCCTCTCATCCCCCATTAACCAGGGCACCAAGCCCACAGGTGTCCCCAGCCCACTGGATCAGAAAGAGTTCAGTAAGACCGGAAGCTCCTGGTATGGGTTTCTCCCAGTTCTCTAGGGAAGGCCACCTGCAGGTCACTGAAACTTCAAGCACCAGGGAAGATCTAACATTTGAGTCCCTTCCAGGCCATCAGAGGCCTAGTCAGCCACATGGGAAACTTCCAAGACCTGACTCAGGCATCATTCCACCATGGCTAAGGCACCAGCCGGGGAAGACTTGAAAGAAAGGGGCAGGAGCTCAGATGAAGAGAAATCCT
Task1_train_24349
Here is a mutation in HCRT (hypocretin neuropeptide precursor) on Chromosome 17. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?
Pathogenic; Narcolepsy 1
CTCAGCCTCCTTAGTAGCTGGGATCACAGGCGTGCATTACAATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATGTTTGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACGGAGCCTAGCCTGTGTCTCTACTTTTGGATGTTATATTAGTTTCCTAGGACTGCCATAACAAAGTACCACAAAGTGAGTGGCTCAAACAACAGAAACCTATTGTCTCACAGTTCTGGATGCTAGAAGTCCAAGCAAGGTCAGGTGAAGAGCGTTGGTTCCTTCTGAAGGCTATGAGGGAGAATCTGTTGCATGCCTCTCCCCTATCTTCTGGGGGTGGGGGTGCTGGCAATTTTTGGTGTTCCTTGGCTTGTAGGAGCCAATCTCTACCTTCATGTTCACATGGGTTCTCCCTGTGTGTGTTTCTGTGTTCCAATTCCCTTTTTTATAAGGACGCCAGTCACAGTGGATTAGAGGCCCACCCTACTCTAGTATGACCTCATCTTAACTAATTGCATCTGGAAGGACCTTATTTCCAAATACAGCCACATTCTGAAGTGCCACGGGTACGGACTTCAACATATGGATTTTGGGAACACCAGTAACAGGTGTCTTTGGCTGGAGTTGCAGTAAAATCTTGTACTGCCCCTGCTTAAGAATGTCCCATGACTCTGTTACCTACAAGATAAAGTGCAAAGCCCGATGATTTGTGAGAGCCTTTGCGAGCTGTGCTGCACTGACTGTAACTGTGTCCCTTCCTGAGCCTCTCCACTCCCCACACCCTATACCCCATGATGCAGCCATTCTGGATGACTCATTGTTGAAGTTCAAATTCCCTGCCTTTTCAGCAGGATTGACTCCCACCCCTTCCTAGCTGGATTCTGCTGCTCTATGCAGCTTGCCTGCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTTCTTTCCTTTCTTTCTTTTCTTTTTTCTTTTTCTTTCTTTTTTTTTTTTTTTTGACAGTGCCTCCTTCTGTTGCCCAGGCTGGAGTGCAGTGGCCCAATTATGGCTCAAACTCAAACTCCTGGGCTCAAGCAATCCTCTCGCCCACCATACCCCGCTAATTAAAAAAACTTTTTGGAGAGATGTCTCACTCACTATGTTGCCTAGGCTCGTCTCGAACTCCTTGCTTCAAGGGATCCTCCTGCTTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCACCGCGCCCGACCGCTGCAACCTTTCTTGCTTTCCTTCCCCTTCCGCGTCTCTGGGTAAAGTCCCCGCTACAGAATGCCTAGCAGAGCATCGTAGGAGTCCCGCATGGCCCGATCCAAGCATGCACCTGTGCAGTTCTCTCTGTGCCCCAGGGCCTTGCACTGGGAACTCCCCAACCAAGAGTGTTTCCGATTCAACCACGCAAAAGCTAAGGCTGGTGCCCGACAGCCGGGCTTCCAGGCCCAGCTGTCCTCCGCAAGACGCTTTGCCACCCCGGATGGGCAGGACGCGACCGCACAGGAACAGAGACCAGTCACACGAATGGAGACTCGTCTTTATTGCCTTTTTTCTGGGGGCTGACGCTGGGTGGGCAGAGGGCAGAGGCCTGGGCCAGGACAGGGCCCGAAGAACGACTCAGATCCCGGACTGTCCTCCGGGCGCGACGGAGGCGGCGGCCGGGGCGGAACAGCGGCGCCCGAGGCAGGGGCGCGGCGCTGGCTCTGCGCCTGCGCGGCGGCCCATGGTCAGGATGCCCGCGGCGTGGTTGCCGCTGGCCTGCAGGAGGCGCTGCAGCCGACCCTGGAGGCCCGGGGGCCCGGACCTCCGCTTGCCCAGCGTGAGGATGCCGGCCGCGTGATTGCCCGCGCCGTGCAGCAGCTCGTAGAGGCGGCAAGAGCAAGTCTTTTGACGACAGCAGTCGGGCAGGGGCTGTGCAGCCGCCCCGGACGACAACAGCGCGGGCGGCAGCAGCAGCAGCAGCAGCAGTAGCGTCACGGCGGCCCAGGAGACCTAGGGAGACGGAGACAGGGCGCTGGGGGGGTCTTCCCACGGCGCCCGCCACCAGCTCCCACGCCCAGGACCTGCCCCTCTGGCTCCGCGCCCCCTCCAAGCCTGCACTCCTTTCTGGCTGTCACTTAGTTCTCCTTGCTTTGCGCCCTTGCTGGTATCGGCCTACTTTCCCTGCTCCTCCTTCAAGACCCAGCAGAGCATCTCCCCCAGGAAGCCTTTTGAGACCCCCTGGGCAGAGTGAATCCCCCTTTTCTCTGGAGACTTAGGCCACTGTGCCACCACTAGGGCACTTGCCACTCCACCTGAAAACAGGAGTGTCTGTCTGCAGCAGAAGTTGTAAACTTGGGAAAAACCCGGGCCCTACTGAGTCCCCCCAACTTCCTCTCCACAGCAGGGAAACACATGGAAATCAGGAACTAGCAAGACTCCAGAATGCTCTCTCATCTGCCTGCCCCCTTGCAGGAGTGACTGAACTCCGTTGCTTTGAACCAGTTTCCTGCCCTTTCAGAGGGCACAGCTCCCTTACCTGTAAACTGGGTATACTAGAAATAATTTCTACTCTGCAAGGCTGTTGGGAGGATGACAAGAGATGACAGGTGCAAACGGAGCACCTGACACATAGAGCTCAGCAAACACAGGCTCTTAGCAAAACAGCACCCAACCCAATGTGAGCCAAGGCAGGTGCTCCTGCCTCAGAGCACACCCAGGAAAAGACCAAGAGTGGAGACACCTTTGGCCTTTCTTCCAGCCCTCTGAGCAAGCACTCTTTTTGCTTCTCTGGGATGGTGAGTCACCCCTCCATCCCTGGATCTTTACCTTTGTGGAAGGAAGGTTCATGGTGTCTGGCGCTCAGGGTGGGGTAGCCGGGAAAGGAGATGTCTGTGGTGGTTCAAAAAGCCAGGAACCTTGAGGCTGTCAATTGTGACCCACTCCCAGGGGTCTGGGGTTTATAGTGCTCTGAGGTGGCGGGGAATTGACAGGCACTTGCGTCCACACCCAGGCCAGACAAAGGCAAGTCTAAGATTAGCCTGCTGCAGGGGGGCCGTCTCCAGGCTGGGCCCAAGGAATGGCCGCTGCGGCGTTCAGAGGCCAGGGTTGGATCACTGTGCCCCTGATCACCCCCTTGTCTGTCTATCTGCTCCCTGGAGATGGGGCGGTCTCCGGGCACTAATGAGGCCACCTTGCACCCAGGAATCTGGGAGCACAAAAGAGGCGCTGGCCTGGGACAATATGGAGGGAGGCAGCTGCTAATTAGGGGCGGGAGAGAGGCAGACGCGAGACCCCACATTATGTGTGTGGGGGGTGGAGCAGCCAGCAGCAGTCCTCTCCCTCCCCTGCTTCTTGTCGCTGCTCCTGGGGACTGTCAGGCTCCAGGACCTTCTTCCTTCATGGAAAGGCTCCTTAGCTGCCCCCTCCCCCTAGCTTTTTTTCTCCCTTCTGCCCTTTCCACTAGCCTCTGAGATGGAAAACCTTGAAAACTCAGCCTAGACAGTGGGAGGTAAGAAGCCAAAACCAAGCCCAATTTCTCTTTCTTTCTTTTCTGTGTGTGTGTGTGTGACTAAATTTTGGTCTTGTTGCTCAGGCTGGAGTGCAGTGGTATGGTCATCTTGGCTCACTGCAACCTCCGCCTTGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAATAGCTCCTGAATAGAATTACAGGCACACGCCACCACAACCAGCTAATTTTTGTATTTTTAATAGAGACAGGGTTTCACCATGTTAGCCAGGGTGGTCTCAAACTCCTGACCTCAAGTGATCCACCCACCTCAGTCTCCAAAAGTGTTGGGATTACAGGCGTGGGCCACTGCACCAGGCCCCCCCGCTTTTTTTTTCTTCCTTCCTTCTTTCCTTCTTCCTTCCTTCCTGCATTTCTTTCTTTCTTTCTCTCTCTCACTCTCTCCCTCTTTCTTTCTTTCTTCTTCTTCTTCTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCAATCT
CTCAGCCTCCTTAGTAGCTGGGATCACAGGCGTGCATTACAATGCCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCATGTTTGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACGGAGCCTAGCCTGTGTCTCTACTTTTGGATGTTATATTAGTTTCCTAGGACTGCCATAACAAAGTACCACAAAGTGAGTGGCTCAAACAACAGAAACCTATTGTCTCACAGTTCTGGATGCTAGAAGTCCAAGCAAGGTCAGGTGAAGAGCGTTGGTTCCTTCTGAAGGCTATGAGGGAGAATCTGTTGCATGCCTCTCCCCTATCTTCTGGGGGTGGGGGTGCTGGCAATTTTTGGTGTTCCTTGGCTTGTAGGAGCCAATCTCTACCTTCATGTTCACATGGGTTCTCCCTGTGTGTGTTTCTGTGTTCCAATTCCCTTTTTTATAAGGACGCCAGTCACAGTGGATTAGAGGCCCACCCTACTCTAGTATGACCTCATCTTAACTAATTGCATCTGGAAGGACCTTATTTCCAAATACAGCCACATTCTGAAGTGCCACGGGTACGGACTTCAACATATGGATTTTGGGAACACCAGTAACAGGTGTCTTTGGCTGGAGTTGCAGTAAAATCTTGTACTGCCCCTGCTTAAGAATGTCCCATGACTCTGTTACCTACAAGATAAAGTGCAAAGCCCGATGATTTGTGAGAGCCTTTGCGAGCTGTGCTGCACTGACTGTAACTGTGTCCCTTCCTGAGCCTCTCCACTCCCCACACCCTATACCCCATGATGCAGCCATTCTGGATGACTCATTGTTGAAGTTCAAATTCCCTGCCTTTTCAGCAGGATTGACTCCCACCCCTTCCTAGCTGGATTCTGCTGCTCTATGCAGCTTGCCTGCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTTCTTTCCTTTCTTTCTTTTCTTTTTTCTTTTTCTTTCTTTTTTTTTTTTTTTTGACAGTGCCTCCTTCTGTTGCCCAGGCTGGAGTGCAGTGGCCCAATTATGGCTCAAACTCAAACTCCTGGGCTCAAGCAATCCTCTCGCCCACCATACCCCGCTAATTAAAAAAACTTTTTGGAGAGATGTCTCACTCACTATGTTGCCTAGGCTCGTCTCGAACTCCTTGCTTCAAGGGATCCTCCTGCTTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCACCGCGCCCGACCGCTGCAACCTTTCTTGCTTTCCTTCCCCTTCCGCGTCTCTGGGTAAAGTCCCCGCTACAGAATGCCTAGCAGAGCATCGTAGGAGTCCCGCATGGCCCGATCCAAGCATGCACCTGTGCAGTTCTCTCTGTGCCCCAGGGCCTTGCACTGGGAACTCCCCAACCAAGAGTGTTTCCGATTCAACCACGCAAAAGCTAAGGCTGGTGCCCGACAGCCGGGCTTCCAGGCCCAGCTGTCCTCCGCAAGACGCTTTGCCACCCCGGATGGGCAGGACGCGACCGCACAGGAACAGAGACCAGTCACACGAATGGAGACTCGTCTTTATTGCCTTTTTTCTGGGGGCTGACGCTGGGTGGGCAGAGGGCAGAGGCCTGGGCCAGGACAGGGCCCGAAGAACGACTCAGATCCCGGACTGTCCTCCGGGCGCGACGGAGGCGGCGGCCGGGGCGGAACAGCGGCGCCCGAGGCAGGGGCGCGGCGCTGGCTCTGCGCCTGCGCGGCGGCCCATGGTCAGGATGCCCGCGGCGTGGTTGCCGCTGGCCTGCAGGAGGCGCTGCAGCCGACCCTGGAGGCCCGGGGGCCCGGACCTCCGCTTGCCCAGCGTGAGGATGCCGGCCGCGTGATTGCCCGCGCCGTGCAGCAGCTCGTAGAGGCGGCAAGAGCAAGTCTTTTGACGACAGCAGTCGGGCAGGGGCTGTGCAGCCGCCCCGGACGACAACAGCGCGGGCGGCAGCAGCAGCAGCAGCAGCCGTAGCGTCACGGCGGCCCAGGAGACCTAGGGAGACGGAGACAGGGCGCTGGGGGGGTCTTCCCACGGCGCCCGCCACCAGCTCCCACGCCCAGGACCTGCCCCTCTGGCTCCGCGCCCCCTCCAAGCCTGCACTCCTTTCTGGCTGTCACTTAGTTCTCCTTGCTTTGCGCCCTTGCTGGTATCGGCCTACTTTCCCTGCTCCTCCTTCAAGACCCAGCAGAGCATCTCCCCCAGGAAGCCTTTTGAGACCCCCTGGGCAGAGTGAATCCCCCTTTTCTCTGGAGACTTAGGCCACTGTGCCACCACTAGGGCACTTGCCACTCCACCTGAAAACAGGAGTGTCTGTCTGCAGCAGAAGTTGTAAACTTGGGAAAAACCCGGGCCCTACTGAGTCCCCCCAACTTCCTCTCCACAGCAGGGAAACACATGGAAATCAGGAACTAGCAAGACTCCAGAATGCTCTCTCATCTGCCTGCCCCCTTGCAGGAGTGACTGAACTCCGTTGCTTTGAACCAGTTTCCTGCCCTTTCAGAGGGCACAGCTCCCTTACCTGTAAACTGGGTATACTAGAAATAATTTCTACTCTGCAAGGCTGTTGGGAGGATGACAAGAGATGACAGGTGCAAACGGAGCACCTGACACATAGAGCTCAGCAAACACAGGCTCTTAGCAAAACAGCACCCAACCCAATGTGAGCCAAGGCAGGTGCTCCTGCCTCAGAGCACACCCAGGAAAAGACCAAGAGTGGAGACACCTTTGGCCTTTCTTCCAGCCCTCTGAGCAAGCACTCTTTTTGCTTCTCTGGGATGGTGAGTCACCCCTCCATCCCTGGATCTTTACCTTTGTGGAAGGAAGGTTCATGGTGTCTGGCGCTCAGGGTGGGGTAGCCGGGAAAGGAGATGTCTGTGGTGGTTCAAAAAGCCAGGAACCTTGAGGCTGTCAATTGTGACCCACTCCCAGGGGTCTGGGGTTTATAGTGCTCTGAGGTGGCGGGGAATTGACAGGCACTTGCGTCCACACCCAGGCCAGACAAAGGCAAGTCTAAGATTAGCCTGCTGCAGGGGGGCCGTCTCCAGGCTGGGCCCAAGGAATGGCCGCTGCGGCGTTCAGAGGCCAGGGTTGGATCACTGTGCCCCTGATCACCCCCTTGTCTGTCTATCTGCTCCCTGGAGATGGGGCGGTCTCCGGGCACTAATGAGGCCACCTTGCACCCAGGAATCTGGGAGCACAAAAGAGGCGCTGGCCTGGGACAATATGGAGGGAGGCAGCTGCTAATTAGGGGCGGGAGAGAGGCAGACGCGAGACCCCACATTATGTGTGTGGGGGGTGGAGCAGCCAGCAGCAGTCCTCTCCCTCCCCTGCTTCTTGTCGCTGCTCCTGGGGACTGTCAGGCTCCAGGACCTTCTTCCTTCATGGAAAGGCTCCTTAGCTGCCCCCTCCCCCTAGCTTTTTTTCTCCCTTCTGCCCTTTCCACTAGCCTCTGAGATGGAAAACCTTGAAAACTCAGCCTAGACAGTGGGAGGTAAGAAGCCAAAACCAAGCCCAATTTCTCTTTCTTTCTTTTCTGTGTGTGTGTGTGTGACTAAATTTTGGTCTTGTTGCTCAGGCTGGAGTGCAGTGGTATGGTCATCTTGGCTCACTGCAACCTCCGCCTTGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAATAGCTCCTGAATAGAATTACAGGCACACGCCACCACAACCAGCTAATTTTTGTATTTTTAATAGAGACAGGGTTTCACCATGTTAGCCAGGGTGGTCTCAAACTCCTGACCTCAAGTGATCCACCCACCTCAGTCTCCAAAAGTGTTGGGATTACAGGCGTGGGCCACTGCACCAGGCCCCCCCGCTTTTTTTTTCTTCCTTCCTTCTTTCCTTCTTCCTTCCTTCCTGCATTTCTTTCTTTCTTTCTCTCTCTCACTCTCTCCCTCTTTCTTTCTTTCTTCTTCTTCTTCTTTTTTTTTTTTTTGAGACGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCAATCT
Task1_train_24350
A change on Chromosome 17 affects gene STAT5B (signal transducer and activator of transcription 5B). Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.
Pathogenic; Growth hormone insensitivity with immune dysregulation 1, autosomal recessive
CTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCTGAAATAGTTTTAAAAGCCATGGGTAGGGGCCAGGCATGTTGGCTCATGCCTGTAATCCCACACTTTTGGAGGCCTAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCTAACATGATGAACCCTGTCTCTACTAAAAATACAAAAATCAGCCAAGTGTGGTGGCACTCATCCGTAGTCCCAGGTACTATGCTGAGGTAGGAGAATGGCTTGAAGCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATCATGACACTGCACTCCAGCCTGGGTGACAGAGACCCCATCTCAAAAATAAATAAATAAATAAATAAATAAAAATAAAAGCCATGGGTAGATAAGCAGGTAATACAAAAATCACTTCCCAAGAGATCCAATGATCTCAGACGTTTCAAGTTCAAACAGTATTCTAGCCCTCAGTAGAAGAAACAGTTTTTACTGGCCCCCAATCCCTGATTTCCCATACAAAGATATATAAAAGCTAGGAAGCATGCCCACAACCAGAGAAAGCATAAGAGCTATTAAAAGTGATGAATTTTTTTTTTTTCGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCCCACAACTACACCCGGCTAATTTTTTTGTGTTTTTAGTAGAGACGGGGGTTTCACTGTGATGGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCACCCAGCCTTTTTTTTTTTTTCTTTTAAGAGACAGGGTCTTACTCTGTTGCCCAGGCTGGAGTACAGTGATGTGATCATGACTCACTGTAACCTTGAACTCCCAGGGTCAAGTGATCATCCCACCTCACCCTCCAGAGTAGCTGGGACTACAGGCGCACACCATGAGCACCACCATGCCCACCTAATTAACTTATTTATTTATTTATTTACTTAGAGACAGGGTCTTACTATGTTGCCCAAGCTGGGCTTGAACTCCTGGCCTCAAGAGATCCTCCTGCCTGAGGCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGCCAAAAGTTATTAAAAACTTTAATTCACAGAAAATGAACCAGCAAGCTACCCTTATTGTGAGGGTCAGAGGAGAGAACTAACTTTCCTGATGCCCTGGTGCAGTGGCTCAAGCCCGTAATCCCAATACTTTGGGAAGCCAAAGTGGGGGATTGTTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACATACAAAAAATTTAAAAATTAGATGGGTGTGGTGGTGCACGTCTGTGGTCCCAGCTAATCGGGAGGCTAAGGGAGGAGGACTGCTTGAGGCCAGGAGGTCAAGGCTGCAGTGAGCCATGTTTGTGCCGCTGCACTCCAGCCCGGGCAAAAGAGTGAGACCCTGTTTCAAAAAAAGAAAAGAACTAACATCTTGGGTAGAAATGGTTGATGGCAATATCCATATGTTAATTAGGATAAAGGAATATTTTTACTACTGTAAGAACTCCAAATCATCAAATTCTTCACTGAAATAAGCTTTATGCAGAGTAGTACAATAAGGCAAACATTTTAAGAGGGAAGCAACTGAGATTCTGCACGGACTCTTGTATCATAGGTAGCCATGTCATGGTTAAATGTTCATGTGTAACCATGCTGCCATATACTTTCATGTATAACCAAATTAGCAATTGTGTTTCCCATAATAGTATTTTTCATAGGCTGCCTTATTATGAGTATGTCATGGCTATACATTTATGTTTCCCATAATTAGTACTGACCTCAACAAATAGTAAGTACCCACTAAATTATTTGTTAAAATAATTTTGTAACGAAAGCAGCTAACTTTGGACATAAGAAGGGAGGGGCACTCACGAGAATCAAACTTCCAAGCAATGGTGATGCCGCCAATTTCTGAGTCACTGAATCTCAGGAGGAAGGTCCCATCTGGCTTGTTAATGAGTAGGTCATGGGCCTGTTGCTTGTTTACAAACCCCAAAATGGCCCTGGATCACCAAGGACAAAGGACAGAAGCAGAGTGTGACTTACGATGCCAGAGAGAAGACCTTCAGACTCTGTCGGCGCCTTAAGAAATAATGATTCTCACCCATCATTCCAATGAGGCTTGAGATGTTTTTTTAACACTTCCATCACACCGTCAAACCATTGCCAGAAAGTGTAATTCCGTCCTGGTAAATTCTCCTGGTTGGAGATACAACAGTGAACATAAGAACACCAGAGTAACACTTGGAATATTATACACATATTTAATTGGAAAAATTAAATGGGAAACAAACATCTACCCTTGTCAGAGGCATACAAATATCCCCGCCTACCTGAGTTTTACCTAATGGCCCCATGGAGAGGAAAAGAGGGAAGAAGGGGAAAATACCAAACTGCAGTTACCAGCACCCAGTGGGCTCCTGCTACAGACACTTTCACCTGGGACTGGGCTGACCCGTCCCTTGCTAGTTTCGATGTGTGGTCTGTGACCAGAAGCATCAGTGTCACCTGGGAGCTTCTGAGAAATGCACGTTGTTAGGCTCCAAATTAAACATTTAAAACACCTTGGGGGTGGGGGGTGTAGGAAAAGAAACAAAAATTAAATTCAAATCAAGGTGATAGCCGGGCATGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCTGAGGTAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTGGCTGGACATGGTGGCGGGTGCCTGTAATCCCGGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAATCTGGGAGACGGAGGTTGCAGTGAGCCCAGAATGTACCACTGCACTCCTTGTGACAGAGCGAGACACCATCTCAAAAATAAATAAATAAACAAAAATAAATAGGGTGGGCACAGTGGACTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCCACTAAAAATACAAAATTGCGGGGCGTGGTGCCGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAAACCAGGAGGCGGCGGTTGCGGTGAGCCAAGATCGTGCCATTGCAGTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAAAAAAAAAATGAATAAAAATAAAATCAAAGTGACGTCTGAATTAGCAGATGCTAGAGGAGGAGTTTCTTTCATCAGCATCCCTCTTTGTGGGTTGAGGGTCCCATAGGAGCCTGATCTGGCATTACACATGGGGAACATAAGAGAGTAAAGGGGAGAGAGGCCCAGAGTTCGCATCCCCTCAAAAGCTTTGCTTCTCATGAGCTATGTTAACATCTGCTTTGCTCTATTTCCTTTACAAAGGAAGAAAATGCATTAACTGTAGACAAAGGTCAACTTATTTAAAATATGCAAAGATGTAATTTTCTACACGTGACCTGGGTAACTCTCAAGTTGTCCATCTAGTCAGAAGCTTCTATTACTTTCGGTACATTTTATTAGAGACATGAAGAATAAGGGCCCAGGGCAGGGAGACTCCTGAGAGCATCTGGTTGGGAAGGACTGATCTAACAGCGGCTGGCAGCTGGGCTCCTCACCCTGTTGAACTGGGACCAGGACACAGACAGGCCACTGTAGTCCTCCAGGTGGCTGCTGCTGTTGTTGAACAGTTTCTGCGCCAGGAACACGAGGTTCTCCTTGGTCAGGCCCCGGTTGCTCTGCACTTCGGCCTTGAATTTCATGTTGAGCGCCTCACACAGCTGTGGCCACAGCACTTTGTCAGGCACGGCAAATGGCACCCTGCCCTGAGAGGGAGAGAGGCCAGAATCTGATGAGAAAACAGTTGCATGA
CTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCTGAAATAGTTTTAAAAGCCATGGGTAGGGGCCAGGCATGTTGGCTCATGCCTGTAATCCCACACTTTTGGAGGCCTAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCTAACATGATGAACCCTGTCTCTACTAAAAATACAAAAATCAGCCAAGTGTGGTGGCACTCATCCGTAGTCCCAGGTACTATGCTGAGGTAGGAGAATGGCTTGAAGCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATCATGACACTGCACTCCAGCCTGGGTGACAGAGACCCCATCTCAAAAATAAATAAATAAATAAATAAATAAAAATAAAAGCCATGGGTAGATAAGCAGGTAATACAAAAATCACTTCCCAAGAGATCCAATGATCTCAGACGTTTCAAGTTCAAACAGTATTCTAGCCCTCAGTAGAAGAAACAGTTTTTACTGGCCCCCAATCCCTGATTTCCCATACAAAGATATATAAAAGCTAGGAAGCATGCCCACAACCAGAGAAAGCATAAGAGCTATTAAAAGTGATGAATTTTTTTTTTTTCGAGATGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGTGCCCACAACTACACCCGGCTAATTTTTTTGTGTTTTTAGTAGAGACGGGGGTTTCACTGTGATGGCCAGGATGGTCTCGATCTCCTGACCTCATGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCACCCAGCCTTTTTTTTTTTTTCTTTTAAGAGACAGGGTCTTACTCTGTTGCCCAGGCTGGAGTACAGTGATGTGATCATGACTCACTGTAACCTTGAACTCCCAGGGTCAAGTGATCATCCCACCTCACCCTCCAGAGTAGCTGGGACTACAGGCGCACACCATGAGCACCACCATGCCCACCTAATTAACTTATTTATTTATTTATTTACTTAGAGACAGGGTCTTACTATGTTGCCCAAGCTGGGCTTGAACTCCTGGCCTCAAGAGATCCTCCTGCCTGAGGCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCACCCAGCCAAAAGTTATTAAAAACTTTAATTCACAGAAAATGAACCAGCAAGCTACCCTTATTGTGAGGGTCAGAGGAGAGAACTAACTTTCCTGATGCCCTGGTGCAGTGGCTCAAGCCCGTAATCCCAATACTTTGGGAAGCCAAAGTGGGGGATTGTTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACATACAAAAAATTTAAAAATTAGATGGGTGTGGTGGTGCACGTCTGTGGTCCCAGCTAATCGGGAGGCTAAGGGAGGAGGACTGCTTGAGGCCAGGAGGTCAAGGCTGCAGTGAGCCATGTTTGTGCCGCTGCACTCCAGCCCGGGCAAAAGAGTGAGACCCTGTTTCAAAAAAAGAAAAGAACTAACATCTTGGGTAGAAATGGTTGATGGCAATATCCATATGTTAATTAGGATAAAGGAATATTTTTACTACTGTAAGAACTCCAAATCATCAAATTCTTCACTGAAATAAGCTTTATGCAGAGTAGTACAATAAGGCAAACATTTTAAGAGGGAAGCAACTGAGATTCTGCACGGACTCTTGTATCATAGGTAGCCATGTCATGGTTAAATGTTCATGTGTAACCATGCTGCCATATACTTTCATGTATAACCAAATTAGCAATTGTGTTTCCCATAATAGTATTTTTCATAGGCTGCCTTATTATGAGTATGTCATGGCTATACATTTATGTTTCCCATAATTAGTACTGACCTCAACAAATAGTAAGTACCCACTAAATTATTTGTTAAAATAATTTTGTAACGAAAGCAGCTAACTTTGGACATAAGAAGGGAGGGGCACTCACGAGAATCAAACTTCCAAGGAATGGTGATGCCGCCAATTTCTGAGTCACTGAATCTCAGGAGGAAGGTCCCATCTGGCTTGTTAATGAGTAGGTCATGGGCCTGTTGCTTGTTTACAAACCCCAAAATGGCCCTGGATCACCAAGGACAAAGGACAGAAGCAGAGTGTGACTTACGATGCCAGAGAGAAGACCTTCAGACTCTGTCGGCGCCTTAAGAAATAATGATTCTCACCCATCATTCCAATGAGGCTTGAGATGTTTTTTTAACACTTCCATCACACCGTCAAACCATTGCCAGAAAGTGTAATTCCGTCCTGGTAAATTCTCCTGGTTGGAGATACAACAGTGAACATAAGAACACCAGAGTAACACTTGGAATATTATACACATATTTAATTGGAAAAATTAAATGGGAAACAAACATCTACCCTTGTCAGAGGCATACAAATATCCCCGCCTACCTGAGTTTTACCTAATGGCCCCATGGAGAGGAAAAGAGGGAAGAAGGGGAAAATACCAAACTGCAGTTACCAGCACCCAGTGGGCTCCTGCTACAGACACTTTCACCTGGGACTGGGCTGACCCGTCCCTTGCTAGTTTCGATGTGTGGTCTGTGACCAGAAGCATCAGTGTCACCTGGGAGCTTCTGAGAAATGCACGTTGTTAGGCTCCAAATTAAACATTTAAAACACCTTGGGGGTGGGGGGTGTAGGAAAAGAAACAAAAATTAAATTCAAATCAAGGTGATAGCCGGGCATGGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCTGAGGTAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTGGCTGGACATGGTGGCGGGTGCCTGTAATCCCGGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAATCTGGGAGACGGAGGTTGCAGTGAGCCCAGAATGTACCACTGCACTCCTTGTGACAGAGCGAGACACCATCTCAAAAATAAATAAATAAACAAAAATAAATAGGGTGGGCACAGTGGACTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCCACTAAAAATACAAAATTGCGGGGCGTGGTGCCGCATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAAACCAGGAGGCGGCGGTTGCGGTGAGCCAAGATCGTGCCATTGCAGTCCAGCCTGGGCAACAAGAGCGAAACTCTGTCTCAAAAAAAAAAAATGAATAAAAATAAAATCAAAGTGACGTCTGAATTAGCAGATGCTAGAGGAGGAGTTTCTTTCATCAGCATCCCTCTTTGTGGGTTGAGGGTCCCATAGGAGCCTGATCTGGCATTACACATGGGGAACATAAGAGAGTAAAGGGGAGAGAGGCCCAGAGTTCGCATCCCCTCAAAAGCTTTGCTTCTCATGAGCTATGTTAACATCTGCTTTGCTCTATTTCCTTTACAAAGGAAGAAAATGCATTAACTGTAGACAAAGGTCAACTTATTTAAAATATGCAAAGATGTAATTTTCTACACGTGACCTGGGTAACTCTCAAGTTGTCCATCTAGTCAGAAGCTTCTATTACTTTCGGTACATTTTATTAGAGACATGAAGAATAAGGGCCCAGGGCAGGGAGACTCCTGAGAGCATCTGGTTGGGAAGGACTGATCTAACAGCGGCTGGCAGCTGGGCTCCTCACCCTGTTGAACTGGGACCAGGACACAGACAGGCCACTGTAGTCCTCCAGGTGGCTGCTGCTGTTGTTGAACAGTTTCTGCGCCAGGAACACGAGGTTCTCCTTGGTCAGGCCCCGGTTGCTCTGCACTTCGGCCTTGAATTTCATGTTGAGCGCCTCACACAGCTGTGGCCACAGCACTTTGTCAGGCACGGCAAATGGCACCCTGCCCTGAGAGGGAGAGAGGCCAGAATCTGATGAGAAAACAGTTGCATGA
Task1_train_24351
Assess the clinical impact of this variant on gene STAT5B (signal transducer and activator of transcription 5B), found on Chromosome 17. State whether it’s pathogenic or benign, and the disease if applicable.
Pathogenic; Growth hormone insensitivity with immune dysregulation 1, autosomal recessive
GGTGGCATGCACCTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGAAGGCAGAAGCTGCAGTGAGCCGAGATAATGCCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAATAGCATAAGATGTAAGTAGTCATTAACATAGCTGAGAATGTTAAAAATGCTTATTTATTTAGACAAGATACTTGAGTAATTACATGGTGCAGGAGATGCCAAAGGTACACAGAGAGTGAGATCTGTGGACAGGCAGGGAAGGAAACAAGAGATGTGGCAATCTTATCTAGGAGGCTTATCAGGACAAGAGGCAGACAGACAGTTTCAAAAAGGAGCTTCTGATTCAGAGTTTGTAAGTGAAGTATGGTAAATCTCTTAAAAATCTCACCTTTGCAGTAAAATACTTTTTCTCTAAAGAGGAGTGTTGGGAAACGTTAAGCCTCTCCACGTGAGCCAGAAGGTTCCATTTCACCTTCTTTACACACAACTGGAAGGTAACCCATGCTGTCCATGCTGTTTTGTAAATGAGCTGTTGAACTAACAGTCAAATCCTATATTCTAACAGCCACAAAACAAAACATAATCAAGGTTTGTTGGATATACTTAGAGAAGGACATGCTCTTATGTCCCAAATGATAACCCTTTTATCATGCTTTTATGGACTAATCTCTATTGGAAATATGTAACAAATGACCTTTGCCTACTAAAAAAATTTTTTTCTTTGAGACAGGGTGTCGCTTTGTCACCCAGGCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAGCCTGGACCTCCTGGGCTCAGGCGATCCTCCCGCCTCAGCCCCCCCCAAGTAGCTGGGACTAGAGGCTGGTGTACCATGCCTGGCTAATTTTTTGGTATTTTTTGTAGAGACAGGATTTTGCTATGCTGCCTAGGCTAGTCTGGAGCTCAAGGGATCTGCCTGCCTTGGCCTCCTGGAGTGCTGGGATTATAGGCATGAGCCACCGCACCCAGCCTATGAGATCTTTAAAATGCTCATCGAGCAGCATGCTAGTGGGATTCAGATAGCGTTTGGGTGCATAAATCCACCAAATTATATCTTCCTTGAGGCAAAGTATCTCATTCTTCATGAGACCTAGAATGAATCACAGAAACTAAAATTTGGAAAAGACATTTAACAGCATCTTCATTTATTGAAAGGAAGAGGGTATGAAGCAACTTCTATGCTAAAGTAAGCCTCTGGAGAGATCTAACCTCTGGAGTGAACCTAGGAGTCCCAAATCCCATTCATAGTTTCACCCAAGGATTCAAAATAATATTTACTGAGTACTGACTGTGTGGCAAGCATTTTCTATGTTATCTAATTTAATCTTCCTAACAATGCTGTAGAGCAAGAGTATCCCTGTGCTGCAGACACTTGCTGGAAACTCAGGCTCAGAGAGGTAAAGTGAACTGCCCATGTGGTCATGGAGTGAGGAAATGGTGGAGTCTCAGTTCAAACCCTGGCCCGATGTCAAGCCCATGTTCTTTCCACTTTCCACATTCTTTCTATTCTGCCTCCCACTAAAGAAAACAGCGTCTTTTTTCCTATGCTTTTTTTTTATTATTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCGCTCGGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTCGGTATTTTTTAATAGAAACAGGATTTTGCTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGTCACTGCACCCGGCCTTTTCCTATGCTTTTTAAAAGGATAATACATAAATGAGATTCATGACACCGGCATTGATTTTGGGACCCACATGCCCGAGGAATACACTCACAGGCTCTGCAAAAGCATTGTCCCAGAGAACAGTGGCCGTCGCATTGTTGTCCTGGCTGCCATGAACGATCACCACCACTGGCAGGGACAGGGTCTAAAAAGACACAAGAGAAGGCTGAGCGCCCACGAGCCTCAAGTTCTTCTCCTTCTCTCTTTTTTTTTTTTCTTATTATAACAACACTTTTATTTTCCAAGTTTCAGTTAATGTTCCTCTCAGACACAGAATCTAAATGGCCCCAGGAATAATATGACTTTTCATACTGGCACAATCTTAGAAATTTTAAATATTTTACAAGCAATGTTGCTTAGATATTTCTGAAGGATAAAGTTTCTCAAAGTTACATGGAGAACAGGAGAGAGAAAAGACTATTGGAGATATTTCTGGGAAGAAAATACAAATAACAAATTTAAAACTTACCACAACCTTTACTCAAATTCATCCCAAGTAATGTTTCTCATATCCATTTTGTAGTCTACCTCTCCAGCTAGTTCAGTTCATTATTGTTTGTTCATGTTTTATTTTTTATTTTTTAATTTGTTGTTGTTGTTGAGACGGGGTCTCACAACCAGCTCCAGGCTGGTCTGGAACTCCTGAACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGATTACAGATGTGAGCCACTGCACTGGGCCTTGCTTGTTCATGTCTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGTTCATTACAACCTCAGCCTCCCAGGTTCAAGTGATTCTCCTGAGTAGCTGGGATTATAGGCACGTGCCACCACGCCTGGCTAATTTTTGTACTTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGCTGGTCTTGAACTCTTGACCTCAAGTGACCTGACTGCCTCAACCTACCAAAGTGCTGGGATTACAAGCATGAGCCACTGTGCTTGGCCTCTGTTCATGTCTTAAGAGAACCTAAGTGAAACAGTTCTCAGGGTGAGGTCAGTCCATTTTCAGTTTACCAACAGTCAAAAAGAAGAAGATGCTATGTGATAAAAAAAAAATATTTTGTAACATAAAGTACACCACACACACACACGCACACGCACACGCAGAGCTGAGGGAAGGCTTTACCTTGACTTGAAAAACCAGCTCATTTCCACCAACACTGAACTGGGATTCAAACAGGATTGTAAATTTTTCTTCTGTCACCGACTCTGCCCCACGACGGTCTGACCTCTTAATTCGTTTCAGGGACTACAAAGAAGAAACATAAGATGAAACGTAAGATATAAGTTGTTCCCCTCAAAGACCAGGGAAAAATTCATTCTTCCTCTTCTTCCACCCTCACCATATTCCTGAAGTGGGCACTAAGGGTGCCTGTGGCTTGGTGGTACTCCATGACGCAGCAGTTGTTCAAGATCTCGCCACTGTAATCACTGCAAATCAGAGAGAGACCAGCTCCAAACCCATGCCAGGGTCTCAGGACATGCGGAGTAAATAATATAATTTGGGGTAGCAGGAAATAGAGAAGTTTGCTAAAAATGTACGTCATTTAGAGGAAATGTTAGCTACATAACACATACATGTAATCTTCTCGGACGTATCTCTACAAAATGAAACAAGATCAAACTATCTTCACAGAAAACAGTTCCTAAGAGAACTTTTTTTTTTTTTTTTGTGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAATCTCAGCTCACTGCAATCTCTGCCTCCCAGGTTCAAGGGATTCTCCTGCCTCAGGCTCTCTAGTGGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCTTAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCAGGCCCAAGAACTTCCTTATATTCCTTTGCTGATGCCCAGAAGAGGCCAGAAGGGCAAACAGGGATCTGACACAGGAGGCAGAATTCTTTTTTTCCTGTTG
GGTGGCATGCACCTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGAAGGCAGAAGCTGCAGTGAGCCGAGATAATGCCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAATAGCATAAGATGTAAGTAGTCATTAACATAGCTGAGAATGTTAAAAATGCTTATTTATTTAGACAAGATACTTGAGTAATTACATGGTGCAGGAGATGCCAAAGGTACACAGAGAGTGAGATCTGTGGACAGGCAGGGAAGGAAACAAGAGATGTGGCAATCTTATCTAGGAGGCTTATCAGGACAAGAGGCAGACAGACAGTTTCAAAAAGGAGCTTCTGATTCAGAGTTTGTAAGTGAAGTATGGTAAATCTCTTAAAAATCTCACCTTTGCAGTAAAATACTTTTTCTCTAAAGAGGAGTGTTGGGAAACGTTAAGCCTCTCCACGTGAGCCAGAAGGTTCCATTTCACCTTCTTTACACACAACTGGAAGGTAACCCATGCTGTCCATGCTGTTTTGTAAATGAGCTGTTGAACTAACAGTCAAATCCTATATTCTAACAGCCACAAAACAAAACATAATCAAGGTTTGTTGGATATACTTAGAGAAGGACATGCTCTTATGTCCCAAATGATAACCCTTTTATCATGCTTTTATGGACTAATCTCTATTGGAAATATGTAACAAATGACCTTTGCCTACTAAAAAAATTTTTTTCTTTGAGACAGGGTGTCGCTTTGTCACCCAGGCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAGCCTGGACCTCCTGGGCTCAGGCGATCCTCCCGCCTCAGCCCCCCCCAAGTAGCTGGGACTAGAGGCTGGTGTACCATGCCTGGCTAATTTTTTGGTATTTTTTGTAGAGACAGGATTTTGCTATGCTGCCTAGGCTAGTCTGGAGCTCAAGGGATCTGCCTGCCTTGGCCTCCTGGAGTGCTGGGATTATAGGCATGAGCCACCGCACCCAGCCTATGAGATCTTTAAAATGCTCATCGAGCAGCATGCTAGTGGGATTCAGATAGCGTTTGGGTGCATAAATCCACCAAATTATATCTTCCTTGAGGCAAAGTATCTCATTCTTCATGAGACCTAGAATGAATCACAGAAACTAAAATTTGGAAAAGACATTTAACAGCATCTTCATTTATTGAAAGGAAGAGGGTATGAAGCAACTTCTATGCTAAAGTAAGCCTCTGGAGAGATCTAACCTCTGGAGTGAACCTAGGAGTCCCAAATCCCATTCATAGTTTCACCCAAGGATTCAAAATAATATTTACTGAGTACTGACTGTGTGGCAAGCATTTTCTATGTTATCTAATTTAATCTTCCTAACAATGCTGTAGAGCAAGAGTATCCCTGTGCTGCAGACACTTGCTGGAAACTCAGGCTCAGAGAGGTAAAGTGAACTGCCCATGTGGTCATGGAGTGAGGAAATGGTGGAGTCTCAGTTCAAACCCTGGCCCGATGTCAAGCCCATGTTCTTTCCACTTTCCACATTCTTTCTATTCTGCCTCCCACTAAAGAAAACAGCGTCTTTTTTCCTATGCTTTTTTTTTATTATTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCGCTCGGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTCGGTATTTTTTAATAGAAACAGGATTTTGCTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGTCACTGCACCCGGCCTTTTCCTATGCTTTTTAAAAGGATAATACATAAATGAGATTCATGACACCGGCATTGATTTTGGGACCCACATGCCCGAGGAATACACTCACAGGCTCTGCAAAAGCATTGTCCCAGAGAACAGTGGCCGTCACATTGTTGTCCTGGCTGCCATGAACGATCACCACCACTGGCAGGGACAGGGTCTAAAAAGACACAAGAGAAGGCTGAGCGCCCACGAGCCTCAAGTTCTTCTCCTTCTCTCTTTTTTTTTTTTCTTATTATAACAACACTTTTATTTTCCAAGTTTCAGTTAATGTTCCTCTCAGACACAGAATCTAAATGGCCCCAGGAATAATATGACTTTTCATACTGGCACAATCTTAGAAATTTTAAATATTTTACAAGCAATGTTGCTTAGATATTTCTGAAGGATAAAGTTTCTCAAAGTTACATGGAGAACAGGAGAGAGAAAAGACTATTGGAGATATTTCTGGGAAGAAAATACAAATAACAAATTTAAAACTTACCACAACCTTTACTCAAATTCATCCCAAGTAATGTTTCTCATATCCATTTTGTAGTCTACCTCTCCAGCTAGTTCAGTTCATTATTGTTTGTTCATGTTTTATTTTTTATTTTTTAATTTGTTGTTGTTGTTGAGACGGGGTCTCACAACCAGCTCCAGGCTGGTCTGGAACTCCTGAACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGATTACAGATGTGAGCCACTGCACTGGGCCTTGCTTGTTCATGTCTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGTTCATTACAACCTCAGCCTCCCAGGTTCAAGTGATTCTCCTGAGTAGCTGGGATTATAGGCACGTGCCACCACGCCTGGCTAATTTTTGTACTTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGCTGGTCTTGAACTCTTGACCTCAAGTGACCTGACTGCCTCAACCTACCAAAGTGCTGGGATTACAAGCATGAGCCACTGTGCTTGGCCTCTGTTCATGTCTTAAGAGAACCTAAGTGAAACAGTTCTCAGGGTGAGGTCAGTCCATTTTCAGTTTACCAACAGTCAAAAAGAAGAAGATGCTATGTGATAAAAAAAAAATATTTTGTAACATAAAGTACACCACACACACACACGCACACGCACACGCAGAGCTGAGGGAAGGCTTTACCTTGACTTGAAAAACCAGCTCATTTCCACCAACACTGAACTGGGATTCAAACAGGATTGTAAATTTTTCTTCTGTCACCGACTCTGCCCCACGACGGTCTGACCTCTTAATTCGTTTCAGGGACTACAAAGAAGAAACATAAGATGAAACGTAAGATATAAGTTGTTCCCCTCAAAGACCAGGGAAAAATTCATTCTTCCTCTTCTTCCACCCTCACCATATTCCTGAAGTGGGCACTAAGGGTGCCTGTGGCTTGGTGGTACTCCATGACGCAGCAGTTGTTCAAGATCTCGCCACTGTAATCACTGCAAATCAGAGAGAGACCAGCTCCAAACCCATGCCAGGGTCTCAGGACATGCGGAGTAAATAATATAATTTGGGGTAGCAGGAAATAGAGAAGTTTGCTAAAAATGTACGTCATTTAGAGGAAATGTTAGCTACATAACACATACATGTAATCTTCTCGGACGTATCTCTACAAAATGAAACAAGATCAAACTATCTTCACAGAAAACAGTTCCTAAGAGAACTTTTTTTTTTTTTTTTGTGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAATCTCAGCTCACTGCAATCTCTGCCTCCCAGGTTCAAGGGATTCTCCTGCCTCAGGCTCTCTAGTGGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCTTAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCAGGCCCAAGAACTTCCTTATATTCCTTTGCTGATGCCCAGAAGAGGCCAGAAGGGCAAACAGGGATCTGACACAGGAGGCAGAATTCTTTTTTTCCTGTTG
Task1_train_24352
The gene STAT5B (signal transducer and activator of transcription 5B) on Chromosome 17 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant
GGTGGCATGCACCTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGAAGGCAGAAGCTGCAGTGAGCCGAGATAATGCCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAATAGCATAAGATGTAAGTAGTCATTAACATAGCTGAGAATGTTAAAAATGCTTATTTATTTAGACAAGATACTTGAGTAATTACATGGTGCAGGAGATGCCAAAGGTACACAGAGAGTGAGATCTGTGGACAGGCAGGGAAGGAAACAAGAGATGTGGCAATCTTATCTAGGAGGCTTATCAGGACAAGAGGCAGACAGACAGTTTCAAAAAGGAGCTTCTGATTCAGAGTTTGTAAGTGAAGTATGGTAAATCTCTTAAAAATCTCACCTTTGCAGTAAAATACTTTTTCTCTAAAGAGGAGTGTTGGGAAACGTTAAGCCTCTCCACGTGAGCCAGAAGGTTCCATTTCACCTTCTTTACACACAACTGGAAGGTAACCCATGCTGTCCATGCTGTTTTGTAAATGAGCTGTTGAACTAACAGTCAAATCCTATATTCTAACAGCCACAAAACAAAACATAATCAAGGTTTGTTGGATATACTTAGAGAAGGACATGCTCTTATGTCCCAAATGATAACCCTTTTATCATGCTTTTATGGACTAATCTCTATTGGAAATATGTAACAAATGACCTTTGCCTACTAAAAAAATTTTTTTCTTTGAGACAGGGTGTCGCTTTGTCACCCAGGCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAGCCTGGACCTCCTGGGCTCAGGCGATCCTCCCGCCTCAGCCCCCCCCAAGTAGCTGGGACTAGAGGCTGGTGTACCATGCCTGGCTAATTTTTTGGTATTTTTTGTAGAGACAGGATTTTGCTATGCTGCCTAGGCTAGTCTGGAGCTCAAGGGATCTGCCTGCCTTGGCCTCCTGGAGTGCTGGGATTATAGGCATGAGCCACCGCACCCAGCCTATGAGATCTTTAAAATGCTCATCGAGCAGCATGCTAGTGGGATTCAGATAGCGTTTGGGTGCATAAATCCACCAAATTATATCTTCCTTGAGGCAAAGTATCTCATTCTTCATGAGACCTAGAATGAATCACAGAAACTAAAATTTGGAAAAGACATTTAACAGCATCTTCATTTATTGAAAGGAAGAGGGTATGAAGCAACTTCTATGCTAAAGTAAGCCTCTGGAGAGATCTAACCTCTGGAGTGAACCTAGGAGTCCCAAATCCCATTCATAGTTTCACCCAAGGATTCAAAATAATATTTACTGAGTACTGACTGTGTGGCAAGCATTTTCTATGTTATCTAATTTAATCTTCCTAACAATGCTGTAGAGCAAGAGTATCCCTGTGCTGCAGACACTTGCTGGAAACTCAGGCTCAGAGAGGTAAAGTGAACTGCCCATGTGGTCATGGAGTGAGGAAATGGTGGAGTCTCAGTTCAAACCCTGGCCCGATGTCAAGCCCATGTTCTTTCCACTTTCCACATTCTTTCTATTCTGCCTCCCACTAAAGAAAACAGCGTCTTTTTTCCTATGCTTTTTTTTTATTATTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCGCTCGGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTCGGTATTTTTTAATAGAAACAGGATTTTGCTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGTCACTGCACCCGGCCTTTTCCTATGCTTTTTAAAAGGATAATACATAAATGAGATTCATGACACCGGCATTGATTTTGGGACCCACATGCCCGAGGAATACACTCACAGGCTCTGCAAAAGCATTGTCCCAGAGAACAGTGGCCGTCGCATTGTTGTCCTGGCTGCCATGAACGATCACCACCACTGGCAGGGACAGGGTCTAAAAAGACACAAGAGAAGGCTGAGCGCCCACGAGCCTCAAGTTCTTCTCCTTCTCTCTTTTTTTTTTTTCTTATTATAACAACACTTTTATTTTCCAAGTTTCAGTTAATGTTCCTCTCAGACACAGAATCTAAATGGCCCCAGGAATAATATGACTTTTCATACTGGCACAATCTTAGAAATTTTAAATATTTTACAAGCAATGTTGCTTAGATATTTCTGAAGGATAAAGTTTCTCAAAGTTACATGGAGAACAGGAGAGAGAAAAGACTATTGGAGATATTTCTGGGAAGAAAATACAAATAACAAATTTAAAACTTACCACAACCTTTACTCAAATTCATCCCAAGTAATGTTTCTCATATCCATTTTGTAGTCTACCTCTCCAGCTAGTTCAGTTCATTATTGTTTGTTCATGTTTTATTTTTTATTTTTTAATTTGTTGTTGTTGTTGAGACGGGGTCTCACAACCAGCTCCAGGCTGGTCTGGAACTCCTGAACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGATTACAGATGTGAGCCACTGCACTGGGCCTTGCTTGTTCATGTCTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGTTCATTACAACCTCAGCCTCCCAGGTTCAAGTGATTCTCCTGAGTAGCTGGGATTATAGGCACGTGCCACCACGCCTGGCTAATTTTTGTACTTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGCTGGTCTTGAACTCTTGACCTCAAGTGACCTGACTGCCTCAACCTACCAAAGTGCTGGGATTACAAGCATGAGCCACTGTGCTTGGCCTCTGTTCATGTCTTAAGAGAACCTAAGTGAAACAGTTCTCAGGGTGAGGTCAGTCCATTTTCAGTTTACCAACAGTCAAAAAGAAGAAGATGCTATGTGATAAAAAAAAAATATTTTGTAACATAAAGTACACCACACACACACACGCACACGCACACGCAGAGCTGAGGGAAGGCTTTACCTTGACTTGAAAAACCAGCTCATTTCCACCAACACTGAACTGGGATTCAAACAGGATTGTAAATTTTTCTTCTGTCACCGACTCTGCCCCACGACGGTCTGACCTCTTAATTCGTTTCAGGGACTACAAAGAAGAAACATAAGATGAAACGTAAGATATAAGTTGTTCCCCTCAAAGACCAGGGAAAAATTCATTCTTCCTCTTCTTCCACCCTCACCATATTCCTGAAGTGGGCACTAAGGGTGCCTGTGGCTTGGTGGTACTCCATGACGCAGCAGTTGTTCAAGATCTCGCCACTGTAATCACTGCAAATCAGAGAGAGACCAGCTCCAAACCCATGCCAGGGTCTCAGGACATGCGGAGTAAATAATATAATTTGGGGTAGCAGGAAATAGAGAAGTTTGCTAAAAATGTACGTCATTTAGAGGAAATGTTAGCTACATAACACATACATGTAATCTTCTCGGACGTATCTCTACAAAATGAAACAAGATCAAACTATCTTCACAGAAAACAGTTCCTAAGAGAACTTTTTTTTTTTTTTTTGTGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAATCTCAGCTCACTGCAATCTCTGCCTCCCAGGTTCAAGGGATTCTCCTGCCTCAGGCTCTCTAGTGGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCTTAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCAGGCCCAAGAACTTCCTTATATTCCTTTGCTGATGCCCAGAAGAGGCCAGAAGGGCAAACAGGGATCTGACACAGGAGGCAGAATTCTTTTTTTCCTGTTG
GGTGGCATGCACCTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGAAGGCAGAAGCTGCAGTGAGCCGAGATAATGCCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAATAGCATAAGATGTAAGTAGTCATTAACATAGCTGAGAATGTTAAAAATGCTTATTTATTTAGACAAGATACTTGAGTAATTACATGGTGCAGGAGATGCCAAAGGTACACAGAGAGTGAGATCTGTGGACAGGCAGGGAAGGAAACAAGAGATGTGGCAATCTTATCTAGGAGGCTTATCAGGACAAGAGGCAGACAGACAGTTTCAAAAAGGAGCTTCTGATTCAGAGTTTGTAAGTGAAGTATGGTAAATCTCTTAAAAATCTCACCTTTGCAGTAAAATACTTTTTCTCTAAAGAGGAGTGTTGGGAAACGTTAAGCCTCTCCACGTGAGCCAGAAGGTTCCATTTCACCTTCTTTACACACAACTGGAAGGTAACCCATGCTGTCCATGCTGTTTTGTAAATGAGCTGTTGAACTAACAGTCAAATCCTATATTCTAACAGCCACAAAACAAAACATAATCAAGGTTTGTTGGATATACTTAGAGAAGGACATGCTCTTATGTCCCAAATGATAACCCTTTTATCATGCTTTTATGGACTAATCTCTATTGGAAATATGTAACAAATGACCTTTGCCTACTAAAAAAATTTTTTTCTTTGAGACAGGGTGTCGCTTTGTCACCCAGGCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAGCCTGGACCTCCTGGGCTCAGGCGATCCTCCCGCCTCAGCCCCCCCCAAGTAGCTGGGACTAGAGGCTGGTGTACCATGCCTGGCTAATTTTTTGGTATTTTTTGTAGAGACAGGATTTTGCTATGCTGCCTAGGCTAGTCTGGAGCTCAAGGGATCTGCCTGCCTTGGCCTCCTGGAGTGCTGGGATTATAGGCATGAGCCACCGCACCCAGCCTATGAGATCTTTAAAATGCTCATCGAGCAGCATGCTAGTGGGATTCAGATAGCGTTTGGGTGCATAAATCCACCAAATTATATCTTCCTTGAGGCAAAGTATCTCATTCTTCATGAGACCTAGAATGAATCACAGAAACTAAAATTTGGAAAAGACATTTAACAGCATCTTCATTTATTGAAAGGAAGAGGGTATGAAGCAACTTCTATGCTAAAGTAAGCCTCTGGAGAGATCTAACCTCTGGAGTGAACCTAGGAGTCCCAAATCCCATTCATAGTTTCACCCAAGGATTCAAAATAATATTTACTGAGTACTGACTGTGTGGCAAGCATTTTCTATGTTATCTAATTTAATCTTCCTAACAATGCTGTAGAGCAAGAGTATCCCTGTGCTGCAGACACTTGCTGGAAACTCAGGCTCAGAGAGGTAAAGTGAACTGCCCATGTGGTCATGGAGTGAGGAAATGGTGGAGTCTCAGTTCAAACCCTGGCCCGATGTCAAGCCCATGTTCTTTCCACTTTCCACATTCTTTCTATTCTGCCTCCCACTAAAGAAAACAGCGTCTTTTTTCCTATGCTTTTTTTTTATTATTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCGCTCGGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTCGGTATTTTTTAATAGAAACAGGATTTTGCTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGTCACTGCACCCGGCCTTTTCCTATGCTTTTTAAAAGGATAATACATAAATGAGATTCATGACACCGGCATTGATTTTGGGACCCACATGCCCGAGGAATACACTCACAGGCTCTGCAAAAGCATTGTCCCAGAGAACAGTGGCCGTCACATTGTTGTCCTGGCTGCCATGAACGATCACCACCACTGGCAGGGACAGGGTCTAAAAAGACACAAGAGAAGGCTGAGCGCCCACGAGCCTCAAGTTCTTCTCCTTCTCTCTTTTTTTTTTTTCTTATTATAACAACACTTTTATTTTCCAAGTTTCAGTTAATGTTCCTCTCAGACACAGAATCTAAATGGCCCCAGGAATAATATGACTTTTCATACTGGCACAATCTTAGAAATTTTAAATATTTTACAAGCAATGTTGCTTAGATATTTCTGAAGGATAAAGTTTCTCAAAGTTACATGGAGAACAGGAGAGAGAAAAGACTATTGGAGATATTTCTGGGAAGAAAATACAAATAACAAATTTAAAACTTACCACAACCTTTACTCAAATTCATCCCAAGTAATGTTTCTCATATCCATTTTGTAGTCTACCTCTCCAGCTAGTTCAGTTCATTATTGTTTGTTCATGTTTTATTTTTTATTTTTTAATTTGTTGTTGTTGTTGAGACGGGGTCTCACAACCAGCTCCAGGCTGGTCTGGAACTCCTGAACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGATTACAGATGTGAGCCACTGCACTGGGCCTTGCTTGTTCATGTCTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGTTCATTACAACCTCAGCCTCCCAGGTTCAAGTGATTCTCCTGAGTAGCTGGGATTATAGGCACGTGCCACCACGCCTGGCTAATTTTTGTACTTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGCTGGTCTTGAACTCTTGACCTCAAGTGACCTGACTGCCTCAACCTACCAAAGTGCTGGGATTACAAGCATGAGCCACTGTGCTTGGCCTCTGTTCATGTCTTAAGAGAACCTAAGTGAAACAGTTCTCAGGGTGAGGTCAGTCCATTTTCAGTTTACCAACAGTCAAAAAGAAGAAGATGCTATGTGATAAAAAAAAAATATTTTGTAACATAAAGTACACCACACACACACACGCACACGCACACGCAGAGCTGAGGGAAGGCTTTACCTTGACTTGAAAAACCAGCTCATTTCCACCAACACTGAACTGGGATTCAAACAGGATTGTAAATTTTTCTTCTGTCACCGACTCTGCCCCACGACGGTCTGACCTCTTAATTCGTTTCAGGGACTACAAAGAAGAAACATAAGATGAAACGTAAGATATAAGTTGTTCCCCTCAAAGACCAGGGAAAAATTCATTCTTCCTCTTCTTCCACCCTCACCATATTCCTGAAGTGGGCACTAAGGGTGCCTGTGGCTTGGTGGTACTCCATGACGCAGCAGTTGTTCAAGATCTCGCCACTGTAATCACTGCAAATCAGAGAGAGACCAGCTCCAAACCCATGCCAGGGTCTCAGGACATGCGGAGTAAATAATATAATTTGGGGTAGCAGGAAATAGAGAAGTTTGCTAAAAATGTACGTCATTTAGAGGAAATGTTAGCTACATAACACATACATGTAATCTTCTCGGACGTATCTCTACAAAATGAAACAAGATCAAACTATCTTCACAGAAAACAGTTCCTAAGAGAACTTTTTTTTTTTTTTTTGTGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAATCTCAGCTCACTGCAATCTCTGCCTCCCAGGTTCAAGGGATTCTCCTGCCTCAGGCTCTCTAGTGGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCTTAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCAGGCCCAAGAACTTCCTTATATTCCTTTGCTGATGCCCAGAAGAGGCCAGAAGGGCAAACAGGGATCTGACACAGGAGGCAGAATTCTTTTTTTCCTGTTG
Task1_train_24353
A mutation found in STAT5B (signal transducer and activator of transcription 5B) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant
CTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGAAGGCAGAAGCTGCAGTGAGCCGAGATAATGCCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAATAGCATAAGATGTAAGTAGTCATTAACATAGCTGAGAATGTTAAAAATGCTTATTTATTTAGACAAGATACTTGAGTAATTACATGGTGCAGGAGATGCCAAAGGTACACAGAGAGTGAGATCTGTGGACAGGCAGGGAAGGAAACAAGAGATGTGGCAATCTTATCTAGGAGGCTTATCAGGACAAGAGGCAGACAGACAGTTTCAAAAAGGAGCTTCTGATTCAGAGTTTGTAAGTGAAGTATGGTAAATCTCTTAAAAATCTCACCTTTGCAGTAAAATACTTTTTCTCTAAAGAGGAGTGTTGGGAAACGTTAAGCCTCTCCACGTGAGCCAGAAGGTTCCATTTCACCTTCTTTACACACAACTGGAAGGTAACCCATGCTGTCCATGCTGTTTTGTAAATGAGCTGTTGAACTAACAGTCAAATCCTATATTCTAACAGCCACAAAACAAAACATAATCAAGGTTTGTTGGATATACTTAGAGAAGGACATGCTCTTATGTCCCAAATGATAACCCTTTTATCATGCTTTTATGGACTAATCTCTATTGGAAATATGTAACAAATGACCTTTGCCTACTAAAAAAATTTTTTTCTTTGAGACAGGGTGTCGCTTTGTCACCCAGGCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAGCCTGGACCTCCTGGGCTCAGGCGATCCTCCCGCCTCAGCCCCCCCCAAGTAGCTGGGACTAGAGGCTGGTGTACCATGCCTGGCTAATTTTTTGGTATTTTTTGTAGAGACAGGATTTTGCTATGCTGCCTAGGCTAGTCTGGAGCTCAAGGGATCTGCCTGCCTTGGCCTCCTGGAGTGCTGGGATTATAGGCATGAGCCACCGCACCCAGCCTATGAGATCTTTAAAATGCTCATCGAGCAGCATGCTAGTGGGATTCAGATAGCGTTTGGGTGCATAAATCCACCAAATTATATCTTCCTTGAGGCAAAGTATCTCATTCTTCATGAGACCTAGAATGAATCACAGAAACTAAAATTTGGAAAAGACATTTAACAGCATCTTCATTTATTGAAAGGAAGAGGGTATGAAGCAACTTCTATGCTAAAGTAAGCCTCTGGAGAGATCTAACCTCTGGAGTGAACCTAGGAGTCCCAAATCCCATTCATAGTTTCACCCAAGGATTCAAAATAATATTTACTGAGTACTGACTGTGTGGCAAGCATTTTCTATGTTATCTAATTTAATCTTCCTAACAATGCTGTAGAGCAAGAGTATCCCTGTGCTGCAGACACTTGCTGGAAACTCAGGCTCAGAGAGGTAAAGTGAACTGCCCATGTGGTCATGGAGTGAGGAAATGGTGGAGTCTCAGTTCAAACCCTGGCCCGATGTCAAGCCCATGTTCTTTCCACTTTCCACATTCTTTCTATTCTGCCTCCCACTAAAGAAAACAGCGTCTTTTTTCCTATGCTTTTTTTTTATTATTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCGCTCGGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTCGGTATTTTTTAATAGAAACAGGATTTTGCTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGTCACTGCACCCGGCCTTTTCCTATGCTTTTTAAAAGGATAATACATAAATGAGATTCATGACACCGGCATTGATTTTGGGACCCACATGCCCGAGGAATACACTCACAGGCTCTGCAAAAGCATTGTCCCAGAGAACAGTGGCCGTCGCATTGTTGTCCTGGCTGCCATGAACGATCACCACCACTGGCAGGGACAGGGTCTAAAAAGACACAAGAGAAGGCTGAGCGCCCACGAGCCTCAAGTTCTTCTCCTTCTCTCTTTTTTTTTTTTCTTATTATAACAACACTTTTATTTTCCAAGTTTCAGTTAATGTTCCTCTCAGACACAGAATCTAAATGGCCCCAGGAATAATATGACTTTTCATACTGGCACAATCTTAGAAATTTTAAATATTTTACAAGCAATGTTGCTTAGATATTTCTGAAGGATAAAGTTTCTCAAAGTTACATGGAGAACAGGAGAGAGAAAAGACTATTGGAGATATTTCTGGGAAGAAAATACAAATAACAAATTTAAAACTTACCACAACCTTTACTCAAATTCATCCCAAGTAATGTTTCTCATATCCATTTTGTAGTCTACCTCTCCAGCTAGTTCAGTTCATTATTGTTTGTTCATGTTTTATTTTTTATTTTTTAATTTGTTGTTGTTGTTGAGACGGGGTCTCACAACCAGCTCCAGGCTGGTCTGGAACTCCTGAACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGATTACAGATGTGAGCCACTGCACTGGGCCTTGCTTGTTCATGTCTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGTTCATTACAACCTCAGCCTCCCAGGTTCAAGTGATTCTCCTGAGTAGCTGGGATTATAGGCACGTGCCACCACGCCTGGCTAATTTTTGTACTTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGCTGGTCTTGAACTCTTGACCTCAAGTGACCTGACTGCCTCAACCTACCAAAGTGCTGGGATTACAAGCATGAGCCACTGTGCTTGGCCTCTGTTCATGTCTTAAGAGAACCTAAGTGAAACAGTTCTCAGGGTGAGGTCAGTCCATTTTCAGTTTACCAACAGTCAAAAAGAAGAAGATGCTATGTGATAAAAAAAAAATATTTTGTAACATAAAGTACACCACACACACACACGCACACGCACACGCAGAGCTGAGGGAAGGCTTTACCTTGACTTGAAAAACCAGCTCATTTCCACCAACACTGAACTGGGATTCAAACAGGATTGTAAATTTTTCTTCTGTCACCGACTCTGCCCCACGACGGTCTGACCTCTTAATTCGTTTCAGGGACTACAAAGAAGAAACATAAGATGAAACGTAAGATATAAGTTGTTCCCCTCAAAGACCAGGGAAAAATTCATTCTTCCTCTTCTTCCACCCTCACCATATTCCTGAAGTGGGCACTAAGGGTGCCTGTGGCTTGGTGGTACTCCATGACGCAGCAGTTGTTCAAGATCTCGCCACTGTAATCACTGCAAATCAGAGAGAGACCAGCTCCAAACCCATGCCAGGGTCTCAGGACATGCGGAGTAAATAATATAATTTGGGGTAGCAGGAAATAGAGAAGTTTGCTAAAAATGTACGTCATTTAGAGGAAATGTTAGCTACATAACACATACATGTAATCTTCTCGGACGTATCTCTACAAAATGAAACAAGATCAAACTATCTTCACAGAAAACAGTTCCTAAGAGAACTTTTTTTTTTTTTTTTGTGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAATCTCAGCTCACTGCAATCTCTGCCTCCCAGGTTCAAGGGATTCTCCTGCCTCAGGCTCTCTAGTGGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCTTAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCAGGCCCAAGAACTTCCTTATATTCCTTTGCTGATGCCCAGAAGAGGCCAGAAGGGCAAACAGGGATCTGACACAGGAGGCAGAATTCTTTTTTTCCTGTTGCCAGGACATGAG
CTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGAAGGCAGAAGCTGCAGTGAGCCGAGATAATGCCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAATAGCATAAGATGTAAGTAGTCATTAACATAGCTGAGAATGTTAAAAATGCTTATTTATTTAGACAAGATACTTGAGTAATTACATGGTGCAGGAGATGCCAAAGGTACACAGAGAGTGAGATCTGTGGACAGGCAGGGAAGGAAACAAGAGATGTGGCAATCTTATCTAGGAGGCTTATCAGGACAAGAGGCAGACAGACAGTTTCAAAAAGGAGCTTCTGATTCAGAGTTTGTAAGTGAAGTATGGTAAATCTCTTAAAAATCTCACCTTTGCAGTAAAATACTTTTTCTCTAAAGAGGAGTGTTGGGAAACGTTAAGCCTCTCCACGTGAGCCAGAAGGTTCCATTTCACCTTCTTTACACACAACTGGAAGGTAACCCATGCTGTCCATGCTGTTTTGTAAATGAGCTGTTGAACTAACAGTCAAATCCTATATTCTAACAGCCACAAAACAAAACATAATCAAGGTTTGTTGGATATACTTAGAGAAGGACATGCTCTTATGTCCCAAATGATAACCCTTTTATCATGCTTTTATGGACTAATCTCTATTGGAAATATGTAACAAATGACCTTTGCCTACTAAAAAAATTTTTTTCTTTGAGACAGGGTGTCGCTTTGTCACCCAGGCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAGCCTGGACCTCCTGGGCTCAGGCGATCCTCCCGCCTCAGCCCCCCCCAAGTAGCTGGGACTAGAGGCTGGTGTACCATGCCTGGCTAATTTTTTGGTATTTTTTGTAGAGACAGGATTTTGCTATGCTGCCTAGGCTAGTCTGGAGCTCAAGGGATCTGCCTGCCTTGGCCTCCTGGAGTGCTGGGATTATAGGCATGAGCCACCGCACCCAGCCTATGAGATCTTTAAAATGCTCATCGAGCAGCATGCTAGTGGGATTCAGATAGCGTTTGGGTGCATAAATCCACCAAATTATATCTTCCTTGAGGCAAAGTATCTCATTCTTCATGAGACCTAGAATGAATCACAGAAACTAAAATTTGGAAAAGACATTTAACAGCATCTTCATTTATTGAAAGGAAGAGGGTATGAAGCAACTTCTATGCTAAAGTAAGCCTCTGGAGAGATCTAACCTCTGGAGTGAACCTAGGAGTCCCAAATCCCATTCATAGTTTCACCCAAGGATTCAAAATAATATTTACTGAGTACTGACTGTGTGGCAAGCATTTTCTATGTTATCTAATTTAATCTTCCTAACAATGCTGTAGAGCAAGAGTATCCCTGTGCTGCAGACACTTGCTGGAAACTCAGGCTCAGAGAGGTAAAGTGAACTGCCCATGTGGTCATGGAGTGAGGAAATGGTGGAGTCTCAGTTCAAACCCTGGCCCGATGTCAAGCCCATGTTCTTTCCACTTTCCACATTCTTTCTATTCTGCCTCCCACTAAAGAAAACAGCGTCTTTTTTCCTATGCTTTTTTTTTATTATTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCGCTCGGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTCGGTATTTTTTAATAGAAACAGGATTTTGCTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGTCACTGCACCCGGCCTTTTCCTATGCTTTTTAAAAGGATAATACATAAATGAGATTCATGACACCGGCATTGATTTTGGGACCCACATGCCCGAGGAATACACTCACAGGCTCTGCAAAAGCATTGTCCCAGAGAACAGTGGCCGTCGCATTGTTGTCCCGGCTGCCATGAACGATCACCACCACTGGCAGGGACAGGGTCTAAAAAGACACAAGAGAAGGCTGAGCGCCCACGAGCCTCAAGTTCTTCTCCTTCTCTCTTTTTTTTTTTTCTTATTATAACAACACTTTTATTTTCCAAGTTTCAGTTAATGTTCCTCTCAGACACAGAATCTAAATGGCCCCAGGAATAATATGACTTTTCATACTGGCACAATCTTAGAAATTTTAAATATTTTACAAGCAATGTTGCTTAGATATTTCTGAAGGATAAAGTTTCTCAAAGTTACATGGAGAACAGGAGAGAGAAAAGACTATTGGAGATATTTCTGGGAAGAAAATACAAATAACAAATTTAAAACTTACCACAACCTTTACTCAAATTCATCCCAAGTAATGTTTCTCATATCCATTTTGTAGTCTACCTCTCCAGCTAGTTCAGTTCATTATTGTTTGTTCATGTTTTATTTTTTATTTTTTAATTTGTTGTTGTTGTTGAGACGGGGTCTCACAACCAGCTCCAGGCTGGTCTGGAACTCCTGAACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGATTACAGATGTGAGCCACTGCACTGGGCCTTGCTTGTTCATGTCTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGTTCATTACAACCTCAGCCTCCCAGGTTCAAGTGATTCTCCTGAGTAGCTGGGATTATAGGCACGTGCCACCACGCCTGGCTAATTTTTGTACTTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGCTGGTCTTGAACTCTTGACCTCAAGTGACCTGACTGCCTCAACCTACCAAAGTGCTGGGATTACAAGCATGAGCCACTGTGCTTGGCCTCTGTTCATGTCTTAAGAGAACCTAAGTGAAACAGTTCTCAGGGTGAGGTCAGTCCATTTTCAGTTTACCAACAGTCAAAAAGAAGAAGATGCTATGTGATAAAAAAAAAATATTTTGTAACATAAAGTACACCACACACACACACGCACACGCACACGCAGAGCTGAGGGAAGGCTTTACCTTGACTTGAAAAACCAGCTCATTTCCACCAACACTGAACTGGGATTCAAACAGGATTGTAAATTTTTCTTCTGTCACCGACTCTGCCCCACGACGGTCTGACCTCTTAATTCGTTTCAGGGACTACAAAGAAGAAACATAAGATGAAACGTAAGATATAAGTTGTTCCCCTCAAAGACCAGGGAAAAATTCATTCTTCCTCTTCTTCCACCCTCACCATATTCCTGAAGTGGGCACTAAGGGTGCCTGTGGCTTGGTGGTACTCCATGACGCAGCAGTTGTTCAAGATCTCGCCACTGTAATCACTGCAAATCAGAGAGAGACCAGCTCCAAACCCATGCCAGGGTCTCAGGACATGCGGAGTAAATAATATAATTTGGGGTAGCAGGAAATAGAGAAGTTTGCTAAAAATGTACGTCATTTAGAGGAAATGTTAGCTACATAACACATACATGTAATCTTCTCGGACGTATCTCTACAAAATGAAACAAGATCAAACTATCTTCACAGAAAACAGTTCCTAAGAGAACTTTTTTTTTTTTTTTTGTGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAATCTCAGCTCACTGCAATCTCTGCCTCCCAGGTTCAAGGGATTCTCCTGCCTCAGGCTCTCTAGTGGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCTTAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCAGGCCCAAGAACTTCCTTATATTCCTTTGCTGATGCCCAGAAGAGGCCAGAAGGGCAAACAGGGATCTGACACAGGAGGCAGAATTCTTTTTTTCCTGTTGCCAGGACATGAG
Task1_train_24354
Mutation context: Chromosome 17, Gene STAT5B (signal transducer and activator of transcription 5B). Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.
Pathogenic; Growth hormone insensitivity with immune dysregulation 1, autosomal recessive
CTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGAAGGCAGAAGCTGCAGTGAGCCGAGATAATGCCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAATAGCATAAGATGTAAGTAGTCATTAACATAGCTGAGAATGTTAAAAATGCTTATTTATTTAGACAAGATACTTGAGTAATTACATGGTGCAGGAGATGCCAAAGGTACACAGAGAGTGAGATCTGTGGACAGGCAGGGAAGGAAACAAGAGATGTGGCAATCTTATCTAGGAGGCTTATCAGGACAAGAGGCAGACAGACAGTTTCAAAAAGGAGCTTCTGATTCAGAGTTTGTAAGTGAAGTATGGTAAATCTCTTAAAAATCTCACCTTTGCAGTAAAATACTTTTTCTCTAAAGAGGAGTGTTGGGAAACGTTAAGCCTCTCCACGTGAGCCAGAAGGTTCCATTTCACCTTCTTTACACACAACTGGAAGGTAACCCATGCTGTCCATGCTGTTTTGTAAATGAGCTGTTGAACTAACAGTCAAATCCTATATTCTAACAGCCACAAAACAAAACATAATCAAGGTTTGTTGGATATACTTAGAGAAGGACATGCTCTTATGTCCCAAATGATAACCCTTTTATCATGCTTTTATGGACTAATCTCTATTGGAAATATGTAACAAATGACCTTTGCCTACTAAAAAAATTTTTTTCTTTGAGACAGGGTGTCGCTTTGTCACCCAGGCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAGCCTGGACCTCCTGGGCTCAGGCGATCCTCCCGCCTCAGCCCCCCCCAAGTAGCTGGGACTAGAGGCTGGTGTACCATGCCTGGCTAATTTTTTGGTATTTTTTGTAGAGACAGGATTTTGCTATGCTGCCTAGGCTAGTCTGGAGCTCAAGGGATCTGCCTGCCTTGGCCTCCTGGAGTGCTGGGATTATAGGCATGAGCCACCGCACCCAGCCTATGAGATCTTTAAAATGCTCATCGAGCAGCATGCTAGTGGGATTCAGATAGCGTTTGGGTGCATAAATCCACCAAATTATATCTTCCTTGAGGCAAAGTATCTCATTCTTCATGAGACCTAGAATGAATCACAGAAACTAAAATTTGGAAAAGACATTTAACAGCATCTTCATTTATTGAAAGGAAGAGGGTATGAAGCAACTTCTATGCTAAAGTAAGCCTCTGGAGAGATCTAACCTCTGGAGTGAACCTAGGAGTCCCAAATCCCATTCATAGTTTCACCCAAGGATTCAAAATAATATTTACTGAGTACTGACTGTGTGGCAAGCATTTTCTATGTTATCTAATTTAATCTTCCTAACAATGCTGTAGAGCAAGAGTATCCCTGTGCTGCAGACACTTGCTGGAAACTCAGGCTCAGAGAGGTAAAGTGAACTGCCCATGTGGTCATGGAGTGAGGAAATGGTGGAGTCTCAGTTCAAACCCTGGCCCGATGTCAAGCCCATGTTCTTTCCACTTTCCACATTCTTTCTATTCTGCCTCCCACTAAAGAAAACAGCGTCTTTTTTCCTATGCTTTTTTTTTATTATTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCGCTCGGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTCGGTATTTTTTAATAGAAACAGGATTTTGCTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGTCACTGCACCCGGCCTTTTCCTATGCTTTTTAAAAGGATAATACATAAATGAGATTCATGACACCGGCATTGATTTTGGGACCCACATGCCCGAGGAATACACTCACAGGCTCTGCAAAAGCATTGTCCCAGAGAACAGTGGCCGTCGCATTGTTGTCCTGGCTGCCATGAACGATCACCACCACTGGCAGGGACAGGGTCTAAAAAGACACAAGAGAAGGCTGAGCGCCCACGAGCCTCAAGTTCTTCTCCTTCTCTCTTTTTTTTTTTTCTTATTATAACAACACTTTTATTTTCCAAGTTTCAGTTAATGTTCCTCTCAGACACAGAATCTAAATGGCCCCAGGAATAATATGACTTTTCATACTGGCACAATCTTAGAAATTTTAAATATTTTACAAGCAATGTTGCTTAGATATTTCTGAAGGATAAAGTTTCTCAAAGTTACATGGAGAACAGGAGAGAGAAAAGACTATTGGAGATATTTCTGGGAAGAAAATACAAATAACAAATTTAAAACTTACCACAACCTTTACTCAAATTCATCCCAAGTAATGTTTCTCATATCCATTTTGTAGTCTACCTCTCCAGCTAGTTCAGTTCATTATTGTTTGTTCATGTTTTATTTTTTATTTTTTAATTTGTTGTTGTTGTTGAGACGGGGTCTCACAACCAGCTCCAGGCTGGTCTGGAACTCCTGAACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGATTACAGATGTGAGCCACTGCACTGGGCCTTGCTTGTTCATGTCTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGTTCATTACAACCTCAGCCTCCCAGGTTCAAGTGATTCTCCTGAGTAGCTGGGATTATAGGCACGTGCCACCACGCCTGGCTAATTTTTGTACTTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGCTGGTCTTGAACTCTTGACCTCAAGTGACCTGACTGCCTCAACCTACCAAAGTGCTGGGATTACAAGCATGAGCCACTGTGCTTGGCCTCTGTTCATGTCTTAAGAGAACCTAAGTGAAACAGTTCTCAGGGTGAGGTCAGTCCATTTTCAGTTTACCAACAGTCAAAAAGAAGAAGATGCTATGTGATAAAAAAAAAATATTTTGTAACATAAAGTACACCACACACACACACGCACACGCACACGCAGAGCTGAGGGAAGGCTTTACCTTGACTTGAAAAACCAGCTCATTTCCACCAACACTGAACTGGGATTCAAACAGGATTGTAAATTTTTCTTCTGTCACCGACTCTGCCCCACGACGGTCTGACCTCTTAATTCGTTTCAGGGACTACAAAGAAGAAACATAAGATGAAACGTAAGATATAAGTTGTTCCCCTCAAAGACCAGGGAAAAATTCATTCTTCCTCTTCTTCCACCCTCACCATATTCCTGAAGTGGGCACTAAGGGTGCCTGTGGCTTGGTGGTACTCCATGACGCAGCAGTTGTTCAAGATCTCGCCACTGTAATCACTGCAAATCAGAGAGAGACCAGCTCCAAACCCATGCCAGGGTCTCAGGACATGCGGAGTAAATAATATAATTTGGGGTAGCAGGAAATAGAGAAGTTTGCTAAAAATGTACGTCATTTAGAGGAAATGTTAGCTACATAACACATACATGTAATCTTCTCGGACGTATCTCTACAAAATGAAACAAGATCAAACTATCTTCACAGAAAACAGTTCCTAAGAGAACTTTTTTTTTTTTTTTTGTGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAATCTCAGCTCACTGCAATCTCTGCCTCCCAGGTTCAAGGGATTCTCCTGCCTCAGGCTCTCTAGTGGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCTTAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCAGGCCCAAGAACTTCCTTATATTCCTTTGCTGATGCCCAGAAGAGGCCAGAAGGGCAAACAGGGATCTGACACAGGAGGCAGAATTCTTTTTTTCCTGTTGCCAGGACATGAG
CTGTAATCCCAGCTTCTCGGGAGGCTGAGGCAGGAGAATCGCTTGAATCCAGAAGGCAGAAGCTGCAGTGAGCCGAGATAATGCCACTGTACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAATTAAAAAAAAAAAAATAGCATAAGATGTAAGTAGTCATTAACATAGCTGAGAATGTTAAAAATGCTTATTTATTTAGACAAGATACTTGAGTAATTACATGGTGCAGGAGATGCCAAAGGTACACAGAGAGTGAGATCTGTGGACAGGCAGGGAAGGAAACAAGAGATGTGGCAATCTTATCTAGGAGGCTTATCAGGACAAGAGGCAGACAGACAGTTTCAAAAAGGAGCTTCTGATTCAGAGTTTGTAAGTGAAGTATGGTAAATCTCTTAAAAATCTCACCTTTGCAGTAAAATACTTTTTCTCTAAAGAGGAGTGTTGGGAAACGTTAAGCCTCTCCACGTGAGCCAGAAGGTTCCATTTCACCTTCTTTACACACAACTGGAAGGTAACCCATGCTGTCCATGCTGTTTTGTAAATGAGCTGTTGAACTAACAGTCAAATCCTATATTCTAACAGCCACAAAACAAAACATAATCAAGGTTTGTTGGATATACTTAGAGAAGGACATGCTCTTATGTCCCAAATGATAACCCTTTTATCATGCTTTTATGGACTAATCTCTATTGGAAATATGTAACAAATGACCTTTGCCTACTAAAAAAATTTTTTTCTTTGAGACAGGGTGTCGCTTTGTCACCCAGGCTGGAGTACAGTGGCACAATCTTGGCTCACTGCAGCCTGGACCTCCTGGGCTCAGGCGATCCTCCCGCCTCAGCCCCCCCCAAGTAGCTGGGACTAGAGGCTGGTGTACCATGCCTGGCTAATTTTTTGGTATTTTTTGTAGAGACAGGATTTTGCTATGCTGCCTAGGCTAGTCTGGAGCTCAAGGGATCTGCCTGCCTTGGCCTCCTGGAGTGCTGGGATTATAGGCATGAGCCACCGCACCCAGCCTATGAGATCTTTAAAATGCTCATCGAGCAGCATGCTAGTGGGATTCAGATAGCGTTTGGGTGCATAAATCCACCAAATTATATCTTCCTTGAGGCAAAGTATCTCATTCTTCATGAGACCTAGAATGAATCACAGAAACTAAAATTTGGAAAAGACATTTAACAGCATCTTCATTTATTGAAAGGAAGAGGGTATGAAGCAACTTCTATGCTAAAGTAAGCCTCTGGAGAGATCTAACCTCTGGAGTGAACCTAGGAGTCCCAAATCCCATTCATAGTTTCACCCAAGGATTCAAAATAATATTTACTGAGTACTGACTGTGTGGCAAGCATTTTCTATGTTATCTAATTTAATCTTCCTAACAATGCTGTAGAGCAAGAGTATCCCTGTGCTGCAGACACTTGCTGGAAACTCAGGCTCAGAGAGGTAAAGTGAACTGCCCATGTGGTCATGGAGTGAGGAAATGGTGGAGTCTCAGTTCAAACCCTGGCCCGATGTCAAGCCCATGTTCTTTCCACTTTCCACATTCTTTCTATTCTGCCTCCCACTAAAGAAAACAGCGTCTTTTTTCCTATGCTTTTTTTTTATTATTGAGATGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCGCTCGGGTTCAAGTGATTGTCGTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACACCCAGCTAATTTTTCGGTATTTTTTAATAGAAACAGGATTTTGCTATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCAACCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGTGTGAGTCACTGCACCCGGCCTTTTCCTATGCTTTTTAAAAGGATAATACATAAATGAGATTCATGACACCGGCATTGATTTTGGGACCCACATGCCCGAGGAATACACTCACAGGCTCTGCAAAAGCATTGTCCCAGAGAACAGTGGCCGTCGCATTGTTGTCCCGGCTGCCATGAACGATCACCACCACTGGCAGGGACAGGGTCTAAAAAGACACAAGAGAAGGCTGAGCGCCCACGAGCCTCAAGTTCTTCTCCTTCTCTCTTTTTTTTTTTTCTTATTATAACAACACTTTTATTTTCCAAGTTTCAGTTAATGTTCCTCTCAGACACAGAATCTAAATGGCCCCAGGAATAATATGACTTTTCATACTGGCACAATCTTAGAAATTTTAAATATTTTACAAGCAATGTTGCTTAGATATTTCTGAAGGATAAAGTTTCTCAAAGTTACATGGAGAACAGGAGAGAGAAAAGACTATTGGAGATATTTCTGGGAAGAAAATACAAATAACAAATTTAAAACTTACCACAACCTTTACTCAAATTCATCCCAAGTAATGTTTCTCATATCCATTTTGTAGTCTACCTCTCCAGCTAGTTCAGTTCATTATTGTTTGTTCATGTTTTATTTTTTATTTTTTAATTTGTTGTTGTTGTTGAGACGGGGTCTCACAACCAGCTCCAGGCTGGTCTGGAACTCCTGAACTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGATTACAGATGTGAGCCACTGCACTGGGCCTTGCTTGTTCATGTCTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTCTTTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGTTCATTACAACCTCAGCCTCCCAGGTTCAAGTGATTCTCCTGAGTAGCTGGGATTATAGGCACGTGCCACCACGCCTGGCTAATTTTTGTACTTTTTAGTAGAGATGGGGTTTCACTGTGTTAGCCAGGCTGGTCTTGAACTCTTGACCTCAAGTGACCTGACTGCCTCAACCTACCAAAGTGCTGGGATTACAAGCATGAGCCACTGTGCTTGGCCTCTGTTCATGTCTTAAGAGAACCTAAGTGAAACAGTTCTCAGGGTGAGGTCAGTCCATTTTCAGTTTACCAACAGTCAAAAAGAAGAAGATGCTATGTGATAAAAAAAAAATATTTTGTAACATAAAGTACACCACACACACACACGCACACGCACACGCAGAGCTGAGGGAAGGCTTTACCTTGACTTGAAAAACCAGCTCATTTCCACCAACACTGAACTGGGATTCAAACAGGATTGTAAATTTTTCTTCTGTCACCGACTCTGCCCCACGACGGTCTGACCTCTTAATTCGTTTCAGGGACTACAAAGAAGAAACATAAGATGAAACGTAAGATATAAGTTGTTCCCCTCAAAGACCAGGGAAAAATTCATTCTTCCTCTTCTTCCACCCTCACCATATTCCTGAAGTGGGCACTAAGGGTGCCTGTGGCTTGGTGGTACTCCATGACGCAGCAGTTGTTCAAGATCTCGCCACTGTAATCACTGCAAATCAGAGAGAGACCAGCTCCAAACCCATGCCAGGGTCTCAGGACATGCGGAGTAAATAATATAATTTGGGGTAGCAGGAAATAGAGAAGTTTGCTAAAAATGTACGTCATTTAGAGGAAATGTTAGCTACATAACACATACATGTAATCTTCTCGGACGTATCTCTACAAAATGAAACAAGATCAAACTATCTTCACAGAAAACAGTTCCTAAGAGAACTTTTTTTTTTTTTTTTGTGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAGTGGCGTGATCTCAGCTCACTGCAATCTCAGCTCACTGCAATCTCTGCCTCCCAGGTTCAAGGGATTCTCCTGCCTCAGGCTCTCTAGTGGCTGGGATTACAGGTGCCTGCCACCACGCCCGGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCTGCCCACCTCGGCCTCTTAAAGTGCTTGGATTACAGGTGTGAGCCACCACACCAGGCCCAAGAACTTCCTTATATTCCTTTGCTGATGCCCAGAAGAGGCCAGAAGGGCAAACAGGGATCTGACACAGGAGGCAGAATTCTTTTTTTCCTGTTGCCAGGACATGAG
Task1_train_24355
A variant was discovered on Chromosome 17, affecting STAT5B (signal transducer and activator of transcription 5B). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Growth hormone insensitivity with immune dysregulation 1, autosomal recessive
GCTTTTGGGAAGGAGGCCAGGGAGACGGGAAGCAATTTCCCTACTCCACTGGAGGCAGCTGAGCCTTCCCTGGCAAAAGCAGATCAATAGTCTGTGTTTCTGCTGAGTGAACTTGACAAATGGGACTGAGAAGACACTGCGTGATAGATCCAAACCCAACCTGAATCCAAACCTAATCCGCCACCATGCACAGGAAACAGAAAAGCCAGGCACGGGATCAGAAATACTGTTGACAGTCTAAGGACTTGGGTAGGAATAGCCATCCCAAATCTTCCGTTTCCATTCTCTGAAGGAGCTGCCCTTCTTCTAGGGCCAGTCTAGGATGGATTCAGATAAAAAAGGAAGACAGGCTAGAATCATCCTGTCAACCTTTACTCAATAACTGTTATGTTTCAGGCATTGTGCTGGCCTCAGGGTACAGAGATAAAAGATATAGTCCCTTCTCAAAGATTTATATTCCAGTGGAGAAGATAAAGAGTAAATAAGTAGTATCACTATAGACATAAAATGGAACCTACATACATGGAATTAGAGGAGCATGTGCTGTGTGTGTGTGTGTGTGCTGTGTGTCTATGTGTGTGTGGTGTGTATGTGTGGTGTGTGTGTGTGCTATGTGTGGTGTGTGTGTGCTGTGTGTGGTGTGGTGTGTGTGTGCTGTGTGTGGTGTGGTGTGTGTGGTGTGGTGTGTGTGTGCTGTGTGTCTGTGTGTGTGCTGTGTGTGGTGTGTGTGTGCTGTGTGTGTGCACTGTGTGTCTCTGTGTGCTGTGGGGGGTGTGTGTGCTGTGTGTGTGTGTGCTGTGTGTGTGATGTGTGTGGTGTGTGTGTGTGCTGTGTTGTCTGTGTGTGCTGTGTGTGTGTGTGTTTGGAGGGGCTGGGTGGTTGAGCCAAGGCTTCTCTGAGACTGAGCTGGGCATGGAAGCAGAGAGGAAACTATTAAAGCTCAAACTGCCAAACTGCTACAGGGTCAAAAGGGGGCGCTGGTGGGGCTCCACAGCCTCACCACAGACTGAAGCTCTCTGTGCCCCAACTACTAAGCAGGATTTATACCAGGCTAGGGAAGCTCTGTCCATAAGGGCTACCTAAGGGGCGTTAAGTGTACTCTGTTTCAGGAAGACCTCTGTGAATAACTGCATAGAACATTAGAAATCATATACAGGTCCTTAGTACTTACACGTACCTGCTTAGAAAGGTTTCTTTTCCCCCTTAGAGATAGGGTCTTACTATGTTGCCTAAGCTAGTCTGAAACTACTGGCCTCAAGTGATCCTCCTGCCCTGGCCTCCCAAAGCACCAGGATTACAGGTGTGCAAAACCACTCCCAGCTTAGAATTTTTTTTTTTTTTTTTTGAGACAGAATTTTGCTCTTTTTGTCCAGGCTGGAGTGCAATGGTGAGATCTCGGCTCCCTGCAACCTCCGCCTCCCGGGTTCAAGAGATTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATTACATGCATGCGCCACTGGGATGCCCAGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCAGAAAAATTTTTAAACATGTAATTATATAATTTCCTATTTATCATTTCAATAAAGCTCCACTTATAATATGCCTACTATATACAAAAGTATTGTTTGCTAGTATTTATTTAGACTGTGAGCTCCTTCTCAAAAGAAGAAATGTCTTCCCTGGCAGCTCAGAAGCTCCCTGGATGTGGGGACCTGAGTGAGATATGCACTTAAGCGGGGGGTCCTGTCATCTCCCCTTCCTAAATCTCATCCTCTCAGCACTGTCTTCAATGCAAATAAGTCCCTGCTACTCAGAGAAAGGTCGCTGCCTCCGAATGGAAAGTGTGCTTTCTCCCAACCCCACCAGAGCTGCTTTCCAGTCCCCAGGCCCAATCCTCAAGTTGCACAATGTGCCTCCACCGCGCCTCACCTTGGATCCTCAGGCTCTCCTGGTACTGGATGATGAAGTACTCCTGAGTCTGCTGCAGCTTTTTTAACTCATTCTCTGTGTCCTGCGTGACCAGTCGCAGCTCCTCAAACGTCTGGTTGATCTGGAGGTGTTTCTGGGACATGGCATCAGCAAGGCTTCCAGCTGGAGAGCTACCCTGGGAACATATGGGGGGCAGTGCAAGGCAGTGCGAATGGGAGGAAGACTGAGGCCTTAATCCCCAGGAAAAGCCAGCTCCTACAACCAGGGTAAGACCCCAAAAGGTAAATTTTGAGTCGGGAGGAAAAGCAAACGTCATCATGAGACACAGGGTGGAGTGGGAAAAGTGAGAAACAGGTGAGCGGACAGATCATGGCTCAGATCACAAAGCATGGGAGAAGCTTCCATTTCAGATCTGACCTCCACCAGAGTATTCCAAACGAGGTCCATTGAATTACCTTTGGAGAAACTAGAACGTAACCTGGTCCAGTGTCACCTGGGTTTTCCTACTAATGAGGAGGTGGAGTGATTCCTCTTCCACTCACTGACCCAATGCAAGGACGGCATTAAGCATTAGGGAGGCCATGGGGAGCAGGGCCATGTGAACACACATCATCTGTGTCCTCACTCAAGATATTCTCGTGATGGAATCATTTGCTTCCACCATGGAAGAGGCCAAACCTCTTGCAGGCATCCTGGAGACCCCAGGGTGAAGTGATGGGGGAGGCATAAACAAGGTCTCTGTGGACCCAGCCCTGTAAGTGACCTGATCAGACCACTCCTTCCACACCTGATTCAGGGGCTAGGGAAAAGTCTTTCCTAAGTATTCTCACCTGAATATGAGCATGCCTTTACTAAAAAATTATTCAGCTGAGGTTGAATTACTTTGCACTTGTTCACATTGTCTTGTGGTTGCAATCTCATCAAGGTTATAAATCAGTTAAGATCAGAGACCACATCTTCTATTTCATTTTTTTTTTTTTGAGACAGGGTCTCACTCCATCACCCATGAGTGCAGGGGTGCGATCATGGCTCACTGCAGCCTCTACCTCCTGGGCTCAAGGGATCTTCCCACTTCAGGTTTTCGAACAGCCAGGACTACAGGCATATGCCACCATGCCCAGCTAATTTTTTTGTATTTTTGGTAGAGACGGGGTTTCATCATGTTGCCCAGGGTGCTCTCGAACTCCTGGGCTCAGGCAATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGCTGCACTCAGTCAAGTCTCCTATTTCTTTTGTGCCCCTTAGGATGAAGCTCTCTTTAAAGAGACACCAATAGTGCACCCTGAGTCACCTTGACAAAGGTGGGTCCAGAGGGAGGTGGGTAAGAAAAGACTTCCCGACTGCCCTCCCCATCCCTATGGGACACTCACATTGTTGGCTTCTCGGACCAACCTCTGTTCATTGTACAATATATGGCGGATGCAGCGGACCAGCTCCATGGGGCAGCGGTCATACGTGTTCTGAAAGAATCCAACAGCAGACATCACTTTGTGCCACTCCACACTATGGGCCCTAACCATGCCTCAGGATGGGGAGCCTCCTGAGGGACCTCCTGAATCACAGGAGGCACTGTTCCTCCAATACCAACAGGAACAAGAAGGCACATCATGGAAATCCAATTGCAGTGAAAAGGTAAGATTGTTTTACTTCTTTTTTCTTTTTTTGAGACTGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAACCTCGGGCCACTGCAACCTCTGCCTCCTGGGTTCAAGTAATTCTCCTGCCTTAGCCCCCCGAGTAGCTGGGATTACAGGGGCCCGCCACCACGCCTGGCTAATTTTTGTCTTTTTAGTAGAGATGGGGTTCCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTTAGCCTCCCAAAGTGCTGTTTTACTTTTTGCATCTTAATTTGCCTAAAGTATCCGGGGAACATTCTTAAAAACGGAATAAATAAGTTTTAAAAGCCTCGCAAGAGGAGAAACTGGATGCCACTCTCAAATGGGCAATCAAAACT
GCTTTTGGGAAGGAGGCCAGGGAGACGGGAAGCAATTTCCCTACTCCACTGGAGGCAGCTGAGCCTTCCCTGGCAAAAGCAGATCAATAGTCTGTGTTTCTGCTGAGTGAACTTGACAAATGGGACTGAGAAGACACTGCGTGATAGATCCAAACCCAACCTGAATCCAAACCTAATCCGCCACCATGCACAGGAAACAGAAAAGCCAGGCACGGGATCAGAAATACTGTTGACAGTCTAAGGACTTGGGTAGGAATAGCCATCCCAAATCTTCCGTTTCCATTCTCTGAAGGAGCTGCCCTTCTTCTAGGGCCAGTCTAGGATGGATTCAGATAAAAAAGGAAGACAGGCTAGAATCATCCTGTCAACCTTTACTCAATAACTGTTATGTTTCAGGCATTGTGCTGGCCTCAGGGTACAGAGATAAAAGATATAGTCCCTTCTCAAAGATTTATATTCCAGTGGAGAAGATAAAGAGTAAATAAGTAGTATCACTATAGACATAAAATGGAACCTACATACATGGAATTAGAGGAGCATGTGCTGTGTGTGTGTGTGTGTGCTGTGTGTCTATGTGTGTGTGGTGTGTATGTGTGGTGTGTGTGTGTGCTATGTGTGGTGTGTGTGTGCTGTGTGTGGTGTGGTGTGTGTGTGCTGTGTGTGGTGTGGTGTGTGTGGTGTGGTGTGTGTGTGCTGTGTGTCTGTGTGTGTGCTGTGTGTGGTGTGTGTGTGCTGTGTGTGTGCACTGTGTGTCTCTGTGTGCTGTGGGGGGTGTGTGTGCTGTGTGTGTGTGTGCTGTGTGTGTGATGTGTGTGGTGTGTGTGTGTGCTGTGTTGTCTGTGTGTGCTGTGTGTGTGTGTGTTTGGAGGGGCTGGGTGGTTGAGCCAAGGCTTCTCTGAGACTGAGCTGGGCATGGAAGCAGAGAGGAAACTATTAAAGCTCAAACTGCCAAACTGCTACAGGGTCAAAAGGGGGCGCTGGTGGGGCTCCACAGCCTCACCACAGACTGAAGCTCTCTGTGCCCCAACTACTAAGCAGGATTTATACCAGGCTAGGGAAGCTCTGTCCATAAGGGCTACCTAAGGGGCGTTAAGTGTACTCTGTTTCAGGAAGACCTCTGTGAATAACTGCATAGAACATTAGAAATCATATACAGGTCCTTAGTACTTACACGTACCTGCTTAGAAAGGTTTCTTTTCCCCCTTAGAGATAGGGTCTTACTATGTTGCCTAAGCTAGTCTGAAACTACTGGCCTCAAGTGATCCTCCTGCCCTGGCCTCCCAAAGCACCAGGATTACAGGTGTGCAAAACCACTCCCAGCTTAGAATTTTTTTTTTTTTTTTTTGAGACAGAATTTTGCTCTTTTTGTCCAGGCTGGAGTGCAATGGTGAGATCTCGGCTCCCTGCAACCTCCGCCTCCCGGGTTCAAGAGATTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATTACATGCATGCGCCACTGGGATGCCCAGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCAGAAAAATTTTTAAACATGTAATTATATAATTTCCTATTTATCATTTCAATAAAGCTCCACTTATAATATGCCTACTATATACAAAAGTATTGTTTGCTAGTATTTATTTAGACTGTGAGCTCCTTCTCAAAAGAAGAAATGTCTTCCCTGGCAGCTCAGAAGCTCCCTGGATGTGGGGACCTGAGTGAGATATGCACTTAAGCGGGGGGTCCTGTCATCTCCCCTTCCTAAATCTCATCCTCTCAGCACTGTCTTCAATGCAAATAAGTCCCTGCTACTCAGAGAAAGGTCGCTGCCTCCGAATGGAAAGTGTGCTTTCTCCCAACCCCACCAGAGCTGCTTTCCAGTCCCCAGGCCCAATCCTCAAGTTGCACAATGTGCCTCCACCGCGCCTCACCTTGGATCCTCAGGCTCTCCGGGTACTGGATGATGAAGTACTCCTGAGTCTGCTGCAGCTTTTTTAACTCATTCTCTGTGTCCTGCGTGACCAGTCGCAGCTCCTCAAACGTCTGGTTGATCTGGAGGTGTTTCTGGGACATGGCATCAGCAAGGCTTCCAGCTGGAGAGCTACCCTGGGAACATATGGGGGGCAGTGCAAGGCAGTGCGAATGGGAGGAAGACTGAGGCCTTAATCCCCAGGAAAAGCCAGCTCCTACAACCAGGGTAAGACCCCAAAAGGTAAATTTTGAGTCGGGAGGAAAAGCAAACGTCATCATGAGACACAGGGTGGAGTGGGAAAAGTGAGAAACAGGTGAGCGGACAGATCATGGCTCAGATCACAAAGCATGGGAGAAGCTTCCATTTCAGATCTGACCTCCACCAGAGTATTCCAAACGAGGTCCATTGAATTACCTTTGGAGAAACTAGAACGTAACCTGGTCCAGTGTCACCTGGGTTTTCCTACTAATGAGGAGGTGGAGTGATTCCTCTTCCACTCACTGACCCAATGCAAGGACGGCATTAAGCATTAGGGAGGCCATGGGGAGCAGGGCCATGTGAACACACATCATCTGTGTCCTCACTCAAGATATTCTCGTGATGGAATCATTTGCTTCCACCATGGAAGAGGCCAAACCTCTTGCAGGCATCCTGGAGACCCCAGGGTGAAGTGATGGGGGAGGCATAAACAAGGTCTCTGTGGACCCAGCCCTGTAAGTGACCTGATCAGACCACTCCTTCCACACCTGATTCAGGGGCTAGGGAAAAGTCTTTCCTAAGTATTCTCACCTGAATATGAGCATGCCTTTACTAAAAAATTATTCAGCTGAGGTTGAATTACTTTGCACTTGTTCACATTGTCTTGTGGTTGCAATCTCATCAAGGTTATAAATCAGTTAAGATCAGAGACCACATCTTCTATTTCATTTTTTTTTTTTTGAGACAGGGTCTCACTCCATCACCCATGAGTGCAGGGGTGCGATCATGGCTCACTGCAGCCTCTACCTCCTGGGCTCAAGGGATCTTCCCACTTCAGGTTTTCGAACAGCCAGGACTACAGGCATATGCCACCATGCCCAGCTAATTTTTTTGTATTTTTGGTAGAGACGGGGTTTCATCATGTTGCCCAGGGTGCTCTCGAACTCCTGGGCTCAGGCAATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGCTGCACTCAGTCAAGTCTCCTATTTCTTTTGTGCCCCTTAGGATGAAGCTCTCTTTAAAGAGACACCAATAGTGCACCCTGAGTCACCTTGACAAAGGTGGGTCCAGAGGGAGGTGGGTAAGAAAAGACTTCCCGACTGCCCTCCCCATCCCTATGGGACACTCACATTGTTGGCTTCTCGGACCAACCTCTGTTCATTGTACAATATATGGCGGATGCAGCGGACCAGCTCCATGGGGCAGCGGTCATACGTGTTCTGAAAGAATCCAACAGCAGACATCACTTTGTGCCACTCCACACTATGGGCCCTAACCATGCCTCAGGATGGGGAGCCTCCTGAGGGACCTCCTGAATCACAGGAGGCACTGTTCCTCCAATACCAACAGGAACAAGAAGGCACATCATGGAAATCCAATTGCAGTGAAAAGGTAAGATTGTTTTACTTCTTTTTTCTTTTTTTGAGACTGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAACCTCGGGCCACTGCAACCTCTGCCTCCTGGGTTCAAGTAATTCTCCTGCCTTAGCCCCCCGAGTAGCTGGGATTACAGGGGCCCGCCACCACGCCTGGCTAATTTTTGTCTTTTTAGTAGAGATGGGGTTCCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTTAGCCTCCCAAAGTGCTGTTTTACTTTTTGCATCTTAATTTGCCTAAAGTATCCGGGGAACATTCTTAAAAACGGAATAAATAAGTTTTAAAAGCCTCGCAAGAGGAGAAACTGGATGCCACTCTCAAATGGGCAATCAAAACT
Task1_train_24356
This sequence variant lies in STAT5B (signal transducer and activator of transcription 5B) on Chromosome 17. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant
GCTTTTGGGAAGGAGGCCAGGGAGACGGGAAGCAATTTCCCTACTCCACTGGAGGCAGCTGAGCCTTCCCTGGCAAAAGCAGATCAATAGTCTGTGTTTCTGCTGAGTGAACTTGACAAATGGGACTGAGAAGACACTGCGTGATAGATCCAAACCCAACCTGAATCCAAACCTAATCCGCCACCATGCACAGGAAACAGAAAAGCCAGGCACGGGATCAGAAATACTGTTGACAGTCTAAGGACTTGGGTAGGAATAGCCATCCCAAATCTTCCGTTTCCATTCTCTGAAGGAGCTGCCCTTCTTCTAGGGCCAGTCTAGGATGGATTCAGATAAAAAAGGAAGACAGGCTAGAATCATCCTGTCAACCTTTACTCAATAACTGTTATGTTTCAGGCATTGTGCTGGCCTCAGGGTACAGAGATAAAAGATATAGTCCCTTCTCAAAGATTTATATTCCAGTGGAGAAGATAAAGAGTAAATAAGTAGTATCACTATAGACATAAAATGGAACCTACATACATGGAATTAGAGGAGCATGTGCTGTGTGTGTGTGTGTGTGCTGTGTGTCTATGTGTGTGTGGTGTGTATGTGTGGTGTGTGTGTGTGCTATGTGTGGTGTGTGTGTGCTGTGTGTGGTGTGGTGTGTGTGTGCTGTGTGTGGTGTGGTGTGTGTGGTGTGGTGTGTGTGTGCTGTGTGTCTGTGTGTGTGCTGTGTGTGGTGTGTGTGTGCTGTGTGTGTGCACTGTGTGTCTCTGTGTGCTGTGGGGGGTGTGTGTGCTGTGTGTGTGTGTGCTGTGTGTGTGATGTGTGTGGTGTGTGTGTGTGCTGTGTTGTCTGTGTGTGCTGTGTGTGTGTGTGTTTGGAGGGGCTGGGTGGTTGAGCCAAGGCTTCTCTGAGACTGAGCTGGGCATGGAAGCAGAGAGGAAACTATTAAAGCTCAAACTGCCAAACTGCTACAGGGTCAAAAGGGGGCGCTGGTGGGGCTCCACAGCCTCACCACAGACTGAAGCTCTCTGTGCCCCAACTACTAAGCAGGATTTATACCAGGCTAGGGAAGCTCTGTCCATAAGGGCTACCTAAGGGGCGTTAAGTGTACTCTGTTTCAGGAAGACCTCTGTGAATAACTGCATAGAACATTAGAAATCATATACAGGTCCTTAGTACTTACACGTACCTGCTTAGAAAGGTTTCTTTTCCCCCTTAGAGATAGGGTCTTACTATGTTGCCTAAGCTAGTCTGAAACTACTGGCCTCAAGTGATCCTCCTGCCCTGGCCTCCCAAAGCACCAGGATTACAGGTGTGCAAAACCACTCCCAGCTTAGAATTTTTTTTTTTTTTTTTTGAGACAGAATTTTGCTCTTTTTGTCCAGGCTGGAGTGCAATGGTGAGATCTCGGCTCCCTGCAACCTCCGCCTCCCGGGTTCAAGAGATTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATTACATGCATGCGCCACTGGGATGCCCAGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCAGAAAAATTTTTAAACATGTAATTATATAATTTCCTATTTATCATTTCAATAAAGCTCCACTTATAATATGCCTACTATATACAAAAGTATTGTTTGCTAGTATTTATTTAGACTGTGAGCTCCTTCTCAAAAGAAGAAATGTCTTCCCTGGCAGCTCAGAAGCTCCCTGGATGTGGGGACCTGAGTGAGATATGCACTTAAGCGGGGGGTCCTGTCATCTCCCCTTCCTAAATCTCATCCTCTCAGCACTGTCTTCAATGCAAATAAGTCCCTGCTACTCAGAGAAAGGTCGCTGCCTCCGAATGGAAAGTGTGCTTTCTCCCAACCCCACCAGAGCTGCTTTCCAGTCCCCAGGCCCAATCCTCAAGTTGCACAATGTGCCTCCACCGCGCCTCACCTTGGATCCTCAGGCTCTCCTGGTACTGGATGATGAAGTACTCCTGAGTCTGCTGCAGCTTTTTTAACTCATTCTCTGTGTCCTGCGTGACCAGTCGCAGCTCCTCAAACGTCTGGTTGATCTGGAGGTGTTTCTGGGACATGGCATCAGCAAGGCTTCCAGCTGGAGAGCTACCCTGGGAACATATGGGGGGCAGTGCAAGGCAGTGCGAATGGGAGGAAGACTGAGGCCTTAATCCCCAGGAAAAGCCAGCTCCTACAACCAGGGTAAGACCCCAAAAGGTAAATTTTGAGTCGGGAGGAAAAGCAAACGTCATCATGAGACACAGGGTGGAGTGGGAAAAGTGAGAAACAGGTGAGCGGACAGATCATGGCTCAGATCACAAAGCATGGGAGAAGCTTCCATTTCAGATCTGACCTCCACCAGAGTATTCCAAACGAGGTCCATTGAATTACCTTTGGAGAAACTAGAACGTAACCTGGTCCAGTGTCACCTGGGTTTTCCTACTAATGAGGAGGTGGAGTGATTCCTCTTCCACTCACTGACCCAATGCAAGGACGGCATTAAGCATTAGGGAGGCCATGGGGAGCAGGGCCATGTGAACACACATCATCTGTGTCCTCACTCAAGATATTCTCGTGATGGAATCATTTGCTTCCACCATGGAAGAGGCCAAACCTCTTGCAGGCATCCTGGAGACCCCAGGGTGAAGTGATGGGGGAGGCATAAACAAGGTCTCTGTGGACCCAGCCCTGTAAGTGACCTGATCAGACCACTCCTTCCACACCTGATTCAGGGGCTAGGGAAAAGTCTTTCCTAAGTATTCTCACCTGAATATGAGCATGCCTTTACTAAAAAATTATTCAGCTGAGGTTGAATTACTTTGCACTTGTTCACATTGTCTTGTGGTTGCAATCTCATCAAGGTTATAAATCAGTTAAGATCAGAGACCACATCTTCTATTTCATTTTTTTTTTTTTGAGACAGGGTCTCACTCCATCACCCATGAGTGCAGGGGTGCGATCATGGCTCACTGCAGCCTCTACCTCCTGGGCTCAAGGGATCTTCCCACTTCAGGTTTTCGAACAGCCAGGACTACAGGCATATGCCACCATGCCCAGCTAATTTTTTTGTATTTTTGGTAGAGACGGGGTTTCATCATGTTGCCCAGGGTGCTCTCGAACTCCTGGGCTCAGGCAATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGCTGCACTCAGTCAAGTCTCCTATTTCTTTTGTGCCCCTTAGGATGAAGCTCTCTTTAAAGAGACACCAATAGTGCACCCTGAGTCACCTTGACAAAGGTGGGTCCAGAGGGAGGTGGGTAAGAAAAGACTTCCCGACTGCCCTCCCCATCCCTATGGGACACTCACATTGTTGGCTTCTCGGACCAACCTCTGTTCATTGTACAATATATGGCGGATGCAGCGGACCAGCTCCATGGGGCAGCGGTCATACGTGTTCTGAAAGAATCCAACAGCAGACATCACTTTGTGCCACTCCACACTATGGGCCCTAACCATGCCTCAGGATGGGGAGCCTCCTGAGGGACCTCCTGAATCACAGGAGGCACTGTTCCTCCAATACCAACAGGAACAAGAAGGCACATCATGGAAATCCAATTGCAGTGAAAAGGTAAGATTGTTTTACTTCTTTTTTCTTTTTTTGAGACTGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAACCTCGGGCCACTGCAACCTCTGCCTCCTGGGTTCAAGTAATTCTCCTGCCTTAGCCCCCCGAGTAGCTGGGATTACAGGGGCCCGCCACCACGCCTGGCTAATTTTTGTCTTTTTAGTAGAGATGGGGTTCCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTTAGCCTCCCAAAGTGCTGTTTTACTTTTTGCATCTTAATTTGCCTAAAGTATCCGGGGAACATTCTTAAAAACGGAATAAATAAGTTTTAAAAGCCTCGCAAGAGGAGAAACTGGATGCCACTCTCAAATGGGCAATCAAAACT
GCTTTTGGGAAGGAGGCCAGGGAGACGGGAAGCAATTTCCCTACTCCACTGGAGGCAGCTGAGCCTTCCCTGGCAAAAGCAGATCAATAGTCTGTGTTTCTGCTGAGTGAACTTGACAAATGGGACTGAGAAGACACTGCGTGATAGATCCAAACCCAACCTGAATCCAAACCTAATCCGCCACCATGCACAGGAAACAGAAAAGCCAGGCACGGGATCAGAAATACTGTTGACAGTCTAAGGACTTGGGTAGGAATAGCCATCCCAAATCTTCCGTTTCCATTCTCTGAAGGAGCTGCCCTTCTTCTAGGGCCAGTCTAGGATGGATTCAGATAAAAAAGGAAGACAGGCTAGAATCATCCTGTCAACCTTTACTCAATAACTGTTATGTTTCAGGCATTGTGCTGGCCTCAGGGTACAGAGATAAAAGATATAGTCCCTTCTCAAAGATTTATATTCCAGTGGAGAAGATAAAGAGTAAATAAGTAGTATCACTATAGACATAAAATGGAACCTACATACATGGAATTAGAGGAGCATGTGCTGTGTGTGTGTGTGTGTGCTGTGTGTCTATGTGTGTGTGGTGTGTATGTGTGGTGTGTGTGTGTGCTATGTGTGGTGTGTGTGTGCTGTGTGTGGTGTGGTGTGTGTGTGCTGTGTGTGGTGTGGTGTGTGTGGTGTGGTGTGTGTGTGCTGTGTGTCTGTGTGTGTGCTGTGTGTGGTGTGTGTGTGCTGTGTGTGTGCACTGTGTGTCTCTGTGTGCTGTGGGGGGTGTGTGTGCTGTGTGTGTGTGTGCTGTGTGTGTGATGTGTGTGGTGTGTGTGTGTGCTGTGTTGTCTGTGTGTGCTGTGTGTGTGTGTGTTTGGAGGGGCTGGGTGGTTGAGCCAAGGCTTCTCTGAGACTGAGCTGGGCATGGAAGCAGAGAGGAAACTATTAAAGCTCAAACTGCCAAACTGCTACAGGGTCAAAAGGGGGCGCTGGTGGGGCTCCACAGCCTCACCACAGACTGAAGCTCTCTGTGCCCCAACTACTAAGCAGGATTTATACCAGGCTAGGGAAGCTCTGTCCATAAGGGCTACCTAAGGGGCGTTAAGTGTACTCTGTTTCAGGAAGACCTCTGTGAATAACTGCATAGAACATTAGAAATCATATACAGGTCCTTAGTACTTACACGTACCTGCTTAGAAAGGTTTCTTTTCCCCCTTAGAGATAGGGTCTTACTATGTTGCCTAAGCTAGTCTGAAACTACTGGCCTCAAGTGATCCTCCTGCCCTGGCCTCCCAAAGCACCAGGATTACAGGTGTGCAAAACCACTCCCAGCTTAGAATTTTTTTTTTTTTTTTTTGAGACAGAATTTTGCTCTTTTTGTCCAGGCTGGAGTGCAATGGTGAGATCTCGGCTCCCTGCAACCTCCGCCTCCCGGGTTCAAGAGATTCTCTTGCCTCAGCCTCCCAAGTAGCTGGGATTACATGCATGCGCCACTGGGATGCCCAGCTAATTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCAGAAAAATTTTTAAACATGTAATTATATAATTTCCTATTTATCATTTCAATAAAGCTCCACTTATAATATGCCTACTATATACAAAAGTATTGTTTGCTAGTATTTATTTAGACTGTGAGCTCCTTCTCAAAAGAAGAAATGTCTTCCCTGGCAGCTCAGAAGCTCCCTGGATGTGGGGACCTGAGTGAGATATGCACTTAAGCGGGGGGTCCTGTCATCTCCCCTTCCTAAATCTCATCCTCTCAGCACTGTCTTCAATGCAAATAAGTCCCTGCTACTCAGAGAAAGGTCGCTGCCTCCGAATGGAAAGTGTGCTTTCTCCCAACCCCACCAGAGCTGCTTTCCAGTCCCCAGGCCCAATCCTCAAGTTGCACAATGTGCCTCCACCGCGCCTCACCTTGGATCCTCAGGCTCTCCGGGTACTGGATGATGAAGTACTCCTGAGTCTGCTGCAGCTTTTTTAACTCATTCTCTGTGTCCTGCGTGACCAGTCGCAGCTCCTCAAACGTCTGGTTGATCTGGAGGTGTTTCTGGGACATGGCATCAGCAAGGCTTCCAGCTGGAGAGCTACCCTGGGAACATATGGGGGGCAGTGCAAGGCAGTGCGAATGGGAGGAAGACTGAGGCCTTAATCCCCAGGAAAAGCCAGCTCCTACAACCAGGGTAAGACCCCAAAAGGTAAATTTTGAGTCGGGAGGAAAAGCAAACGTCATCATGAGACACAGGGTGGAGTGGGAAAAGTGAGAAACAGGTGAGCGGACAGATCATGGCTCAGATCACAAAGCATGGGAGAAGCTTCCATTTCAGATCTGACCTCCACCAGAGTATTCCAAACGAGGTCCATTGAATTACCTTTGGAGAAACTAGAACGTAACCTGGTCCAGTGTCACCTGGGTTTTCCTACTAATGAGGAGGTGGAGTGATTCCTCTTCCACTCACTGACCCAATGCAAGGACGGCATTAAGCATTAGGGAGGCCATGGGGAGCAGGGCCATGTGAACACACATCATCTGTGTCCTCACTCAAGATATTCTCGTGATGGAATCATTTGCTTCCACCATGGAAGAGGCCAAACCTCTTGCAGGCATCCTGGAGACCCCAGGGTGAAGTGATGGGGGAGGCATAAACAAGGTCTCTGTGGACCCAGCCCTGTAAGTGACCTGATCAGACCACTCCTTCCACACCTGATTCAGGGGCTAGGGAAAAGTCTTTCCTAAGTATTCTCACCTGAATATGAGCATGCCTTTACTAAAAAATTATTCAGCTGAGGTTGAATTACTTTGCACTTGTTCACATTGTCTTGTGGTTGCAATCTCATCAAGGTTATAAATCAGTTAAGATCAGAGACCACATCTTCTATTTCATTTTTTTTTTTTTGAGACAGGGTCTCACTCCATCACCCATGAGTGCAGGGGTGCGATCATGGCTCACTGCAGCCTCTACCTCCTGGGCTCAAGGGATCTTCCCACTTCAGGTTTTCGAACAGCCAGGACTACAGGCATATGCCACCATGCCCAGCTAATTTTTTTGTATTTTTGGTAGAGACGGGGTTTCATCATGTTGCCCAGGGTGCTCTCGAACTCCTGGGCTCAGGCAATCTGCCTGCCTCAGCCTCCCAAAGTGCTGGGCTGCACTCAGTCAAGTCTCCTATTTCTTTTGTGCCCCTTAGGATGAAGCTCTCTTTAAAGAGACACCAATAGTGCACCCTGAGTCACCTTGACAAAGGTGGGTCCAGAGGGAGGTGGGTAAGAAAAGACTTCCCGACTGCCCTCCCCATCCCTATGGGACACTCACATTGTTGGCTTCTCGGACCAACCTCTGTTCATTGTACAATATATGGCGGATGCAGCGGACCAGCTCCATGGGGCAGCGGTCATACGTGTTCTGAAAGAATCCAACAGCAGACATCACTTTGTGCCACTCCACACTATGGGCCCTAACCATGCCTCAGGATGGGGAGCCTCCTGAGGGACCTCCTGAATCACAGGAGGCACTGTTCCTCCAATACCAACAGGAACAAGAAGGCACATCATGGAAATCCAATTGCAGTGAAAAGGTAAGATTGTTTTACTTCTTTTTTCTTTTTTTGAGACTGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGTGGCACAACCTCGGGCCACTGCAACCTCTGCCTCCTGGGTTCAAGTAATTCTCCTGCCTTAGCCCCCCGAGTAGCTGGGATTACAGGGGCCCGCCACCACGCCTGGCTAATTTTTGTCTTTTTAGTAGAGATGGGGTTCCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCACCTGCCTTAGCCTCCCAAAGTGCTGTTTTACTTTTTGCATCTTAATTTGCCTAAAGTATCCGGGGAACATTCTTAAAAACGGAATAAATAAGTTTTAAAAGCCTCGCAAGAGGAGAAACTGGATGCCACTCTCAAATGGGCAATCAAAACT
Task1_train_24357
Gene STAT3 (signal transducer and activator of transcription 3), found on Chromosome 17, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; STAT3-related early-onset multisystem autoimmune disease
CTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCAGACTGTCGCCCAGGATGGAGTGCAGTGTGCAGTGGTGCAATTTTGGCTCACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACACCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATT
CTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCAGACTGTCGCCCAGGATGGAGTGCAGTGTGCAGTGGTGCAATTTTGGCTCACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACACCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCATTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATT
Task1_train_24358
Here is a variant affecting STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; STAT3 gain of function
CTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCAGACTGTCGCCCAGGATGGAGTGCAGTGTGCAGTGGTGCAATTTTGGCTCACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACACCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATT
CTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCAGACTGTCGCCCAGGATGGAGTGCAGTGTGCAGTGGTGCAATTTTGGCTCACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACACCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCATTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATT
Task1_train_24359
Chromosome 17 houses a mutation in gene STAT3 (signal transducer and activator of transcription 3). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
CTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCAGACTGTCGCCCAGGATGGAGTGCAGTGTGCAGTGGTGCAATTTTGGCTCACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACACCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATT
CTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCAGACTGTCGCCCAGGATGGAGTGCAGTGTGCAGTGGTGCAATTTTGGCTCACTGCAACCTCCGCCTCTCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCGCCCACCACCACACCCAGCTAATTTTTTGTACTTTTAGTAGAGACGGGGTTTCACCGTGTTAGCCAGGATGGTCTTGATCTCCTGACCTTATGATCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCATTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATT
Task1_train_24360
With a mutation on Chromosome 17 in gene STAT3 (signal transducer and activator of transcription 3), classify this variant as benign or pathogenic. Include the disease if it's pathogenic.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
TGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACT
TGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTATCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACT
Task1_train_24361
Chromosome 17 houses a mutation in gene STAT3 (signal transducer and activator of transcription 3). Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?
Pathogenic; STAT3 gain of function
TGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACT
TGAGCCACCATGCCCGGCTGCTTAAGTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTATCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACT
Task1_train_24362
A variant has been detected on Chromosome 17 in STAT3 (signal transducer and activator of transcription 3). What is its effect — pathogenic or benign? If pathogenic, name the disease.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
GTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACTGTCAAAACAAAACAAAAACAAAAAC
GTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCATGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACTGTCAAAACAAAACAAAAACAAAAAC
Task1_train_24363
This variant lies on Chromosome 17 and affects the gene STAT3 (signal transducer and activator of transcription 3). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; STAT3 gain of function
GTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACTGTCAAAACAAAACAAAAACAAAAAC
GTTTCTTAAATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCATGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACTGTCAAAACAAAACAAAAACAAAAAC
Task1_train_24364
This variant affects the gene STAT3 (signal transducer and activator of transcription 3) found on Chromosome 17. What is the clinical effect of this variant — benign or pathogenic? State the disease if applicable.
Pathogenic; STAT3-related early-onset multisystem autoimmune disease
ATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGCAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACTGTCAAAACAAAACAAAAACAAAAACAAGGCTGGG
ATACAGAAAGGCTATGCTGATACAGTGTTTTTTGCCCTTTAATTGTTATTATTTCTTAATTTAAAAAGAAACCTAGGGCTTAGATAGTCCTATCTTCTATTTGGATGTCAGCAAGGTTAAAAAGTGCAATGCCAGGAGTATGTAGCTATAGGTGGCCTGTGGCATTTGCTTACAGAAACAGGCAGAAGGATGCCGCAGGCACCAGGAGGCACTTGTCTAAGAACAACAACAACAATAACAAAAAGCTGCTGAGAAAGGAGGGCAGGGGAACAAAACAACACAAGACATTTCCTTTTTCTCCCTCTAGCCACCCCCCGCCACATCCCCTGATCATGGGTCTCAGAGAACACATCCTTATTTGCATTTAGATAAAAGCAGATCACCCACATTCACTCATTTCTCTATTTTTAAAAGTGCCCAGATTGCTCAAAGATAGCAGAAGTAGGAGATTAAAAAAAATCTGGAACCACAAAGTTAGTAGTTTCAGATGATCTGGGGTTTGGCTGTGTGAGGGGTGGCAGAATGCAGGTAGGCGCCTCAGTCGTATCTTTCTGCAGCTTCCGTTCTCAGCTCCTCACATGGGGGAGGTAGCGCACTCCGAGGTCAACTCCATGTCAAAGGTGAGGGACTCTGGAGGGACAGACAGGGAAAACTAGTTCAGTTGTCCACCCTCTGCAACTGGCAGGCCACGCCCCCAGCCCTTCAGAGGACAGGGCCCAGGCTACCACTGCTATCCAATCTCCTGCCCCTTAAGGCCCAGGGATGGTCAGAAAAGCCAGATTTACCCTCCTCCCTGGAGGACCCTGCCTCGGGAAGGGTCCTTTCTCATTCCCACCTTAACTGATTCCCAGAGCTCCATGTTTACAGAAGCTCTAAGGCTGTCCTGAGATCTTCTGCCCTTGATCTACTGTTTAATTCAGGAGCCCCGAGACACACGTGGCCACCAAGCATTTGAGATTTGGTTTGTCCAAACTGAGCTGTGCTGTGGCTGTCAAAAGCCCACTGGATTTTAAAGGCTTAGTATGAAAAAAAAGAATAAAAAAAGGTCTCAACTTTTTCTTTTTAGTTTAGTTTTGTTTATTTGAGATGGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCGATCCTCCCACCTCAGCTTCTTGAGTAGCTGGGATTACAGGTATGCGCCACCATGCCCAGCTAATTTTTATATTTTAGAGATTTTGGTCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACTCACCCAGCCTCAACTTTTTCTGAAATGTTAAATTGAGAGTATGTTGGATTTAGTGGGTTAAATAAAATATATTGTAAAAATTAAGTTCGTCTATTTCCAGTGTGGCTGCTAGAAGATTTATACTCACACATGTGGCATTCATACCATCTCTTTTGGAAAGCAAAGCTCTAGAATCTCCTACCATTCCGAGTGACCAGCTCTCGGTGTGTACATGTGAGAGCATCACACAAAGGGGACCAACTTCCCTTATAGGGACAAAGTCTGTCAACCAAATACTCACCAAACTGCCCTCCTGCTGAGGGTTCAGCACCTTCACCATTATTTCCAAACTGCATCAATGAATCTAAAGTGCGGGGGGACATCGGCAGGTCAATGGTATTGCTGCAGGTCGTTCTGTAGGAAATGGGGGGCAGCAGGAGGGGAAACGGGGGGTTGACAAGACACAATGGAAAAAAAAAAAAGAACAAAACACACACACACAAGCCATCAAACTCTGGTCTCCAACAGAAAAATAAAAGCTCAAGCTTTTTAAACACACAAGGTCACTTTGAGTACTAAACATAGCCCAGGGGCTTCCAACCTTTGGCAGATTAACTCTCACCCAGTGTCCCATTCCCAGGGATAACTGAGGATATTAGAAATGAAGGCAAAACGGGGAAAGGAAGCCACTTACGGTGTCACACAGATAAACTTGGTCTTCAGGTATGGGGTAGCGCCTGGGAAGAAGAAAACCAGTTTTCTTACTGACTGTGACTTCGCATTCAGTAAGCAGAGCTGGAGGAAGCCATCTGCCTCGGCAGGACTGATTTGAAACTCACTCATCCTCATGCCAAGATTGTCTGGAAAGCTCCATCTGCCCCTCAGGGTTGTCTGCCCTCATTTATACTATTTGATCTCCCAGGCACTAGCAGCTGTGAACTTCAGTTCTTTGCACAAAGCTGTCCTGAGCTGCAGAGACTTTTCAGCATAACCTTTTCCCACCTGACCCTAGACTAATGCCACCTTGTGTCCCTTCTTTCCCTAGATTATGTAAAAGTTTAACAGCCTCCACGTGGTCTGAGCATTCTATTCCGGCCTGGTCATATCTCTTAGATAACTTCTCTGCATGCAGGAACCGAGCCTGTGTAGTCTTTGCATGGTGTCCAGCCTAAATACCAATATCACCAAGTCTTTAAAGAACATGGAGACTGCTAATGCTTGTGGTTCCAAAGCCAAAGGTTATATCTCTTATTCCTACCAGCACTAATCTGGCCTCTACCACATTTTTGGATGAGGGCATGAGTAACTTTCTAGTTGGATAAATACGTCAATCAAAAAGCACCAAAGAGAATGTGACTTTGTAAGGCAGTACAATTGCTTCAACTAGAAGACCGGAGACCTGGGTCCAGGTACATCTTCAATAGCTAAGAGACCTGGAGCAAGGCATGGTCTCTCTCTTTTGTTGCTGTTGTTCTTATTGTTTTGAGACAGAGTCTCACTCTGTTGCCCAGGCTCAAGTGCAGTGGCACAATCTCGGTTACCGCAACCTCCTACTCCCAGGTCAAAACGATTCTCCTGCCTTAGGCTCCCAAGCAGCTGGGACTACAGGTGGCACCACCATGCCTGGCTAATTTTTGTCTTTTTTTTTTTTGAGACGGAGTCTTGCTCTCTTTCGCCCAGGTTGGAGTGCAGTAGCGCCATCTTGGCTCTCTACAACCTCTGCCTCCAGGGTTCAAGTGATTCTCCTTCATCAGCCTCCTGAGTAGCTGGATTACAGGCATCTGCCACCATGCCTAGCTAATTTTTTTTTTGTAATTTTAGTAGAGATGAGGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCATCTGCCTCACCCTCCCAAAGTGCTGGATTACAAGTATGAGCTATCATGCCCAGCCTTGGCCACAATGCCCAGCCCATATTCTCTTTTATGTATAAAATAAGAGGGAGGGGGAAGACAAGGTGCCAATTTTCTATGAGCTTTGTCATTTATAATTCTTGTTCTACAGTTAGAAATGCGTTGACGGGAATAAAATGAATTTTAGATGCTGAATGCTTACACCAAGAGGTCAAGGAACCTTGGGGATACTGGCATGAAATCTGGGGAATTCAGGTGAACAAACCATTGAGAAGGCATGGGGCAGGGTGAGGTGGGCTGAGAACAGCACGGTCATAAAACATGAGGCTTAGACAGAACCTGAGGGATCAGAGAGCATGATGACCATGTGAAAGAAGGCACTGCAGAGTGGCTCTTGGGCTGCCATCTGAGTTTACTTTGGGCCAAGAAACTGATCAATTCAGTGCAGAATTCAAAGGAGCTACTGAGGCAAGACTCTAGTGTCTTATAAATCCAACTGTTTTGGCCCAGCCCTTAGGGAGCTGACACCCTAGACAGAAAAGGATTTAATTCTCCAGCATTCAAGATAGCTGAGGCCAGGCACAGTGGCTCATGCCTGTAATCCCTGCACTTTGGGAGGCTGAAGCAGGTGGATCACTTGAGGCCAGGAGTTCAAGACCAGCCTCACCAACATGGGGAAACCCTGTCTTTAATGAAATTACAAAAATAGCTGGGCGTGGTGGCACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTTGAACCTGGGAGGCAGAGGCTGAAGTGAGGTGAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGTGACAGACTGTCAAAACAAAACAAAAACAAAAACAAGGCTGGG
Task1_train_24365
This variant lies on Chromosome 17 and affects the gene STAT3 (signal transducer and activator of transcription 3). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; STAT3-related early-onset multisystem autoimmune disease
TGTGCTATTTGGACAAAAATAGTTTTTTCAACAGCAACTAGGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAG
TGTGCTATTTGGACAAAAATAGTTTTTTCAACAGCAACTAGGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATGTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAG
Task1_train_24366
Given this context: Chromosome 17, gene STAT3 (signal transducer and activator of transcription 3) — does this variant present pathogenic behavior, and if so, what disease does it relate to?
Pathogenic; STAT3-related early-onset multisystem autoimmune disease
ACTAGGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATC
ACTAGGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTCTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATC
Task1_train_24367
This variant affects gene STAT3 (signal transducer and activator of transcription 3) located on Chromosome 17. Evaluate its biological effect and specify any disease association.
Pathogenic; STAT3 gain of function
GGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACC
GGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCTGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACC
Task1_train_24368
This variant affects gene STAT3 (signal transducer and activator of transcription 3) located on Chromosome 17. Evaluate its biological effect and specify any disease association.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
GGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACC
GGGCAAGGCGCCAACCCTAAAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCTGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACC
Task1_train_24369
A variant found in Chromosome 17 affects STAT3 (signal transducer and activator of transcription 3). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
AAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATC
AAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGCTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATC
Task1_train_24370
A mutation on Chromosome 17 affecting STAT3 (signal transducer and activator of transcription 3) has been found. Is it harmful or harmless? What disease, if any, does it cause?
Pathogenic; STAT3 gain of function
AAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATC
AAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGCTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATC
Task1_train_24371
This variant lies on Chromosome 17 and affects the gene STAT3 (signal transducer and activator of transcription 3). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
AAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATC
AAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGTTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATC
Task1_train_24372
This mutation is located in gene STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Is it associated with a disease or is it a benign polymorphism?
Pathogenic; STAT3 gain of function
AAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATC
AAGGATCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGTTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATC
Task1_train_24373
The variant affects gene STAT3 (signal transducer and activator of transcription 3), which is on Chromosome 17. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
TCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTC
TCACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCGCGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTC
Task1_train_24374
This mutation occurs in STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Does this change lead to a known medical condition, or is it benign?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
CACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCG
CACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCATGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCG
Task1_train_24375
This variant impacts the gene STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Is the change likely to result in a pathogenic outcome?
Pathogenic; STAT3 gain of function
CACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCG
CACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCATGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCG
Task1_train_24376
A variant was discovered on Chromosome 17, affecting STAT3 (signal transducer and activator of transcription 3). What is its functional impact — neutral or pathogenic? State the disease if pathogenic.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
CACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCG
CACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCATGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCG
Task1_train_24377
Consider a variant on Chromosome 17 in gene STAT3 (signal transducer and activator of transcription 3). Determine its clinical classification and disease relevance.
Pathogenic; Hyper-IgE syndrome
CACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCG
CACATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCATGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCG
Task1_train_24378
Located on Chromosome 17, this mutation impacts STAT3 (signal transducer and activator of transcription 3). What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?
Pathogenic; STAT3 gain of function
CATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGAC
CATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGTACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGAC
Task1_train_24379
The following genetic variant occurs in STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
CATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGAC
CATTAAAGAGCCCATCATTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAAGTGGGCAGATCACCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAACATGGCGAAACCCTTTCTCTACAAAAAATACAAAAATCAGCTGGGCATGGTGGCACAAGCCCATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCGGGAGGTGGAGGTTGCAGTGAGCCGAGATGGTGCCACTGCACTCCAGCTTGGGTGATAGAGCAAGACTTAGTCTAAAAAAAAAAAAAAAAAAAAAGCCCATCATTGGCTTTATGATTACAGAAAGTTAAATCAAACAAAGAATGGCAAACCAGAGACTCCCCATCAAGACCTGCACAAAGAACCCAGAGAGTCAAAACAGCAAGTGCTGAAGGGGAACAGACAGGGCTACCCCCTCCACACTGAGGACAGCTGCAGAGATTACAGTTTTGTTTCGTTTTTTTCTTTCTCTTCTTTGTGTGTGTGTGTGTGTGTGTGTGTAGTGGGGTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGTACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGAC
Task1_train_24380
Here is a variant affecting STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Please identify whether it is a benign mutation or associated with a disorder.
Pathogenic; STAT3 gain of function
GTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGT
GTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAATGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGT
Task1_train_24381
Gene STAT3 (signal transducer and activator of transcription 3) on Chromosome 17 is impacted by this variant. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
GTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGT
GTCTTGCTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAATGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGT
Task1_train_24382
The variant affects gene STAT3 (signal transducer and activator of transcription 3), which is on Chromosome 17. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
CTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGAC
CTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAACTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGAC
Task1_train_24383
A genomic change on Chromosome 17 affects STAT3 (signal transducer and activator of transcription 3). Classify this variant as benign or pathogenic, and name the disease if relevant.
Pathogenic; STAT3 gain of function
CTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGAC
CTATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAACTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGAC
Task1_train_24384
A mutation in STAT3 (signal transducer and activator of transcription 3), located on Chromosome 17, is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
TATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACT
TATGTTGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGCGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACT
Task1_train_24385
Gene STAT3 (signal transducer and activator of transcription 3), found on Chromosome 17, is impacted by this variant. What is the biological outcome — benign or pathogenic?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
TGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCT
TGCCAGGCTGGTCTTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGTCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCT
Task1_train_24386
A mutation found in STAT3 (signal transducer and activator of transcription 3) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
TTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGG
TTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCCGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGG
Task1_train_24387
A mutation found in STAT3 (signal transducer and activator of transcription 3) on Chromosome 17 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?
Pathogenic; STAT3 gain of function
TTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGG
TTGAGTTCCTGGCCTCAAGTGATCCTCCTGCTTCAGCCTCCCAAAGTGCTAGGACTGCAGGTGTGAACCCCCATGCCCAGCTGAGATTACAGTATTTTTAATTTCTCTCTCTTTTTTTTTTTTTTTTTTTTGGTGAGTCAAGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGTGCGATCATGGCTCACTGCAGCCTCAACCTCCTGGGCTTAAGCAATCCTCCCACCTCAGCCTCCCGAGTAGCTAGGACTACAGGCACAAACCACCACACGTGGCTAATTTAAAAAAAATTATTTTTGTATAGATAGGGTCTCACTATGTTGTCTAGGCTGTTCTCAAACTCCCAGGCTCAAGTGATCCTCCCGCCTGGGCCTCCCAAAGTGCTAGGACTATAGGCATGAGCCACTTCACCCAGCTAAAATAATTTATATATAACATATAAGTACATGTCCTCTTACACATTAAAATATACCTTATTTTCAATAGTTGCACACTCTAAATACTAATCCCTTGCCCCTCCACCCAGTCACTGTCTTCCCCTTCAAACGTGATGCTCCCAGCTCTTCTACTCTAGTGTAAACCATACTCCCATGCAGCTAATAATAATTTCCTCCAGAAACCCTTTCTTCAGACCATCTGGCACACTGACATGGTTCAGTTACAGGCAAAAAGCCATATGCTGGGCTGAAATCTGGGCCTCAAACCTTCTAGCATCTACTAAGAAGCACTGTGCCAGCAGGGCATCCTGTTAACTGCCCTCACTTTCCCTTCTCGTGTTTCAGGCATGTTTTGGGGGACGTATGTGTATTGATCCCCTCTTTATTTTTATTTTTTGACACAGTATCTCACTCTATCAGCCAGGCTGGAGTGCGGTGGCATGATCACCGCTCACTACAGCCTTGAACTCCTTGGCTCAGGTGATCCTCCCACCTCAGCCTCCCAAGTAGCTACGACTACAAATGCGTGCCACCACACCGGGTAATTTTTTTGGATTTTTTGTAGAGACGAGGTTTCACCATATTGCCCAGGCTGTATCCCCTCTTTAGACTCATGCACTCTCTGTGGAGCAGGAACTACACTACTCTAAGTGATTCTGATTCTCCTCTCAAATCCCATCGGTCACCCCAACAAAAGCACTCACTACAATTCTTTCCCATAAGGAGAAATAATTATCCCCCAGGTTATTCAGGCATTTGCCTATCTATCCTCCAAGGATCCCAAAATTTCCAACTTTTCCCAAAAATTAAATGCCAGGAACATGGAAAATCAACAACTACCTGGGTCAGCTTCAGGATGCTCCTGGCTCTCTGGCCGACAATACTTTCCGAATGCCTCCTCCTTGGGAATGTCAGGATAGAGATAGACCAGTGGAGACACCAGGATATTGGTAGCATCCATGATCTTATAGCCCATGATGATTTCAGCAAATGACATGTTGTTCAGCTGCTGCTTTGTGTATGGTTCCACGGACTGGATCTGGGTCTTACCTGTCACAGGACATGGGAAGGAAAGATCATGGAACCTACAGCTAGGTCATCTCAGAGAAAACTGCCCATTTTTTCTTTCCTCGAAGGGGAAAAGACTTAAGCCACCCTAGTGTTGAGACCCTGAACACCCTGTTCAGTGGCCTGGCACTGTGGAAATATTCAGGCTGGCTTCTAATTAAGAAGAGGCTACTAGTTGGGTCATAGAAAATAAACTTGAATATAACTACTTGCGTAAGATATATTAACAGGGTTAAGTAGAAAAAGAGATGAAGAATACAATTTAAATTGCAAAATTCTCAACAAATAGTCACTGGAGCAAGCAAAACAAAGCAAACCAATCCTTCAGCTGGAAGGATTTAGAAGTCACGCAAATGTGTTTTGCGAGTCTGAGTGAAACAGGGAGTCAAGGCCATCTCCACCCACCAGGGGGCAGTAGGTGCTTGCAACTAGAAGCAGTGATGAGGCCTCAGCAGCCACCAGCAGGTGGGGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCCGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGG
Task1_train_24388
The following genetic variant occurs in STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Classify its clinical effect — pathogenic or benign — and list any associated condition.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
GGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGGGGCTCTCACAGCCTTGGAAATCTCTTCACCCGCATCTCACGGGGCTCAGAATGAAAGGACATGCCATAAACCACACCTGCTGCCAACTCTAGGCGAGGAGTGTGAGTGAGTCAGCTCAGTGAGCACTCATAGTGGAAAGAATGCCCAGCGTGGCCACACAACTCAGGCTGCAGTCGGAATATACCGGTCCCTTGTAAAACCTGACTTGCTCAAAGCTTGACTCACAATCCACAGATTCCCCATTTTTAAGACCTTGGAGGCATTCTCCAAGACTTGAAGCTGTATCTTCACATGAAACAGGGAGGTCTCAGGAATCAAAGACCAGGATTCCTGCTTTTCTAGGTATATCTTAATTTAAAAATCAAGAAAGTTGGGAAAGGAGAATGTCATTGCCACAATTTTCTGTATACTAAACACACTGGCTGCTAAGACTCTTATGCCCAAACTTTATAAAGTCAGTTCTAATTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAATGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGTCCGCCACCATACCCAGCTAATTTTTGTATTTTAGTAGAGACGGGGTTTCGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCAATCAATTTCTAAATAGAGATTTTCATATCAAGTTTGCTGAAAGCTGAATATACACACATCTTCTAAGCATTCAAGCAAGACTTTATTGCCAGATGGGATGCCAAGGATTTTTTTGGAGAAAAGTAAGCAAAAATAAACACAGTGTTAAGCAAACAGTAATCATTCCACCTTCTCTTGTAAAAATCCCAGTGGAAGTTTTTGTCCTGAGTCACCCCTGTACGTAGCCTCTCACCGATTCTGCTGCAGAACTTACCTCTAGGTCAATCTTGAGGCCTTGGTGATACACCTCGGTCTCAAAGGTGATCAGGTGCAGCTCCTCAGTCACAATCAGGGAAGCCTACAGTAACGAGAAGGACACTCTTAGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATTGCCTGAGCCCAGGAGTTCGAGACCAGTCTAAGCAGCACAGCAAAACTCCATCTCTGCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTATAGCCCCAGCTACTCGAGAGGCTGAGGTGGGAGGATGGCTTGAGCCTAGGAGATGGAGGCTGCAGCGAGCTATGATTGTGCCACTGCACTCTAGCTGGGGTGACAGAGTGAGACCCTGTCTTAAAAAAAAATTAAATTAAATAAAAAAAAAGGCTGAGCGTGATGGCTCACACCTACAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACATGGTCAGGAGTTCGAGACCAGCCTGGCCAATAATTTGGTGAAACCCCGTTTCTACTAAGAATACAAAAATTAGCTGGGTGTGGTAGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAATCAATCAGTCAATCAATAAAAAAGAGAAGGACACTTTTCCTCAGAGAGAATGGCATTCAGTACTAACAGCCACAGCCAAGGAAAGTGACATGCCAAGCCTCACCACACCAAGAAGGGTAAGCCACCAGGTGGTCACAAACAAACTGCCAGGGACACAACTTGCTCGGCACTTACTCTCTTCAACACCAAGAACTTCCAATGCTGTGATCCTCAACCTAATCCTTTACTCAGTTTGTATTATAATATTACATAGATC
GGTGGGTGGGAGCCTCCCTTACCGCTGATGTCCTTCTCCACCCAAGTGAAAGTGACGCCTCCTTCTTTGCTGCTTTCACTGAATCTTAGCAGGAAGGTGCCTGGAGGCTTAGTGCTCAAGATGGCCCGCTCCCGCTCCTTACTGATAAAGCCCATGATGTACCTGGAGCCAAGGAGGAGGAACAATGTTGTTATTGCTAACAGGGCATCCATCCCCTGCCACTGGCTTGCTGAGAGCAGGGGACTTGGTTACATCTGTGCACACTCTGTCCAACCTACCCTTCGTTCCAAAGGGCCAGGATGTACTTTTTCACAAGGTCAATGATATTGTCCAGCCAGACCCAGAAGGAGAAGCCCTTGCCAGCCATGTTTTCCTGGAGAAAAGAGTAATGGGAAAGCCAAGTCTACTGCCATCCCAGCCCTTCCCTTCCTAGGGGTGCAGTGCATCACCCAAATCCTCAGGCCCGTCTACCTTCAGGCAGGTCCTACTGGCCGCTGGACCAAGAGTTCAGGGCCTTCAAGCCAGAGCCCTCAACGACAGCCGTGCAGGTGAGCATTCCCATTCCCACGAGAATTTAACAAGATTGCTTACTTTGCAAAATTTAGCCCATGTGATCTGACACCCTGAATAATTCACACCAGGTCCTGAAGGAAAGAAAAAGAGTCAAGTAGTACATTTTCAGCTTGGGGTCAAGAGGTTATTTCTTAAAACAGAACACACACACATTCATCCCACAATGGGCCACAAAATAATCAGCTTTCACATCTTTGAAGGTAGGCACTGTTGTGTGTGTGCACATGAGGACAAACACTATCCCATCATTTGACTCACTTGTGTTGCTGGGTAGCCCAGCAGGGATGGAGGGTGATATAACAAGTCCCCCTGCTCTTCCCAACCTCGGGTGGTAGGCTGGGAACCAACAGCAGCACTCACTAACAAGCTGACATCGGGTGTCAGACAGGTGTATTTGGTGGCAACAGCTTTATTAGAACAAAGCTACTTCTAGCCCAGGTGGCACATAAAATATTCCACTAATTCTTTTTTAAAAACTAGCCTACGCTGGGCACAGTGGCTCAAGCCTGTAATCCCAGCACTTTAGGAGGCCGAGGTGGGCGGATCACGAGGTGAAGAGACGGAGACTATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGCTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGGGGCTCTCACAGCCTTGGAAATCTCTTCACCCGCATCTCACGGGGCTCAGAATGAAAGGACATGCCATAAACCACACCTGCTGCCAACTCTAGGCGAGGAGTGTGAGTGAGTCAGCTCAGTGAGCACTCATAGTGGAAAGAATGCCCAGCGTGGCCACACAACTCAGGCTGCAGTCGGAATATACCGGTCCCTTGTAAAACCTGACTTGCTCAAAGCTTGACTCACAATCCACAGATTCCCCATTTTTAAGACCTTGGAGGCATTCTCCAAGACTTGAAGCTGTATCTTCACATGAAACAGGGAGGTCTCAGGAATCAAAGACCAGGATTCCTGCTTTTCTAGGTATATCTTAATTTAAAAATCAAGAAAGTTGGGAAAGGAGAATGTCATTGCCACAATTTTCTGTATACTAAACACACTGGCTGCTAAGACTCTTATGCCCAAACTTTATAAAGTCAGTTCTAATTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAATGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGTCCGCCACCATACCCAGCTAATTTTTGTATTTTAGTAGAGACGGGGTTTCGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCAATCAATTTCTAAATAGAGATTTTCATATCAAGTTTGCTGAAAGCTGAATATACACACATCTTCTAAGCATTCAAGCAAGACTTTATTGCCAGATGGGATGCCAAGGATTTTTTTGGAGAAAAGTAAGCAAAAATAAACACAGTGTTAAGCAAACAGTAATCATTCCACCTTCTCTTGTAAAAATCCCAGTGGAAGTTTTTGTCCTGAGTCACCCCTGTACGTAGCCTCTCACCGATTCTGCTGCAGAACTTACCTCTAGGTCAATCTTGAGGCCTTGGTGATACACCTCGGTCTCAAAGGTGATCAGGTGCAGCTCCTCAGTCACAATCAGGGAAGCCTACAGTAACGAGAAGGACACTCTTAGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATTGCCTGAGCCCAGGAGTTCGAGACCAGTCTAAGCAGCACAGCAAAACTCCATCTCTGCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTATAGCCCCAGCTACTCGAGAGGCTGAGGTGGGAGGATGGCTTGAGCCTAGGAGATGGAGGCTGCAGCGAGCTATGATTGTGCCACTGCACTCTAGCTGGGGTGACAGAGTGAGACCCTGTCTTAAAAAAAAATTAAATTAAATAAAAAAAAAGGCTGAGCGTGATGGCTCACACCTACAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACATGGTCAGGAGTTCGAGACCAGCCTGGCCAATAATTTGGTGAAACCCCGTTTCTACTAAGAATACAAAAATTAGCTGGGTGTGGTAGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAATCAATCAGTCAATCAATAAAAAAGAGAAGGACACTTTTCCTCAGAGAGAATGGCATTCAGTACTAACAGCCACAGCCAAGGAAAGTGACATGCCAAGCCTCACCACACCAAGAAGGGTAAGCCACCAGGTGGTCACAAACAAACTGCCAGGGACACAACTTGCTCGGCACTTACTCTCTTCAACACCAAGAACTTCCAATGCTGTGATCCTCAACCTAATCCTTTACTCAGTTTGTATTATAATATTACATAGATC
Task1_train_24389
This variant impacts the gene STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Is the change likely to result in a pathogenic outcome?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
TATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGGGGCTCTCACAGCCTTGGAAATCTCTTCACCCGCATCTCACGGGGCTCAGAATGAAAGGACATGCCATAAACCACACCTGCTGCCAACTCTAGGCGAGGAGTGTGAGTGAGTCAGCTCAGTGAGCACTCATAGTGGAAAGAATGCCCAGCGTGGCCACACAACTCAGGCTGCAGTCGGAATATACCGGTCCCTTGTAAAACCTGACTTGCTCAAAGCTTGACTCACAATCCACAGATTCCCCATTTTTAAGACCTTGGAGGCATTCTCCAAGACTTGAAGCTGTATCTTCACATGAAACAGGGAGGTCTCAGGAATCAAAGACCAGGATTCCTGCTTTTCTAGGTATATCTTAATTTAAAAATCAAGAAAGTTGGGAAAGGAGAATGTCATTGCCACAATTTTCTGTATACTAAACACACTGGCTGCTAAGACTCTTATGCCCAAACTTTATAAAGTCAGTTCTAATTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAATGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGTCCGCCACCATACCCAGCTAATTTTTGTATTTTAGTAGAGACGGGGTTTCGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCAATCAATTTCTAAATAGAGATTTTCATATCAAGTTTGCTGAAAGCTGAATATACACACATCTTCTAAGCATTCAAGCAAGACTTTATTGCCAGATGGGATGCCAAGGATTTTTTTGGAGAAAAGTAAGCAAAAATAAACACAGTGTTAAGCAAACAGTAATCATTCCACCTTCTCTTGTAAAAATCCCAGTGGAAGTTTTTGTCCTGAGTCACCCCTGTACGTAGCCTCTCACCGATTCTGCTGCAGAACTTACCTCTAGGTCAATCTTGAGGCCTTGGTGATACACCTCGGTCTCAAAGGTGATCAGGTGCAGCTCCTCAGTCACAATCAGGGAAGCCTACAGTAACGAGAAGGACACTCTTAGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATTGCCTGAGCCCAGGAGTTCGAGACCAGTCTAAGCAGCACAGCAAAACTCCATCTCTGCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTATAGCCCCAGCTACTCGAGAGGCTGAGGTGGGAGGATGGCTTGAGCCTAGGAGATGGAGGCTGCAGCGAGCTATGATTGTGCCACTGCACTCTAGCTGGGGTGACAGAGTGAGACCCTGTCTTAAAAAAAAATTAAATTAAATAAAAAAAAAGGCTGAGCGTGATGGCTCACACCTACAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACATGGTCAGGAGTTCGAGACCAGCCTGGCCAATAATTTGGTGAAACCCCGTTTCTACTAAGAATACAAAAATTAGCTGGGTGTGGTAGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAATCAATCAGTCAATCAATAAAAAAGAGAAGGACACTTTTCCTCAGAGAGAATGGCATTCAGTACTAACAGCCACAGCCAAGGAAAGTGACATGCCAAGCCTCACCACACCAAGAAGGGTAAGCCACCAGGTGGTCACAAACAAACTGCCAGGGACACAACTTGCTCGGCACTTACTCTCTTCAACACCAAGAACTTCCAATGCTGTGATCCTCAACCTAATCCTTTACTCAGTTTGTATTATAATATTACATAGATCCAATTGGTTATTTGTAAAATACGTAAGGCACAAAGAATAACAAAACAATATGAACCCACCATTCAATTTAAGGAAAAGTCCATCACTCCTAAAATTCTCTGGGTGCCCTTCCCCAACCCCATCCCCTTCCCTCCTCCCTCAGAAATAACTGCTATTTTGTCTTTTGGGTTTATCATTTCCTAGCCCTTTTTGTCTTGTTTTGTTTTGTTTTTTTACAGTTTTACCATATTTGTTTATCTAAGCAATGCAGGTATTGTTTAGTTTGGGACATTTGTGAACCTTACACTTATGGACTCCAATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTT
TATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGGGGCTCTCACAGCCTTGGAAATCTCTTCACCCGCATCTCACGGGGCTCAGAATGAAAGGACATGCCATAAACCACACCTGCTGCCAACTCTAGGCGAGGAGTGTGAGTGAGTCAGCTCAGTGAGCACTCATAGTGGAAAGAATGCCCAGCGTGGCCACACAACTCAGGCTGCAGTCGGAATATACCGGTCCCTTGTAAAACCTGACTTGCTCAAAGCTTGACTCACAATCCACAGATTCCCCATTTTTAAGACCTTGGAGGCATTCTCCAAGACTTGAAGCTGTATCTTCACATGAAACAGGGAGGTCTCAGGAATCAAAGACCAGGATTCCTGCTTTTCTAGGTATATCTTAATTTAAAAATCAAGAAAGTTGGGAAAGGAGAATGTCATTGCCACAATTTTCTGTATACTAAACACACTGGCTGCTAAGACTCTTATGCCCAAACTTTATAAAGTCAGTTCTAATTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAATGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGTCCGCCACCATACCCAGCTAATTTTTGTATTTTAGTAGAGACGGGGTTTCGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCAATCAATTTCTAAATAGAGATTTTCATATCAAGTTTGCTGAAAGCTGAATATACACACATCTTCTAAGCATTCAAGCAAGACTTTATTGCCAGATGGGATGCCAAGGATTTTTTTGGAGAAAAGTAAGCAAAAATAAACACAGTGTTAAGCAAACAGTAATCATTCCACCTTCTCTTGTAAAAATCCCAGTGGAAGTTTTTGTCCTGAGTCACCCCTGTACGTAGCCTCTCACCGATTCTGCTGCAGAACTTACCTCTAGGTCAATCTTGAGGCCTTGGTGATACACCTCGGTCTCAAAGGTGATCAGTTGCAGCTCCTCAGTCACAATCAGGGAAGCCTACAGTAACGAGAAGGACACTCTTAGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATTGCCTGAGCCCAGGAGTTCGAGACCAGTCTAAGCAGCACAGCAAAACTCCATCTCTGCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTATAGCCCCAGCTACTCGAGAGGCTGAGGTGGGAGGATGGCTTGAGCCTAGGAGATGGAGGCTGCAGCGAGCTATGATTGTGCCACTGCACTCTAGCTGGGGTGACAGAGTGAGACCCTGTCTTAAAAAAAAATTAAATTAAATAAAAAAAAAGGCTGAGCGTGATGGCTCACACCTACAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACATGGTCAGGAGTTCGAGACCAGCCTGGCCAATAATTTGGTGAAACCCCGTTTCTACTAAGAATACAAAAATTAGCTGGGTGTGGTAGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAATCAATCAGTCAATCAATAAAAAAGAGAAGGACACTTTTCCTCAGAGAGAATGGCATTCAGTACTAACAGCCACAGCCAAGGAAAGTGACATGCCAAGCCTCACCACACCAAGAAGGGTAAGCCACCAGGTGGTCACAAACAAACTGCCAGGGACACAACTTGCTCGGCACTTACTCTCTTCAACACCAAGAACTTCCAATGCTGTGATCCTCAACCTAATCCTTTACTCAGTTTGTATTATAATATTACATAGATCCAATTGGTTATTTGTAAAATACGTAAGGCACAAAGAATAACAAAACAATATGAACCCACCATTCAATTTAAGGAAAAGTCCATCACTCCTAAAATTCTCTGGGTGCCCTTCCCCAACCCCATCCCCTTCCCTCCTCCCTCAGAAATAACTGCTATTTTGTCTTTTGGGTTTATCATTTCCTAGCCCTTTTTGTCTTGTTTTGTTTTGTTTTTTTACAGTTTTACCATATTTGTTTATCTAAGCAATGCAGGTATTGTTTAGTTTGGGACATTTGTGAACCTTACACTTATGGACTCCAATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTT
Task1_train_24390
Consider this mutation in STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Is this a benign change or a disease-causing variant?
Pathogenic; STAT3 gain of function
TATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGGGGCTCTCACAGCCTTGGAAATCTCTTCACCCGCATCTCACGGGGCTCAGAATGAAAGGACATGCCATAAACCACACCTGCTGCCAACTCTAGGCGAGGAGTGTGAGTGAGTCAGCTCAGTGAGCACTCATAGTGGAAAGAATGCCCAGCGTGGCCACACAACTCAGGCTGCAGTCGGAATATACCGGTCCCTTGTAAAACCTGACTTGCTCAAAGCTTGACTCACAATCCACAGATTCCCCATTTTTAAGACCTTGGAGGCATTCTCCAAGACTTGAAGCTGTATCTTCACATGAAACAGGGAGGTCTCAGGAATCAAAGACCAGGATTCCTGCTTTTCTAGGTATATCTTAATTTAAAAATCAAGAAAGTTGGGAAAGGAGAATGTCATTGCCACAATTTTCTGTATACTAAACACACTGGCTGCTAAGACTCTTATGCCCAAACTTTATAAAGTCAGTTCTAATTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAATGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGTCCGCCACCATACCCAGCTAATTTTTGTATTTTAGTAGAGACGGGGTTTCGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCAATCAATTTCTAAATAGAGATTTTCATATCAAGTTTGCTGAAAGCTGAATATACACACATCTTCTAAGCATTCAAGCAAGACTTTATTGCCAGATGGGATGCCAAGGATTTTTTTGGAGAAAAGTAAGCAAAAATAAACACAGTGTTAAGCAAACAGTAATCATTCCACCTTCTCTTGTAAAAATCCCAGTGGAAGTTTTTGTCCTGAGTCACCCCTGTACGTAGCCTCTCACCGATTCTGCTGCAGAACTTACCTCTAGGTCAATCTTGAGGCCTTGGTGATACACCTCGGTCTCAAAGGTGATCAGGTGCAGCTCCTCAGTCACAATCAGGGAAGCCTACAGTAACGAGAAGGACACTCTTAGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATTGCCTGAGCCCAGGAGTTCGAGACCAGTCTAAGCAGCACAGCAAAACTCCATCTCTGCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTATAGCCCCAGCTACTCGAGAGGCTGAGGTGGGAGGATGGCTTGAGCCTAGGAGATGGAGGCTGCAGCGAGCTATGATTGTGCCACTGCACTCTAGCTGGGGTGACAGAGTGAGACCCTGTCTTAAAAAAAAATTAAATTAAATAAAAAAAAAGGCTGAGCGTGATGGCTCACACCTACAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACATGGTCAGGAGTTCGAGACCAGCCTGGCCAATAATTTGGTGAAACCCCGTTTCTACTAAGAATACAAAAATTAGCTGGGTGTGGTAGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAATCAATCAGTCAATCAATAAAAAAGAGAAGGACACTTTTCCTCAGAGAGAATGGCATTCAGTACTAACAGCCACAGCCAAGGAAAGTGACATGCCAAGCCTCACCACACCAAGAAGGGTAAGCCACCAGGTGGTCACAAACAAACTGCCAGGGACACAACTTGCTCGGCACTTACTCTCTTCAACACCAAGAACTTCCAATGCTGTGATCCTCAACCTAATCCTTTACTCAGTTTGTATTATAATATTACATAGATCCAATTGGTTATTTGTAAAATACGTAAGGCACAAAGAATAACAAAACAATATGAACCCACCATTCAATTTAAGGAAAAGTCCATCACTCCTAAAATTCTCTGGGTGCCCTTCCCCAACCCCATCCCCTTCCCTCCTCCCTCAGAAATAACTGCTATTTTGTCTTTTGGGTTTATCATTTCCTAGCCCTTTTTGTCTTGTTTTGTTTTGTTTTTTTACAGTTTTACCATATTTGTTTATCTAAGCAATGCAGGTATTGTTTAGTTTGGGACATTTGTGAACCTTACACTTATGGACTCCAATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTT
TATCCTGGCCAACATGGTAAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGTGGTGAGCACCTGTAGTCTCAGCTACTCGGGAGGCCGAGGCAGAAGAATCGCTTGAACCCAGAAGGCGGAGGTTGCAGTGAGCCGAGATCACACTACTGCACTCCAGCCTGGGCAACAGAGCAAGACTCGTCTCAAAAAAATAAATAAATAAATAAAATAAGACAAAAAAAACCAACTAGCCTATAGTTTATTAAAAAAATGGACAGGGAATGTCAAGCCTTTAGTGCCACCTTCCAACACACACTTAAAAGATCTTCTAAAGTTAGATAGAGTGGGTGAATGAGACAGCAACCAGGAGAAAAGAAATCTACCTCCCACCTCAAAAATGATCACCTCGACTGAAAACTGCAAACTGTCTCTGCACCCCAACTCCCCAACTCCCCTGTTTCCTGGCACCAGCACAGCGCCTTGCTCAGGAAAGAAACATGGCCTAATGCTCAGTAGACATGGCCCAAATGAACAGCCCTATGGGCCGGATCCCTTTTCTGGGCGGGTGGGCGGGAGGGAGAAGGGGTGAAATGCGGACCCAAGAGTTTCTCTGCCAGTGTAGTCAGCTGCTCGATGCTCAGTCCTCGCTTGGTGGTGGAGGAGAACTGCCAGCTCAGGACCTCGGCCACTTGATCCCAGGTTCCAATTGGGGGCTTGGTAAAAAAGTTTACATTCTATTGGAAAGAACACATTTGCTTGTTTAGATGAGGGATGGTGCTCATTGTCTATACTAGGTACCCCTAAGTCGCAAGAGATCCCGGGGCACCAACTAAAAGGAGGGGGCACTAACCTTGGGATTGTTGGTCAGCATGTTGTACCACAGGATGGACGCCCAGGCATTTGGCATCTGACAGATGTTGGAGATCACCACAACTGGCAAGGAGTGGGTCTGCGGAGGGAGTGGGGACTGAGCTGGGGAGGCAGAGGGGCTCTCACAGCCTTGGAAATCTCTTCACCCGCATCTCACGGGGCTCAGAATGAAAGGACATGCCATAAACCACACCTGCTGCCAACTCTAGGCGAGGAGTGTGAGTGAGTCAGCTCAGTGAGCACTCATAGTGGAAAGAATGCCCAGCGTGGCCACACAACTCAGGCTGCAGTCGGAATATACCGGTCCCTTGTAAAACCTGACTTGCTCAAAGCTTGACTCACAATCCACAGATTCCCCATTTTTAAGACCTTGGAGGCATTCTCCAAGACTTGAAGCTGTATCTTCACATGAAACAGGGAGGTCTCAGGAATCAAAGACCAGGATTCCTGCTTTTCTAGGTATATCTTAATTTAAAAATCAAGAAAGTTGGGAAAGGAGAATGTCATTGCCACAATTTTCTGTATACTAAACACACTGGCTGCTAAGACTCTTATGCCCAAACTTTATAAAGTCAGTTCTAATTTCTTTTTTTTTTTTTTGAGACGGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAATGGCACAATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTATAGGCGTCCGCCACCATACCCAGCTAATTTTTGTATTTTAGTAGAGACGGGGTTTCGTCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCAATCAATTTCTAAATAGAGATTTTCATATCAAGTTTGCTGAAAGCTGAATATACACACATCTTCTAAGCATTCAAGCAAGACTTTATTGCCAGATGGGATGCCAAGGATTTTTTTGGAGAAAAGTAAGCAAAAATAAACACAGTGTTAAGCAAACAGTAATCATTCCACCTTCTCTTGTAAAAATCCCAGTGGAAGTTTTTGTCCTGAGTCACCCCTGTACGTAGCCTCTCACCGATTCTGCTGCAGAACTTACCTCTAGGTCAATCTTGAGGCCTTGGTGATACACCTCGGTCTCAAAGGTGATCAGTTGCAGCTCCTCAGTCACAATCAGGGAAGCCTACAGTAACGAGAAGGACACTCTTAGGCCAGGTGTGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGAGGATTGCCTGAGCCCAGGAGTTCGAGACCAGTCTAAGCAGCACAGCAAAACTCCATCTCTGCAAAAAATACAAAAATTAGCTGGGTGTGGTGGTGCACACCTATAGCCCCAGCTACTCGAGAGGCTGAGGTGGGAGGATGGCTTGAGCCTAGGAGATGGAGGCTGCAGCGAGCTATGATTGTGCCACTGCACTCTAGCTGGGGTGACAGAGTGAGACCCTGTCTTAAAAAAAAATTAAATTAAATAAAAAAAAAGGCTGAGCGTGATGGCTCACACCTACAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACATGGTCAGGAGTTCGAGACCAGCCTGGCCAATAATTTGGTGAAACCCCGTTTCTACTAAGAATACAAAAATTAGCTGGGTGTGGTAGTGGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGATGCAGTGAGCCGAGATCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAATCAATCAGTCAATCAATAAAAAAGAGAAGGACACTTTTCCTCAGAGAGAATGGCATTCAGTACTAACAGCCACAGCCAAGGAAAGTGACATGCCAAGCCTCACCACACCAAGAAGGGTAAGCCACCAGGTGGTCACAAACAAACTGCCAGGGACACAACTTGCTCGGCACTTACTCTCTTCAACACCAAGAACTTCCAATGCTGTGATCCTCAACCTAATCCTTTACTCAGTTTGTATTATAATATTACATAGATCCAATTGGTTATTTGTAAAATACGTAAGGCACAAAGAATAACAAAACAATATGAACCCACCATTCAATTTAAGGAAAAGTCCATCACTCCTAAAATTCTCTGGGTGCCCTTCCCCAACCCCATCCCCTTCCCTCCTCCCTCAGAAATAACTGCTATTTTGTCTTTTGGGTTTATCATTTCCTAGCCCTTTTTGTCTTGTTTTGTTTTGTTTTTTTACAGTTTTACCATATTTGTTTATCTAAGCAATGCAGGTATTGTTTAGTTTGGGACATTTGTGAACCTTACACTTATGGACTCCAATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTT
Task1_train_24391
This variant lies on Chromosome 17 and affects the gene STAT3 (signal transducer and activator of transcription 3). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; STAT3 gain of function
AATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTA
AATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTTGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTA
Task1_train_24392
This sequence variant lies in STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Is it clinically significant, and what condition might it cause if any?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
AATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTA
AATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTTGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTA
Task1_train_24393
The gene STAT3 (signal transducer and activator of transcription 3), on Chromosome 17, contains a mutation. Does this mutation cause a disorder, or is it a benign change?
Pathogenic; STAT3-related early-onset multisystem autoimmune disease
AATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTA
AATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTTGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTA
Task1_train_24394
A variant was discovered in gene STAT3 (signal transducer and activator of transcription 3), Chromosome 17. Please indicate if this mutation results in a known disease or if it's non-harmful.
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
AATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTA
AATGAATTCTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTTGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTA
Task1_train_24395
Given a variant located on Chromosome 17 and affecting STAT3 (signal transducer and activator of transcription 3), assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.
Pathogenic; STAT3-related early-onset multisystem autoimmune disease
CTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAA
CTTTTGGGATTCACTTTTCACTTGATGTGAAATGAATCCACATGGTTATGTGTATCTGCAGTGTATTCCTTTTCACAGCTGCGGAGTATTCCATTGTGTCTATACCACAAATAATGTATTCATTCTAATGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCCTTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAA
Task1_train_24396
The gene STAT3 (signal transducer and activator of transcription 3) on Chromosome 17 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
TGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGACCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGAAGAAATGTAAAAT
TGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTATTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGACCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGAAGAAATGTAAAAT
Task1_train_24397
A variant found in Chromosome 17 affects STAT3 (signal transducer and activator of transcription 3). Please analyze its biological impact: is it benign or pathogenic, and what condition might it cause?
Pathogenic; STAT3 gain of function
TGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGACCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGAAGAAATGTAAAAT
TGTTGATGGGTATTTATTTGGGTTGCATTTAGAGCTTATAATCAGGCTGATGTCCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTATTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGACCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGAAGAAATGTAAAAT
Task1_train_24398
This variant lies on Chromosome 17 and affects the gene STAT3 (signal transducer and activator of transcription 3). Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?
Pathogenic; STAT3-related early-onset multisystem autoimmune disease
CCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGACCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGAAGAAATGTAAAATTCATAATTCTTCATTTCCAACAGGTAAATAGGCCAAGCTGTCTATAATTACAG
CCACTTTATATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTCTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGACCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGAAGAAATGTAAAATTCATAATTCTTCATTTCCAACAGGTAAATAGGCCAAGCTGTCTATAATTACAG
Task1_train_24399
An alteration has been detected in STAT3 (signal transducer and activator of transcription 3) on Chromosome 17. Is it pathogenic, and if so, what disease is involved?
Pathogenic; Hyper-IgE recurrent infection syndrome 1, autosomal dominant
ATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTGTGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGACCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGAAGAAATGTAAAATTCATAATTCTTCATTTCCAACAGGTAAATAGGCCAAGCTGTCTATAATTACAGGCTCACATC
ATATGTCTCCTGGGACATATATGCAAAGATTTCTCTGCTATTAAATCCTGGGAATGGCACCGTTGGTTTACAGGTATGTTCATTTTTATACTGCCAAATTGTTTTCCAAACTGACTACAACAATGTCTCACATCAGTACAGCAACCTTATTTTAAGTAAGAGTTGTCAATGAATTCTCAAAAATTGAATTCTAGTCTGGGCACAGCGGCTCATGCCTGTAATCCCAGCACTTTCGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCTGTCTCTACTAAAAATGCAAAAATTAGCCAGGCGTGGTGGCATGCACCTATCGTCCCAGCTACTTGGGAGGCTGAGACAGGAGAATCGCTTGAACCTAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGCACCACTGCAATCCGATAGAACGAGACTCCGACTCAAAAAAAAAAAAGAAAAAAGAAATTAAATTATAATTCATTTTTAATACTATTTTTCTGATTATAAAAGTAATATATTCAGTTTAAAATGCAAATATCACAGAGACAGTCTAGAATAGCCATGGATACCAACAGCAGCACTAATACACATAGCACTGCTGGTATATTCCTCCAGAATTTCTTAATATACATATGAATACACATAAGAGTATAGTGTATTTTTAAAACACATATACTAATAATACTATTCAAATTATTTTACATTTTGCTTTTTCTTAATATGTCATGTACATTTTCCCATATCATTGCATACAGGCTACTTCACTCTACTGTCAAGTAAAATTCCACATTTTTAAAAAGGACTGCTACATTTTATTTTATTTATTTTTTTGAGACAGAGTTTCACTCTGTTGCCCAGGCTAGAGTGCAGTGGCAAAATCTTGGCTCACTGCAAGCTCCACCTCTCAGGTTCAAGCGATTCTCATGCCTCAGCCTCCCCAGTAACTGGGACTACAGGCGTGCACCACCACACCCAGCTAATTTTTGTATCTTTAGTAGAGACGGGCTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAAGTGACCAGCCTGCCTTGGCATCCCAAAGTACGGGGTGTGAGCCAGCACGCCCAGCTAGGACTGCTACATTTTAAAGAGGAAGAATTGTTCAGGGGACAAATGTAAGAAAAAGAACGGGGCATCACAATTTTTAAAAATGACTGAAAACTAGCCTTCCGTCACATTTACCTTTTTTTGTTTGTTTGTTTAAAGTTTATTCTTGACAATAAGAATCCAATAATCTGAATCAATGAAAAGCAGAAAATAAGGGGGATAAAGAACAAGATGGGTTTTTGTTTGTTCATTTTATTTTATGTACTCTTTTCCTAAGCAAGCTAATGCAAGGTGGTCATTTATTTTAAAGTTTAACTCAAATCTGTTGCTTTTACACCCTCTATCCCACCTCAGTGGGAGAGAAAAACAGGGCACTAAAAATGGAGCCAAGCAGGGTCAGCCGCAGGAGCTGGATGGGGAATTTGGAAAGCCCCAGGCAAGGTGGAAAGCTGCTTTATACCACATGGGTGTGGAGAACAACTCAGCAAGGGACTTTCCACTTCTCCTTAAGGAGGAGCCAACTCCCAGATATTCACGGAAATGTTCCAAGCCAGAGAGCTCCATGGCACATGGAACTTCTGTTCATGTCACTTTGGCCTGAAGTGACTTTTTGGAATAACTACAGCTGAAAGAACAGGTTGATGTTTCTAATTCTGGGGATTAAGAAGGATCTTTACCCCTCTCTCCCTCAAGGAAAACACCCCAGTTGTCTTTCATCCCCAACAAAACTTACATCACAATTGGCTCGGCCCCCATTCCCACATCTCTGCTCCCTCAGGGTCTGTAAGAAAAGAAAAAGGCAGGTGTCCTGTGAGGCTCTCCCTAGCCCTCTCCGGCAGCCAGAGGCCCTTTGTGAAGGGGAGCTCCTCCCACATACCAAGTGTTTGAATTCTGCAGAGAGGCTGCCGTTGTTGGATTCTTCCATGTTCATCACTTTTGTGTTTATGCCCAGAATGTTAAATTTCCGGGATCTGAATCACAGGGGAACAATCAACTATGTAGGTGACCAAGTAGCCGGAGGATGAAGTTAGGTTAAACGGAACAAAAGGAAGCCTCTAGGCTGAACTTACCCTCTGAGAGCTGCAACGTCCCCAGAGTCTCTGTAAGAACACAGACTGTTGTTAATAAAATAGGCTCTGTGTTTCTTCAAAAAGCCTACTTTGACCACCTGTTATTTACTGTCATGAAAAAACCTCTGTGCTCCTGGGCATTTCTTTAAACTATTCAGTTACAGTTGATCAGCGCAACATAACACCTCTGCGTAGCAGGCACAGTTGGTTGCCTCCCCATAGGAAGGGGAACCTATGTTTCATATTGCATATGTACTTATTAAACCTACCACCTTCGTCAACTCCCTTATTTCATTATTTTCCAGTGCATCCTCATGAAATTTCCACATAATTACATCAACTAAAAATAAGAATGCATTTTATCTTTTCTTTTTTCTTTTTTTTTTTTTGAGATAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGTGATCTCGGCTCACCACAACCTCCACCTCCTGAGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGTGTAGCTGGGATTACGGGCATGCGCCAACACACCTGGCTAATTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCGGGCTGGTTTCGAACTCTCGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGAGATTACAGGCGTGAGCCACCGCGCCCAGCCACATTTTCTCTTTTCTTTTCTTTTTTTTTTTTTTTGAGATGGAGTCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCACCTCCCAGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCCGCCACCACGCCCAGCTAGTTTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTACCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCCGGCCCACATTTTCTCTTTTCTAATGTCGTCAAAGGGTATATGTATTTTACATCCTGAAAGGTATTGTGAAATTTTGCGTATTCCATTATATGGTAAAGTGTGGAACAATTAAAAAAAAGAGATCTATTCTTTCCACATGCTATGTATGGAAAGAATATATAACGACGTTTCGGTCAACAACAAAATGCATATATGATGGTGGTCCCATAAGATTATCATGGAGCTGAAAAATTCCTACTTCATTGAGATGTGTTACAATTGCCTACGGTATTCAGCACAGTAACATACTGTACAGGTTTACAGCCTACGACCAGTAGGCTCTGCCACATAGCGTAGGTGTGCAGTAGGTTCTGCCACCCAGGTTTGTGTAAGGACTATATACTCTACAACATTTGCACAACAAAATTGCCTAATGATACATTTTGCAGAACGTATCCCAGTCGTTAATTAACACATGATCTCAGTCTTATATATAATATGCATGAATGACATGTACAAGTAAAAAACTAAACAAGGAAAAGAGGGACTGGTTGTCACAATAGCAACCACAAATCAAATCTGTACCCCCAGCTTTGTGGCTTTGTTCAGACACGTAAATGACAATGCACCCCAAGGCTTTTGAAAACTTTTGTCCACAAAATGAAGATCTCTGAATAAAGACAGAGTCTCTAGTTCAAATGATGTCTGTCAAAGTTCTCATTTTTCTATTCCTCATTTGAAAAACAGAGCTAAGATAGGAGTACTTACTTGTCAATGCACACTTTAATTTTAAGCTGATAATTCAACTCAGGGAATTTGACCAGCAACCTATTTAAAAAGAAAAAATCCAAGGAAAAAAAGTCAGTAACTCTCCCATAACCTTTTCTTGAAGAAATGTAAAATTCATAATTCTTCATTTCCAACAGGTAAATAGGCCAAGCTGTCTATAATTACAGGCTCACATC