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train · 48.9k rows

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ID stringlengths 13 17	question stringlengths 88 1.13k	answer stringlengths 6 156	reference_sequence stringlengths 4.1k 4.1k	variant_sequence stringlengths 4.1k 4.1k
Task1_train_46000	Consider this mutation on Chromosome 18. Is this a benign change or a disease-causing variant?	Benign	ACTGAATTAGTTTCTGGAGGATCTGATAATCAAGTGATTCACTGGGAAATAGAGGATAATCAGGTGAGTGGACATGTTTATAATCAAGAAATGACTTTTTTTGTTCATTTGTTTTTTAAGAGGTAGAGTTTCACTCTGTCACCCAGGCTGACGTGCAGTGGTGCGATCGTGGCTCACCTCAGCCTCCTAAGTAGCTGGGACTACAGGTGCCTGACACCATGCCTGGCTGATTTCTGTTTGTTTGTTTGTTTGTTTTTGTAGAGATGGGGTCTTACTTTGTTGCCCAGGCTGGTCTCAGAAATGACTTTTATATATACTTT...	ACTGAATTAGTTTCTGGAGGATCTGATAATCAAGTGATTCACTGGGAAATAGAGGATAATCAGGTGAGTGGACATGTTTATAATCAAGAAATGACTTTTTTTGTTCATTTGTTTTTTAAGAGGTAGAGTTTCACTCTGTCACCCAGGCTGACGTGCAGTGGTGCGATCGTGGCTCACCTCAGCCTCCTAAGTAGCTGGGACTACAGGTGCCTGACACCATGCCTGGCTGATTTCTGTTTGTTTGTTTGTTTGTTTTTGTAGAGATGGGGTCTTACTTTGTTGCCCAGGCTGGTCTCAGAAATGACTTTTATATATACTTT...
Task1_train_46001	Located on Chromosome 18, this mutation has been observed. What is its biological consequence — is it benign or pathogenic, and which disease is associated if any?	Benign	AAAGACAAGCTAAATCTCACCATTTGAGTAGTATATTTAATTCTGATTTTCCTATTGTCTAGCCTTAGAACAGTATCCCTGGATGGTAGATCCTGTTGGGATGTTGTATTTGAAAGAGATATTTTTGGATGTGACAGTTATAAAGGTAGTTCAGTGAACATTGTTCACCTAGGTGTATTCTGTTTTTTGTTACTATTCTTGGTGGTAAAGTCCATCAGAGTTGAGATTTTGGTAACAGTTTTATGGGGAGAACGAAAAAATGATATAACCAGCATATTAGGAGTAGCTATACCCAAATATGAATTTTTTTCTATTTTCAT...	AAAGACAAGCTAAATCTCACCATTTGAGTAGTATATTTAATTCTGATTTTCCTATTGTCTAGCCTTAGAACAGTATCCCTGGATGGTAGATCCTGTTGGGATGTTGTATTTGAAAGAGATATTTTTGGATGTGACAGTTATAAAGGTAGTTCAGTGAACATTGTTCACCTAGGTGTATTCTGTTTTTTGTTACTATTCTTGGTGGTAAAGTCCATCAGAGTTGAGATTTTGGTAACAGTTTTATGGGGAGAACGAAAAAATGATATAACCAGCATATTAGGAGTAGCTATACCCAAATATGAATTTTTTTCTATTTTCAT...
Task1_train_46002	Consider a variant on Chromosome 18. Determine its clinical classification and disease relevance.	Benign	CCTCTGGTCTTTCCTTTGTTTTCATACTCTTTAAAATATCCTTTTGTTCCTACAGACTAGAGGTGGTGAAGCAGTTTAGTGTTGGCCATTCCTCTCCCTGCCTTCTTTAGTCACAGACAAGGTACAGATCACTGAAGTGGAGTGCTAGCACAGACAGGGTGTCACTCAGGCTAAACACTTACATGTCAACCTCTATGGCAGACTTTACATCTCAGACCCTCCCTTCTGTTCATTTGCCTGTTCTTTCTTTCTTGGCATTGGTGTGCCTGTGCTGTGCTTGATGCTGAGGAAGAAGGACTGCTTTTGTCCCCCACAGTCAT...	CCTCTGGTCTTTCCTTTGTTTTCATACTCTTTAAAATATCCTTTTGTTCCTACAGACTAGAGGTGGTGAAGCAGTTTAGTGTTGGCCATTCCTCTCCCTGCCTTCTTTAGTCACAGACAAGGTACAGATCACTGAAGTGGAGTGCTAGCACAGACAGGGTGTCACTCAGGCTAAACACTTACATGTCAACCTCTATGGCAGACTTTACATCTCAGACCCTCCCTTCTGTTCATTTGCCTGTTCTTTCTTTCTTGGCATTGGTGTGCCTGTGCTGTGCTTGATGCTGAGGAAGAAGGACTGCTTTTGTCCCCCACAGTCAT...
Task1_train_46003	A variant affecting Chromosome 18 has been observed. Determine if it's benign or associated with disease.	Benign	CAAAACACACTTCCCTGCCTGGGCTCTGGAGACTGACTTCCCAGGTGCTAGCTTGTCTTCTAGCTGTGTGCCCGTGTGCAAGTTATTCTGCCTCTCTCTGCCTCAGCTTCCCCATCTGTAAGAGCCACCTCCTAGATCTGCATATTTAATCATTGAACGACCAGGACAGGTAAGAGTGTACACAGTGCAGTGCCTGGCACACAGTGAGGCCCTGTAACTAGCTCTTGTTATTAGTGCTGCCCAAAGCCACATTCACAGAAGACAGTCCAGTATCCAAAGTGCCTGCTTGAAGCATGGCCAGAAGGCAAGCAGATGGTGGG...	CAAAACACACTTCCCTGCCTGGGCTCTGGAGACTGACTTCCCAGGTGCTAGCTTGTCTTCTAGCTGTGTGCCCGTGTGCAAGTTATTCTGCCTCTCTCTGCCTCAGCTTCCCCATCTGTAAGAGCCACCTCCTAGATCTGCATATTTAATCATTGAACGACCAGGACAGGTAAGAGTGTACACAGTGCAGTGCCTGGCACACAGTGAGGCCCTGTAACTAGCTCTTGTTATTAGTGCTGCCCAAAGCCACATTCACAGAAGACAGTCCAGTATCCAAAGTGCCTGCTTGAAGCATGGCCAGAAGGCAAGCAGATGGTGGG...
Task1_train_46004	A variant has been detected on Chromosome 18. What is its effect — pathogenic or benign? If pathogenic, name the disease.	Benign	ATAAATCAGTTAGATGTTTTCATTCCCCTGAAAAGATCCTTCATGCCCATTACAGCTAATCCTTGTTGCTGACCTTACCCCCAGGCAATTGCTAATCTACTACTTTCTGTATCTCTACAATTCTTTTGCTGGACATTTAATGTAAATTGATTCATGCATTATGTATATTCTTGTGTCTGGAGTATTTCATTTATCATGCTTTTGAAGTTCTTTCATGGCATAGCCAGTAGTTTGTTCCTTTTTATTGGCAAATAACTTCCCTGGCTGGGCACAGTGGCTCATGCCTGCAATCCTAGCACTTGGGGAGGCTGAGGCAGGAA...	ATAAATCAGTTAGATGTTTTCATTCCCCTGAAAAGATCCTTCATGCCCATTACAGCTAATCCTTGTTGCTGACCTTACCCCCAGGCAATTGCTAATCTACTACTTTCTGTATCTCTACAATTCTTTTGCTGGACATTTAATGTAAATTGATTCATGCATTATGTATATTCTTGTGTCTGGAGTATTTCATTTATCATGCTTTTGAAGTTCTTTCATGGCATAGCCAGTAGTTTGTTCCTTTTTATTGGCAAATAACTTCCCTGGCTGGGCACAGTGGCTCATGCCTGCAATCCTAGCACTTGGGGAGGCTGAGGCAGGAA...
Task1_train_46005	A mutation located on Chromosome 18 is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.	Benign	AAGCATGCTCCCTTCTCAGGTCTTTGCACTTGCTGTTCCCTCTGCCTGGTGCTCTTCCCCTAGTTATACCTCCACAGGGCTGTTCTCTCACCTCTGTCAGTTTCATCTCCAACAGGTCTCTGTTCAAAAGCCCCCTTCTCAGAGGGCCACATGACTACCCACAGAAAACAACCTCTCCCTCTTCATTTCCCCTTTTGTATTCATCTCCTTTGCCTTTGTTGTTTCCAAGTTAATATATATCTGTTTATTGATCTTTAGTCCCTCCCACTAGAATGCCCATGTTGTTCCCTTCAGAGCCTGGGACAGTGTCAAGAGGACAG...	AAGCATGCTCCCTTCTCAGGTCTTTGCACTTGCTGTTCCCTCTGCCTGGTGCTCTTCCCCTAGTTATACCTCCACAGGGCTGTTCTCTCACCTCTGTCAGTTTCATCTCCAACAGGTCTCTGTTCAAAAGCCCCCTTCTCAGAGGGCCACATGACTACCCACAGAAAACAACCTCTCCCTCTTCATTTCCCCTTTTGTATTCATCTCCTTTGCCTTTGTTGTTTCCAAGTTAATATATATCTGTTTATTGATCTTTAGTCCCTCCCACTAGAATGCCCATGTTGTTCCCTTCAGAGCCTGGGACAGTGTCAAGAGGACAG...
Task1_train_46006	With a mutation on Chromosome 18, classify this variant as benign or pathogenic. Include the disease if it's pathogenic.	Benign	AATTTCTTTTTAGTTCTTGCAGTTACAATGCAGAAGGATACTCCTAGGAAATAGAATTCCCAATGAGATTTTGTAAAGATAGAGCTTTTATCAATTCTTGCCTCAAACCTCCCAAAATTATGTTTGGTGAATTCTAGGGGAGTAAAACAGTCAAAAGTCTGTTAAATTATCGTCACCTATGGGAGTTTGTTATAAGATGTATCTGGCATGTAGATGGAAGAGATTTTGTGAAAGCTTGAGCTGGTGGAAACAGGGTAGGGCAGATAAGGGTGGATACACTCCTGGTAAACGGTTTGTGTATCTCAGGTGCTGATATGTCC...	AATTTCTTTTTAGTTCTTGCAGTTACAATGCAGAAGGATACTCCTAGGAAATAGAATTCCCAATGAGATTTTGTAAAGATAGAGCTTTTATCAATTCTTGCCTCAAACCTCCCAAAATTATGTTTGGTGAATTCTAGGGGAGTAAAACAGTCAAAAGTCTGTTAAATTATCGTCACCTATGGGAGTTTGTTATAAGATGTATCTGGCATGTAGATGGAAGAGATTTTGTGAAAGCTTGAGCTGGTGGAAACAGGGTAGGGCAGATAAGGGTGGATACACTCCTGGTAAACGGTTTGTGTATCTCAGGTGCTGATATGTCC...
Task1_train_46007	A variant on Chromosome 18 is under investigation. Evaluate whether it is clinically benign or pathogenic and name the disorder if relevant.	Benign	GATGTTTGGTCGCCATCCCACCTTCAGTTGAAAATGAGCTGTAGGAAATTCTGTAGGCTATCACTGAAACAGGGATATGCCTCCCTATCTGCTGAAAGGTGCATGTTCTGCCCACCTGCACAAACCCTTAAACCCTCAGGTATGCACATGCTTCTGCACCTTCAGACCAGATGGAAGAATCTGGCTGGAAAAGGCGGCCTTCAAAGGCATCCCTGTTAATGGTGTGCTGTCTCTACCTAGGATTTTTATTATACAGGTAGATGATTGTTTATCTTATGCCTGGAAGAGTCTCTGACTCCACAAAGTGATGCCAGAGGGCA...	GATGTTTGGTCGCCATCCCACCTTCAGTTGAAAATGAGCTGTAGGAAATTCTGTAGGCTATCACTGAAACAGGGATATGCCTCCCTATCTGCTGAAAGGTGCATGTTCTGCCCACCTGCACAAACCCTTAAACCCTCAGGTATGCACATGCTTCTGCACCTTCAGACCAGATGGAAGAATCTGGCTGGAAAAGGCGGCCTTCAAAGGCATCCCTGTTAATGGTGTGCTGTCTCTACCTAGGATTTTTATTATACAGGTAGATGATTGTTTATCTTATGCCTGGAAGAGTCTCTGACTCCACAAAGTGATGCCAGAGGGCA...
Task1_train_46008	A variant was discovered on Chromosome 18. Please indicate if this mutation results in a known disease or if it's non-harmful.	Benign	ATTCTGTAGGCTATCACTGAAACAGGGATATGCCTCCCTATCTGCTGAAAGGTGCATGTTCTGCCCACCTGCACAAACCCTTAAACCCTCAGGTATGCACATGCTTCTGCACCTTCAGACCAGATGGAAGAATCTGGCTGGAAAAGGCGGCCTTCAAAGGCATCCCTGTTAATGGTGTGCTGTCTCTACCTAGGATTTTTATTATACAGGTAGATGATTGTTTATCTTATGCCTGGAAGAGTCTCTGACTCCACAAAGTGATGCCAGAGGGCATCCTTTACCAGAGACCATTAGGCTTTTCAGTTTTAGGAAATAAACAT...	ATTCTGTAGGCTATCACTGAAACAGGGATATGCCTCCCTATCTGCTGAAAGGTGCATGTTCTGCCCACCTGCACAAACCCTTAAACCCTCAGGTATGCACATGCTTCTGCACCTTCAGACCAGATGGAAGAATCTGGCTGGAAAAGGCGGCCTTCAAAGGCATCCCTGTTAATGGTGTGCTGTCTCTACCTAGGATTTTTATTATACAGGTAGATGATTGTTTATCTTATGCCTGGAAGAGTCTCTGACTCCACAAAGTGATGCCAGAGGGCATCCTTTACCAGAGACCATTAGGCTTTTCAGTTTTAGGAAATAAACAT...
Task1_train_46009	This mutation is located on Chromosome 18. Is it associated with a disease or is it a benign polymorphism?	Benign	CCACCCACTCCAGACTCATTTGATTTCTTGCAGTGGGATTCTGACCTCCTGAATTCCTGGACCTGTCCAGATTCTCTTATTTGCACTCATTTCTTGCCTGCCCCTTTATCCTGTGGCAGCAGTGTGGGAATGCCTGTGCTCACAACTCCTGGACTTAGGGCATTTCTGGCCTTGAACTTGCCACCATCCCATTTAACACATACCTGCTGGAGGCCCTGCCTCTTACCCTTAAAATTGTTTTCTTTCAAGGTTCTTGTTACTTCCACAGCCAAGTGGCTTTTTCTTGCTGGCCCGAATTAAGGCCACAAACACATTCCTTT...	CCACCCACTCCAGACTCATTTGATTTCTTGCAGTGGGATTCTGACCTCCTGAATTCCTGGACCTGTCCAGATTCTCTTATTTGCACTCATTTCTTGCCTGCCCCTTTATCCTGTGGCAGCAGTGTGGGAATGCCTGTGCTCACAACTCCTGGACTTAGGGCATTTCTGGCCTTGAACTTGCCACCATCCCATTTAACACATACCTGCTGGAGGCCCTGCCTCTTACCCTTAAAATTGTTTTCTTTCAAGGTTCTTGTTACTTCCACAGCCAAGTGGCTTTTTCTTGCTGGCCCGAATTAAGGCCACAAACACATTCCTTT...
Task1_train_46010	This mutation occurs on Chromosome 18. Does this change lead to a known medical condition, or is it benign?	Benign	GCTGGATTTCCTGGCTTTGGGATATAGGCTGGGGGAGAGCCTCAGTCAAGACAAAGGAGTGGGGGCCACAGAATAACAGCAGTGAGGGTGGGGGAGATGGAGGCCATGAGGCTACAGAGCAGGCTGGAGGTCTGAGGGAGGGTGATCATGAAAGCAGTGGGGTAGAGGGCAGTAGCCTTCTAGTGAGCAGCCCAGGCTGCCAGGTGGCTAGCCGTGGAGTGCCTTGAGGGGAGGAGGAGGCCTGGGGCAGTTCAGGGACATCGAGCGCACAACTTTCATTGCCAATCTGCCTGGAAGGACAAAAAGCAAAGAAGAAGACT...	GCTGGATTTCCTGGCTTTGGGATATAGGCTGGGGGAGAGCCTCAGTCAAGACAAAGGAGTGGGGGCCACAGAATAACAGCAGTGAGGGTGGGGGAGATGGAGGCCATGAGGCTACAGAGCAGGCTGGAGGTCTGAGGGAGGGTGATCATGAAAGCAGTGGGGTAGAGGGCAGTAGCCTTCTAGTGAGCAGCCCAGGCTGCCAGGTGGCTAGCCGTGGAGTGCCTTGAGGGGAGGAGGAGGCCTGGGGCAGTTCAGGGACATCGAGCGCACAACTTTCATTGCCAATCTGCCTGGAAGGACAAAAAGCAAAGAAGAAGACT...
Task1_train_46011	A genomic change on Chromosome 18 is noted. Classify this variant as benign or pathogenic, and name the disease if relevant.	Benign	TGGCGATTTACAGAGGTGATGATAGCACACTACAGCCTCAATCTCCTGGGATCCAGTGATCCTCTTGCCTCAGCCTCACAAGTAGCTAGGAATACAGGCTCATGCCACTGCTCCCGGCTTACTGTGTATTCTATTTTTTGCTGATGATCCTCTCTCTGACTGCTGAGTCCCCTGACAGAAGTCACTGTTTTTCCATTTAGGTTTAATGAGACTTAGGTATACTTGTTGTACTATCCTAAAATGCATGAATCTAGCAGGTGTCGGAAGGCCAAGTGGTTTTTATCCCCATTTGTATGTGGAACAATGTGATCCCATGAAGC...	TGGCGATTTACAGAGGTGATGATAGCACACTACAGCCTCAATCTCCTGGGATCCAGTGATCCTCTTGCCTCAGCCTCACAAGTAGCTAGGAATACAGGCTCATGCCACTGCTCCCGGCTTACTGTGTATTCTATTTTTTGCTGATGATCCTCTCTCTGACTGCTGAGTCCCCTGACAGAAGTCACTGTTTTTCCATTTAGGTTTAATGAGACTTAGGTATACTTGTTGTACTATCCTAAAATGCATGAATCTAGCAGGTGTCGGAAGGCCAAGTGGTTTTTATCCCCATTTGTATGTGGAACAATGTGATCCCATGAAGC...
Task1_train_46012	An alteration has been detected on Chromosome 18. Is it pathogenic, and if so, what disease is involved?	Benign	TACACATAATCTCACGCTTTTTATATATATATACTTTTAACTTTTATATATCTTTACTAAGCTTGTCATTTACCTGCCCCAAGGATTTTTTTTTTTTTTTTTTTTTTGGATACAGCATCTCACTCTGTCACCCAGGCTGAAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCTGTCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCTGCCACCACGCACAGCTAATTTTTGTATTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTTA...	TACACATAATCTCACGCTTTTTATATATATATACTTTTAACTTTTATATATCTTTACTAAGCTTGTCATTTACCTGCCCCAAGGATTTTTTTTTTTTTTTTTTTTTTGGATACAGCATCTCACTCTGTCACCCAGGCTGAAGTGCAGTGGTGTGATCTTGGCTCACTGCAACCTCTGTCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCTGCCACCACGCACAGCTAATTTTTGTATTTTTAGTAGAAATGGGATTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTTA...
Task1_train_46013	The following genetic variant occurs on Chromosome 18. Classify its clinical effect — pathogenic or benign — and list any associated condition.	Benign	CCACTGCTTGGATGGTTCCCTCTGTCACTCTCCTCTTACACTGTCCAGGTTTTAGCACTGAAAGTCATATGTGTGGGAAGCCTCTCAGTCCCAGGCCAACCAGAACAGTTGGTCGCCCCGTGTCTAACATACCTGTCTAACTGTCTCCAGGGCATGGCTCATCAGCGTGGCTGTGGCACCCTCTCCCTGCCTTCTCTTGTCTCCTTCACTGTCAAGTCTGGGAAAGGGCTCCTGGTGGGTGTCCGATGAGGCACAGCTGGGTGACAAAGATGGCTCCAGCTCTGGTTGGGGCGTGCACCTCATGGTGACACCTCCCTCTG...	CCACTGCTTGGATGGTTCCCTCTGTCACTCTCCTCTTACACTGTCCAGGTTTTAGCACTGAAAGTCATATGTGTGGGAAGCCTCTCAGTCCCAGGCCAACCAGAACAGTTGGTCGCCCCGTGTCTAACATACCTGTCTAACTGTCTCCAGGGCATGGCTCATCAGCGTGGCTGTGGCACCCTCTCCCTGCCTTCTCTTGTCTCCTTCACTGTCAAGTCTGGGAAAGGGCTCCTGGTGGGTGTCCGATGAGGCACAGCTGGGTGACAAAGATGGCTCCAGCTCTGGTTGGGGCGTGCACCTCATGGTGACACCTCCCTCTG...
Task1_train_46014	A mutation located on Chromosome 18 is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.	Benign	GGAAAAAAAGACAGTCCATTAAAGCGGTGGTGGAAAAGATCATGCCAGAGAAAGCCTTGGCTTCTGGAATCACCATGAGCAGTGAAGTAGTTAACAGGATACTTTCCAACTCTGAGGGGAATAAGAAGGATCCCCGTGTCCCTAAGTTGAGTAAAATGATAGAGAATGAGTCCCCCTCAGTTGGCCTTGAAACTGGTGGAAATGCTGAGAAAGTTATCCCAGGAGGTGTGTCTAAGCCGCGGAAGCCACCCATGGTCATGACACCTCCAACGTGCACAGATCACTCTCCATCCAGAAAGCTGCCAGAAATCCAGCATCCA...	GGAAAAAAAGACAGTCCATTAAAGCGGTGGTGGAAAAGATCATGCCAGAGAAAGCCTTGGCTTCTGGAATCACCATGAGCAGTGAAGTAGTTAACAGGATACTTTCCAACTCTGAGGGGAATAAGAAGGATCCCCGTGTCCCTAAGTTGAGTAAAATGATAGAGAATGAGTCCCCCTCAGTTGGCCTTGAAACTGGTGGAAATGCTGAGAAAGTTATCCCAGGAGGTGTGTCTAAGCCGCGGAAGCCACCCATGGTCATGACACCTCCAACGTGCACAGATCACTCTCCATCCAGAAAGCTGCCAGAAATCCAGCATCCA...
Task1_train_46015	A genetic alteration is present on Chromosome 18. Is this variant benign or disease-causing, and if the latter, which condition is involved?	Benign	CTGCACATTGGAATCACCTGCATCCCATCCCAGTGACTAGTTTAATTCATCTGCAGAGCAGCCTGGGTGGGCATCAGGAGCTTCTAAAGCTCTCCAGGAGATTCTAATTTGCCAGCAAATCAAAAACCACTGGTCTAGGAGGCTAGAGATGAACAGTTCCCATCTATGGCAATGGTGGGGAGGCCAAGGGCACAGGTAGAGACCCATGGTGGGGAAAGTGCTGCCAAAGGCCAGGAAGAGGGTATCCAAGGGCCGCTAAAGCTGAACAAGTGGAGGCCAGAAATTTGGACGTGGAAGCTGAGAACATGTGGCAGCAAACA...	CTGCACATTGGAATCACCTGCATCCCATCCCAGTGACTAGTTTAATTCATCTGCAGAGCAGCCTGGGTGGGCATCAGGAGCTTCTAAAGCTCTCCAGGAGATTCTAATTTGCCAGCAAATCAAAAACCACTGGTCTAGGAGGCTAGAGATGAACAGTTCCCATCTATGGCAATGGTGGGGAGGCCAAGGGCACAGGTAGAGACCCATGGTGGGGAAAGTGCTGCCAAAGGCCAGGAAGAGGGTATCCAAGGGCCGCTAAAGCTGAACAAGTGGAGGCCAGAAATTTGGACGTGGAAGCTGAGAACATGTGGCAGCAAACA...
Task1_train_46016	Chromosome 18 is altered by this variant. Does this mutation result in a disease or is it benign?	Benign	CCAGGCTGGTCTCAAACCTCTGGCCTCAAGCGATCATGCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGGACCATTACACCTGGCTGAGAACTATTTGTGTTAGTCGGATCCTTGATCATTTTGTGTGTGTGAGGACCTTCTTGGACCAGAAACAAGAAAAGGTGCTGTGCTGGCAGTTCAGCTTCTTAAGCTGCCCGTTCTTAGTCTACCCAATTAATATCTTTTGGAGACAAACTTGCTCTAAGTGGCATGCTATGGGGAAATGATGTCAGAAAATGCAGATTTTAGATATTGCATTCTATATGTCACAGT...	CCAGGCTGGTCTCAAACCTCTGGCCTCAAGCGATCATGCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGGACCATTACACCTGGCTGAGAACTATTTGTGTTAGTCGGATCCTTGATCATTTTGTGTGTGTGAGGACCTTCTTGGACCAGAAACAAGAAAAGGTGCTGTGCTGGCAGTTCAGCTTCTTAAGCTGCCCGTTCTTAGTCTACCCAATTAATATCTTTTGGAGACAAACTTGCTCTAAGTGGCATGCTATGGGGAAATGATGTCAGAAAATGCAGATTTTAGATATTGCATTCTATATGTCACAGT...
Task1_train_46017	This mutation on Chromosome 18 may be significant. Is it associated with any clinical condition, or is it benign?	Benign	AGACTATTCAGTTTAGACATCTTTCAAAACAAAATCAAGTTTACCTAGTTTGCCTACTGTGTTTAAGACATTGTGTTGGCCACTCTCCGGAATATAAAAAAGTACAGGCTATTAACTCACTTTAAAGGAATTTCCCACAATGTCATCGAGGAACAGGAAATAAAAATGTTGAATGACATTTATGGGACCATCCAAGCTCTCCTCAGAAGAGCACATAGGAGCTGTACTCTTTTGTTTTCTAAGTGGCACATGTATATACAACCTCATGTCTTCAACAATGCTGCCATCTGTTTGATGATAATAACCACATATTTAGGATC...	AGACTATTCAGTTTAGACATCTTTCAAAACAAAATCAAGTTTACCTAGTTTGCCTACTGTGTTTAAGACATTGTGTTGGCCACTCTCCGGAATATAAAAAAGTACAGGCTATTAACTCACTTTAAAGGAATTTCCCACAATGTCATCGAGGAACAGGAAATAAAAATGTTGAATGACATTTATGGGACCATCCAAGCTCTCCTCAGAAGAGCACATAGGAGCTGTACTCTTTTGTTTTCTAAGTGGCACATGTATATACAACCTCATGTCTTCAACAATGCTGCCATCTGTTTGATGATAATAACCACATATTTAGGATC...
Task1_train_46018	Here’s a variant located on Chromosome 18. What is the predicted biological effect — harmless or disease-causing?	Benign	ATATTAGTTGACCTGAAATCTTGATATTGCCTTGTATTAAAATGCTAAGCACTGCTTCATTTTACTAGTGATCTGGGGTATGAAAAGTGCTTTTTGACTTCTGCTGGAAAGCTCTTCAGGTGCAGCTTCCAGGATATTCTTGGGATGTTAACTTCAGCACACATAAGCCTTGCTGTAGATGTGTCAGCTTTGAGGCACAGGGAGACATTTGTTTGTCAGAGAGTAACTGCTTCTGGCAAGGGCATAGGGTGAAACTGGGGATAGCAGAGCTCTTTCTTTGTGGTTGTTCAACCCCCACCCCAAGATTAGTTCAAAGTGAC...	ATATTAGTTGACCTGAAATCTTGATATTGCCTTGTATTAAAATGCTAAGCACTGCTTCATTTTACTAGTGATCTGGGGTATGAAAAGTGCTTTTTGACTTCTGCTGGAAAGCTCTTCAGGTGCAGCTTCCAGGATATTCTTGGGATGTTAACTTCAGCACACATAAGCCTTGCTGTAGATGTGTCAGCTTTGAGGCACAGGGAGACATTTGTTTGTCAGAGAGTAACTGCTTCTGGCAAGGGCATAGGGTGAAACTGGGGATAGCAGAGCTCTTTCTTTGTGGTTGTTCAACCCCCACCCCAAGATTAGTTCAAAGTGAC...
Task1_train_46019	Mutation context: Chromosome 18. Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.	Benign	ATGCTGCCACCTTAGGGTTTTATAGATTCAGTTCCAGAAACTCAAGGCATTTATCTCTTTGGGCTGCTTGTCCTTGCCTGAGCTGAAGCCTGATGCCTCCCATAAGTTGGTATGGCTTTGAAAATGGGTCACTACAGCAGAGGCATGGGCTTATCAAGCAATATGTTCAGCTATGAAATTTGAAGAGGGAGATAATCTGAAAATAAATGACAGCCACCACTTAGATTATGAAATAGAAGTACTTTTTCATAAGTGCTTAATTATTCATACGGTTTTTTATCTTTAACTATGGAGCCAACTCAGCTCCATATGGACTTAAT...	ATGCTGCCACCTTAGGGTTTTATAGATTCAGTTCCAGAAACTCAAGGCATTTATCTCTTTGGGCTGCTTGTCCTTGCCTGAGCTGAAGCCTGATGCCTCCCATAAGTTGGTATGGCTTTGAAAATGGGTCACTACAGCAGAGGCATGGGCTTATCAAGCAATATGTTCAGCTATGAAATTTGAAGAGGGAGATAATCTGAAAATAAATGACAGCCACCACTTAGATTATGAAATAGAAGTACTTTTTCATAAGTGCTTAATTATTCATACGGTTTTTTATCTTTAACTATGGAGCCAACTCAGCTCCATATGGACTTAAT...
Task1_train_46020	A mutation has occurred on Chromosome 18. What is the medical relevance of this mutation?	Benign	TAGTGGTGATGGTTGTACAACAATGTGATTGTCCTTAATGTCATTGAGCTGCACACTTAAAAATGGTTAGCCGGGTGCGGTGGTTCTTGTTTGTAGTCCAAACTATTCAGAAGGCTGAGGGGGAAGGATCACTTGAGCCCAGGAGTTAGGGGCTGCAGTGAGCTATGATTGCGTCACCGCACTCCAGTTCTCCGAACCTCCTTGCTTGGGCTAAGTGAGGAGGAGGAGGAGGAGGAGAAGGATGGAAAGGAGGAGGAGTAGCAGGAGGAGCAGGAGGGCAAGGAGAAGGAGGAAGAGGAGCAGGAGGAGGACAAACAGTT...	TAGTGGTGATGGTTGTACAACAATGTGATTGTCCTTAATGTCATTGAGCTGCACACTTAAAAATGGTTAGCCGGGTGCGGTGGTTCTTGTTTGTAGTCCAAACTATTCAGAAGGCTGAGGGGGAAGGATCACTTGAGCCCAGGAGTTAGGGGCTGCAGTGAGCTATGATTGCGTCACCGCACTCCAGTTCTCCGAACCTCCTTGCTTGGGCTAAGTGAGGAGGAGGAGGAGGAGGAGAAGGATGGAAAGGAGGAGGAGTAGCAGGAGGAGCAGGAGGGCAAGGAGAAGGAGGAAGAGGAGCAGGAGGAGGACAAACAGTT...
Task1_train_46021	Assess the clinical impact of this variant found on Chromosome 18. State whether it’s pathogenic or benign, and the disease if applicable.	Benign	CTTTTGTCTTCTTTGTTGAGTGATCAAAACACACGAGGAGCTCAAGTCACCTTCTCCCTAGCTTCTTGCCAGAAAACTAAAGGGAGCACCTGGAAATAATTCAGAAGGAAAAAATCAAAGATTCATTAGAACTACCCATGAAAAATAACAGTATAAAATAGCATTAATCGATCTAGAACTGCACTAACACAGGAGCCTCTAGCCCCATGTGGCTATATAAATTTAGATGTAGATTAGTTAAAAATTGAGTTCCTCAACCTCTCTAGCCACATCTCAGGTGCTTGATAGCCACACGTGGCTAGGACCCACTGTATTAGACA...	CTTTTGTCTTCTTTGTTGAGTGATCAAAACACACGAGGAGCTCAAGTCACCTTCTCCCTAGCTTCTTGCCAGAAAACTAAAGGGAGCACCTGGAAATAATTCAGAAGGAAAAAATCAAAGATTCATTAGAACTACCCATGAAAAATAACAGTATAAAATAGCATTAATCGATCTAGAACTGCACTAACACAGGAGCCTCTAGCCCCATGTGGCTATATAAATTTAGATGTAGATTAGTTAAAAATTGAGTTCCTCAACCTCTCTAGCCACATCTCAGGTGCTTGATAGCCACACGTGGCTAGGACCCACTGTATTAGACA...
Task1_train_46022	A mutation found on Chromosome 18 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	CCATCACTGGTACCCTTTCTTCCAGTTGATCACATCGGCTACTGAGGCTTGTGCATTCGTCACGTAGTTCTCGTGCCGTGGTTTTCAGCTCCATCAGGTCCTTTAAGGACTTCTCTGCATTGGTTATTCTAGTTAGCCATTTGTCTAATTTTTTTTCAAGCGTTTTAACTTCTTTGCCATTGGTTCGAACTTCCTCCTTTAGCTCAGAGTAGTTTGATCTTCTGAAGCCTTCTCCTCTCAACTCGTCAAAGTCATTCTCCATCCAGCTTTGTTCCGTTGCTGGTGAGGAGCTGCGTTCCTTTGGAGGAGGAGAGGCACTC...	CCATCACTGGTACCCTTTCTTCCAGTTGATCACATCGGCTACTGAGGCTTGTGCATTCGTCACGTAGTTCTCGTGCCGTGGTTTTCAGCTCCATCAGGTCCTTTAAGGACTTCTCTGCATTGGTTATTCTAGTTAGCCATTTGTCTAATTTTTTTTCAAGCGTTTTAACTTCTTTGCCATTGGTTCGAACTTCCTCCTTTAGCTCAGAGTAGTTTGATCTTCTGAAGCCTTCTCCTCTCAACTCGTCAAAGTCATTCTCCATCCAGCTTTGTTCCGTTGCTGGTGAGGAGCTGCGTTCCTTTGGAGGAGGAGAGGCACTC...
Task1_train_46023	Here’s a variant located on Chromosome 18. What is the predicted biological effect — harmless or disease-causing?	Benign	TTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGGACTCCGTTTCAAAAAACAAACAAACAAAAAAAGGAATCAGTTGAAGCCCTCTCTCTAGGAATCTTCTCAATGATTCTGATTTTTTTTTAATTCCTATTTGAATATCTGTCTTATAGGACTCATCTGGTACCTACAAAAATGTGTGATTAGCTCTATGAGTGTTTTCATGCCCTGCAAAACTAGTAAATGTTTGGGACACAGACAGTGTGCTATATATGTCTTTCAATCTTTCTCATTGATAAGCCAACATTACGGACTCAATTAAAATTCTCTCAGTT...	TTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGGACTCCGTTTCAAAAAACAAACAAACAAAAAAAGGAATCAGTTGAAGCCCTCTCTCTAGGAATCTTCTCAATGATTCTGATTTTTTTTTAATTCCTATTTGAATATCTGTCTTATAGGACTCATCTGGTACCTACAAAAATGTGTGATTAGCTCTATGAGTGTTTTCATGCCCTGCAAAACTAGTAAATGTTTGGGACACAGACAGTGTGCTATATATGTCTTTCAATCTTTCTCATTGATAAGCCAACATTACGGACTCAATTAAAATTCTCTCAGTT...
Task1_train_46024	This mutation is located on Chromosome 18. Is it associated with a disease or is it a benign polymorphism?	Benign	CAACTGTCTTACTACAATACAAGATTCTGATAAGACAGAGATTTCAAGGATGAGTCCACCAGCAGCAATAGTCCAAGGCAGAGCATTACAGCCAAATGTAACAAGCGGGACTCTTCCTGGGCTGTCCTTTCCAACTTCCCTAGGGTCTACGCTAGTGGACTACGATTATCGGGATAAGGTACCATTAAGGCAAAGCTTAAAGAAGGTAATGGCCACAGAGTAGAACTGAAAACTGTACTTGGGGGAATCTTTTTAGAAAGCTACTTTATCTAGCCAATCACTGAAAGATAAATTCTCTAACAGGTTAATTACCTTATGTT...	CAACTGTCTTACTACAATACAAGATTCTGATAAGACAGAGATTTCAAGGATGAGTCCACCAGCAGCAATAGTCCAAGGCAGAGCATTACAGCCAAATGTAACAAGCGGGACTCTTCCTGGGCTGTCCTTTCCAACTTCCCTAGGGTCTACGCTAGTGGACTACGATTATCGGGATAAGGTACCATTAAGGCAAAGCTTAAAGAAGGTAATGGCCACAGAGTAGAACTGAAAACTGTACTTGGGGGAATCTTTTTAGAAAGCTACTTTATCTAGCCAATCACTGAAAGATAAATTCTCTAACAGGTTAATTACCTTATGTT...
Task1_train_46025	This sequence change occurs on Chromosome 18. What is the medical significance of this variant — is it benign or linked to a disease?	Benign	TCAGGTGCAAAGGAACAGAAGGCCAATCACAAATACATCGCAAATTCAGAGAAGGGAAGAGTAACTCTAGTAGTCAGCAGTGGGCCAGGCGCGGTGGCTGATGCTTGTAATCCCACCACTTTGGGAGGCCGAGGCAGGTGGATCACGAAGTCAGGAGTTTGAGACCAGCCTGGCCAACACAGTGAAATGCTGTCTCTAACTAAAAATATAAAAATTAGCTGGGCATGGTGGTGGGCGCCTATAATCCCAGCTACTCGGGAGGCTGAAGCAGGAGAATTGCCTGAACCCGGGAGGTAGAGGTTGCAGTGGGCCAAGATTAC...	TCAGGTGCAAAGGAACAGAAGGCCAATCACAAATACATCGCAAATTCAGAGAAGGGAAGAGTAACTCTAGTAGTCAGCAGTGGGCCAGGCGCGGTGGCTGATGCTTGTAATCCCACCACTTTGGGAGGCCGAGGCAGGTGGATCACGAAGTCAGGAGTTTGAGACCAGCCTGGCCAACACAGTGAAATGCTGTCTCTAACTAAAAATATAAAAATTAGCTGGGCATGGTGGTGGGCGCCTATAATCCCAGCTACTCGGGAGGCTGAAGCAGGAGAATTGCCTGAACCCGGGAGGTAGAGGTTGCAGTGGGCCAAGATTAC...
Task1_train_46026	This variant lies on Chromosome 18. Based on this context, is the mutation pathogenic or benign? If pathogenic, what disease does it cause?	Benign	AGTTATATATAGTTAAAGAACAGGGTACTTTATGTCTTCAAGTTCCATATATTTTATAGCAAAGTTGCTTAAATATTAAATATATTAAGCAATTATATTAAGCAATTTAAGGACTTATGTTTAAATATAATAGAAACCAGCTGATTCTTTCCTTTGACTGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTACAACCTCCACCTCCTGGGTTCGAGTGATTCTCCTGCCTCAGGGTCCTAAGTAGCTGGGGCTACAGGTGCCTGCCACCATGGCTGGCTACTTTTTTGTATTTTTTGTT...	AGTTATATATAGTTAAAGAACAGGGTACTTTATGTCTTCAAGTTCCATATATTTTATAGCAAAGTTGCTTAAATATTAAATATATTAAGCAATTATATTAAGCAATTTAAGGACTTATGTTTAAATATAATAGAAACCAGCTGATTCTTTCCTTTGACTGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCAATCTCAGCTCACTACAACCTCCACCTCCTGGGTTCGAGTGATTCTCCTGCCTCAGGGTCCTAAGTAGCTGGGGCTACAGGTGCCTGCCACCATGGCTGGCTACTTTTTTGTATTTTTTGTT...
Task1_train_46027	Given a variant located on Chromosome 18, assess whether it is benign or pathogenic. Indicate the associated disease if pathogenic.	Benign	TTCTGATAGCTACACCAAAACTCGCCTTTGAACAATATGTCTACTCACTAGAAATACAAAGTCACGGACTTCCAATTTCCACCAGAAAAATTTTGTTGAAGTTATCAAATGCTTTGCTTTTGTATAAAATAATCTTAACAGCAAGACAGAACAGACTTAAACTTCTTGGATTTGGGGTGAAAGTTTATTCAATTTTATATTTTGGAGCCAGTGGCTACAAGTTATGTATAAATCAGTCCCTAGAGTAAAAAAACTTGGCTAATTCAAACCCTTAAGTTTATTCTCTTTACAATCTATGATAATAACAAGAAAAAAATCTG...	TTCTGATAGCTACACCAAAACTCGCCTTTGAACAATATGTCTACTCACTAGAAATACAAAGTCACGGACTTCCAATTTCCACCAGAAAAATTTTGTTGAAGTTATCAAATGCTTTGCTTTTGTATAAAATAATCTTAACAGCAAGACAGAACAGACTTAAACTTCTTGGATTTGGGGTGAAAGTTTATTCAATTTTATATTTTGGAGCCAGTGGCTACAAGTTATGTATAAATCAGTCCCTAGAGTAAAAAAACTTGGCTAATTCAAACCCTTAAGTTTATTCTCTTTACAATCTATGATAATAACAAGAAAAAAATCTG...
Task1_train_46028	Chromosome 18 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?	Benign	TGGGACTACAGGCGACCACCACCATGCCCGGCTAATTTTTTTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAGGTTGATCTCGAACTCCTGACTTCAGGTGATGCACCCACCTTGGCCTCCCAAAGTGCTGGAATTACAGACGTCAGCCACTGCACCCGGCCTGGCAGTCAGTATTTTAAAAAGCAACTATTGGCAGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATTACCTAAGGTCGGGAGTTGGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAG...	TGGGACTACAGGCGACCACCACCATGCCCGGCTAATTTTTTTATTTTTAGTAGAGACAGGGTTTCGCCATGTTGGCCAGGTTGATCTCGAACTCCTGACTTCAGGTGATGCACCCACCTTGGCCTCCCAAAGTGCTGGAATTACAGACGTCAGCCACTGCACCCGGCCTGGCAGTCAGTATTTTAAAAAGCAACTATTGGCAGGGCACGGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGCGGATTACCTAAGGTCGGGAGTTGGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAG...
Task1_train_46029	Consider this mutation on Chromosome 18. Is this a benign change or a disease-causing variant?	Benign	AGACAAAGTGCAGTGAGCCCTTCAGACTGGTAAGTTATCTGTGGTGTGTGTCTCCTCTCCAAGAACTGAGGGAGTTGCTAACTCCCAATGTACAGACCAAAGACAGCATTCTTGTCATTTGTTTGGAGTGTCAAGCTTCTAAAAGCTCTTTTGACCAATTATCCTACTTGAACCTAGCACTATTATGTGAAGGAGGGTAAGAAAAATAACCTCTCACCACGTATAGGCATTATATGCCCAAAAAGCTCCCTATGGTCAACAAAAATGCTGTTGGCAAAAGCAAGGTCTCATAGAAAGAAGGAATTTGAAGAAGAACATAA...	AGACAAAGTGCAGTGAGCCCTTCAGACTGGTAAGTTATCTGTGGTGTGTGTCTCCTCTCCAAGAACTGAGGGAGTTGCTAACTCCCAATGTACAGACCAAAGACAGCATTCTTGTCATTTGTTTGGAGTGTCAAGCTTCTAAAAGCTCTTTTGACCAATTATCCTACTTGAACCTAGCACTATTATGTGAAGGAGGGTAAGAAAAATAACCTCTCACCACGTATAGGCATTATATGCCCAAAAAGCTCCCTATGGTCAACAAAAATGCTGTTGGCAAAAGCAAGGTCTCATAGAAAGAAGGAATTTGAAGAAGAACATAA...
Task1_train_46030	Consider this mutation on Chromosome 18. Is this a benign change or a disease-causing variant?	Benign	CCTGAGCACATGGCCTCAGCCTGACTGCCCCTTCCCCAAGAGCAGAGAGGGGGTCCAGGGTTTAGCTGTGGTGCCGGTTTGGCCTGGATGCCCTCTTCATCCTCACAAGCTGGTCTCTGCCCTCTTGATTATGAGTTCCTTAAAGGCGGAGACCATCATTTTCAGTCTCTACCAGGATGGGCATAGCACATAACTGGCCCAAAGGGCAGTGTTGATGGCATCATCGACTCTAGATCATGAGACCTGAGCTCTGTCCTGAGCCCCAGGCTCTGAGGAAGGACCCACATTAAGGTAGGGTCTGGTCCGTCCCCTGCAGCACT...	CCTGAGCACATGGCCTCAGCCTGACTGCCCCTTCCCCAAGAGCAGAGAGGGGGTCCAGGGTTTAGCTGTGGTGCCGGTTTGGCCTGGATGCCCTCTTCATCCTCACAAGCTGGTCTCTGCCCTCTTGATTATGAGTTCCTTAAAGGCGGAGACCATCATTTTCAGTCTCTACCAGGATGGGCATAGCACATAACTGGCCCAAAGGGCAGTGTTGATGGCATCATCGACTCTAGATCATGAGACCTGAGCTCTGTCCTGAGCCCCAGGCTCTGAGGAAGGACCCACATTAAGGTAGGGTCTGGTCCGTCCCCTGCAGCACT...
Task1_train_46031	A mutation on Chromosome 18 is under review. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.	Benign	CCAAAACTTTCTTAATGATAAGAATTATCTAAACCACTTGCTAAATATCCAGATTACCTGGAAATTCTGACTCATTAGGTCTGAATTAGAGCCTAGGAATCTATTTTTATCAAGAATTCCAGGTGATTCTTAACCTTGGTCAAGTTTTAAAAGCCCTTCAATAAATGTTGCTGGAACATTTGCATATCTCCATGGAAAAAAATAAAATTGAATTTCTCCCTCACAAAATTCAATTCCTAGTATTTTAAAAATATAAATGGAAAAATTAAAACAACAATTTTTAGAAAAGGATATAGGAGAATGTCTTCATAGCTCTGAGA...	CCAAAACTTTCTTAATGATAAGAATTATCTAAACCACTTGCTAAATATCCAGATTACCTGGAAATTCTGACTCATTAGGTCTGAATTAGAGCCTAGGAATCTATTTTTATCAAGAATTCCAGGTGATTCTTAACCTTGGTCAAGTTTTAAAAGCCCTTCAATAAATGTTGCTGGAACATTTGCATATCTCCATGGAAAAAAATAAAATTGAATTTCTCCCTCACAAAATTCAATTCCTAGTATTTTAAAAATATAAATGGAAAAATTAAAACAACAATTTTTAGAAAAGGATATAGGAGAATGTCTTCATAGCTCTGAGA...
Task1_train_46032	The following genetic variant occurs on Chromosome 18. Classify its clinical effect — pathogenic or benign — and list any associated condition.	Benign	CTTTTTTCCTGTGTGTGTGTGTATCATATCTGGCATACGTTCCTTTGATTACCAGCCCGTGTGAGGCCAACAAATGCCCTGCTTTATAATGAAAAGTTTTAAGAAAGCTAGCAGACGTCCGTGTGATCTGAACTCAAGGTAGTTAACCCGGTCCTTTCATGGTAATTAGAAAATCTGATTGGCCTCTTTAGACTTCTTGATTCAGAACCTAAATAAGCTGATTAATGTGTCACCATTCTTTCATAGGGGTTCTGGGTGAAAAGTTTGGGAATGATTCTATGTGTTACTTAGGGAAACTATTTTGGCTTAACGCATGTACC...	CTTTTTTCCTGTGTGTGTGTGTATCATATCTGGCATACGTTCCTTTGATTACCAGCCCGTGTGAGGCCAACAAATGCCCTGCTTTATAATGAAAAGTTTTAAGAAAGCTAGCAGACGTCCGTGTGATCTGAACTCAAGGTAGTTAACCCGGTCCTTTCATGGTAATTAGAAAATCTGATTGGCCTCTTTAGACTTCTTGATTCAGAACCTAAATAAGCTGATTAATGTGTCACCATTCTTTCATAGGGGTTCTGGGTGAAAAGTTTGGGAATGATTCTATGTGTTACTTAGGGAAACTATTTTGGCTTAACGCATGTACC...
Task1_train_46033	A variant on Chromosome 18 has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?	Benign	CAGGCTGTTCTTCACCTACTAGGCTCAAGCGAACTGCTTTCCTCCACCTCCCAAAGGAGGATGGCTCACGATTACAAGATCATGCTCAGCCTTTTATTAAAACAACAACAACGGCAGCAACAGCAAACATTTTATGTATTCGGAGTTATCAGTGTCAACTAATGGCTTGTGTGTTTTTGTCTAAGAAGTTCTTATCTACTTGATTTCGAAAAAAAAAAGAAAGGAAAAAGGAAATCTCACATCTTTTTCCTTATTTATGATTACAACTAGGGTGTTTTTAAAAATTATCAGTGAACATCCAAAATAGAATTGTTCCCAAT...	CAGGCTGTTCTTCACCTACTAGGCTCAAGCGAACTGCTTTCCTCCACCTCCCAAAGGAGGATGGCTCACGATTACAAGATCATGCTCAGCCTTTTATTAAAACAACAACAACGGCAGCAACAGCAAACATTTTATGTATTCGGAGTTATCAGTGTCAACTAATGGCTTGTGTGTTTTTGTCTAAGAAGTTCTTATCTACTTGATTTCGAAAAAAAAAAGAAAGGAAAAAGGAAATCTCACATCTTTTTCCTTATTTATGATTACAACTAGGGTGTTTTTAAAAATTATCAGTGAACATCCAAAATAGAATTGTTCCCAAT...
Task1_train_46034	Here is a genetic alteration on Chromosome 18. Based on the data, is it a benign variant or a cause of disease?	Benign	TTTGCCCCTTCTCAGTCAAATTCTCCCCATCTCCATCAGAGTTAGCTACTCTTCTGACTTCCAGCCCCATCAGTTTGTTTTGTCTGAAGTAAACAATTGTTGATGAAAATTTGTTTGGCAAATATGATTGGTCTGGGACAACATTGATGAAGGGAAGTTTGTTTTCCTTCTGCAATCCCCTTTTGATGTTTATTACTCATAACATGCTGAGAGGTATTTTAAGTAGGCAGGGTATATCCAGGACACTGGATTAAAACCATGGGGCCAATCCCTGGATTTCCTACTGTTTCTTAGTTTGAATGGGAGGACTCCTTTCTCTC...	TTTGCCCCTTCTCAGTCAAATTCTCCCCATCTCCATCAGAGTTAGCTACTCTTCTGACTTCCAGCCCCATCAGTTTGTTTTGTCTGAAGTAAACAATTGTTGATGAAAATTTGTTTGGCAAATATGATTGGTCTGGGACAACATTGATGAAGGGAAGTTTGTTTTCCTTCTGCAATCCCCTTTTGATGTTTATTACTCATAACATGCTGAGAGGTATTTTAAGTAGGCAGGGTATATCCAGGACACTGGATTAAAACCATGGGGCCAATCCCTGGATTTCCTACTGTTTCTTAGTTTGAATGGGAGGACTCCTTTCTCTC...
Task1_train_46035	A variant was discovered on Chromosome 18. What is its functional impact — neutral or pathogenic? State the disease if pathogenic.	Benign	GACTCCGTCTCAAAAAAAAAAAAAGTGTACTAGTCCATTTTCATGCTGCTGGTGAAGACATATCCAAGACTGGGAAGAAAAAAAAATTAACTGGACTTACAGTTTCACATGGATGGGGAGCCTCAGAATCATGGCGGGGGGCAAAAGACACTTCTTATATGGTGGCAGCAAGAGAAAATGAGGAAGACGCAAGAAGCGGAAACCCCTGATAAAACCATCAGACCTTGTGAGACTTATTCACTACCATGAGAACAGCATGCGTGGTGGAAACTGCTCACGATTCAAATTATCTCCTACTGGGTCCCTCCCACAACACGTGG...	GACTCCGTCTCAAAAAAAAAAAAAGTGTACTAGTCCATTTTCATGCTGCTGGTGAAGACATATCCAAGACTGGGAAGAAAAAAAAATTAACTGGACTTACAGTTTCACATGGATGGGGAGCCTCAGAATCATGGCGGGGGGCAAAAGACACTTCTTATATGGTGGCAGCAAGAGAAAATGAGGAAGACGCAAGAAGCGGAAACCCCTGATAAAACCATCAGACCTTGTGAGACTTATTCACTACCATGAGAACAGCATGCGTGGTGGAAACTGCTCACGATTCAAATTATCTCCTACTGGGTCCCTCCCACAACACGTGG...
Task1_train_46036	A mutation found on Chromosome 18 may be clinically relevant. Is it pathogenic or benign, and if the former, which disease is implicated?	Benign	GCTATGCTCCTTGTTCTTATCTAGAACCAAAACAAAACACAAAATCTGCAAGTGATCCAACTGACAAGAGGCACACAAAGATCCAATTTTTTTTTTTTTGCAGGGAGGATGCTACTTATTATATCTAAGTTTGAGAGCTATTAACTCCAAGGAGAAACAATCAGAAGGCTCTAGGTATTCTCCAAAAATGTGGCAACTATTCAGAGAGGACAAAGATATCTAAGAATTTTAGCATATATTTATGTAACTGTGTATGTTTAGAGGGCAGACATCATTCAAATGCAAAGAAGTATGCTGAGATTGTGAGAAATGGCACTGTT...	GCTATGCTCCTTGTTCTTATCTAGAACCAAAACAAAACACAAAATCTGCAAGTGATCCAACTGACAAGAGGCACACAAAGATCCAATTTTTTTTTTTTTGCAGGGAGGATGCTACTTATTATATCTAAGTTTGAGAGCTATTAACTCCAAGGAGAAACAATCAGAAGGCTCTAGGTATTCTCCAAAAATGTGGCAACTATTCAGAGAGGACAAAGATATCTAAGAATTTTAGCATATATTTATGTAACTGTGTATGTTTAGAGGGCAGACATCATTCAAATGCAAAGAAGTATGCTGAGATTGTGAGAAATGGCACTGTT...
Task1_train_46037	A mutation is present on Chromosome 18. Based on this information, is the variant pathogenic or benign? Provide the disease if relevant.	Benign	AACTTGGAATGGGACAGAACCTTTTTGCATGATGTAATTTCCAAGCTCTTTCTGGGAAGAAATTAGCATTGATAAAATGCTTAAGCAATTTTCTGACAAACTTTAATGAGATTAAGACCTCTTCTGGGAAGCCAGATACCCACCCACTCAGCTGACTGTCAGTCAGGATCTAATGATCTTGAAACAATCTTTTTTTTTTTTTTATATCCAGTCTAACAGTGATTACTTAATCATCCTGTTTTTCTATAAAATTTTTCTATAGGAGACAATCTCTGAATTAACCCACTAATGCTTCTTTTCTTGTGATTTGCTTGAACTTA...	AACTTGGAATGGGACAGAACCTTTTTGCATGATGTAATTTCCAAGCTCTTTCTGGGAAGAAATTAGCATTGATAAAATGCTTAAGCAATTTTCTGACAAACTTTAATGAGATTAAGACCTCTTCTGGGAAGCCAGATACCCACCCACTCAGCTGACTGTCAGTCAGGATCTAATGATCTTGAAACAATCTTTTTTTTTTTTTTATATCCAGTCTAACAGTGATTACTTAATCATCCTGTTTTTCTATAAAATTTTTCTATAGGAGACAATCTCTGAATTAACCCACTAATGCTTCTTTTCTTGTGATTTGCTTGAACTTA...
Task1_train_46038	A mutation has occurred on Chromosome 18. What is the medical relevance of this mutation?	Benign	ACAAAGATGACTATTACTATAATCACTGTCTGGCTTAATTTTTAAAACAGCAGAACAATTAGTTCAAAAGAGGCACAGGACTTTCAATCATCAAGATAAAGCGGTCATCAGAAAATTGGTTAAATTTCTGCTGCTTATTTTCATTCCTCAAATATTTTAGACTAACTCTCAAGACAGAGTCCTAGGTCTTTGTAAACTAATAGGTAATTACTCCTTGAAAGAAGAGCAAAGTCAGACACTTTACATGCATGATAGTGTTTCATCATCCCTATGAATCTACATGGTAGGGGTTATTATTTCCATTTTACAAAAGCAACAAC...	ACAAAGATGACTATTACTATAATCACTGTCTGGCTTAATTTTTAAAACAGCAGAACAATTAGTTCAAAAGAGGCACAGGACTTTCAATCATCAAGATAAAGCGGTCATCAGAAAATTGGTTAAATTTCTGCTGCTTATTTTCATTCCTCAAATATTTTAGACTAACTCTCAAGACAGAGTCCTAGGTCTTTGTAAACTAATAGGTAATTACTCCTTGAAAGAAGAGCAAAGTCAGACACTTTACATGCATGATAGTGTTTCATCATCCCTATGAATCTACATGGTAGGGGTTATTATTTCCATTTTACAAAAGCAACAAC...
Task1_train_46039	A change on Chromosome 18 is being evaluated. Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.	Benign	GAGCAAGAGAGAGAGGGAAAGTCTACACTGTTGATATAAGCAACCACATTTTATGTAGCTGAGTCAGCTCCATAGCAGCACTGGGTGTAACACCTGACTCCCAGTGGCTCCTCAACAAAGTTACATGAATGAAGAAGTGATTGAGAAAATCACTCATTCACTACAGGCGATATTACCTATTACTAAAGAAAAATAACATGAGATTTGTGGAGGATAATTGGGTAATTAAATCAGGATTTTAAATGAAATACAGCATTTAGATAATATCCAATATTGGCTACAGTAAGCACATTAAAAGTAGTCACCAATAAGTTATACAT...	GAGCAAGAGAGAGAGGGAAAGTCTACACTGTTGATATAAGCAACCACATTTTATGTAGCTGAGTCAGCTCCATAGCAGCACTGGGTGTAACACCTGACTCCCAGTGGCTCCTCAACAAAGTTACATGAATGAAGAAGTGATTGAGAAAATCACTCATTCACTACAGGCGATATTACCTATTACTAAAGAAAAATAACATGAGATTTGTGGAGGATAATTGGGTAATTAAATCAGGATTTTAAATGAAATACAGCATTTAGATAATATCCAATATTGGCTACAGTAAGCACATTAAAAGTAGTCACCAATAAGTTATACAT...