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train · 48.9k rows

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ID stringlengths 13 17	question stringlengths 88 1.13k	answer stringlengths 6 156	reference_sequence stringlengths 4.1k 4.1k	variant_sequence stringlengths 4.1k 4.1k
Task1_train_46100	Here is a variant on Chromosome 18. Please identify whether it is a benign mutation or associated with a disorder.	Benign	GCTTGTTTAAAACAGACTTACTACCAAAAGGTGGATAAGAAGTTTTGCATGAAGCCATCACCTTATTTAGTGCAACCTAGGCCTCAAAAAATTTCAATCTCAAAAAAATTCAATCTGAAAATGATAATTTTTCCTGATCTTATTTCCTACTCAATGAGAATACTATTGTGTCCCTTTAGTAATATAGAAGGTAGAGCATTCTCTACCTGGGTAACTCCAGACTCACTGACTTAATCATAGTTAAGAAGGATAATTCTCAGCATTTAGGTTCATCTGGTACAAGTGCAGAGAAGGGAATTTATGAACTTCACAAGGAGAAT...	GCTTGTTTAAAACAGACTTACTACCAAAAGGTGGATAAGAAGTTTTGCATGAAGCCATCACCTTATTTAGTGCAACCTAGGCCTCAAAAAATTTCAATCTCAAAAAAATTCAATCTGAAAATGATAATTTTTCCTGATCTTATTTCCTACTCAATGAGAATACTATTGTGTCCCTTTAGTAATATAGAAGGTAGAGCATTCTCTACCTGGGTAACTCCAGACTCACTGACTTAATCATAGTTAAGAAGGATAATTCTCAGCATTTAGGTTCATCTGGTACAAGTGCAGAGAAGGGAATTTATGAACTTCACAAGGAGAAT...
Task1_train_46101	Chromosome 18 houses a mutation. Classify its clinical impact — is it pathogenic or benign, and what disease does it lead to if any?	Benign	TGCAGTGGTATTACCTATGCATCACAAGCATCATGAATTATAATTTACTCACTTGTACTCCTAAAATTAACAGTTTTCAATACTTTATTACTATAAATGATAACATATGAATATCTTAATCATCAAAGCATTTTTTAACATTCCATATTATTTAGTGTTCCCTGAAGAACAATGAATAGGTATACAGATACATTTTTTAAAGTAAAAAATTGATATGCACTTATACAATCACTAAAATGTCTATGACTAATTAAGAACTACATATGCGTATCAGAAGGCAACATTTTATGAACTGGAACTATAATGGAAAAGTGGGAACA...	TGCAGTGGTATTACCTATGCATCACAAGCATCATGAATTATAATTTACTCACTTGTACTCCTAAAATTAACAGTTTTCAATACTTTATTACTATAAATGATAACATATGAATATCTTAATCATCAAAGCATTTTTTAACATTCCATATTATTTAGTGTTCCCTGAAGAACAATGAATAGGTATACAGATACATTTTTTAAAGTAAAAAATTGATATGCACTTATACAATCACTAAAATGTCTATGACTAATTAAGAACTACATATGCGTATCAGAAGGCAACATTTTATGAACTGGAACTATAATGGAAAAGTGGGAACA...
Task1_train_46102	This sequence variant lies on Chromosome 18. Is it clinically significant, and what condition might it cause if any?	Benign	TTTTGTAGTCCATCTTGAAAGCAAGAGATGCGTGGGTAAAGCAGCAATTGCAAGGCCTTTAGCAGTGTTTGAGGTCTCTAGATAGATTAGCACAGTTACAGATGAAGGGGAGTTAGACAAAAACTTAAAATTTTCCCATCTCCCCTGACCCCATGATATAACTTCATCTACCACTCTGTAGCAGAAACTTTTTAGCAGACAAAATTTTCAGAAACAAAGGCAAGGGAGGTGATGACATAAAAATAAATCCTGCTAGGCCAAATATGGTGCCATTTTTTAAAACAATCTCTCTGTGCAAACAACACTGAACACATACACGC...	TTTTGTAGTCCATCTTGAAAGCAAGAGATGCGTGGGTAAAGCAGCAATTGCAAGGCCTTTAGCAGTGTTTGAGGTCTCTAGATAGATTAGCACAGTTACAGATGAAGGGGAGTTAGACAAAAACTTAAAATTTTCCCATCTCCCCTGACCCCATGATATAACTTCATCTACCACTCTGTAGCAGAAACTTTTTAGCAGACAAAATTTTCAGAAACAAAGGCAAGGGAGGTGATGACATAAAAATAAATCCTGCTAGGCCAAATATGGTGCCATTTTTTAAAACAATCTCTCTGTGCAAACAACACTGAACACATACACGC...
Task1_train_46103	Chromosome 18 is altered by this variant. Does this mutation result in a disease or is it benign?	Benign	TGGTATACCTTTACAAATTAATTTGTGTGTTGGTATTTGTATGGAAAGTTGATTTTAATTCCTTTACAAAGCTTTGCATTGGGCTAAGACTCTGTGTAGTGTTATCTATGCTGTAAAGTTTCCTCATTTCTAAGCGATAGTCATAACTTCTTCAGTACCCCTTAGATTACCTTGACCATACCTAAGAATCTAACACTGACTTGACACATATTACATAATAAATAAAGTTATTGAACAAATGCACATATTTGTTATAATGTGAATTATGTATCTTTAAAACTTAACTCTGCTTCTCTCACCCACCAGACTGTAAAATCTTT...	TGGTATACCTTTACAAATTAATTTGTGTGTTGGTATTTGTATGGAAAGTTGATTTTAATTCCTTTACAAAGCTTTGCATTGGGCTAAGACTCTGTGTAGTGTTATCTATGCTGTAAAGTTTCCTCATTTCTAAGCGATAGTCATAACTTCTTCAGTACCCCTTAGATTACCTTGACCATACCTAAGAATCTAACACTGACTTGACACATATTACATAATAAATAAAGTTATTGAACAAATGCACATATTTGTTATAATGTGAATTATGTATCTTTAAAACTTAACTCTGCTTCTCTCACCCACCAGACTGTAAAATCTTT...
Task1_train_46104	This mutation is located on Chromosome 18. Is it associated with a disease or is it a benign polymorphism?	Benign	GAGGAACATAAATATATGCTTCATTACACAAATGCAGTTAATTAAAATCTTTTATAAAAATATTTTATTAATTTAACATATGCCATTTGCTTTTTCAGTTTTTCAGTTACTGACAAGACATTCCCACATCCTACACAAGAAAATCTAAAAAATTAAAATTATAAATATGGTGATTCTTATCTTAAACATTCCAATGAAGTTACAAACTTAGTACAATTTTATTATAATTTTCAATGTAAATTCACAGGTCTAAGTCAATACTCAATATCTTTTAAATATTCTATTTTATCACCCAAAACTTAAAATGCACTCAAATGTTA...	GAGGAACATAAATATATGCTTCATTACACAAATGCAGTTAATTAAAATCTTTTATAAAAATATTTTATTAATTTAACATATGCCATTTGCTTTTTCAGTTTTTCAGTTACTGACAAGACATTCCCACATCCTACACAAGAAAATCTAAAAAATTAAAATTATAAATATGGTGATTCTTATCTTAAACATTCCAATGAAGTTACAAACTTAGTACAATTTTATTATAATTTTCAATGTAAATTCACAGGTCTAAGTCAATACTCAATATCTTTTAAATATTCTATTTTATCACCCAAAACTTAAAATGCACTCAAATGTTA...
Task1_train_46105	Given this variant on Chromosome 18, classify it as benign or pathogenic. Include the disorder it may cause if applicable.	Benign	TAGACATTCTGTTTCTTAATCTCAGCCTTGACTATTCCTGTTTTTCTTGTTTTGTTTTGCTTTTCTGCCACTCTTATGTTCTTCACATGCCCAGAGATCTTTGATTTTTCCACTCACAATGATGAATGATATGGATTTATTTGAGGTATTTGGTGTGGGTTTCCTTTGCTGCTGTTTATAAAAACTTGCTTTCCTGCCTCCTCTCTCTTTTGAGTGGTACAGTTCATTGAGAGTTCTGTTGACAATGGAAGGGTTTATTATTGGATTTAATTCCCTGTAGTTTAATGACAAGGTTTCAGAGGTTAAACGGGGGCATTCAG...	TAGACATTCTGTTTCTTAATCTCAGCCTTGACTATTCCTGTTTTTCTTGTTTTGTTTTGCTTTTCTGCCACTCTTATGTTCTTCACATGCCCAGAGATCTTTGATTTTTCCACTCACAATGATGAATGATATGGATTTATTTGAGGTATTTGGTGTGGGTTTCCTTTGCTGCTGTTTATAAAAACTTGCTTTCCTGCCTCCTCTCTCTTTTGAGTGGTACAGTTCATTGAGAGTTCTGTTGACAATGGAAGGGTTTATTATTGGATTTAATTCCCTGTAGTTTAATGACAAGGTTTCAGAGGTTAAACGGGGGCATTCAG...
Task1_train_46106	A variant on Chromosome 18 has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?	Benign	TTGAAGGGTTTAATGTTTTTTCTTAAATGTAATCAGGCCCATTTCAGGGACATTTAGTTTCCAATATTCACTGTAAATACCAGCAACAACAAAACAATGCTGAGACAAATATTCTCATAATCACAACATTTCACACAGCTATGAGTATATCTGTGAAATAAATTCCTGGAAATAGAATGGTTGTATCTGACTTTATGTGCATTTTTAATTAAAAAAATATTGCCAGTGTTTCTCCATGAATGAATCCTTATTTCTCCACATTTTACTGGCAGATTACCTTACCATACTTAGCCTTTGCCAGTCTGAAGACATCTTGATTT...	TTGAAGGGTTTAATGTTTTTTCTTAAATGTAATCAGGCCCATTTCAGGGACATTTAGTTTCCAATATTCACTGTAAATACCAGCAACAACAAAACAATGCTGAGACAAATATTCTCATAATCACAACATTTCACACAGCTATGAGTATATCTGTGAAATAAATTCCTGGAAATAGAATGGTTGTATCTGACTTTATGTGCATTTTTAATTAAAAAAATATTGCCAGTGTTTCTCCATGAATGAATCCTTATTTCTCCACATTTTACTGGCAGATTACCTTACCATACTTAGCCTTTGCCAGTCTGAAGACATCTTGATTT...
Task1_train_46107	A genetic alteration is present on Chromosome 18. Is this variant benign or disease-causing, and if the latter, which condition is involved?	Benign	TGATGCTAAGCTTGCTTCACCATGCAAACCAATAAATTCACTCACAGAATCTTTGATTGATCTGATAGTAGAGTGCTTTCTTGTAAACTGCCTTTCAAGTTTGTTACACTAATATATTTGTGGAAACATTTCATGAATCCAGGTATAAAAAGATCTTTAAGCAAACATAATAAAAATGAGAGTTTACCCTTCTTGCATATACTTAAGCACAACCAGGAAATGGTCGTTTTTATTTTTTCACTCCTGAAAAGGGTTAAAAGAAACTCACAAATTTTATAATTCACAGAAATGTGGGCACTTACCATTTCTGTAATTCACAA...	TGATGCTAAGCTTGCTTCACCATGCAAACCAATAAATTCACTCACAGAATCTTTGATTGATCTGATAGTAGAGTGCTTTCTTGTAAACTGCCTTTCAAGTTTGTTACACTAATATATTTGTGGAAACATTTCATGAATCCAGGTATAAAAAGATCTTTAAGCAAACATAATAAAAATGAGAGTTTACCCTTCTTGCATATACTTAAGCACAACCAGGAAATGGTCGTTTTTATTTTTTCACTCCTGAAAAGGGTTAAAAGAAACTCACAAATTTTATAATTCACAGAAATGTGGGCACTTACCATTTCTGTAATTCACAA...
Task1_train_46108	This mutation on Chromosome 18 may be significant. Is it associated with any clinical condition, or is it benign?	Benign	CTTTTAAAAAAGAGAATGAAGTAGTTCTAATGTCTTTTTTTGACAGTCCAACCTATTAACTCTTTAATAATCCTTCAAAATATTATTCTACAAAAACCTGAAAAAGTTGGATACCTAATATAGACCGTTGCAAAGCTCCCTTTCATTCCCCAAATTCACAACAATAAATGTGACTAGACTGGCATGAGTAGACAAAGGCTAAGGATGAAGAAGGGAATCCCAAAATTGTGTATGACAGAGCACCAATTTATTTCTTGCTGAAGTGGCTGATGAAATAAAGCAAGGTTTCTTGATTCTACAGTTGGCATCAAGAAGCAATC...	CTTTTAAAAAAGAGAATGAAGTAGTTCTAATGTCTTTTTTTGACAGTCCAACCTATTAACTCTTTAATAATCCTTCAAAATATTATTCTACAAAAACCTGAAAAAGTTGGATACCTAATATAGACCGTTGCAAAGCTCCCTTTCATTCCCCAAATTCACAACAATAAATGTGACTAGACTGGCATGAGTAGACAAAGGCTAAGGATGAAGAAGGGAATCCCAAAATTGTGTATGACAGAGCACCAATTTATTTCTTGCTGAAGTGGCTGATGAAATAAAGCAAGGTTTCTTGATTCTACAGTTGGCATCAAGAAGCAATC...
Task1_train_46109	Here is a mutation located on Chromosome 18. Determine whether it’s benign or pathogenic. If the latter, what disease does it cause?	Benign	AGAATTCATAATCTGATATGTTTAAAATTATTTAGAAATATGGAGGCAAATATAAGAGACAGCTTTAAAAGCTGAATATTAATATCTCAGACATGTGTAAGTGACACTGGGACAGGGCTGTCCGCTGGCATCTTTCAGTTGTGTGTGGCATGCACACCTGTTTTCATGAGACTCTTCAAAGCACCAAGGCTTTATGAGCACTGCCTCCTCCGCCTCACCCTTCCCCATTGCTGCCCAGTAAACCTTCCTTCCAGGGTGAACTCAGATGTCACCTGAGATGTAAGGGACTCCCAGACTCATCGGTCAGAATTGCTCCCTGT...	AGAATTCATAATCTGATATGTTTAAAATTATTTAGAAATATGGAGGCAAATATAAGAGACAGCTTTAAAAGCTGAATATTAATATCTCAGACATGTGTAAGTGACACTGGGACAGGGCTGTCCGCTGGCATCTTTCAGTTGTGTGTGGCATGCACACCTGTTTTCATGAGACTCTTCAAAGCACCAAGGCTTTATGAGCACTGCCTCCTCCGCCTCACCCTTCCCCATTGCTGCCCAGTAAACCTTCCTTCCAGGGTGAACTCAGATGTCACCTGAGATGTAAGGGACTCCCAGACTCATCGGTCAGAATTGCTCCCTGT...
Task1_train_46110	A sequence alteration has been identified on Chromosome 18. Is it disease-inducing or harmless?	Benign	GAACAGCTCACGATATAATGAGAGGGATTTCATAAGGTACCATTATGCATGCTGATACTTCTGATGCACTGGCTCATTTTACTTCTTCACGCTGAAGATGCTTCTGGAAAGCAGATGAGCAAGACCTGGCAATGTAGATGGCAACTTAGCCTTGACGTTGGAGGTGCAGAAAGTGCTGCCCCCCACCCGCCAGACCAACCTGCCTGCCCGAGGTATCTGCTTGGGGGATGAGGGTGTCAACTGATAAGGTTTTGATGAACAGACTCTACTTCCCTAAGTTGTAAGGTCATGAAAAACACGAAGGGAGATTCTTGGTTACA...	GAACAGCTCACGATATAATGAGAGGGATTTCATAAGGTACCATTATGCATGCTGATACTTCTGATGCACTGGCTCATTTTACTTCTTCACGCTGAAGATGCTTCTGGAAAGCAGATGAGCAAGACCTGGCAATGTAGATGGCAACTTAGCCTTGACGTTGGAGGTGCAGAAAGTGCTGCCCCCCACCCGCCAGACCAACCTGCCTGCCCGAGGTATCTGCTTGGGGGATGAGGGTGTCAACTGATAAGGTTTTGATGAACAGACTCTACTTCCCTAAGTTGTAAGGTCATGAAAAACACGAAGGGAGATTCTTGGTTACA...
Task1_train_46111	Chromosome 18 is altered by this variant. Does this mutation result in a disease or is it benign?	Benign	TTTTAAAATGTTTATTTCAAGCTGTGAACCTGTGTTTTGATGGGGAAAGTGAGAAAAGAACTTGGTGTTCAGTGTTTCAGGTTATTGCTACCTATCACTCTTTTACAGACAACAGGACAAGATATGTACTTTAAAAGACAATACTTCCACCAAGAGATGAGTGGATAAAATATGCTATATAAGTACAGTGGAATAGTCAGTCATTAAAAGGAATAAATCCTGACTCATGTTGCAATATAAATGAACCCTGAAAACATTATGCTAAATGAAATAAGCCAGACACAAAAAGACAAATATTGTATGATTCCACTTACATGTGG...	TTTTAAAATGTTTATTTCAAGCTGTGAACCTGTGTTTTGATGGGGAAAGTGAGAAAAGAACTTGGTGTTCAGTGTTTCAGGTTATTGCTACCTATCACTCTTTTACAGACAACAGGACAAGATATGTACTTTAAAAGACAATACTTCCACCAAGAGATGAGTGGATAAAATATGCTATATAAGTACAGTGGAATAGTCAGTCATTAAAAGGAATAAATCCTGACTCATGTTGCAATATAAATGAACCCTGAAAACATTATGCTAAATGAAATAAGCCAGACACAAAAAGACAAATATTGTATGATTCCACTTACATGTGG...
Task1_train_46112	A mutation located on Chromosome 18 is being studied. Determine whether it’s pathogenic or benign, and specify the linked disease.	Benign	GACCCACTCTGACCTCCCAGAGCGAAACCCCACTGTTTAAAGGGCACAGAGGGCAAAGCCCTGGTGGCTTCCCTCCTTCCCCCCCTCCATCTCACACCCGTCTTCCTGTAAACCTTTTTGCTTGTAGAGAACCTGCCTAGAAGGTGAGCATGGCCCAAAGTATGCCCCGACCACCACAGAAAGGCATTGCACCCAGCGCAGCTCTGGGGAAAATCGGAGCCTCCACCCAATAGCCCGAAGCCCGCCCTTTCCTTTGGAATCCACTAGTCCTAGGCCTGGCCGTTGAACTTTGGTTTTAATTTGCTCGTGCCACAGGGTGA...	GACCCACTCTGACCTCCCAGAGCGAAACCCCACTGTTTAAAGGGCACAGAGGGCAAAGCCCTGGTGGCTTCCCTCCTTCCCCCCCTCCATCTCACACCCGTCTTCCTGTAAACCTTTTTGCTTGTAGAGAACCTGCCTAGAAGGTGAGCATGGCCCAAAGTATGCCCCGACCACCACAGAAAGGCATTGCACCCAGCGCAGCTCTGGGGAAAATCGGAGCCTCCACCCAATAGCCCGAAGCCCGCCCTTTCCTTTGGAATCCACTAGTCCTAGGCCTGGCCGTTGAACTTTGGTTTTAATTTGCTCGTGCCACAGGGTGA...
Task1_train_46113	Assess the clinical impact of this variant found on Chromosome 18. State whether it’s pathogenic or benign, and the disease if applicable.	Benign	GTAAATGTTGTGTTTTGTATTTTCTTAACATTTATTCAGATTCATAGGAGAAACATGTTCACCAACTTCTTCAACACTGAGTACTGCAAATGCATTTTCATGTTTTCACTTGGACTGAAGCATCTGATTGCTCTAAAGTTCTCAACTACTTCTTTGCTCATTATTTATTCTTACCTTGAGCCTATTAAATTTTGGTAACAGTAGTGTGTTATGGCTTCTACTCTAAATCACTTCTTTTTGCTATATACATATGTGTGTGTGTGTGTGTGTGTGTTTTGTTTTTTTTTTTAACCAAACCCTCTTTTCAGCAATAATCTCAT...	GTAAATGTTGTGTTTTGTATTTTCTTAACATTTATTCAGATTCATAGGAGAAACATGTTCACCAACTTCTTCAACACTGAGTACTGCAAATGCATTTTCATGTTTTCACTTGGACTGAAGCATCTGATTGCTCTAAAGTTCTCAACTACTTCTTTGCTCATTATTTATTCTTACCTTGAGCCTATTAAATTTTGGTAACAGTAGTGTGTTATGGCTTCTACTCTAAATCACTTCTTTTTGCTATATACATATGTGTGTGTGTGTGTGTGTGTGTTTTGTTTTTTTTTTTAACCAAACCCTCTTTTCAGCAATAATCTCAT...
Task1_train_46114	This mutation on Chromosome 18 may be significant. Is it associated with any clinical condition, or is it benign?	Benign	TATAAAAGTCCCAATACCAGAATCAATTTTCCATTGTATTCATTGTGACTAACAAAAAGAGTCTGAGGATGTGTTTTCACCTCTATCTGTGAGTGGGGCGGAAGTTGCTGGGTGTCACACATGGAAGTGGGGTGAGAGCATGCGCGCTGGAGCCTGTGTGGCCTCTTGGTCAGGTGCTTGTGGAGGTTTAGCTGATGCCCTTTGGCTGTTTCTGGACTAAGATCATCAACTTTCTTAAACTGAATCTGGTTTTCCTTGGGCTCTGTCGTCTGTGTTGTGGGTTTGTGGTGGTGGACACAGGATGTGACATTCTTGCTGGG...	TATAAAAGTCCCAATACCAGAATCAATTTTCCATTGTATTCATTGTGACTAACAAAAAGAGTCTGAGGATGTGTTTTCACCTCTATCTGTGAGTGGGGCGGAAGTTGCTGGGTGTCACACATGGAAGTGGGGTGAGAGCATGCGCGCTGGAGCCTGTGTGGCCTCTTGGTCAGGTGCTTGTGGAGGTTTAGCTGATGCCCTTTGGCTGTTTCTGGACTAAGATCATCAACTTTCTTAAACTGAATCTGGTTTTCCTTGGGCTCTGTCGTCTGTGTTGTGGGTTTGTGGTGGTGGACACAGGATGTGACATTCTTGCTGGG...
Task1_train_46115	Consider this mutation on Chromosome 18. Is this a benign change or a disease-causing variant?	Benign	GCAGGCCAGCCTCTTTTCTTCCTGTTCCTTCTGGTGTAAAGGCCTTCTGCTTTCATTTCTGAATTTCCACATGTGCCTGCACGGGAGGCTTTGACCAGATGAGGAATCCTCCCACCCTCATGCTGGGCCCCTCTGGGCTAAGTTCCAGGCTCTTCTCATCGAAGCCCTTCCAACTGGATCATTGCATCTGTGTTCAAACCTTTCCTGGCCCAGTGTCAGTTGTGTTCATTACTGTGCAAAACTGAAACTGACTTTACTTAAAGCAACATTTTTTATGAGATGTAATTCCATGTCATTGTCCTTGTCACGGTGGAATTACT...	GCAGGCCAGCCTCTTTTCTTCCTGTTCCTTCTGGTGTAAAGGCCTTCTGCTTTCATTTCTGAATTTCCACATGTGCCTGCACGGGAGGCTTTGACCAGATGAGGAATCCTCCCACCCTCATGCTGGGCCCCTCTGGGCTAAGTTCCAGGCTCTTCTCATCGAAGCCCTTCCAACTGGATCATTGCATCTGTGTTCAAACCTTTCCTGGCCCAGTGTCAGTTGTGTTCATTACTGTGCAAAACTGAAACTGACTTTACTTAAAGCAACATTTTTTATGAGATGTAATTCCATGTCATTGTCCTTGTCACGGTGGAATTACT...
Task1_train_46116	A mutation on Chromosome 18 is under review. Please evaluate whether this mutation is benign or pathogenic and specify the disease if necessary.	Benign	AGCTAGCATTATTGCCTAGTGAACGGAAAGTCTTAATGCTAAAGTGACCATACCGAAGATTGCTCTGGTGCCACATTGAAGATGAAGAGGAACAGAGAAAGACCAGCTGGGCAGGAAGGATGGGAGGGAATGAACTGAAGAATCAACTTCAAAAAAGCCCAACCTGTAGAAATTGGTAATTGATTGGATATGGCGTATATAGGAGAAATCATGCTGGTAGGAAGTAATTGCAGAAGAGATTGAGTTTGGGTCTAGATCTCCTGAGTTTTGGAAACTGGAAGCATGCTCAAGTGGAAGGCACCGTAAGCATTCCAGAGTTT...	AGCTAGCATTATTGCCTAGTGAACGGAAAGTCTTAATGCTAAAGTGACCATACCGAAGATTGCTCTGGTGCCACATTGAAGATGAAGAGGAACAGAGAAAGACCAGCTGGGCAGGAAGGATGGGAGGGAATGAACTGAAGAATCAACTTCAAAAAAGCCCAACCTGTAGAAATTGGTAATTGATTGGATATGGCGTATATAGGAGAAATCATGCTGGTAGGAAGTAATTGCAGAAGAGATTGAGTTTGGGTCTAGATCTCCTGAGTTTTGGAAACTGGAAGCATGCTCAAGTGGAAGGCACCGTAAGCATTCCAGAGTTT...
Task1_train_46117	A change on Chromosome 18 is being evaluated. Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.	Benign	GTGTTATGAGGGTTCCAGTTTTTCCACATTCTTGCCAACGCTTGTTATCTGATTTTTTGAGTATAGCTATCTTAGTGGGTTTGAAATGGTATCTCCTTGTGGGTTTGATTTGCATTTCTTTAGTGACTACTGATGTAGAGTATCTTTTCATATGTGTATTATGTATATTTTCTATGAAGAAATGTATTTCATATTCTGTGCTCATTTTAAATTGATTTATCTTACTATTGAGAATAAAAGTTTTAAAAATATATTTTAGATGCAAGTCCCTTATCAGATATCTGATTTGCAAAAATGTGTTCCCATTCTGTGGGCTCTGT...	GTGTTATGAGGGTTCCAGTTTTTCCACATTCTTGCCAACGCTTGTTATCTGATTTTTTGAGTATAGCTATCTTAGTGGGTTTGAAATGGTATCTCCTTGTGGGTTTGATTTGCATTTCTTTAGTGACTACTGATGTAGAGTATCTTTTCATATGTGTATTATGTATATTTTCTATGAAGAAATGTATTTCATATTCTGTGCTCATTTTAAATTGATTTATCTTACTATTGAGAATAAAAGTTTTAAAAATATATTTTAGATGCAAGTCCCTTATCAGATATCTGATTTGCAAAAATGTGTTCCCATTCTGTGGGCTCTGT...
Task1_train_46118	An alteration has been detected on Chromosome 18. Is it pathogenic, and if so, what disease is involved?	Benign	TAGGACTTGGGCTTCTGTTAGAGGTTAAGGAGGGGAAGGCCTCACTTCTAGACTTGCATCACAGCAGTTTTGTTTTAATATATTTTACAGAGTAGGAGCTCATTGAAATGTTTTTTGAAAGGAGAGCTTCTCTTTTTGTTTTTTTTTTAAAAGGGTAGTAAATTGAAGTATGCTGGTACAGAGAATTGAAATATGGGAGTTTTTCTGCAAGCTTGTTGAGAAATCACTTTTTCTACCAAAGATACCATAGTATTTCTTCTGGAGTCAACAATAGGGTGACATGGTGTTCCTAAAATCCTACTTCATACTTTTTGATAAAA...	TAGGACTTGGGCTTCTGTTAGAGGTTAAGGAGGGGAAGGCCTCACTTCTAGACTTGCATCACAGCAGTTTTGTTTTAATATATTTTACAGAGTAGGAGCTCATTGAAATGTTTTTTGAAAGGAGAGCTTCTCTTTTTGTTTTTTTTTTAAAAGGGTAGTAAATTGAAGTATGCTGGTACAGAGAATTGAAATATGGGAGTTTTTCTGCAAGCTTGTTGAGAAATCACTTTTTCTACCAAAGATACCATAGTATTTCTTCTGGAGTCAACAATAGGGTGACATGGTGTTCCTAAAATCCTACTTCATACTTTTTGATAAAA...
Task1_train_46119	This alteration occurs on Chromosome 18. Is it associated with a disease or is it a benign variant?	Benign	TCCTAAAAAATCACGTACAATGGCAACAAAAAATGTTCACTCAAAACCAAGAACTTCTAAATCAATAGCAAAGAATAGTGATTCAAAAGGATTACGAAATGTGGGAAGCACGTTTAAAGATTTCAGAGGAAGTATTTCTAAACAAAGTGGTAGTAGCAGTGAGCTTCTTGTTGAAATGATGCCTTCCAGAAATACTTTGTCACAGGAAGTAGAGATTGTTGAAGAACATGTTACTTCCCTTGGTCTAGCTCAGAATCCTGAAAACCAGAGTAGAAAGCTAGACACCTTAGTAACCTCAGAGGGTCTCTTAGAGAAATTGG...	TCCTAAAAAATCACGTACAATGGCAACAAAAAATGTTCACTCAAAACCAAGAACTTCTAAATCAATAGCAAAGAATAGTGATTCAAAAGGATTACGAAATGTGGGAAGCACGTTTAAAGATTTCAGAGGAAGTATTTCTAAACAAAGTGGTAGTAGCAGTGAGCTTCTTGTTGAAATGATGCCTTCCAGAAATACTTTGTCACAGGAAGTAGAGATTGTTGAAGAACATGTTACTTCCCTTGGTCTAGCTCAGAATCCTGAAAACCAGAGTAGAAAGCTAGACACCTTAGTAACCTCAGAGGGTCTCTTAGAGAAATTGG...
Task1_train_46120	A mutation on Chromosome 18 is under examination. Does this mutation cause a disorder, or is it a benign change?	Benign	AATATCTTTTTAAAGATCATCTAACTGCTGGGGAGGCTGTCTCTTTGAAGATGATTTACTTCTTCTAACTGGGTTTCATTTTTCTCTCCTAGCTTATGTTCCTGAGGAAGAATTGAAGGCAGCAGAAATAGATGAAGAGCACGTGGAGGATGACGGGCTGTCTTTGGACATTCAGGAAAGTGAGTACATGTGCAATGAAGAGACGGAGATCAAAGAGGCGCAGAGCTACCAGAACTCCCCAGTCAGCTCTGCGACTAACCAGGACGCCGGCTACGGGTCGCCCTTCAGTGAGAGCAGCGACCAGCTAGCCCATTTCAAAG...	AATATCTTTTTAAAGATCATCTAACTGCTGGGGAGGCTGTCTCTTTGAAGATGATTTACTTCTTCTAACTGGGTTTCATTTTTCTCTCCTAGCTTATGTTCCTGAGGAAGAATTGAAGGCAGCAGAAATAGATGAAGAGCACGTGGAGGATGACGGGCTGTCTTTGGACATTCAGGAAAGTGAGTACATGTGCAATGAAGAGACGGAGATCAAAGAGGCGCAGAGCTACCAGAACTCCCCAGTCAGCTCTGCGACTAACCAGGACGCCGGCTACGGGTCGCCCTTCAGTGAGAGCAGCGACCAGCTAGCCCATTTCAAAG...
Task1_train_46121	Consider a variant on Chromosome 18. Determine its clinical classification and disease relevance.	Benign	CAGATCCATACTGGGGACAGATTCCTGGGTGTGGGGGACCCTGGGCACAGGGACCCTGGGCAAGGGCACAAGGCCACCCGGGTGTGGAGTCCTGAGTCCCAGGGTTACCTGAGCATAGGCCTAGCTGAGTAAAGGGCCACCGGGTAAGGGGCTAATGAGCGAGCCTACTTGAGTATACGTTTACCTGGAAGCAGGAACCCCCTGAGCCTGGGATCCCAGGACCCAGGCCACCTGGGTACACTTGCTCACCTGGTGCAGGTTCAGGGGCGCCCTCCTCACCACTGTCTTCGGCAGCCTCGTCGGCCAGGCCAGAGCCCGGG...	CAGATCCATACTGGGGACAGATTCCTGGGTGTGGGGGACCCTGGGCACAGGGACCCTGGGCAAGGGCACAAGGCCACCCGGGTGTGGAGTCCTGAGTCCCAGGGTTACCTGAGCATAGGCCTAGCTGAGTAAAGGGCCACCGGGTAAGGGGCTAATGAGCGAGCCTACTTGAGTATACGTTTACCTGGAAGCAGGAACCCCCTGAGCCTGGGATCCCAGGACCCAGGCCACCTGGGTACACTTGCTCACCTGGTGCAGGTTCAGGGGCGCCCTCCTCACCACTGTCTTCGGCAGCCTCGTCGGCCAGGCCAGAGCCCGGG...
Task1_train_46122	This sequence change occurs on Chromosome 18. What is the medical significance of this variant — is it benign or linked to a disease?	Benign	GCACTTAGGTACCAAACACAGTACCAAACATAGTACTGCACACAGGTACCAAACAGTACTGCCCACTGGTACCGCATAAAGTACCAAACATAGTACTGCACACAGGTACCAAACAGTACTGCCCACTGGTACCTCATATAGTACCAAACACAGTACTGCACACAGGTACCACATACAGTACCAAACAGTACTGCACACAGGCATCATGCATGCTACCAAACACAGTAATAAACAGTACTGCACACAAGTAGTACATAGAGTACCAAACACAGTACTGCGCTCAGGTACTGCATACAGTACTAAACACAGTACTACACACA...	GCACTTAGGTACCAAACACAGTACCAAACATAGTACTGCACACAGGTACCAAACAGTACTGCCCACTGGTACCGCATAAAGTACCAAACATAGTACTGCACACAGGTACCAAACAGTACTGCCCACTGGTACCTCATATAGTACCAAACACAGTACTGCACACAGGTACCACATACAGTACCAAACAGTACTGCACACAGGCATCATGCATGCTACCAAACACAGTAATAAACAGTACTGCACACAAGTAGTACATAGAGTACCAAACACAGTACTGCGCTCAGGTACTGCATACAGTACTAAACACAGTACTACACACA...
Task1_train_46123	The following genetic variant occurs on Chromosome 18. Classify its clinical effect — pathogenic or benign — and list any associated condition.	Benign	TCTTTTTCAGGAAGGTGTCTTTATTTCTTTTAATACATTAGTGAGAAATTTGAGGAACTGTTTTTAGGTACAGCTTTGCTTTTAAATGAGATGCAGTGGTTTTTAGATGCTGTTGGACAGCAAAAATTAACATTGAATTTTATATAATTCAGTAACCTTCCTCCTTTTAAAATTATATTTATATCTGAATTTTAATGTTGGAAATACAGAAGAGTTACAATATTTTAGGAAAGCTATTTGGTTGATCCAATTAACTTTCTCGAGTACACTTAATATAAGAAGTATTGTGCTAGGTCCTATCAAAACTACATAGTGCATGG...	TCTTTTTCAGGAAGGTGTCTTTATTTCTTTTAATACATTAGTGAGAAATTTGAGGAACTGTTTTTAGGTACAGCTTTGCTTTTAAATGAGATGCAGTGGTTTTTAGATGCTGTTGGACAGCAAAAATTAACATTGAATTTTATATAATTCAGTAACCTTCCTCCTTTTAAAATTATATTTATATCTGAATTTTAATGTTGGAAATACAGAAGAGTTACAATATTTTAGGAAAGCTATTTGGTTGATCCAATTAACTTTCTCGAGTACACTTAATATAAGAAGTATTGTGCTAGGTCCTATCAAAACTACATAGTGCATGG...
Task1_train_46124	A mutation on Chromosome 18 has been found. Is it harmful or harmless? What disease, if any, does it cause?	Benign	TACAAAACAAAAATCTTTGGATTAATGAGGTTATTATAAATCGAGCAACTCTATTTAGCCTCTTTTTCTGTTCATCAGCAGAATCATTTTCCCAGTGTCAGCATCTGGGGTCACTGAGACGGGCCAGCCAGTCCCACTTCCACATGCGGGTTCCTGGGGCTTCTCGCACTGGTTGTGTTGGAGGAAGTTAAACATTTTCTCGGACGTGGTGTTGCTCCCTCCCTGGGAGGGAGACCAGTCACGTCGCCTGGGAACCCTCTGGGAGAAGAGGATCTGGCCTTGCAGGGCTGGGTCCCCGGCACAGAAGCAAGAGACCAGAC...	TACAAAACAAAAATCTTTGGATTAATGAGGTTATTATAAATCGAGCAACTCTATTTAGCCTCTTTTTCTGTTCATCAGCAGAATCATTTTCCCAGTGTCAGCATCTGGGGTCACTGAGACGGGCCAGCCAGTCCCACTTCCACATGCGGGTTCCTGGGGCTTCTCGCACTGGTTGTGTTGGAGGAAGTTAAACATTTTCTCGGACGTGGTGTTGCTCCCTCCCTGGGAGGGAGACCAGTCACGTCGCCTGGGAACCCTCTGGGAGAAGAGGATCTGGCCTTGCAGGGCTGGGTCCCCGGCACAGAAGCAAGAGACCAGAC...
Task1_train_46125	Assess the clinical impact of this variant found on Chromosome 18. State whether it’s pathogenic or benign, and the disease if applicable.	Benign	ACATTCCAAGGTCTTACCTTTCCCTGCGACGGGGGTGGTGTGCGAGGCGTCACCTGGAAAGACACAGAGAACCGTGGGCTGCACTGGGAGCCCTGTGCCGCCGTCCATTTCCTAACGGGCTCCTGCCTGCTGAGGGTGGCTAGCATCCATCAGCTGCCAGAAGCACCCGGGTGCCCAGCCTCCCCACTTCTGTCCTAGTTGGTGAAGAAGTATAGACCTGAGATTGAAAATATTCTAGATGATGCAGATCTCCCAGAGCACTCAGGAAGTGTTTCAGAGGATGGAAAACACCTCCCAGAGGCTCCGTAGCTGGGGAATGG...	ACATTCCAAGGTCTTACCTTTCCCTGCGACGGGGGTGGTGTGCGAGGCGTCACCTGGAAAGACACAGAGAACCGTGGGCTGCACTGGGAGCCCTGTGCCGCCGTCCATTTCCTAACGGGCTCCTGCCTGCTGAGGGTGGCTAGCATCCATCAGCTGCCAGAAGCACCCGGGTGCCCAGCCTCCCCACTTCTGTCCTAGTTGGTGAAGAAGTATAGACCTGAGATTGAAAATATTCTAGATGATGCAGATCTCCCAGAGCACTCAGGAAGTGTTTCAGAGGATGGAAAACACCTCCCAGAGGCTCCGTAGCTGGGGAATGG...
Task1_train_46126	This alteration on Chromosome 18 may affect genome function. Does it lead to a disease or is it benign?	Benign	AGGAGGATTAAAAGTCAAACAAAATAACTTACAATTAACATTTACAAATTCAGGCAGAAATAGAAACATCACAAGAAAGTTTGGTCTCTTGTTTTTTTTTTTTCTTTTTTCCCCAGCGTTTCGTGGCTACCTTTAATCAGCGCACACAGCTAGGACCACCACTGACCAAACTCAAACCCGACGTTTTAAATCATGGAGGAGCCATGAGCTACCAGGTGTAAAACAAGCGACGTGTCTTACACTTTCTTATCTTTGGGCAGAACTGTGATACTTCTGGAGGATTTTCAAAGAGGATTTGAACAAAATAGCTTTGTTTAACC...	AGGAGGATTAAAAGTCAAACAAAATAACTTACAATTAACATTTACAAATTCAGGCAGAAATAGAAACATCACAAGAAAGTTTGGTCTCTTGTTTTTTTTTTTTCTTTTTTCCCCAGCGTTTCGTGGCTACCTTTAATCAGCGCACACAGCTAGGACCACCACTGACCAAACTCAAACCCGACGTTTTAAATCATGGAGGAGCCATGAGCTACCAGGTGTAAAACAAGCGACGTGTCTTACACTTTCTTATCTTTGGGCAGAACTGTGATACTTCTGGAGGATTTTCAAAGAGGATTTGAACAAAATAGCTTTGTTTAACC...
Task1_train_46127	A change on Chromosome 18 is being evaluated. Identify whether the variant is neutral or disease-linked. Mention the disease if applicable.	Benign	AGGATTTGAACAAAATAGCTTTGTTTAACCCGGAGTTAGTAGAAGTGGTTGTTTCAGAACAGTTAACTCCCTGGGAGTTACTCCAGCATTTACAGCAATTTTTAACTGTGTTCTTTTCCCTCAGATTTCTGTTTTTCCCACAAAAAAAAAAAAAAAACAAAACCTCAAAAAACAAAACACACACACGCGCGCACGCACGCGCACACACACACACACACACACACACACACACACACCCCCTCTGCCGCGGTACCCTTCCCCTGGCCTTCCTCCACTGAAGGGCGGCTGGGTTCCAGGCTCTCAGCCGTGACCACAGCCCC...	AGGATTTGAACAAAATAGCTTTGTTTAACCCGGAGTTAGTAGAAGTGGTTGTTTCAGAACAGTTAACTCCCTGGGAGTTACTCCAGCATTTACAGCAATTTTTAACTGTGTTCTTTTCCCTCAGATTTCTGTTTTTCCCACAAAAAAAAAAAAAAAACAAAACCTCAAAAAACAAAACACACACACGCGCGCACGCACGCGCACACACACACACACACACACACACACACACACACCCCCTCTGCCGCGGTACCCTTCCCCTGGCCTTCCTCCACTGAAGGGCGGCTGGGTTCCAGGCTCTCAGCCGTGACCACAGCCCC...
Task1_train_46128	Chromosome 18 carries this variant. Does this mutation lead to a specific disease, or is it non-pathogenic?	Benign	AAACACACACACGCGCGCACGCACGCGCACACACACACACACACACACACACACACACACACCCCCTCTGCCGCGGTACCCTTCCCCTGGCCTTCCTCCACTGAAGGGCGGCTGGGTTCCAGGCTCTCAGCCGTGACCACAGCCCCGGCCCCAACCGCTAAGGAGGTGCTCATCACTGGAGGTGGCCGCCAGGGAGCTCAGTGCGGGACCTGCTCAATCCATACGGTCCCCTGACTTGAGGGTGACCGTCCTTAAACTGTCCCCCGGAGCTTCGCCAGATAAAATGTCCAAAACACACACTGGAGTTCCCTGACGTTTCC...	AAACACACACACGCGCGCACGCACGCGCACACACACACACACACACACACACACACACACACCCCCTCTGCCGCGGTACCCTTCCCCTGGCCTTCCTCCACTGAAGGGCGGCTGGGTTCCAGGCTCTCAGCCGTGACCACAGCCCCGGCCCCAACCGCTAAGGAGGTGCTCATCACTGGAGGTGGCCGCCAGGGAGCTCAGTGCGGGACCTGCTCAATCCATACGGTCCCCTGACTTGAGGGTGACCGTCCTTAAACTGTCCCCCGGAGCTTCGCCAGATAAAATGTCCAAAACACACACTGGAGTTCCCTGACGTTTCC...
Task1_train_46129	Here’s a variant located on Chromosome 18. What is the predicted biological effect — harmless or disease-causing?	Benign	TGCCCCCATGATTCAATTACCTCTCACTGGGTCCCTCCCATTATGTGTGGAGATTATGGGAATGACAATTCAAGATGAGAGCTGGGTGGGGTCACAGCCAAACCATATCAGTGGGATTGCTGCCAGCTCACGCTCTGATGCTTCCCCTCCCAATGTCCAAGCATGCTCTAAAATATTACAGCCTGGACTATGTCTGAGAGAAAGAAGTTACTTGAGTCCTAACCTTTGGCCAAGAGGCTGAAAGGTGCACCTCTTTGCGCTTAATGTTCCTTTTTTCCTATGAGAAGTAAACTTGCTGGTGAAGTGAACAGAAAGCTGAA...	TGCCCCCATGATTCAATTACCTCTCACTGGGTCCCTCCCATTATGTGTGGAGATTATGGGAATGACAATTCAAGATGAGAGCTGGGTGGGGTCACAGCCAAACCATATCAGTGGGATTGCTGCCAGCTCACGCTCTGATGCTTCCCCTCCCAATGTCCAAGCATGCTCTAAAATATTACAGCCTGGACTATGTCTGAGAGAAAGAAGTTACTTGAGTCCTAACCTTTGGCCAAGAGGCTGAAAGGTGCACCTCTTTGCGCTTAATGTTCCTTTTTTCCTATGAGAAGTAAACTTGCTGGTGAAGTGAACAGAAAGCTGAA...
Task1_train_46130	This sequence variant lies on Chromosome 18. Is it clinically significant, and what condition might it cause if any?	Benign	GTAAGTAACCTTACCTTAAATCTGGAATGTCTCCGCGCTGCGTAAAGATGAGAAATCCGCGTGGTGGGGACCACACCGGCCACAGCGCGGCCCCCTGTCAGGTGTTGATGTGAGTTTGAAAGGTTACAGATTAGTTTAGCAATGTTAAGTGAACTGGCAAAGGCATCTCTAATTTTGCTGGAAATGAGGAAGCCGGATGGTAAAGGGGAATCCTAATGAGCCCATCGAAAGCCGGCTTTGTACTCAACAGACAGGGTAGCCGCAGATTGTATGAAAATATTGGAAATCAATGGCTTCTATGGAATTTCATTAAGAAGCAG...	GTAAGTAACCTTACCTTAAATCTGGAATGTCTCCGCGCTGCGTAAAGATGAGAAATCCGCGTGGTGGGGACCACACCGGCCACAGCGCGGCCCCCTGTCAGGTGTTGATGTGAGTTTGAAAGGTTACAGATTAGTTTAGCAATGTTAAGTGAACTGGCAAAGGCATCTCTAATTTTGCTGGAAATGAGGAAGCCGGATGGTAAAGGGGAATCCTAATGAGCCCATCGAAAGCCGGCTTTGTACTCAACAGACAGGGTAGCCGCAGATTGTATGAAAATATTGGAAATCAATGGCTTCTATGGAATTTCATTAAGAAGCAG...
Task1_train_46131	Consider this mutation on Chromosome 18. Is this a benign change or a disease-causing variant?	Benign	GAAATGAGGAAGCCGGATGGTAAAGGGGAATCCTAATGAGCCCATCGAAAGCCGGCTTTGTACTCAACAGACAGGGTAGCCGCAGATTGTATGAAAATATTGGAAATCAATGGCTTCTATGGAATTTCATTAAGAAGCAGGATCCACAATTGATAGGGCCTCATAATTTGATGGATTGGGCTAAGAAAATGATTAGCTAGCTAGAAAGAGTCATAGAATACGCACGCTGGGACGTCAGAAATGTCGAAGTGGGGTAATTTGTACAAAATAAAAAATATTGATTTTACTCGTGCAAAATTTTGAGACGGAGGGCGGGCGCC...	GAAATGAGGAAGCCGGATGGTAAAGGGGAATCCTAATGAGCCCATCGAAAGCCGGCTTTGTACTCAACAGACAGGGTAGCCGCAGATTGTATGAAAATATTGGAAATCAATGGCTTCTATGGAATTTCATTAAGAAGCAGGATCCACAATTGATAGGGCCTCATAATTTGATGGATTGGGCTAAGAAAATGATTAGCTAGCTAGAAAGAGTCATAGAATACGCACGCTGGGACGTCAGAAATGTCGAAGTGGGGTAATTTGTACAAAATAAAAAATATTGATTTTACTCGTGCAAAATTTTGAGACGGAGGGCGGGCGCC...
Task1_train_46132	The following genetic variant occurs on Chromosome 18. Classify its clinical effect — pathogenic or benign — and list any associated condition.	Benign	AGTGAGGGTCAGGAGATGGTGTTGTTGCTGTCAGTTATTGAGTGAGGGTGAGAAGACGGTGTTGTCCCTGTCAGTAGTTGAGGGTCAGGAGAAGGTGTTGTCATTGTCAGTTGTTGAGTGAGGGTGAAGAAATGTTGTTGTCACTTTCAGTTGCTGAGTGAGGGTCAGAAGATGTTGTCACTGTCAGGTGTTGACTGAGGGTCAGATGGTGTTGTCACTGTCAGTAGTTGAGTGAGGGTGAGAAGATGCTGTTGTCACTGTCAGTAGTTGAGTGAGGGTGAGGAGACGGCGTTATCACTGTCAGGTACTGAGTGAGGGTG...	AGTGAGGGTCAGGAGATGGTGTTGTTGCTGTCAGTTATTGAGTGAGGGTGAGAAGACGGTGTTGTCCCTGTCAGTAGTTGAGGGTCAGGAGAAGGTGTTGTCATTGTCAGTTGTTGAGTGAGGGTGAAGAAATGTTGTTGTCACTTTCAGTTGCTGAGTGAGGGTCAGAAGATGTTGTCACTGTCAGGTGTTGACTGAGGGTCAGATGGTGTTGTCACTGTCAGTAGTTGAGTGAGGGTGAGAAGATGCTGTTGTCACTGTCAGTAGTTGAGTGAGGGTGAGGAGACGGCGTTATCACTGTCAGGTACTGAGTGAGGGTG...
Task1_train_46133	This variant is present on Chromosome 18. Is the change likely to result in a pathogenic outcome?	Benign	TCTTTCTCAGTGAGAACAGACTGAGTCTGCAGAAATTGAGCCATGGCCTGTTATCTTCCTCTCTACCCCAGCTCCATGTGCAGGAAGCTCTACTCTAAGCCCATGCAGCCAAAAAGTCAGGGGCTCTGTCTTCCTGCACTTCCTAGGCTATGGCTGCAGCCCCACCCAGGAGGGGCTGGCCATGGTTCTTATTTTCCCCAGACTCATGTTGCCGAAGCCCAATTCCTGACAGGCTTGGCCTAGGGCACTAACATAAAGTAACTTAAAGTGGACTATATTCTAGACTCTACCTGGGCTCCTGAGCATTGTATCCCAGTGAG...	TCTTTCTCAGTGAGAACAGACTGAGTCTGCAGAAATTGAGCCATGGCCTGTTATCTTCCTCTCTACCCCAGCTCCATGTGCAGGAAGCTCTACTCTAAGCCCATGCAGCCAAAAAGTCAGGGGCTCTGTCTTCCTGCACTTCCTAGGCTATGGCTGCAGCCCCACCCAGGAGGGGCTGGCCATGGTTCTTATTTTCCCCAGACTCATGTTGCCGAAGCCCAATTCCTGACAGGCTTGGCCTAGGGCACTAACATAAAGTAACTTAAAGTGGACTATATTCTAGACTCTACCTGGGCTCCTGAGCATTGTATCCCAGTGAG...
Task1_train_46134	This mutation on Chromosome 18 may be significant. Is it associated with any clinical condition, or is it benign?	Benign	TCTACCCCAGCTCCATGTGCAGGAAGCTCTACTCTAAGCCCATGCAGCCAAAAAGTCAGGGGCTCTGTCTTCCTGCACTTCCTAGGCTATGGCTGCAGCCCCACCCAGGAGGGGCTGGCCATGGTTCTTATTTTCCCCAGACTCATGTTGCCGAAGCCCAATTCCTGACAGGCTTGGCCTAGGGCACTAACATAAAGTAACTTAAAGTGGACTATATTCTAGACTCTACCTGGGCTCCTGAGCATTGTATCCCAGTGAGTTCCAGCCCCAGCAGCTTGTAAGGCAGAGGTGACAGTGCTGGAGGGGCTACACCACAACCC...	TCTACCCCAGCTCCATGTGCAGGAAGCTCTACTCTAAGCCCATGCAGCCAAAAAGTCAGGGGCTCTGTCTTCCTGCACTTCCTAGGCTATGGCTGCAGCCCCACCCAGGAGGGGCTGGCCATGGTTCTTATTTTCCCCAGACTCATGTTGCCGAAGCCCAATTCCTGACAGGCTTGGCCTAGGGCACTAACATAAAGTAACTTAAAGTGGACTATATTCTAGACTCTACCTGGGCTCCTGAGCATTGTATCCCAGTGAGTTCCAGCCCCAGCAGCTTGTAAGGCAGAGGTGACAGTGCTGGAGGGGCTACACCACAACCC...
Task1_train_46135	Here is a genetic alteration on Chromosome 18. Based on the data, is it a benign variant or a cause of disease?	Benign	TGTGTCACTGGTATGAGCAGTTTAACTTTGAGAGTGTTACCTCCACACAGGTTTGCTCCTGCACCACCCCTCAGCCTTGTCCCAGAGAGCCTGTTTCTTCACCCATCACCAGCTAAAACTGTTGCACTTTTACCTCTAATGGGAAAGTAGTGTTTTTTATTTTGACACCTTCCCTGACTGAACACGGTTAGCACCGTTTCATGAGCTCATTGCAGGCATTTCCATGTCTTGCTTTAACACGCACATCAGGCCCCGTGACTCCTGCAGGGCTCCCCCAACTCTGGAAGGCGAATGCAGGGTGAGGCTTGTGAGCTTTGGGA...	TGTGTCACTGGTATGAGCAGTTTAACTTTGAGAGTGTTACCTCCACACAGGTTTGCTCCTGCACCACCCCTCAGCCTTGTCCCAGAGAGCCTGTTTCTTCACCCATCACCAGCTAAAACTGTTGCACTTTTACCTCTAATGGGAAAGTAGTGTTTTTTATTTTGACACCTTCCCTGACTGAACACGGTTAGCACCGTTTCATGAGCTCATTGCAGGCATTTCCATGTCTTGCTTTAACACGCACATCAGGCCCCGTGACTCCTGCAGGGCTCCCCCAACTCTGGAAGGCGAATGCAGGGTGAGGCTTGTGAGCTTTGGGA...
Task1_train_46136	Mutation context: Chromosome 18. Determine if this variant is likely to be benign or pathogenic. Mention the disease if applicable.	Benign	AGGTAACCAGTCGGGGAGAGGCACATTTGGAGCTGAATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCATATCTGGGGACTCTCTGGAGGTAAGGCTGGACCCTGAGTGAGTACATGTCTGTCTGTGTCTCTGAGGCAAGGCTGGTCCCTGGCTGAGTGTCTGTTTGTCTCTCAGGCAAGGCTGGACCCTGAGTGAGTACATGTCTGTCTGTCTGTCTGTCTGTGTCTCTGAGGCAAGGCTGGACCCTGGCCCAGTGTGTGTCTGTCTGTCCATTCCAGTGCATCAAGGCCTTCTTGAGTCAAGTGCTTTTGCCCAT...	AGGTAACCAGTCGGGGAGAGGCACATTTGGAGCTGAATGCATTTCGAAGGAAGCATGATTGTGCACTAGTCATATCTGGGGACTCTCTGGAGGTAAGGCTGGACCCTGAGTGAGTACATGTCTGTCTGTGTCTCTGAGGCAAGGCTGGTCCCTGGCTGAGTGTCTGTTTGTCTCTCAGGCAAGGCTGGACCCTGAGTGAGTACATGTCTGTCTGTCTGTCTGTCTGTGTCTCTGAGGCAAGGCTGGACCCTGGCCCAGTGTGTGTCTGTCTGTCCATTCCAGTGCATCAAGGCCTTCTTGAGTCAAGTGCTTTTGCCCAT...
Task1_train_46137	Consider this mutation on Chromosome 18. Is this a benign change or a disease-causing variant?	Benign	TATCATACATACAATTAGAATTGTAAAAGATATTCTAACCATTTGTGGAACTTTTGTGAAGTGAGCTCACCAAATGTCAGAGAAGATCTCACTGTGTAATTTCTGTAGAAAGGCTCCCCCGGACAGCGTCACTGCACCTGCTGCAGAAATAGCATTCCAAAGCTGGGGAACCCATGGGCTGCATGTTTCCTGTGTATTTCCAAGTTTGTCAGTAGTTGTGGATTTCAGAATTATCCCTGAAAAGTGATAACATGTGTCTGTCCCTAGGGTCCATAGACTATTTTTGCAGTGATGTCACCAAGAAAAAAATCCACCCCAGA...	TATCATACATACAATTAGAATTGTAAAAGATATTCTAACCATTTGTGGAACTTTTGTGAAGTGAGCTCACCAAATGTCAGAGAAGATCTCACTGTGTAATTTCTGTAGAAAGGCTCCCCCGGACAGCGTCACTGCACCTGCTGCAGAAATAGCATTCCAAAGCTGGGGAACCCATGGGCTGCATGTTTCCTGTGTATTTCCAAGTTTGTCAGTAGTTGTGGATTTCAGAATTATCCCTGAAAAGTGATAACATGTGTCTGTCCCTAGGGTCCATAGACTATTTTTGCAGTGATGTCACCAAGAAAAAAATCCACCCCAGA...
Task1_train_46138	A variant on Chromosome 18 has been observed. Is this a neutral mutation, or does it result in a disease? If so, which one?	Benign	AATTACTGATTTCCCTAATAATGATTTTAAAAAATATTTTATTGAGTGTAATTAACACATAATGATTCTTAGGACTAGCTGTGTACCAGAATCTTCTGTTTTGTTCTAAAAGATGGATTCGTAGGATATGAGCCAGTATCAGAATCTCCATGAGGGGGATTTCACAGTCTGTGTTTTCATCCAATCCTTGAGGAGTTTTCTTTGTAGCTGGTGATTAGGGCACCTTGACAGTGATAAGCCTGTTAAAATCTGTTTACATATGTAGGTCCTTAGATCTAAAACACATCCACCATCCATCATCATCCATCCATCATCAAACC...	AATTACTGATTTCCCTAATAATGATTTTAAAAAATATTTTATTGAGTGTAATTAACACATAATGATTCTTAGGACTAGCTGTGTACCAGAATCTTCTGTTTTGTTCTAAAAGATGGATTCGTAGGATATGAGCCAGTATCAGAATCTCCATGAGGGGGATTTCACAGTCTGTGTTTTCATCCAATCCTTGAGGAGTTTTCTTTGTAGCTGGTGATTAGGGCACCTTGACAGTGATAAGCCTGTTAAAATCTGTTTACATATGTAGGTCCTTAGATCTAAAACACATCCACCATCCATCATCATCCATCCATCATCAAACC...
Task1_train_46139	A variant was discovered on Chromosome 18. What is its functional impact — neutral or pathogenic? State the disease if pathogenic.	Benign	GGGAGCCCGTGTGATGGGGAAGCTGTGTGTGGGGTGCCCCATCCAGGTGGAGCCCCGGGGGTGGGTGCAGAGGTCCTGGGGCTGCAGGAGTGGGGAGGAGTCCCGCACGGTGAGGGAGAGCGTGTAGGAGATGGCGGCGGGGGGCCACGTTGGGGATTTTAATAAGTGATTCAAAGCCTGTAAGTCAAAAAGGGAAAGCTTTCTCTCCACGTTGACTTTTCAAGCACTGGGAGGAATGTACGCACCTGGGAATTCATTCCAAATCCCTGAGTTTGCCTCGAGAGCTGTAATCCAAGTTTCCCGCAGACAGGGCACAGTCA...	GGGAGCCCGTGTGATGGGGAAGCTGTGTGTGGGGTGCCCCATCCAGGTGGAGCCCCGGGGGTGGGTGCAGAGGTCCTGGGGCTGCAGGAGTGGGGAGGAGTCCCGCACGGTGAGGGAGAGCGTGTAGGAGATGGCGGCGGGGGGCCACGTTGGGGATTTTAATAAGTGATTCAAAGCCTGTAAGTCAAAAAGGGAAAGCTTTCTCTCCACGTTGACTTTTCAAGCACTGGGAGGAATGTACGCACCTGGGAATTCATTCCAAATCCCTGAGTTTGCCTCGAGAGCTGTAATCCAAGTTTCCCGCAGACAGGGCACAGTCA...