question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Determine if the mutation at chromosome 11, position 68780711 in gene CPT1A (carnitine palmitoyltransferase 1A) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Carnitine_palmitoyl_transferase_1A_deficiency']
ACCAGCCTGGGTGACAGAACAAGACGCCATCTCAAAAAAAAAAGTCAAAATTCAAAACATTCACAGAAGTTTAAAGAAAAAAGAAGGTCATACATTATGATGTCTTCACAAGTTTACTACTAATTTCTTTCTTTTTTTTTTGAGATGGAGTCTCACTCTTTCGTCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGCTCTGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCAGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTC...
ACCAGCCTGGGTGACAGAACAAGACGCCATCTCAAAAAAAAAAGTCAAAATTCAAAACATTCACAGAAGTTTAAAGAAAAAAGAAGGTCATACATTATGATGTCTTCACAAGTTTACTACTAATTTCTTTCTTTTTTTTTTGAGATGGAGTCTCACTCTTTCGTCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAAGCTCTGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGCCAGCCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTC...
pathogenic
179,958
Located at chromosome 11 position 68781794, the variant affecting gene CPT1A—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Carnitine_palmitoyl_transferase_1A_deficiency']
TGATTGTGCCACTGCACTCCAGTCTGGGTGACAGAGTAAGACCCTGTCTCAAAAAAAAAAAAAAAAACAATGGTAGAGGCCAATCCACAGGTGCAGGCAGGGGGACAGGGGTTTGTGGTTTTCAAATAACCTGGTAATTTTAAGAATTAAAATGATGTCTTAGGTAAAAGACACGCTGCATGTTTATAAACCCAGATTTTCACATGCTTGCTTCTATTTGGCCTAAAAAATGCGGTAGGTAGGAAACACTAGGAAATCCAGCACATAAGGGATAGTTTATTCCAGGAAAAACCGAGCTTCACTTCTGCTGTGAAGCTGCG...
TGATTGTGCCACTGCACTCCAGTCTGGGTGACAGAGTAAGACCCTGTCTCAAAAAAAAAAAAAAAAACAATGGTAGAGGCCAATCCACAGGTGCAGGCAGGGGGACAGGGGTTTGTGGTTTTCAAATAACCTGGTAATTTTAAGAATTAAAATGATGTCTTAGGTAAAAGACACGCTGCATGTTTATAAACCCAGATTTTCACATGCTTGCTTCTATTTGGCCTAAAAAATGCGGTAGGTAGGAAACACTAGGAAATCCAGCACATAAGGGATAGTTTATTCCAGGAAAAACCGAGCTTCACTTCTGCTGTGAAGCTGCG...
pathogenic
179,966
Located at chromosome 11 position 68799366, the variant affecting gene CPT1A (carnitine palmitoyltransferase 1A)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
benign
GTTTAAGAGACCAAATGGAAAGTAAATCATAAATGTCTGACTGCTAACATGTTTTAAAAACCAAAACTATGGGCTGGCCATGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGTTGAGACAGGAAGATCGCTTGATGCCAGGAGTTTGAAGCCAGCCTGGGCAACATAGCAAGGTTCCATCTCTCCAAAAAATTTTAAGAAATTAGCCAGGTGTGGTGGCTCACGCCTGTAGTCTCAGCTACTTGGGAGGCTAAGACAGGAGGGTTACTTGAGCCCAGGGGTTCCAGGCAACAGTGAGCTATGATCGTGCCACTGC...
GTTTAAGAGACCAAATGGAAAGTAAATCATAAATGTCTGACTGCTAACATGTTTTAAAAACCAAAACTATGGGCTGGCCATGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGTTGAGACAGGAAGATCGCTTGATGCCAGGAGTTTGAAGCCAGCCTGGGCAACATAGCAAGGTTCCATCTCTCCAAAAAATTTTAAGAAATTAGCCAGGTGTGGTGGCTCACGCCTGTAGTCTCAGCTACTTGGGAGGCTAAGACAGGAGGGTTACTTGAGCCCAGGGGTTCCAGGCAACAGTGAGCTATGATCGTGCCACTGC...
benign
180,005
Is chromosome 11, position 68799370, gene CPT1A (carnitine palmitoyltransferase 1A) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
AAGAGACCAAATGGAAAGTAAATCATAAATGTCTGACTGCTAACATGTTTTAAAAACCAAAACTATGGGCTGGCCATGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGTTGAGACAGGAAGATCGCTTGATGCCAGGAGTTTGAAGCCAGCCTGGGCAACATAGCAAGGTTCCATCTCTCCAAAAAATTTTAAGAAATTAGCCAGGTGTGGTGGCTCACGCCTGTAGTCTCAGCTACTTGGGAGGCTAAGACAGGAGGGTTACTTGAGCCCAGGGGTTCCAGGCAACAGTGAGCTATGATCGTGCCACTGCATTC...
AAGAGACCAAATGGAAAGTAAATCATAAATGTCTGACTGCTAACATGTTTTAAAAACCAAAACTATGGGCTGGCCATGGTGGCTCACACCTGTAATCTCAGCACTTTGGGAGGTTGAGACAGGAAGATCGCTTGATGCCAGGAGTTTGAAGCCAGCCTGGGCAACATAGCAAGGTTCCATCTCTCCAAAAAATTTTAAGAAATTAGCCAGGTGTGGTGGCTCACGCCTGTAGTCTCAGCTACTTGGGAGGCTAAGACAGGAGGGTTACTTGAGCCCAGGGGTTCCAGGCAACAGTGAGCTATGATCGTGCCACTGCATTC...
benign
180,006
The mutation impacting IGHMBP2 (immunoglobulin mu DNA binding protein 2) on chromosome 11 at position 68906222: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S']
CGTCCCCTGCTTGGCCACCTCCCGAGTTGTCAGTCTCATCACTTCCTGGGCAGCGCGTTCCGTTTGGGGACCCTTAAGAAGCACTTTGATTTCCCGACCCGAGACCCCCCACTAAGCTTACACTCCTGGGCCCTGGCCCCGACCCCAGTTCCACCCGCAGCGAGTTAGCAGCCCTTTCCCTTATTCATTCAGTAAACATGGTTTGCGCCCATTCTCAGTCAGGCCCCGGCAGCATGAGTCAGGTGCACTGGCTGCCCCCGATCCGGCCAGCGGCGGGCTGGGCATAAGCAGAGAGTCCCTTCCCCTCCAGTGCGTCCAGG...
CGTCCCCTGCTTGGCCACCTCCCGAGTTGTCAGTCTCATCACTTCCTGGGCAGCGCGTTCCGTTTGGGGACCCTTAAGAAGCACTTTGATTTCCCGACCCGAGACCCCCCACTAAGCTTACACTCCTGGGCCCTGGCCCCGACCCCAGTTCCACCCGCAGCGAGTTAGCAGCCCTTTCCCTTATTCATTCAGTAAACATGGTTTGCGCCCATTCTCAGTCAGGCCCCGGCAGCATGAGTCAGGTGCACTGGCTGCCCCCGATCCGGCCAGCGGCGGGCTGGGCATAAGCAGAGAGTCCCTTCCCCTCCAGTGCGTCCAGG...
pathogenic
180,047
Variant in IGHMBP2 (immunoglobulin mu DNA binding protein 2), chromosome 11, position 68908180—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S']
GCAGGTATCCAGCCAGCGCACTGGGCTGTACGGACGGCTGCTGGTCACCTTTGAGCCCAGGCGATACGGGTCCGCGGCAGCTCTTCCCAGTAACAGCTTTACTTCTGGTGTGTGCGTATTGACCTAGACAGACATTGAAATTTACTGGCATTCAGACCGTGACTTGTACCCTCGTAAAGACTGGATTAAAATGACCAGTTGGAGAATAAAGCGTTGCAATGAAGAACTCTTAATCAGAAGTCCAACAATTGATGTGGGTTTTAGTTGTCTAGATCAGCGTTGTCCAAAATGGTAGCCATTAGCCATGCGTGGTCATCAAA...
GCAGGTATCCAGCCAGCGCACTGGGCTGTACGGACGGCTGCTGGTCACCTTTGAGCCCAGGCGATACGGGTCCGCGGCAGCTCTTCCCAGTAACAGCTTTACTTCTGGTGTGTGCGTATTGACCTAGACAGACATTGAAATTTACTGGCATTCAGACCGTGACTTGTACCCTCGTAAAGACTGGATTAAAATGACCAGTTGGAGAATAAAGCGTTGCAATGAAGAACTCTTAATCAGAAGTCCAACAATTGATGTGGGTTTTAGTTGTCTAGATCAGCGTTGTCCAAAATGGTAGCCATTAGCCATGCGTGGTCATCAAA...
pathogenic
180,053
Is the genetic change at chromosome 11, position 68908294, within gene IGHMBP2 (immunoglobulin mu DNA binding protein 2) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S', 'IGHMBP2-related_disorder']
CGTATTGACCTAGACAGACATTGAAATTTACTGGCATTCAGACCGTGACTTGTACCCTCGTAAAGACTGGATTAAAATGACCAGTTGGAGAATAAAGCGTTGCAATGAAGAACTCTTAATCAGAAGTCCAACAATTGATGTGGGTTTTAGTTGTCTAGATCAGCGTTGTCCAAAATGGTAGCCATTAGCCATGCGTGGTCATCAAATGTTTGAAGTGTGGCTTGTAATTGCCGCAGATACAGAATACACACCAAATTTGGAAGATTATGTTAAAAAAACAATTGGGAATATCTTGAGTAATTTTTCTGAATACTGATTAC...
CGTATTGACCTAGACAGACATTGAAATTTACTGGCATTCAGACCGTGACTTGTACCCTCGTAAAGACTGGATTAAAATGACCAGTTGGAGAATAAAGCGTTGCAATGAAGAACTCTTAATCAGAAGTCCAACAATTGATGTGGGTTTTAGTTGTCTAGATCAGCGTTGTCCAAAATGGTAGCCATTAGCCATGCGTGGTCATCAAATGTTTGAAGTGTGGCTTGTAATTGCCGCAGATACAGAATACACACCAAATTTGGAAGATTATGTTAAAAAAACAATTGGGAATATCTTGAGTAATTTTTCTGAATACTGATTAC...
pathogenic
180,059
Considering the variant on chromosome 11, location 68911565, involving gene IGHMBP2 (immunoglobulin mu DNA binding protein 2), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S']
ATAAATCTTTTATTTTGAAATGTAATGATATTTCTTTTAGCTTAGTACTTTGTGAAAATAGAGGAAAGCTGATCATACTTTATGCTTGATAGCAATTTTAGGTTGGAAAAATCTTTTTTTTTTTTTTTTGAGACGGAGACTTGCTCTGTCACCAAGAGTGGGGTGCAGTGGTGCGACCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGACTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGATTACAGGTGCCCGCCACCATGCCCGGCTAATTTTTGTATTTTTTAGTAGAGACAACATGGTTTCACCATGTT...
ATAAATCTTTTATTTTGAAATGTAATGATATTTCTTTTAGCTTAGTACTTTGTGAAAATAGAGGAAAGCTGATCATACTTTATGCTTGATAGCAATTTTAGGTTGGAAAAATCTTTTTTTTTTTTTTTTGAGACGGAGACTTGCTCTGTCACCAAGAGTGGGGTGCAGTGGTGCGACCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGTGACTCTCCTGCCTCAGCCTCCCAAGTAGTTGGGATTACAGGTGCCCGCCACCATGCCCGGCTAATTTTTGTATTTTTTAGTAGAGACAACATGGTTTCACCATGTT...
pathogenic
180,071
Located at chromosome 11 position 68917800, the variant affecting gene IGHMBP2 (immunoglobulin mu DNA binding protein 2)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease', 'Charcot-Marie-Tooth_disease_axonal_type_2S', 'IGHMBP2-related_disorder', 'Neuronopathy,_distal_hereditary_motor,_autosomal_dominant']
GGATTACAGGTGTGAGCTACTGTACCCAGCCAGGGCTGCCCATTTTTGATAGAGAACTATACTTAGCATTTAACAGAGTCTCAACTGTCTTCAGAGCACTTGGTTAGTAGGTGTGAGGAATTGTAAAGAAAACATTTTCCGGCCGGATACAGTGGCTCACACGTGCAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGAACAGTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCCACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGGGCACCTGTATTCCCAGCCACTTGGGAG...
GGATTACAGGTGTGAGCTACTGTACCCAGCCAGGGCTGCCCATTTTTGATAGAGAACTATACTTAGCATTTAACAGAGTCTCAACTGTCTTCAGAGCACTTGGTTAGTAGGTGTGAGGAATTGTAAAGAAAACATTTTCCGGCCGGATACAGTGGCTCACACGTGCAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGAACAGTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCCACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGAGCATGGTGGCGGGCACCTGTATTCCCAGCCACTTGGGAG...
pathogenic
180,082
Does the chromosome 11 mutation at position 68933300 within gene IGHMBP2 (immunoglobulin mu DNA binding protein 2) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S']
GGGGTTGTCCTTCCTGGGGCGCCTGAGGGTGCAGGCTGCAGAGTGGGAGGGCAGCTACAGCTGCACCCAAGAGCTCCCGACCCACCACCTCAGAAGAGGCCAGGCTCCTGCTTGTTCCCGGCTCCTGCCTGCTTCGTGGAGCAGGAAGCCCAGGTCTGCAGCCACAGATCTGGCGGCTGCAGCTGCACGCGGAAAGGCAGATCCTACCTGTTCCCGGCTCCCCTAAGAGCACCGGGAGACGCAGATCCACAGCTGCAGTTTGGGCGGCTGTAGCCCCGCCCTTCTGGAGCAGGAGGCCTGGGTCTGTAGCTGTGACCCTG...
GGGGTTGTCCTTCCTGGGGCGCCTGAGGGTGCAGGCTGCAGAGTGGGAGGGCAGCTACAGCTGCACCCAAGAGCTCCCGACCCACCACCTCAGAAGAGGCCAGGCTCCTGCTTGTTCCCGGCTCCTGCCTGCTTCGTGGAGCAGGAAGCCCAGGTCTGCAGCCACAGATCTGGCGGCTGCAGCTGCACGCGGAAAGGCAGATCCTACCTGTTCCCGGCTCCCCTAAGAGCACCGGGAGACGCAGATCCACAGCTGCAGTTTGGGCGGCTGTAGCCCCGCCCTTCTGGAGCAGGAGGCCTGGGTCTGTAGCTGTGACCCTG...
pathogenic
180,104
Does the genetic variant at chromosome 11, position 68933375, impacting gene IGHMBP2 (immunoglobulin mu DNA binding protein 2), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S', 'Neuronopathy,_distal_hereditary_motor,_autosomal_dominant_1']
CCCGACCCACCACCTCAGAAGAGGCCAGGCTCCTGCTTGTTCCCGGCTCCTGCCTGCTTCGTGGAGCAGGAAGCCCAGGTCTGCAGCCACAGATCTGGCGGCTGCAGCTGCACGCGGAAAGGCAGATCCTACCTGTTCCCGGCTCCCCTAAGAGCACCGGGAGACGCAGATCCACAGCTGCAGTTTGGGCGGCTGTAGCCCCGCCCTTCTGGAGCAGGAGGCCTGGGTCTGTAGCTGTGACCCTGTGTCTGGGCTGCAGCGGCCACTCTACCTCAGAAGGGGCGGGGCTCCCACTGGCTTCATGGAGTGTGCAGCCACAG...
CCCGACCCACCACCTCAGAAGAGGCCAGGCTCCTGCTTGTTCCCGGCTCCTGCCTGCTTCGTGGAGCAGGAAGCCCAGGTCTGCAGCCACAGATCTGGCGGCTGCAGCTGCACGCGGAAAGGCAGATCCTACCTGTTCCCGGCTCCCCTAAGAGCACCGGGAGACGCAGATCCACAGCTGCAGTTTGGGCGGCTGTAGCCCCGCCCTTCTGGAGCAGGAGGCCTGGGTCTGTAGCTGTGACCCTGTGTCTGGGCTGCAGCGGCCACTCTACCTCAGAAGGGGCGGGGCTCCCACTGGCTTCATGGAGTGTGCAGCCACAG...
pathogenic
180,107
Is the variant located on chromosome 11 at position 68933459, gene IGHMBP2 (immunoglobulin mu DNA binding protein 2), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S']
AGCCACAGATCTGGCGGCTGCAGCTGCACGCGGAAAGGCAGATCCTACCTGTTCCCGGCTCCCCTAAGAGCACCGGGAGACGCAGATCCACAGCTGCAGTTTGGGCGGCTGTAGCCCCGCCCTTCTGGAGCAGGAGGCCTGGGTCTGTAGCTGTGACCCTGTGTCTGGGCTGCAGCGGCCACTCTACCTCAGAAGGGGCGGGGCTCCCACTGGCTTCATGGAGTGTGCAGCCACAGCCAGGGTTCCCTGCTGCAGCCGGCATGATGGCAGCAGCCACTGCCATCAGAACCTCCCTGGGAGCAGGGAGGACAGGCGTGGGA...
AGCCACAGATCTGGCGGCTGCAGCTGCACGCGGAAAGGCAGATCCTACCTGTTCCCGGCTCCCCTAAGAGCACCGGGAGACGCAGATCCACAGCTGCAGTTTGGGCGGCTGTAGCCCCGCCCTTCTGGAGCAGGAGGCCTGGGTCTGTAGCTGTGACCCTGTGTCTGGGCTGCAGCGGCCACTCTACCTCAGAAGGGGCGGGGCTCCCACTGGCTTCATGGAGTGTGCAGCCACAGCCAGGGTTCCCTGCTGCAGCCGGCATGATGGCAGCAGCCACTGCCATCAGAACCTCCCTGGGAGCAGGGAGGACAGGCGTGGGA...
pathogenic
180,109
Variant in gene IGHMBP2, located at chromosome 11 position 68934445: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
CGTAGTGGTGCAGAGGGTGGGCTCTGGCACCAGGTGGCCCGGGCAGGTCCTGGCTCTGCAGCTCACCCGGGCAGCTGTGGGCTGGCAGCCTCCTCTGTCTCACCCTTCTTACATGTAATATGGGAGTCATAACAGTAGCCACCTCATGAGGTTGTTATAAGGATGAAGGGAGTTAATCCACATCTGGCACACCCAGCAGTGCCTGGCGCCTGGGCAGTGCTCAGCCGCTGCAGCCGTTCTTGGTGGGAGTGGACTTGACTGCTCACAGTTGGAGCATGTTGGAGTGTGTTCGTTCCCTGTTATGGCTGTGACAAATGACC...
CGTAGTGGTGCAGAGGGTGGGCTCTGGCACCAGGTGGCCCGGGCAGGTCCTGGCTCTGCAGCTCACCCGGGCAGCTGTGGGCTGGCAGCCTCCTCTGTCTCACCCTTCTTACATGTAATATGGGAGTCATAACAGTAGCCACCTCATGAGGTTGTTATAAGGATGAAGGGAGTTAATCCACATCTGGCACACCCAGCAGTGCCTGGCGCCTGGGCAGTGCTCAGCCGCTGCAGCCGTTCTTGGTGGGAGTGGACTTGACTGCTCACAGTTGGAGCATGTTGGAGTGTGTTCGTTCCCTGTTATGGCTGTGACAAATGACC...
benign
180,126
A genetic alteration at chromosome 11, position 68936833, in gene IGHMBP2 (immunoglobulin mu DNA binding protein 2)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S', 'Distal_spinal_muscular_atrophy']
CACTGGCTTGTGTTCTGGCCAGATTTGCTGGGTGACCCCGGCAGCCTCAGGCTGACACAGTCCTTCCACGGGCAGCCCTGGCGGAACAGCCTGTCCTTTTCTGGCATTTCCCACAGGAGTCTCAGCCTTGAGCCTTGCTGGTCTGGCTCAGGTCGTGTTCCCATGCGTATCTCATTTGGTAGGAAAAATGTACCTTCTGGAGTATCGGGAGGATCTGTGGAAGTGGCCATCATACCTTCCTGGTGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGAC...
CACTGGCTTGTGTTCTGGCCAGATTTGCTGGGTGACCCCGGCAGCCTCAGGCTGACACAGTCCTTCCACGGGCAGCCCTGGCGGAACAGCCTGTCCTTTTCTGGCATTTCCCACAGGAGTCTCAGCCTTGAGCCTTGCTGGTCTGGCTCAGGTCGTGTTCCCATGCGTATCTCATTTGGTAGGAAAAATGTACCTTCTGGAGTATCGGGAGGATCTGTGGAAGTGGCCATCATACCTTCCTGGTGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGAC...
pathogenic
180,167
Assess the variant on chromosome 11, position 68936904, impacting IGHMBP2 (immunoglobulin mu DNA binding protein 2): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S', 'Inborn_genetic_diseases']
GCAGCCCTGGCGGAACAGCCTGTCCTTTTCTGGCATTTCCCACAGGAGTCTCAGCCTTGAGCCTTGCTGGTCTGGCTCAGGTCGTGTTCCCATGCGTATCTCATTTGGTAGGAAAAATGTACCTTCTGGAGTATCGGGAGGATCTGTGGAAGTGGCCATCATACCTTCCTGGTGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGACAGGGTGTGGTATTGGCGTGCATGCGTGCCCGTGAGGAGGGCGAACGGGAAGCCTTTCCCCATGGGGCTCCT...
GCAGCCCTGGCGGAACAGCCTGTCCTTTTCTGGCATTTCCCACAGGAGTCTCAGCCTTGAGCCTTGCTGGTCTGGCTCAGGTCGTGTTCCCATGCGTATCTCATTTGGTAGGAAAAATGTACCTTCTGGAGTATCGGGAGGATCTGTGGAAGTGGCCATCATACCTTCCTGGTGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGACAGGGTGTGGTATTGGCGTGCATGCGTGCCCGTGAGGAGGGCGAACGGGAAGCCTTTCCCCATGGGGCTCCT...
pathogenic
180,172
The chromosome 11, position 68937019 genetic variant in gene IGHMBP2 (immunoglobulin mu DNA binding protein 2): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S']
AATGTACCTTCTGGAGTATCGGGAGGATCTGTGGAAGTGGCCATCATACCTTCCTGGTGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGACAGGGTGTGGTATTGGCGTGCATGCGTGCCCGTGAGGAGGGCGAACGGGAAGCCTTTCCCCATGGGGCTCCTGCAGGCTCCGCTTCCCAGGTCCTGGCTGTTTCACAGCGTGAGGCCCTCTGCTGAGCTGAAGGGCAGGGTCTTGCTGCGCTGGCATGGGTGGGTGAGGAAACCACAGCCCGGCTGG...
AATGTACCTTCTGGAGTATCGGGAGGATCTGTGGAAGTGGCCATCATACCTTCCTGGTGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGACAGGGTGTGGTATTGGCGTGCATGCGTGCCCGTGAGGAGGGCGAACGGGAAGCCTTTCCCCATGGGGCTCCTGCAGGCTCCGCTTCCCAGGTCCTGGCTGTTTCACAGCGTGAGGCCCTCTGCTGAGCTGAAGGGCAGGGTCTTGCTGCGCTGGCATGGGTGGGTGAGGAAACCACAGCCCGGCTGG...
pathogenic
180,178
Variant in IGHMBP2 (immunoglobulin mu DNA binding protein 2), chromosome 11, position 68937074—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S', 'Neuronopathy,_distal_hereditary_motor,_autosomal_dominant']
GGTGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGACAGGGTGTGGTATTGGCGTGCATGCGTGCCCGTGAGGAGGGCGAACGGGAAGCCTTTCCCCATGGGGCTCCTGCAGGCTCCGCTTCCCAGGTCCTGGCTGTTTCACAGCGTGAGGCCCTCTGCTGAGCTGAAGGGCAGGGTCTTGCTGCGCTGGCATGGGTGGGTGAGGAAACCACAGCCCGGCTGGTGTTTCAGGTGGACCTGCTCAGACAGAGCCTTGTGCACAGGCACCCTGAGCTTGA...
GGTGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGACAGGGTGTGGTATTGGCGTGCATGCGTGCCCGTGAGGAGGGCGAACGGGAAGCCTTTCCCCATGGGGCTCCTGCAGGCTCCGCTTCCCAGGTCCTGGCTGTTTCACAGCGTGAGGCCCTCTGCTGAGCTGAAGGGCAGGGTCTTGCTGCGCTGGCATGGGTGGGTGAGGAAACCACAGCCCGGCTGGTGTTTCAGGTGGACCTGCTCAGACAGAGCCTTGTGCACAGGCACCCTGAGCTTGA...
pathogenic
180,182
Evaluate if the mutation on chromosome 11 at position 68937076 in IGHMBP2 (immunoglobulin mu DNA binding protein 2) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S']
TGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGACAGGGTGTGGTATTGGCGTGCATGCGTGCCCGTGAGGAGGGCGAACGGGAAGCCTTTCCCCATGGGGCTCCTGCAGGCTCCGCTTCCCAGGTCCTGGCTGTTTCACAGCGTGAGGCCCTCTGCTGAGCTGAAGGGCAGGGTCTTGCTGCGCTGGCATGGGTGGGTGAGGAAACCACAGCCCGGCTGGTGTTTCAGGTGGACCTGCTCAGACAGAGCCTTGTGCACAGGCACCCTGAGCTTGAAA...
TGTGCAGGCATCACACATAGGGCTGTCTGAGGCTGGCGGCTGTCATAAGCCAAAAGAAATGATCAAATGCCAGGGACAGGGTGTGGTATTGGCGTGCATGCGTGCCCGTGAGGAGGGCGAACGGGAAGCCTTTCCCCATGGGGCTCCTGCAGGCTCCGCTTCCCAGGTCCTGGCTGTTTCACAGCGTGAGGCCCTCTGCTGAGCTGAAGGGCAGGGTCTTGCTGCGCTGGCATGGGTGGGTGAGGAAACCACAGCCCGGCTGGTGTTTCAGGTGGACCTGCTCAGACAGAGCCTTGTGCACAGGCACCCTGAGCTTGAAA...
pathogenic
180,183
A mutation at chromosome position 68939544 on chromosome 11 in gene IGHMBP2 (immunoglobulin mu DNA binding protein 2): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease_axonal_type_2S']
TCCTGGGCAAAATGCTCAGAACCACAGGGGCTGGCTGAGCGCAAAACCATTCTTGCCCTTGGGCCATGTGGAGTCCCTGGGTGGGCTCTGCCCCGTTTGCCACATCCTGCATTGTGCCCACCCCGCAGGAGCTGGCTAGGCGTGCAGTGGGAGTTGGCCAGGCATACGCTGGCAGAGCGTGTAGCGGTCTTGGGGAACTCCTGCTACTGCCATTTTCCTCAGCAAGAGCATGCAGGAGTTCCAGCTTGCATTGATTCATTGAATTCCTGAAGCGAAGCTACACCAGCACATGGGTGGCTTTGAAAGGGGCCTCCCAGAGC...
TCCTGGGCAAAATGCTCAGAACCACAGGGGCTGGCTGAGCGCAAAACCATTCTTGCCCTTGGGCCATGTGGAGTCCCTGGGTGGGCTCTGCCCCGTTTGCCACATCCTGCATTGTGCCCACCCCGCAGGAGCTGGCTAGGCGTGCAGTGGGAGTTGGCCAGGCATACGCTGGCAGAGCGTGTAGCGGTCTTGGGGAACTCCTGCTACTGCCATTTTCCTCAGCAAGAGCATGCAGGAGTTCCAGCTTGCATTGATTCATTGAATTCCTGAAGCGAAGCTACACCAGCACATGGGTGGCTTTGAAAGGGGCCTCCCAGAGC...
pathogenic
180,200
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 11, position 68939657, gene IGHMBP2 (immunoglobulin mu DNA binding protein 2). What disease(s) is it linked to if pathogenic?
pathogenic; ['Autosomal_recessive_distal_spinal_muscular_atrophy_1', 'Charcot-Marie-Tooth_disease', 'Charcot-Marie-Tooth_disease_axonal_type_2S', 'Distal_spinal_muscular_atrophy', 'Inborn_genetic_diseases']
GTGCCCACCCCGCAGGAGCTGGCTAGGCGTGCAGTGGGAGTTGGCCAGGCATACGCTGGCAGAGCGTGTAGCGGTCTTGGGGAACTCCTGCTACTGCCATTTTCCTCAGCAAGAGCATGCAGGAGTTCCAGCTTGCATTGATTCATTGAATTCCTGAAGCGAAGCTACACCAGCACATGGGTGGCTTTGAAAGGGGCCTCCCAGAGCCTGGGGCTCCAGAGGAATTCACTCCCCAAACCTTTGTTGAGCAGCTACTGTATGCCACGCTTTGTGCTAGAGGACAGGACTGATGCCACCCCTGCCCCCAGGCACTGACAGGG...
GTGCCCACCCCGCAGGAGCTGGCTAGGCGTGCAGTGGGAGTTGGCCAGGCATACGCTGGCAGAGCGTGTAGCGGTCTTGGGGAACTCCTGCTACTGCCATTTTCCTCAGCAAGAGCATGCAGGAGTTCCAGCTTGCATTGATTCATTGAATTCCTGAAGCGAAGCTACACCAGCACATGGGTGGCTTTGAAAGGGGCCTCCCAGAGCCTGGGGCTCCAGAGGAATTCACTCCCCAAACCTTTGTTGAGCAGCTACTGTATGCCACGCTTTGTGCTAGAGGACAGGACTGATGCCACCCCTGCCCCCAGGCACTGACAGGG...
pathogenic
180,206
Mutation at chromosome 11, position 70473241, within SHANK2 (SH3 and multiple ankyrin repeat domains 2): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autism,_susceptibility_to,_17']
AGAAAGATTTTAAATTGCTAAATTTTATGTGTTCATTCTAGAGCTGTTCCAGACCTAATCAAGAAAAAAAGGAAAAAAAAAAAACAAAACCATGTTTTATAATTAGAGATGGGCTGAGCTAGTTCTGAAATAATAATAAAACCAAAAACCTGACATTCGAGTATCCTCCAAATGGGGGAGAATGTGCTGGAAGCCTGACTGTGTGTTTTGCGGCCCATGTGCATCTGGTGACCTCTTTTGGAAATTCGAGGTATTGTTATGGGGTGGAGGGACTCCGGGGAAAGAAAGGGGCGGGGCTCAAGAAAGCCTTGCCAGAGAGG...
AGAAAGATTTTAAATTGCTAAATTTTATGTGTTCATTCTAGAGCTGTTCCAGACCTAATCAAGAAAAAAAGGAAAAAAAAAAAACAAAACCATGTTTTATAATTAGAGATGGGCTGAGCTAGTTCTGAAATAATAATAAAACCAAAAACCTGACATTCGAGTATCCTCCAAATGGGGGAGAATGTGCTGGAAGCCTGACTGTGTGTTTTGCGGCCCATGTGCATCTGGTGACCTCTTTTGGAAATTCGAGGTATTGTTATGGGGTGGAGGGACTCCGGGGAAAGAAAGGGGCGGGGCTCAAGAAAGCCTTGCCAGAGAGG...
pathogenic
180,277
Evaluate this variant at chromosome 11, position 70486126, gene SHANK2 (SH3 and multiple ankyrin repeat domains 2): benign or pathogenic? If pathogenic, what are the disease connection(s)?
benign
GAGAGACTGAAGATGCTGCCACCTGGGGAACAGCAAAATGGTGCACACCACAGGGAAGGAGAACCAAGAACCATAAGCCATCACGGGAGCCAATGGGGCTCCCCAAAGCCACAGACTGCTGAGCCCTGATACGGTTTGGATCTGTGTTCCCACCCAAATCTCATATGTGAAATTGTAGTCTCCAGTGTTGGAGGAGGTGCCTGGTGGGAGGTGATCAGATCATGGTGGGGGAGTTCTCATGAACGGTTTAGCACCATCTTCCCTGGCTACTGTACATAGTGAGCTCTCATGAGATCAGGTTGTTTAAATAGACTGTGGTA...
GAGAGACTGAAGATGCTGCCACCTGGGGAACAGCAAAATGGTGCACACCACAGGGAAGGAGAACCAAGAACCATAAGCCATCACGGGAGCCAATGGGGCTCCCCAAAGCCACAGACTGCTGAGCCCTGATACGGTTTGGATCTGTGTTCCCACCCAAATCTCATATGTGAAATTGTAGTCTCCAGTGTTGGAGGAGGTGCCTGGTGGGAGGTGATCAGATCATGGTGGGGGAGTTCTCATGAACGGTTTAGCACCATCTTCCCTGGCTACTGTACATAGTGAGCTCTCATGAGATCAGGTTGTTTAAATAGACTGTGGTA...
benign
180,286
Assess the variant on chromosome 11, position 71094679, impacting SHANK2 (SH3 and multiple ankyrin repeat domains 2): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Autism,_susceptibility_to,_17', 'Neurodevelopmental_disorder']
ACCCCTTTTGCAGAGTGAGGTGATCCAGAAAGCAGCACCAGGACCACCCTCCCCCAGGTCAAGGCAACCCACACCCTGAGTACCCAGTGCTTCTCCTGGGCTCCCCAGAATTAAGAAGGGTATAACCTGGCCGGGTGTGGTGGCTGACGCCTATGATCCCAGCATTTTGGGAGGCTGAGGCAGGTGGATCACCCGGGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTATGAAAAATACAAAAAAAATAGCCAGCGTGGTGGCAGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGG...
ACCCCTTTTGCAGAGTGAGGTGATCCAGAAAGCAGCACCAGGACCACCCTCCCCCAGGTCAAGGCAACCCACACCCTGAGTACCCAGTGCTTCTCCTGGGCTCCCCAGAATTAAGAAGGGTATAACCTGGCCGGGTGTGGTGGCTGACGCCTATGATCCCAGCATTTTGGGAGGCTGAGGCAGGTGGATCACCCGGGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTATGAAAAATACAAAAAAAATAGCCAGCGTGGTGGCAGGTGTCTGTAATCCCAGCTACTTGGGAGGCTGAGACAGG...
pathogenic
180,300
Benign or pathogenic: chromosome 11, position 71435202, gene DHCR7 (7-dehydrocholesterol reductase) variant? Disease(s) if pathogenic?
benign
TCCTTCATTCTGGAAGGGGGCAAAGGCCAGGCCAGCTTCCCAGGGATCAGGCACTGTGGCTTCACTGGGAACAGAATGCTCTCTGTACATGGAGAATGGTAGAGGCTGGCACTGTCTAATCTGAGCTCCTGGATCACCCTGTTCTCGCCCAGAGAGAAGCTGGCTCCATCTGGGGATGAGTGAGGGCAGACGTGTCTGGTGGGACAGAGCCTGGGCCACAGCCTTGCACCTGCAGAACCCATTGTACAAACACACAGTGCATGGAAGAGGAACCTGCAGCCCAGCACAAAGCTGCTCAAACAGAAACCAAACCAAAAGCT...
TCCTTCATTCTGGAAGGGGGCAAAGGCCAGGCCAGCTTCCCAGGGATCAGGCACTGTGGCTTCACTGGGAACAGAATGCTCTCTGTACATGGAGAATGGTAGAGGCTGGCACTGTCTAATCTGAGCTCCTGGATCACCCTGTTCTCGCCCAGAGAGAAGCTGGCTCCATCTGGGGATGAGTGAGGGCAGACGTGTCTGGTGGGACAGAGCCTGGGCCACAGCCTTGCACCTGCAGAACCCATTGTACAAACACACAGTGCATGGAAGAGGAACCTGCAGCCCAGCACAAAGCTGCTCAAACAGAAACCAAACCAAAAGCT...
benign
180,311
Variant at chromosome position 71435453, chromosome 11, gene DHCR7 (7-dehydrocholesterol reductase): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Inborn_genetic_diseases', 'Smith-Lemli-Opitz_syndrome']
ACACAGTGCATGGAAGAGGAACCTGCAGCCCAGCACAAAGCTGCTCAAACAGAAACCAAACCAAAAGCTAACCTCAGCCAATTCAGAGGCAGGTCCACATCTGAACCAAGAGCTCTCCCAGCAAATTGGCCTGGAAAGCCCTTCTCACATCAAGGCAGGAAGATAATAATGACCCTCATCTTTCAAAAGAGGAAGCTGAGACACTGAGAGGGTAGGTCCCCTGAAGGTCATACAGCTCTTAAATGCTGGGGCCAGGATTCCAACGCAGGCAGGGAGGCCCGGATCTGAGCTCACAGTGACCACACCCCAGCCTCTGTGAA...
ACACAGTGCATGGAAGAGGAACCTGCAGCCCAGCACAAAGCTGCTCAAACAGAAACCAAACCAAAAGCTAACCTCAGCCAATTCAGAGGCAGGTCCACATCTGAACCAAGAGCTCTCCCAGCAAATTGGCCTGGAAAGCCCTTCTCACATCAAGGCAGGAAGATAATAATGACCCTCATCTTTCAAAAGAGGAAGCTGAGACACTGAGAGGGTAGGTCCCCTGAAGGTCATACAGCTCTTAAATGCTGGGGCCAGGATTCCAACGCAGGCAGGGAGGCCCGGATCTGAGCTCACAGTGACCACACCCCAGCCTCTGTGAA...
pathogenic
180,316
Clinical significance of chromosome 11, position 71435454, gene DHCR7 (7-dehydrocholesterol reductase): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['DHCR7-related_disorder', 'Smith-Lemli-Opitz_syndrome']
CACAGTGCATGGAAGAGGAACCTGCAGCCCAGCACAAAGCTGCTCAAACAGAAACCAAACCAAAAGCTAACCTCAGCCAATTCAGAGGCAGGTCCACATCTGAACCAAGAGCTCTCCCAGCAAATTGGCCTGGAAAGCCCTTCTCACATCAAGGCAGGAAGATAATAATGACCCTCATCTTTCAAAAGAGGAAGCTGAGACACTGAGAGGGTAGGTCCCCTGAAGGTCATACAGCTCTTAAATGCTGGGGCCAGGATTCCAACGCAGGCAGGGAGGCCCGGATCTGAGCTCACAGTGACCACACCCCAGCCTCTGTGAAC...
CACAGTGCATGGAAGAGGAACCTGCAGCCCAGCACAAAGCTGCTCAAACAGAAACCAAACCAAAAGCTAACCTCAGCCAATTCAGAGGCAGGTCCACATCTGAACCAAGAGCTCTCCCAGCAAATTGGCCTGGAAAGCCCTTCTCACATCAAGGCAGGAAGATAATAATGACCCTCATCTTTCAAAAGAGGAAGCTGAGACACTGAGAGGGTAGGTCCCCTGAAGGTCATACAGCTCTTAAATGCTGGGGCCAGGATTCCAACGCAGGCAGGGAGGCCCGGATCTGAGCTCACAGTGACCACACCCCAGCCTCTGTGAAC...
pathogenic
180,317
Gene DHCR7 (7-dehydrocholesterol reductase) variant at chromosome 11, position 71435725—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Smith-Lemli-Opitz_syndrome']
GGAGGCCCGGATCTGAGCTCACAGTGACCACACCCCAGCCTCTGTGAACTGAATTTACGCAATGTCTGGGAAGAAAAGGCAGGGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTC...
GGAGGCCCGGATCTGAGCTCACAGTGACCACACCCCAGCCTCTGTGAACTGAATTTACGCAATGTCTGGGAAGAAAAGGCAGGGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTC...
pathogenic
180,347
Variant chromosome 11, position 71435736, gene DHCR7 (7-dehydrocholesterol reductase): benign or pathogenic? Disease(s)?
pathogenic; ['DHCR7-related_disorder', 'Smith-Lemli-Opitz_syndrome']
TCTGAGCTCACAGTGACCACACCCCAGCCTCTGTGAACTGAATTTACGCAATGTCTGGGAAGAAAAGGCAGGGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTCATGTGAAGCAA...
TCTGAGCTCACAGTGACCACACCCCAGCCTCTGTGAACTGAATTTACGCAATGTCTGGGAAGAAAAGGCAGGGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTCATGTGAAGCAA...
pathogenic
180,348
Is the genetic change at chromosome 11, position 71435745, within gene DHCR7 (7-dehydrocholesterol reductase) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Smith-Lemli-Opitz_syndrome']
ACAGTGACCACACCCCAGCCTCTGTGAACTGAATTTACGCAATGTCTGGGAAGAAAAGGCAGGGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTCATGTGAAGCAATGAAGCCAC...
ACAGTGACCACACCCCAGCCTCTGTGAACTGAATTTACGCAATGTCTGGGAAGAAAAGGCAGGGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTCATGTGAAGCAATGAAGCCAC...
pathogenic
180,349
Clinical significance of chromosome 11, position 71435798, gene DHCR7 (7-dehydrocholesterol reductase): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Smith-Lemli-Opitz_syndrome']
AAAAGGCAGGGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTCATGTGAAGCAATGAAGCCACTCTGAGCTTGGCCCCCTGCCCTGGCATGGGCACTGGGCTGCCTGTGTGAAACT...
AAAAGGCAGGGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTCATGTGAAGCAATGAAGCCACTCTGAGCTTGGCCCCCTGCCCTGGCATGGGCACTGGGCTGCCTGTGTGAAACT...
pathogenic
180,353
A mutation at chromosome position 71435807 on chromosome 11 in gene DHCR7 (7-dehydrocholesterol reductase): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Smith-Lemli-Opitz_syndrome']
GGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTCATGTGAAGCAATGAAGCCACTCTGAGCTTGGCCCCCTGCCCTGGCATGGGCACTGGGCTGCCTGTGTGAAACTCTTGTTTCT...
GGTCCACTCCGCTCAGAGCCATGCAGGGCAGTGTGCTCCCGTCTCCCCGGCATTTGAATCACTCTTGTGGTGTGTGTCCAGCACAGATGCACGGGACCCCTCAGGCCCATATCCTCAAACAGGTAGTGGTGGGGCACCAGTGCACGAACACTAGGGCTCAGCAGTCAGCCTGGGCGGGTCACAGTTCCGATACCCTCCAGGCTGTCTGGGAGGCGGCCTGGCTGTGGGACCAGTTCTCATGTGAAGCAATGAAGCCACTCTGAGCTTGGCCCCCTGCCCTGGCATGGGCACTGGGCTGCCTGTGTGAAACTCTTGTTTCT...
pathogenic
180,354
Determine whether the variant at chromosome 11, position 71437822, in gene DHCR7 (7-dehydrocholesterol reductase) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Smith-Lemli-Opitz_syndrome']
CAGCAGCAGGACGCCCACGGCGTGCGGGGTGGACAGCTGCACGGGGTGGTACACCAAGTACAGACCCTGGGGGGCGAGGGGGAAGGGGTCAAGCGGTGCTTTGCCCAGGGAGAGGACAGGAGTGTGGGCTCGGGGGCCCAGCGGCCTGGGGTCAAACCCCAGCTCTGCCTCTGACACACGCCTTGCCTCCGTGTTCTCTTCTGTGAATAAAAGCACCAACCTTGAGGGCTGTTGTGGTCATTAAATGAGTAACTCTACCTGCCTTCTACCTGTCTGTGTGTGTATGTGTGTGTGTATATATACCCCCTATATATATGACA...
CAGCAGCAGGACGCCCACGGCGTGCGGGGTGGACAGCTGCACGGGGTGGTACACCAAGTACAGACCCTGGGGGGCGAGGGGGAAGGGGTCAAGCGGTGCTTTGCCCAGGGAGAGGACAGGAGTGTGGGCTCGGGGGCCCAGCGGCCTGGGGTCAAACCCCAGCTCTGCCTCTGACACACGCCTTGCCTCCGTGTTCTCTTCTGTGAATAAAAGCACCAACCTTGAGGGCTGTTGTGGTCATTAAATGAGTAACTCTACCTGCCTTCTACCTGTCTGTGTGTGTATGTGTGTGTGTATATATACCCCCTATATATATGACA...
pathogenic
180,366
Is the genetic variant on chromosome 11, position 71437900, gene DHCR7 (7-dehydrocholesterol reductase), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Smith-Lemli-Opitz_syndrome']
GGGGAAGGGGTCAAGCGGTGCTTTGCCCAGGGAGAGGACAGGAGTGTGGGCTCGGGGGCCCAGCGGCCTGGGGTCAAACCCCAGCTCTGCCTCTGACACACGCCTTGCCTCCGTGTTCTCTTCTGTGAATAAAAGCACCAACCTTGAGGGCTGTTGTGGTCATTAAATGAGTAACTCTACCTGCCTTCTACCTGTCTGTGTGTGTATGTGTGTGTGTATATATACCCCCTATATATATGACATATAGCATAAACATCAAATATGTAACAGTATTAAAAATATAATCTGAATTTAATATTGTGATGGTCAATTTAACGTGT...
GGGGAAGGGGTCAAGCGGTGCTTTGCCCAGGGAGAGGACAGGAGTGTGGGCTCGGGGGCCCAGCGGCCTGGGGTCAAACCCCAGCTCTGCCTCTGACACACGCCTTGCCTCCGTGTTCTCTTCTGTGAATAAAAGCACCAACCTTGAGGGCTGTTGTGGTCATTAAATGAGTAACTCTACCTGCCTTCTACCTGTCTGTGTGTGTATGTGTGTGTGTATATATACCCCCTATATATATGACATATAGCATAAACATCAAATATGTAACAGTATTAAAAATATAATCTGAATTTAATATTGTGATGGTCAATTTAACGTGT...
pathogenic
180,374
Benign or pathogenic: chromosome 11, position 71438906, gene DHCR7 (7-dehydrocholesterol reductase) variant? Disease(s) if pathogenic?
pathogenic; ['Smith-Lemli-Opitz_syndrome']
ATGTACATCTCGAGACACACACAGAGGCTAAAGCAAGTAAGAGCTATTATATAGTGGGACCTATTGCTACGTTTTCACATCCTTGGAAAATGGAGTTTATAAAACCAGGGAACCAGCAGACCTGCAGCCAGCCAGGTGGAGAAATGGGGCCGGGTGGGCCATGCGGGGGGCTCCAAGGACCTGGTGTGAGCATGGGGCCAGCTGGGGCTCTGCACCCTCCACCTGGTACTGGCCCCCTCTGCTGTGGGAATCCTGGTTTTCCAGGACACCCGCACCTCCATCCCACAGGACTGGCTGTCACAGGTGATGCCGGGCCTGTC...
ATGTACATCTCGAGACACACACAGAGGCTAAAGCAAGTAAGAGCTATTATATAGTGGGACCTATTGCTACGTTTTCACATCCTTGGAAAATGGAGTTTATAAAACCAGGGAACCAGCAGACCTGCAGCCAGCCAGGTGGAGAAATGGGGCCGGGTGGGCCATGCGGGGGGCTCCAAGGACCTGGTGTGAGCATGGGGCCAGCTGGGGCTCTGCACCCTCCACCTGGTACTGGCCCCCTCTGCTGTGGGAATCCTGGTTTTCCAGGACACCCGCACCTCCATCCCACAGGACTGGCTGTCACAGGTGATGCCGGGCCTGTC...
pathogenic
180,388
Variant in gene DHCR7 (7-dehydrocholesterol reductase), located at chromosome 11 position 71442257: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['DHCR7-related_disorder', 'Smith-Lemli-Opitz_syndrome']
GAGGCCGGTCAGGAGCTGCGGACATTGCTCAGGCAGGAGGTTGACCTGGATGAGATGATGCATTCCTTCCCCTCGGCACATGCCATTACAGGCCCTGATAGAGTGGATGGATGGGTAAATGGATGGATGACGGGCAGGTGGATGGGTGGGTGGCTAGATGTGTAGGTGGGTGGGTAGGTGGATAGGTGGATGGACAAATAGATGACGGGTGGGTAGACAGACGGGGTGGAGGGTGGATGGGCAGGTGGATGAGATGGATGATGGATGGGTGGGTGGGTAGGTGGAAGGATGGGGAGATGGGCAGGTGGATGGGTGTGTGG...
GAGGCCGGTCAGGAGCTGCGGACATTGCTCAGGCAGGAGGTTGACCTGGATGAGATGATGCATTCCTTCCCCTCGGCACATGCCATTACAGGCCCTGATAGAGTGGATGGATGGGTAAATGGATGGATGACGGGCAGGTGGATGGGTGGGTGGCTAGATGTGTAGGTGGGTGGGTAGGTGGATAGGTGGATGGACAAATAGATGACGGGTGGGTAGACAGACGGGGTGGAGGGTGGATGGGCAGGTGGATGAGATGGATGATGGATGGGTGGGTGGGTAGGTGGAAGGATGGGGAGATGGGCAGGTGGATGGGTGTGTGG...
pathogenic
180,433
Variant chromosome 11, position 71442319, gene DHCR7 (7-dehydrocholesterol reductase): benign or pathogenic? Disease(s)?
pathogenic; ['Smith-Lemli-Opitz_syndrome']
TTCCTTCCCCTCGGCACATGCCATTACAGGCCCTGATAGAGTGGATGGATGGGTAAATGGATGGATGACGGGCAGGTGGATGGGTGGGTGGCTAGATGTGTAGGTGGGTGGGTAGGTGGATAGGTGGATGGACAAATAGATGACGGGTGGGTAGACAGACGGGGTGGAGGGTGGATGGGCAGGTGGATGAGATGGATGATGGATGGGTGGGTGGGTAGGTGGAAGGATGGGGAGATGGGCAGGTGGATGGGTGTGTGGCTAGATGTGTAGGTGGGTGGGTAGGTGGATGGGCAGATGGATGAATGGGTGATGGGAGGGTA...
TTCCTTCCCCTCGGCACATGCCATTACAGGCCCTGATAGAGTGGATGGATGGGTAAATGGATGGATGACGGGCAGGTGGATGGGTGGGTGGCTAGATGTGTAGGTGGGTGGGTAGGTGGATAGGTGGATGGACAAATAGATGACGGGTGGGTAGACAGACGGGGTGGAGGGTGGATGGGCAGGTGGATGAGATGGATGATGGATGGGTGGGTGGGTAGGTGGAAGGATGGGGAGATGGGCAGGTGGATGGGTGTGTGGCTAGATGTGTAGGTGGGTGGGTAGGTGGATGGGCAGATGGATGAATGGGTGATGGGAGGGTA...
pathogenic
180,437
Gene DHCR7 (7-dehydrocholesterol reductase) variant at chromosome position 71444848 on chromosome 11: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Smith-Lemli-Opitz_syndrome']
GTGTGCACCACCACACCCGGCTAAAATTCACCCTTTTAAAGTGCACAATTCAGCGGCATTTAGCGCATTTACATGGTTGGTTGTACACCTATCACTGCTAATTCCAGAACTTTTCATCACCACAGAAGAAAATGTTGTTCCAATCTCCGGTCACTCTGAATTCCCTGTCCCTGCCGCCCCTGGCTGCCACTGAGCTTTCTGCCTCTGTGGATTTGCCTGTACTGGGTATTGCATATAAAGGGAACCACACAGTATGCAGCCTCTGTGACTGGCTTCTCTCGCTCAGCAGTGTCTTCAAGGGTCATCCGCCTACTGGCATC...
GTGTGCACCACCACACCCGGCTAAAATTCACCCTTTTAAAGTGCACAATTCAGCGGCATTTAGCGCATTTACATGGTTGGTTGTACACCTATCACTGCTAATTCCAGAACTTTTCATCACCACAGAAGAAAATGTTGTTCCAATCTCCGGTCACTCTGAATTCCCTGTCCCTGCCGCCCCTGGCTGCCACTGAGCTTTCTGCCTCTGTGGATTTGCCTGTACTGGGTATTGCATATAAAGGGAACCACACAGTATGCAGCCTCTGTGACTGGCTTCTCTCGCTCAGCAGTGTCTTCAAGGGTCATCCGCCTACTGGCATC...
pathogenic
180,466
Variant chromosome 11, position 72108662, gene ANAPC15: benign or pathogenic? Disease(s)?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_63', 'Inborn_genetic_diseases']
ATCTCAATCCCAGCATAAGTGCTTTTAGGGTCTTATTTAAGAAATTCGGCTGTGTGGTGGCTGGTGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCGGCTTGGGCAACATGGCAAAAACCCATCTCTACAAAAAATACAAAAATTACCCAGGCATGGTGGCACATGCCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGGCTGAGGCTGCAGTGAGCTGTGATTGTGCCACTGCACTCCAGCATGGGTGACAGAGCAAGAAC...
ATCTCAATCCCAGCATAAGTGCTTTTAGGGTCTTATTTAAGAAATTCGGCTGTGTGGTGGCTGGTGCCTGTAATCCCAGCACTTTGAGAGGCCGAGGTGGGCAGATTGCTTGAGCTCAGGAGTTTGAGACCGGCTTGGGCAACATGGCAAAAACCCATCTCTACAAAAAATACAAAAATTACCCAGGCATGGTGGCACATGCCTGTGGTCCCAGCTACTTGGGAGGCTGAGGTGGGAGGATTGCTTGAGCCCAGGAGGCTGAGGCTGCAGTGAGCTGTGATTGTGCCACTGCACTCCAGCATGGGTGACAGAGCAAGAAC...
pathogenic
180,527
For chromosome 11, position 72225181, gene INPPL1: benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
benign
GACCCGGGCTCCGTCAACAGGTTCAACGTAGCAAAGTGAAAGTTCTCTCCCAGGTTAAAGGGATTCTCCCACGGCGGCCCAGGAGATGGTGGCGGCGGGCGCCCGGCTGGAGGCCTGCGCCTTTAAGGAGCCAGGGGGCGGAGGGGCGGGGCAGGAAGACGACTCCCCGGAGACGCCGCCACCGGCTAGGTCTTTTTTTGGGAGGGGGCGGGCCAGACCCTTTTATGGGCTCCGCCCCCTTTGCGGCTGCCGCGTCCCCCTTCCGCCCTCGGCTGGAGGGGAGGAAGCTAGGGGGGCGTTGCAGCGGACCCCGTCTGGGA...
GACCCGGGCTCCGTCAACAGGTTCAACGTAGCAAAGTGAAAGTTCTCTCCCAGGTTAAAGGGATTCTCCCACGGCGGCCCAGGAGATGGTGGCGGCGGGCGCCCGGCTGGAGGCCTGCGCCTTTAAGGAGCCAGGGGGCGGAGGGGCGGGGCAGGAAGACGACTCCCCGGAGACGCCGCCACCGGCTAGGTCTTTTTTTGGGAGGGGGCGGGCCAGACCCTTTTATGGGCTCCGCCCCCTTTGCGGCTGCCGCGTCCCCCTTCCGCCCTCGGCTGGAGGGGAGGAAGCTAGGGGGGCGTTGCAGCGGACCCCGTCTGGGA...
benign
180,569
Gene CLPB (ClpB family mitochondrial disaggregase) variant at chromosome position 72294455 on chromosome 11: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
GGTGTCCAGACCCTCTGCTTTGTGACTAACATGCAGACTGAATAAACTGCATGTTTATTCCAGGCTCGTTTAGCTGGACGAGCAGTACAGACAGGGCTGAGGCTGACTCCATGGCCATGTGGGCAGAGGTCAAACCCATGATCTCTCTTCCTACAGCTTCCTAATGTCTGCGATGTTGGTCTTTTGAAGGAGGCCCCCACAGAGCTGAGCTTGCTTGGTTATCTGGGACTGCTGCTCAGTCTGAGTAGGGGAGGGTAATGAACCAGTCAGGCCTCCTCCTGGAGGTGCCCAACACTGGCCTAGTCCCCAAGGCTGACGAA...
GGTGTCCAGACCCTCTGCTTTGTGACTAACATGCAGACTGAATAAACTGCATGTTTATTCCAGGCTCGTTTAGCTGGACGAGCAGTACAGACAGGGCTGAGGCTGACTCCATGGCCATGTGGGCAGAGGTCAAACCCATGATCTCTCTTCCTACAGCTTCCTAATGTCTGCGATGTTGGTCTTTTGAAGGAGGCCCCCACAGAGCTGAGCTTGCTTGGTTATCTGGGACTGCTGCTCAGTCTGAGTAGGGGAGGGTAATGAACCAGTCAGGCCTCCTCCTGGAGGTGCCCAACACTGGCCTAGTCCCCAAGGCTGACGAA...
benign
180,622
Is the genetic variant on chromosome 11, position 72295503, gene CLPB (ClpB family mitochondrial disaggregase), benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
CGCAGCTTGGGGAGGCGCTTCTCAGCCTGGGGTGAGGGCAGTTCTGGGCTTTTGAGTAGCTGCTTGTCTGAGTCCTCCACCGTGATGCGCAAAGTACAGCCCCCTGGCAGCAGGTCCTGCTCATAGGCTGCTGCCAGCTGGTTCACCACACGGCGTTCTACCTGTCGGTGGGGAGGTGAAGTGGTCACTCCCTCGGCCTGGACCCAGCTTGGAGGTCGGCCTCCATCACTTACTGCTAGGGCAACTCAGAGACCTCCTTTGAGCCTGAGCCTCAGCTTTCTCATTTGCCAATTGGGGCTAATAACAGCTAGCTCGCAGGA...
CGCAGCTTGGGGAGGCGCTTCTCAGCCTGGGGTGAGGGCAGTTCTGGGCTTTTGAGTAGCTGCTTGTCTGAGTCCTCCACCGTGATGCGCAAAGTACAGCCCCCTGGCAGCAGGTCCTGCTCATAGGCTGCTGCCAGCTGGTTCACCACACGGCGTTCTACCTGTCGGTGGGGAGGTGAAGTGGTCACTCCCTCGGCCTGGACCCAGCTTGGAGGTCGGCCTCCATCACTTACTGCTAGGGCAACTCAGAGACCTCCTTTGAGCCTGAGCCTCAGCTTTCTCATTTGCCAATTGGGGCTAATAACAGCTAGCTCGCAGGA...
benign
180,626
Variant at chromosome position 72373006, chromosome 11, gene CLPB (ClpB family mitochondrial disaggregase): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['3-methylglutaconic_aciduria,_type_VIIB']
TTATTGCTCATTACTCTCTAAGATGAATCTTCTGCTGTGTGCCTGCTTCACCCTAACATGTTCGTCTATCAGCGTGAAACATAATTTTTCTGTTTCTCATATCTGAGTGGTTTTTTTGTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCATGGCTTACTGCAGCCTTGACCTCCTGGGCTCAGGCAATCCTCCTGTCTCAGCCTCCTGAGTAGCTGGGACCACAGGCACAACCCACTACACCTGGCTAATTAAAAAATATATATATTGGGCAGGGCGTGGTGGCTCATTACTAATC...
TTATTGCTCATTACTCTCTAAGATGAATCTTCTGCTGTGTGCCTGCTTCACCCTAACATGTTCGTCTATCAGCGTGAAACATAATTTTTCTGTTTCTCATATCTGAGTGGTTTTTTTGTTTTTTGAGACAGGGTCTTGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCATGGCTTACTGCAGCCTTGACCTCCTGGGCTCAGGCAATCCTCCTGTCTCAGCCTCCTGAGTAGCTGGGACCACAGGCACAACCCACTACACCTGGCTAATTAAAAAATATATATATTGGGCAGGGCGTGGTGGCTCATTACTAATC...
pathogenic
180,661
Evaluate the clinical significance of the mutation at chromosome 11, position 74042223 in gene C2CD3 (C2 domain containing 3 centriole elongation regulator): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
benign
TTGTGAACTGCTCATGTGAGGGATCTAGGTTGTGCGCTCCTTATGAGAATCTAAATAATGCCTGATGATGGGAGGTGGAACAGTTTCATCTGGAAACCACCCCCCACCCCCAACCCCACCCTTGTGGAAGAAAAATGGTCTTCCACAAAACCAGTGTCTGGTGCCAAAAAGGTTGGGGCTGCTGGTCTATAGCACTATTGATCAATTTTTAACTTGTCTCATTAACCAAAAAGATTTTGTTGATGTTTCTTTTCTGACTTTGCATTATGAATCAAAGAATAGGTTAGTTTTTTTTTTTTCAAATATAAAGTCTTTTGGCC...
TTGTGAACTGCTCATGTGAGGGATCTAGGTTGTGCGCTCCTTATGAGAATCTAAATAATGCCTGATGATGGGAGGTGGAACAGTTTCATCTGGAAACCACCCCCCACCCCCAACCCCACCCTTGTGGAAGAAAAATGGTCTTCCACAAAACCAGTGTCTGGTGCCAAAAAGGTTGGGGCTGCTGGTCTATAGCACTATTGATCAATTTTTAACTTGTCTCATTAACCAAAAAGATTTTGTTGATGTTTCTTTTCTGACTTTGCATTATGAATCAAAGAATAGGTTAGTTTTTTTTTTTTCAAATATAAAGTCTTTTGGCC...
benign
180,791
Clinical significance of chromosome 11, position 74098016, gene C2CD3 (C2 domain containing 3 centriole elongation regulator): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Orofaciodigital_syndrome_type_14']
GTACTAATTACTATTTCAAATCAGTTGGGTATAACACCAGGACTGTCCAATAATGGTAAGGACTACTTTGGGAGGTAGTGAAGACACTGTTACTAAAGGTAATAACAACAAATAATCGTGTATTTATTGAGGATTTACTATGAACCAGGCACTATACCAAACAGCTCACCTTCATTAAGTGATTTAACATGCAGAGCTAGTAACAGTGGAACCAGGTTTAGACTCAACGTAGTCTGACTCCAGAGTCAGTGTTCTTTATCCCTATTCTATACAGCAGATCTTAGAGAATGAATTATTCAGGAAAATTCAAAGGGGGAATT...
GTACTAATTACTATTTCAAATCAGTTGGGTATAACACCAGGACTGTCCAATAATGGTAAGGACTACTTTGGGAGGTAGTGAAGACACTGTTACTAAAGGTAATAACAACAAATAATCGTGTATTTATTGAGGATTTACTATGAACCAGGCACTATACCAAACAGCTCACCTTCATTAAGTGATTTAACATGCAGAGCTAGTAACAGTGGAACCAGGTTTAGACTCAACGTAGTCTGACTCCAGAGTCAGTGTTCTTTATCCCTATTCTATACAGCAGATCTTAGAGAATGAATTATTCAGGAAAATTCAAAGGGGGAATT...
pathogenic
180,834
Clinically, how would you classify the variant at chromosome 11, position 74098243, gene C2CD3 (C2 domain containing 3 centriole elongation regulator): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Orofaciodigital_syndrome_type_14']
CGTAGTCTGACTCCAGAGTCAGTGTTCTTTATCCCTATTCTATACAGCAGATCTTAGAGAATGAATTATTCAGGAAAATTCAAAGGGGGAATTCAGCATTCAGAAAAGAGTTGAGACTATATGATATACATGTGTTTAACATTTTAACTACTAATCCAAAAAATCTAGAACAGAGACTGTATTAGGTCTCTGCTTTGAAATCTGAAAGCATATTTTAGCAATACCTGCTCAAAAATTTTCCTTAGAAAAACAGGAAACTTGCAATTTGATTCCCTCGGGCAAAAAAAATTGAAAAAAAAAATCTCTCAGAGTCACAACAG...
CGTAGTCTGACTCCAGAGTCAGTGTTCTTTATCCCTATTCTATACAGCAGATCTTAGAGAATGAATTATTCAGGAAAATTCAAAGGGGGAATTCAGCATTCAGAAAAGAGTTGAGACTATATGATATACATGTGTTTAACATTTTAACTACTAATCCAAAAAATCTAGAACAGAGACTGTATTAGGTCTCTGCTTTGAAATCTGAAAGCATATTTTAGCAATACCTGCTCAAAAATTTTCCTTAGAAAAACAGGAAACTTGCAATTTGATTCCCTCGGGCAAAAAAAATTGAAAAAAAAAATCTCTCAGAGTCACAACAG...
pathogenic
180,837
Variant in gene C2CD3 (C2 domain containing 3 centriole elongation regulator), located at chromosome 11 position 74133518: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Orofaciodigital_syndrome_type_14']
TTTTTATATGTTGCTGGGTTCGGTTTGCAAGTATTTTCTGGAGTATGTTGTGTTGTTACTTCCCTGTAATAGAAATCTAAACTTCAGATCAAACTAATTGGAGGTTTTGTTTTTCTTTCTTTTTTTTTTTGAGATGGAGTCTTACTCCTTCTATCATCCAGGCCAGAGTGCAGTAGCATGTTCTCGGCTCATTGCAACCTCTGCCTCCAGGTTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGCACCACCACGCCTGGCTCATTTTTGTACTGTTAGTAGAGACAGGGTTTCACCCTGTTGGCCAGGCTGGTC...
TTTTTATATGTTGCTGGGTTCGGTTTGCAAGTATTTTCTGGAGTATGTTGTGTTGTTACTTCCCTGTAATAGAAATCTAAACTTCAGATCAAACTAATTGGAGGTTTTGTTTTTCTTTCTTTTTTTTTTTGAGATGGAGTCTTACTCCTTCTATCATCCAGGCCAGAGTGCAGTAGCATGTTCTCGGCTCATTGCAACCTCTGCCTCCAGGTTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGCACCACCACGCCTGGCTCATTTTTGTACTGTTAGTAGAGACAGGGTTTCACCCTGTTGGCCAGGCTGGTC...
pathogenic
180,859
Does the chromosome 11 mutation at position 75566995 within gene SERPINH1 (serpin family H member 1) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
GGTCTTCTTCAAGGATGACTACAAGTTGGGATCTACCAGAGCAGTGGGATCGCAGCCTCCACCAGGATTCCTTCTATCCTTCCCTTTGCCCTGTCATCTCTCCTGTGCTGTTGCATGATGTAGAGGAGGATAATGGCCCGAAGGGAGAGAGGGAGTGTGGAAGTATCCCAGGAACAGAGACTGTCCAAATTGGAGGCCCCAGAGAGGGAACTGGGGCTTGTCCTTGGGGCCACTGCTACTGCTGGGGCTTGGGGAGGAGGCCTGAGGGCAACCCTGAAGCCGTGGAGCAGATGGCCTGTGTGGCAGTGGCTGTCAGATTG...
GGTCTTCTTCAAGGATGACTACAAGTTGGGATCTACCAGAGCAGTGGGATCGCAGCCTCCACCAGGATTCCTTCTATCCTTCCCTTTGCCCTGTCATCTCTCCTGTGCTGTTGCATGATGTAGAGGAGGATAATGGCCCGAAGGGAGAGAGGGAGTGTGGAAGTATCCCAGGAACAGAGACTGTCCAAATTGGAGGCCCCAGAGAGGGAACTGGGGCTTGTCCTTGGGGCCACTGCTACTGCTGGGGCTTGGGGAGGAGGCCTGAGGGCAACCCTGAAGCCGTGGAGCAGATGGCCTGTGTGGCAGTGGCTGTCAGATTG...
benign
180,936
Determine whether the variant at chromosome 11, position 77142737, in gene MYO7A (myosin VIIA) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
benign
AGTGCAGCTGGGGCTTGGACACAAGCAGCTGTGAGGATTATATGGGGCAGTTTACGGGATGCAGCCTGTGGAGCCCAGGCCCACAGTGAATGCTCAGTAAACAGTTCTCTTCCACGCCCAAGCCTCTCCAATTTTTCTTACTTTTTCTGGGAGGAAGTTTGGGTTTGGGACTAGCCTGACTCTATCATGTGCCAACCTCCCATTCACATGAAGAGAGGGTCCACAGGGGCAGCTGTGGCTGGAAAATAGCACATAGATGGCAGTGGTCCCATAAGACTATAATGCCATATTTTACTGTACCTTTTATGTGTATGTTTAGA...
AGTGCAGCTGGGGCTTGGACACAAGCAGCTGTGAGGATTATATGGGGCAGTTTACGGGATGCAGCCTGTGGAGCCCAGGCCCACAGTGAATGCTCAGTAAACAGTTCTCTTCCACGCCCAAGCCTCTCCAATTTTTCTTACTTTTTCTGGGAGGAAGTTTGGGTTTGGGACTAGCCTGACTCTATCATGTGCCAACCTCCCATTCACATGAAGAGAGGGTCCACAGGGGCAGCTGTGGCTGGAAAATAGCACATAGATGGCAGTGGTCCCATAAGACTATAATGCCATATTTTACTGTACCTTTTATGTGTATGTTTAGA...
benign
180,997
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 11, position 77142788, gene MYO7A (myosin VIIA). What disease(s) is it linked to if pathogenic?
pathogenic; ['MYO7A-related_disorder']
TTACGGGATGCAGCCTGTGGAGCCCAGGCCCACAGTGAATGCTCAGTAAACAGTTCTCTTCCACGCCCAAGCCTCTCCAATTTTTCTTACTTTTTCTGGGAGGAAGTTTGGGTTTGGGACTAGCCTGACTCTATCATGTGCCAACCTCCCATTCACATGAAGAGAGGGTCCACAGGGGCAGCTGTGGCTGGAAAATAGCACATAGATGGCAGTGGTCCCATAAGACTATAATGCCATATTTTACTGTACCTTTTATGTGTATGTTTAGATATGTTTACATACACAAATACACACTATGGATTATGACTGCCTATAGTATT...
TTACGGGATGCAGCCTGTGGAGCCCAGGCCCACAGTGAATGCTCAGTAAACAGTTCTCTTCCACGCCCAAGCCTCTCCAATTTTTCTTACTTTTTCTGGGAGGAAGTTTGGGTTTGGGACTAGCCTGACTCTATCATGTGCCAACCTCCCATTCACATGAAGAGAGGGTCCACAGGGGCAGCTGTGGCTGGAAAATAGCACATAGATGGCAGTGGTCCCATAAGACTATAATGCCATATTTTACTGTACCTTTTATGTGTATGTTTAGATATGTTTACATACACAAATACACACTATGGATTATGACTGCCTATAGTATT...
pathogenic
181,004
Is chromosome 11, position 77147799, gene MYO7A (myosin VIIA) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Usher_syndrome_type_2']
GGCCCAGAAGTGCCGTGGAGTATCAGGGAAACTGGGGTGGGGGGCTCTGTCCAGCGCAGCCCCTAATCCCCCTGAGGGCCTGGGCAGGCTGCCACCCTCCTCCGAGCCTGTTTTCTCATGTGAAGTGAGGGGGCTGGAATGGGGGACTTCTGGGGTCTGTCCATGACTGACTTCTGCCTCTCATTCAGACCTGGTCCCCCGCAGTCACCAGCCAGCCATCTGTCCCATCAGAGGCTCCCTGCCACATCATTTGTGCCCGGCCCCTGTGTGAGGCACCGTGGCCTGAGATGTGGCCCTGGAGGCAGGGGGATGGCACAGAT...
GGCCCAGAAGTGCCGTGGAGTATCAGGGAAACTGGGGTGGGGGGCTCTGTCCAGCGCAGCCCCTAATCCCCCTGAGGGCCTGGGCAGGCTGCCACCCTCCTCCGAGCCTGTTTTCTCATGTGAAGTGAGGGGGCTGGAATGGGGGACTTCTGGGGTCTGTCCATGACTGACTTCTGCCTCTCATTCAGACCTGGTCCCCCGCAGTCACCAGCCAGCCATCTGTCCCATCAGAGGCTCCCTGCCACATCATTTGTGCCCGGCCCCTGTGTGAGGCACCGTGGCCTGAGATGTGGCCCTGGAGGCAGGGGGATGGCACAGAT...
pathogenic
181,010
Regarding the variant at chromosome 11 and position 77147844, affecting gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2']
TCTGTCCAGCGCAGCCCCTAATCCCCCTGAGGGCCTGGGCAGGCTGCCACCCTCCTCCGAGCCTGTTTTCTCATGTGAAGTGAGGGGGCTGGAATGGGGGACTTCTGGGGTCTGTCCATGACTGACTTCTGCCTCTCATTCAGACCTGGTCCCCCGCAGTCACCAGCCAGCCATCTGTCCCATCAGAGGCTCCCTGCCACATCATTTGTGCCCGGCCCCTGTGTGAGGCACCGTGGCCTGAGATGTGGCCCTGGAGGCAGGGGGATGGCACAGATGGAGCATGTGAGGGTGGCCAGCACTGTCAGGGGAGGCTTCAGAAA...
TCTGTCCAGCGCAGCCCCTAATCCCCCTGAGGGCCTGGGCAGGCTGCCACCCTCCTCCGAGCCTGTTTTCTCATGTGAAGTGAGGGGGCTGGAATGGGGGACTTCTGGGGTCTGTCCATGACTGACTTCTGCCTCTCATTCAGACCTGGTCCCCCGCAGTCACCAGCCAGCCATCTGTCCCATCAGAGGCTCCCTGCCACATCATTTGTGCCCGGCCCCTGTGTGAGGCACCGTGGCCTGAGATGTGGCCCTGGAGGCAGGGGGATGGCACAGATGGAGCATGTGAGGGTGGCCAGCACTGTCAGGGGAGGCTTCAGAAA...
pathogenic
181,011
Gene mutation in MYO7A (myosin VIIA) at chromosome 11, position 77147888—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'MYO7A-related_disorder', 'Usher_syndrome_type_1']
TGCCACCCTCCTCCGAGCCTGTTTTCTCATGTGAAGTGAGGGGGCTGGAATGGGGGACTTCTGGGGTCTGTCCATGACTGACTTCTGCCTCTCATTCAGACCTGGTCCCCCGCAGTCACCAGCCAGCCATCTGTCCCATCAGAGGCTCCCTGCCACATCATTTGTGCCCGGCCCCTGTGTGAGGCACCGTGGCCTGAGATGTGGCCCTGGAGGCAGGGGGATGGCACAGATGGAGCATGTGAGGGTGGCCAGCACTGTCAGGGGAGGCTTCAGAAACTGGGAAACCTCCGAGCCAAGCCTCGAAGGCTAAGGAGAAAGAA...
TGCCACCCTCCTCCGAGCCTGTTTTCTCATGTGAAGTGAGGGGGCTGGAATGGGGGACTTCTGGGGTCTGTCCATGACTGACTTCTGCCTCTCATTCAGACCTGGTCCCCCGCAGTCACCAGCCAGCCATCTGTCCCATCAGAGGCTCCCTGCCACATCATTTGTGCCCGGCCCCTGTGTGAGGCACCGTGGCCTGAGATGTGGCCCTGGAGGCAGGGGGATGGCACAGATGGAGCATGTGAGGGTGGCCAGCACTGTCAGGGGAGGCTTCAGAAACTGGGAAACCTCCGAGCCAAGCCTCGAAGGCTAAGGAGAAAGAA...
pathogenic
181,012
Is chromosome 11, position 77155942, gene MYO7A (myosin VIIA) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic
GCATGGCATCAGCCTGTGCTGTGTGGGGATCATGGGCCAGACGGCTGAGCATCACATTATTAAGAAGAAAGTTTAGCTGGGCATGGTGGCACATGCCTAGAACCCCAGCTACTCGAGACGTGGAGGCAGGAGAATCTCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATTGAGCCACTGCACCCAGCCTGGGCGACAGAGCGAGACTCTGCCTCAAAAGAGAGAAAGGAAGGTGGCGTTTATGTATCAGGCGCCTGGCAAAGGTTATGTCTTTGCCCTTTAGTCTTTACAACAGCCAAGGGAGGTGGGTGTTAA...
GCATGGCATCAGCCTGTGCTGTGTGGGGATCATGGGCCAGACGGCTGAGCATCACATTATTAAGAAGAAAGTTTAGCTGGGCATGGTGGCACATGCCTAGAACCCCAGCTACTCGAGACGTGGAGGCAGGAGAATCTCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATTGAGCCACTGCACCCAGCCTGGGCGACAGAGCGAGACTCTGCCTCAAAAGAGAGAAAGGAAGGTGGCGTTTATGTATCAGGCGCCTGGCAAAGGTTATGTCTTTGCCCTTTAGTCTTTACAACAGCCAAGGGAGGTGGGTGTTAA...
pathogenic
181,021
Variant at chromosome 11, position 77155955, gene MYO7A (myosin VIIA): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
CTGTGCTGTGTGGGGATCATGGGCCAGACGGCTGAGCATCACATTATTAAGAAGAAAGTTTAGCTGGGCATGGTGGCACATGCCTAGAACCCCAGCTACTCGAGACGTGGAGGCAGGAGAATCTCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATTGAGCCACTGCACCCAGCCTGGGCGACAGAGCGAGACTCTGCCTCAAAAGAGAGAAAGGAAGGTGGCGTTTATGTATCAGGCGCCTGGCAAAGGTTATGTCTTTGCCCTTTAGTCTTTACAACAGCCAAGGGAGGTGGGTGTTAACCTCCCCTTTTAC...
CTGTGCTGTGTGGGGATCATGGGCCAGACGGCTGAGCATCACATTATTAAGAAGAAAGTTTAGCTGGGCATGGTGGCACATGCCTAGAACCCCAGCTACTCGAGACGTGGAGGCAGGAGAATCTCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATTGAGCCACTGCACCCAGCCTGGGCGACAGAGCGAGACTCTGCCTCAAAAGAGAGAAAGGAAGGTGGCGTTTATGTATCAGGCGCCTGGCAAAGGTTATGTCTTTGCCCTTTAGTCTTTACAACAGCCAAGGGAGGTGGGTGTTAACCTCCCCTTTTAC...
pathogenic
181,024
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 11, position 77156011, gene MYO7A (myosin VIIA). What disease(s) is it linked to if pathogenic?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Hearing_loss,_autosomal_recessive', 'MYO7A-related_disorder', 'Rare_genetic_deafness', 'Usher_syndrome', 'Usher_syndrome_type_1']
AGTTTAGCTGGGCATGGTGGCACATGCCTAGAACCCCAGCTACTCGAGACGTGGAGGCAGGAGAATCTCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATTGAGCCACTGCACCCAGCCTGGGCGACAGAGCGAGACTCTGCCTCAAAAGAGAGAAAGGAAGGTGGCGTTTATGTATCAGGCGCCTGGCAAAGGTTATGTCTTTGCCCTTTAGTCTTTACAACAGCCAAGGGAGGTGGGTGTTAACCTCCCCTTTTACAAATTAGCAAACTGAGGTTTGCCAAAGGGATGTTCTTTGGGGCTGGTTCCTAGTCT...
AGTTTAGCTGGGCATGGTGGCACATGCCTAGAACCCCAGCTACTCGAGACGTGGAGGCAGGAGAATCTCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATTGAGCCACTGCACCCAGCCTGGGCGACAGAGCGAGACTCTGCCTCAAAAGAGAGAAAGGAAGGTGGCGTTTATGTATCAGGCGCCTGGCAAAGGTTATGTCTTTGCCCTTTAGTCTTTACAACAGCCAAGGGAGGTGGGTGTTAACCTCCCCTTTTACAAATTAGCAAACTGAGGTTTGCCAAAGGGATGTTCTTTGGGGCTGGTTCCTAGTCT...
pathogenic
181,026
Mutation at chromosome 11, position 77156011, within MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Retinal_dystrophy']
AGTTTAGCTGGGCATGGTGGCACATGCCTAGAACCCCAGCTACTCGAGACGTGGAGGCAGGAGAATCTCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATTGAGCCACTGCACCCAGCCTGGGCGACAGAGCGAGACTCTGCCTCAAAAGAGAGAAAGGAAGGTGGCGTTTATGTATCAGGCGCCTGGCAAAGGTTATGTCTTTGCCCTTTAGTCTTTACAACAGCCAAGGGAGGTGGGTGTTAACCTCCCCTTTTACAAATTAGCAAACTGAGGTTTGCCAAAGGGATGTTCTTTGGGGCTGGTTCCTAGTCT...
AGTTTAGCTGGGCATGGTGGCACATGCCTAGAACCCCAGCTACTCGAGACGTGGAGGCAGGAGAATCTCTTGAACCCAGGAGATGGAGGTTGCAGTGAGCTGAGATTGAGCCACTGCACCCAGCCTGGGCGACAGAGCGAGACTCTGCCTCAAAAGAGAGAAAGGAAGGTGGCGTTTATGTATCAGGCGCCTGGCAAAGGTTATGTCTTTGCCCTTTAGTCTTTACAACAGCCAAGGGAGGTGGGTGTTAACCTCCCCTTTTACAAATTAGCAAACTGAGGTTTGCCAAAGGGATGTTCTTTGGGGCTGGTTCCTAGTCT...
pathogenic
181,027
Gene MYO7A (myosin VIIA) variant at chromosome position 77156683 on chromosome 11: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Hearing_loss,_autosomal_recessive', 'Rare_genetic_deafness', 'Usher_syndrome_type_1']
CCCCAGCTCTTCCTGCTTGGCTCTTGTGGTACGGTTAGTAGGTCAGCACAGTGAGGCTCAAGTGCTTCTCTCCATGGGTTGATTGGAGGAAGAGGCTTAGGTGGGAAAGGAAGGTCTTCCTGGGCCCAGGGGCCCAGAGAAGGGCAGTTTCTGGCCAGCCCTCCTGGTCCAGGCCAGCCAAGGCCAGGACTGGAGCCTGGGTCTTGGCCCCACCTGGCCCCAGGGTGGGCATTTCCCCTGGCATGCGGTGCCTGCATCCACACTCTCCCTGCGTGGCCACAGTAGGCTGAGGCTGCTGGGGCATAGCTGCGGCTCTGCTG...
CCCCAGCTCTTCCTGCTTGGCTCTTGTGGTACGGTTAGTAGGTCAGCACAGTGAGGCTCAAGTGCTTCTCTCCATGGGTTGATTGGAGGAAGAGGCTTAGGTGGGAAAGGAAGGTCTTCCTGGGCCCAGGGGCCCAGAGAAGGGCAGTTTCTGGCCAGCCCTCCTGGTCCAGGCCAGCCAAGGCCAGGACTGGAGCCTGGGTCTTGGCCCCACCTGGCCCCAGGGTGGGCATTTCCCCTGGCATGCGGTGCCTGCATCCACACTCTCCCTGCGTGGCCACAGTAGGCTGAGGCTGCTGGGGCATAGCTGCGGCTCTGCTG...
pathogenic
181,040
Classify the chromosome 11 variant at position 77156766 affecting gene MYO7A (myosin VIIA) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Rare_genetic_deafness']
TGGAGGAAGAGGCTTAGGTGGGAAAGGAAGGTCTTCCTGGGCCCAGGGGCCCAGAGAAGGGCAGTTTCTGGCCAGCCCTCCTGGTCCAGGCCAGCCAAGGCCAGGACTGGAGCCTGGGTCTTGGCCCCACCTGGCCCCAGGGTGGGCATTTCCCCTGGCATGCGGTGCCTGCATCCACACTCTCCCTGCGTGGCCACAGTAGGCTGAGGCTGCTGGGGCATAGCTGCGGCTCTGCTGTGATGCACTGAGCCCTGAATGGGAGGGGGAGGGCAGGTTGTCACCTCCCCTGGACATCTTTCTTCAGCCTCTCCAGGCCCCGG...
TGGAGGAAGAGGCTTAGGTGGGAAAGGAAGGTCTTCCTGGGCCCAGGGGCCCAGAGAAGGGCAGTTTCTGGCCAGCCCTCCTGGTCCAGGCCAGCCAAGGCCAGGACTGGAGCCTGGGTCTTGGCCCCACCTGGCCCCAGGGTGGGCATTTCCCCTGGCATGCGGTGCCTGCATCCACACTCTCCCTGCGTGGCCACAGTAGGCTGAGGCTGCTGGGGCATAGCTGCGGCTCTGCTGTGATGCACTGAGCCCTGAATGGGAGGGGGAGGGCAGGTTGTCACCTCCCCTGGACATCTTTCTTCAGCCTCTCCAGGCCCCGG...
pathogenic
181,042
Mutation at chromosome 11, position 77156872, within MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
CTGGAGCCTGGGTCTTGGCCCCACCTGGCCCCAGGGTGGGCATTTCCCCTGGCATGCGGTGCCTGCATCCACACTCTCCCTGCGTGGCCACAGTAGGCTGAGGCTGCTGGGGCATAGCTGCGGCTCTGCTGTGATGCACTGAGCCCTGAATGGGAGGGGGAGGGCAGGTTGTCACCTCCCCTGGACATCTTTCTTCAGCCTCTCCAGGCCCCGGATATCAATACATCCACTGCCAATTATGGTCTAGGCCTGCCTGACCTTTTCAAGTTTGAGACGTGGGGTGGGAGGAGGGAGAAGTAACCCTGAGTGCCTCACCCTGC...
CTGGAGCCTGGGTCTTGGCCCCACCTGGCCCCAGGGTGGGCATTTCCCCTGGCATGCGGTGCCTGCATCCACACTCTCCCTGCGTGGCCACAGTAGGCTGAGGCTGCTGGGGCATAGCTGCGGCTCTGCTGTGATGCACTGAGCCCTGAATGGGAGGGGGAGGGCAGGTTGTCACCTCCCCTGGACATCTTTCTTCAGCCTCTCCAGGCCCCGGATATCAATACATCCACTGCCAATTATGGTCTAGGCCTGCCTGACCTTTTCAAGTTTGAGACGTGGGGTGGGAGGAGGGAGAAGTAACCCTGAGTGCCTCACCCTGC...
pathogenic
181,044
Does the chromosome 11 mutation at position 77157263 within gene MYO7A (myosin VIIA) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
ACAGACAGCTGATCTTTGCACTAACAGAGGAGCCCAAGTAGAGAACCTCCTTAAGGCTATCTGAGGTGCACCTGGCCCCTGCGCCTACGCTGCCCAGGATGGCTGGAGGTGCTCTGTCCCCTAGAGCACAGCATCTCCCTCTGTCCTGGGGCAGTGCTACAGAGAGTGGGGCCCACCCAGCCCCCAAGCCACTTACCCCAGCTCCTTCAGCTCTTTATGGCTAATTTCTCACGCCCCTCTTCCTCACCAACCTGGCCTCCCTCTGGACATGGTCCCGTTGATTAATTTCGCTCTAAAAGTTTGGGATACAGGGCCTGGAG...
ACAGACAGCTGATCTTTGCACTAACAGAGGAGCCCAAGTAGAGAACCTCCTTAAGGCTATCTGAGGTGCACCTGGCCCCTGCGCCTACGCTGCCCAGGATGGCTGGAGGTGCTCTGTCCCCTAGAGCACAGCATCTCCCTCTGTCCTGGGGCAGTGCTACAGAGAGTGGGGCCCACCCAGCCCCCAAGCCACTTACCCCAGCTCCTTCAGCTCTTTATGGCTAATTTCTCACGCCCCTCTTCCTCACCAACCTGGCCTCCCTCTGGACATGGTCCCGTTGATTAATTTCGCTCTAAAAGTTTGGGATACAGGGCCTGGAG...
benign
181,060
Variant chromosome 11, position 77157387, gene MYO7A (myosin VIIA): benign or pathogenic? Disease(s)?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
AGCACAGCATCTCCCTCTGTCCTGGGGCAGTGCTACAGAGAGTGGGGCCCACCCAGCCCCCAAGCCACTTACCCCAGCTCCTTCAGCTCTTTATGGCTAATTTCTCACGCCCCTCTTCCTCACCAACCTGGCCTCCCTCTGGACATGGTCCCGTTGATTAATTTCGCTCTAAAAGTTTGGGATACAGGGCCTGGAGGCGATGGTGGGAGACAGCATTTGCAGAGTACCTAGTGTGTGCCACGAATTTTAAAAGATACCACCTCCTTTAATCTTCACAAACAGTTACGCTCATTTTACAGATGAAGAGAAGGAAATCTAGG...
AGCACAGCATCTCCCTCTGTCCTGGGGCAGTGCTACAGAGAGTGGGGCCCACCCAGCCCCCAAGCCACTTACCCCAGCTCCTTCAGCTCTTTATGGCTAATTTCTCACGCCCCTCTTCCTCACCAACCTGGCCTCCCTCTGGACATGGTCCCGTTGATTAATTTCGCTCTAAAAGTTTGGGATACAGGGCCTGGAGGCGATGGTGGGAGACAGCATTTGCAGAGTACCTAGTGTGTGCCACGAATTTTAAAAGATACCACCTCCTTTAATCTTCACAAACAGTTACGCTCATTTTACAGATGAAGAGAAGGAAATCTAGG...
pathogenic
181,065
Chromosome 11, position 77162125, gene MYO7A (myosin VIIA): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic
CCAGTGCCGGAAAGTGGAGGGATCCGGGTGTGGGTGGAGGGAGGGGCAGGCTGGCAGGTGAGCACCTGGGGTGTTGCCTGTACCAGGTGAACCCCCCAGACCTGATGAGCTGCCTGACTAGCCGCACCCTCATCACCCGCGGGGAGACGGTGTCCACCCCACTGAGCAGGGAACAGGCACTGGACGTGCGCGACGCCTTCGTAAAGGTGGGCTGGAGGGAAGGGGCCGCTTGCTCGCCCTACCCCTTGGGAAGTTGGGCTCTTGATGGGCAGGTGCCAAGGAGTCCTGGGAGGTGGGTAGACATCTGGGTCGCCACCCCT...
CCAGTGCCGGAAAGTGGAGGGATCCGGGTGTGGGTGGAGGGAGGGGCAGGCTGGCAGGTGAGCACCTGGGGTGTTGCCTGTACCAGGTGAACCCCCCAGACCTGATGAGCTGCCTGACTAGCCGCACCCTCATCACCCGCGGGGAGACGGTGTCCACCCCACTGAGCAGGGAACAGGCACTGGACGTGCGCGACGCCTTCGTAAAGGTGGGCTGGAGGGAAGGGGCCGCTTGCTCGCCCTACCCCTTGGGAAGTTGGGCTCTTGATGGGCAGGTGCCAAGGAGTCCTGGGAGGTGGGTAGACATCTGGGTCGCCACCCCT...
pathogenic
181,096
Is the genetic mutation found on chromosome 11 at position 77162130, within the gene MYO7A (myosin VIIA), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic
GCCGGAAAGTGGAGGGATCCGGGTGTGGGTGGAGGGAGGGGCAGGCTGGCAGGTGAGCACCTGGGGTGTTGCCTGTACCAGGTGAACCCCCCAGACCTGATGAGCTGCCTGACTAGCCGCACCCTCATCACCCGCGGGGAGACGGTGTCCACCCCACTGAGCAGGGAACAGGCACTGGACGTGCGCGACGCCTTCGTAAAGGTGGGCTGGAGGGAAGGGGCCGCTTGCTCGCCCTACCCCTTGGGAAGTTGGGCTCTTGATGGGCAGGTGCCAAGGAGTCCTGGGAGGTGGGTAGACATCTGGGTCGCCACCCCTGCCTG...
GCCGGAAAGTGGAGGGATCCGGGTGTGGGTGGAGGGAGGGGCAGGCTGGCAGGTGAGCACCTGGGGTGTTGCCTGTACCAGGTGAACCCCCCAGACCTGATGAGCTGCCTGACTAGCCGCACCCTCATCACCCGCGGGGAGACGGTGTCCACCCCACTGAGCAGGGAACAGGCACTGGACGTGCGCGACGCCTTCGTAAAGGTGGGCTGGAGGGAAGGGGCCGCTTGCTCGCCCTACCCCTTGGGAAGTTGGGCTCTTGATGGGCAGGTGCCAAGGAGTCCTGGGAGGTGGGTAGACATCTGGGTCGCCACCCCTGCCTG...
pathogenic
181,097
Chromosome 11, position 77162860, gene MYO7A (myosin VIIA): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Hearing_loss', 'Retinal_dystrophy', 'Usher_syndrome_type_1']
GGTCTCCAGGCAGAGGGAACAGCTCAAGTAAAGGGTTGGGGGTTTCACACGGCACTTTGTTCCACACAAGGGCTGGAGCGACACCACGAAGGGTCCAGGAGCCTGGCCTGTCCCCCGGGGGAGGGTGTGGCTGGTGCCAGTGGCTGATCACTGCCTTTCAGGGGATCTACGGGCGGCTGTTCGTGTGGATTGTGGACAAGATCAACGCAGCAATTTACAAGCCTCCCTCCCAGGATGTGAAGAACTCTCGCAGGTCCATCGGCCTCCTGGACATCTTTGGGTTTGAGAACTTTGCTGTGAACAGGTACCGCGTGGGGCTC...
GGTCTCCAGGCAGAGGGAACAGCTCAAGTAAAGGGTTGGGGGTTTCACACGGCACTTTGTTCCACACAAGGGCTGGAGCGACACCACGAAGGGTCCAGGAGCCTGGCCTGTCCCCCGGGGGAGGGTGTGGCTGGTGCCAGTGGCTGATCACTGCCTTTCAGGGGATCTACGGGCGGCTGTTCGTGTGGATTGTGGACAAGATCAACGCAGCAATTTACAAGCCTCCCTCCCAGGATGTGAAGAACTCTCGCAGGTCCATCGGCCTCCTGGACATCTTTGGGTTTGAGAACTTTGCTGTGAACAGGTACCGCGTGGGGCTC...
pathogenic
181,106
Evaluate this variant at chromosome 11, position 77162914, gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Inborn_genetic_diseases', 'Retinal_dystrophy', 'Usher_syndrome_type_1', 'Usher_syndrome_type_1B']
CTTTGTTCCACACAAGGGCTGGAGCGACACCACGAAGGGTCCAGGAGCCTGGCCTGTCCCCCGGGGGAGGGTGTGGCTGGTGCCAGTGGCTGATCACTGCCTTTCAGGGGATCTACGGGCGGCTGTTCGTGTGGATTGTGGACAAGATCAACGCAGCAATTTACAAGCCTCCCTCCCAGGATGTGAAGAACTCTCGCAGGTCCATCGGCCTCCTGGACATCTTTGGGTTTGAGAACTTTGCTGTGAACAGGTACCGCGTGGGGCTCTGCTCATGGGAATTTCCTTCCCCAATATGGAAATAAGAAATATCACGTCTCTCC...
CTTTGTTCCACACAAGGGCTGGAGCGACACCACGAAGGGTCCAGGAGCCTGGCCTGTCCCCCGGGGGAGGGTGTGGCTGGTGCCAGTGGCTGATCACTGCCTTTCAGGGGATCTACGGGCGGCTGTTCGTGTGGATTGTGGACAAGATCAACGCAGCAATTTACAAGCCTCCCTCCCAGGATGTGAAGAACTCTCGCAGGTCCATCGGCCTCCTGGACATCTTTGGGTTTGAGAACTTTGCTGTGAACAGGTACCGCGTGGGGCTCTGCTCATGGGAATTTCCTTCCCCAATATGGAAATAAGAAATATCACGTCTCTCC...
pathogenic
181,110
Evaluate the clinical significance of the mutation at chromosome 11, position 77166102 in gene MYO7A (myosin VIIA): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Retinal_dystrophy']
AGTTACCCCCTAAGACTCTCAGCAACAAGACCAAGCATGAGCTTTGAAGACCGTGCATCTTCTTTTCCCCTGGGGACAGGCAATTGGGTTCACGTTAAAGCTGGAAGTTAAGAAGAGTGGTCAGAACACAGGCTTATCTCACCTGGAATTCTTAAGGGTTTGTCAAAAGACTGCAGACTGCCCTTGCCAATCCCTCCCCACCCACCCTGGTGTAAAGGGCCAACCACAAATTGGCATTAGTTATGGGCTGTGTCTACCCTGAGCCCTGCCATACAGCCTCAAGGGGTCCCATGCATAGTCAAAGGCCAATTAACCCATAA...
AGTTACCCCCTAAGACTCTCAGCAACAAGACCAAGCATGAGCTTTGAAGACCGTGCATCTTCTTTTCCCCTGGGGACAGGCAATTGGGTTCACGTTAAAGCTGGAAGTTAAGAAGAGTGGTCAGAACACAGGCTTATCTCACCTGGAATTCTTAAGGGTTTGTCAAAAGACTGCAGACTGCCCTTGCCAATCCCTCCCCACCCACCCTGGTGTAAAGGGCCAACCACAAATTGGCATTAGTTATGGGCTGTGTCTACCCTGAGCCCTGCCATACAGCCTCAAGGGGTCCCATGCATAGTCAAAGGCCAATTAACCCATAA...
pathogenic
181,118
Does the chromosome 11 mutation at position 77172741 within gene MYO7A (myosin VIIA) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome', 'Usher_syndrome_type_1']
TTCACTAACTCCCCAGTCCCAGGGGAGGTTGGCCTGGAATGTGGGGGATGGAAGCAAAGAGACGAGTTGGGGGGTTGCTGCAGGAATTTGAGAGCAATGCTGGTGGCTGGGACCAGGCTGACGGTGGAGGAAGTGGTGAGGGGTCAGGTTCTGGAGATATTTTGAAAGTAGAGCCTGTAGGATTTGCGGATATATTAGATGTGACAGAAGAGGCACTGAGGACAGTTGCTAGATGTTTGGCTGGAGCAACGGGAAGGTGGGCAATTTCTGTGAACCCATGGATGTCACTAGGAACCAGTTCAACAGCACTTCAGTAGATC...
TTCACTAACTCCCCAGTCCCAGGGGAGGTTGGCCTGGAATGTGGGGGATGGAAGCAAAGAGACGAGTTGGGGGGTTGCTGCAGGAATTTGAGAGCAATGCTGGTGGCTGGGACCAGGCTGACGGTGGAGGAAGTGGTGAGGGGTCAGGTTCTGGAGATATTTTGAAAGTAGAGCCTGTAGGATTTGCGGATATATTAGATGTGACAGAAGAGGCACTGAGGACAGTTGCTAGATGTTTGGCTGGAGCAACGGGAAGGTGGGCAATTTCTGTGAACCCATGGATGTCACTAGGAACCAGTTCAACAGCACTTCAGTAGATC...
pathogenic
181,123
Does the variant impacting MYO7A (myosin VIIA) on chromosome 11, position 77172778, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
AATGTGGGGGATGGAAGCAAAGAGACGAGTTGGGGGGTTGCTGCAGGAATTTGAGAGCAATGCTGGTGGCTGGGACCAGGCTGACGGTGGAGGAAGTGGTGAGGGGTCAGGTTCTGGAGATATTTTGAAAGTAGAGCCTGTAGGATTTGCGGATATATTAGATGTGACAGAAGAGGCACTGAGGACAGTTGCTAGATGTTTGGCTGGAGCAACGGGAAGGTGGGCAATTTCTGTGAACCCATGGATGTCACTAGGAACCAGTTCAACAGCACTTCAGTAGATCAAAGTGTTGACTGTTACTTGTGTCATGTAGGCCCTGG...
AATGTGGGGGATGGAAGCAAAGAGACGAGTTGGGGGGTTGCTGCAGGAATTTGAGAGCAATGCTGGTGGCTGGGACCAGGCTGACGGTGGAGGAAGTGGTGAGGGGTCAGGTTCTGGAGATATTTTGAAAGTAGAGCCTGTAGGATTTGCGGATATATTAGATGTGACAGAAGAGGCACTGAGGACAGTTGCTAGATGTTTGGCTGGAGCAACGGGAAGGTGGGCAATTTCTGTGAACCCATGGATGTCACTAGGAACCAGTTCAACAGCACTTCAGTAGATCAAAGTGTTGACTGTTACTTGTGTCATGTAGGCCCTGG...
pathogenic
181,127
Gene mutation in MYO7A (myosin VIIA) at chromosome 11, position 77174772—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Rare_genetic_deafness']
CATCGCTGCCGTCCGTCCCCCCAGGGCGCCGAGACCAGGAAGCGCTCGCCCACACTTAGCAGCCAGTTCAAGCGGTCACTGGAGCTGCTGATGCGCACGCTGGGTGCCTGCCAGCCCTTCTTTGTGCGATGCATCAAGCCCAATGAGTTCAAGAAGCCCATGGTGAGTGGCCCTGGCCTGGGGTTGGCGGGTGGCGGCTAGGGTGACGTGGAGGAGCTAGGTCAAGAATAAGGTAGGGTGGGAGTGAAGGATGTGAGACTTTGTCCCTTTGGGGAATGGGGGGCACCCCGGGAGCTTACAAAACAAGGCCCCCTATTTAT...
CATCGCTGCCGTCCGTCCCCCCAGGGCGCCGAGACCAGGAAGCGCTCGCCCACACTTAGCAGCCAGTTCAAGCGGTCACTGGAGCTGCTGATGCGCACGCTGGGTGCCTGCCAGCCCTTCTTTGTGCGATGCATCAAGCCCAATGAGTTCAAGAAGCCCATGGTGAGTGGCCCTGGCCTGGGGTTGGCGGGTGGCGGCTAGGGTGACGTGGAGGAGCTAGGTCAAGAATAAGGTAGGGTGGGAGTGAAGGATGTGAGACTTTGTCCCTTTGGGGAATGGGGGGCACCCCGGGAGCTTACAAAACAAGGCCCCCTATTTAT...
pathogenic
181,133
Is the genetic mutation found on chromosome 11 at position 77175447, within the gene MYO7A (myosin VIIA), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Rare_genetic_deafness']
TTTCTGAATAACATTTGTTGGGCCCTTTCTGTGTGCCCAGCATAGGCTGGATGGTCAGTCCACAGCCTCCTTCAACCTTCTCAAACAGCCCGTGAGAAAGGGACTGTGCTGGTCCCAGGTTAGAGATGCGGGACTGGGGGCTCAGGGAGGTTAAGGGGCTCAGGCTGGGGCCACCTCGCTGCGAGCCCTCTCCTTTCGCAGCACAGGCTCTGGGAGGGTTGTTTACCCAGAGGCCTGCAGGGAGGCACAGGGGGAAGCTGGGGCCTCGGGATCTGGGGAGGGAAGGAAGGCCGGGGAAAGTGGCCCGGAGAGAGAGGAAA...
TTTCTGAATAACATTTGTTGGGCCCTTTCTGTGTGCCCAGCATAGGCTGGATGGTCAGTCCACAGCCTCCTTCAACCTTCTCAAACAGCCCGTGAGAAAGGGACTGTGCTGGTCCCAGGTTAGAGATGCGGGACTGGGGGCTCAGGGAGGTTAAGGGGCTCAGGCTGGGGCCACCTCGCTGCGAGCCCTCTCCTTTCGCAGCACAGGCTCTGGGAGGGTTGTTTACCCAGAGGCCTGCAGGGAGGCACAGGGGGAAGCTGGGGCCTCGGGATCTGGGGAGGGAAGGAAGGCCGGGGAAAGTGGCCCGGAGAGAGAGGAAA...
pathogenic
181,153
The mutation in gene MYO7A (myosin VIIA) at chromosome 11, position 77175465—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
TGGGCCCTTTCTGTGTGCCCAGCATAGGCTGGATGGTCAGTCCACAGCCTCCTTCAACCTTCTCAAACAGCCCGTGAGAAAGGGACTGTGCTGGTCCCAGGTTAGAGATGCGGGACTGGGGGCTCAGGGAGGTTAAGGGGCTCAGGCTGGGGCCACCTCGCTGCGAGCCCTCTCCTTTCGCAGCACAGGCTCTGGGAGGGTTGTTTACCCAGAGGCCTGCAGGGAGGCACAGGGGGAAGCTGGGGCCTCGGGATCTGGGGAGGGAAGGAAGGCCGGGGAAAGTGGCCCGGAGAGAGAGGAAACAGTCTCCGGAAGCTGAC...
TGGGCCCTTTCTGTGTGCCCAGCATAGGCTGGATGGTCAGTCCACAGCCTCCTTCAACCTTCTCAAACAGCCCGTGAGAAAGGGACTGTGCTGGTCCCAGGTTAGAGATGCGGGACTGGGGGCTCAGGGAGGTTAAGGGGCTCAGGCTGGGGCCACCTCGCTGCGAGCCCTCTCCTTTCGCAGCACAGGCTCTGGGAGGGTTGTTTACCCAGAGGCCTGCAGGGAGGCACAGGGGGAAGCTGGGGCCTCGGGATCTGGGGAGGGAAGGAAGGCCGGGGAAAGTGGCCCGGAGAGAGAGGAAACAGTCTCCGGAAGCTGAC...
pathogenic
181,155
Determine whether the variant at chromosome 11, position 77177612, in gene MYO7A (myosin VIIA) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Usher_syndrome_type_1']
AGATCCTTTCTGCCGGGCTGTGGTGTGGCTGGAGGAGCAGGTGGGATCTGGCCTCTCTGGTGGGGAAGGGTAATTTGGTGTTTGAGATCATCTACAACCTGGGAGTGGGGTCAGAGCACTGACCACAGGTTACAAAGCACATGCCAGGGGCGGGCTGGCTGTTAGGCCCACAGCAGGGAGGCAGGGGTGCTGCTTGCCTTGGGGCCCTTTCTGAGCCTCATTTTCCCATCTGTAAATTGGGGTGTGCCTGTGTGGGGTCTCTTGAGTGTATCTTTAGGTTCCTTCCTGTGGTTTCCTGCCTGGCAGGGCCCATCCCGTGC...
AGATCCTTTCTGCCGGGCTGTGGTGTGGCTGGAGGAGCAGGTGGGATCTGGCCTCTCTGGTGGGGAAGGGTAATTTGGTGTTTGAGATCATCTACAACCTGGGAGTGGGGTCAGAGCACTGACCACAGGTTACAAAGCACATGCCAGGGGCGGGCTGGCTGTTAGGCCCACAGCAGGGAGGCAGGGGTGCTGCTTGCCTTGGGGCCCTTTCTGAGCCTCATTTTCCCATCTGTAAATTGGGGTGTGCCTGTGTGGGGTCTCTTGAGTGTATCTTTAGGTTCCTTCCTGTGGTTTCCTGCCTGGCAGGGCCCATCCCGTGC...
pathogenic
181,159
Clinically, how would you classify the variant at chromosome 11, position 77179038, gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
TGGGTGGCCTTGAATGCCAGGGTGAGGAACCCAGGCTCGACGTGGGGAACCATGAGGTGTCACTGTAGGGTCACCATCCAGGTTGTGTTGAGGAGGGTCCCTCTGGCTGCTTGTGAAGGAGCGCCAGAGAGGGAGCCAGGAGGCCGCGAGACCTTTAGTTAGGAGGCTGCTGCCAAGGTTCGGGAGAAGAATGGCAACAGCCCAGCCCAGGTGAGGGACTGATGTGACAGGGACGTCTAGAAGCAGGGGGCTTGGGCAGATTGACGATAGGGAAGAAGCTGGTGTGTGTGCATACTGGGCCTTCCGACCCCATCCAGAGA...
TGGGTGGCCTTGAATGCCAGGGTGAGGAACCCAGGCTCGACGTGGGGAACCATGAGGTGTCACTGTAGGGTCACCATCCAGGTTGTGTTGAGGAGGGTCCCTCTGGCTGCTTGTGAAGGAGCGCCAGAGAGGGAGCCAGGAGGCCGCGAGACCTTTAGTTAGGAGGCTGCTGCCAAGGTTCGGGAGAAGAATGGCAACAGCCCAGCCCAGGTGAGGGACTGATGTGACAGGGACGTCTAGAAGCAGGGGGCTTGGGCAGATTGACGATAGGGAAGAAGCTGGTGTGTGTGCATACTGGGCCTTCCGACCCCATCCAGAGA...
pathogenic
181,161
Regarding the variant found on chromosome 11 at position 77179068 in gene MYO7A (myosin VIIA): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
CCAGGCTCGACGTGGGGAACCATGAGGTGTCACTGTAGGGTCACCATCCAGGTTGTGTTGAGGAGGGTCCCTCTGGCTGCTTGTGAAGGAGCGCCAGAGAGGGAGCCAGGAGGCCGCGAGACCTTTAGTTAGGAGGCTGCTGCCAAGGTTCGGGAGAAGAATGGCAACAGCCCAGCCCAGGTGAGGGACTGATGTGACAGGGACGTCTAGAAGCAGGGGGCTTGGGCAGATTGACGATAGGGAAGAAGCTGGTGTGTGTGCATACTGGGCCTTCCGACCCCATCCAGAGAGATTAGGCACCTTCTGCTCCATTTGTCCTG...
CCAGGCTCGACGTGGGGAACCATGAGGTGTCACTGTAGGGTCACCATCCAGGTTGTGTTGAGGAGGGTCCCTCTGGCTGCTTGTGAAGGAGCGCCAGAGAGGGAGCCAGGAGGCCGCGAGACCTTTAGTTAGGAGGCTGCTGCCAAGGTTCGGGAGAAGAATGGCAACAGCCCAGCCCAGGTGAGGGACTGATGTGACAGGGACGTCTAGAAGCAGGGGGCTTGGGCAGATTGACGATAGGGAAGAAGCTGGTGTGTGTGCATACTGGGCCTTCCGACCCCATCCAGAGAGATTAGGCACCTTCTGCTCCATTTGTCCTG...
pathogenic
181,163
Evaluate this variant at chromosome 11, position 77181434, gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2']
GAGATCTCAGACAGGGTGAGAGTGGCTGGGTCACATGGACCTCTGTGCAGCAGCTGGGCTTAGGACTTGTTGGGGCTGGATGGGAAGCAGACTGGTTGGTTGCAGCTCCTGATCTAGGATTCTCTTGGGGGCCCCAACTCAGGGAGAGTCAAGGTCACCTAAAAATATGTTGCCTGAGAGGAAACAGAACTTTCTAACGATGGGGGGGCACTAATCTGAGAGGAGACTGGGCCACGCCTTCTGGGGGTGCCTGTCTGAGAGTGGAGGCCGGTGCCATGGAAGCTCCTGCAGGCAGGGTCAGTCTGGAATGGGACAGCAGG...
GAGATCTCAGACAGGGTGAGAGTGGCTGGGTCACATGGACCTCTGTGCAGCAGCTGGGCTTAGGACTTGTTGGGGCTGGATGGGAAGCAGACTGGTTGGTTGCAGCTCCTGATCTAGGATTCTCTTGGGGGCCCCAACTCAGGGAGAGTCAAGGTCACCTAAAAATATGTTGCCTGAGAGGAAACAGAACTTTCTAACGATGGGGGGGCACTAATCTGAGAGGAGACTGGGCCACGCCTTCTGGGGGTGCCTGTCTGAGAGTGGAGGCCGGTGCCATGGAAGCTCCTGCAGGCAGGGTCAGTCTGGAATGGGACAGCAGG...
pathogenic
181,182
Gene MYO7A (myosin VIIA) variant at chromosome 11, position 77181450—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Usher_syndrome_type_1']
TGAGAGTGGCTGGGTCACATGGACCTCTGTGCAGCAGCTGGGCTTAGGACTTGTTGGGGCTGGATGGGAAGCAGACTGGTTGGTTGCAGCTCCTGATCTAGGATTCTCTTGGGGGCCCCAACTCAGGGAGAGTCAAGGTCACCTAAAAATATGTTGCCTGAGAGGAAACAGAACTTTCTAACGATGGGGGGGCACTAATCTGAGAGGAGACTGGGCCACGCCTTCTGGGGGTGCCTGTCTGAGAGTGGAGGCCGGTGCCATGGAAGCTCCTGCAGGCAGGGTCAGTCTGGAATGGGACAGCAGGCTCTGAGCATGGGGTG...
TGAGAGTGGCTGGGTCACATGGACCTCTGTGCAGCAGCTGGGCTTAGGACTTGTTGGGGCTGGATGGGAAGCAGACTGGTTGGTTGCAGCTCCTGATCTAGGATTCTCTTGGGGGCCCCAACTCAGGGAGAGTCAAGGTCACCTAAAAATATGTTGCCTGAGAGGAAACAGAACTTTCTAACGATGGGGGGGCACTAATCTGAGAGGAGACTGGGCCACGCCTTCTGGGGGTGCCTGTCTGAGAGTGGAGGCCGGTGCCATGGAAGCTCCTGCAGGCAGGGTCAGTCTGGAATGGGACAGCAGGCTCTGAGCATGGGGTG...
pathogenic
181,184
The mutation impacting MYO7A (myosin VIIA) on chromosome 11 at position 77181522: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['MYO7A-related_disorder']
AGACTGGTTGGTTGCAGCTCCTGATCTAGGATTCTCTTGGGGGCCCCAACTCAGGGAGAGTCAAGGTCACCTAAAAATATGTTGCCTGAGAGGAAACAGAACTTTCTAACGATGGGGGGGCACTAATCTGAGAGGAGACTGGGCCACGCCTTCTGGGGGTGCCTGTCTGAGAGTGGAGGCCGGTGCCATGGAAGCTCCTGCAGGCAGGGTCAGTCTGGAATGGGACAGCAGGCTCTGAGCATGGGGTGGCTGTCCTTGCAGATGCGTCTGGGCTTCCTGCGGCTGCAGGCCCTGCACCGCTCCCGGAAGCTGCACCAGCA...
AGACTGGTTGGTTGCAGCTCCTGATCTAGGATTCTCTTGGGGGCCCCAACTCAGGGAGAGTCAAGGTCACCTAAAAATATGTTGCCTGAGAGGAAACAGAACTTTCTAACGATGGGGGGGCACTAATCTGAGAGGAGACTGGGCCACGCCTTCTGGGGGTGCCTGTCTGAGAGTGGAGGCCGGTGCCATGGAAGCTCCTGCAGGCAGGGTCAGTCTGGAATGGGACAGCAGGCTCTGAGCATGGGGTGGCTGTCCTTGCAGATGCGTCTGGGCTTCCTGCGGCTGCAGGCCCTGCACCGCTCCCGGAAGCTGCACCAGCA...
pathogenic
181,186
Variant in MYO7A (myosin VIIA), chromosome 11, position 77184725—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
benign
TCCTCTGCAGAAAAAGGATCCTATAATTCATCTCTGCCTCACCGACCCCTGCCTGCCACCCTCCTTTGTCTACTTGTGGGAACAAATGTGTGCAACTTTTATAAACTGTAAAGTGCTGACCATAACTGAGGGGCCTCATGGCAGAGCAGACAGGGGCTTTGCAGTTGGAGCCAGCTCCCGTACTATGTTTTTCTGAGTCTCAGTTTTCCTGACTGCCAGTTGGCTAGTGGGGGTGCAAGGGTAGGGGTGAGCAGGTGGACGGTGGCAGTGTGGGGGACACCCTGTAAGCTTCACGTGGAAGCGAGACGGTTCCCCGCAAA...
TCCTCTGCAGAAAAAGGATCCTATAATTCATCTCTGCCTCACCGACCCCTGCCTGCCACCCTCCTTTGTCTACTTGTGGGAACAAATGTGTGCAACTTTTATAAACTGTAAAGTGCTGACCATAACTGAGGGGCCTCATGGCAGAGCAGACAGGGGCTTTGCAGTTGGAGCCAGCTCCCGTACTATGTTTTTCTGAGTCTCAGTTTTCCTGACTGCCAGTTGGCTAGTGGGGGTGCAAGGGTAGGGGTGAGCAGGTGGACGGTGGCAGTGTGGGGGACACCCTGTAAGCTTCACGTGGAAGCGAGACGGTTCCCCGCAAA...
benign
181,216
Clinical significance of chromosome 11, position 77189371, gene MYO7A (myosin VIIA): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Rare_genetic_deafness']
GTCTGCAAAGTGTAATAAAGTGAAGTACAGTAAAATGAGGTGTGCCTGCAGTAGCTACCTCATACATAGGCTTGTGGGAAGATAAAGCTATGAAAACTGTGTAGCACCAGACCTGGAGCATAGTAAGCGCCCCGTAGATGGTAGCTTTGATCATCATCATCCAACATGCATTTCCTGCTTTAACCCCGCTGCCGCCAGCTCACCTCCAGTCACCCACCCTAGGCCCACGGTTAAGGTTACTGTGCCTGGGAATCCTGCAAGTACCTCCTTCCCCACAGGGCCAGGAGAGGCCTTTACCCAGGTCCCTGGGGTTTTGGGGA...
GTCTGCAAAGTGTAATAAAGTGAAGTACAGTAAAATGAGGTGTGCCTGCAGTAGCTACCTCATACATAGGCTTGTGGGAAGATAAAGCTATGAAAACTGTGTAGCACCAGACCTGGAGCATAGTAAGCGCCCCGTAGATGGTAGCTTTGATCATCATCATCCAACATGCATTTCCTGCTTTAACCCCGCTGCCGCCAGCTCACCTCCAGTCACCCACCCTAGGCCCACGGTTAAGGTTACTGTGCCTGGGAATCCTGCAAGTACCTCCTTCCCCACAGGGCCAGGAGAGGCCTTTACCCAGGTCCCTGGGGTTTTGGGGA...
pathogenic
181,220
Clinical impact (benign or pathogenic) of the variant at chromosome 11, location 77189380, gene MYO7A (myosin VIIA): what disease(s) if pathogenic?
pathogenic; ['Rare_genetic_deafness']
GTGTAATAAAGTGAAGTACAGTAAAATGAGGTGTGCCTGCAGTAGCTACCTCATACATAGGCTTGTGGGAAGATAAAGCTATGAAAACTGTGTAGCACCAGACCTGGAGCATAGTAAGCGCCCCGTAGATGGTAGCTTTGATCATCATCATCCAACATGCATTTCCTGCTTTAACCCCGCTGCCGCCAGCTCACCTCCAGTCACCCACCCTAGGCCCACGGTTAAGGTTACTGTGCCTGGGAATCCTGCAAGTACCTCCTTCCCCACAGGGCCAGGAGAGGCCTTTACCCAGGTCCCTGGGGTTTTGGGGAGTTGAAGGG...
GTGTAATAAAGTGAAGTACAGTAAAATGAGGTGTGCCTGCAGTAGCTACCTCATACATAGGCTTGTGGGAAGATAAAGCTATGAAAACTGTGTAGCACCAGACCTGGAGCATAGTAAGCGCCCCGTAGATGGTAGCTTTGATCATCATCATCCAACATGCATTTCCTGCTTTAACCCCGCTGCCGCCAGCTCACCTCCAGTCACCCACCCTAGGCCCACGGTTAAGGTTACTGTGCCTGGGAATCCTGCAAGTACCTCCTTCCCCACAGGGCCAGGAGAGGCCTTTACCCAGGTCCCTGGGGTTTTGGGGAGTTGAAGGG...
pathogenic
181,221
A mutation at chromosome position 77189425 on chromosome 11 in gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Rare_genetic_deafness', 'Usher_syndrome']
CTACCTCATACATAGGCTTGTGGGAAGATAAAGCTATGAAAACTGTGTAGCACCAGACCTGGAGCATAGTAAGCGCCCCGTAGATGGTAGCTTTGATCATCATCATCCAACATGCATTTCCTGCTTTAACCCCGCTGCCGCCAGCTCACCTCCAGTCACCCACCCTAGGCCCACGGTTAAGGTTACTGTGCCTGGGAATCCTGCAAGTACCTCCTTCCCCACAGGGCCAGGAGAGGCCTTTACCCAGGTCCCTGGGGTTTTGGGGAGTTGAAGGGAAGACCCAGGAGTCACCAGGAGCCACCAAAAAATCAACTCAGCTG...
CTACCTCATACATAGGCTTGTGGGAAGATAAAGCTATGAAAACTGTGTAGCACCAGACCTGGAGCATAGTAAGCGCCCCGTAGATGGTAGCTTTGATCATCATCATCCAACATGCATTTCCTGCTTTAACCCCGCTGCCGCCAGCTCACCTCCAGTCACCCACCCTAGGCCCACGGTTAAGGTTACTGTGCCTGGGAATCCTGCAAGTACCTCCTTCCCCACAGGGCCAGGAGAGGCCTTTACCCAGGTCCCTGGGGTTTTGGGGAGTTGAAGGGAAGACCCAGGAGTCACCAGGAGCCACCAAAAAATCAACTCAGCTG...
pathogenic
181,225
Assess the variant on chromosome 11, position 77190083, impacting MYO7A (myosin VIIA): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Rare_genetic_deafness', 'Usher_syndrome_type_1', 'Usher_syndrome_type_1B']
TTATCTCACCATCATACCTAAAGCTGACACTTCTAGGAAACACGGTGCCAGGAGCCCTGAACCAAGAGTCCAAAGGCTGGGGTGTCAACTCCTTGAGGGGCCTCACACGGCTAATCCCTCCCTGCTCTCAGCCTCTGTCTCCCCATCTGTAAAGTGAGTGGAGACTCCCAGCTGCAGGTGATAATATCTCACTAGTCTGTGGCAAGGTGGGAAAAGGAGGGATGTTTCTGAAGCTAAACTTGTTTTCTTTAAAGGACTGCTCTGAGACTTTGCCCTCCTACTGTTTGGAAATTTAAAATTACCTTTGTTTTATGAGATAA...
TTATCTCACCATCATACCTAAAGCTGACACTTCTAGGAAACACGGTGCCAGGAGCCCTGAACCAAGAGTCCAAAGGCTGGGGTGTCAACTCCTTGAGGGGCCTCACACGGCTAATCCCTCCCTGCTCTCAGCCTCTGTCTCCCCATCTGTAAAGTGAGTGGAGACTCCCAGCTGCAGGTGATAATATCTCACTAGTCTGTGGCAAGGTGGGAAAAGGAGGGATGTTTCTGAAGCTAAACTTGTTTTCTTTAAAGGACTGCTCTGAGACTTTGCCCTCCTACTGTTTGGAAATTTAAAATTACCTTTGTTTTATGAGATAA...
pathogenic
181,231
Clinical significance of chromosome 11, position 77190115, gene MYO7A (myosin VIIA): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Rare_genetic_deafness', 'Usher_syndrome', 'Usher_syndrome_type_1']
CTAGGAAACACGGTGCCAGGAGCCCTGAACCAAGAGTCCAAAGGCTGGGGTGTCAACTCCTTGAGGGGCCTCACACGGCTAATCCCTCCCTGCTCTCAGCCTCTGTCTCCCCATCTGTAAAGTGAGTGGAGACTCCCAGCTGCAGGTGATAATATCTCACTAGTCTGTGGCAAGGTGGGAAAAGGAGGGATGTTTCTGAAGCTAAACTTGTTTTCTTTAAAGGACTGCTCTGAGACTTTGCCCTCCTACTGTTTGGAAATTTAAAATTACCTTTGTTTTATGAGATAATTGGGATCTAGATAGTGGGCAGGTTGTGTGTG...
CTAGGAAACACGGTGCCAGGAGCCCTGAACCAAGAGTCCAAAGGCTGGGGTGTCAACTCCTTGAGGGGCCTCACACGGCTAATCCCTCCCTGCTCTCAGCCTCTGTCTCCCCATCTGTAAAGTGAGTGGAGACTCCCAGCTGCAGGTGATAATATCTCACTAGTCTGTGGCAAGGTGGGAAAAGGAGGGATGTTTCTGAAGCTAAACTTGTTTTCTTTAAAGGACTGCTCTGAGACTTTGCCCTCCTACTGTTTGGAAATTTAAAATTACCTTTGTTTTATGAGATAATTGGGATCTAGATAGTGGGCAGGTTGTGTGTG...
pathogenic
181,235
Variant at chromosome position 77190708, chromosome 11, gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Rare_genetic_deafness', 'Usher_syndrome', 'Usher_syndrome_type_1', 'Usher_syndrome_type_1B']
CACTGTGCCTGGCACTGTGCTAGGTGTGTCATAAGCCTTGGCTCATTCATCTTCACAGCAATCTTGTAAGGATTCCTTTAAAATGAACACCAAAAAATTACCTTAATTGTTTTCATCCCATTACAAAAGTCATACATGGCCCCTTAAGTATTCACACATTACAGAAATATACCAGAGACAAAGTCCCTACTCATTCCATCCCCCAGTGACACCCCAGGATGCTTTTCCTGTTTCCGCTTTGTCCGTTGCCATGGGTAGAAGTTGCACCTGCTGCCGTGACTATGGGCTGGGATCAGAGAGGCGAACTCACCTGCCTGGGC...
CACTGTGCCTGGCACTGTGCTAGGTGTGTCATAAGCCTTGGCTCATTCATCTTCACAGCAATCTTGTAAGGATTCCTTTAAAATGAACACCAAAAAATTACCTTAATTGTTTTCATCCCATTACAAAAGTCATACATGGCCCCTTAAGTATTCACACATTACAGAAATATACCAGAGACAAAGTCCCTACTCATTCCATCCCCCAGTGACACCCCAGGATGCTTTTCCTGTTTCCGCTTTGTCCGTTGCCATGGGTAGAAGTTGCACCTGCTGCCGTGACTATGGGCTGGGATCAGAGAGGCGAACTCACCTGCCTGGGC...
pathogenic
181,239
Determine if the mutation at chromosome 11, position 77190773 in gene MYO7A (myosin VIIA) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
GTAAGGATTCCTTTAAAATGAACACCAAAAAATTACCTTAATTGTTTTCATCCCATTACAAAAGTCATACATGGCCCCTTAAGTATTCACACATTACAGAAATATACCAGAGACAAAGTCCCTACTCATTCCATCCCCCAGTGACACCCCAGGATGCTTTTCCTGTTTCCGCTTTGTCCGTTGCCATGGGTAGAAGTTGCACCTGCTGCCGTGACTATGGGCTGGGATCAGAGAGGCGAACTCACCTGCCTGGGCCACCAGCTGGTTAGGAACGAGGCAGAGGCGGGGACTGTGCTTCTCATTAGCATGGTCACCTGTGG...
GTAAGGATTCCTTTAAAATGAACACCAAAAAATTACCTTAATTGTTTTCATCCCATTACAAAAGTCATACATGGCCCCTTAAGTATTCACACATTACAGAAATATACCAGAGACAAAGTCCCTACTCATTCCATCCCCCAGTGACACCCCAGGATGCTTTTCCTGTTTCCGCTTTGTCCGTTGCCATGGGTAGAAGTTGCACCTGCTGCCGTGACTATGGGCTGGGATCAGAGAGGCGAACTCACCTGCCTGGGCCACCAGCTGGTTAGGAACGAGGCAGAGGCGGGGACTGTGCTTCTCATTAGCATGGTCACCTGTGG...
pathogenic
181,240
Does the variant impacting MYO7A (myosin VIIA) on chromosome 11, position 77190817, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Usher_syndrome_type_1']
TTTTCATCCCATTACAAAAGTCATACATGGCCCCTTAAGTATTCACACATTACAGAAATATACCAGAGACAAAGTCCCTACTCATTCCATCCCCCAGTGACACCCCAGGATGCTTTTCCTGTTTCCGCTTTGTCCGTTGCCATGGGTAGAAGTTGCACCTGCTGCCGTGACTATGGGCTGGGATCAGAGAGGCGAACTCACCTGCCTGGGCCACCAGCTGGTTAGGAACGAGGCAGAGGCGGGGACTGTGCTTCTCATTAGCATGGTCACCTGTGGCTGTGGCTGCGGCTGCTGAGCCCAGAGCAGGATACGCACCACCC...
TTTTCATCCCATTACAAAAGTCATACATGGCCCCTTAAGTATTCACACATTACAGAAATATACCAGAGACAAAGTCCCTACTCATTCCATCCCCCAGTGACACCCCAGGATGCTTTTCCTGTTTCCGCTTTGTCCGTTGCCATGGGTAGAAGTTGCACCTGCTGCCGTGACTATGGGCTGGGATCAGAGAGGCGAACTCACCTGCCTGGGCCACCAGCTGGTTAGGAACGAGGCAGAGGCGGGGACTGTGCTTCTCATTAGCATGGTCACCTGTGGCTGTGGCTGCGGCTGCTGAGCCCAGAGCAGGATACGCACCACCC...
pathogenic
181,244
Benign or pathogenic: chromosome 11, position 77190879, gene MYO7A (myosin VIIA) variant? Disease(s) if pathogenic?
benign
CCAGAGACAAAGTCCCTACTCATTCCATCCCCCAGTGACACCCCAGGATGCTTTTCCTGTTTCCGCTTTGTCCGTTGCCATGGGTAGAAGTTGCACCTGCTGCCGTGACTATGGGCTGGGATCAGAGAGGCGAACTCACCTGCCTGGGCCACCAGCTGGTTAGGAACGAGGCAGAGGCGGGGACTGTGCTTCTCATTAGCATGGTCACCTGTGGCTGTGGCTGCGGCTGCTGAGCCCAGAGCAGGATACGCACCACCCTGGATGGTGGGGCCCTGGCTGTGGGAACTGGATTGGAGTTGGGGAGGTGCTTTATGCCCGAT...
CCAGAGACAAAGTCCCTACTCATTCCATCCCCCAGTGACACCCCAGGATGCTTTTCCTGTTTCCGCTTTGTCCGTTGCCATGGGTAGAAGTTGCACCTGCTGCCGTGACTATGGGCTGGGATCAGAGAGGCGAACTCACCTGCCTGGGCCACCAGCTGGTTAGGAACGAGGCAGAGGCGGGGACTGTGCTTCTCATTAGCATGGTCACCTGTGGCTGTGGCTGCGGCTGCTGAGCCCAGAGCAGGATACGCACCACCCTGGATGGTGGGGCCCTGGCTGTGGGAACTGGATTGGAGTTGGGGAGGTGCTTTATGCCCGAT...
benign
181,247
Is the variant located on chromosome 11 at position 77192149, gene MYO7A (myosin VIIA), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
GGGACACGGACACAGCCGCCCAGCTGGCTGGAGCTGCAGGTTCGTGCGTGTGTATGCACGTGCTCGTGTGCATGTGTGCGCACGTGTGTAAATGCGTGTGTGTGTGTGTCCAGTGCACTCGAGTGCCCCAGAAACATTCCCTGCTTTGAGATTCTGTGGTTCCTCAGACACCTACCCTCAAGTTCTGGAACCCCAGGCCCATCGGAACAGAAAAGCCCCCAAAGGATGAGGGACTCCATTTGCTGGCCTTACGGTCAAGACGACTTGGGCAAAGGAGATTCCCTCTGTGTCTCAATGCCTTTACCTGCCACATGGTGAAG...
GGGACACGGACACAGCCGCCCAGCTGGCTGGAGCTGCAGGTTCGTGCGTGTGTATGCACGTGCTCGTGTGCATGTGTGCGCACGTGTGTAAATGCGTGTGTGTGTGTGTCCAGTGCACTCGAGTGCCCCAGAAACATTCCCTGCTTTGAGATTCTGTGGTTCCTCAGACACCTACCCTCAAGTTCTGGAACCCCAGGCCCATCGGAACAGAAAAGCCCCCAAAGGATGAGGGACTCCATTTGCTGGCCTTACGGTCAAGACGACTTGGGCAAAGGAGATTCCCTCTGTGTCTCAATGCCTTTACCTGCCACATGGTGAAG...
pathogenic
181,261
Gene MYO7A (myosin VIIA) variant at chromosome 11, position 77192190—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Rare_genetic_deafness']
TCGTGCGTGTGTATGCACGTGCTCGTGTGCATGTGTGCGCACGTGTGTAAATGCGTGTGTGTGTGTGTCCAGTGCACTCGAGTGCCCCAGAAACATTCCCTGCTTTGAGATTCTGTGGTTCCTCAGACACCTACCCTCAAGTTCTGGAACCCCAGGCCCATCGGAACAGAAAAGCCCCCAAAGGATGAGGGACTCCATTTGCTGGCCTTACGGTCAAGACGACTTGGGCAAAGGAGATTCCCTCTGTGTCTCAATGCCTTTACCTGCCACATGGTGAAGGTTATATGAAGTGATAGCAGAGACCCCTGGCCTGTGGCAGT...
TCGTGCGTGTGTATGCACGTGCTCGTGTGCATGTGTGCGCACGTGTGTAAATGCGTGTGTGTGTGTGTCCAGTGCACTCGAGTGCCCCAGAAACATTCCCTGCTTTGAGATTCTGTGGTTCCTCAGACACCTACCCTCAAGTTCTGGAACCCCAGGCCCATCGGAACAGAAAAGCCCCCAAAGGATGAGGGACTCCATTTGCTGGCCTTACGGTCAAGACGACTTGGGCAAAGGAGATTCCCTCTGTGTCTCAATGCCTTTACCTGCCACATGGTGAAGGTTATATGAAGTGATAGCAGAGACCCCTGGCCTGTGGCAGT...
pathogenic
181,262
Is the genetic variant on chromosome 11, position 77192232, gene MYO7A (myosin VIIA), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
GTGTGTAAATGCGTGTGTGTGTGTGTCCAGTGCACTCGAGTGCCCCAGAAACATTCCCTGCTTTGAGATTCTGTGGTTCCTCAGACACCTACCCTCAAGTTCTGGAACCCCAGGCCCATCGGAACAGAAAAGCCCCCAAAGGATGAGGGACTCCATTTGCTGGCCTTACGGTCAAGACGACTTGGGCAAAGGAGATTCCCTCTGTGTCTCAATGCCTTTACCTGCCACATGGTGAAGGTTATATGAAGTGATAGCAGAGACCCCTGGCCTGTGGCAGTGCCTGACCTCTCAGCCCCAGGCCCTGGCTCAGGGGTCCTAAA...
GTGTGTAAATGCGTGTGTGTGTGTGTCCAGTGCACTCGAGTGCCCCAGAAACATTCCCTGCTTTGAGATTCTGTGGTTCCTCAGACACCTACCCTCAAGTTCTGGAACCCCAGGCCCATCGGAACAGAAAAGCCCCCAAAGGATGAGGGACTCCATTTGCTGGCCTTACGGTCAAGACGACTTGGGCAAAGGAGATTCCCTCTGTGTCTCAATGCCTTTACCTGCCACATGGTGAAGGTTATATGAAGTGATAGCAGAGACCCCTGGCCTGTGGCAGTGCCTGACCTCTCAGCCCCAGGCCCTGGCTCAGGGGTCCTAAA...
pathogenic
181,263
Is the genetic variant on chromosome 11, position 77194384, gene MYO7A (myosin VIIA), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome', 'Usher_syndrome_type_1']
CGTTTGGGCTGAGTGCTCCTCTGTGAGCCATCATTAGCTCAGGCTGGGGTGAGCCTGACTGCAACCAGGCACTCTTCAGGCTCCTGGATGGACACCGCCTACTTCAGGGGGCTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCTTCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATTCTGAGTATATCTAGTAAGCGCTGCATTAAATGAGAAATACAGCCATTCCTTGAGATCAGAATTTGCAAATGTG...
CGTTTGGGCTGAGTGCTCCTCTGTGAGCCATCATTAGCTCAGGCTGGGGTGAGCCTGACTGCAACCAGGCACTCTTCAGGCTCCTGGATGGACACCGCCTACTTCAGGGGGCTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCTTCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATTCTGAGTATATCTAGTAAGCGCTGCATTAAATGAGAAATACAGCCATTCCTTGAGATCAGAATTTGCAAATGTG...
pathogenic
181,270
Mutation found at chromosome 11 position 77194424, gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic
AGGCTGGGGTGAGCCTGACTGCAACCAGGCACTCTTCAGGCTCCTGGATGGACACCGCCTACTTCAGGGGGCTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCTTCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATTCTGAGTATATCTAGTAAGCGCTGCATTAAATGAGAAATACAGCCATTCCTTGAGATCAGAATTTGCAAATGTGTATTCTTTTTTCTCCTTCTGAGGACAGGAGTTATGTGGTT...
AGGCTGGGGTGAGCCTGACTGCAACCAGGCACTCTTCAGGCTCCTGGATGGACACCGCCTACTTCAGGGGGCTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCTTCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATTCTGAGTATATCTAGTAAGCGCTGCATTAAATGAGAAATACAGCCATTCCTTGAGATCAGAATTTGCAAATGTGTATTCTTTTTTCTCCTTCTGAGGACAGGAGTTATGTGGTT...
pathogenic
181,272
Classify the chromosome 11 variant at position 77194451 affecting gene MYO7A (myosin VIIA) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
GGCACTCTTCAGGCTCCTGGATGGACACCGCCTACTTCAGGGGGCTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCTTCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATTCTGAGTATATCTAGTAAGCGCTGCATTAAATGAGAAATACAGCCATTCCTTGAGATCAGAATTTGCAAATGTGTATTCTTTTTTCTCCTTCTGAGGACAGGAGTTATGTGGTTGTTTTGTTTTCGATAATGGTAATGGTA...
GGCACTCTTCAGGCTCCTGGATGGACACCGCCTACTTCAGGGGGCTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCTTCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATTCTGAGTATATCTAGTAAGCGCTGCATTAAATGAGAAATACAGCCATTCCTTGAGATCAGAATTTGCAAATGTGTATTCTTTTTTCTCCTTCTGAGGACAGGAGTTATGTGGTTGTTTTGTTTTCGATAATGGTAATGGTA...
pathogenic
181,274
Is the genetic change at chromosome 11, position 77194495, within gene MYO7A (myosin VIIA) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
CTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCTTCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATTCTGAGTATATCTAGTAAGCGCTGCATTAAATGAGAAATACAGCCATTCCTTGAGATCAGAATTTGCAAATGTGTATTCTTTTTTCTCCTTCTGAGGACAGGAGTTATGTGGTTGTTTTGTTTTCGATAATGGTAATGGTAGCTATGGTTCTGTTGGTGATTGTGATGGAGGGATGAGAAAGGAG...
CTCGTGAGGAGAGGCGAGATGGCGGGAGCAAGGGCTTCTGAGGATGTCCTGAATTCCACCAGTGGAGGAGGCCCCCACACTGCTGTAGTGACTGTGCGTGCTACAGAGGACGTGCCGCAGGACCTGCTGCACCATTCTGAGTATATCTAGTAAGCGCTGCATTAAATGAGAAATACAGCCATTCCTTGAGATCAGAATTTGCAAATGTGTATTCTTTTTTCTCCTTCTGAGGACAGGAGTTATGTGGTTGTTTTGTTTTCGATAATGGTAATGGTAGCTATGGTTCTGTTGGTGATTGTGATGGAGGGATGAGAAAGGAG...
pathogenic
181,279
Classify the chromosome 11 variant at position 77198552 affecting gene MYO7A (myosin VIIA) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
TTATTTTGAAATAATTTCAAAGTTATGGAGAAATTGCACGTTCAAAAAAGTAGGACTGCTATGTGCACTTCACTTCCCAGATTCACTGGGTGATAGCCACACTTGCTCAGTGATTTGTCTCTCTGCCTACATATGTATTTTCTCTGAGTCATTTGAGCTTGGGTTGGTGACATTGAGCTCTTTGCCTCTGAATTCTCACCGCTCTCAGGATGGCACCCCTCATGGGCTCTCATGGGTGGAGATGGGGCCGTCTGTGAGCTGGCATACACATCCACCCTTACCTATGCCTGTGTCTACATTCTATAAAAACCAGGATTTCA...
TTATTTTGAAATAATTTCAAAGTTATGGAGAAATTGCACGTTCAAAAAAGTAGGACTGCTATGTGCACTTCACTTCCCAGATTCACTGGGTGATAGCCACACTTGCTCAGTGATTTGTCTCTCTGCCTACATATGTATTTTCTCTGAGTCATTTGAGCTTGGGTTGGTGACATTGAGCTCTTTGCCTCTGAATTCTCACCGCTCTCAGGATGGCACCCCTCATGGGCTCTCATGGGTGGAGATGGGGCCGTCTGTGAGCTGGCATACACATCCACCCTTACCTATGCCTGTGTCTACATTCTATAAAAACCAGGATTTCA...
pathogenic
181,299
The chromosome 11, position 77198597 genetic variant in gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Rare_genetic_deafness', 'Usher_syndrome_type_1']
AAAAGTAGGACTGCTATGTGCACTTCACTTCCCAGATTCACTGGGTGATAGCCACACTTGCTCAGTGATTTGTCTCTCTGCCTACATATGTATTTTCTCTGAGTCATTTGAGCTTGGGTTGGTGACATTGAGCTCTTTGCCTCTGAATTCTCACCGCTCTCAGGATGGCACCCCTCATGGGCTCTCATGGGTGGAGATGGGGCCGTCTGTGAGCTGGCATACACATCCACCCTTACCTATGCCTGTGTCTACATTCTATAAAAACCAGGATTTCACTCTGACCCCTCCAATGCTACCCCAGAACCCCAGAGTTCTCACTA...
AAAAGTAGGACTGCTATGTGCACTTCACTTCCCAGATTCACTGGGTGATAGCCACACTTGCTCAGTGATTTGTCTCTCTGCCTACATATGTATTTTCTCTGAGTCATTTGAGCTTGGGTTGGTGACATTGAGCTCTTTGCCTCTGAATTCTCACCGCTCTCAGGATGGCACCCCTCATGGGCTCTCATGGGTGGAGATGGGGCCGTCTGTGAGCTGGCATACACATCCACCCTTACCTATGCCTGTGTCTACATTCTATAAAAACCAGGATTTCACTCTGACCCCTCCAATGCTACCCCAGAACCCCAGAGTTCTCACTA...
pathogenic
181,301
Considering the variant on chromosome 11, location 77198607, involving gene MYO7A (myosin VIIA), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Rare_genetic_deafness']
CTGCTATGTGCACTTCACTTCCCAGATTCACTGGGTGATAGCCACACTTGCTCAGTGATTTGTCTCTCTGCCTACATATGTATTTTCTCTGAGTCATTTGAGCTTGGGTTGGTGACATTGAGCTCTTTGCCTCTGAATTCTCACCGCTCTCAGGATGGCACCCCTCATGGGCTCTCATGGGTGGAGATGGGGCCGTCTGTGAGCTGGCATACACATCCACCCTTACCTATGCCTGTGTCTACATTCTATAAAAACCAGGATTTCACTCTGACCCCTCCAATGCTACCCCAGAACCCCAGAGTTCTCACTAGGGCTTGGGG...
CTGCTATGTGCACTTCACTTCCCAGATTCACTGGGTGATAGCCACACTTGCTCAGTGATTTGTCTCTCTGCCTACATATGTATTTTCTCTGAGTCATTTGAGCTTGGGTTGGTGACATTGAGCTCTTTGCCTCTGAATTCTCACCGCTCTCAGGATGGCACCCCTCATGGGCTCTCATGGGTGGAGATGGGGCCGTCTGTGAGCTGGCATACACATCCACCCTTACCTATGCCTGTGTCTACATTCTATAAAAACCAGGATTTCACTCTGACCCCTCCAATGCTACCCCAGAACCCCAGAGTTCTCACTAGGGCTTGGGG...
pathogenic
181,302
Mutation at chromosome 11, position 77199607, within MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'MYO7A-related_disorder', 'Usher_syndrome_type_1']
TTGCTCTTCTCCAGGTTTTATGAAGCCTACAAATTCTCAGGTACCCCGCAGCCTGCAATGCTCCCAGTCCCTTGCTCTGTAGCTCCAGCCCACAGCCTACAAATTCTCAGGTACCCCGCAGCCTGCAATGCTCCCAGTCCCTTGCTCTGTAGCTCCAGCCCACAGCCTACAAATTCTCAGGTACCCCACAGCCTGCAATGCTCCCAGTCCCTTGCTCTGTAGCTCCAGCCCACAGCAGGGGAGGGAAACGTCTTGAGCCAGGGGCCCCCGTCAGTGGACCTCTTGCCTGCGGGATGCTTGGTCTGCTCTGGTCAATGCTG...
TTGCTCTTCTCCAGGTTTTATGAAGCCTACAAATTCTCAGGTACCCCGCAGCCTGCAATGCTCCCAGTCCCTTGCTCTGTAGCTCCAGCCCACAGCCTACAAATTCTCAGGTACCCCGCAGCCTGCAATGCTCCCAGTCCCTTGCTCTGTAGCTCCAGCCCACAGCCTACAAATTCTCAGGTACCCCACAGCCTGCAATGCTCCCAGTCCCTTGCTCTGTAGCTCCAGCCCACAGCAGGGGAGGGAAACGTCTTGAGCCAGGGGCCCCCGTCAGTGGACCTCTTGCCTGCGGGATGCTTGGTCTGCTCTGGTCAATGCTG...
pathogenic
181,307
Assess the variant on chromosome 11, position 77199803, impacting MYO7A (myosin VIIA): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Hearing_loss,_autosomal_recessive', 'Retinal_dystrophy', 'Usher_syndrome', 'Usher_syndrome_type_1']
AATGCTCCCAGTCCCTTGCTCTGTAGCTCCAGCCCACAGCAGGGGAGGGAAACGTCTTGAGCCAGGGGCCCCCGTCAGTGGACCTCTTGCCTGCGGGATGCTTGGTCTGCTCTGGTCAATGCTGCTGAGTGGGTCCTGCCTCCCCAACACCCGGTAGCGACTCCATGGCACATCTTCTGTGCTCAGTGGTGCACGGGATTGAAAAACTGAGTGAGGATTGATTCATTAAGGCACATACTATGTATACAACAGGGTGGCCCAGGGTTCAGACAGGGCCAGCCCTGCTGGGCCGACTCTGTGAAGTCGAGAGTAGCAGATAA...
AATGCTCCCAGTCCCTTGCTCTGTAGCTCCAGCCCACAGCAGGGGAGGGAAACGTCTTGAGCCAGGGGCCCCCGTCAGTGGACCTCTTGCCTGCGGGATGCTTGGTCTGCTCTGGTCAATGCTGCTGAGTGGGTCCTGCCTCCCCAACACCCGGTAGCGACTCCATGGCACATCTTCTGTGCTCAGTGGTGCACGGGATTGAAAAACTGAGTGAGGATTGATTCATTAAGGCACATACTATGTATACAACAGGGTGGCCCAGGGTTCAGACAGGGCCAGCCCTGCTGGGCCGACTCTGTGAAGTCGAGAGTAGCAGATAA...
pathogenic
181,316
Determine whether the variant at chromosome 11, position 77201511, in gene MYO7A (myosin VIIA) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
ATGTGTCTGAGCTGGGCCACGTCTCCCACTGGTTGGGGCATGACTGACTCAACTGGCCTTGATCTCCTTCAGGGAGTGCCGTGTCTGGCTCTCACTGGGCTGCTCTGATCTTGGCTGTGCTGCGCCTCACTCAGGCTGGGCAGGACTGACCCCGGCGGGGCCCTGTTCTCCGTGTTGGTCCTGCAGGGGAGCGAAAACGACGGCCCCCAGCTTCACGCTGGCCACCATCAAGGGGGACGAATACACCTTCACCTCCAGCAATGCTGAGGACATTCGTGACCTGGTGGTCACCTTCCTAGAGGGGCTCCGGAAGAGATCTA...
ATGTGTCTGAGCTGGGCCACGTCTCCCACTGGTTGGGGCATGACTGACTCAACTGGCCTTGATCTCCTTCAGGGAGTGCCGTGTCTGGCTCTCACTGGGCTGCTCTGATCTTGGCTGTGCTGCGCCTCACTCAGGCTGGGCAGGACTGACCCCGGCGGGGCCCTGTTCTCCGTGTTGGTCCTGCAGGGGAGCGAAAACGACGGCCCCCAGCTTCACGCTGGCCACCATCAAGGGGGACGAATACACCTTCACCTCCAGCAATGCTGAGGACATTCGTGACCTGGTGGTCACCTTCCTAGAGGGGCTCCGGAAGAGATCTA...
pathogenic
181,321