question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Variant on chromosome 11, at position 77202397, affecting MYO7A (myosin VIIA): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome', 'Usher_syndrome_type_1']
CACTCATGGCAGAAGGAGAAGGGGTGCCTGCATCAGAAGGAAGGAAGAGAGCAGGGGGTGCCAGGCTCTTTTTAAACAATCAGTTCTCACAGAGACTATATAGAGTGAGAACTCACTCATTACCGTGAGCACGGCACCACACTGTTCATGAGGGACCCACTCCCATGACCCAAACACCTCACACTAGGCCACTGCCAACACTGGGAGATCAAGTTTCAACAGAGAGATTTGGAGGGGACAAATATCTAAACCATATCACAGACCATGCCCCGTGGCCTTGGCCTTGGCACTCAAGGCTGCTAGGATCTTGTTCCCATCTT...
CACTCATGGCAGAAGGAGAAGGGGTGCCTGCATCAGAAGGAAGGAAGAGAGCAGGGGGTGCCAGGCTCTTTTTAAACAATCAGTTCTCACAGAGACTATATAGAGTGAGAACTCACTCATTACCGTGAGCACGGCACCACACTGTTCATGAGGGACCCACTCCCATGACCCAAACACCTCACACTAGGCCACTGCCAACACTGGGAGATCAAGTTTCAACAGAGAGATTTGGAGGGGACAAATATCTAAACCATATCACAGACCATGCCCCGTGGCCTTGGCCTTGGCACTCAAGGCTGCTAGGATCTTGTTCCCATCTT...
pathogenic
181,334
A genetic variant on chromosome 11, position 77203097, affects the gene MYO7A (myosin VIIA). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Rare_genetic_deafness', 'Retinal_dystrophy', 'Usher_syndrome_type_1']
AGCCCGTGTGACCAGAGCACAGGGGGCAGAGAGCTAAGCGTGATGCCAGCACAGAGGCGGGAGAAAGCTGGCCTGTCCAGGGAACTGCGAACAGCTTGGTTTGGCTGGGAACAGGCACAGTGAGGGAGGAGAGGCGAGGTGGAAGGAGTCTGGGAGGCCCGCTCACAACAGGCCCAGGAGTGTGGGGCTTCCTCCCAAGGGCAATGAGGAGCCGTGGAAGGCTTTTGAGCAGGAGAGTAGCCCACTCTGGTGATGGTCTCTGTATGGAGAGTTGTGACAAGGTGGAGGCAGAGTGGCAAGTGGGCAGACATGAGTGATAA...
AGCCCGTGTGACCAGAGCACAGGGGGCAGAGAGCTAAGCGTGATGCCAGCACAGAGGCGGGAGAAAGCTGGCCTGTCCAGGGAACTGCGAACAGCTTGGTTTGGCTGGGAACAGGCACAGTGAGGGAGGAGAGGCGAGGTGGAAGGAGTCTGGGAGGCCCGCTCACAACAGGCCCAGGAGTGTGGGGCTTCCTCCCAAGGGCAATGAGGAGCCGTGGAAGGCTTTTGAGCAGGAGAGTAGCCCACTCTGGTGATGGTCTCTGTATGGAGAGTTGTGACAAGGTGGAGGCAGAGTGGCAAGTGGGCAGACATGAGTGATAA...
pathogenic
181,339
The mutation in gene MYO7A (myosin VIIA) at chromosome 11, position 77203149—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
AGAGGCGGGAGAAAGCTGGCCTGTCCAGGGAACTGCGAACAGCTTGGTTTGGCTGGGAACAGGCACAGTGAGGGAGGAGAGGCGAGGTGGAAGGAGTCTGGGAGGCCCGCTCACAACAGGCCCAGGAGTGTGGGGCTTCCTCCCAAGGGCAATGAGGAGCCGTGGAAGGCTTTTGAGCAGGAGAGTAGCCCACTCTGGTGATGGTCTCTGTATGGAGAGTTGTGACAAGGTGGAGGCAGAGTGGCAAGTGGGCAGACATGAGTGATAACACCTCAGTTCTTCTGTGGGAAGATGTTCCAACTCAGCCTGTCTCTGCCCCC...
AGAGGCGGGAGAAAGCTGGCCTGTCCAGGGAACTGCGAACAGCTTGGTTTGGCTGGGAACAGGCACAGTGAGGGAGGAGAGGCGAGGTGGAAGGAGTCTGGGAGGCCCGCTCACAACAGGCCCAGGAGTGTGGGGCTTCCTCCCAAGGGCAATGAGGAGCCGTGGAAGGCTTTTGAGCAGGAGAGTAGCCCACTCTGGTGATGGTCTCTGTATGGAGAGTTGTGACAAGGTGGAGGCAGAGTGGCAAGTGGGCAGACATGAGTGATAACACCTCAGTTCTTCTGTGGGAAGATGTTCCAACTCAGCCTGTCTCTGCCCCC...
pathogenic
181,342
For chromosome 11, position 77204167, gene MYO7A (myosin VIIA): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic
AGGAGGCAGCAGGGACCTCAGAGACCCCAAGGAGGAACGGGGCTCCCAGGGTCAGAATGGGGCATGGGGTCCATACCCCTGAAGAGTCTCCCAGAGTCCAGAAGGCTTCAGGGTATACCATGTTGATCCTGGTGGCCACAGGTAGAGAGCTGACCTGAGCCCCCTGTCTCTTGGTCCCTAGGCCCTGGTCACCATGACTCCCGATCAGAGGCAGGACGTTGTCCGGCTCTTGCAGCTGCGAACGGCGGAGCCCGAGGTGCGTGCCAAGCCCTACACGCTGGAGGAGTTTTCCTATGACTACTTCAGGTGATGCCTCCTGG...
AGGAGGCAGCAGGGACCTCAGAGACCCCAAGGAGGAACGGGGCTCCCAGGGTCAGAATGGGGCATGGGGTCCATACCCCTGAAGAGTCTCCCAGAGTCCAGAAGGCTTCAGGGTATACCATGTTGATCCTGGTGGCCACAGGTAGAGAGCTGACCTGAGCCCCCTGTCTCTTGGTCCCTAGGCCCTGGTCACCATGACTCCCGATCAGAGGCAGGACGTTGTCCGGCTCTTGCAGCTGCGAACGGCGGAGCCCGAGGTGCGTGCCAAGCCCTACACGCTGGAGGAGTTTTCCTATGACTACTTCAGGTGATGCCTCCTGG...
pathogenic
181,353
A genetic alteration at chromosome 11, position 77205468, in gene MYO7A (myosin VIIA)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'MYO7A-related_disorder', 'Usher_syndrome_type_1']
TGGATTTGGTGCCTTGTGCTGGGCCAGGCATGCAGGTAGAGCAGGGACCAGCCCAGCCCCTGGCCTCATGGGACCATACACACATCCAGATCAATGTTGAGATGGGACCCGGCAGCACTGTGACCTGACCCATGTGACCTGGAGGGGGCAGAGAGGACTTCCTGGAGGAAGTGGTATCTAGGCTGAGCCCTGAAGGCTAAGTACGACTTAGCCAGGCAAAGGGGAGGGAGGGGGAGTGTTCCAGAGAGAGGGAGCAGCAGCAAGGCCCCGAGGCACACAGAGCAGGGCTGTTCCAGGGCTCCGGGGCTTCAGCACAGACA...
TGGATTTGGTGCCTTGTGCTGGGCCAGGCATGCAGGTAGAGCAGGGACCAGCCCAGCCCCTGGCCTCATGGGACCATACACACATCCAGATCAATGTTGAGATGGGACCCGGCAGCACTGTGACCTGACCCATGTGACCTGGAGGGGGCAGAGAGGACTTCCTGGAGGAAGTGGTATCTAGGCTGAGCCCTGAAGGCTAAGTACGACTTAGCCAGGCAAAGGGGAGGGAGGGGGAGTGTTCCAGAGAGAGGGAGCAGCAGCAAGGCCCCGAGGCACACAGAGCAGGGCTGTTCCAGGGCTCCGGGGCTTCAGCACAGACA...
pathogenic
181,363
Clinical significance of chromosome 11, position 77205522, gene MYO7A (myosin VIIA): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
AGCCCCTGGCCTCATGGGACCATACACACATCCAGATCAATGTTGAGATGGGACCCGGCAGCACTGTGACCTGACCCATGTGACCTGGAGGGGGCAGAGAGGACTTCCTGGAGGAAGTGGTATCTAGGCTGAGCCCTGAAGGCTAAGTACGACTTAGCCAGGCAAAGGGGAGGGAGGGGGAGTGTTCCAGAGAGAGGGAGCAGCAGCAAGGCCCCGAGGCACACAGAGCAGGGCTGTTCCAGGGCTCCGGGGCTTCAGCACAGACAGGATGGGAAGACTGGGCTTAGGCAGGGTTCCCAAGCCCTGTGAGGAAGCTTGGG...
AGCCCCTGGCCTCATGGGACCATACACACATCCAGATCAATGTTGAGATGGGACCCGGCAGCACTGTGACCTGACCCATGTGACCTGGAGGGGGCAGAGAGGACTTCCTGGAGGAAGTGGTATCTAGGCTGAGCCCTGAAGGCTAAGTACGACTTAGCCAGGCAAAGGGGAGGGAGGGGGAGTGTTCCAGAGAGAGGGAGCAGCAGCAAGGCCCCGAGGCACACAGAGCAGGGCTGTTCCAGGGCTCCGGGGCTTCAGCACAGACAGGATGGGAAGACTGGGCTTAGGCAGGGTTCCCAAGCCCTGTGAGGAAGCTTGGG...
pathogenic
181,367
Is the genetic mutation found on chromosome 11 at position 77205610, within the gene MYO7A (myosin VIIA), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
AGGGGGCAGAGAGGACTTCCTGGAGGAAGTGGTATCTAGGCTGAGCCCTGAAGGCTAAGTACGACTTAGCCAGGCAAAGGGGAGGGAGGGGGAGTGTTCCAGAGAGAGGGAGCAGCAGCAAGGCCCCGAGGCACACAGAGCAGGGCTGTTCCAGGGCTCCGGGGCTTCAGCACAGACAGGATGGGAAGACTGGGCTTAGGCAGGGTTCCCAAGCCCTGTGAGGAAGCTTGGGCCGTGTCCTAAGGCCAGGGTGAACCACTGGGCAGGGGGTGGCATGGTCAGATTCACCATCTGGGAAGTCCATCCCAGCTGCTGTGAGG...
AGGGGGCAGAGAGGACTTCCTGGAGGAAGTGGTATCTAGGCTGAGCCCTGAAGGCTAAGTACGACTTAGCCAGGCAAAGGGGAGGGAGGGGGAGTGTTCCAGAGAGAGGGAGCAGCAGCAAGGCCCCGAGGCACACAGAGCAGGGCTGTTCCAGGGCTCCGGGGCTTCAGCACAGACAGGATGGGAAGACTGGGCTTAGGCAGGGTTCCCAAGCCCTGTGAGGAAGCTTGGGCCGTGTCCTAAGGCCAGGGTGAACCACTGGGCAGGGGGTGGCATGGTCAGATTCACCATCTGGGAAGTCCATCCCAGCTGCTGTGAGG...
pathogenic
181,375
Clinically, how would you classify the variant at chromosome 11, position 77207381, gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic
AAGGTCAGGAGGGACGGTGCTGCTGTGATGAGCAGCTGAGGGGTACATGGCCCCCTCACCCGGGGGTGCACAGGTCCTGTGACTCCCGATGGCAGCTGCCCCTGCTGGAGCCCACGCCTCCTCCTGCAGGTACAGCGAGGAGCGGGGTTGGGAGCTGCTCTGGCTGTGCACGGGCCTTTTCCCACCCAGCAACATCCTCCTGCCCCACGTGCAGCGCTTCCTGCAGTCCCGAAAGCACTGCCCACTCGCCATCGACTGCCTGCAACGGCTCCAGAAAGCCCTGAGGTACAGCGGCCACCAGGGGCAGGGACAGACACTGG...
AAGGTCAGGAGGGACGGTGCTGCTGTGATGAGCAGCTGAGGGGTACATGGCCCCCTCACCCGGGGGTGCACAGGTCCTGTGACTCCCGATGGCAGCTGCCCCTGCTGGAGCCCACGCCTCCTCCTGCAGGTACAGCGAGGAGCGGGGTTGGGAGCTGCTCTGGCTGTGCACGGGCCTTTTCCCACCCAGCAACATCCTCCTGCCCCACGTGCAGCGCTTCCTGCAGTCCCGAAAGCACTGCCCACTCGCCATCGACTGCCTGCAACGGCTCCAGAAAGCCCTGAGGTACAGCGGCCACCAGGGGCAGGGACAGACACTGG...
pathogenic
181,395
Clinical impact (benign or pathogenic) of the variant at chromosome 11, location 77208452, gene MYO7A (myosin VIIA): what disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Rare_genetic_deafness', 'Usher_syndrome_type_1', 'Usher_syndrome_type_1B']
CTTCCTGGAGCAGCTTCCTTCAGAAGGGCGCCCCTCCCTCCCTGTCTCTGAGGAGGACTTGCCTTGGAGAAAAGCGCTTCTCCCTCTGAGCTGGCTTTGCACTGGCTTTGCACCTCCCTGATGTAGGGCCCCACTGGCCCCCAGGTCCAGACCTCCCCTGTCGACTGAGCCCACTTTCCTGCAGGCAGAACCTCAACACCCCTTCCTCCCTCTCCACCTGAGGTGGTTGAGGTTCCCTCCATCCAGGTCCTGTCTGCCAAAGGTCCTGTCTGTCATGCCTGTAGTCACGCTGCCCCTCATGGTCCCCAGCCCCTGCCTGT...
CTTCCTGGAGCAGCTTCCTTCAGAAGGGCGCCCCTCCCTCCCTGTCTCTGAGGAGGACTTGCCTTGGAGAAAAGCGCTTCTCCCTCTGAGCTGGCTTTGCACTGGCTTTGCACCTCCCTGATGTAGGGCCCCACTGGCCCCCAGGTCCAGACCTCCCCTGTCGACTGAGCCCACTTTCCTGCAGGCAGAACCTCAACACCCCTTCCTCCCTCTCCACCTGAGGTGGTTGAGGTTCCCTCCATCCAGGTCCTGTCTGCCAAAGGTCCTGTCTGTCATGCCTGTAGTCACGCTGCCCCTCATGGTCCCCAGCCCCTGCCTGT...
pathogenic
181,403
Is the variant located on chromosome 11 at position 77208456, gene MYO7A (myosin VIIA), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
CTGGAGCAGCTTCCTTCAGAAGGGCGCCCCTCCCTCCCTGTCTCTGAGGAGGACTTGCCTTGGAGAAAAGCGCTTCTCCCTCTGAGCTGGCTTTGCACTGGCTTTGCACCTCCCTGATGTAGGGCCCCACTGGCCCCCAGGTCCAGACCTCCCCTGTCGACTGAGCCCACTTTCCTGCAGGCAGAACCTCAACACCCCTTCCTCCCTCTCCACCTGAGGTGGTTGAGGTTCCCTCCATCCAGGTCCTGTCTGCCAAAGGTCCTGTCTGTCATGCCTGTAGTCACGCTGCCCCTCATGGTCCCCAGCCCCTGCCTGTCTCA...
CTGGAGCAGCTTCCTTCAGAAGGGCGCCCCTCCCTCCCTGTCTCTGAGGAGGACTTGCCTTGGAGAAAAGCGCTTCTCCCTCTGAGCTGGCTTTGCACTGGCTTTGCACCTCCCTGATGTAGGGCCCCACTGGCCCCCAGGTCCAGACCTCCCCTGTCGACTGAGCCCACTTTCCTGCAGGCAGAACCTCAACACCCCTTCCTCCCTCTCCACCTGAGGTGGTTGAGGTTCCCTCCATCCAGGTCCTGTCTGCCAAAGGTCCTGTCTGTCATGCCTGTAGTCACGCTGCCCCTCATGGTCCCCAGCCCCTGCCTGTCTCA...
pathogenic
181,404
Mutation at chromosome 11, position 77208775, within MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Rare_genetic_deafness', 'Retinal_dystrophy', 'Usher_syndrome_type_1', 'Usher_syndrome_type_1B']
AACACAGTGTCTCATTCAGATAAGCTTTTCATTTGAAGAGTCATTTATGAAACTTGTCTGAGGCTGGAGACTCAGAAATGCCATAACAGGATTTCATTTGCAAGGACCAAAGACTTCCTCAAATCCTTTCCTGTCCCTCCAGACATCTCTCCTGCCATTAAACTTCCCCAGACGCTCAAACCCTCCCATCTGTCCGGGCTGCTTTCCCCTCCGCTTTTGGGTTTGCTTTTCCTCTACCTCAAGTCTCCTCCTTCTAATCACCCTTCCAGTCATCCTGCTGTGCTCCCTGGACCCCTCACTGTCACTCAGGCTTGTACACC...
AACACAGTGTCTCATTCAGATAAGCTTTTCATTTGAAGAGTCATTTATGAAACTTGTCTGAGGCTGGAGACTCAGAAATGCCATAACAGGATTTCATTTGCAAGGACCAAAGACTTCCTCAAATCCTTTCCTGTCCCTCCAGACATCTCTCCTGCCATTAAACTTCCCCAGACGCTCAAACCCTCCCATCTGTCCGGGCTGCTTTCCCCTCCGCTTTTGGGTTTGCTTTTCCTCTACCTCAAGTCTCCTCCTTCTAATCACCCTTCCAGTCATCCTGCTGTGCTCCCTGGACCCCTCACTGTCACTCAGGCTTGTACACC...
pathogenic
181,415
Gene MYO7A (myosin VIIA) variant at chromosome position 77211188 on chromosome 11: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic
GCATAGGCACCTGCAGGAAGCCGGGAGGGAAGCTTGCATGTTGAGCCTCTATTATGTGTCTGGCACTCTTCTCTCATTCTGTCCTCCCAACTAACCCCAAGAAGCAGGCATGTTGTCCCCATTTGACAGAGGGACAAAGAGACTCAGGCCGCGTGCTGTGATTAGGATCACACAGCTGATGGAACTGGGGTTTGATTCCAGGTCTTCATGACTGCAGGTTGGTGCTCTTTTCTGGGCTCAGCCTGCTTACCATTCTGTGGGAGAAAAACCATGATGCTGGGAAGGGCAGAGGAGGCAGGGACGGTGGCTGCTGTGGCAGA...
GCATAGGCACCTGCAGGAAGCCGGGAGGGAAGCTTGCATGTTGAGCCTCTATTATGTGTCTGGCACTCTTCTCTCATTCTGTCCTCCCAACTAACCCCAAGAAGCAGGCATGTTGTCCCCATTTGACAGAGGGACAAAGAGACTCAGGCCGCGTGCTGTGATTAGGATCACACAGCTGATGGAACTGGGGTTTGATTCCAGGTCTTCATGACTGCAGGTTGGTGCTCTTTTCTGGGCTCAGCCTGCTTACCATTCTGTGGGAGAAAAACCATGATGCTGGGAAGGGCAGAGGAGGCAGGGACGGTGGCTGCTGTGGCAGA...
pathogenic
181,433
Regarding the variant at chromosome 11 and position 77211325, affecting gene MYO7A (myosin VIIA): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_dominant_nonsyndromic_hearing_loss_11', 'Autosomal_recessive_nonsyndromic_hearing_loss_2', 'Usher_syndrome_type_1']
AGAGACTCAGGCCGCGTGCTGTGATTAGGATCACACAGCTGATGGAACTGGGGTTTGATTCCAGGTCTTCATGACTGCAGGTTGGTGCTCTTTTCTGGGCTCAGCCTGCTTACCATTCTGTGGGAGAAAAACCATGATGCTGGGAAGGGCAGAGGAGGCAGGGACGGTGGCTGCTGTGGCAGAGAGGACACTGGCCTGGGAGTGAGAAGGACTGCCCTCATCCAAACCTGGGATCTACCTTTCCTCATGCCCCTCCCCACCCACCCCATGCTGCCCACTGAGTGCATGGCCCCTGGACTACCAGTTCCCCCAGAGTCAGC...
AGAGACTCAGGCCGCGTGCTGTGATTAGGATCACACAGCTGATGGAACTGGGGTTTGATTCCAGGTCTTCATGACTGCAGGTTGGTGCTCTTTTCTGGGCTCAGCCTGCTTACCATTCTGTGGGAGAAAAACCATGATGCTGGGAAGGGCAGAGGAGGCAGGGACGGTGGCTGCTGTGGCAGAGAGGACACTGGCCTGGGAGTGAGAAGGACTGCCCTCATCCAAACCTGGGATCTACCTTTCCTCATGCCCCTCCCCACCCACCCCATGCTGCCCACTGAGTGCATGGCCCCTGGACTACCAGTTCCCCCAGAGTCAGC...
pathogenic
181,439
Clinical impact (benign or pathogenic) of the variant at chromosome 11, location 77211329, gene MYO7A (myosin VIIA): what disease(s) if pathogenic?
pathogenic; ['Rare_genetic_deafness', 'Usher_syndrome_type_1']
ACTCAGGCCGCGTGCTGTGATTAGGATCACACAGCTGATGGAACTGGGGTTTGATTCCAGGTCTTCATGACTGCAGGTTGGTGCTCTTTTCTGGGCTCAGCCTGCTTACCATTCTGTGGGAGAAAAACCATGATGCTGGGAAGGGCAGAGGAGGCAGGGACGGTGGCTGCTGTGGCAGAGAGGACACTGGCCTGGGAGTGAGAAGGACTGCCCTCATCCAAACCTGGGATCTACCTTTCCTCATGCCCCTCCCCACCCACCCCATGCTGCCCACTGAGTGCATGGCCCCTGGACTACCAGTTCCCCCAGAGTCAGCCTTG...
ACTCAGGCCGCGTGCTGTGATTAGGATCACACAGCTGATGGAACTGGGGTTTGATTCCAGGTCTTCATGACTGCAGGTTGGTGCTCTTTTCTGGGCTCAGCCTGCTTACCATTCTGTGGGAGAAAAACCATGATGCTGGGAAGGGCAGAGGAGGCAGGGACGGTGGCTGCTGTGGCAGAGAGGACACTGGCCTGGGAGTGAGAAGGACTGCCCTCATCCAAACCTGGGATCTACCTTTCCTCATGCCCCTCCCCACCCACCCCATGCTGCCCACTGAGTGCATGGCCCCTGGACTACCAGTTCCCCCAGAGTCAGCCTTG...
pathogenic
181,440
Assess the variant on chromosome 11, position 77212971, impacting MYO7A (myosin VIIA): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Hearing_loss,_autosomal_recessive', 'Usher_syndrome_type_1']
GGCCATGCACTCCAACTGCCAACTGCTGAGTCTGTGCAGGCAGACTTGCTCTGTCCCTGTCCTGTGCCGTATCCCCTGGGGGAGCAGTGTCAGCTGAGGCTGGAGAGGTGGGTGGGCCCATGTGCGGGGTAAGGTGGTAGACCCCGGCGTTGGGGGTCTTGGTGTGGTGGGAAAGGAGCCCACTTCTGCCAGGTCCCTGCACGCCTGTGACCTGCTCTGTCTCTGACAGGAGTTGCCCAAGTATCTCCGAGGCTACCACAAGTGCACGCGGGAGGAGGTGCTGCAGCTGGGGGCGCTGATCTACAGGGTCAAGTTCGAGG...
GGCCATGCACTCCAACTGCCAACTGCTGAGTCTGTGCAGGCAGACTTGCTCTGTCCCTGTCCTGTGCCGTATCCCCTGGGGGAGCAGTGTCAGCTGAGGCTGGAGAGGTGGGTGGGCCCATGTGCGGGGTAAGGTGGTAGACCCCGGCGTTGGGGGTCTTGGTGTGGTGGGAAAGGAGCCCACTTCTGCCAGGTCCCTGCACGCCTGTGACCTGCTCTGTCTCTGACAGGAGTTGCCCAAGTATCTCCGAGGCTACCACAAGTGCACGCGGGAGGAGGTGCTGCAGCTGGGGGCGCTGATCTACAGGGTCAAGTTCGAGG...
pathogenic
181,459
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 11, position 77214658, gene MYO7A (myosin VIIA). What disease(s) is it linked to if pathogenic?
benign
ACAGCTAGGATGGGAGGCCTTTTGAGGAGCTTGGCTGTGCGAGGAGAACAGGTAGGTAGCTGGAGGCAGGTGCAGGGTCCAGGAGGCTTTTTAAAGATGGGAGGCCCTTGGGCTGAGAGGGAGGACAAAGCAGAGGATGGCCTGGGGGACCCAGGAAGGGATGTGGGGCAGCACTGAGGGCCCAGCGGAGGTGGAAGCCATAGGTCATGGCAGGGCCGTCAGTACCACATAGGCAACAGGAGAGGCTGACTTTATCCCAGCTGGGGCCAGGCTTCATTCCTGTCCCCAAATGCTTTTCTTGCTCTGGGCCCCCATCTGAT...
ACAGCTAGGATGGGAGGCCTTTTGAGGAGCTTGGCTGTGCGAGGAGAACAGGTAGGTAGCTGGAGGCAGGTGCAGGGTCCAGGAGGCTTTTTAAAGATGGGAGGCCCTTGGGCTGAGAGGGAGGACAAAGCAGAGGATGGCCTGGGGGACCCAGGAAGGGATGTGGGGCAGCACTGAGGGCCCAGCGGAGGTGGAAGCCATAGGTCATGGCAGGGCCGTCAGTACCACATAGGCAACAGGAGAGGCTGACTTTATCCCAGCTGGGGCCAGGCTTCATTCCTGTCCCCAAATGCTTTTCTTGCTCTGGGCCCCCATCTGAT...
benign
181,482
A genetic variant on chromosome 11, position 78106927, affects the gene ALG8 (ALG8 alpha-1,3-glucosyltransferase). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['ALG8_congenital_disorder_of_glycosylation', 'Polycystic_liver_disease_3_with_or_without_kidney_cysts']
GCTTGAACCTGGGAGGCAGAGGATGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAGAATCTTGCTTCCCTGAGTAATTGCCTTCTCCAAAGACAGGAATGTTGTGGGATTGGGAGCTGCCTAGTGGTGGCAGTCAGGGAAACAGGACTTGGAGTTTCATTTCCAACCCTATAGCTCATCTCTTGGACAATGCCCTTCACCTGCTGGTGTTTGGTGTGAATTCAGACTAAAGACATTAAAAGTTTTTGCTTTACTTTTTAATTTGGAAACTCCAA...
GCTTGAACCTGGGAGGCAGAGGATGCAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCTGGGCAACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAAAAAGAATCTTGCTTCCCTGAGTAATTGCCTTCTCCAAAGACAGGAATGTTGTGGGATTGGGAGCTGCCTAGTGGTGGCAGTCAGGGAAACAGGACTTGGAGTTTCATTTCCAACCCTATAGCTCATCTCTTGGACAATGCCCTTCACCTGCTGGTGTTTGGTGTGAATTCAGACTAAAGACATTAAAAGTTTTTGCTTTACTTTTTAATTTGGAAACTCCAA...
pathogenic
181,509
Regarding the variant at chromosome 11 and position 78109498, affecting gene ALG8 (ALG8 alpha-1,3-glucosyltransferase): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['ALG8-related_disorder', 'ALG8_congenital_disorder_of_glycosylation', 'Autosomal_dominant_polycystic_liver_disease', 'Polycystic_liver_disease_3_with_or_without_kidney_cysts']
ACCTCGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTTTGAGCCACCGCACCTAGCCTTGATGTATATATTTAACTCATTAAAATTAATTCTACTGGCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTTAGGAGTTCAAGAACAGCCTGACCAACATAGTGAAACCCCATCTCTACTAAAAATACAAAAAAAACTAGCTGGGCGTGGTGGTACATACCTGTATTCCCAGGTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGG...
ACCTCGTGATCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTTTGAGCCACCGCACCTAGCCTTGATGTATATATTTAACTCATTAAAATTAATTCTACTGGCTGGGCATGGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTTAGGAGTTCAAGAACAGCCTGACCAACATAGTGAAACCCCATCTCTACTAAAAATACAAAAAAAACTAGCTGGGCGTGGTGGTACATACCTGTATTCCCAGGTACTCTGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGG...
pathogenic
181,511
Located at chromosome 11 position 78112723, the variant affecting gene ALG8 (ALG8 alpha-1,3-glucosyltransferase)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['ALG8_congenital_disorder_of_glycosylation', 'Polycystic_liver_disease_3_with_or_without_kidney_cysts']
CCCCAACAAGCTCTGGCTAATAGGACAGTCAGAGACAGTTTGAGCACCTATAGGGCCTGTCAAATGCCAGTGAAAATGAATACAATGTGGGAAAGATGTACCAAAATATTTTCTACTTACTAACCTCTTCCCCTTTCCCCTTTGGCCTGCTGATTCTCTCTTACAGCTAATAACTATCTCCCTAAAACAAAGTTGTCTAACTCTGACACTGACTTTCCATGTAAAACATCTTCAAAGACACAAACATACAAGTGAGGGTACAGTACAGCTTCCTGACTCAGACAAGGCAACTGGCCCTTGTACCTCATACTATGCTGGCT...
CCCCAACAAGCTCTGGCTAATAGGACAGTCAGAGACAGTTTGAGCACCTATAGGGCCTGTCAAATGCCAGTGAAAATGAATACAATGTGGGAAAGATGTACCAAAATATTTTCTACTTACTAACCTCTTCCCCTTTCCCCTTTGGCCTGCTGATTCTCTCTTACAGCTAATAACTATCTCCCTAAAACAAAGTTGTCTAACTCTGACACTGACTTTCCATGTAAAACATCTTCAAAGACACAAACATACAAGTGAGGGTACAGTACAGCTTCCTGACTCAGACAAGGCAACTGGCCCTTGTACCTCATACTATGCTGGCT...
pathogenic
181,518
Evaluate the clinical significance of the mutation at chromosome 11, position 78112745 in gene ALG8 (ALG8 alpha-1,3-glucosyltransferase): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['ALG8_congenital_disorder_of_glycosylation', 'Polycystic_liver_disease_3_with_or_without_kidney_cysts']
GGACAGTCAGAGACAGTTTGAGCACCTATAGGGCCTGTCAAATGCCAGTGAAAATGAATACAATGTGGGAAAGATGTACCAAAATATTTTCTACTTACTAACCTCTTCCCCTTTCCCCTTTGGCCTGCTGATTCTCTCTTACAGCTAATAACTATCTCCCTAAAACAAAGTTGTCTAACTCTGACACTGACTTTCCATGTAAAACATCTTCAAAGACACAAACATACAAGTGAGGGTACAGTACAGCTTCCTGACTCAGACAAGGCAACTGGCCCTTGTACCTCATACTATGCTGGCTGTTTAAAGCTTTTTTTGAAATA...
GGACAGTCAGAGACAGTTTGAGCACCTATAGGGCCTGTCAAATGCCAGTGAAAATGAATACAATGTGGGAAAGATGTACCAAAATATTTTCTACTTACTAACCTCTTCCCCTTTCCCCTTTGGCCTGCTGATTCTCTCTTACAGCTAATAACTATCTCCCTAAAACAAAGTTGTCTAACTCTGACACTGACTTTCCATGTAAAACATCTTCAAAGACACAAACATACAAGTGAGGGTACAGTACAGCTTCCTGACTCAGACAAGGCAACTGGCCCTTGTACCTCATACTATGCTGGCTGTTTAAAGCTTTTTTTGAAATA...
pathogenic
181,520
A genetic alteration at chromosome 11, position 78113901, in gene ALG8 (ALG8 alpha-1,3-glucosyltransferase)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['ALG8_congenital_disorder_of_glycosylation', 'Polycystic_liver_disease_3_with_or_without_kidney_cysts']
TAAAAACCATAGCCTGGGTTTTTCATTTCTTCTCACCTCATGTTAAAATGCAGGGTTATTTTCCTTACTGGTTTAATACCGAGAGTCACAACTTACATATTCTTCTTTCTTGTATGTTTAGGTTTAAAAGTGGGGTAGGCCAGGCATGGTGGCTTGTGCTGGTAATCCCAGCACTTTGGGAAGCCAAGGTGGGAGGATCATTTGAGACCAGAAGTTTGATCCCACTCTGGGCAACATAGTGAGACCCTCATCTCTAAAAAACAAAAATTTAAAAATCAGCCAGGTGTGGTGGTATGCACCTGTGGTCCCAGCAACTCAGG...
TAAAAACCATAGCCTGGGTTTTTCATTTCTTCTCACCTCATGTTAAAATGCAGGGTTATTTTCCTTACTGGTTTAATACCGAGAGTCACAACTTACATATTCTTCTTTCTTGTATGTTTAGGTTTAAAAGTGGGGTAGGCCAGGCATGGTGGCTTGTGCTGGTAATCCCAGCACTTTGGGAAGCCAAGGTGGGAGGATCATTTGAGACCAGAAGTTTGATCCCACTCTGGGCAACATAGTGAGACCCTCATCTCTAAAAAACAAAAATTTAAAAATCAGCCAGGTGTGGTGGTATGCACCTGTGGTCCCAGCAACTCAGG...
pathogenic
181,522
Clinical impact (benign or pathogenic) of the variant at chromosome 11, location 78124079, gene ALG8 (ALG8 alpha-1,3-glucosyltransferase): what disease(s) if pathogenic?
pathogenic; ['ALG8_congenital_disorder_of_glycosylation', 'Inborn_genetic_diseases', 'Polycystic_liver_disease_3_with_or_without_kidney_cysts']
GGAGTATGACTCATTTTTACTTTGCATGTGTGTGTGCTTTTCCAAAGTTTTTACAATGGGGATGTATTATTCTATAAAAAGACGATATTGAAAATGTGCTACATTTGAAGAGTGGCAAATTTTAACAATAAATCTAAAACAAATAATAGATGCAATTAAAGGGGGACTAGCAAAGGTATCCTCCTTTCGCCCTATGGAGCCTCAGTTCCCTCATGAATAGAGGCAGTAAACTTACAGGGTCACTGAGAAAATTAAATAAGTTAATAATCTGTATATCATGCTTGGTTCTGGGAACTGACACAGAGATTTCAATTTTTTTT...
GGAGTATGACTCATTTTTACTTTGCATGTGTGTGTGCTTTTCCAAAGTTTTTACAATGGGGATGTATTATTCTATAAAAAGACGATATTGAAAATGTGCTACATTTGAAGAGTGGCAAATTTTAACAATAAATCTAAAACAAATAATAGATGCAATTAAAGGGGGACTAGCAAAGGTATCCTCCTTTCGCCCTATGGAGCCTCAGTTCCCTCATGAATAGAGGCAGTAAACTTACAGGGTCACTGAGAAAATTAAATAAGTTAATAATCTGTATATCATGCTTGGTTCTGGGAACTGACACAGAGATTTCAATTTTTTTT...
pathogenic
181,539
Gene ALG8 (ALG8 alpha-1,3-glucosyltransferase) variant at chromosome position 78127327 on chromosome 11: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
benign
ACTTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTAAGTCTCACTTTTTGCACCTATACAACAGGGATAGTAGTATCTACCTCATGGGTTATGGTATTCCATTTTATATATACATATAAAATACTATATATGGTATCGAAACTCATAGGAAACTTGCAAAAAATTTGCCTTAAAAAAAACTCCCTGGGCCGGGCATAGTGGCTCACACCTGTAATCCCAGCACTTTGGAAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAAACCAGCCTGACCAACGTGGTGAAACCCTGTCT...
ACTTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCAGCCTAAGTCTCACTTTTTGCACCTATACAACAGGGATAGTAGTATCTACCTCATGGGTTATGGTATTCCATTTTATATATACATATAAAATACTATATATGGTATCGAAACTCATAGGAAACTTGCAAAAAATTTGCCTTAAAAAAAACTCCCTGGGCCGGGCATAGTGGCTCACACCTGTAATCCCAGCACTTTGGAAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCAAAACCAGCCTGACCAACGTGGTGAAACCCTGTCT...
benign
181,542
Regarding the variant at chromosome 11 and position 85631741, affecting gene TMEM126B (transmembrane protein 126B): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Mitochondrial_complex_1_deficiency,_nuclear_type_29']
GGTTACTCATGTTATTGACGTCTGCCAAGACAGCAGATGTCTTAGTACAATAGATGGGTTAGGTATAGAATCTCCCTTAGATGTTACTATCCCTTATACTTTCCATTTGGGTGTCAGGGAGAGGGAAAAGATGTAAGTCTAGTCACTGAAAAATTGTAATTTGTAAAATATTTTACCTTTTTTTCCCCCTGCCCTCTCCAGAAATGTTACAGAAAAAGATTGAGTACATTTCTGCCATGATGCAGAGAAAGAAACTGGTCCATTATTACTCATTGTGTAACACCATAAGAAGGTTCAAAGGAGCTCATACCTTCTGTATG...
GGTTACTCATGTTATTGACGTCTGCCAAGACAGCAGATGTCTTAGTACAATAGATGGGTTAGGTATAGAATCTCCCTTAGATGTTACTATCCCTTATACTTTCCATTTGGGTGTCAGGGAGAGGGAAAAGATGTAAGTCTAGTCACTGAAAAATTGTAATTTGTAAAATATTTTACCTTTTTTTCCCCCTGCCCTCTCCAGAAATGTTACAGAAAAAGATTGAGTACATTTCTGCCATGATGCAGAGAAAGAAACTGGTCCATTATTACTCATTGTGTAACACCATAAGAAGGTTCAAAGGAGCTCATACCTTCTGTATG...
pathogenic
181,645
Does the variant impacting TMEM126B (transmembrane protein 126B) on chromosome 11, position 85634170, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Mitochondrial_complex_1_deficiency,_nuclear_type_29', 'TMEM126B-related_disorder']
GGTACTTATATTTAATTGGTGAGTAATTATAATCAGTTTAGGATTGATTATCTCAGCCACAGTACTTAGTACAGCAAAAGGGAATACAGATTTCATGGTATAAATATAGTCTCACATTAACATATTGACTTTTTTTTTTGAGATAAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAATCTCCAGCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGTGTACCACCACAACCAGCTAATTTTTGTATTTTTAGTAGAGATGGTTTAACC...
GGTACTTATATTTAATTGGTGAGTAATTATAATCAGTTTAGGATTGATTATCTCAGCCACAGTACTTAGTACAGCAAAAGGGAATACAGATTTCATGGTATAAATATAGTCTCACATTAACATATTGACTTTTTTTTTTGAGATAAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAATCTCCAGCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGTGTACCACCACAACCAGCTAATTTTTGTATTTTTAGTAGAGATGGTTTAACC...
pathogenic
181,647
Does the variant on chromosome 11 at location 85634199 affecting gene TMEM126B (transmembrane protein 126B) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Mitochondrial_complex_1_deficiency,_nuclear_type_29', 'Mitochondrial_complex_I_deficiency,_nuclear_type_1']
TAATCAGTTTAGGATTGATTATCTCAGCCACAGTACTTAGTACAGCAAAAGGGAATACAGATTTCATGGTATAAATATAGTCTCACATTAACATATTGACTTTTTTTTTTGAGATAAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAATCTCCAGCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGTGTACCACCACAACCAGCTAATTTTTGTATTTTTAGTAGAGATGGTTTAACCATGTTGGCCAGACTGGCCATTTTGACTTT...
TAATCAGTTTAGGATTGATTATCTCAGCCACAGTACTTAGTACAGCAAAAGGGAATACAGATTTCATGGTATAAATATAGTCTCACATTAACATATTGACTTTTTTTTTTGAGATAAGAGTCTCACTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCTCGGCTCACTGCAATCTCCAGCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCGTGTACCACCACAACCAGCTAATTTTTGTATTTTTAGTAGAGATGGTTTAACCATGTTGGCCAGACTGGCCATTTTGACTTT...
pathogenic
181,648
Is the genetic variant on chromosome 11, position 85635686, gene TMEM126B (transmembrane protein 126B), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Mitochondrial_complex_1_deficiency,_nuclear_type_29']
ATGTATCTGGGACTAATGAAGAAATAGAAGGCCTAACCAAATGTAAACAGCTTTTTTTTAGATGAACTTAAGCAAAGTAAATCTTTTAGTTGCAGGAAAGGTATTCTTGGATTTGGGTAGCTCATAAAATTTGGCTGCATTGGAACATATTTATATTTATTTGTGGCCAAAATTATTTAAAAGAGCTCTATTTTAGAATTACTGTAAATATTCTTAGAAAGAGAATCATGTCCTCTCATTAGAATACAAGTTCTATGAGGGGTGGGAAATTTCTTTTTTTCTTTTGCTTTGTTTACTGTCCTATCTTAAGCACTTAGAAA...
ATGTATCTGGGACTAATGAAGAAATAGAAGGCCTAACCAAATGTAAACAGCTTTTTTTTAGATGAACTTAAGCAAAGTAAATCTTTTAGTTGCAGGAAAGGTATTCTTGGATTTGGGTAGCTCATAAAATTTGGCTGCATTGGAACATATTTATATTTATTTGTGGCCAAAATTATTTAAAAGAGCTCTATTTTAGAATTACTGTAAATATTCTTAGAAAGAGAATCATGTCCTCTCATTAGAATACAAGTTCTATGAGGGGTGGGAAATTTCTTTTTTTCTTTTGCTTTGTTTACTGTCCTATCTTAAGCACTTAGAAA...
pathogenic
181,651
A genetic variant on chromosome 11, position 86277996, affects the gene EED (embryonic ectoderm development). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
benign
ATTTAAATGCCTGTGAACCCCACAGGGCTGCCACCTGTCACTATATTATGTAGGCTGTCCAGTAAAACTCTAGGGGCACTGTTCACTTACATGAGGATTTCTGAATCCTGGTGCTATTTAGTTTAGGCCAGATAATTCTTTTTTTTGTAGGGGGTTTCCTGTGCATTATAAGATATTTAGTAGCATCTTTGGCCTCTACCCATTAGAGCACAGACACATTGTCAAATGTCCCTTCGTGGGCAAACCACTGACCTAGACAGTAATATGAATAGTGCCCACAGTTTTGCAATTTTTTCTCATTGTATTCTTTACCACTTACT...
ATTTAAATGCCTGTGAACCCCACAGGGCTGCCACCTGTCACTATATTATGTAGGCTGTCCAGTAAAACTCTAGGGGCACTGTTCACTTACATGAGGATTTCTGAATCCTGGTGCTATTTAGTTTAGGCCAGATAATTCTTTTTTTTGTAGGGGGTTTCCTGTGCATTATAAGATATTTAGTAGCATCTTTGGCCTCTACCCATTAGAGCACAGACACATTGTCAAATGTCCCTTCGTGGGCAAACCACTGACCTAGACAGTAATATGAATAGTGCCCACAGTTTTGCAATTTTTTCTCATTGTATTCTTTACCACTTACT...
benign
181,711
The mutation in gene FZD4 at chromosome 11, position 86951253—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Exudative_vitreoretinopathy_1']
ACAATCGACTTTACATGCATCTTGATGTCAGAGAGCTCAAGAACCACACAAAAACAAAAAGGAAAGAAGAAAGGGAAATGTCAAACTATGGGCATAAGGCTCAAACCAAATTTTTAAAAAAGAGGAAATGCTTACTTCCAGAATTTGACCACCTTTTTGGAATTTTGAGTCCCTGGAAATGTTTTTCCACAAAGTGTGATTGAAAAAAAAAAAAAGAAAAAAAAAAGCTTCCCTTCCTATTTTTTTAAGGCATGAATTAATAAATAAATGTCATTGCAAAGCAGTTGCTGAAGCAGACAGGTATGAGTTACAAGGAGAGC...
ACAATCGACTTTACATGCATCTTGATGTCAGAGAGCTCAAGAACCACACAAAAACAAAAAGGAAAGAAGAAAGGGAAATGTCAAACTATGGGCATAAGGCTCAAACCAAATTTTTAAAAAAGAGGAAATGCTTACTTCCAGAATTTGACCACCTTTTTGGAATTTTGAGTCCCTGGAAATGTTTTTCCACAAAGTGTGATTGAAAAAAAAAAAAAGAAAAAAAAAAGCTTCCCTTCCTATTTTTTTAAGGCATGAATTAATAAATAAATGTCATTGCAAAGCAGTTGCTGAAGCAGACAGGTATGAGTTACAAGGAGAGC...
pathogenic
181,730
Considering the variant on chromosome 11, location 86951470, involving gene FZD4, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Exudative_retinopathy', 'Exudative_vitreoretinopathy_1', 'Familial_exudative_vitreoretinopathy', 'Retinal_dystrophy']
AAAAAAAAAGCTTCCCTTCCTATTTTTTTAAGGCATGAATTAATAAATAAATGTCATTGCAAAGCAGTTGCTGAAGCAGACAGGTATGAGTTACAAGGAGAGCAACCTGTGACATAGTCAATTTGTCCCCAAGATCTCATGATTAGAACGCCTAAGGCAAGGTAAGAGAAAGGCCAGTTACAGTTTTAAGAGAAGTGCAATTTTCGAGAGGCTGCTGGGGGTACCCCCTTGTGAAGAACGTATGCATAAATTTTAAAAGCTTTGGATACCTCTGCTAAAGGCAATTAAGACCTGGGCTATTAGAGTTTGCAGTTCATTTC...
AAAAAAAAAGCTTCCCTTCCTATTTTTTTAAGGCATGAATTAATAAATAAATGTCATTGCAAAGCAGTTGCTGAAGCAGACAGGTATGAGTTACAAGGAGAGCAACCTGTGACATAGTCAATTTGTCCCCAAGATCTCATGATTAGAACGCCTAAGGCAAGGTAAGAGAAAGGCCAGTTACAGTTTTAAGAGAAGTGCAATTTTCGAGAGGCTGCTGGGGGTACCCCCTTGTGAAGAACGTATGCATAAATTTTAAAAGCTTTGGATACCTCTGCTAAAGGCAATTAAGACCTGGGCTATTAGAGTTTGCAGTTCATTTC...
pathogenic
181,736
Benign or pathogenic: chromosome 11, position 86955036, gene FZD4 (frizzled class receptor 4) variant? Disease(s) if pathogenic?
pathogenic; ['Familial_exudative_vitreoretinopathy']
AAAATGGCCCAAATGAGACACTGTTAGACTCAAGGATGGGATGCAGATTGAGGTCTCTGGTCACTAGGGATTTGTTTGGCCAGGTTTCCTCAATGAATAATAATGAAGCACAATAGGAAAATGTAAATGTTAAGTCGCTGAAACTGCAGTACCAGCAGGGGAGAGTCCAGTTGCTGTCCTCAATTCCTCCAGCATTGATAAACAGTCTGCTTGGCTCCTTACAGATGTTGTCTATGAAGTCTAGAGTTACAAGTAACTATTTTCCAGCATGTAAAGGGATCCAGTCTTGTCCTTCAAAACAGCTTGGCCGCTTTCCCCAG...
AAAATGGCCCAAATGAGACACTGTTAGACTCAAGGATGGGATGCAGATTGAGGTCTCTGGTCACTAGGGATTTGTTTGGCCAGGTTTCCTCAATGAATAATAATGAAGCACAATAGGAAAATGTAAATGTTAAGTCGCTGAAACTGCAGTACCAGCAGGGGAGAGTCCAGTTGCTGTCCTCAATTCCTCCAGCATTGATAAACAGTCTGCTTGGCTCCTTACAGATGTTGTCTATGAAGTCTAGAGTTACAAGTAACTATTTTCCAGCATGTAAAGGGATCCAGTCTTGTCCTTCAAAACAGCTTGGCCGCTTTCCCCAG...
pathogenic
181,744
A genetic variant on chromosome 11, position 88604708, affects the gene GRM5 (glutamate metabotropic receptor 5). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
benign
TCAGGCTGTTGTATAATGTTAGAAGTTGAAGCCCAGGAGACAGAGTTAAAATTTTGACTCTATCATTTACTAGACTGTGTTTTTGGGCAAGTCATTGAACTTTTGTAAGCTTTGGTTTTCTTTAGCTGGAAAAAAGAATGGTAACATTACTTACCTCATAGGATTAAAAAGTAGAACACTTGGCTTAGTCTTTGGCTCAGAACACACACTCAATATATGCTAGTTATAATTTTTTTTGTAAAAGTAACTGGATTATTTGGAGAAACAAAAGGTGGTAAATCACCTTTTCCTGAGTCTGCTTCATGCCCTTAGAGGCCAAC...
TCAGGCTGTTGTATAATGTTAGAAGTTGAAGCCCAGGAGACAGAGTTAAAATTTTGACTCTATCATTTACTAGACTGTGTTTTTGGGCAAGTCATTGAACTTTTGTAAGCTTTGGTTTTCTTTAGCTGGAAAAAAGAATGGTAACATTACTTACCTCATAGGATTAAAAAGTAGAACACTTGGCTTAGTCTTTGGCTCAGAACACACACTCAATATATGCTAGTTATAATTTTTTTTGTAAAAGTAACTGGATTATTTGGAGAAACAAAAGGTGGTAAATCACCTTTTCCTGAGTCTGCTTCATGCCCTTAGAGGCCAAC...
benign
181,796
Does the variant impacting TYR (tyrosinase) on chromosome 11, position 89178026, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Ocular_albinism', 'Oculocutaneous_albinism_type_1A', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
AAAGAAAGAGAGAGAGAAAAGATTAAGCCTCCTTGTGGAGATCATGTGATGACTTCCTGATTCCAGCCAGAGGCAGCATTTCCATGGAAACTTCTCTTCCTCTTCACCCACACACTGCTCCATGTACCTGCAAAGCCTGTTCTGTCTCAAAAAAGTTGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCT...
AAAGAAAGAGAGAGAGAAAAGATTAAGCCTCCTTGTGGAGATCATGTGATGACTTCCTGATTCCAGCCAGAGGCAGCATTTCCATGGAAACTTCTCTTCCTCTTCACCCACACACTGCTCCATGTACCTGCAAAGCCTGTTCTGTCTCAAAAAAGTTGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCT...
pathogenic
181,809
Considering the genetic mutation at chromosome 11, position 89178129, impacting TYR (tyrosinase): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TCACCCACACACTGCTCCATGTACCTGCAAAGCCTGTTCTGTCTCAAAAAAGTTGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTA...
TCACCCACACACTGCTCCATGTACCTGCAAAGCCTGTTCTGTCTCAAAAAAGTTGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTA...
pathogenic
181,819
Does the variant impacting TYR (tyrosinase) on chromosome 11, position 89178168, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TGTCTCAAAAAAGTTGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTT...
TGTCTCAAAAAAGTTGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTT...
pathogenic
181,821
Evaluate the clinical significance of the mutation at chromosome 11, position 89178172 in gene TYR (tyrosinase): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TCAAAAAAGTTGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGT...
TCAAAAAAGTTGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGT...
pathogenic
181,822
A genetic variant on chromosome 11, position 89178182, affects the gene TYR (tyrosinase). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACA...
TGTTTGGATGAGCCGTGACTTTTTTTTTTCTTAAATAATGAGACAAACTCCAGAAAAAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACA...
pathogenic
181,823
Evaluate this variant at chromosome 11, position 89178238, gene TYR (tyrosinase): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Abnormality_of_the_skin', 'Oculocutaneous_albinism_type_1A', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
AAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACAAAGTCTTTAAGCCCCTCCATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGG...
AAGAGAAAAAAGCAGAGCAGTCTGACATTCCGGCATCATCGAAATAGTGATGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACAAAGTCTTTAAGCCCCTCCATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGG...
pathogenic
181,833
Evaluate this variant at chromosome 11, position 89178288, gene TYR (tyrosinase): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Oculocutaneous_albinism', 'Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACAAAGTCTTTAAGCCCCTCCATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCT...
TGGCTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACAAAGTCTTTAAGCCCCTCCATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCT...
pathogenic
181,837
A genetic variant on chromosome 11, position 89178291, affects the gene TYR (tyrosinase). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
CTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACAAAGTCTTTAAGCCCCTCCATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCTCTA...
CTTTTCCTAGAATGCTTCAGCTAAGGACCCAAATACTAATGATCTCCTCAAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACAAAGTCTTTAAGCCCCTCCATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCTCTA...
pathogenic
181,838
Variant at chromosome position 89178340, chromosome 11, gene TYR (tyrosinase): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Oculocutaneous_albinism_type_1A']
AAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACAAAGTCTTTAAGCCCCTCCATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCTCTACACATTTCCCCTGTCTCAGGAGTTGTATATATTCTCAGTTGTCTGTCCA...
AAAGCTTTCACTTTCTTTTACTTTTTCATTAATTTCAGTGGACCCCCAAACTTTAAGTATGGAAGAGGACAAAGAAGGAAGCTTCAGAGGGGCAACTTTGATTTGACTACTCTTTTTGTCACTCTTCAGCTCACAAAAGAGCTCACTTTAGTTCAAAACACAAAGTCTTTAAGCCCCTCCATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCTCTACACATTTCCCCTGTCTCAGGAGTTGTATATATTCTCAGTTGTCTGTCCA...
pathogenic
181,841
Assess the variant on chromosome 11, position 89178520, impacting TYR (tyrosinase): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN', 'TYR-related_disorder']
ATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCTCTACACATTTCCCCTGTCTCAGGAGTTGTATATATTCTCAGTTGTCTGTCCAACTTATGCCCACTCTTTGAGATATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTA...
ATAGATTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCTCTACACATTTCCCCTGTCTCAGGAGTTGTATATATTCTCAGTTGTCTGTCCAACTTATGCCCACTCTTTGAGATATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTA...
pathogenic
181,846
Classify the chromosome 11 variant at position 89178525 affecting gene TYR (tyrosinase) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN', 'TYR-related_disorder']
TTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCTCTACACATTTCCCCTGTCTCAGGAGTTGTATATATTCTCAGTTGTCTGTCCAACTTATGCCCACTCTTTGAGATATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCAT...
TTGGTCCCAGGTTTAATTTTCTATGATGTGTGGAGGCCTCAGTTTAATGCTCCAACTTGATAGATGAAACACAGTTCCCACCTCTACACATTTCCCCTGTCTCAGGAGTTGTATATATTCTCAGTTGTCTGTCCAACTTATGCCCACTCTTTGAGATATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCAT...
pathogenic
181,847
Considering the genetic mutation at chromosome 11, position 89178601, impacting TYR (tyrosinase): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
CCCACCTCTACACATTTCCCCTGTCTCAGGAGTTGTATATATTCTCAGTTGTCTGTCCAACTTATGCCCACTCTTTGAGATATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCT...
CCCACCTCTACACATTTCCCCTGTCTCAGGAGTTGTATATATTCTCAGTTGTCTGTCCAACTTATGCCCACTCTTTGAGATATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCT...
pathogenic
181,855
The chromosome 11, position 89178648 genetic variant in gene TYR (tyrosinase): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
GTTGTCTGTCCAACTTATGCCCACTCTTTGAGATATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCTGAAGAAATATATTTCTCCTTTTTCATTCACTCACTAATTGAGAATGT...
GTTGTCTGTCCAACTTATGCCCACTCTTTGAGATATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCTGAAGAAATATATTTCTCCTTTTTCATTCACTCACTAATTGAGAATGT...
pathogenic
181,860
The genetic variant at chromosome 11, position 89178681, affecting gene TYR (tyrosinase): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN', 'TYR-related_disorder']
TATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCTGAAGAAATATATTTCTCCTTTTTCATTCACTCACTAATTGAGAATGTCTTTGCACAAAACACATTGCAAAAACATTTTCA...
TATTAATCAAGGCACTCCCTTGATAACACTTGCATATTATTATCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCTGAAGAAATATATTTCTCCTTTTTCATTCACTCACTAATTGAGAATGTCTTTGCACAAAACACATTGCAAAAACATTTTCA...
pathogenic
181,863
Clinical impact (benign or pathogenic) of the variant at chromosome 11, location 89178723, gene TYR (tyrosinase): what disease(s) if pathogenic?
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCTGAAGAAATATATTTCTCCTTTTTCATTCACTCACTAATTGAGAATGTCTTTGCACAAAACACATTGCAAAAACATTTTCAAAAAAATTCCTAATTTCTAGAATTGATAGGAAAAACAATATG...
TCAAAATTATGCAATTCTTTCTAATATCAGCCCACAAATACATCTCTTCCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCTGAAGAAATATATTTCTCCTTTTTCATTCACTCACTAATTGAGAATGTCTTTGCACAAAACACATTGCAAAAACATTTTCAAAAAAATTCCTAATTTCTAGAATTGATAGGAAAAACAATATG...
pathogenic
181,869
Chromosome 11, position 89178771, gene TYR (tyrosinase): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
CCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCTGAAGAAATATATTTCTCCTTTTTCATTCACTCACTAATTGAGAATGTCTTTGCACAAAACACATTGCAAAAACATTTTCAAAAAAATTCCTAATTTCTAGAATTGATAGGAAAAACAATATGGCTACAGCATTGGAGAGAGAGAGAAAGGAGAGAGGAGAAAGGAGAGAG...
CCATTAAAAGTTTGACTTAATTATCTATACTACTCATTTGAAAACTAACATAGTTAAGTTGTATTTTTAGCCATGAATTTCAGTTTCCCTAGCTCACTATACACAGAGAAGGAACTTTTGAAATAATTGAGATGATCAAAAATATTTGCTGAAGAAATATATTTCTCCTTTTTCATTCACTCACTAATTGAGAATGTCTTTGCACAAAACACATTGCAAAAACATTTTCAAAAAAATTCCTAATTTCTAGAATTGATAGGAAAAACAATATGGCTACAGCATTGGAGAGAGAGAGAAAGGAGAGAGGAGAAAGGAGAGAG...
pathogenic
181,871
Variant at chromosome 11, position 89191198, gene TYR (tyrosinase): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TGGAAAACTTGGGTTGCCATCACAACACTGCCATTTATTTGCCATATAACCTGAGAAATGCCACTTACCCTCTCTGAGTCTCATTTTCCTTATTTGTGAAGCGAAATGTATTGTTTTGTGATGTAAATGAAACAATGCATGTGCCGTGTTTTCTTAAAAAGTTTTGCTTATAGAAAGGTGAGAAATTCTTATTTTTAAGACGGTATTTCTACAATGAAAATCACCTTGGTTCTAGCTAAAGGATCAGAGAAATTTCTTTTCTTAAAAAACAATCAACCACGAGTATTGTACTGCACATCAAAAAAAAAAGGGACAATAAT...
TGGAAAACTTGGGTTGCCATCACAACACTGCCATTTATTTGCCATATAACCTGAGAAATGCCACTTACCCTCTCTGAGTCTCATTTTCCTTATTTGTGAAGCGAAATGTATTGTTTTGTGATGTAAATGAAACAATGCATGTGCCGTGTTTTCTTAAAAAGTTTTGCTTATAGAAAGGTGAGAAATTCTTATTTTTAAGACGGTATTTCTACAATGAAAATCACCTTGGTTCTAGCTAAAGGATCAGAGAAATTTCTTTTCTTAAAAAACAATCAACCACGAGTATTGTACTGCACATCAAAAAAAAAAGGGACAATAAT...
pathogenic
181,874
Considering the genetic mutation at chromosome 11, position 89191242, impacting TYR (tyrosinase): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TATAACCTGAGAAATGCCACTTACCCTCTCTGAGTCTCATTTTCCTTATTTGTGAAGCGAAATGTATTGTTTTGTGATGTAAATGAAACAATGCATGTGCCGTGTTTTCTTAAAAAGTTTTGCTTATAGAAAGGTGAGAAATTCTTATTTTTAAGACGGTATTTCTACAATGAAAATCACCTTGGTTCTAGCTAAAGGATCAGAGAAATTTCTTTTCTTAAAAAACAATCAACCACGAGTATTGTACTGCACATCAAAAAAAAAAGGGACAATAATAGGATATTTTATGAACAAAAAGCACAAAATGAAACTATTTCTAG...
TATAACCTGAGAAATGCCACTTACCCTCTCTGAGTCTCATTTTCCTTATTTGTGAAGCGAAATGTATTGTTTTGTGATGTAAATGAAACAATGCATGTGCCGTGTTTTCTTAAAAAGTTTTGCTTATAGAAAGGTGAGAAATTCTTATTTTTAAGACGGTATTTCTACAATGAAAATCACCTTGGTTCTAGCTAAAGGATCAGAGAAATTTCTTTTCTTAAAAAACAATCAACCACGAGTATTGTACTGCACATCAAAAAAAAAAGGGACAATAATAGGATATTTTATGAACAAAAAGCACAAAATGAAACTATTTCTAG...
pathogenic
181,882
Considering the genetic mutation at chromosome 11, position 89191307, impacting TYR (tyrosinase): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Inborn_genetic_diseases', 'Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN', 'TYR-related_disorder']
ATTGTTTTGTGATGTAAATGAAACAATGCATGTGCCGTGTTTTCTTAAAAAGTTTTGCTTATAGAAAGGTGAGAAATTCTTATTTTTAAGACGGTATTTCTACAATGAAAATCACCTTGGTTCTAGCTAAAGGATCAGAGAAATTTCTTTTCTTAAAAAACAATCAACCACGAGTATTGTACTGCACATCAAAAAAAAAAGGGACAATAATAGGATATTTTATGAACAAAAAGCACAAAATGAAACTATTTCTAGTCCTTGACATTCTGAATATAATATAGATTAATGTTTTTAAAGCTACTGTTTATTGAGTGTTTTCT...
ATTGTTTTGTGATGTAAATGAAACAATGCATGTGCCGTGTTTTCTTAAAAAGTTTTGCTTATAGAAAGGTGAGAAATTCTTATTTTTAAGACGGTATTTCTACAATGAAAATCACCTTGGTTCTAGCTAAAGGATCAGAGAAATTTCTTTTCTTAAAAAACAATCAACCACGAGTATTGTACTGCACATCAAAAAAAAAAGGGACAATAATAGGATATTTTATGAACAAAAAGCACAAAATGAAACTATTTCTAGTCCTTGACATTCTGAATATAATATAGATTAATGTTTTTAAAGCTACTGTTTATTGAGTGTTTTCT...
pathogenic
181,890
Variant in gene TYR (tyrosinase), located at chromosome 11 position 89191317: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
GATGTAAATGAAACAATGCATGTGCCGTGTTTTCTTAAAAAGTTTTGCTTATAGAAAGGTGAGAAATTCTTATTTTTAAGACGGTATTTCTACAATGAAAATCACCTTGGTTCTAGCTAAAGGATCAGAGAAATTTCTTTTCTTAAAAAACAATCAACCACGAGTATTGTACTGCACATCAAAAAAAAAAGGGACAATAATAGGATATTTTATGAACAAAAAGCACAAAATGAAACTATTTCTAGTCCTTGACATTCTGAATATAATATAGATTAATGTTTTTAAAGCTACTGTTTATTGAGTGTTTTCTGTTGGTCATG...
GATGTAAATGAAACAATGCATGTGCCGTGTTTTCTTAAAAAGTTTTGCTTATAGAAAGGTGAGAAATTCTTATTTTTAAGACGGTATTTCTACAATGAAAATCACCTTGGTTCTAGCTAAAGGATCAGAGAAATTTCTTTTCTTAAAAAACAATCAACCACGAGTATTGTACTGCACATCAAAAAAAAAAGGGACAATAATAGGATATTTTATGAACAAAAAGCACAAAATGAAACTATTTCTAGTCCTTGACATTCTGAATATAATATAGATTAATGTTTTTAAAGCTACTGTTTATTGAGTGTTTTCTGTTGGTCATG...
pathogenic
181,891
A mutation at chromosome position 89227831 on chromosome 11 in gene TYR (tyrosinase): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
GTAGGAAAATTATAGTTAACAACAATTTATTCTATTGTATATTTTTAAATAGCTAGAATAGAAGATTTGTAAGATTCCCAACACAAAGAAAAGATAAATGATCGAGGTGATTGATATTCCAATTACTCTGATTTGATCATTACACCTTGTACATTATAGGCATCAAAATATCACATGTACCCCAAAGATATGTACAATTGTTACATACCAATGAAAAATATAAAACTTTAAAAATTCTTTTAAATTAAAAAAATCAGTTTGGGACCTACTTTAAAAAGTGTGAGAGTATACACTTTAAAAAGTGTGAGAGTTTTAAATTT...
GTAGGAAAATTATAGTTAACAACAATTTATTCTATTGTATATTTTTAAATAGCTAGAATAGAAGATTTGTAAGATTCCCAACACAAAGAAAAGATAAATGATCGAGGTGATTGATATTCCAATTACTCTGATTTGATCATTACACCTTGTACATTATAGGCATCAAAATATCACATGTACCCCAAAGATATGTACAATTGTTACATACCAATGAAAAATATAAAACTTTAAAAATTCTTTTAAATTAAAAAAATCAGTTTGGGACCTACTTTAAAAAGTGTGAGAGTATACACTTTAAAAAGTGTGAGAGTTTTAAATTT...
pathogenic
181,908
Is the genetic change at chromosome 11, position 89227948, within gene TYR (tyrosinase) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TCCAATTACTCTGATTTGATCATTACACCTTGTACATTATAGGCATCAAAATATCACATGTACCCCAAAGATATGTACAATTGTTACATACCAATGAAAAATATAAAACTTTAAAAATTCTTTTAAATTAAAAAAATCAGTTTGGGACCTACTTTAAAAAGTGTGAGAGTATACACTTTAAAAAGTGTGAGAGTTTTAAATTTTTCATTTGGTGCTACTCAGAGATAAAATCTTGAAAACAACTTCTATGAAGAACATTGTCCTCAGTGACATGATTTATTGCTACATAGCAAAGGAAGTAAACCATTGTATTTAGGAGC...
TCCAATTACTCTGATTTGATCATTACACCTTGTACATTATAGGCATCAAAATATCACATGTACCCCAAAGATATGTACAATTGTTACATACCAATGAAAAATATAAAACTTTAAAAATTCTTTTAAATTAAAAAAATCAGTTTGGGACCTACTTTAAAAAGTGTGAGAGTATACACTTTAAAAAGTGTGAGAGTTTTAAATTTTTCATTTGGTGCTACTCAGAGATAAAATCTTGAAAACAACTTCTATGAAGAACATTGTCCTCAGTGACATGATTTATTGCTACATAGCAAAGGAAGTAAACCATTGTATTTAGGAGC...
pathogenic
181,921
Is the chromosome 11, position 89284824 variant in TYR (tyrosinase) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Oculocutaneous_albinism_type_1B']
ATCACTAAAGGCACTGCTCACATATGCAAGGCTTTGGCATTTCTAAAACAGCATATGTTATGTCTCATCAATTTTAAAGTTTTTCCAGTATAGTCATAATACTTAGGAGGGGGAAGAAGAGAAGAGAGGAGCTGTGAGAAAGATAATAGCTTTTATGTACCACTTAACTGTGTATTTTGTGTTATTTTAATTAATCCTTACATTACCTTCATGACATAAATATAATTCCCATTTTGTAGAATAAAGAAGATCAAACAGATACAATTTTACAAATCTTCCCTGTCTCAACCTATAGAACTCAGATTTTTACACAGTTCTTT...
ATCACTAAAGGCACTGCTCACATATGCAAGGCTTTGGCATTTCTAAAACAGCATATGTTATGTCTCATCAATTTTAAAGTTTTTCCAGTATAGTCATAATACTTAGGAGGGGGAAGAAGAGAAGAGAGGAGCTGTGAGAAAGATAATAGCTTTTATGTACCACTTAACTGTGTATTTTGTGTTATTTTAATTAATCCTTACATTACCTTCATGACATAAATATAATTCCCATTTTGTAGAATAAAGAAGATCAAACAGATACAATTTTACAAATCTTCCCTGTCTCAACCTATAGAACTCAGATTTTTACACAGTTCTTT...
pathogenic
181,931
Evaluate if the mutation on chromosome 11 at position 89284852 in TYR (tyrosinase) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Oculocutaneous_albinism_type_1A']
AGGCTTTGGCATTTCTAAAACAGCATATGTTATGTCTCATCAATTTTAAAGTTTTTCCAGTATAGTCATAATACTTAGGAGGGGGAAGAAGAGAAGAGAGGAGCTGTGAGAAAGATAATAGCTTTTATGTACCACTTAACTGTGTATTTTGTGTTATTTTAATTAATCCTTACATTACCTTCATGACATAAATATAATTCCCATTTTGTAGAATAAAGAAGATCAAACAGATACAATTTTACAAATCTTCCCTGTCTCAACCTATAGAACTCAGATTTTTACACAGTTCTTTGTGTAACTTGACCTACAGTAGATACTCA...
AGGCTTTGGCATTTCTAAAACAGCATATGTTATGTCTCATCAATTTTAAAGTTTTTCCAGTATAGTCATAATACTTAGGAGGGGGAAGAAGAGAAGAGAGGAGCTGTGAGAAAGATAATAGCTTTTATGTACCACTTAACTGTGTATTTTGTGTTATTTTAATTAATCCTTACATTACCTTCATGACATAAATATAATTCCCATTTTGTAGAATAAAGAAGATCAAACAGATACAATTTTACAAATCTTCCCTGTCTCAACCTATAGAACTCAGATTTTTACACAGTTCTTTGTGTAACTTGACCTACAGTAGATACTCA...
pathogenic
181,933
The chromosome 11, position 89295166 genetic variant in gene TYR (tyrosinase): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Oculocutaneous_albinism_type_1', 'Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
CTATTAAATGATACATTTAAATTGTCCAACTAATTATAGAATCATCTGTTTTATTTGAAATGTATGGCTTCAGGAAAATTTTGAATTTAATTTGATGTGATTTATTTCTTAGGTTGCTCAGTATGATGGCATCTCAAAAACATGGGCTTACCCATGATTTTTGTTTGGTGAATGTTTAAAAACAACACAAAAAGCCATTTATGTACACATTTTATGCATACACACACACACACACACACACACACACACACACAACCCAGAATGGTCCTTAGGATAAACGCAAGTTCTGATTGAGTAATGACTATGGAAATTTTCCCCGA...
CTATTAAATGATACATTTAAATTGTCCAACTAATTATAGAATCATCTGTTTTATTTGAAATGTATGGCTTCAGGAAAATTTTGAATTTAATTTGATGTGATTTATTTCTTAGGTTGCTCAGTATGATGGCATCTCAAAAACATGGGCTTACCCATGATTTTTGTTTGGTGAATGTTTAAAAACAACACAAAAAGCCATTTATGTACACATTTTATGCATACACACACACACACACACACACACACACACACACAACCCAGAATGGTCCTTAGGATAAACGCAAGTTCTGATTGAGTAATGACTATGGAAATTTTCCCCGA...
pathogenic
181,940
A genetic variant on chromosome 11, position 89295202, affects the gene TYR (tyrosinase). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TAGAATCATCTGTTTTATTTGAAATGTATGGCTTCAGGAAAATTTTGAATTTAATTTGATGTGATTTATTTCTTAGGTTGCTCAGTATGATGGCATCTCAAAAACATGGGCTTACCCATGATTTTTGTTTGGTGAATGTTTAAAAACAACACAAAAAGCCATTTATGTACACATTTTATGCATACACACACACACACACACACACACACACACACACAACCCAGAATGGTCCTTAGGATAAACGCAAGTTCTGATTGAGTAATGACTATGGAAATTTTCCCCGACATTTAGAAATGCTGTTCTCTAATGCAGAGGAAATA...
TAGAATCATCTGTTTTATTTGAAATGTATGGCTTCAGGAAAATTTTGAATTTAATTTGATGTGATTTATTTCTTAGGTTGCTCAGTATGATGGCATCTCAAAAACATGGGCTTACCCATGATTTTTGTTTGGTGAATGTTTAAAAACAACACAAAAAGCCATTTATGTACACATTTTATGCATACACACACACACACACACACACACACACACACACAACCCAGAATGGTCCTTAGGATAAACGCAAGTTCTGATTGAGTAATGACTATGGAAATTTTCCCCGACATTTAGAAATGCTGTTCTCTAATGCAGAGGAAATA...
pathogenic
181,941
Variant in TYR (tyrosinase), chromosome 11, position 89295228—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN']
TATGGCTTCAGGAAAATTTTGAATTTAATTTGATGTGATTTATTTCTTAGGTTGCTCAGTATGATGGCATCTCAAAAACATGGGCTTACCCATGATTTTTGTTTGGTGAATGTTTAAAAACAACACAAAAAGCCATTTATGTACACATTTTATGCATACACACACACACACACACACACACACACACACACAACCCAGAATGGTCCTTAGGATAAACGCAAGTTCTGATTGAGTAATGACTATGGAAATTTTCCCCGACATTTAGAAATGCTGTTCTCTAATGCAGAGGAAATAATACATCATTTTATGAATACGTTCAT...
TATGGCTTCAGGAAAATTTTGAATTTAATTTGATGTGATTTATTTCTTAGGTTGCTCAGTATGATGGCATCTCAAAAACATGGGCTTACCCATGATTTTTGTTTGGTGAATGTTTAAAAACAACACAAAAAGCCATTTATGTACACATTTTATGCATACACACACACACACACACACACACACACACACACAACCCAGAATGGTCCTTAGGATAAACGCAAGTTCTGATTGAGTAATGACTATGGAAATTTTCCCCGACATTTAGAAATGCTGTTCTCTAATGCAGAGGAAATAATACATCATTTTATGAATACGTTCAT...
pathogenic
181,942
The mutation impacting TYR (tyrosinase) on chromosome 11 at position 89295242: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Oculocutaneous_albinism', 'Oculocutaneous_albinism_type_1A', 'Oculocutaneous_albinism_type_1B', 'SKIN/HAIR/EYE_PIGMENTATION_3,_LIGHT/DARK_SKIN', 'TYR-related_disorder']
AATTTTGAATTTAATTTGATGTGATTTATTTCTTAGGTTGCTCAGTATGATGGCATCTCAAAAACATGGGCTTACCCATGATTTTTGTTTGGTGAATGTTTAAAAACAACACAAAAAGCCATTTATGTACACATTTTATGCATACACACACACACACACACACACACACACACACACAACCCAGAATGGTCCTTAGGATAAACGCAAGTTCTGATTGAGTAATGACTATGGAAATTTTCCCCGACATTTAGAAATGCTGTTCTCTAATGCAGAGGAAATAATACATCATTTTATGAATACGTTCATAGAAGAATAAGATA...
AATTTTGAATTTAATTTGATGTGATTTATTTCTTAGGTTGCTCAGTATGATGGCATCTCAAAAACATGGGCTTACCCATGATTTTTGTTTGGTGAATGTTTAAAAACAACACAAAAAGCCATTTATGTACACATTTTATGCATACACACACACACACACACACACACACACACACACAACCCAGAATGGTCCTTAGGATAAACGCAAGTTCTGATTGAGTAATGACTATGGAAATTTTCCCCGACATTTAGAAATGCTGTTCTCTAATGCAGAGGAAATAATACATCATTTTATGAATACGTTCATAGAAGAATAAGATA...
pathogenic
181,943
Does the variant on chromosome 11 at location 93797687 affecting gene MED17 (mediator complex subunit 17) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Infantile_cerebral_and_cerebellar_atrophy_with_postnatal_progressive_microcephaly']
GTAGACTTGCCCTGGAGATCAGTTTGTATTTAGCTTTGCACTTGTTTTTTACATAAATTCTAAGGACTGTCGTCTTAGAAGGAAGTAGGTTTTAGTGGTGAGAAATTCCATCCTACTTCTCATGGGAGCAGGGAAGACTAACTGTCTTTTACGCAGTAAGACTGCCTACCTACTCTTATTTTAAAGGAAAAAACAAATTAATATATAGCTTTTTCACCAGTCTTTAGCCAGTTCAAGGGCAGCAGCCATATTATGTGTCAACAGAATTTGAATTGTTAAAATACGTGGTAGCTTATTATATTCATGAATAGTTTTTTTTT...
GTAGACTTGCCCTGGAGATCAGTTTGTATTTAGCTTTGCACTTGTTTTTTACATAAATTCTAAGGACTGTCGTCTTAGAAGGAAGTAGGTTTTAGTGGTGAGAAATTCCATCCTACTTCTCATGGGAGCAGGGAAGACTAACTGTCTTTTACGCAGTAAGACTGCCTACCTACTCTTATTTTAAAGGAAAAAACAAATTAATATATAGCTTTTTCACCAGTCTTTAGCCAGTTCAAGGGCAGCAGCCATATTATGTGTCAACAGAATTTGAATTGTTAAAATACGTGGTAGCTTATTATATTCATGAATAGTTTTTTTTT...
pathogenic
182,013
Clinically, how would you classify the variant at chromosome 11, position 94437318, gene MRE11 (MRE11 homolog, double strand break repair nuclease): benign or pathogenic? If pathogenic, specify the associated illness(es).
benign
TGAGGCCAAGCGCACTGGCTCACATCTGTAATCCAGGCACTTTGGGAGGTCGAGGTGGGTGGATCGCCTGAGCTCAGGAGTTCAAGACCAGCTTGGGCAACATGGCAAAACCCTGTGTCTACCAAAAATACAAAAAATTAGCCACGTGTGGTGGTGCACGTCTGTAATCCCAACTATTCAGGAGGCTGAGGTGGGAGAATTGCTTGAGCCCAGAAAGTGGAGGTTGCAGTGAGCCAAGATCGCACTACTGCACTCCAGTCTAGGCGACAGAATGAGGCACTGTCTCAAAAAATAAATAAATAAATAAAAAGAAAGAAAAG...
TGAGGCCAAGCGCACTGGCTCACATCTGTAATCCAGGCACTTTGGGAGGTCGAGGTGGGTGGATCGCCTGAGCTCAGGAGTTCAAGACCAGCTTGGGCAACATGGCAAAACCCTGTGTCTACCAAAAATACAAAAAATTAGCCACGTGTGGTGGTGCACGTCTGTAATCCCAACTATTCAGGAGGCTGAGGTGGGAGAATTGCTTGAGCCCAGAAAGTGGAGGTTGCAGTGAGCCAAGATCGCACTACTGCACTCCAGTCTAGGCGACAGAATGAGGCACTGTCTCAAAAAATAAATAAATAAATAAAAAGAAAGAAAAG...
benign
182,087
Classify the chromosome 11 variant at position 94447227 affecting gene MRE11 (MRE11 homolog, double strand break repair nuclease) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
GACAGTTCCTCTCTCTTTCGACCACTGTCCATATAGTGACCAACTACTTCACTTTCCTGTTTCCAGGGTCTCTCTGCCAAACAGAAACAGCATTTGTCTGAAAGTAAGAAATTATAAAACATAATTTTTGTTTTGTTTTGTTTTGTTTTTGAGACGGAGTCTCTCTCTGTTGCTAGGGTAGAGTCCAATGGCATGATCTTGGCTCACTGCAACCTCCAGTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGAC...
GACAGTTCCTCTCTCTTTCGACCACTGTCCATATAGTGACCAACTACTTCACTTTCCTGTTTCCAGGGTCTCTCTGCCAAACAGAAACAGCATTTGTCTGAAAGTAAGAAATTATAAAACATAATTTTTGTTTTGTTTTGTTTTGTTTTTGAGACGGAGTCTCTCTCTGTTGCTAGGGTAGAGTCCAATGGCATGATCTTGGCTCACTGCAACCTCCAGTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGAC...
pathogenic
182,096
Is the variant located on chromosome 11 at position 94447259, gene MRE11 (MRE11 homolog, double strand break repair nuclease), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Ataxia-telangiectasia-like_disorder_1']
ATAGTGACCAACTACTTCACTTTCCTGTTTCCAGGGTCTCTCTGCCAAACAGAAACAGCATTTGTCTGAAAGTAAGAAATTATAAAACATAATTTTTGTTTTGTTTTGTTTTGTTTTTGAGACGGAGTCTCTCTCTGTTGCTAGGGTAGAGTCCAATGGCATGATCTTGGCTCACTGCAACCTCCAGTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGACCGGGTTTCACCATGTTGGCCAGGCTGGTCTCG...
ATAGTGACCAACTACTTCACTTTCCTGTTTCCAGGGTCTCTCTGCCAAACAGAAACAGCATTTGTCTGAAAGTAAGAAATTATAAAACATAATTTTTGTTTTGTTTTGTTTTGTTTTTGAGACGGAGTCTCTCTCTGTTGCTAGGGTAGAGTCCAATGGCATGATCTTGGCTCACTGCAACCTCCAGTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGACCGGGTTTCACCATGTTGGCCAGGCTGGTCTCG...
pathogenic
182,100
Variant in gene MRE11 (MRE11 homolog, double strand break repair nuclease), located at chromosome 11 position 94447361: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
GTTTTGTTTTGTTTTTGAGACGGAGTCTCTCTCTGTTGCTAGGGTAGAGTCCAATGGCATGATCTTGGCTCACTGCAACCTCCAGTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGACCGGGTTTCACCATGTTGGCCAGGCTGGTCTCGATCTCCTGACCTCGTGATCTGCCTGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGATCCACTGTGCCTGGCCTATAAAACATGATTTTAAAAGCTTA...
GTTTTGTTTTGTTTTTGAGACGGAGTCTCTCTCTGTTGCTAGGGTAGAGTCCAATGGCATGATCTTGGCTCACTGCAACCTCCAGTTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGACCGGGTTTCACCATGTTGGCCAGGCTGGTCTCGATCTCCTGACCTCGTGATCTGCCTGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGATCCACTGTGCCTGGCCTATAAAACATGATTTTAAAAGCTTA...
pathogenic
182,107
Is the genetic mutation found on chromosome 11 at position 94447447, within the gene MRE11 (MRE11 homolog, double strand break repair nuclease), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
benign
TCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGACCGGGTTTCACCATGTTGGCCAGGCTGGTCTCGATCTCCTGACCTCGTGATCTGCCTGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGATCCACTGTGCCTGGCCTATAAAACATGATTTTAAAAGCTTACCCTCTTCAGTAACTCTAATGCATAGCAAAGATCTTTTAAAAAATAATTTATCCTGTGATCCTAATTGCCCTTATAACTTCCCAAT...
TCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCATGTGCCACCACGCCTGGCTGATTTTTGTATTTTTAGTAGAGACCGGGTTTCACCATGTTGGCCAGGCTGGTCTCGATCTCCTGACCTCGTGATCTGCCTGTCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGATCCACTGTGCCTGGCCTATAAAACATGATTTTAAAAGCTTACCCTCTTCAGTAACTCTAATGCATAGCAAAGATCTTTTAAAAAATAATTTATCCTGTGATCCTAATTGCCCTTATAACTTCCCAAT...
benign
182,110
Is the variant located on chromosome 11 at position 94456306, gene MRE11 (MRE11 homolog, double strand break repair nuclease), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
GAGATGGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAAACTCCTGAGCTCAAGAGATCCACCTGCCTCGGCCTCCCAAAGTGCTGAAATTACAGGTAAGTCACAATGCCCAGCCTGAAAGACTTTAAAGCATACTGTTTTTTCTCCAAATAGAAGAGCTAATAGTCTTGTTTGTCAGTATAAGTAATTTAAGCATGGCGCTGGGATTCATATTCTAAGCCAAATGATTCTGCAAAGCTGTGAATTACAGCTTGGCAGAGTTTCAGACTCCATTACCTAAGTTCTAAATAGTATGCTGAAAATGAAAAAATATATAATATC...
GAGATGGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAAACTCCTGAGCTCAAGAGATCCACCTGCCTCGGCCTCCCAAAGTGCTGAAATTACAGGTAAGTCACAATGCCCAGCCTGAAAGACTTTAAAGCATACTGTTTTTTCTCCAAATAGAAGAGCTAATAGTCTTGTTTGTCAGTATAAGTAATTTAAGCATGGCGCTGGGATTCATATTCTAAGCCAAATGATTCTGCAAAGCTGTGAATTACAGCTTGGCAGAGTTTCAGACTCCATTACCTAAGTTCTAAATAGTATGCTGAAAATGAAAAAATATATAATATC...
pathogenic
182,113
Clinically, how would you classify the variant at chromosome 11, position 94456306, gene MRE11 (MRE11 homolog, double strand break repair nuclease): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Hereditary_breast_ovarian_cancer_syndrome', 'Hereditary_cancer-predisposing_syndrome']
GAGATGGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAAACTCCTGAGCTCAAGAGATCCACCTGCCTCGGCCTCCCAAAGTGCTGAAATTACAGGTAAGTCACAATGCCCAGCCTGAAAGACTTTAAAGCATACTGTTTTTTCTCCAAATAGAAGAGCTAATAGTCTTGTTTGTCAGTATAAGTAATTTAAGCATGGCGCTGGGATTCATATTCTAAGCCAAATGATTCTGCAAAGCTGTGAATTACAGCTTGGCAGAGTTTCAGACTCCATTACCTAAGTTCTAAATAGTATGCTGAAAATGAAAAAATATATAATATC...
GAGATGGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAAACTCCTGAGCTCAAGAGATCCACCTGCCTCGGCCTCCCAAAGTGCTGAAATTACAGGTAAGTCACAATGCCCAGCCTGAAAGACTTTAAAGCATACTGTTTTTTCTCCAAATAGAAGAGCTAATAGTCTTGTTTGTCAGTATAAGTAATTTAAGCATGGCGCTGGGATTCATATTCTAAGCCAAATGATTCTGCAAAGCTGTGAATTACAGCTTGGCAGAGTTTCAGACTCCATTACCTAAGTTCTAAATAGTATGCTGAAAATGAAAAAATATATAATATC...
pathogenic
182,114
A genetic alteration at chromosome 11, position 94459446, in gene MRE11 (MRE11 homolog, double strand break repair nuclease)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1']
AGAGGAACAGAGAGCAGTAGCTAAAGGAAAATGGGATCGAGAGTTTTGTTTGTTTCTTAAGCTGAAAGAAATAACAGCATGTTTGTTATGATTCAGTAGAGGAAAAATACAAGAATAACAATATTTTAAAAGATGAGACAGTATGTAATCGTGCCCTAGGTGATAAGTAGCATACCAAAGGTGCTAAGCCATTCACAGAAGAGAAATGAGAGTCAGAGTGGGAACACTGAACAGGCACTATGTGTCAGACAGTATTCTAAGGATTTTACATGGATTAATTCTTCTAATCCTTACAACAACCTTGAAGGAGGGCCTATTAT...
AGAGGAACAGAGAGCAGTAGCTAAAGGAAAATGGGATCGAGAGTTTTGTTTGTTTCTTAAGCTGAAAGAAATAACAGCATGTTTGTTATGATTCAGTAGAGGAAAAATACAAGAATAACAATATTTTAAAAGATGAGACAGTATGTAATCGTGCCCTAGGTGATAAGTAGCATACCAAAGGTGCTAAGCCATTCACAGAAGAGAAATGAGAGTCAGAGTGGGAACACTGAACAGGCACTATGTGTCAGACAGTATTCTAAGGATTTTACATGGATTAATTCTTCTAATCCTTACAACAACCTTGAAGGAGGGCCTATTAT...
pathogenic
182,118
Gene mutation in MRE11 (MRE11 homolog, double strand break repair nuclease) at chromosome 11, position 94459462—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Hereditary_cancer-predisposing_syndrome']
GTAGCTAAAGGAAAATGGGATCGAGAGTTTTGTTTGTTTCTTAAGCTGAAAGAAATAACAGCATGTTTGTTATGATTCAGTAGAGGAAAAATACAAGAATAACAATATTTTAAAAGATGAGACAGTATGTAATCGTGCCCTAGGTGATAAGTAGCATACCAAAGGTGCTAAGCCATTCACAGAAGAGAAATGAGAGTCAGAGTGGGAACACTGAACAGGCACTATGTGTCAGACAGTATTCTAAGGATTTTACATGGATTAATTCTTCTAATCCTTACAACAACCTTGAAGGAGGGCCTATTATCATCACCATTTTATCC...
GTAGCTAAAGGAAAATGGGATCGAGAGTTTTGTTTGTTTCTTAAGCTGAAAGAAATAACAGCATGTTTGTTATGATTCAGTAGAGGAAAAATACAAGAATAACAATATTTTAAAAGATGAGACAGTATGTAATCGTGCCCTAGGTGATAAGTAGCATACCAAAGGTGCTAAGCCATTCACAGAAGAGAAATGAGAGTCAGAGTGGGAACACTGAACAGGCACTATGTGTCAGACAGTATTCTAAGGATTTTACATGGATTAATTCTTCTAATCCTTACAACAACCTTGAAGGAGGGCCTATTATCATCACCATTTTATCC...
pathogenic
182,121
Is the genetic mutation found on chromosome 11 at position 94459466, within the gene MRE11 (MRE11 homolog, double strand break repair nuclease), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
CTAAAGGAAAATGGGATCGAGAGTTTTGTTTGTTTCTTAAGCTGAAAGAAATAACAGCATGTTTGTTATGATTCAGTAGAGGAAAAATACAAGAATAACAATATTTTAAAAGATGAGACAGTATGTAATCGTGCCCTAGGTGATAAGTAGCATACCAAAGGTGCTAAGCCATTCACAGAAGAGAAATGAGAGTCAGAGTGGGAACACTGAACAGGCACTATGTGTCAGACAGTATTCTAAGGATTTTACATGGATTAATTCTTCTAATCCTTACAACAACCTTGAAGGAGGGCCTATTATCATCACCATTTTATCCTCAG...
CTAAAGGAAAATGGGATCGAGAGTTTTGTTTGTTTCTTAAGCTGAAAGAAATAACAGCATGTTTGTTATGATTCAGTAGAGGAAAAATACAAGAATAACAATATTTTAAAAGATGAGACAGTATGTAATCGTGCCCTAGGTGATAAGTAGCATACCAAAGGTGCTAAGCCATTCACAGAAGAGAAATGAGAGTCAGAGTGGGAACACTGAACAGGCACTATGTGTCAGACAGTATTCTAAGGATTTTACATGGATTAATTCTTCTAATCCTTACAACAACCTTGAAGGAGGGCCTATTATCATCACCATTTTATCCTCAG...
pathogenic
182,124
Variant at chromosome position 94459466, chromosome 11, gene MRE11 (MRE11 homolog, double strand break repair nuclease): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
CTAAAGGAAAATGGGATCGAGAGTTTTGTTTGTTTCTTAAGCTGAAAGAAATAACAGCATGTTTGTTATGATTCAGTAGAGGAAAAATACAAGAATAACAATATTTTAAAAGATGAGACAGTATGTAATCGTGCCCTAGGTGATAAGTAGCATACCAAAGGTGCTAAGCCATTCACAGAAGAGAAATGAGAGTCAGAGTGGGAACACTGAACAGGCACTATGTGTCAGACAGTATTCTAAGGATTTTACATGGATTAATTCTTCTAATCCTTACAACAACCTTGAAGGAGGGCCTATTATCATCACCATTTTATCCTCAG...
CTAAAGGAAAATGGGATCGAGAGTTTTGTTTGTTTCTTAAGCTGAAAGAAATAACAGCATGTTTGTTATGATTCAGTAGAGGAAAAATACAAGAATAACAATATTTTAAAAGATGAGACAGTATGTAATCGTGCCCTAGGTGATAAGTAGCATACCAAAGGTGCTAAGCCATTCACAGAAGAGAAATGAGAGTCAGAGTGGGAACACTGAACAGGCACTATGTGTCAGACAGTATTCTAAGGATTTTACATGGATTAATTCTTCTAATCCTTACAACAACCTTGAAGGAGGGCCTATTATCATCACCATTTTATCCTCAG...
pathogenic
182,125
Classify the chromosome 11 variant at position 94460981 affecting gene MRE11 (MRE11 homolog, double strand break repair nuclease) as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1']
ATATTTTCATGTCAATATCTTTTAATTTTGTTTTTTGACAATGTGATATGCAAACATTTATAATTTCTATGTAGTCAAGTCTAGACAGCTTTTCCTGTAATTTTTCCACTGCTTCTTGCTTAGCAGAAATTTTCTAAATGAAATTCAAGATCTCAATCAAAACTTACTAAAAAAATTAAAATGAACAAAAATTACCATCCTACAAGGTTCACTTTAAAGCCCTTTCAAAGGATCTTTAAGAGAAGATACTATCCATGGGGAACAAAACACTTTAGTACCAACCATATGCAAGACTCTGTTCTAGGCATTTTCTACATTTT...
ATATTTTCATGTCAATATCTTTTAATTTTGTTTTTTGACAATGTGATATGCAAACATTTATAATTTCTATGTAGTCAAGTCTAGACAGCTTTTCCTGTAATTTTTCCACTGCTTCTTGCTTAGCAGAAATTTTCTAAATGAAATTCAAGATCTCAATCAAAACTTACTAAAAAAATTAAAATGAACAAAAATTACCATCCTACAAGGTTCACTTTAAAGCCCTTTCAAAGGATCTTTAAGAGAAGATACTATCCATGGGGAACAAAACACTTTAGTACCAACCATATGCAAGACTCTGTTCTAGGCATTTTCTACATTTT...
pathogenic
182,148
Assess the variant on chromosome 11, position 94461009, impacting MRE11 (MRE11 homolog, double strand break repair nuclease): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
TGTTTTTTGACAATGTGATATGCAAACATTTATAATTTCTATGTAGTCAAGTCTAGACAGCTTTTCCTGTAATTTTTCCACTGCTTCTTGCTTAGCAGAAATTTTCTAAATGAAATTCAAGATCTCAATCAAAACTTACTAAAAAAATTAAAATGAACAAAAATTACCATCCTACAAGGTTCACTTTAAAGCCCTTTCAAAGGATCTTTAAGAGAAGATACTATCCATGGGGAACAAAACACTTTAGTACCAACCATATGCAAGACTCTGTTCTAGGCATTTTCTACATTTTCTAATTTAACCTTCATTTTATCATTTCA...
TGTTTTTTGACAATGTGATATGCAAACATTTATAATTTCTATGTAGTCAAGTCTAGACAGCTTTTCCTGTAATTTTTCCACTGCTTCTTGCTTAGCAGAAATTTTCTAAATGAAATTCAAGATCTCAATCAAAACTTACTAAAAAAATTAAAATGAACAAAAATTACCATCCTACAAGGTTCACTTTAAAGCCCTTTCAAAGGATCTTTAAGAGAAGATACTATCCATGGGGAACAAAACACTTTAGTACCAACCATATGCAAGACTCTGTTCTAGGCATTTTCTACATTTTCTAATTTAACCTTCATTTTATCATTTCA...
pathogenic
182,151
Is the genetic mutation found on chromosome 11 at position 94464112, within the gene MRE11 (MRE11 homolog, double strand break repair nuclease), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Hereditary_cancer-predisposing_syndrome']
GACTCTGTCTCAAAAAAATGAAAATAAAAACAAAATCAATGTGCAAAAATCACAGCATTCCTACACCAATAACAGACAAACAGAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCC...
GACTCTGTCTCAAAAAAATGAAAATAAAAACAAAATCAATGTGCAAAAATCACAGCATTCCTACACCAATAACAGACAAACAGAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCC...
pathogenic
182,159
Determine if the mutation at chromosome 11, position 94464115 in gene MRE11 (MRE11 homolog, double strand break repair nuclease) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
TCTGTCTCAAAAAAATGAAAATAAAAACAAAATCAATGTGCAAAAATCACAGCATTCCTACACCAATAACAGACAAACAGAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCAT...
TCTGTCTCAAAAAAATGAAAATAAAAACAAAATCAATGTGCAAAAATCACAGCATTCCTACACCAATAACAGACAAACAGAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCAT...
pathogenic
182,160
For chromosome 11, position 94464194, gene MRE11 (MRE11 homolog, double strand break repair nuclease): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
GAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATT...
GAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATT...
pathogenic
182,168
Assess the variant on chromosome 11, position 94464202, impacting MRE11 (MRE11 homolog, double strand break repair nuclease): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
AATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGAC...
AATCATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGAC...
pathogenic
182,169
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 11, position 94464206, gene MRE11 (MRE11 homolog, double strand break repair nuclease). What disease(s) is it linked to if pathogenic?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Breast_carcinoma']
ATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGACAATC...
ATGAGTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGACAATC...
pathogenic
182,170
Mutation found at chromosome 11 position 94464210, gene MRE11 (MRE11 homolog, double strand break repair nuclease): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1']
GTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGACAATCCTAA...
GTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGACAATCCTAA...
pathogenic
182,172
Is the variant located on chromosome 11 at position 94464210, gene MRE11 (MRE11 homolog, double strand break repair nuclease), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Hereditary_cancer-predisposing_syndrome']
GTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGACAATCCTAA...
GTGAACTCCCATTCACAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGACAATCCTAA...
pathogenic
182,173
Clinical impact (benign or pathogenic) of the variant at chromosome 11, location 94464225, gene MRE11 (MRE11 homolog, double strand break repair nuclease): what disease(s) if pathogenic?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1']
CAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGACAATCCTAAGCAAAAAGATCAAAG...
CAATTGCTTCAAAGAGAATAAAATACCTAGGAATCCAATTTACAAGGATATGAAGGTCCTCTTCAAGGAGAACTACAAACCACTGCTCAACGAAATAAAAGAGGACACAAACAAATGGCAGAACGTTCCATGCTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACTGCCCAAGGTAATTTATAGATTCAATGCCATCCCCATCAAGCTACCAATGACTTTCTTCACAGAATTGGAAAAAACTACTTTAAAGTTCATATGGAACCAAAACAGAGCCCACATTGCCAAGACAATCCTAAGCAAAAAGATCAAAG...
pathogenic
182,174
Clinical significance of chromosome 11, position 94467862, gene MRE11 (MRE11 homolog, double strand break repair nuclease): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Ataxia-telangiectasia-like_disorder']
TGGATGTCCTCAATGTTCTAAGTATGCTGTTCAGGGCCAGGGATACAACCATAAATAAATACAATCTTGGCTGTCAAGAAATTCACAAACTGACTGGGAAGAAAAACATGTAAACAGATCACTGGAAGCAGACTGTGAGTGGTGCTATAAGAGGTATGTACAAAGTTGGATGAGGACACAAAGGAAGAAGCATGTTCTCTGTGGGCAGGTCAAGAAAGGCTTCTTTGAAGACAGAGGCTTTAGGTGGGTGCTGAAGAAGGTATAGAGAAAGGAGGAGAGAAGTATGTCCCACGCAACAGGATCAACATGGACAAAGGTTC...
TGGATGTCCTCAATGTTCTAAGTATGCTGTTCAGGGCCAGGGATACAACCATAAATAAATACAATCTTGGCTGTCAAGAAATTCACAAACTGACTGGGAAGAAAAACATGTAAACAGATCACTGGAAGCAGACTGTGAGTGGTGCTATAAGAGGTATGTACAAAGTTGGATGAGGACACAAAGGAAGAAGCATGTTCTCTGTGGGCAGGTCAAGAAAGGCTTCTTTGAAGACAGAGGCTTTAGGTGGGTGCTGAAGAAGGTATAGAGAAAGGAGGAGAGAAGTATGTCCCACGCAACAGGATCAACATGGACAAAGGTTC...
pathogenic
182,189
Does the variant impacting MRE11 (MRE11 homolog, double strand break repair nuclease) on chromosome 11, position 94470548, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
ATCTCCAGATGGCCAACTTCATAGCTGAACAATTCTAGTTCTTAGAAAGTTCTTGTATTGGAACAAAAACTGCCTTCCTATAACTTGGTCCTGATCTCAAGAACAATACAGAACAAGTGTTTTTGTCCTCAGATTTCTTTCACATCTAAGACTTTATAATCTTGTCCTTTAAACTGTCTGTAACAATGAAGTCCAAAAGAGTTTTCTGCAATAATTTTTTCTATGTGCATATTCAATATGGTTGCCAAAACCATATGTGGATATAGAGTACTTGAAATGTGGCTAGTACAAGTGAGAAACTGAATTTTAAATTTAAATGT...
ATCTCCAGATGGCCAACTTCATAGCTGAACAATTCTAGTTCTTAGAAAGTTCTTGTATTGGAACAAAAACTGCCTTCCTATAACTTGGTCCTGATCTCAAGAACAATACAGAACAAGTGTTTTTGTCCTCAGATTTCTTTCACATCTAAGACTTTATAATCTTGTCCTTTAAACTGTCTGTAACAATGAAGTCCAAAAGAGTTTTCTGCAATAATTTTTTCTATGTGCATATTCAATATGGTTGCCAAAACCATATGTGGATATAGAGTACTTGAAATGTGGCTAGTACAAGTGAGAAACTGAATTTTAAATTTAAATGT...
pathogenic
182,199
Gene MRE11 (MRE11 homolog, double strand break repair nuclease) variant at chromosome position 94470564 on chromosome 11: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
CTTCATAGCTGAACAATTCTAGTTCTTAGAAAGTTCTTGTATTGGAACAAAAACTGCCTTCCTATAACTTGGTCCTGATCTCAAGAACAATACAGAACAAGTGTTTTTGTCCTCAGATTTCTTTCACATCTAAGACTTTATAATCTTGTCCTTTAAACTGTCTGTAACAATGAAGTCCAAAAGAGTTTTCTGCAATAATTTTTTCTATGTGCATATTCAATATGGTTGCCAAAACCATATGTGGATATAGAGTACTTGAAATGTGGCTAGTACAAGTGAGAAACTGAATTTTAAATTTAAATGTAAATAATTAAATGTAA...
CTTCATAGCTGAACAATTCTAGTTCTTAGAAAGTTCTTGTATTGGAACAAAAACTGCCTTCCTATAACTTGGTCCTGATCTCAAGAACAATACAGAACAAGTGTTTTTGTCCTCAGATTTCTTTCACATCTAAGACTTTATAATCTTGTCCTTTAAACTGTCTGTAACAATGAAGTCCAAAAGAGTTTTCTGCAATAATTTTTTCTATGTGCATATTCAATATGGTTGCCAAAACCATATGTGGATATAGAGTACTTGAAATGTGGCTAGTACAAGTGAGAAACTGAATTTTAAATTTAAATGTAAATAATTAAATGTAA...
pathogenic
182,202
Does the genetic variant at chromosome 11, position 94471596, impacting gene MRE11 (MRE11 homolog, double strand break repair nuclease), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Hereditary_cancer-predisposing_syndrome']
AATCTATGTTTGAGTTTCTAGAGTCAATCATCTTGAAACAAGCGTACACTTTTGGTTACGTGAGCTACACACTGCTCAAAAAGCTGTGACACTGAATGAGTCACCTTATCTAAGGTTCAGTTCCTCTAAACTATAGATGGTAGAAACTACTCACATATAGTATTGTTGGCTAGATTAAATGCTGTCAACAGTGCACATCACATACAGTAAATCAGTAAGTATCACTGGTCATAATTATTATCATTGTTACTATGTTACCTGATTTTTCATGAAAAGAAAACATAGTAGGACAGCTGACACAGAGTTAAGAACTGAGCGTC...
AATCTATGTTTGAGTTTCTAGAGTCAATCATCTTGAAACAAGCGTACACTTTTGGTTACGTGAGCTACACACTGCTCAAAAAGCTGTGACACTGAATGAGTCACCTTATCTAAGGTTCAGTTCCTCTAAACTATAGATGGTAGAAACTACTCACATATAGTATTGTTGGCTAGATTAAATGCTGTCAACAGTGCACATCACATACAGTAAATCAGTAAGTATCACTGGTCATAATTATTATCATTGTTACTATGTTACCTGATTTTTCATGAAAAGAAAACATAGTAGGACAGCTGACACAGAGTTAAGAACTGAGCGTC...
pathogenic
182,219
Variant on chromosome 11, at position 94471597, affecting MRE11 (MRE11 homolog, double strand break repair nuclease): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
ATCTATGTTTGAGTTTCTAGAGTCAATCATCTTGAAACAAGCGTACACTTTTGGTTACGTGAGCTACACACTGCTCAAAAAGCTGTGACACTGAATGAGTCACCTTATCTAAGGTTCAGTTCCTCTAAACTATAGATGGTAGAAACTACTCACATATAGTATTGTTGGCTAGATTAAATGCTGTCAACAGTGCACATCACATACAGTAAATCAGTAAGTATCACTGGTCATAATTATTATCATTGTTACTATGTTACCTGATTTTTCATGAAAAGAAAACATAGTAGGACAGCTGACACAGAGTTAAGAACTGAGCGTCA...
ATCTATGTTTGAGTTTCTAGAGTCAATCATCTTGAAACAAGCGTACACTTTTGGTTACGTGAGCTACACACTGCTCAAAAAGCTGTGACACTGAATGAGTCACCTTATCTAAGGTTCAGTTCCTCTAAACTATAGATGGTAGAAACTACTCACATATAGTATTGTTGGCTAGATTAAATGCTGTCAACAGTGCACATCACATACAGTAAATCAGTAAGTATCACTGGTCATAATTATTATCATTGTTACTATGTTACCTGATTTTTCATGAAAAGAAAACATAGTAGGACAGCTGACACAGAGTTAAGAACTGAGCGTCA...
pathogenic
182,220
Considering the genetic mutation at chromosome 11, position 94471634, impacting MRE11 (MRE11 homolog, double strand break repair nuclease): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
CAAGCGTACACTTTTGGTTACGTGAGCTACACACTGCTCAAAAAGCTGTGACACTGAATGAGTCACCTTATCTAAGGTTCAGTTCCTCTAAACTATAGATGGTAGAAACTACTCACATATAGTATTGTTGGCTAGATTAAATGCTGTCAACAGTGCACATCACATACAGTAAATCAGTAAGTATCACTGGTCATAATTATTATCATTGTTACTATGTTACCTGATTTTTCATGAAAAGAAAACATAGTAGGACAGCTGACACAGAGTTAAGAACTGAGCGTCAGCAAGTGATGCTAATTAAGCTGTCAAACCACATATTA...
CAAGCGTACACTTTTGGTTACGTGAGCTACACACTGCTCAAAAAGCTGTGACACTGAATGAGTCACCTTATCTAAGGTTCAGTTCCTCTAAACTATAGATGGTAGAAACTACTCACATATAGTATTGTTGGCTAGATTAAATGCTGTCAACAGTGCACATCACATACAGTAAATCAGTAAGTATCACTGGTCATAATTATTATCATTGTTACTATGTTACCTGATTTTTCATGAAAAGAAAACATAGTAGGACAGCTGACACAGAGTTAAGAACTGAGCGTCAGCAAGTGATGCTAATTAAGCTGTCAAACCACATATTA...
pathogenic
182,226
Is chromosome 11, position 94471679, gene MRE11 (MRE11 homolog, double strand break repair nuclease) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Hereditary_cancer-predisposing_syndrome']
CTGTGACACTGAATGAGTCACCTTATCTAAGGTTCAGTTCCTCTAAACTATAGATGGTAGAAACTACTCACATATAGTATTGTTGGCTAGATTAAATGCTGTCAACAGTGCACATCACATACAGTAAATCAGTAAGTATCACTGGTCATAATTATTATCATTGTTACTATGTTACCTGATTTTTCATGAAAAGAAAACATAGTAGGACAGCTGACACAGAGTTAAGAACTGAGCGTCAGCAAGTGATGCTAATTAAGCTGTCAAACCACATATTATTAAATGCATTAATCCACCCAACCTTAGTAGTGGCTGAAATTTTC...
CTGTGACACTGAATGAGTCACCTTATCTAAGGTTCAGTTCCTCTAAACTATAGATGGTAGAAACTACTCACATATAGTATTGTTGGCTAGATTAAATGCTGTCAACAGTGCACATCACATACAGTAAATCAGTAAGTATCACTGGTCATAATTATTATCATTGTTACTATGTTACCTGATTTTTCATGAAAAGAAAACATAGTAGGACAGCTGACACAGAGTTAAGAACTGAGCGTCAGCAAGTGATGCTAATTAAGCTGTCAAACCACATATTATTAAATGCATTAATCCACCCAACCTTAGTAGTGGCTGAAATTTTC...
pathogenic
182,230
Assess the variant on chromosome 11, position 94478767, impacting MRE11 (MRE11 homolog, double strand break repair nuclease): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
TTTTCTTTTCTTTTCTTTTCTAAACACAGTCTTGCTCCATTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTTCACCTCCTGGGTTCAAGGGATTCTTGTGCCTCAGCCTCCTGAGTTGCTGGGATTACAGCATGCACCACCACGTCTGGCTAATTTTTGCACTTTTAGTAGAGATGGGGTTTTGCCACGTTGGACAGGCTGGTCTTGAACTCCGGACCTCAAGTGATCTACCTGCCTTGGCCTCCCAAAGTGCTGAAATTACAGGCGTGTGCCAGCACGCCTGGCCTGTTCCAGGTTCTTGATAA...
TTTTCTTTTCTTTTCTTTTCTAAACACAGTCTTGCTCCATTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTTCACCTCCTGGGTTCAAGGGATTCTTGTGCCTCAGCCTCCTGAGTTGCTGGGATTACAGCATGCACCACCACGTCTGGCTAATTTTTGCACTTTTAGTAGAGATGGGGTTTTGCCACGTTGGACAGGCTGGTCTTGAACTCCGGACCTCAAGTGATCTACCTGCCTTGGCCTCCCAAAGTGCTGAAATTACAGGCGTGTGCCAGCACGCCTGGCCTGTTCCAGGTTCTTGATAA...
pathogenic
182,258
Does the chromosome 11 mutation at position 94478782 within gene MRE11 (MRE11 homolog, double strand break repair nuclease) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Hereditary_cancer-predisposing_syndrome']
TTTTCTAAACACAGTCTTGCTCCATTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTTCACCTCCTGGGTTCAAGGGATTCTTGTGCCTCAGCCTCCTGAGTTGCTGGGATTACAGCATGCACCACCACGTCTGGCTAATTTTTGCACTTTTAGTAGAGATGGGGTTTTGCCACGTTGGACAGGCTGGTCTTGAACTCCGGACCTCAAGTGATCTACCTGCCTTGGCCTCCCAAAGTGCTGAAATTACAGGCGTGTGCCAGCACGCCTGGCCTGTTCCAGGTTCTTGATAACAGTAGTTAGTTGCA...
TTTTCTAAACACAGTCTTGCTCCATTGCCCAGGCTGGAGTGCAGTGGTGTGATCTCAGCTCACTGCAACCTTCACCTCCTGGGTTCAAGGGATTCTTGTGCCTCAGCCTCCTGAGTTGCTGGGATTACAGCATGCACCACCACGTCTGGCTAATTTTTGCACTTTTAGTAGAGATGGGGTTTTGCCACGTTGGACAGGCTGGTCTTGAACTCCGGACCTCAAGTGATCTACCTGCCTTGGCCTCCCAAAGTGCTGAAATTACAGGCGTGTGCCAGCACGCCTGGCCTGTTCCAGGTTCTTGATAACAGTAGTTAGTTGCA...
pathogenic
182,262
Regarding the variant found on chromosome 11 at position 94479671 in gene MRE11 (MRE11 homolog, double strand break repair nuclease): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Hereditary_cancer-predisposing_syndrome']
GAATGTAGAACATGTAACTGGAGACAAAAAAGTCAAGGCACACAAAGCCCAAGGCATTAGAAGATTAATCTACTTGAGTGTTGAAACACTAAAAACACTGGCAAAATTGAAGGTAGGTAAGTAGGTAAAAAGTCTGAGAGAAAAAGCAATGCGGTTTAGCCAGATGGCAGAAGCTTAAAGGGAACAGTGTGTTTGCAGGCAGAAAAGGAAGCAGTGGGTGGAGCAAGGAGAACAGTGATCCCCGCTTCTTTCCAAAAGCCCAGGGGTAAGAGAACTGCATGGGACACAGGAACCTCAGGGGACAGCTGGGCTTCACTGAA...
GAATGTAGAACATGTAACTGGAGACAAAAAAGTCAAGGCACACAAAGCCCAAGGCATTAGAAGATTAATCTACTTGAGTGTTGAAACACTAAAAACACTGGCAAAATTGAAGGTAGGTAAGTAGGTAAAAAGTCTGAGAGAAAAAGCAATGCGGTTTAGCCAGATGGCAGAAGCTTAAAGGGAACAGTGTGTTTGCAGGCAGAAAAGGAAGCAGTGGGTGGAGCAAGGAGAACAGTGATCCCCGCTTCTTTCCAAAAGCCCAGGGGTAAGAGAACTGCATGGGACACAGGAACCTCAGGGGACAGCTGGGCTTCACTGAA...
pathogenic
182,279
Chromosome 11, position 94479764, gene MRE11 (MRE11 homolog, double strand break repair nuclease): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
benign
AACACTGGCAAAATTGAAGGTAGGTAAGTAGGTAAAAAGTCTGAGAGAAAAAGCAATGCGGTTTAGCCAGATGGCAGAAGCTTAAAGGGAACAGTGTGTTTGCAGGCAGAAAAGGAAGCAGTGGGTGGAGCAAGGAGAACAGTGATCCCCGCTTCTTTCCAAAAGCCCAGGGGTAAGAGAACTGCATGGGACACAGGAACCTCAGGGGACAGCTGGGCTTCACTGAAGGTTAGAAAGTGGAGGTAACATTCAGAGAAGAGACTGATAATAATGAGGAATCTGATAATTATAAAAAGAGTTCTAGAGTTTATAATGAAGAG...
AACACTGGCAAAATTGAAGGTAGGTAAGTAGGTAAAAAGTCTGAGAGAAAAAGCAATGCGGTTTAGCCAGATGGCAGAAGCTTAAAGGGAACAGTGTGTTTGCAGGCAGAAAAGGAAGCAGTGGGTGGAGCAAGGAGAACAGTGATCCCCGCTTCTTTCCAAAAGCCCAGGGGTAAGAGAACTGCATGGGACACAGGAACCTCAGGGGACAGCTGGGCTTCACTGAAGGTTAGAAAGTGGAGGTAACATTCAGAGAAGAGACTGATAATAATGAGGAATCTGATAATTATAAAAAGAGTTCTAGAGTTTATAATGAAGAG...
benign
182,291
Variant in MRE11 (MRE11 homolog, double strand break repair nuclease), chromosome 11, position 94479764—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
benign
AACACTGGCAAAATTGAAGGTAGGTAAGTAGGTAAAAAGTCTGAGAGAAAAAGCAATGCGGTTTAGCCAGATGGCAGAAGCTTAAAGGGAACAGTGTGTTTGCAGGCAGAAAAGGAAGCAGTGGGTGGAGCAAGGAGAACAGTGATCCCCGCTTCTTTCCAAAAGCCCAGGGGTAAGAGAACTGCATGGGACACAGGAACCTCAGGGGACAGCTGGGCTTCACTGAAGGTTAGAAAGTGGAGGTAACATTCAGAGAAGAGACTGATAATAATGAGGAATCTGATAATTATAAAAAGAGTTCTAGAGTTTATAATGAAGAG...
AACACTGGCAAAATTGAAGGTAGGTAAGTAGGTAAAAAGTCTGAGAGAAAAAGCAATGCGGTTTAGCCAGATGGCAGAAGCTTAAAGGGAACAGTGTGTTTGCAGGCAGAAAAGGAAGCAGTGGGTGGAGCAAGGAGAACAGTGATCCCCGCTTCTTTCCAAAAGCCCAGGGGTAAGAGAACTGCATGGGACACAGGAACCTCAGGGGACAGCTGGGCTTCACTGAAGGTTAGAAAGTGGAGGTAACATTCAGAGAAGAGACTGATAATAATGAGGAATCTGATAATTATAAAAAGAGTTCTAGAGTTTATAATGAAGAG...
benign
182,292
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 11, position 94479764, gene MRE11 (MRE11 homolog, double strand break repair nuclease). What disease(s) is it linked to if pathogenic?
benign
AACACTGGCAAAATTGAAGGTAGGTAAGTAGGTAAAAAGTCTGAGAGAAAAAGCAATGCGGTTTAGCCAGATGGCAGAAGCTTAAAGGGAACAGTGTGTTTGCAGGCAGAAAAGGAAGCAGTGGGTGGAGCAAGGAGAACAGTGATCCCCGCTTCTTTCCAAAAGCCCAGGGGTAAGAGAACTGCATGGGACACAGGAACCTCAGGGGACAGCTGGGCTTCACTGAAGGTTAGAAAGTGGAGGTAACATTCAGAGAAGAGACTGATAATAATGAGGAATCTGATAATTATAAAAAGAGTTCTAGAGTTTATAATGAAGAG...
AACACTGGCAAAATTGAAGGTAGGTAAGTAGGTAAAAAGTCTGAGAGAAAAAGCAATGCGGTTTAGCCAGATGGCAGAAGCTTAAAGGGAACAGTGTGTTTGCAGGCAGAAAAGGAAGCAGTGGGTGGAGCAAGGAGAACAGTGATCCCCGCTTCTTTCCAAAAGCCCAGGGGTAAGAGAACTGCATGGGACACAGGAACCTCAGGGGACAGCTGGGCTTCACTGAAGGTTAGAAAGTGGAGGTAACATTCAGAGAAGAGACTGATAATAATGAGGAATCTGATAATTATAAAAAGAGTTCTAGAGTTTATAATGAAGAG...
benign
182,293
Chromosome 11, position 94485939, gene MRE11 (MRE11 homolog, double strand break repair nuclease): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Ataxia-telangiectasia-like_disorder_1', 'Hereditary_cancer-predisposing_syndrome']
TGTCTATTCTCATGGGTTAGTATGTACACATATTTTTCTTAGCTCTGTCCAGTGAGAGCCTAGAAGCAACAATACAATAGTAATGTGCACATGTAACATCCAGATCTTGGTTTCCAAATACCATTCTCCAAAAGGAACCAGGGTTCCTTGAAGAAATGGCTGAGTCTGAAGACAAGAAAGACAAAGTAAAAAATCAGAAGAAAAGGTGGGATATATCAAAAGGATACAGGAGCCAATCTCAAAAGGAGCCCAATGGCTAAAGCTGGAACAATTTAAGCCACAAGTAAATTATGATAGTAATAAATTATAACCCAAAGGAA...
TGTCTATTCTCATGGGTTAGTATGTACACATATTTTTCTTAGCTCTGTCCAGTGAGAGCCTAGAAGCAACAATACAATAGTAATGTGCACATGTAACATCCAGATCTTGGTTTCCAAATACCATTCTCCAAAAGGAACCAGGGTTCCTTGAAGAAATGGCTGAGTCTGAAGACAAGAAAGACAAAGTAAAAAATCAGAAGAAAAGGTGGGATATATCAAAAGGATACAGGAGCCAATCTCAAAAGGAGCCCAATGGCTAAAGCTGGAACAATTTAAGCCACAAGTAAATTATGATAGTAATAAATTATAACCCAAAGGAA...
pathogenic
182,300
For chromosome 11, position 94486070, gene MRE11 (MRE11 homolog, double strand break repair nuclease): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Ataxia-telangiectasia-like_disorder', 'Hereditary_cancer-predisposing_syndrome']
AAGGAACCAGGGTTCCTTGAAGAAATGGCTGAGTCTGAAGACAAGAAAGACAAAGTAAAAAATCAGAAGAAAAGGTGGGATATATCAAAAGGATACAGGAGCCAATCTCAAAAGGAGCCCAATGGCTAAAGCTGGAACAATTTAAGCCACAAGTAAATTATGATAGTAATAAATTATAACCCAAAGGAAAAAAAAATGGGTTTCTACTGATATAGACAATTGAATAAACAAATGTGGGACAAGGGACAAATCTTCCTTACAAAAGAATCCCAATTAATACATGTAGAAAGAATATAGGAAATGGAAAATCACAATTAGAA...
AAGGAACCAGGGTTCCTTGAAGAAATGGCTGAGTCTGAAGACAAGAAAGACAAAGTAAAAAATCAGAAGAAAAGGTGGGATATATCAAAAGGATACAGGAGCCAATCTCAAAAGGAGCCCAATGGCTAAAGCTGGAACAATTTAAGCCACAAGTAAATTATGATAGTAATAAATTATAACCCAAAGGAAAAAAAAATGGGTTTCTACTGATATAGACAATTGAATAAACAAATGTGGGACAAGGGACAAATCTTCCTTACAAAAGAATCCCAATTAATACATGTAGAAAGAATATAGGAAATGGAAAATCACAATTAGAA...
pathogenic
182,319
Variant in gene MRE11 (MRE11 homolog, double strand break repair nuclease), located at chromosome 11 position 94490976: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
CCCTGAACCTAAAATAAAAGAAAGAATCCAGCCATTGCCTCACTTAATTAAGAAATTTAAAATATGTATACCCACTGCTTTCTGATTCTTTCTAAGCACTAAGATACAGCATGAACAAACAAAAGATTTCCACTCTCATGGAGTTTTCCTTCTAGTGAAGACAACAGACAATAAACAAGTAAATAATTCAATAAATTATTTCAGATAGTGCTATTAAAAATATGCTATGAAAAAAAGCAGAGTAATGTGATAAAACAGTGCTTGGAAGTATCAGGGAAGACGTCTCCAAAAAGGTAAGACTTGAACTCTCAGAAGTCGGC...
CCCTGAACCTAAAATAAAAGAAAGAATCCAGCCATTGCCTCACTTAATTAAGAAATTTAAAATATGTATACCCACTGCTTTCTGATTCTTTCTAAGCACTAAGATACAGCATGAACAAACAAAAGATTTCCACTCTCATGGAGTTTTCCTTCTAGTGAAGACAACAGACAATAAACAAGTAAATAATTCAATAAATTATTTCAGATAGTGCTATTAAAAATATGCTATGAAAAAAAGCAGAGTAATGTGATAAAACAGTGCTTGGAAGTATCAGGGAAGACGTCTCCAAAAAGGTAAGACTTGAACTCTCAGAAGTCGGC...
benign
182,334
Variant in gene CEP57 (centrosomal protein 57), located at chromosome 11 position 95827811: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Mosaic_variegated_aneuploidy_syndrome_1', 'Mosaic_variegated_aneuploidy_syndrome_2']
TTTTTGTATTTTTTTAGTAAAGACAGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAAATCCTGACCTTAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTCTGTAATCCCACTGTAATCCCAGTGGCTGAGCCACTGCGCCCAGCCTGCTTTTGACTTTTACGACATCGACCCTTCTATGATACATCACTGAAACTAAAACAAATGGTGGAAGAATTGGTATCTCATAGAAACATTTTTAGAGAAATGAAAAAGCAGAAAAGTCAAGACAAATTATAGTGTATTTCTGTAAAGTTACACAGAATGTGCTAG...
TTTTTGTATTTTTTTAGTAAAGACAGGGTTTCTCCATGTTGGCCAGGCTGGTCTCGAAATCCTGACCTTAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGGGATTCTGTAATCCCACTGTAATCCCAGTGGCTGAGCCACTGCGCCCAGCCTGCTTTTGACTTTTACGACATCGACCCTTCTATGATACATCACTGAAACTAAAACAAATGGTGGAAGAATTGGTATCTCATAGAAACATTTTTAGAGAAATGAAAAAGCAGAAAAGTCAAGACAAATTATAGTGTATTTCTGTAAAGTTACACAGAATGTGCTAG...
pathogenic
182,396
Clinical impact (benign or pathogenic) of the variant at chromosome 11, location 95835336, gene MTMR2 (myotubularin related protein 2): what disease(s) if pathogenic?
pathogenic; ['Charcot-Marie-Tooth_disease_type_4', 'Inborn_genetic_diseases']
TGGTCTCTAAATTTTGTAACCCTAATCAAAAAGGGAAAAAATTACACCTGCACAACCAATAGACATACAAAGTTATGAAACATGTAACTGTCAATTCAAATATTTAAAAGTTTTGCTTGTGTAAATATATAAAAAGGGCTAGTATTCCTCCTCCCTCCCTCCCACACACACCAGTGGTATATATTAAATGCCCAAGTGCATGTACTCCATATTGGAGACTTCTGCAGAAGGTGAGGGGAACCACTGGAAGGTTCTCAGCAGAGAAGTGGTAGGGTTGCACTTAGATTTCCCTGGCTTTTGATTTGAATTTGAAGTGGATG...
TGGTCTCTAAATTTTGTAACCCTAATCAAAAAGGGAAAAAATTACACCTGCACAACCAATAGACATACAAAGTTATGAAACATGTAACTGTCAATTCAAATATTTAAAAGTTTTGCTTGTGTAAATATATAAAAAGGGCTAGTATTCCTCCTCCCTCCCTCCCACACACACCAGTGGTATATATTAAATGCCCAAGTGCATGTACTCCATATTGGAGACTTCTGCAGAAGGTGAGGGGAACCACTGGAAGGTTCTCAGCAGAGAAGTGGTAGGGTTGCACTTAGATTTCCCTGGCTTTTGATTTGAATTTGAAGTGGATG...
pathogenic
182,424