question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Does the genetic variant at chromosome 15, position 27926154, impacting gene OCA2 (OCA2 melanosomal transmembrane protein), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['OCA2-related_disorder', 'Oculocutaneous_albinism', 'SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
GAGTAGAGACTGCCTGCCCCACTGCTTGTTTTGGTCAGCTTTGTCGAAGATCAGATGGTCATAGGTGTACAGCCTTATTTCTGGGCTCTCTGTTCTGTTCCATTGGTCTATGTGACATACCTAACTTTGACTTAATTTTTTTCAATATTTCTAAGCTATGCAGTTCATCTGTGTTTTTTCAAATTATCACAAATCTCCAAAAAAAATTCCCATACATTTATTGAAAAAGATCTCCATATAAGTAGACCCATGCAGTTCAAATCCATGTTGTTCAAGGGTCAATTGTATGTCTTTTTTTTATCATTTTTCTTTTTTCTCTT...
GAGTAGAGACTGCCTGCCCCACTGCTTGTTTTGGTCAGCTTTGTCGAAGATCAGATGGTCATAGGTGTACAGCCTTATTTCTGGGCTCTCTGTTCTGTTCCATTGGTCTATGTGACATACCTAACTTTGACTTAATTTTTTTCAATATTTCTAAGCTATGCAGTTCATCTGTGTTTTTTCAAATTATCACAAATCTCCAAAAAAAATTCCCATACATTTATTGAAAAAGATCTCCATATAAGTAGACCCATGCAGTTCAAATCCATGTTGTTCAAGGGTCAATTGTATGTCTTTTTTTTATCATTTTTCTTTTTTCTCTT...
pathogenic
228,716
Is the chromosome 15, position 27951820 variant in OCA2 (OCA2 melanosomal transmembrane protein) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Oculocutaneous_albinism', 'SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES']
GTATCCATTTTGCCCTTGTTCTATCAGAAAAGTTCTTATAACTCTAAGGAAACTGTATTCCATTAAAATATATGCCAATCAAACTTTTCTCCTAGTCAACCTAACCTATCTTGATAAATATGCAGTATCTGGATCCCCAGATAAAATCACCTGAACACAAGCCCTAACTAAAAACAAAACAGGATTTAAAAGCAGAAAATAAACATGTCCATCATTCACAGATGTAACAACCACACAAAAGGAGATGAGACATTTTGTAAAAAAAACGTAGACTTGCAGGCTAAAAGTTTCATAGTAACCAAGATTTTTTAAGTCCATAT...
GTATCCATTTTGCCCTTGTTCTATCAGAAAAGTTCTTATAACTCTAAGGAAACTGTATTCCATTAAAATATATGCCAATCAAACTTTTCTCCTAGTCAACCTAACCTATCTTGATAAATATGCAGTATCTGGATCCCCAGATAAAATCACCTGAACACAAGCCCTAACTAAAAACAAAACAGGATTTAAAAGCAGAAAATAAACATGTCCATCATTCACAGATGTAACAACCACACAAAAGGAGATGAGACATTTTGTAAAAAAAACGTAGACTTGCAGGCTAAAAGTTTCATAGTAACCAAGATTTTTTAAGTCCATAT...
pathogenic
228,722
Chromosome 15, position 27955158, gene OCA2 (OCA2 melanosomal transmembrane protein): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
CAGGTGGATCTCGATATCTACCATCATAGTGATCTATAGCTATCTGGATTTGGACAGATATAGACATATAGATATATAGATATAGACACACAGAGGTAGAGCTAGAGCTACAAAGAGATTCTCTCTCTTGCTTCCTCTGGTCACAAAGGTAAAGCTGCTGCCATCAAAAACACATGCAAGGCCCTCTGTGTCACAACAGCTGACACAGCCCCTCCTCTATGTGCAGTGGGGCCACTGGTGAGCATCTGCCCCTCCCTGCCCACCGTGAAGGCTCATGGCTGGGCCAGCCCCTTCTCATCTTCCCTGTCGCCTCTCTGGGG...
CAGGTGGATCTCGATATCTACCATCATAGTGATCTATAGCTATCTGGATTTGGACAGATATAGACATATAGATATATAGATATAGACACACAGAGGTAGAGCTAGAGCTACAAAGAGATTCTCTCTCTTGCTTCCTCTGGTCACAAAGGTAAAGCTGCTGCCATCAAAAACACATGCAAGGCCCTCTGTGTCACAACAGCTGACACAGCCCCTCCTCTATGTGCAGTGGGGCCACTGGTGAGCATCTGCCCCTCCCTGCCCACCGTGAAGGCTCATGGCTGGGCCAGCCCCTTCTCATCTTCCCTGTCGCCTCTCTGGGG...
pathogenic
228,728
Does the variant impacting OCA2 (OCA2 melanosomal transmembrane protein) on chromosome 15, position 27955158, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES']
CAGGTGGATCTCGATATCTACCATCATAGTGATCTATAGCTATCTGGATTTGGACAGATATAGACATATAGATATATAGATATAGACACACAGAGGTAGAGCTAGAGCTACAAAGAGATTCTCTCTCTTGCTTCCTCTGGTCACAAAGGTAAAGCTGCTGCCATCAAAAACACATGCAAGGCCCTCTGTGTCACAACAGCTGACACAGCCCCTCCTCTATGTGCAGTGGGGCCACTGGTGAGCATCTGCCCCTCCCTGCCCACCGTGAAGGCTCATGGCTGGGCCAGCCCCTTCTCATCTTCCCTGTCGCCTCTCTGGGG...
CAGGTGGATCTCGATATCTACCATCATAGTGATCTATAGCTATCTGGATTTGGACAGATATAGACATATAGATATATAGATATAGACACACAGAGGTAGAGCTAGAGCTACAAAGAGATTCTCTCTCTTGCTTCCTCTGGTCACAAAGGTAAAGCTGCTGCCATCAAAAACACATGCAAGGCCCTCTGTGTCACAACAGCTGACACAGCCCCTCCTCTATGTGCAGTGGGGCCACTGGTGAGCATCTGCCCCTCCCTGCCCACCGTGAAGGCTCATGGCTGGGCCAGCCCCTTCTCATCTTCCCTGTCGCCTCTCTGGGG...
pathogenic
228,729
Chromosome 15, position 27955191, gene OCA2 (OCA2 melanosomal transmembrane protein): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
CTATAGCTATCTGGATTTGGACAGATATAGACATATAGATATATAGATATAGACACACAGAGGTAGAGCTAGAGCTACAAAGAGATTCTCTCTCTTGCTTCCTCTGGTCACAAAGGTAAAGCTGCTGCCATCAAAAACACATGCAAGGCCCTCTGTGTCACAACAGCTGACACAGCCCCTCCTCTATGTGCAGTGGGGCCACTGGTGAGCATCTGCCCCTCCCTGCCCACCGTGAAGGCTCATGGCTGGGCCAGCCCCTTCTCATCTTCCCTGTCGCCTCTCTGGGGAAGGCCGATTTTCCTACATGATTCTGTGCTGAA...
CTATAGCTATCTGGATTTGGACAGATATAGACATATAGATATATAGATATAGACACACAGAGGTAGAGCTAGAGCTACAAAGAGATTCTCTCTCTTGCTTCCTCTGGTCACAAAGGTAAAGCTGCTGCCATCAAAAACACATGCAAGGCCCTCTGTGTCACAACAGCTGACACAGCCCCTCCTCTATGTGCAGTGGGGCCACTGGTGAGCATCTGCCCCTCCCTGCCCACCGTGAAGGCTCATGGCTGGGCCAGCCCCTTCTCATCTTCCCTGTCGCCTCTCTGGGGAAGGCCGATTTTCCTACATGATTCTGTGCTGAA...
pathogenic
228,731
Gene OCA2 (OCA2 melanosomal transmembrane protein) variant at chromosome position 27966770 on chromosome 15: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['OCA2-related_disorder']
TGCTAAACTCAGATCTCTTGAGTGGGGCTTGGGAATCTGCAGTTTTACCCACCACTCCAAATTTGGAGCCCTCTAAGCCCCACAGTGGCACAGAGCAATCACCCCACCTTGCACTGCTGGTCTTAGCCCGGCCATAGGGTTCCTGCATCACCAGGTGTGTCCACTTCCAACCATCACTCCCCACTTCCCTCGAAGCTTTTCTCTGTTCCTTACTCAGGAACGGTGAGGAATTCATTACAGAGATTATTTTCTGTGTGTCTAAATCTGTGTATCCCAAATTCATCTCAAGATTAGACTCTTCAGGACAGCTTACTAACAAC...
TGCTAAACTCAGATCTCTTGAGTGGGGCTTGGGAATCTGCAGTTTTACCCACCACTCCAAATTTGGAGCCCTCTAAGCCCCACAGTGGCACAGAGCAATCACCCCACCTTGCACTGCTGGTCTTAGCCCGGCCATAGGGTTCCTGCATCACCAGGTGTGTCCACTTCCAACCATCACTCCCCACTTCCCTCGAAGCTTTTCTCTGTTCCTTACTCAGGAACGGTGAGGAATTCATTACAGAGATTATTTTCTGTGTGTCTAAATCTGTGTATCCCAAATTCATCTCAAGATTAGACTCTTCAGGACAGCTTACTAACAAC...
pathogenic
228,744
Chromosome 15, position 27985179, gene OCA2 (OCA2 melanosomal transmembrane protein): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
GATCAGAATGAGTATGAAGTCAATTCAAGCCAGTTAACTCTAGGATTGAAGGACCAGTCACCTAACATCCCAGTCTTGAGATGCCCAGTAGCACTTACTGTGAAGAGGTGGCGTGATGATCTTGATTTCTAACAAAGGCGTCCATGTGGGGTAGAGCTCTAACTAAGTGGAGGTGTGCGTTTACTGGAAGCAACCCTAGCATGCTGGTACGTACCATCTTCCTCAGCTCTTGGTTGGAAACAATAATGACATTTGGAGGGTCCCCGATGGCAGTGGCAGCTCCTCCAATGTTTGTGAAGATCACTTCTGCAATCAGGACT...
GATCAGAATGAGTATGAAGTCAATTCAAGCCAGTTAACTCTAGGATTGAAGGACCAGTCACCTAACATCCCAGTCTTGAGATGCCCAGTAGCACTTACTGTGAAGAGGTGGCGTGATGATCTTGATTTCTAACAAAGGCGTCCATGTGGGGTAGAGCTCTAACTAAGTGGAGGTGTGCGTTTACTGGAAGCAACCCTAGCATGCTGGTACGTACCATCTTCCTCAGCTCTTGGTTGGAAACAATAATGACATTTGGAGGGTCCCCGATGGCAGTGGCAGCTCCTCCAATGTTTGTGAAGATCACTTCTGCAATCAGGACT...
pathogenic
228,763
Mutation found at chromosome 15 position 27990588, gene OCA2 (OCA2 melanosomal transmembrane protein): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
CCAGGAGGGAGGCTCAGGAGAAAGCATGCCTGCCCACACCGTGATCTCGGACTTGCAGCCTCCAGAGCTGTGAGAAAATACATTTATATTATTTAAGCCACACGGTCTGTGGTACTTTGTTACATAGTCCTAGCAAACTAATATAGCATTCCTTTTTTAAAAAAGGCGTATCTCAGGGATATCTGGTACACTTCCTCTCTTCTATCCAGATGCCCAAACTCTGTATACGTCTCAGGCCCGACACAAGTATTAGTTACTCTGTGAAGCCAGGGTTAGAGCACTGGCCTGCCTCCCTGCGCACCACCCACAGAGGATGGCGG...
CCAGGAGGGAGGCTCAGGAGAAAGCATGCCTGCCCACACCGTGATCTCGGACTTGCAGCCTCCAGAGCTGTGAGAAAATACATTTATATTATTTAAGCCACACGGTCTGTGGTACTTTGTTACATAGTCCTAGCAAACTAATATAGCATTCCTTTTTTAAAAAAGGCGTATCTCAGGGATATCTGGTACACTTCCTCTCTTCTATCCAGATGCCCAAACTCTGTATACGTCTCAGGCCCGACACAAGTATTAGTTACTCTGTGAAGCCAGGGTTAGAGCACTGGCCTGCCTCCCTGCGCACCACCCACAGAGGATGGCGG...
pathogenic
228,770
Does the variant on chromosome 15 at location 27990629 affecting gene OCA2 (OCA2 melanosomal transmembrane protein) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
TGATCTCGGACTTGCAGCCTCCAGAGCTGTGAGAAAATACATTTATATTATTTAAGCCACACGGTCTGTGGTACTTTGTTACATAGTCCTAGCAAACTAATATAGCATTCCTTTTTTAAAAAAGGCGTATCTCAGGGATATCTGGTACACTTCCTCTCTTCTATCCAGATGCCCAAACTCTGTATACGTCTCAGGCCCGACACAAGTATTAGTTACTCTGTGAAGCCAGGGTTAGAGCACTGGCCTGCCTCCCTGCGCACCACCCACAGAGGATGGCGGCACGGTTTCCATCAGGTCACATAGCTGGGCCCTCCGTTATG...
TGATCTCGGACTTGCAGCCTCCAGAGCTGTGAGAAAATACATTTATATTATTTAAGCCACACGGTCTGTGGTACTTTGTTACATAGTCCTAGCAAACTAATATAGCATTCCTTTTTTAAAAAAGGCGTATCTCAGGGATATCTGGTACACTTCCTCTCTTCTATCCAGATGCCCAAACTCTGTATACGTCTCAGGCCCGACACAAGTATTAGTTACTCTGTGAAGCCAGGGTTAGAGCACTGGCCTGCCTCCCTGCGCACCACCCACAGAGGATGGCGGCACGGTTTCCATCAGGTCACATAGCTGGGCCCTCCGTTATG...
pathogenic
228,775
Variant at chromosome 15, position 28014869, gene OCA2 (OCA2 melanosomal transmembrane protein): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
TAACTAATTAAAGCACATTGAATTTATTAAATCTATAATTGCAAAATAATAGTAAAAAAGGGGAAGAGGGAAACTAAATAAATTCAGTGGACACCACTGGAAGTTACTAAGGGAAGAGCTCATTACTAAGAAAGTTGATCATTACAGAAATAGGATTTATCTTAGGCGGGCAGTGGGCCCTGGTGGGTATTAAAATCATTAAGAGAAAAAGTGGCAGGGAGCTGGGCACCTTTCTCCACCACCTCAACTCCCTGAGCATTCTCCGCACCCCTGACAGCAGGACATCCAGACATAGGGTCCTCCTCCTGGACACAGGCCAG...
TAACTAATTAAAGCACATTGAATTTATTAAATCTATAATTGCAAAATAATAGTAAAAAAGGGGAAGAGGGAAACTAAATAAATTCAGTGGACACCACTGGAAGTTACTAAGGGAAGAGCTCATTACTAAGAAAGTTGATCATTACAGAAATAGGATTTATCTTAGGCGGGCAGTGGGCCCTGGTGGGTATTAAAATCATTAAGAGAAAAAGTGGCAGGGAGCTGGGCACCTTTCTCCACCACCTCAACTCCCTGAGCATTCTCCGCACCCCTGACAGCAGGACATCCAGACATAGGGTCCTCCTCCTGGACACAGGCCAG...
pathogenic
228,784
Regarding the variant found on chromosome 15 at position 28016126 in gene OCA2 (OCA2 melanosomal transmembrane protein): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic
AAGCTCACTAGGACGCGCCTCTAACGGTCACATCATGCACTGACCTTCCAGGCTCCTGTCCGTGTTGTGGTTAAGTTTGATTTCATAGTTAAAGCAACAACGGACCTGCCCAGCCCAGGAAGGGTCTGCACATTGCTTCGTGCTATTGAAGGCATAGCCACACTTAGAACTTCCCAGAAACATAACATTGACTGGACTTAAGATCACATGTGGAAATGCCCATAAGCCAAGTTGGTAGACGGAACAGATAATCAAATAATCCCTCCGGGCACACAGCCCCAGGCCATCCGTGTCCCCTCACACACACAACCCCACGGTGC...
AAGCTCACTAGGACGCGCCTCTAACGGTCACATCATGCACTGACCTTCCAGGCTCCTGTCCGTGTTGTGGTTAAGTTTGATTTCATAGTTAAAGCAACAACGGACCTGCCCAGCCCAGGAAGGGTCTGCACATTGCTTCGTGCTATTGAAGGCATAGCCACACTTAGAACTTCCCAGAAACATAACATTGACTGGACTTAAGATCACATGTGGAAATGCCCATAAGCCAAGTTGGTAGACGGAACAGATAATCAAATAATCCCTCCGGGCACACAGCCCCAGGCCATCCGTGTCCCCTCACACACACAACCCCACGGTGC...
pathogenic
228,790
Variant at chromosome 15, position 28016172, gene OCA2 (OCA2 melanosomal transmembrane protein): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['OCA2-related_disorder', 'SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
TCCAGGCTCCTGTCCGTGTTGTGGTTAAGTTTGATTTCATAGTTAAAGCAACAACGGACCTGCCCAGCCCAGGAAGGGTCTGCACATTGCTTCGTGCTATTGAAGGCATAGCCACACTTAGAACTTCCCAGAAACATAACATTGACTGGACTTAAGATCACATGTGGAAATGCCCATAAGCCAAGTTGGTAGACGGAACAGATAATCAAATAATCCCTCCGGGCACACAGCCCCAGGCCATCCGTGTCCCCTCACACACACAACCCCACGGTGCAGGTGGGCGCAAATGAGCACACCCATCACACAGGTGCAGACTCTGA...
TCCAGGCTCCTGTCCGTGTTGTGGTTAAGTTTGATTTCATAGTTAAAGCAACAACGGACCTGCCCAGCCCAGGAAGGGTCTGCACATTGCTTCGTGCTATTGAAGGCATAGCCACACTTAGAACTTCCCAGAAACATAACATTGACTGGACTTAAGATCACATGTGGAAATGCCCATAAGCCAAGTTGGTAGACGGAACAGATAATCAAATAATCCCTCCGGGCACACAGCCCCAGGCCATCCGTGTCCCCTCACACACACAACCCCACGGTGCAGGTGGGCGCAAATGAGCACACCCATCACACAGGTGCAGACTCTGA...
pathogenic
228,792
Is the genetic variant on chromosome 15, position 28018444, gene OCA2 (OCA2 melanosomal transmembrane protein), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Tyrosinase-positive_oculocutaneous_albinism']
GTTTAAGAAAAAGGATTCAAAAGAAAAAATGCAGAATTAGTGTACAAAAGTACAAAAGGCATAGAAGTAAATAGTGATTTAATACGAGAAAAAGAAATCATGCCCAGACGCGCTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGTGGGAGGATCACTTGAGGCCAAGAGTTCAAGATCAGCCTGGGCAACAGAGCAAGACCCCTGTCTGCACAAAAAAGTTTTAAAAATTAGCCAGGCCTGGTGGCATGTGCTTGTGGTCCCAGCCACTTAGGGGCTGAGGCGGGAGGATCCTGTGAGCCCAGAAGTTCCA...
GTTTAAGAAAAAGGATTCAAAAGAAAAAATGCAGAATTAGTGTACAAAAGTACAAAAGGCATAGAAGTAAATAGTGATTTAATACGAGAAAAAGAAATCATGCCCAGACGCGCTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCAAGGTGGGAGGATCACTTGAGGCCAAGAGTTCAAGATCAGCCTGGGCAACAGAGCAAGACCCCTGTCTGCACAAAAAAGTTTTAAAAATTAGCCAGGCCTGGTGGCATGTGCTTGTGGTCCCAGCCACTTAGGGGCTGAGGCGGGAGGATCCTGTGAGCCCAGAAGTTCCA...
pathogenic
228,796
Assess the variant on chromosome 15, position 28022510, impacting OCA2 (OCA2 melanosomal transmembrane protein): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Inborn_genetic_diseases', 'OCA2-related_disorder', 'SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
TGGGTCAGCCTGGCAGCCGGTTGCTCTATCTCCCCTTCCCCCTGCGGGAAAGTCCTGCCCAGGAGGGTGGCATGTCCTGGGAACTTCATGAGGGGGGCCAGGAACACAGGGCAAGTCTTGGCTTTCTTCATCCTGGAGAAGTAATGCAGAGGTCGAGGCACAAGAATGAGAAACAAAGTCTGTCAACATCACACAGCTCTTCGGTTCTCTCACATGGAGATACTTTACAGCTCAGGCACGGTTTTAAAGTGATGAAGAAAATACAAACACGTGCACACGCACTCAGCTGACATCAGCACCGCCCTGACCCCAGTGGAAGT...
TGGGTCAGCCTGGCAGCCGGTTGCTCTATCTCCCCTTCCCCCTGCGGGAAAGTCCTGCCCAGGAGGGTGGCATGTCCTGGGAACTTCATGAGGGGGGCCAGGAACACAGGGCAAGTCTTGGCTTTCTTCATCCTGGAGAAGTAATGCAGAGGTCGAGGCACAAGAATGAGAAACAAAGTCTGTCAACATCACACAGCTCTTCGGTTCTCTCACATGGAGATACTTTACAGCTCAGGCACGGTTTTAAAGTGATGAAGAAAATACAAACACGTGCACACGCACTCAGCTGACATCAGCACCGCCCTGACCCCAGTGGAAGT...
pathogenic
228,800
The chromosome 15, position 28024851 genetic variant in gene OCA2 (OCA2 melanosomal transmembrane protein): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Oculocutaneous_albinism']
AATGCCTGGCCATAAAATTAAATCATCGAAGAAGGATAAATGTGGTTTTCTCACAATGGAGAATAAAGGCATATGACCCCTGTGATGGTTAGAGCATGTGTTTGTGGTAGCAGGTGTTTGTGAAATTTGCAAAGCACCTTATACACCATCAAAAAGTAAATTAAACTGATGATAACATGAGATTATAGAAGTTCAAATCATTCCTCAAATTCTATTTTGGATATCTCCACAAATCACCTAAACTCCATCTCACAGAAGAAGGCTGAAGACTGGACACAGAGCTCAGGTCAGCTCTTGGGGACCAGGGGAGACCTGGCCCA...
AATGCCTGGCCATAAAATTAAATCATCGAAGAAGGATAAATGTGGTTTTCTCACAATGGAGAATAAAGGCATATGACCCCTGTGATGGTTAGAGCATGTGTTTGTGGTAGCAGGTGTTTGTGAAATTTGCAAAGCACCTTATACACCATCAAAAAGTAAATTAAACTGATGATAACATGAGATTATAGAAGTTCAAATCATTCCTCAAATTCTATTTTGGATATCTCCACAAATCACCTAAACTCCATCTCACAGAAGAAGGCTGAAGACTGGACACAGAGCTCAGGTCAGCTCTTGGGGACCAGGGGAGACCTGGCCCA...
pathogenic
228,804
Variant chromosome 15, position 28027945, gene OCA2 (OCA2 melanosomal transmembrane protein): benign or pathogenic? Disease(s)?
pathogenic; ['Oculocutaneous_albinism', 'SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES']
GATCCTTTGAAAATGGTAAAATCTTGTTTTGCATTCTCTTAGATTTAATGAATTTGATGAATAATCAGTTCACGCTTCCCAATTACGATTCAACAGCTCCTACTTAAATAGGAATCAAAATGACATTTCTTTTTAAAGCATGAAGCATTAATTGAGCTATTCTAAATACAAATTTCTTTCTACGTAACTGACATCTGCAGCAGAGCTGACAACCCAAAATAAAAGGTTTTTTACAAGATTCTTCACTGATCACGCATGGTACTTTTTAGACATGTTATAAAGAATGGAGCTAACGTCTTTTAGTTCAGTGGCAAGCTCAA...
GATCCTTTGAAAATGGTAAAATCTTGTTTTGCATTCTCTTAGATTTAATGAATTTGATGAATAATCAGTTCACGCTTCCCAATTACGATTCAACAGCTCCTACTTAAATAGGAATCAAAATGACATTTCTTTTTAAAGCATGAAGCATTAATTGAGCTATTCTAAATACAAATTTCTTTCTACGTAACTGACATCTGCAGCAGAGCTGACAACCCAAAATAAAAGGTTTTTTACAAGATTCTTCACTGATCACGCATGGTACTTTTTAGACATGTTATAAAGAATGGAGCTAACGTCTTTTAGTTCAGTGGCAAGCTCAA...
pathogenic
228,808
Variant chromosome 15, position 28028010, gene OCA2 (OCA2 melanosomal transmembrane protein): benign or pathogenic? Disease(s)?
pathogenic; ['Tyrosinase-positive_oculocutaneous_albinism']
CAGTTCACGCTTCCCAATTACGATTCAACAGCTCCTACTTAAATAGGAATCAAAATGACATTTCTTTTTAAAGCATGAAGCATTAATTGAGCTATTCTAAATACAAATTTCTTTCTACGTAACTGACATCTGCAGCAGAGCTGACAACCCAAAATAAAAGGTTTTTTACAAGATTCTTCACTGATCACGCATGGTACTTTTTAGACATGTTATAAAGAATGGAGCTAACGTCTTTTAGTTCAGTGGCAAGCTCAAAGGCAAATATTCCATGAATCATAGAAGATAAAACAAGTACTGAATGCAAAAGTCTCAAATGTACT...
CAGTTCACGCTTCCCAATTACGATTCAACAGCTCCTACTTAAATAGGAATCAAAATGACATTTCTTTTTAAAGCATGAAGCATTAATTGAGCTATTCTAAATACAAATTTCTTTCTACGTAACTGACATCTGCAGCAGAGCTGACAACCCAAAATAAAAGGTTTTTTACAAGATTCTTCACTGATCACGCATGGTACTTTTTAGACATGTTATAAAGAATGGAGCTAACGTCTTTTAGTTCAGTGGCAAGCTCAAAGGCAAATATTCCATGAATCATAGAAGATAAAACAAGTACTGAATGCAAAAGTCTCAAATGTACT...
pathogenic
228,811
Considering the genetic mutation at chromosome 15, position 28081698, impacting OCA2 (OCA2 melanosomal transmembrane protein): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
GCATGGGAGGTGTGGCTCACTCATGAGGGCTCATGCCTGTGGACAAGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACC...
GCATGGGAGGTGTGGCTCACTCATGAGGGCTCATGCCTGTGGACAAGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACC...
pathogenic
228,818
Variant at chromosome position 28081711, chromosome 15, gene OCA2 (OCA2 melanosomal transmembrane protein): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
GGCTCACTCATGAGGGCTCATGCCTGTGGACAAGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCA...
GGCTCACTCATGAGGGCTCATGCCTGTGGACAAGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCA...
pathogenic
228,820
Variant on chromosome 15, at position 28081711, affecting OCA2 (OCA2 melanosomal transmembrane protein): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic
GGCTCACTCATGAGGGCTCATGCCTGTGGACAAGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCA...
GGCTCACTCATGAGGGCTCATGCCTGTGGACAAGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCA...
pathogenic
228,821
Clinical impact (benign or pathogenic) of the variant at chromosome 15, location 28081717, gene OCA2 (OCA2 melanosomal transmembrane protein): what disease(s) if pathogenic?
pathogenic; ['OCA2-related_disorder', 'SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
CTCATGAGGGCTCATGCCTGTGGACAAGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCAAGAAGT...
CTCATGAGGGCTCATGCCTGTGGACAAGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCAAGAAGT...
pathogenic
228,822
Gene OCA2 (OCA2 melanosomal transmembrane protein) variant at chromosome 15, position 28081743—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Inborn_genetic_diseases', 'SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
AGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCAAGAAGTGAGGTCAAAGAACTTGGAACATATGC...
AGGGTGGCACCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCAAGAAGTGAGGTCAAAGAACTTGGAACATATGC...
pathogenic
228,824
Is the chromosome 15, position 28081752 variant in OCA2 (OCA2 melanosomal transmembrane protein) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic
CCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCAAGAAGTGAGGTCAAAGAACTTGGAACATATGCAACATATGC...
CCTTCTGGCATCTCCACACTCAGCCTAGGTAGTTGCCAGTGCCATCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCAAGAAGTGAGGTCAAAGAACTTGGAACATATGCAACATATGC...
pathogenic
228,826
Is chromosome 15, position 28081796, gene OCA2 (OCA2 melanosomal transmembrane protein) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['SKIN/HAIR/EYE_PIGMENTATION_1,_BLUE/NONBLUE_EYES', 'Tyrosinase-positive_oculocutaneous_albinism']
TCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCAAGAAGTGAGGTCAAAGAACTTGGAACATATGCAACATATGCTCTTCTGGTTTTCCCAATTCTTGTCTCACTGGAAGCTGAACATT...
TCCCGACACCCCCTCCCCGTGCCCTGCGCAGGCTGTGGGGTCAGGGCACCCTCACCCTCCCTTCACTGGACCACCACACCTGCCAGCTCCTGCCCCCATGTGCCTGCACCTGTCAGCACCTCCCCACGCTCTCCTTCCTCCTCCACCTGGAATCCTGCCTGGCTGCCCAGGGCCTCCTGCCTGTGGAGCTCATGACAGGCCCCAGTCTGCCCCTGGTACACCATACATCGAAGCAAGAAGTGAGGTCAAAGAACTTGGAACATATGCAACATATGCTCTTCTGGTTTTCCCAATTCTTGTCTCACTGGAAGCTGAACATT...
pathogenic
228,827
Mutation at chromosome 15, position 30922219, within FAN1: benign or pathogenic? If pathogenic, indicate the disease(s).
benign
GTTTCATACAATTTTCGCATACCAAAGTGTATTATTCTCTTTATTTATTAACAATTTAAAAACATAAAAACCATTCTTAGTTTGCAGGACATAGAAAATCAGGTGGCAGACCCTGGGTTTGGCTGTGGGCCGGAGTTTGCTGACCTTGGTTTAGAATGATGAGTTCTCATCTTACTCCACTGTCTGAGTGACCTAGGACGTGGTAGCTGGCTGTGAGAATGTAGGTTTGTGGTGTAGAAAATTGTACACAACTGAAAGTATTTAGAATATACCTTTTTAAAAGATAGGAATTCAGTCTGCTTTGTCACTTGTTATTATTG...
GTTTCATACAATTTTCGCATACCAAAGTGTATTATTCTCTTTATTTATTAACAATTTAAAAACATAAAAACCATTCTTAGTTTGCAGGACATAGAAAATCAGGTGGCAGACCCTGGGTTTGGCTGTGGGCCGGAGTTTGCTGACCTTGGTTTAGAATGATGAGTTCTCATCTTACTCCACTGTCTGAGTGACCTAGGACGTGGTAGCTGGCTGTGAGAATGTAGGTTTGTGGTGTAGAAAATTGTACACAACTGAAAGTATTTAGAATATACCTTTTTAAAAGATAGGAATTCAGTCTGCTTTGTCACTTGTTATTATTG...
benign
228,948
Does the genetic variant at chromosome 15, position 31026196, impacting gene TRPM1, appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Congenital_stationary_night_blindness_1C']
TGCTGGCGAAGACACGACCGAGAGAAGAGCAGGAAAATCATCAAATGGGAAATGGTGATGCAGAAAATAAAACTAATTTTATATAGAAAGAATATTAAAGAAATGGCAGAAATGCTTGAGTACTTCAAGTGTGATTTTTAAAGTAGTCACAGGTGCCCAAATAGCTACTTTTATTTCCATCCTCCCACCTTATCCCTTGCTTCTCAGCTGGCTTGGCTAAGAGGGAAGGAAAACTCCCTTCTCCTCAAGCCTTCTCCTCTTTCTGTCTTGGGCATTCACCTGTGAGTCAGCCTGACAAGGCCAAGGGAAATGGAGGGGCA...
TGCTGGCGAAGACACGACCGAGAGAAGAGCAGGAAAATCATCAAATGGGAAATGGTGATGCAGAAAATAAAACTAATTTTATATAGAAAGAATATTAAAGAAATGGCAGAAATGCTTGAGTACTTCAAGTGTGATTTTTAAAGTAGTCACAGGTGCCCAAATAGCTACTTTTATTTCCATCCTCCCACCTTATCCCTTGCTTCTCAGCTGGCTTGGCTAAGAGGGAAGGAAAACTCCCTTCTCCTCAAGCCTTCTCCTCTTTCTGTCTTGGGCATTCACCTGTGAGTCAGCCTGACAAGGCCAAGGGAAATGGAGGGGCA...
pathogenic
228,997
Determine whether the variant at chromosome 15, position 31031004, in gene TRPM1 (transient receptor potential cation channel subfamily M member 1) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Congenital_stationary_night_blindness_1C']
TTCTAATTATTTAACATCAGCTTATGTTGTCTTCTGGTTGTTTTCTTGGTTTCACTGATACATTAAATTTGAAAATATTTTTGTTATGTTGTATGGGTTAGGGATTTCCTCTACTTCCCAAATTGTTTAATCAACTGTTTTGGTGCCATGTTTGAAAAATAATCTTTTCTCCCTCTGCTCATTTGAAATGCAACTTTTTATCATAGGGGGTCTATTTCTCCCCTAAAAAAATAGGGTGATCCCAACAGTGAATTTGTGGTTCTCTTTACTTTTTACTGACAGCTTAAAAAGTACTGGCACCAAAAAACAAGAGAAGTATT...
TTCTAATTATTTAACATCAGCTTATGTTGTCTTCTGGTTGTTTTCTTGGTTTCACTGATACATTAAATTTGAAAATATTTTTGTTATGTTGTATGGGTTAGGGATTTCCTCTACTTCCCAAATTGTTTAATCAACTGTTTTGGTGCCATGTTTGAAAAATAATCTTTTCTCCCTCTGCTCATTTGAAATGCAACTTTTTATCATAGGGGGTCTATTTCTCCCCTAAAAAAATAGGGTGATCCCAACAGTGAATTTGTGGTTCTCTTTACTTTTTACTGACAGCTTAAAAAGTACTGGCACCAAAAAACAAGAGAAGTATT...
pathogenic
229,005
Benign or pathogenic: chromosome 15, position 31038139, gene TRPM1 (transient receptor potential cation channel subfamily M member 1) variant? Disease(s) if pathogenic?
pathogenic; ['Congenital_stationary_night_blindness_1C']
GTTAGATGAGAGGACATGTGGATGAGTTGCCCACCCAGATATGCGAGCTGACCCTAGAGTCCCCTCAGTTACTGGTGGCATGTCCAGGATTTGCTGTGGCCACAGCAGGGCCCCTATCTCTGTGGCAGGGAAAGAGGCAGAGCTGGAGGTGGCAGTGGGTGAGGCAAAAGCGGGGAGTTAAGGGGTTGGGGGAGGACGTCTGAAGTAGATCACCTGTCCCCAGTGATTCACCATGATGCCAAGGAAACTTAAGCTTCTGGGTCCCTCACTGGCACAGGCCCCTGTGGAAGGCTTGGGGGAGGGGTGCTAAAAACTGAGTA...
GTTAGATGAGAGGACATGTGGATGAGTTGCCCACCCAGATATGCGAGCTGACCCTAGAGTCCCCTCAGTTACTGGTGGCATGTCCAGGATTTGCTGTGGCCACAGCAGGGCCCCTATCTCTGTGGCAGGGAAAGAGGCAGAGCTGGAGGTGGCAGTGGGTGAGGCAAAAGCGGGGAGTTAAGGGGTTGGGGGAGGACGTCTGAAGTAGATCACCTGTCCCCAGTGATTCACCATGATGCCAAGGAAACTTAAGCTTCTGGGTCCCTCACTGGCACAGGCCCCTGTGGAAGGCTTGGGGGAGGGGTGCTAAAAACTGAGTA...
pathogenic
229,018
Gene mutation in FMN1 (formin 1) at chromosome 15, position 32798901—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
CTTATTAGCCATCATCAACTTTCAGAGATGTTGTTTTAGGGTAGAAACCTTGGTGATCCATCCTCACAGAGCATGGCTGGAATGAAGGGTCCCCTGAAACTGCGAAATGAGAAGAACCAAAAAGGGTCTTGTGAGGTCATGACCCTGTAAAGGGGTTGGTTTACAGAGTGTGAAGCAGGCAATTCAACAGCTGCACCCAGGAAGCAATGCCACAAACGCCCGTGGCTGGGAATCAGAGATACTGTCATTTTGAAGGACTTCTGGATACCACCTCTATGACAGACTCACAATTTCTTTGATCTAACTTCTATGATACAGAA...
CTTATTAGCCATCATCAACTTTCAGAGATGTTGTTTTAGGGTAGAAACCTTGGTGATCCATCCTCACAGAGCATGGCTGGAATGAAGGGTCCCCTGAAACTGCGAAATGAGAAGAACCAAAAAGGGTCTTGTGAGGTCATGACCCTGTAAAGGGGTTGGTTTACAGAGTGTGAAGCAGGCAATTCAACAGCTGCACCCAGGAAGCAATGCCACAAACGCCCGTGGCTGGGAATCAGAGATACTGTCATTTTGAAGGACTTCTGGATACCACCTCTATGACAGACTCACAATTTCTTTGATCTAACTTCTATGATACAGAA...
benign
229,142
Variant chromosome 15, position 33821253, gene RYR3 (ryanodine receptor 3): benign or pathogenic? Disease(s)?
benign
ACAGCCTAAAACTATAAACTTCATCTCTGAATTCCATGTTAAGCCCCTGCTGGTTCACATTTTCAGAGTGGTTTCTAAGAATCAGAGTGGGGGAAGGGATTTTCTAATTAATTCACTAGTACTTATAATTTGAGATTTATATGACTCTTAGTCTTTATTGTGGGGTCCAAAGAGTAGCCTGCTAAGGCTGGGCATGGTGGCTCATGCCTGTAATTCCAGCATTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGTGAAACCCCATCTCTACTAAAAATATAAAAAAG...
ACAGCCTAAAACTATAAACTTCATCTCTGAATTCCATGTTAAGCCCCTGCTGGTTCACATTTTCAGAGTGGTTTCTAAGAATCAGAGTGGGGGAAGGGATTTTCTAATTAATTCACTAGTACTTATAATTTGAGATTTATATGACTCTTAGTCTTTATTGTGGGGTCCAAAGAGTAGCCTGCTAAGGCTGGGCATGGTGGCTCATGCCTGTAATTCCAGCATTTTGGGAGGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAATATGGTGAAACCCCATCTCTACTAAAAATATAAAAAAG...
benign
229,322
Assess the variant on chromosome 15, position 33844878, impacting RYR3 (ryanodine receptor 3): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
benign
GATCACGAAAATGCAGTCACACAGCACTTCAAGGCAAGGCTCGAGTCCTCTGCTGGTGGCGTGTTTAGGCCTTTGGCTCCCTGAGCAATAAAGCCAGAGCAGGATTCTTTATACCAATTCTAAGCAATTTTTTTTTAAATCAACATTTTGGTTCCATGTTCATGACACGACACAGTCATGCCATGGCTGTGTTAAGAATGCCAGGGTTGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTC...
GATCACGAAAATGCAGTCACACAGCACTTCAAGGCAAGGCTCGAGTCCTCTGCTGGTGGCGTGTTTAGGCCTTTGGCTCCCTGAGCAATAAAGCCAGAGCAGGATTCTTTATACCAATTCTAAGCAATTTTTTTTTAAATCAACATTTTGGTTCCATGTTCATGACACGACACAGTCATGCCATGGCTGTGTTAAGAATGCCAGGGTTGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCGAGATGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCGTC...
benign
229,339
Does the variant on chromosome 15 at location 34236021 affecting gene SLC12A6 (solute carrier family 12 member 6) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
CTTCAAAACTTGTCAAGGAGACAGGCAAAAGAAGAGCACAAACTTAAAACCTGGCATCATCATAATCTGAGGTTATCTGATCATAGAGCTACAAAATTAGCTGCTTAATTATTATATATTCAGAAAAGTCTGAACTTTGGATTGAATTTAACCCTGTGAAGTAACCAGAGATCCAGTCCTTTTGCATACATAATACCAGACTCCCATTTGTGTATTTAAAAAATGGGAAAACCTAGAAGTGTTACTCTAAATAAGATAAAAATGATGAAAGAAGAAGAAAAGCCACAATAGGGCAGCTAACAAGATTCCTAGAGAGAACC...
CTTCAAAACTTGTCAAGGAGACAGGCAAAAGAAGAGCACAAACTTAAAACCTGGCATCATCATAATCTGAGGTTATCTGATCATAGAGCTACAAAATTAGCTGCTTAATTATTATATATTCAGAAAAGTCTGAACTTTGGATTGAATTTAACCCTGTGAAGTAACCAGAGATCCAGTCCTTTTGCATACATAATACCAGACTCCCATTTGTGTATTTAAAAAATGGGAAAACCTAGAAGTGTTACTCTAAATAAGATAAAAATGATGAAAGAAGAAGAAAAGCCACAATAGGGCAGCTAACAAGATTCCTAGAGAGAACC...
pathogenic
229,365
A mutation at chromosome position 34236206 on chromosome 15 in gene SLC12A6 (solute carrier family 12 member 6): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
benign
ATACATAATACCAGACTCCCATTTGTGTATTTAAAAAATGGGAAAACCTAGAAGTGTTACTCTAAATAAGATAAAAATGATGAAAGAAGAAGAAAAGCCACAATAGGGCAGCTAACAAGATTCCTAGAGAGAACCCAAGTAATTTCTAAGTGAAGCTGCTCAAGTCAGATTTTTCTGCCAGTTCGGTTTGTCTTTTTCTTTTTAAACCTTTTTCTTTTCTTTCTTTTTTTTTTGAGACAGAATTTCCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTTGGCTCACTGCAACCTCCACCTCCTGGTTCAAGTGAT...
ATACATAATACCAGACTCCCATTTGTGTATTTAAAAAATGGGAAAACCTAGAAGTGTTACTCTAAATAAGATAAAAATGATGAAAGAAGAAGAAAAGCCACAATAGGGCAGCTAACAAGATTCCTAGAGAGAACCCAAGTAATTTCTAAGTGAAGCTGCTCAAGTCAGATTTTTCTGCCAGTTCGGTTTGTCTTTTTCTTTTTAAACCTTTTTCTTTTCTTTCTTTTTTTTTTGAGACAGAATTTCCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCTTGGCTCACTGCAACCTCCACCTCCTGGTTCAAGTGAT...
benign
229,369
Clinical impact (benign or pathogenic) of the variant at chromosome 15, location 34236786, gene SLC12A6 (solute carrier family 12 member 6): what disease(s) if pathogenic?
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
TCCCGTATCCCAGGAGTCCTGGGATGAAGGTATGAGGAAGAATCCCTATCTCTTTTTTCCCCTCAGTTAAAGGAGGTTCTATCTCAGCTTCTCCCCTAACTCTATCCAAAAGAAAGGCTTTGCAAAGCGGGTAGAACCTAAAAAGGCGAAAGGATGTGGGTATGCTGTCTGTAGGATTGTCAGGAAGGGTTTTATACACTGAATATTAGATGTCATGTTGCAAATACACCACCTAAAACTAGAACTGAATTATATTTGCCCCAACTCCCCTAAAAGAGTTTAATCTTATAACTTTGTAAAAATCCTTGCCTAGGACTTTT...
TCCCGTATCCCAGGAGTCCTGGGATGAAGGTATGAGGAAGAATCCCTATCTCTTTTTTCCCCTCAGTTAAAGGAGGTTCTATCTCAGCTTCTCCCCTAACTCTATCCAAAAGAAAGGCTTTGCAAAGCGGGTAGAACCTAAAAAGGCGAAAGGATGTGGGTATGCTGTCTGTAGGATTGTCAGGAAGGGTTTTATACACTGAATATTAGATGTCATGTTGCAAATACACCACCTAAAACTAGAACTGAATTATATTTGCCCCAACTCCCCTAAAAGAGTTTAATCTTATAACTTTGTAAAAATCCTTGCCTAGGACTTTT...
pathogenic
229,376
Gene SLC12A6 (solute carrier family 12 member 6) variant at chromosome position 34238297 on chromosome 15: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
CTTCATCTTTGGTTATTTTGAAGCAGTAATGGGTTATAGTGGAATAACTGACAGAGTGAGAAGGAATTTGTCATCCTTGAAAACAATATAGTATCATCCCTTTTTTTTTTGGTTTGAGACAGAGTCTTCCTCTGTCACGCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTTAAGCACTTCTCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTCGTACTTTAGTACAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACT...
CTTCATCTTTGGTTATTTTGAAGCAGTAATGGGTTATAGTGGAATAACTGACAGAGTGAGAAGGAATTTGTCATCCTTGAAAACAATATAGTATCATCCCTTTTTTTTTTGGTTTGAGACAGAGTCTTCCTCTGTCACGCAGGCTGGAGTGCAGTGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCTGGGTTTAAGCACTTCTCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTCGTACTTTAGTACAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAACT...
pathogenic
229,386
Regarding the variant found on chromosome 15 at position 34239087 in gene SLC12A6: is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
GTGTTGCCTTGAAACACAAAATACAAACTCCAGTCTCTCTTTTTTATACTGTTAGGTTTTTTTTAAAAGCCATGTGTGATTTTAAGCTGAATATATGAATAAAAATTTCATAAAACTATATTAAGCAGATGAGAATCTGGCAGAAATATAAGGGCTGTGTAATAAACAAGAAAGCAAAACCAAAAAATAACATCAAACATGCATCACATATACATTCTACTTAGGGCAACAAATTAGGGTTTTTTTTTGTTTTTTTTTTGGCACTAGGGGATTAATCCACATTTAGATCTGAAAAATTTCCCAAACCAGAAAAGATTCAA...
GTGTTGCCTTGAAACACAAAATACAAACTCCAGTCTCTCTTTTTTATACTGTTAGGTTTTTTTTAAAAGCCATGTGTGATTTTAAGCTGAATATATGAATAAAAATTTCATAAAACTATATTAAGCAGATGAGAATCTGGCAGAAATATAAGGGCTGTGTAATAAACAAGAAAGCAAAACCAAAAAATAACATCAAACATGCATCACATATACATTCTACTTAGGGCAACAAATTAGGGTTTTTTTTTGTTTTTTTTTTGGCACTAGGGGATTAATCCACATTTAGATCTGAAAAATTTCCCAAACCAGAAAAGATTCAA...
pathogenic
229,390
The genetic variant at chromosome 15, position 34240659, affecting gene SLC12A6 (solute carrier family 12 member 6): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy', 'Charcot-Marie-Tooth_disease', 'Charcot-Marie-Tooth_disease,_axonal,_IIa_2II', 'SLC12A6-related_disorder']
ATTCCCATTACTACATTTCTAAGGGGGGATATGTGAATTTGAGAGATTATGATGCTGAAGAACAATTCTTGCAATTCCTGTGAGAACATCAATATGGAAAATCACAAATGAAAACACGGCAATTTTGGAGATAATTCCTAGCACAAGACTTGACAGAAATAATTCATGAACATAATGTGAAGCTGAAGGGGGTAGGTAGAATCTGGGTATTACTACCAATAGTTTTTCAGGTTGCCTTATAAGACTATGCTTCAGCAATGGCATAGTCTCTACTTTAGGAGGCTGGGGGTGACAGAGATTTAACTATATACCCTCGACTT...
ATTCCCATTACTACATTTCTAAGGGGGGATATGTGAATTTGAGAGATTATGATGCTGAAGAACAATTCTTGCAATTCCTGTGAGAACATCAATATGGAAAATCACAAATGAAAACACGGCAATTTTGGAGATAATTCCTAGCACAAGACTTGACAGAAATAATTCATGAACATAATGTGAAGCTGAAGGGGGTAGGTAGAATCTGGGTATTACTACCAATAGTTTTTCAGGTTGCCTTATAAGACTATGCTTCAGCAATGGCATAGTCTCTACTTTAGGAGGCTGGGGGTGACAGAGATTTAACTATATACCCTCGACTT...
pathogenic
229,393
The mutation impacting SLC12A6 (solute carrier family 12 member 6) on chromosome 15 at position 34241319: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
TATATCATCTACAGAAAAGTCCAAAAAGTTAAAATTATCCCAAAGGAATTTCATGATCTTTTGTCTTTTTGCTTACTACGTATTTTTGCCTCTGTAGCTGGTTGTCTACATGTAGTTTCTCTGCTTTTTCCTCTGTTCTGCTTTTGTTCCTTTGCACCATACCAAAAAACTGGGAACAGGGATCTCTACAAAGTGAATATTCAACATTCTTTCTCAGTTGACCAGGGTGATTCACTATTGTGAACACGATCTCCTTCCTGCCTCAGCCCCAGTCATGCCCTGACTCATCTTACCAGAAACTCAGTATGATGATTCAGTTT...
TATATCATCTACAGAAAAGTCCAAAAAGTTAAAATTATCCCAAAGGAATTTCATGATCTTTTGTCTTTTTGCTTACTACGTATTTTTGCCTCTGTAGCTGGTTGTCTACATGTAGTTTCTCTGCTTTTTCCTCTGTTCTGCTTTTGTTCCTTTGCACCATACCAAAAAACTGGGAACAGGGATCTCTACAAAGTGAATATTCAACATTCTTTCTCAGTTGACCAGGGTGATTCACTATTGTGAACACGATCTCCTTCCTGCCTCAGCCCCAGTCATGCCCTGACTCATCTTACCAGAAACTCAGTATGATGATTCAGTTT...
pathogenic
229,398
Determine if the mutation at chromosome 15, position 34244065 in gene SLC12A6 (solute carrier family 12 member 6) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
TTAAGATATTTTCACTGAGCTGGCTCTAACCAAACTAGCTAGTCTTGCTACTTTTAGCAGTGATCAAGATTAAATCCACACTCACCCTTGGTATTCAATGTACTTGTAGATCATACCAGCTATTACCATGGCTACAATGGCATAATACCAGGAAGAAATGAACATCAGAGCCAGACAGATACTCATTCCCATGAAAGAAAGGGCCCTAGAAAATTAAAAACAAAAAAGTATCTTTTAAAGTAGCTGAAAAAGAAGCCTATGTTAAAGGTGCTTCTCAAACTATCTGTGGTGAGGTATTATTTTTTAAAAACTTTGAAACT...
TTAAGATATTTTCACTGAGCTGGCTCTAACCAAACTAGCTAGTCTTGCTACTTTTAGCAGTGATCAAGATTAAATCCACACTCACCCTTGGTATTCAATGTACTTGTAGATCATACCAGCTATTACCATGGCTACAATGGCATAATACCAGGAAGAAATGAACATCAGAGCCAGACAGATACTCATTCCCATGAAAGAAAGGGCCCTAGAAAATTAAAAACAAAAAAGTATCTTTTAAAGTAGCTGAAAAAGAAGCCTATGTTAAAGGTGCTTCTCAAACTATCTGTGGTGAGGTATTATTTTTTAAAAACTTTGAAACT...
pathogenic
229,408
The chromosome 15, position 34245696 genetic variant in gene SLC12A6 (solute carrier family 12 member 6): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
TAGAACCTCTGACTCTGTAACCCTAAGAGACAAACAGGAAAATAAACATGCAAGAGAAGGTTGTTTTAACCTGAAAATTATAGAAGGCTGGATATCTCTATTTAGTGCTTTTGCTCTATTCGTATTGGGTGTTATAAGTTATTATAAAGTGATATAGGAAAATAGGATAGGAGGATGAGGATTCAGATAAGAATTGAAAGTTGAAACAGTATGAAATGGCTGACCAAGAAAAAAATTTTATCGAGAACCCAGACTCTCCTAGTTTTCTAGTTCAAAGATGGGTTCTCTCCAAACGTGAGTAAAAAGAATAAAAGAAGCAG...
TAGAACCTCTGACTCTGTAACCCTAAGAGACAAACAGGAAAATAAACATGCAAGAGAAGGTTGTTTTAACCTGAAAATTATAGAAGGCTGGATATCTCTATTTAGTGCTTTTGCTCTATTCGTATTGGGTGTTATAAGTTATTATAAAGTGATATAGGAAAATAGGATAGGAGGATGAGGATTCAGATAAGAATTGAAAGTTGAAACAGTATGAAATGGCTGACCAAGAAAAAAATTTTATCGAGAACCCAGACTCTCCTAGTTTTCTAGTTCAAAGATGGGTTCTCTCCAAACGTGAGTAAAAAGAATAAAAGAAGCAG...
pathogenic
229,416
Variant in gene SLC12A6 (solute carrier family 12 member 6), located at chromosome 15 position 34250365: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
GTGAATTAGTCTTGATGCACATGTGCAAGCATTTCTGTTAGATATACCTAGAAGTGGAAATGCTGAGTCATAGGTAAGCACATGTTCAACTTTAGGAGATAATAACCAATAATTTTCCAAAATGATACTCTAATTTACACTCTCAATAATAATTTTTATATCATGGTGTAACTTACCAAAGCTCCATGAATTTCCTACTACAATGGTATAGTAATATACTATACTATATACATACATATATACACCCCCACCCACACACACACACACACACACACATATACTGTGTTATATACATATATATATTGTGCTTTTTATTTTTG...
GTGAATTAGTCTTGATGCACATGTGCAAGCATTTCTGTTAGATATACCTAGAAGTGGAAATGCTGAGTCATAGGTAAGCACATGTTCAACTTTAGGAGATAATAACCAATAATTTTCCAAAATGATACTCTAATTTACACTCTCAATAATAATTTTTATATCATGGTGTAACTTACCAAAGCTCCATGAATTTCCTACTACAATGGTATAGTAATATACTATACTATATACATACATATATACACCCCCACCCACACACACACACACACACACACATATACTGTGTTATATACATATATATATTGTGCTTTTTATTTTTG...
benign
229,425
Evaluate the clinical significance of the mutation at chromosome 15, position 34250741 in gene SLC12A6 (solute carrier family 12 member 6): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
benign
TAGGGGAGAGTAATATGAAAACAAGTAGCTGCAATATAGCATCATAAATGCTATAATATAGTATATTCAAATGGAGTTGCTGAACACAAGGTGGAGTGTTTACCTCTGTTTGGGTGAGTATGGGAAAGCTTTACAGGAGAGAAGACCCTTAGCCTAGTCTCTAAGAGGATGAATATGAGTTGGCCAGGTGGGAGTAACCTATTCTAAGCAAAGGAAATAACACAGACAAATGTGTTTATACGTGGAGACATAATAAGACATATTAAACTCTAAGTTAGGGAGCTTATGAGGGAATGGCAGGAGATAACAGTAAAAAGAGG...
TAGGGGAGAGTAATATGAAAACAAGTAGCTGCAATATAGCATCATAAATGCTATAATATAGTATATTCAAATGGAGTTGCTGAACACAAGGTGGAGTGTTTACCTCTGTTTGGGTGAGTATGGGAAAGCTTTACAGGAGAGAAGACCCTTAGCCTAGTCTCTAAGAGGATGAATATGAGTTGGCCAGGTGGGAGTAACCTATTCTAAGCAAAGGAAATAACACAGACAAATGTGTTTATACGTGGAGACATAATAAGACATATTAAACTCTAAGTTAGGGAGCTTATGAGGGAATGGCAGGAGATAACAGTAAAAAGAGG...
benign
229,430
Regarding the variant found on chromosome 15 at position 34250746 in gene SLC12A6 (solute carrier family 12 member 6): is it benign or pathogenic? If pathogenic, identify the disease(s).
benign
GAGAGTAATATGAAAACAAGTAGCTGCAATATAGCATCATAAATGCTATAATATAGTATATTCAAATGGAGTTGCTGAACACAAGGTGGAGTGTTTACCTCTGTTTGGGTGAGTATGGGAAAGCTTTACAGGAGAGAAGACCCTTAGCCTAGTCTCTAAGAGGATGAATATGAGTTGGCCAGGTGGGAGTAACCTATTCTAAGCAAAGGAAATAACACAGACAAATGTGTTTATACGTGGAGACATAATAAGACATATTAAACTCTAAGTTAGGGAGCTTATGAGGGAATGGCAGGAGATAACAGTAAAAAGAGGTAGAG...
GAGAGTAATATGAAAACAAGTAGCTGCAATATAGCATCATAAATGCTATAATATAGTATATTCAAATGGAGTTGCTGAACACAAGGTGGAGTGTTTACCTCTGTTTGGGTGAGTATGGGAAAGCTTTACAGGAGAGAAGACCCTTAGCCTAGTCTCTAAGAGGATGAATATGAGTTGGCCAGGTGGGAGTAACCTATTCTAAGCAAAGGAAATAACACAGACAAATGTGTTTATACGTGGAGACATAATAAGACATATTAAACTCTAAGTTAGGGAGCTTATGAGGGAATGGCAGGAGATAACAGTAAAAAGAGGTAGAG...
benign
229,431
Mutation at chromosome 15, position 34255361, within SLC12A6 (solute carrier family 12 member 6): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
TGTACTAATCAAAAAAGAGGAGAAGCCCCAAAGGTGAACCTGAGACAAAATGGAATTTCCCAAATTGAGATATAACCAGAATGTCACCTTTAGAAATTTTATGCCCCTAAAAAGGACCTTCAGCTGTATTACAGTCCCTAGATAAGCAGATTAAAAGTTTAAGATGGAATCTACTTCTGCCATCATGCAGCATAGCATAGAAGAAATACTGAATGGGGAGTCAGGAAATCACAGTTCATCTTCTTGCTCTGCCATTAATTAACTTTGAGGTAAGTCATTAAACCTACTGGAACTGTCTTTTTGTCTTGAAAAATCTTTTT...
TGTACTAATCAAAAAAGAGGAGAAGCCCCAAAGGTGAACCTGAGACAAAATGGAATTTCCCAAATTGAGATATAACCAGAATGTCACCTTTAGAAATTTTATGCCCCTAAAAAGGACCTTCAGCTGTATTACAGTCCCTAGATAAGCAGATTAAAAGTTTAAGATGGAATCTACTTCTGCCATCATGCAGCATAGCATAGAAGAAATACTGAATGGGGAGTCAGGAAATCACAGTTCATCTTCTTGCTCTGCCATTAATTAACTTTGAGGTAAGTCATTAAACCTACTGGAACTGTCTTTTTGTCTTGAAAAATCTTTTT...
pathogenic
229,457
Variant at chromosome 15, position 34255385, gene SLC12A6 (solute carrier family 12 member 6): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Abnormal_facial_shape', 'Clinodactyly_of_the_5th_finger', 'Corpus_callosum,_agenesis_of', 'Hypertelorism', 'Low-set_ears']
GCCCCAAAGGTGAACCTGAGACAAAATGGAATTTCCCAAATTGAGATATAACCAGAATGTCACCTTTAGAAATTTTATGCCCCTAAAAAGGACCTTCAGCTGTATTACAGTCCCTAGATAAGCAGATTAAAAGTTTAAGATGGAATCTACTTCTGCCATCATGCAGCATAGCATAGAAGAAATACTGAATGGGGAGTCAGGAAATCACAGTTCATCTTCTTGCTCTGCCATTAATTAACTTTGAGGTAAGTCATTAAACCTACTGGAACTGTCTTTTTGTCTTGAAAAATCTTTTTTTCTGTAATCTGGTTAAATCAACA...
GCCCCAAAGGTGAACCTGAGACAAAATGGAATTTCCCAAATTGAGATATAACCAGAATGTCACCTTTAGAAATTTTATGCCCCTAAAAAGGACCTTCAGCTGTATTACAGTCCCTAGATAAGCAGATTAAAAGTTTAAGATGGAATCTACTTCTGCCATCATGCAGCATAGCATAGAAGAAATACTGAATGGGGAGTCAGGAAATCACAGTTCATCTTCTTGCTCTGCCATTAATTAACTTTGAGGTAAGTCATTAAACCTACTGGAACTGTCTTTTTGTCTTGAAAAATCTTTTTTTCTGTAATCTGGTTAAATCAACA...
pathogenic
229,458
Gene SLC12A6 (solute carrier family 12 member 6) variant at chromosome 15, position 34257759—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
CTCTAATGGTAGCACTTTGGGAGGATGAGGCGAGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAAACTGGGTAACATAGTAAAATGTCACCTCTGTAAAAAAAAAAAAATAGCCAGGCATAGTGGTGTACACCTCTAGTTCCAGCTACTCAGGAGGCTGAAGTGGGAAAGCAGCTTGAGCCTAGGAGTTGGAGGCTGTGTGAGCTATGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTATAAAAAAATATATATTCCAACTAATAAAAGCTAAGAATGTGACTGAAATTAATGCATTCTAGT...
CTCTAATGGTAGCACTTTGGGAGGATGAGGCGAGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAAACTGGGTAACATAGTAAAATGTCACCTCTGTAAAAAAAAAAAAATAGCCAGGCATAGTGGTGTACACCTCTAGTTCCAGCTACTCAGGAGGCTGAAGTGGGAAAGCAGCTTGAGCCTAGGAGTTGGAGGCTGTGTGAGCTATGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTATAAAAAAATATATATTCCAACTAATAAAAGCTAAGAATGTGACTGAAATTAATGCATTCTAGT...
pathogenic
229,466
Determine if the mutation at chromosome 15, position 34257781 in gene SLC12A6 (solute carrier family 12 member 6) is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Agenesis_of_the_corpus_callosum_with_peripheral_neuropathy']
GGATGAGGCGAGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAAACTGGGTAACATAGTAAAATGTCACCTCTGTAAAAAAAAAAAAATAGCCAGGCATAGTGGTGTACACCTCTAGTTCCAGCTACTCAGGAGGCTGAAGTGGGAAAGCAGCTTGAGCCTAGGAGTTGGAGGCTGTGTGAGCTATGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTATAAAAAAATATATATTCCAACTAATAAAAGCTAAGAATGTGACTGAAATTAATGCATTCTAGTTTAAAAAATAAAGAGATTTTAA...
GGATGAGGCGAGAGGATTGCTTGAGGCCAGGAGTTTGAGACCAAACTGGGTAACATAGTAAAATGTCACCTCTGTAAAAAAAAAAAAATAGCCAGGCATAGTGGTGTACACCTCTAGTTCCAGCTACTCAGGAGGCTGAAGTGGGAAAGCAGCTTGAGCCTAGGAGTTGGAGGCTGTGTGAGCTATGATCGTGTCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTATAAAAAAATATATATTCCAACTAATAAAAGCTAAGAATGTGACTGAAATTAATGCATTCTAGTTTAAAAAATAAAGAGATTTTAA...
pathogenic
229,467
The genetic variant at chromosome 15, position 34275365, affecting gene SLC12A6 (solute carrier family 12 member 6): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['SLC12A6-related_disorder']
CTCCAGCCTGGGTGACAGATCAAGACTCCATCTCAAAAAAACCAAAAACCAAAAAAACAAAAAACCTCTAACATCACACGGTCAGGACCTTGGTGATCAGATTTGTATATTTATGTCAAACCATTTACTTAACAAATATATACTGAGTGCCTAGGATGTCAGGTACTGTTTCAGCATATAAACTCACTAAAGGAATGAGGGCTATGGTCTCATAAACTCTTCTCATTAACCCAAGGACTATCCTAAGTCTTTAATATAGAAAGAACGAAAAAGGAGTATCCCAGTTTCTTCAACTAATCCTCTGAAGTTTTTACTTTCCC...
CTCCAGCCTGGGTGACAGATCAAGACTCCATCTCAAAAAAACCAAAAACCAAAAAAACAAAAAACCTCTAACATCACACGGTCAGGACCTTGGTGATCAGATTTGTATATTTATGTCAAACCATTTACTTAACAAATATATACTGAGTGCCTAGGATGTCAGGTACTGTTTCAGCATATAAACTCACTAAAGGAATGAGGGCTATGGTCTCATAAACTCTTCTCATTAACCCAAGGACTATCCTAAGTCTTTAATATAGAAAGAACGAAAAAGGAGTATCCCAGTTTCTTCAACTAATCCTCTGAAGTTTTTACTTTCCC...
pathogenic
229,491
Does the chromosome 15 mutation at position 34791307 within gene ACTC1 classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,571
Is chromosome 15, position 34791307, gene ACTC1 variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,572
A genetic variant on chromosome 15, position 34791307, affects the gene ACTC1. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,573
Considering the genetic mutation at chromosome 15, position 34791307, impacting ACTC1: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,574
A mutation at chromosome position 34791307 on chromosome 15 in gene ACTC1: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,575
Is the chromosome 15, position 34791307 variant in ACTC1 clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,576
Located at chromosome 15 position 34791307, the variant affecting gene ACTC1—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,577
Variant in ACTC1, chromosome 15, position 34791307—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,578
Classify the chromosome 15 variant at position 34791307 affecting gene ACTC1 as benign or pathogenic. If pathogenic, which disease(s) is associated?
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,579
Benign or pathogenic: chromosome 15, position 34791307, gene ACTC1 variant? Disease(s) if pathogenic?
benign
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
AATTCATCAGCACCTACCAGCCTGCCCCATGTCTTGTATCCTGGCTTCTGCCACACTTCCTTCTGCTGAGATGTCCTCTCTGCTCTTCTCACCTCCCTAATTCCTGACCATTCTCTAAGACCCAGACCCACATACATCTCCTTAAAGCCTCCAGGCCACACGCACTGGGGGATTATGTGTAGGTGTGTGAACTCCTCGAGGATGGAACACATTCAATTCTTTTCAACGCTGCCCCTAGCAGCCTTCCCACCATACTTTGCAGAGAGCTCTGCACAGAGCAAAGCAAACACTGTGGCTCTCGCCTCCCCTTGCTCCCTCAG...
benign
229,580
Variant in gene ACTC1, located at chromosome 15 position 34792393: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
TTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTA...
TTTGGAAGACTCCAAGAAGCATAATACCGTCATCCTGACTGGAAGGTAGATGGAGAGAGAAGGCATCTTAGAAGCATTTGCGGTGGACAATGGATGGGCCTGCCTCATCGTACTCTTGCTTGCTAATCCACATTTGCTGGAAGGTGGACAGAGAGGCCAGGATGGAGCCCCCAATCCAGACAGAGTATTTACGCTCAGGGGGAGCAATAATCTGCAGAAAGAAAACAAAAACTTCCAGTGAACTCTGAAGTTCCAAGCAAGGGAGCAAATAACACATTGGGAGGATTCACAGAAAAAAACCATTAGATATTAATTCGCTA...
benign
229,601
Mutation found at chromosome 15 position 34793421, gene ACTC1: benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Hypertrophic_cardiomyopathy_11']
AGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTT...
AGGTAGAGGGAAGAGAACAGAACTTCTTTGTGTGGGGGAGCTGTCACCATTTGTCTCTGAAACATATGTTCCCCTATAAGACACACTGCAGGGTGGAATGGGTGCCTCACAGTTAATCCACAATACAATGCCAAGAAAGGAGCAACTGTGCTTAGCACCTGTTTCAAGTAAACACCTCCTGAAACTCTCAGATGTATGAAGATGTATTGGAAAAGGAAAAGATACACGTTTAAACTAAAATGAATGTAATTTTTGTTTATGGACTTAAATCAGATCCTGACAAAGTTCCTTATGGAAAGCATTGCTTAGGAAGGATATTT...
pathogenic
229,643
A genetic variant on chromosome 15, position 34794656, affects the gene ACTC1. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
benign
AGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATG...
AGGACAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATG...
benign
229,657
Benign or pathogenic: chromosome 15, position 34794660, gene ACTC1 variant? Disease(s) if pathogenic?
benign
CAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATT...
CAACACCACTGCTCTAGCCACGGCAAAGCCCGCTTCCAATCTTGGCTAAGAGATGCTAGCAATGGGCATTGATCCAGATAAAATTAGATTCCTTACACACAAAGAATAAAAATGCGCATCAGGAATACTAAATCTGAAGCAAACTGCAGCTCATCTTTTTAACTATTATAGTAGAAAAAATTCCCGAGGACACTTTCAAATGACCATCTTTCTTGTCAGCCACGAGCACATTATGTAAGCACCCAAGGGTGTTTTTCTTTGCTCCTATTGAACTTACACGTTTCTCTCTCTTTTGACTCAGACCCTGTATGGAATGTATT...
benign
229,658
Does the variant on chromosome 15 at location 36896663 affecting gene MEIS2 (Meis homeobox 2) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Cardiac_malformation,_cleft_lip/palate,_microcephaly,_and_digital_anomalies', 'Cleft_palate', 'Inborn_genetic_diseases', 'MEIS2-related_disorder']
TGCAGTTATGGGCAAGGAAAAATAAAATGGGGGCAAATTATAAAAAATAAAATAAAGTCTCTGAAGTGATAGTGAAGACAGATCGCACCCGACTGTACTTACTTCCCCCTTGCTTTGCGATTGCTTTACATGATGAAGGTTACATGTAGTGCCATTGCCCATCCATGCCCATATTCATGCCCATTCCACTCATAGGTCCTAGAAAGGAGATAAAATCCAAGAAGAGGCCGGAAAATCAGCAATAATTGATGGTGAAAAAATAGAAGGAAACTCAGATTCCTTTTCACTTATTGCCTTGGTTTAAAAAGAAAAAAGAAAAA...
TGCAGTTATGGGCAAGGAAAAATAAAATGGGGGCAAATTATAAAAAATAAAATAAAGTCTCTGAAGTGATAGTGAAGACAGATCGCACCCGACTGTACTTACTTCCCCCTTGCTTTGCGATTGCTTTACATGATGAAGGTTACATGTAGTGCCATTGCCCATCCATGCCCATATTCATGCCCATTCCACTCATAGGTCCTAGAAAGGAGATAAAATCCAAGAAGAGGCCGGAAAATCAGCAATAATTGATGGTGAAAAAATAGAAGGAAACTCAGATTCCTTTTCACTTATTGCCTTGGTTTAAAAAGAAAAAAGAAAAA...
pathogenic
229,702
Benign or pathogenic: chromosome 15, position 36950363, gene MEIS2 (Meis homeobox 2) variant? Disease(s) if pathogenic?
pathogenic; ['Cardiac_malformation,_cleft_lip/palate,_microcephaly,_and_digital_anomalies', 'Inborn_genetic_diseases']
CTTGGGGCTCAATGGAATTCAGAAAGGAAGGGTGTTCTTTCCAGTTCCAGCCAGGTGTCTAATTGTGGGAAATGCTAGATTGTAGATTCTAAAAATTCTTCATTCTTCAGGTGCGAAGAGTATATCAAAAACTATAGGTAATGGATGATAAGGAACAGTATTTTCAAAAAGAACAAGATCAAATATCAATGCCAAATATCCATGCGGAAATTTTATTTTTCTCAGAAATTCCCATCACAAGCTCCCTCAATTGCCTCAAATGTACAAAAATTATGATTCTAAAGCAATGTTAACTGCGTCATGGACCAATGTGTATATAT...
CTTGGGGCTCAATGGAATTCAGAAAGGAAGGGTGTTCTTTCCAGTTCCAGCCAGGTGTCTAATTGTGGGAAATGCTAGATTGTAGATTCTAAAAATTCTTCATTCTTCAGGTGCGAAGAGTATATCAAAAACTATAGGTAATGGATGATAAGGAACAGTATTTTCAAAAAGAACAAGATCAAATATCAATGCCAAATATCCATGCGGAAATTTTATTTTTCTCAGAAATTCCCATCACAAGCTCCCTCAATTGCCTCAAATGTACAAAAATTATGATTCTAAAGCAATGTTAACTGCGTCATGGACCAATGTGTATATAT...
pathogenic
229,703
Chromosome 15, position 37036932, gene MEIS2 (Meis homeobox 2): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Cardiac_malformation,_cleft_lip/palate,_microcephaly,_and_digital_anomalies']
GCCCTTGTCTCAGCTTGACCTTCAGCTAGTAACTTCCCTTTTTGGGTCTCTGTTTCCTCATCTATAAACAGAGCAGCTGCATTCTCTAAGGTTCTACTGTTCTCTGACATTGGTTTTGATGACAGAGAGGTTGAAAACACACGTAGCTGTTTGCTTGGAAAGCAGCTGTTGAAGTGTTTATTTTCGACCAAGAAAGACCAAGCATGGAGGAGGACAGAGGGAGGGAACCAAACAGGTGAGCTGGTCAGGAGAAGGCAGCTGGCCTGTCATCCGCAGCTACACTGCCGTTCTTAGTTGCTACTCTAACCAAACAAACCTTC...
GCCCTTGTCTCAGCTTGACCTTCAGCTAGTAACTTCCCTTTTTGGGTCTCTGTTTCCTCATCTATAAACAGAGCAGCTGCATTCTCTAAGGTTCTACTGTTCTCTGACATTGGTTTTGATGACAGAGAGGTTGAAAACACACGTAGCTGTTTGCTTGGAAAGCAGCTGTTGAAGTGTTTATTTTCGACCAAGAAAGACCAAGCATGGAGGAGGACAGAGGGAGGGAACCAAACAGGTGAGCTGGTCAGGAGAAGGCAGCTGGCCTGTCATCCGCAGCTACACTGCCGTTCTTAGTTGCTACTCTAACCAAACAAACCTTC...
pathogenic
229,705
Benign or pathogenic: chromosome 15, position 38322261, gene SPRED1 (sprouty related EVH1 domain containing 1) variant? Disease(s) if pathogenic?
pathogenic; ['Cardiovascular_phenotype', 'Legius_syndrome']
AGCAGACTCTAGCAGACCTCCCCTCCAAAAGTATAAATTAGAGATTCCTAGTCCATGATCTGTGAATGAGTTCCTTGGGAAGTGCATAAAGCCTAAAAGATTTCTGAGGAGAAGTATTGGTTGAGTACCTAATGTTTGTCTGCCACTGTAGTTTAAGGATTTGGCAAACAGACAAAGACCAGCTCATGCAGGGCCTAGTAGGTCATAGTAAGAATTTTAGTCTTGAAAGCATTGAAAAGACATTGAAACTAGGGAGTGGTCCAGTAAAGTTGCTATTTTTTTTTAAGAAAAATTATTACTCTACCTGCAGAGTAGTGCAA...
AGCAGACTCTAGCAGACCTCCCCTCCAAAAGTATAAATTAGAGATTCCTAGTCCATGATCTGTGAATGAGTTCCTTGGGAAGTGCATAAAGCCTAAAAGATTTCTGAGGAGAAGTATTGGTTGAGTACCTAATGTTTGTCTGCCACTGTAGTTTAAGGATTTGGCAAACAGACAAAGACCAGCTCATGCAGGGCCTAGTAGGTCATAGTAAGAATTTTAGTCTTGAAAGCATTGAAAAGACATTGAAACTAGGGAGTGGTCCAGTAAAGTTGCTATTTTTTTTTAAGAAAAATTATTACTCTACCTGCAGAGTAGTGCAA...
pathogenic
229,737
A genetic variant on chromosome 15, position 38322336, affects the gene SPRED1 (sprouty related EVH1 domain containing 1). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Legius_syndrome', 'Noonan_syndrome_and_Noonan-related_syndrome']
TGGGAAGTGCATAAAGCCTAAAAGATTTCTGAGGAGAAGTATTGGTTGAGTACCTAATGTTTGTCTGCCACTGTAGTTTAAGGATTTGGCAAACAGACAAAGACCAGCTCATGCAGGGCCTAGTAGGTCATAGTAAGAATTTTAGTCTTGAAAGCATTGAAAAGACATTGAAACTAGGGAGTGGTCCAGTAAAGTTGCTATTTTTTTTTAAGAAAAATTATTACTCTACCTGCAGAGTAGTGCAATTACTATTAGTAATTCACTACTACTAGTAATATCTGAGGGGATCATCAGCAGTGCATGGAAGAGATGTGCAAGTG...
TGGGAAGTGCATAAAGCCTAAAAGATTTCTGAGGAGAAGTATTGGTTGAGTACCTAATGTTTGTCTGCCACTGTAGTTTAAGGATTTGGCAAACAGACAAAGACCAGCTCATGCAGGGCCTAGTAGGTCATAGTAAGAATTTTAGTCTTGAAAGCATTGAAAAGACATTGAAACTAGGGAGTGGTCCAGTAAAGTTGCTATTTTTTTTTAAGAAAAATTATTACTCTACCTGCAGAGTAGTGCAATTACTATTAGTAATTCACTACTACTAGTAATATCTGAGGGGATCATCAGCAGTGCATGGAAGAGATGTGCAAGTG...
pathogenic
229,742
Clinical impact (benign or pathogenic) of the variant at chromosome 15, location 38322357, gene SPRED1 (sprouty related EVH1 domain containing 1): what disease(s) if pathogenic?
pathogenic; ['Legius_syndrome']
AAGATTTCTGAGGAGAAGTATTGGTTGAGTACCTAATGTTTGTCTGCCACTGTAGTTTAAGGATTTGGCAAACAGACAAAGACCAGCTCATGCAGGGCCTAGTAGGTCATAGTAAGAATTTTAGTCTTGAAAGCATTGAAAAGACATTGAAACTAGGGAGTGGTCCAGTAAAGTTGCTATTTTTTTTTAAGAAAAATTATTACTCTACCTGCAGAGTAGTGCAATTACTATTAGTAATTCACTACTACTAGTAATATCTGAGGGGATCATCAGCAGTGCATGGAAGAGATGTGCAAGTGATAATGGTGATTGGAAAAGAG...
AAGATTTCTGAGGAGAAGTATTGGTTGAGTACCTAATGTTTGTCTGCCACTGTAGTTTAAGGATTTGGCAAACAGACAAAGACCAGCTCATGCAGGGCCTAGTAGGTCATAGTAAGAATTTTAGTCTTGAAAGCATTGAAAAGACATTGAAACTAGGGAGTGGTCCAGTAAAGTTGCTATTTTTTTTTAAGAAAAATTATTACTCTACCTGCAGAGTAGTGCAATTACTATTAGTAATTCACTACTACTAGTAATATCTGAGGGGATCATCAGCAGTGCATGGAAGAGATGTGCAAGTGATAATGGTGATTGGAAAAGAG...
pathogenic
229,745
Located at chromosome 15 position 38324775, the variant affecting gene SPRED1 (sprouty related EVH1 domain containing 1)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Legius_syndrome']
TCCCAGTTGGTATTCTACTTGTGTATGTATGACACCAGTCACATCCTTTTTTTGGGTAATTATATAGAACTTGTAATATTCAAATGTATGTAGACTCTAGTTATTCCATGACAAAAGTCTTTACTTGATTGATTTCATTATTGAGGATTGGCAGAGACCACAAGCTCATCTATTCCTTTGTTATCTTGCCAGTCTATTAAAATTATTAACTCAAAAGCATACAGGTTTTGAAGGGAAGAATAATGTTTTTTCATGTAAGACTGGCTTATGCTTACTTAAACAAAAATCACATTAAAACCCATTTCTTCCCATAAAGGAAG...
TCCCAGTTGGTATTCTACTTGTGTATGTATGACACCAGTCACATCCTTTTTTTGGGTAATTATATAGAACTTGTAATATTCAAATGTATGTAGACTCTAGTTATTCCATGACAAAAGTCTTTACTTGATTGATTTCATTATTGAGGATTGGCAGAGACCACAAGCTCATCTATTCCTTTGTTATCTTGCCAGTCTATTAAAATTATTAACTCAAAAGCATACAGGTTTTGAAGGGAAGAATAATGTTTTTTCATGTAAGACTGGCTTATGCTTACTTAAACAAAAATCACATTAAAACCCATTTCTTCCCATAAAGGAAG...
pathogenic
229,753
Chromosome 15, position 38349572, gene SPRED1 (sprouty related EVH1 domain containing 1): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
benign
GCTTGTCAAATCTGATGAAGAATCCTTTTGTGGTTTATATTTGAATTGCGCTGAATGTGTGTGTTAGTTTAGGGGATAATTTATCATCTTATTCGTGAATATGATATATACCTCTGTTTAGCTCTTCTTCTGTATCTTTACATAAAACTTTGTATTTTCTTTGTGAAAAGATAATACATATTTTATAGGATTATTTCTTTGTACCATTTTTGTTGTTCTATTATAAATGGAATCCTTTTAAAATTTTAATTGTGACCAGCTTTGAAGAAGCATCTCTTATGACTTTTTCAGCTGATAAATTTTCCTGAAGATTATAGCAA...
GCTTGTCAAATCTGATGAAGAATCCTTTTGTGGTTTATATTTGAATTGCGCTGAATGTGTGTGTTAGTTTAGGGGATAATTTATCATCTTATTCGTGAATATGATATATACCTCTGTTTAGCTCTTCTTCTGTATCTTTACATAAAACTTTGTATTTTCTTTGTGAAAAGATAATACATATTTTATAGGATTATTTCTTTGTACCATTTTTGTTGTTCTATTATAAATGGAATCCTTTTAAAATTTTAATTGTGACCAGCTTTGAAGAAGCATCTCTTATGACTTTTTCAGCTGATAAATTTTCCTGAAGATTATAGCAA...
benign
229,781
Variant chromosome 15, position 38351124, gene SPRED1 (sprouty related EVH1 domain containing 1): benign or pathogenic? Disease(s)?
pathogenic; ['Cardiovascular_phenotype', 'Legius_syndrome', 'Noonan_syndrome_and_Noonan-related_syndrome']
ATTATTGTGACATGTGTAACTACTTTATTTCTCTTTGTGGTTGAATAATATTCCACTCTATGGATTTACTACATTTTGTTTATCCGTTCATTAGTTGATGAATATTTGGGTTGTTTGTACTTTTTTGACTATGTATTCATTACTTGTTAAAGTTTAAATATGTAAGAAAAGACCTATGGTTTTTGTTTGTGTTTTAGGTGGGGGGAAATGATTCTATTTTTATTCTCAAAACCGTTTTTGAAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCAT...
ATTATTGTGACATGTGTAACTACTTTATTTCTCTTTGTGGTTGAATAATATTCCACTCTATGGATTTACTACATTTTGTTTATCCGTTCATTAGTTGATGAATATTTGGGTTGTTTGTACTTTTTTGACTATGTATTCATTACTTGTTAAAGTTTAAATATGTAAGAAAAGACCTATGGTTTTTGTTTGTGTTTTAGGTGGGGGGAAATGATTCTATTTTTATTCTCAAAACCGTTTTTGAAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCAT...
pathogenic
229,787
Gene SPRED1 (sprouty related EVH1 domain containing 1) variant at chromosome position 38351190 on chromosome 15: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Legius_syndrome']
TACTACATTTTGTTTATCCGTTCATTAGTTGATGAATATTTGGGTTGTTTGTACTTTTTTGACTATGTATTCATTACTTGTTAAAGTTTAAATATGTAAGAAAAGACCTATGGTTTTTGTTTGTGTTTTAGGTGGGGGGAAATGATTCTATTTTTATTCTCAAAACCGTTTTTGAAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCATTTAAGTAGAAATTGTTTGTATTTTAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAA...
TACTACATTTTGTTTATCCGTTCATTAGTTGATGAATATTTGGGTTGTTTGTACTTTTTTGACTATGTATTCATTACTTGTTAAAGTTTAAATATGTAAGAAAAGACCTATGGTTTTTGTTTGTGTTTTAGGTGGGGGGAAATGATTCTATTTTTATTCTCAAAACCGTTTTTGAAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCATTTAAGTAGAAATTGTTTGTATTTTAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAA...
pathogenic
229,788
Clinical classification of chromosome 15, position 38351228, gene SPRED1 (sprouty related EVH1 domain containing 1): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Legius_syndrome']
TTTGGGTTGTTTGTACTTTTTTGACTATGTATTCATTACTTGTTAAAGTTTAAATATGTAAGAAAAGACCTATGGTTTTTGTTTGTGTTTTAGGTGGGGGGAAATGATTCTATTTTTATTCTCAAAACCGTTTTTGAAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCATTTAAGTAGAAATTGTTTGTATTTTAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGT...
TTTGGGTTGTTTGTACTTTTTTGACTATGTATTCATTACTTGTTAAAGTTTAAATATGTAAGAAAAGACCTATGGTTTTTGTTTGTGTTTTAGGTGGGGGGAAATGATTCTATTTTTATTCTCAAAACCGTTTTTGAAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCATTTAAGTAGAAATTGTTTGTATTTTAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGT...
pathogenic
229,793
Variant in gene SPRED1 (sprouty related EVH1 domain containing 1), located at chromosome 15 position 38351230: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Legius_syndrome']
TGGGTTGTTTGTACTTTTTTGACTATGTATTCATTACTTGTTAAAGTTTAAATATGTAAGAAAAGACCTATGGTTTTTGTTTGTGTTTTAGGTGGGGGGAAATGATTCTATTTTTATTCTCAAAACCGTTTTTGAAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCATTTAAGTAGAAATTGTTTGTATTTTAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGG...
TGGGTTGTTTGTACTTTTTTGACTATGTATTCATTACTTGTTAAAGTTTAAATATGTAAGAAAAGACCTATGGTTTTTGTTTGTGTTTTAGGTGGGGGGAAATGATTCTATTTTTATTCTCAAAACCGTTTTTGAAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCATTTAAGTAGAAATTGTTTGTATTTTAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGG...
pathogenic
229,794
Clinical significance of chromosome 15, position 38351364, gene SPRED1 (sprouty related EVH1 domain containing 1): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Legius_syndrome', 'Noonan_syndrome_and_Noonan-related_syndrome']
AAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCATTTAAGTAGAAATTGTTTGTATTTTAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGGAAGCCTAAAGTCCCAAAATAGGGTAAGTAATGTTAGTTTATCTTGTGATATGGAATTTAACTAATTAATAGATAGGTAAAGTTTTCCAGTCTTTCTAATTCTCCATATAGTTGAATTGTACTAGAAAATTTTTC...
AAAAACTTTACTGCTAATAAATTATGAGGTTTTGGAACATACACTGTACAGTTTCATTAAAAGTAAAATTCTTGTGTCATTTAAGTAGAAATTGTTTGTATTTTAGATAACATTTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGGAAGCCTAAAGTCCCAAAATAGGGTAAGTAATGTTAGTTTATCTTGTGATATGGAATTTAACTAATTAATAGATAGGTAAAGTTTTCCAGTCTTTCTAATTCTCCATATAGTTGAATTGTACTAGAAAATTTTTC...
pathogenic
229,803
Chromosome 15, position 38351477, gene SPRED1 (sprouty related EVH1 domain containing 1): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Legius_syndrome']
TTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGGAAGCCTAAAGTCCCAAAATAGGGTAAGTAATGTTAGTTTATCTTGTGATATGGAATTTAACTAATTAATAGATAGGTAAAGTTTTCCAGTCTTTCTAATTCTCCATATAGTTGAATTGTACTAGAAAATTTTTCATTGTATAAATTTGCTGCCTATGTGCTTAAACGCTGTTAGTTAAAAACTCTGCAAACTTCTCATTTGAGTCTAAAAGATTGCCAGAGCTGCATTTATTAGATAGGACCAAAAG...
TTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGGAAGCCTAAAGTCCCAAAATAGGGTAAGTAATGTTAGTTTATCTTGTGATATGGAATTTAACTAATTAATAGATAGGTAAAGTTTTCCAGTCTTTCTAATTCTCCATATAGTTGAATTGTACTAGAAAATTTTTCATTGTATAAATTTGCTGCCTATGTGCTTAAACGCTGTTAGTTAAAAACTCTGCAAACTTCTCATTTGAGTCTAAAAGATTGCCAGAGCTGCATTTATTAGATAGGACCAAAAG...
pathogenic
229,810
Evaluate the clinical significance of the mutation at chromosome 15, position 38351477 in gene SPRED1 (sprouty related EVH1 domain containing 1): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Cardiovascular_phenotype', 'Legius_syndrome']
TTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGGAAGCCTAAAGTCCCAAAATAGGGTAAGTAATGTTAGTTTATCTTGTGATATGGAATTTAACTAATTAATAGATAGGTAAAGTTTTCCAGTCTTTCTAATTCTCCATATAGTTGAATTGTACTAGAAAATTTTTCATTGTATAAATTTGCTGCCTATGTGCTTAAACGCTGTTAGTTAAAAACTCTGCAAACTTCTCATTTGAGTCTAAAAGATTGCCAGAGCTGCATTTATTAGATAGGACCAAAAG...
TTGGTCAGCCAGGCTTGGACATTCAGAGCAGAAGTATGGAATACGTACAGCGGCAAATATCCAAGGAATGTGGAAGCCTAAAGTCCCAAAATAGGGTAAGTAATGTTAGTTTATCTTGTGATATGGAATTTAACTAATTAATAGATAGGTAAAGTTTTCCAGTCTTTCTAATTCTCCATATAGTTGAATTGTACTAGAAAATTTTTCATTGTATAAATTTGCTGCCTATGTGCTTAAACGCTGTTAGTTAAAAACTCTGCAAACTTCTCATTTGAGTCTAAAAGATTGCCAGAGCTGCATTTATTAGATAGGACCAAAAG...
pathogenic
229,811
Regarding the variant found on chromosome 15 at position 39953947 in gene EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4): is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Familial_pulmonary_capillary_hemangiomatosis']
ATCTTAACTGCTTACCTATACTACGTTCTATTTGTCAATGATCTGTTCAACTCATCTGTTTTTTCTTGAATCTCTACCACACTCTTTGAATTATTGTATCTTTATAATGCTTTAATATCTGACAAGTCAATCCTACCCCTCCCCATCCCTTCATCTTCCATTGTTTTTGTTTCTCAGCCATTCTCACCCATTTATTCTTACAGAAGATGTACAGAATTACTTTCCCATAGTCAAAACAAAACAAACATCCTGGGATTTTTATTGATTTTAAAAAATCTTACATATTTATTTAGGAAGAATTGATATCTTCACAGTATTTA...
ATCTTAACTGCTTACCTATACTACGTTCTATTTGTCAATGATCTGTTCAACTCATCTGTTTTTTCTTGAATCTCTACCACACTCTTTGAATTATTGTATCTTTATAATGCTTTAATATCTGACAAGTCAATCCTACCCCTCCCCATCCCTTCATCTTCCATTGTTTTTGTTTCTCAGCCATTCTCACCCATTTATTCTTACAGAAGATGTACAGAATTACTTTCCCATAGTCAAAACAAAACAAACATCCTGGGATTTTTATTGATTTTAAAAAATCTTACATATTTATTTAGGAAGAATTGATATCTTCACAGTATTTA...
pathogenic
229,881
Regarding the variant at chromosome 15 and position 39967716, affecting gene EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Familial_pulmonary_capillary_hemangiomatosis']
TTTCTGTTTAATGTGCAGGCAGTGATGAACAACTTGGAAAATTAGTCTACAATGCTTTGGAAACAGCCACTGGTGGCTTTGTCTTGTTGTATGAGTGGGTCCTTCAGTGGCAGAAAAAAATGGGTCCATTCCTTACCAGTCAAGAAAAAGAGAAGATTGATAAGTGCAAAAAGCAGGTAAGCATCCAAGGTGGCTGACTGAGCAAAAGGCCTAATCTCAGGCTTTAGGAGATGACAGAACAAAATAGCCCTGCATTTGTTTGCCCTGCAGAGATGGTCCAGAGCAGTATGAGAACTGTTTGACCAGGGAGGACAGTGAAG...
TTTCTGTTTAATGTGCAGGCAGTGATGAACAACTTGGAAAATTAGTCTACAATGCTTTGGAAACAGCCACTGGTGGCTTTGTCTTGTTGTATGAGTGGGTCCTTCAGTGGCAGAAAAAAATGGGTCCATTCCTTACCAGTCAAGAAAAAGAGAAGATTGATAAGTGCAAAAAGCAGGTAAGCATCCAAGGTGGCTGACTGAGCAAAAGGCCTAATCTCAGGCTTTAGGAGATGACAGAACAAAATAGCCCTGCATTTGTTTGCCCTGCAGAGATGGTCCAGAGCAGTATGAGAACTGTTTGACCAGGGAGGACAGTGAAG...
pathogenic
229,889
Clinically, how would you classify the variant at chromosome 15, position 39976797, gene EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4): benign or pathogenic? If pathogenic, specify the associated illness(es).
benign
AACAAAAACATCTGAGTAACTTAAGCCCCCACGGTTTCCAGTAGTTTCTCCCTGTGAGAATCCACAGCCCTCACCTCCTACCTCTGTGCTTCTGTGTCAGAGTAGGGCAGCCTGCCCAGTGATCTGGCATTCATTAGCAGTTGGACCCATTACTGTTTCTGCACCTTTTCACTTCAGTAAATGAATTCCTAGGGGTTTCCAGTATAGCAAGCTTTACTCCCAACCCAGTTCGTATATGATGTGTACTGAGACAGGAGATCGAAAGGCAATGCCAAGATCCCCACCTCCCGCCCTACACTGTCCTCTTCCCTATTAATGTG...
AACAAAAACATCTGAGTAACTTAAGCCCCCACGGTTTCCAGTAGTTTCTCCCTGTGAGAATCCACAGCCCTCACCTCCTACCTCTGTGCTTCTGTGTCAGAGTAGGGCAGCCTGCCCAGTGATCTGGCATTCATTAGCAGTTGGACCCATTACTGTTTCTGCACCTTTTCACTTCAGTAAATGAATTCCTAGGGGTTTCCAGTATAGCAAGCTTTACTCCCAACCCAGTTCGTATATGATGTGTACTGAGACAGGAGATCGAAAGGCAATGCCAAGATCCCCACCTCCCGCCCTACACTGTCCTCTTCCCTATTAATGTG...
benign
229,901
Is the genetic variant on chromosome 15, position 40006999, gene EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4), benign or pathogenic? If pathogenic, what disease(s) is indicated?
benign
CCACGTATCCAGCCAACTGTGGATGGAAAATACTCAGAAAAAAAAATTCCAACAAGCAAAATTTGAATTTACCATGTGCTAAACACTGCATTGAATCCACACAAAAGAAGGGATGTATAGGCATAGTAGTAGATATTATAAGTAATCTAAAGATGATTTAAAGTGTACAGGAGGATGCGCATAGGCTATAGGCAAATGCTCTGTCATTTTATATCAGGAACTTAACCATCCACTGATTTTGGTATCCTTGGGGGAGTCCCGGAACCAATTTCTGAGGGACAACTATACATATTTAGATATAGCCATATTTATACTTGATT...
CCACGTATCCAGCCAACTGTGGATGGAAAATACTCAGAAAAAAAAATTCCAACAAGCAAAATTTGAATTTACCATGTGCTAAACACTGCATTGAATCCACACAAAAGAAGGGATGTATAGGCATAGTAGTAGATATTATAAGTAATCTAAAGATGATTTAAAGTGTACAGGAGGATGCGCATAGGCTATAGGCAAATGCTCTGTCATTTTATATCAGGAACTTAACCATCCACTGATTTTGGTATCCTTGGGGGAGTCCCGGAACCAATTTCTGAGGGACAACTATACATATTTAGATATAGCCATATTTATACTTGATT...
benign
229,923
Variant on chromosome 15, at position 40020929, affecting EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Familial_pulmonary_capillary_hemangiomatosis']
AACAGTGCAGAGTTAGATGAAACATTTGTTAATATTTTTTCTAAATTTGCATGTGTGCTTGCTTCTCTATTTTACTACACACACACATTTCTTTTTGTTGAACTCTTTGATGATGAGCTGCTGACAGAGTGCTCACTCTTTAATCATTGTTTTCCCCGTAATCACAGTTTCTTTCCTATTTCATAACCATAACTGTTTGTGTCTCTCCACAGATTCCCCAGTTTAGAGGGCCACAAGCTCTGGGGCCAGTTCCCACTGCCATTGGGGTCAGCATAGCTATAGACAAGATATCTGCTGCTGTCCTCAACATGGAGGAATCT...
AACAGTGCAGAGTTAGATGAAACATTTGTTAATATTTTTTCTAAATTTGCATGTGTGCTTGCTTCTCTATTTTACTACACACACACATTTCTTTTTGTTGAACTCTTTGATGATGAGCTGCTGACAGAGTGCTCACTCTTTAATCATTGTTTTCCCCGTAATCACAGTTTCTTTCCTATTTCATAACCATAACTGTTTGTGTCTCTCCACAGATTCCCCAGTTTAGAGGGCCACAAGCTCTGGGGCCAGTTCCCACTGCCATTGGGGTCAGCATAGCTATAGACAAGATATCTGCTGCTGTCCTCAACATGGAGGAATCT...
pathogenic
229,938
Clinical classification of chromosome 15, position 40035006, gene EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4): benign or pathogenic? Disease(s) if pathogenic?
benign
TCCTAAATCCTATGTTGAAGGACTCATACTTTTCTAGTGACTTTATTTTTCAGATACTTATTTTATTAAAAACAAAAAACAAAAACAAAAAAACACATATACTGCTTTTACTATGTGTCAGGGTCTGGCAGGCCTTGTTGTAAGCATTTTACAAGTAGTAACTCATTTAATCATTACCACCCCAAAATGTAGATACTGTTATTATCCCTTTACAGAGTACGGAAGTAGAGAGGTTAAATATCTTACCCACAGTCACCCAGCTAGTAAGTAGTAGAACCAGGATTTGAACCTAAGCAGACTAGCAGAATCGGTGTTCTTAA...
TCCTAAATCCTATGTTGAAGGACTCATACTTTTCTAGTGACTTTATTTTTCAGATACTTATTTTATTAAAAACAAAAAACAAAAACAAAAAAACACATATACTGCTTTTACTATGTGTCAGGGTCTGGCAGGCCTTGTTGTAAGCATTTTACAAGTAGTAACTCATTTAATCATTACCACCCCAAAATGTAGATACTGTTATTATCCCTTTACAGAGTACGGAAGTAGAGAGGTTAAATATCTTACCCACAGTCACCCAGCTAGTAAGTAGTAGAACCAGGATTTGAACCTAAGCAGACTAGCAGAATCGGTGTTCTTAA...
benign
229,956
Gene mutation in BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) at chromosome 15, position 40165037—is it benign or pathogenic? If pathogenic, specify the disease(s).
benign
TGCGGGGCTGCTGTGTATGTGGAGTTTTCATGTTTTCCGCATGTCTGCATGGGTTTCCTTAGGTACTCCAGTTTCCTTCTACATCCCAAAGATGTGCCTGTTAATTGGCGTGTCTAAATGATCCCAGTCTGAATGGGTGTGAATGTGATGCTCCCTGTGATGGAGTGGTGTCCTGTCCAGGGTTGGTTCCTCTCTGAGTTGCTGAGATGGGCTCTGGCCACCCTCAACCCCGAACTAGAATAAGTGAGTTGGAAAATGAATGAAGGAATGAATACAAATTACTGTAAAATAAAAATCTGTAAAGGCTGGGAGCGGTGGCT...
TGCGGGGCTGCTGTGTATGTGGAGTTTTCATGTTTTCCGCATGTCTGCATGGGTTTCCTTAGGTACTCCAGTTTCCTTCTACATCCCAAAGATGTGCCTGTTAATTGGCGTGTCTAAATGATCCCAGTCTGAATGGGTGTGAATGTGATGCTCCCTGTGATGGAGTGGTGTCCTGTCCAGGGTTGGTTCCTCTCTGAGTTGCTGAGATGGGCTCTGGCCACCCTCAACCCCGAACTAGAATAAGTGAGTTGGAAAATGAATGAAGGAATGAATACAAATTACTGTAAAATAAAAATCTGTAAAGGCTGGGAGCGGTGGCT...
benign
229,975
Chromosome 15, position 40170539, gene BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Colorectal_cancer', 'Mosaic_variegated_aneuploidy_syndrome_1', 'Premature_chromatid_separation_trait']
TTGTTTTACCATTTCTGCAGATAATCTCATTATTTCACACTTTAATTGCCATATTAGCCTCATAACTGTGGTCCCTTCTTCTAATGCCTGGCTATCCTTATAAAGTTGCTTGATTAATCTTTCTGAAATCTTATATTTAAGATGCCCTCCAATTAAAGAACCAATAGTGGCTGGAGTAGATGGAATCCAAAGTCTTTAAATTTACATTTAAAGCATGTGCTTCTTACTTCTCCAGGGGTCTCCATTTGCTCTCGGTACTGACTTTATGTTATAGCTTAGGGTTCACTCACCTTCCTTTGGATGAGCTCTTCCACCTTCGT...
TTGTTTTACCATTTCTGCAGATAATCTCATTATTTCACACTTTAATTGCCATATTAGCCTCATAACTGTGGTCCCTTCTTCTAATGCCTGGCTATCCTTATAAAGTTGCTTGATTAATCTTTCTGAAATCTTATATTTAAGATGCCCTCCAATTAAAGAACCAATAGTGGCTGGAGTAGATGGAATCCAAAGTCTTTAAATTTACATTTAAAGCATGTGCTTCTTACTTCTCCAGGGGTCTCCATTTGCTCTCGGTACTGACTTTATGTTATAGCTTAGGGTTCACTCACCTTCCTTTGGATGAGCTCTTCCACCTTCGT...
pathogenic
229,988
The mutation in gene BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B) at chromosome 15, position 40210151—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Inborn_genetic_diseases']
GAATGAGATCCTGTCTCAAAAATAAAATGAAAAGTAAAAAAAAAAAATGAGGCTATCAAATAAATTGATAACAAATTATAAATTATTTAAACCTAAATTTTATTGTGTTAAAAAATAAAAGAATAACATAAAATTATAAAATGTGTACATTAAGGCCAGGTGCAGTGGCTCACGCCTATAATCCCAGCACTTTAGGAGGCTGAGACGGGTGGACCATCTGAAGTCAGGAGTTCAAGACCAGTCTGGCTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATCAGCTGGGCATGGTGGCAGGTGCCTGTAATCCC...
GAATGAGATCCTGTCTCAAAAATAAAATGAAAAGTAAAAAAAAAAAATGAGGCTATCAAATAAATTGATAACAAATTATAAATTATTTAAACCTAAATTTTATTGTGTTAAAAAATAAAAGAATAACATAAAATTATAAAATGTGTACATTAAGGCCAGGTGCAGTGGCTCACGCCTATAATCCCAGCACTTTAGGAGGCTGAGACGGGTGGACCATCTGAAGTCAGGAGTTCAAGACCAGTCTGGCTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATCAGCTGGGCATGGTGGCAGGTGCCTGTAATCCC...
pathogenic
230,099
Assess the variant on chromosome 15, position 40210185, impacting BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Mosaic_variegated_aneuploidy_syndrome_1']
TAAAAAAAAAAAATGAGGCTATCAAATAAATTGATAACAAATTATAAATTATTTAAACCTAAATTTTATTGTGTTAAAAAATAAAAGAATAACATAAAATTATAAAATGTGTACATTAAGGCCAGGTGCAGTGGCTCACGCCTATAATCCCAGCACTTTAGGAGGCTGAGACGGGTGGACCATCTGAAGTCAGGAGTTCAAGACCAGTCTGGCTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATCAGCTGGGCATGGTGGCAGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTT...
TAAAAAAAAAAAATGAGGCTATCAAATAAATTGATAACAAATTATAAATTATTTAAACCTAAATTTTATTGTGTTAAAAAATAAAAGAATAACATAAAATTATAAAATGTGTACATTAAGGCCAGGTGCAGTGGCTCACGCCTATAATCCCAGCACTTTAGGAGGCTGAGACGGGTGGACCATCTGAAGTCAGGAGTTCAAGACCAGTCTGGCTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATCAGCTGGGCATGGTGGCAGGTGCCTGTAATCCCAGCTACTCAGGAGGCTGAGACAGGAGAATCACTT...
pathogenic
230,103
Evaluate this variant at chromosome 15, position 40218473, gene BUB1B: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Mosaic_variegated_aneuploidy_syndrome_1']
TGTAGACCTTGTCTAAGAAACCAAACAAAACACACACATGCACACACTTTACATATATATATAAAATACATATGTATATTTTATATATATCAGAATCCACGATCCCTATAACTATATATATACTATATATATATATATATATATATATTTTTTTTTTTTTTTAATTATAGTATAGTTTTATGGTGGCCAAAAAAGGTTGGCTCTTGTGCCAAGGAAAAATGAGAGCAATTATCAATTTTAAAGTAAAATACATAGATCATTCTGTGCCGTGGAGGTATGTAATTGGAGTAGTTAAAGACTGTATTTAGGAATATTGCACC...
TGTAGACCTTGTCTAAGAAACCAAACAAAACACACACATGCACACACTTTACATATATATATAAAATACATATGTATATTTTATATATATCAGAATCCACGATCCCTATAACTATATATATACTATATATATATATATATATATATATTTTTTTTTTTTTTTAATTATAGTATAGTTTTATGGTGGCCAAAAAAGGTTGGCTCTTGTGCCAAGGAAAAATGAGAGCAATTATCAATTTTAAAGTAAAATACATAGATCATTCTGTGCCGTGGAGGTATGTAATTGGAGTAGTTAAAGACTGTATTTAGGAATATTGCACC...
pathogenic
230,137
Clinical classification of chromosome 15, position 40405928, gene IVD (isovaleryl-CoA dehydrogenase): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
TTTATTCCTCATAGTAGCCTTAAAGTTGGTTGGTATCATTTTCGTTTTAAAGATGATGAAACAGTGACTGAAAAGATCTAAGAAACTTGCCGAAAGTCCCACAGCTATGTAGTGGGATTGCATAGACTCCTGGACTCAGGGTACCAACCTGAGATGAGTTGTTCAAGAGCATTGACTTGGCTGGGTTCCGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGACAGGAGGATCACATGAGCCCAGGAGTTCAAGATCAGCTTGGGCAACATAGTGAGACTGCCCACCCCCACCCCGGCCCCATCTCTAATTAA...
TTTATTCCTCATAGTAGCCTTAAAGTTGGTTGGTATCATTTTCGTTTTAAAGATGATGAAACAGTGACTGAAAAGATCTAAGAAACTTGCCGAAAGTCCCACAGCTATGTAGTGGGATTGCATAGACTCCTGGACTCAGGGTACCAACCTGAGATGAGTTGTTCAAGAGCATTGACTTGGCTGGGTTCCGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGACAGGAGGATCACATGAGCCCAGGAGTTCAAGATCAGCTTGGGCAACATAGTGAGACTGCCCACCCCCACCCCGGCCCCATCTCTAATTAA...
pathogenic
230,163
Considering the genetic mutation at chromosome 15, position 40408004, impacting IVD (isovaleryl-CoA dehydrogenase): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
benign
CGAGGAGCAGAGGCAGGTGAGGAGACTGACCCCCTTCCTGGCCCCAAGGCCTCCTTCCTGCCTGGTCCCCAAGGCCTCCTTCCTGCCTGGTCCCCATCGGCCCAGCGCCCACCCAGCCTTGGCTTTTGCCCGTGGGCCGTTGGGAGCGCCAGCGCGGGGGCGGGACGCGGGGCCTCCGACCTCGGGTCCAGTCCTCTGACCTCGGCCTCACGTCTGTGGAGTGAAGATTTGAGACCGTGGGACAGTACTGCTGGAAGTAGAGAGGAGGAGTCGAGGCTGGGAGAGCTCCTGAGAGACTGATGGTGTTTTGGTGGAGGATT...
CGAGGAGCAGAGGCAGGTGAGGAGACTGACCCCCTTCCTGGCCCCAAGGCCTCCTTCCTGCCTGGTCCCCAAGGCCTCCTTCCTGCCTGGTCCCCATCGGCCCAGCGCCCACCCAGCCTTGGCTTTTGCCCGTGGGCCGTTGGGAGCGCCAGCGCGGGGGCGGGACGCGGGGCCTCCGACCTCGGGTCCAGTCCTCTGACCTCGGCCTCACGTCTGTGGAGTGAAGATTTGAGACCGTGGGACAGTACTGCTGGAAGTAGAGAGGAGGAGTCGAGGCTGGGAGAGCTCCTGAGAGACTGATGGTGTTTTGGTGGAGGATT...
benign
230,184
Clinical impact (benign or pathogenic) of the variant at chromosome 15, location 40410721, gene IVD (isovaleryl-CoA dehydrogenase): what disease(s) if pathogenic?
pathogenic; ['Inborn_genetic_diseases', 'Isovaleryl-CoA_dehydrogenase_deficiency']
AGGCGTGGTTGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGCGGTCGTGAGTTCGAGACCAGCCTGACCAACATGGAGAAACTCTGTCTCTACTAAAAATACAAAATTAGCTGGTCATGGTGGTACATCCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACGGAGCGAAACTCCGTTTCAAAAAAAAAAGCCCAGCCTGCTTGGGCCTGTATTCACTCTGGG...
AGGCGTGGTTGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGCGGTCGTGAGTTCGAGACCAGCCTGACCAACATGGAGAAACTCTGTCTCTACTAAAAATACAAAATTAGCTGGTCATGGTGGTACATCCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACGGAGCGAAACTCCGTTTCAAAAAAAAAAGCCCAGCCTGCTTGGGCCTGTATTCACTCTGGG...
pathogenic
230,190
Is the genetic variant on chromosome 15, position 40410737, gene IVD (isovaleryl-CoA dehydrogenase), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
ACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGCGGTCGTGAGTTCGAGACCAGCCTGACCAACATGGAGAAACTCTGTCTCTACTAAAAATACAAAATTAGCTGGTCATGGTGGTACATCCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACGGAGCGAAACTCCGTTTCAAAAAAAAAAGCCCAGCCTGCTTGGGCCTGTATTCACTCTGGGCATGAGAGTATGAGTG...
ACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGCGGTCGTGAGTTCGAGACCAGCCTGACCAACATGGAGAAACTCTGTCTCTACTAAAAATACAAAATTAGCTGGTCATGGTGGTACATCCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTCCAGCCTGGGCAACGGAGCGAAACTCCGTTTCAAAAAAAAAAGCCCAGCCTGCTTGGGCCTGTATTCACTCTGGGCATGAGAGTATGAGTG...
pathogenic
230,191
The mutation in gene IVD (isovaleryl-CoA dehydrogenase) at chromosome 15, position 40411257—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
TTGTATTTTACGGAAGAAAGAGGCAGTTAGAAATCAGATGAAAATGGCCAGGTGTGGTAGTGGGCTCCTATAATCCGAGTGACTCGGGAGGCCAAGGCAGGAGGATCGCTTGAGCCCAGGAGTTCAAGGCTGCAATGAGCCATGGTTACACCATTGCACCCCAGCCTGGATAAGAGAGTGAGAGCCCGCCTCTTGAAAAAAAAAAAGAAAAGAAATCAGATGAAAACTCTTTCAAGGGAACCTGAAAAAGAAAGCTGGTTACAAGTTCTGGTTTCTGCATGATGTCATGGTGGCTGTTTCTAATGTCACCTGCCTTCAGG...
TTGTATTTTACGGAAGAAAGAGGCAGTTAGAAATCAGATGAAAATGGCCAGGTGTGGTAGTGGGCTCCTATAATCCGAGTGACTCGGGAGGCCAAGGCAGGAGGATCGCTTGAGCCCAGGAGTTCAAGGCTGCAATGAGCCATGGTTACACCATTGCACCCCAGCCTGGATAAGAGAGTGAGAGCCCGCCTCTTGAAAAAAAAAAAGAAAAGAAATCAGATGAAAACTCTTTCAAGGGAACCTGAAAAAGAAAGCTGGTTACAAGTTCTGGTTTCTGCATGATGTCATGGTGGCTGTTTCTAATGTCACCTGCCTTCAGG...
pathogenic
230,196
Considering the genetic mutation at chromosome 15, position 40411300, impacting IVD (isovaleryl-CoA dehydrogenase): is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
ATGGCCAGGTGTGGTAGTGGGCTCCTATAATCCGAGTGACTCGGGAGGCCAAGGCAGGAGGATCGCTTGAGCCCAGGAGTTCAAGGCTGCAATGAGCCATGGTTACACCATTGCACCCCAGCCTGGATAAGAGAGTGAGAGCCCGCCTCTTGAAAAAAAAAAAGAAAAGAAATCAGATGAAAACTCTTTCAAGGGAACCTGAAAAAGAAAGCTGGTTACAAGTTCTGGTTTCTGCATGATGTCATGGTGGCTGTTTCTAATGTCACCTGCCTTCAGGCTTTCCTTCCTGCAGTTGTAGGGGCAGGTCAAGGTTTCCTTAG...
ATGGCCAGGTGTGGTAGTGGGCTCCTATAATCCGAGTGACTCGGGAGGCCAAGGCAGGAGGATCGCTTGAGCCCAGGAGTTCAAGGCTGCAATGAGCCATGGTTACACCATTGCACCCCAGCCTGGATAAGAGAGTGAGAGCCCGCCTCTTGAAAAAAAAAAAGAAAAGAAATCAGATGAAAACTCTTTCAAGGGAACCTGAAAAAGAAAGCTGGTTACAAGTTCTGGTTTCTGCATGATGTCATGGTGGCTGTTTCTAATGTCACCTGCCTTCAGGCTTTCCTTCCTGCAGTTGTAGGGGCAGGTCAAGGTTTCCTTAG...
pathogenic
230,200
Chromosome 15, position 40411309, gene IVD (isovaleryl-CoA dehydrogenase): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
TGTGGTAGTGGGCTCCTATAATCCGAGTGACTCGGGAGGCCAAGGCAGGAGGATCGCTTGAGCCCAGGAGTTCAAGGCTGCAATGAGCCATGGTTACACCATTGCACCCCAGCCTGGATAAGAGAGTGAGAGCCCGCCTCTTGAAAAAAAAAAAGAAAAGAAATCAGATGAAAACTCTTTCAAGGGAACCTGAAAAAGAAAGCTGGTTACAAGTTCTGGTTTCTGCATGATGTCATGGTGGCTGTTTCTAATGTCACCTGCCTTCAGGCTTTCCTTCCTGCAGTTGTAGGGGCAGGTCAAGGTTTCCTTAGAGCCTAGAA...
TGTGGTAGTGGGCTCCTATAATCCGAGTGACTCGGGAGGCCAAGGCAGGAGGATCGCTTGAGCCCAGGAGTTCAAGGCTGCAATGAGCCATGGTTACACCATTGCACCCCAGCCTGGATAAGAGAGTGAGAGCCCGCCTCTTGAAAAAAAAAAAGAAAAGAAATCAGATGAAAACTCTTTCAAGGGAACCTGAAAAAGAAAGCTGGTTACAAGTTCTGGTTTCTGCATGATGTCATGGTGGCTGTTTCTAATGTCACCTGCCTTCAGGCTTTCCTTCCTGCAGTTGTAGGGGCAGGTCAAGGTTTCCTTAGAGCCTAGAA...
pathogenic
230,201
For chromosome 15, position 40411600, gene IVD (isovaleryl-CoA dehydrogenase): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
GCAGGTCAAGGTTTCCTTAGAGCCTAGAACGAGCCTGACTTATTGGTCAGAGTGAACATGTGTATAGGACCTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTC...
GCAGGTCAAGGTTTCCTTAGAGCCTAGAACGAGCCTGACTTATTGGTCAGAGTGAACATGTGTATAGGACCTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTC...
pathogenic
230,206
Gene mutation in IVD (isovaleryl-CoA dehydrogenase) at chromosome 15, position 40411620—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
AGCCTAGAACGAGCCTGACTTATTGGTCAGAGTGAACATGTGTATAGGACCTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTCTGTCGCCCAGGCTGGAGTGC...
AGCCTAGAACGAGCCTGACTTATTGGTCAGAGTGAACATGTGTATAGGACCTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTCTGTCGCCCAGGCTGGAGTGC...
pathogenic
230,207
Evaluate the clinical significance of the mutation at chromosome 15, position 40411636 in gene IVD (isovaleryl-CoA dehydrogenase): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
GACTTATTGGTCAGAGTGAACATGTGTATAGGACCTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGG...
GACTTATTGGTCAGAGTGAACATGTGTATAGGACCTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGG...
pathogenic
230,209
Mutation at chromosome 15, position 40411652, within IVD (isovaleryl-CoA dehydrogenase): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
TGAACATGTGTATAGGACCTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCTCTGCAAGCTCCA...
TGAACATGTGTATAGGACCTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCTCTGCAAGCTCCA...
pathogenic
230,210
Chromosome 15, position 40411670, gene IVD (isovaleryl-CoA dehydrogenase): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
CTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCTCTGCAAGCTCCACCTGCCAGGTTCACACCA...
CTTGCTAGGCTTGACCCAATCAGCAGGGCTGGGGGTGGTATCAGGTGTCTCAGCCACTTGGAGTTTGGATCTGCTGCCAAGGAAAAACCGTATATTTTATGAGGAGTTCTGAAATTCTCTGCCAGCATCTCATCTGCCCTCTGCTGTACAGCTCACCTCAAGATTTTCCCTGAGGCTGTGGCTCTCCTGTCCTGTCACCAGTCCTGCTTCTTTCTTTTTTTTTTTTTTTTTTTGAGACAGAATCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCTCTGCAAGCTCCACCTGCCAGGTTCACACCA...
pathogenic
230,211