question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
For chromosome 15, position 40413013, gene IVD (isovaleryl-CoA dehydrogenase): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
ATAATAAAAATAGGACCAGAACTCTTGCATTGAACAACAGACAGACAACATTTGAAGAGAACTCTAAGAAATGGAAGAGTAGGACTAGCTTCCTTTGCAAAGGGAATGGAAAAAGGAGAGGCATTTTCAGCCTTGTAGCCATTGGGCTTAGAAGAGACTTCTAGGACTTTACCGACACCCTGGTCTGAGAGCGAAGTTTGAAGGGGTTTAATGTGGACAGGAAGAGGCAGTACCAGTGAGCTGCTCTAGGGTACTCTGAGGTTGTAACAAGGCCTGTTGGGGGTTTTCCTTGCAGCTGATCAGTGGTGAGTACATCGGAG...
ATAATAAAAATAGGACCAGAACTCTTGCATTGAACAACAGACAGACAACATTTGAAGAGAACTCTAAGAAATGGAAGAGTAGGACTAGCTTCCTTTGCAAAGGGAATGGAAAAAGGAGAGGCATTTTCAGCCTTGTAGCCATTGGGCTTAGAAGAGACTTCTAGGACTTTACCGACACCCTGGTCTGAGAGCGAAGTTTGAAGGGGTTTAATGTGGACAGGAAGAGGCAGTACCAGTGAGCTGCTCTAGGGTACTCTGAGGTTGTAACAAGGCCTGTTGGGGGTTTTCCTTGCAGCTGATCAGTGGTGAGTACATCGGAG...
pathogenic
230,215
Located at chromosome 15 position 40413046, the variant affecting gene IVD (isovaleryl-CoA dehydrogenase)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
ACAACAGACAGACAACATTTGAAGAGAACTCTAAGAAATGGAAGAGTAGGACTAGCTTCCTTTGCAAAGGGAATGGAAAAAGGAGAGGCATTTTCAGCCTTGTAGCCATTGGGCTTAGAAGAGACTTCTAGGACTTTACCGACACCCTGGTCTGAGAGCGAAGTTTGAAGGGGTTTAATGTGGACAGGAAGAGGCAGTACCAGTGAGCTGCTCTAGGGTACTCTGAGGTTGTAACAAGGCCTGTTGGGGGTTTTCCTTGCAGCTGATCAGTGGTGAGTACATCGGAGCCCTGGCCATGAGTGAGCCCAATGCAGGCTCTG...
ACAACAGACAGACAACATTTGAAGAGAACTCTAAGAAATGGAAGAGTAGGACTAGCTTCCTTTGCAAAGGGAATGGAAAAAGGAGAGGCATTTTCAGCCTTGTAGCCATTGGGCTTAGAAGAGACTTCTAGGACTTTACCGACACCCTGGTCTGAGAGCGAAGTTTGAAGGGGTTTAATGTGGACAGGAAGAGGCAGTACCAGTGAGCTGCTCTAGGGTACTCTGAGGTTGTAACAAGGCCTGTTGGGGGTTTTCCTTGCAGCTGATCAGTGGTGAGTACATCGGAGCCCTGGCCATGAGTGAGCCCAATGCAGGCTCTG...
pathogenic
230,217
Variant on chromosome 15, at position 40414968, affecting IVD (isovaleryl-CoA dehydrogenase): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
AGAGGCCTTTCCTTTACCAGGCCCCCTTGGGGCTAATCTGTAACCAGGACCACCTTTTGTTTCCTGTAAAGGGTATGCCTGGCTTTAGCACCTCTAAGAAGCTGGACAAGCTGGGGATGAGGGGCTCTAACACCTGTGAGCTAATCTTTGAAGACTGCAAGATTCCTGGTAAGTAGCACCGGGAATCGGGGAGCCCCTCTCCTGACCCCCTTCCAGGCTGATCTGGCTGTTCTCAAGTTGAGAAAGCCTCTGGGTTAGAGAGGCTTGGCATTGTTAGCGCTTCAGTGACATGTGGCTAGGCTGTGAGCTGGGGCTGCTGG...
AGAGGCCTTTCCTTTACCAGGCCCCCTTGGGGCTAATCTGTAACCAGGACCACCTTTTGTTTCCTGTAAAGGGTATGCCTGGCTTTAGCACCTCTAAGAAGCTGGACAAGCTGGGGATGAGGGGCTCTAACACCTGTGAGCTAATCTTTGAAGACTGCAAGATTCCTGGTAAGTAGCACCGGGAATCGGGGAGCCCCTCTCCTGACCCCCTTCCAGGCTGATCTGGCTGTTCTCAAGTTGAGAAAGCCTCTGGGTTAGAGAGGCTTGGCATTGTTAGCGCTTCAGTGACATGTGGCTAGGCTGTGAGCTGGGGCTGCTGG...
pathogenic
230,222
Clinical significance of chromosome 15, position 40416089, gene IVD (isovaleryl-CoA dehydrogenase): benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
GACAGATGGGGTTTCACCATGTTGGCCAGGCTGCTCTCGAACTCCTGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCCAGGATTATAGGCCTGAGCCACCTTGCCTGGCCAGGGGCATGGATTTGATCAACAGTTAGGTTTGCTGTCTGCCTCAGCCATATACCACGCCTATCACTGACAGCCCAAAAAAGTGTACTTTAATTACAGGGAGCATCCAGGGAGGGGGAGCTGTGCAGCTCCTTCTTTGTTGACAGGAAAAAATTCAGCTAGCATTAAAGGCAGGTCAGTAGTGTCAACCTGTTTTCCTGCCCA...
GACAGATGGGGTTTCACCATGTTGGCCAGGCTGCTCTCGAACTCCTGACCTCAGGTGATCCACCTGTCTCAGCCTCCCAAAGTGCCAGGATTATAGGCCTGAGCCACCTTGCCTGGCCAGGGGCATGGATTTGATCAACAGTTAGGTTTGCTGTCTGCCTCAGCCATATACCACGCCTATCACTGACAGCCCAAAAAAGTGTACTTTAATTACAGGGAGCATCCAGGGAGGGGGAGCTGTGCAGCTCCTTCTTTGTTGACAGGAAAAAATTCAGCTAGCATTAAAGGCAGGTCAGTAGTGTCAACCTGTTTTCCTGCCCA...
pathogenic
230,232
Determine whether the variant at chromosome 15, position 40418167, in gene IVD (isovaleryl-CoA dehydrogenase) is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Isovaleric_acidemia,_type_III', 'Isovaleryl-CoA_dehydrogenase_deficiency']
GGCGTGTCGGCAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAG...
GGCGTGTCGGCAGTATGTCTACAATGTCGCCAAGGCCTGCGATGAGGGCCATTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAG...
pathogenic
230,252
Gene mutation in IVD (isovaleryl-CoA dehydrogenase) at chromosome 15, position 40418218—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Isovaleryl-CoA_dehydrogenase_deficiency']
TTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGG...
TTGCACTGCTAAGGTGAGGGCCAGCCTCAGTCGGGGAGAGGCGGGGGCAGTGGACCAGCTGCTGAGACTTGCTGTCTGCGTGCCTCGCAGGGCCCTGCTGACCCCAGCTTCCTCCCGTAGGACTGTGCAGGTGTGATTCTTTACTCAGCTGAGTGTGCCACACAGGTAGCCCTGGACGGCATTCAGTGTTTTGGTGAGTGATCCCCACTTCCCAGTCCCGGGGCTCCCTCACTCCTGGGGCCTGTGGCTGCTTCAGAAAGCAGTTTCAGGGCGGGCGTGGTGGCTCACACCTATAATCCCAGCACTTTGGGAGGCCGAGG...
pathogenic
230,257
Is the variant located on chromosome 15 at position 40471365, gene CHST14, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Ehlers-Danlos_syndrome,_musculocontractural_type']
AGAAAACTACCCTGTAACACAGAAGGGAGCACATGTGGCCACATTATCAAAAGATTTTTAAAGGTCTAAGGCCTTTTTTTCCTCTCCTGGTTTAAAGGACATACTTACTGGAAAATATGATTTTAATAGAAAATCCTATCACCAGAAATGTATACCTTTAGGATTATTGGAAGCAAGGAGCAGTGTAGACAAGGCAGAACCTTCACGCAAACTTCTGGTGCAGCAAATGGACAGGTGGTAGCCTGCAGATGCACTGGGGCAATCAGATGTGGAGAGCCTGCCCTGGAGAGCTGGAAGGCTGCAAGGCTTTACCGTTCCTT...
AGAAAACTACCCTGTAACACAGAAGGGAGCACATGTGGCCACATTATCAAAAGATTTTTAAAGGTCTAAGGCCTTTTTTTCCTCTCCTGGTTTAAAGGACATACTTACTGGAAAATATGATTTTAATAGAAAATCCTATCACCAGAAATGTATACCTTTAGGATTATTGGAAGCAAGGAGCAGTGTAGACAAGGCAGAACCTTCACGCAAACTTCTGGTGCAGCAAATGGACAGGTGGTAGCCTGCAGATGCACTGGGGCAATCAGATGTGGAGAGCCTGCCCTGGAGAGCTGGAAGGCTGCAAGGCTTTACCGTTCCTT...
pathogenic
230,281
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 15, position 40471383, gene CHST14. What disease(s) is it linked to if pathogenic?
pathogenic; ['Ehlers-Danlos_syndrome,_musculocontractural_type']
ACAGAAGGGAGCACATGTGGCCACATTATCAAAAGATTTTTAAAGGTCTAAGGCCTTTTTTTCCTCTCCTGGTTTAAAGGACATACTTACTGGAAAATATGATTTTAATAGAAAATCCTATCACCAGAAATGTATACCTTTAGGATTATTGGAAGCAAGGAGCAGTGTAGACAAGGCAGAACCTTCACGCAAACTTCTGGTGCAGCAAATGGACAGGTGGTAGCCTGCAGATGCACTGGGGCAATCAGATGTGGAGAGCCTGCCCTGGAGAGCTGGAAGGCTGCAAGGCTTTACCGTTCCTTCCCCTGGCTCATCTGTGT...
ACAGAAGGGAGCACATGTGGCCACATTATCAAAAGATTTTTAAAGGTCTAAGGCCTTTTTTTCCTCTCCTGGTTTAAAGGACATACTTACTGGAAAATATGATTTTAATAGAAAATCCTATCACCAGAAATGTATACCTTTAGGATTATTGGAAGCAAGGAGCAGTGTAGACAAGGCAGAACCTTCACGCAAACTTCTGGTGCAGCAAATGGACAGGTGGTAGCCTGCAGATGCACTGGGGCAATCAGATGTGGAGAGCCTGCCCTGGAGAGCTGGAAGGCTGCAAGGCTTTACCGTTCCTTCCCCTGGCTCATCTGTGT...
pathogenic
230,282
Variant at chromosome position 40471740, chromosome 15, gene CHST14 (carbohydrate sulfotransferase 14): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Ehlers-Danlos_syndrome,_musculocontractural_type']
GCCCTCTAGTATCACCTCATCCCTCAAGTCCCCTCACCCTTCTGAATTCATCTGATCACTGGTAGCTCCATTCTCCCACTGGTATCTTCTATTTTCCATCACCTGCTCTGTACAGTCCGCCCTCGAGTCAGCTGCTTCCTCCCTTCTAGCCATTCCATGATATGCTCCTTTAATCTCTGAAGGGCCGTGATTAGAAATTTAGGTTTTAGACTCAGAACCACCCATACTGAGTCACATCTTCCCTGAGCCTCTGTTACTTCAGCTGTACAAAGGGAATGTCCACACTAGCTCCCTGCCAGGGTGGCTGTAACAACTAAAGG...
GCCCTCTAGTATCACCTCATCCCTCAAGTCCCCTCACCCTTCTGAATTCATCTGATCACTGGTAGCTCCATTCTCCCACTGGTATCTTCTATTTTCCATCACCTGCTCTGTACAGTCCGCCCTCGAGTCAGCTGCTTCCTCCCTTCTAGCCATTCCATGATATGCTCCTTTAATCTCTGAAGGGCCGTGATTAGAAATTTAGGTTTTAGACTCAGAACCACCCATACTGAGTCACATCTTCCCTGAGCCTCTGTTACTTCAGCTGTACAAAGGGAATGTCCACACTAGCTCCCTGCCAGGGTGGCTGTAACAACTAAAGG...
pathogenic
230,291
Variant chromosome 15, position 40615500, gene KNL1 (kinetochore scaffold 1): benign or pathogenic? Disease(s)?
benign
TAAAATTGTTGAAACGAAGAAATGGAAGTAATAGTAGTCATGGTTTAGAAAAGGTACAGAATCAACTCCAACAGAACTTAAAGGAAAAATAATTTTTTAAATAAAAAGGTACAGAAGTATATACATTGAAAAGTAAAAATTATTCCCTCTTTCCCTCTTCTTTCTTTTTTGTGAGACGGGGTTTCGCTCTTGTTGGCCAGACTGGAGTATAATGGCATGATCTTGGCTCACTGCAACCTCAGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTAGGACTACAGGTGTGCACCACTACACCTGGCT...
TAAAATTGTTGAAACGAAGAAATGGAAGTAATAGTAGTCATGGTTTAGAAAAGGTACAGAATCAACTCCAACAGAACTTAAAGGAAAAATAATTTTTTAAATAAAAAGGTACAGAAGTATATACATTGAAAAGTAAAAATTATTCCCTCTTTCCCTCTTCTTTCTTTTTTGTGAGACGGGGTTTCGCTCTTGTTGGCCAGACTGGAGTATAATGGCATGATCTTGGCTCACTGCAACCTCAGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTAGGACTACAGGTGTGCACCACTACACCTGGCT...
benign
230,323
Is the chromosome 15, position 40650517 variant in KNL1 (kinetochore scaffold 1) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
benign
CAAAAACTTGTTCTCTCTTATGATGTTTCTCATCTTTATGTATAGCAGTCACAATTCTTATACATTGTAAAAGCTCAATACTTTCATTGTCTTTGAGGCTCTCTTAACAAGTCCTGTCATCGGCAGCTTCAGCATCTCATGTGTTTATTTTCCTTTCCTATTAAGGCTCACCTTAATTCTGAACTGTGCTATTTCAGTCTTCTAACTAATCTTTATACATTCTTACCATTATTCCACCTTCTTCCATTCCAACCTGCACATTGCTGCCAGATTAATAATTATGAAAGACAGTTTTCATTAATGTTACTCCTCTGAAAAAC...
CAAAAACTTGTTCTCTCTTATGATGTTTCTCATCTTTATGTATAGCAGTCACAATTCTTATACATTGTAAAAGCTCAATACTTTCATTGTCTTTGAGGCTCTCTTAACAAGTCCTGTCATCGGCAGCTTCAGCATCTCATGTGTTTATTTTCCTTTCCTATTAAGGCTCACCTTAATTCTGAACTGTGCTATTTCAGTCTTCTAACTAATCTTTATACATTCTTACCATTATTCCACCTTCTTCCATTCCAACCTGCACATTGCTGCCAGATTAATAATTATGAAAGACAGTTTTCATTAATGTTACTCCTCTGAAAAAC...
benign
230,353
A genetic variant at chromosome 15, position 41815353, affecting gene MAPKBP1 (mitogen-activated protein kinase binding protein 1)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['MAPKBP1-related_disorder', 'Nephronophthisis_20']
TCCCCTGCTTTCCTCTTCCGCTCAGAACATAGACAGCTTCACAGTAAGTGGTGCCTGCACCTTCCTCTCTTTCTCATGCTATTTCTTTCTCTTCACTGGGCTTTTCCTACTGGATCCTCTGGTGCCTAGAAGAATCCTCGGTTCCTAATCCCTGGCTGGACAGGGCTGAGGGGCTCAGAACAGGGCAGCTGGGCGGCTTTTCCCTTGCCCCTGCCTTGGCCGGTCCCTCCTCTTGGCAGGTGGCTGTTGATGGGTGGGGAGGAGAGAAGACTGAGTGGGCAGGTGGCCTTGCTGAGCTGAGCCACTCTGCCCACAGACCA...
TCCCCTGCTTTCCTCTTCCGCTCAGAACATAGACAGCTTCACAGTAAGTGGTGCCTGCACCTTCCTCTCTTTCTCATGCTATTTCTTTCTCTTCACTGGGCTTTTCCTACTGGATCCTCTGGTGCCTAGAAGAATCCTCGGTTCCTAATCCCTGGCTGGACAGGGCTGAGGGGCTCAGAACAGGGCAGCTGGGCGGCTTTTCCCTTGCCCCTGCCTTGGCCGGTCCCTCCTCTTGGCAGGTGGCTGTTGATGGGTGGGGAGGAGAGAAGACTGAGTGGGCAGGTGGCCTTGCTGAGCTGAGCCACTCTGCCCACAGACCA...
pathogenic
230,488
A genetic variant on chromosome 15, position 42359860, affects the gene CAPN3 (calpain 3). Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TGAGACAGAAAGGAAGAAATAACTCACCTAAAGTTACACAGGCACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGG...
TGAGACAGAAAGGAAGAAATAACTCACCTAAAGTTACACAGGCACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGG...
pathogenic
230,562
Chromosome 15, position 42359864, gene CAPN3 (calpain 3): benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
ACAGAAAGGAAGAAATAACTCACCTAAAGTTACACAGGCACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACA...
ACAGAAAGGAAGAAATAACTCACCTAAAGTTACACAGGCACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACA...
pathogenic
230,563
Evaluate if the mutation on chromosome 15 at position 42359903 in CAPN3 (calpain 3) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
ACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCAT...
ACAGCCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCAT...
pathogenic
230,567
Assess the variant on chromosome 15, position 42359907, impacting CAPN3 (calpain 3): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTT...
CCAATAAGGGGCCAACCTAGACTTTGAACCGAGGTGGTCAGTCACCAGAGACCACTGTCCTCTATTCTGCCTCTCCAAGACTAGTAAAAAGCCCTGGGCATTTTCTTGGAGGGACAGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTT...
pathogenic
230,568
Considering the variant on chromosome 15, location 42360022, involving gene CAPN3 (calpain 3), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
AGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCC...
AGATGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCC...
pathogenic
230,572
Evaluate if the mutation on chromosome 15 at position 42360025 in CAPN3 (calpain 3) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTG...
TGGCTAGGCTGATGGTTCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTG...
pathogenic
230,573
Variant on chromosome 15, at position 42360041, affecting CAPN3 (calpain 3): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
TCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACAT...
TCCTGCAAGCCCAGACATAGAGTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACAT...
pathogenic
230,574
Does the variant impacting CAPN3 (calpain 3) on chromosome 15, position 42360062, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTC...
GTCCTTCAAAGCCGCAATCCCAGGGATCAGGAGGCTGATAGTACTCCCTATTTTACCTGTCACTTCCCACCTTCTTCCATAGCCTCTAATCTTGGATTATTGAGACTGGTCGCATGGGAACAGGCATGACTGCAGCCTAGGACATGCCTCCACTCTGCCATACTTGAAATGTGCTCATCTCCTTACAGCCCAGGGAGCAGCTATTGTGGGTAGAAGACAAGGTGGAGGCCAGGCAGGCACTTCCCTTCCCCAGAGCCACTTATGCTCTCATCTAAGAGCCCTGAAACCAGGTGTGACATCCCAGGAGTTGACAGACAGTC...
pathogenic
230,578
Evaluate if the mutation on chromosome 15 at position 42384494 in CAPN3 (calpain 3) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GCAATCTCTGCCTCCCAGGTTCAAGCGATTCTCTCACCTCAGCCTCCCAAGTAGCTGGGACTATAGGCATGCGCCACCATGTCCAACTAATCCTTTTAATCTTTGTAGAGACGGGGTCTCACTATGTTGCCCAGACTGGTCTCGAACTCCTGGCCTCAAATGATCCTCCCACCTTGGCCTCTCAAAGTGCTGGGATTACAGGTGTAGGCCACCACACCTGGACAATATTATTATTTCTTATGGTTCATATTTCTTAGTATCTTCATAACATTCAAGGTTCATATTTCTTTATGGTTTTGGTTTTTGTCCTTAGGATATAT...
GCAATCTCTGCCTCCCAGGTTCAAGCGATTCTCTCACCTCAGCCTCCCAAGTAGCTGGGACTATAGGCATGCGCCACCATGTCCAACTAATCCTTTTAATCTTTGTAGAGACGGGGTCTCACTATGTTGCCCAGACTGGTCTCGAACTCCTGGCCTCAAATGATCCTCCCACCTTGGCCTCTCAAAGTGCTGGGATTACAGGTGTAGGCCACCACACCTGGACAATATTATTATTTCTTATGGTTCATATTTCTTAGTATCTTCATAACATTCAAGGTTCATATTTCTTTATGGTTTTGGTTTTTGTCCTTAGGATATAT...
pathogenic
230,587
Variant on chromosome 15, at position 42384497, affecting CAPN3 (calpain 3): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
ATCTCTGCCTCCCAGGTTCAAGCGATTCTCTCACCTCAGCCTCCCAAGTAGCTGGGACTATAGGCATGCGCCACCATGTCCAACTAATCCTTTTAATCTTTGTAGAGACGGGGTCTCACTATGTTGCCCAGACTGGTCTCGAACTCCTGGCCTCAAATGATCCTCCCACCTTGGCCTCTCAAAGTGCTGGGATTACAGGTGTAGGCCACCACACCTGGACAATATTATTATTTCTTATGGTTCATATTTCTTAGTATCTTCATAACATTCAAGGTTCATATTTCTTTATGGTTTTGGTTTTTGTCCTTAGGATATATTCC...
ATCTCTGCCTCCCAGGTTCAAGCGATTCTCTCACCTCAGCCTCCCAAGTAGCTGGGACTATAGGCATGCGCCACCATGTCCAACTAATCCTTTTAATCTTTGTAGAGACGGGGTCTCACTATGTTGCCCAGACTGGTCTCGAACTCCTGGCCTCAAATGATCCTCCCACCTTGGCCTCTCAAAGTGCTGGGATTACAGGTGTAGGCCACCACACCTGGACAATATTATTATTTCTTATGGTTCATATTTCTTAGTATCTTCATAACATTCAAGGTTCATATTTCTTTATGGTTTTGGTTTTTGTCCTTAGGATATATTCC...
pathogenic
230,588
Assess the variant on chromosome 15, position 42386155, impacting CAPN3: is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GAACTCAATAAATAATAGCTACTGCGGCCGGGCGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCT...
GAACTCAATAAATAATAGCTACTGCGGCCGGGCGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCT...
pathogenic
230,596
Variant in CAPN3, chromosome 15, position 42386165—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
AATAATAGCTACTGCGGCCGGGCGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGT...
AATAATAGCTACTGCGGCCGGGCGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGT...
pathogenic
230,597
Assess the variant on chromosome 15, position 42386187, impacting CAPN3: is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
CGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGTCTATCTACTGTTATTCTTACCT...
CGCGGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGTCTATCTACTGTTATTCTTACCT...
pathogenic
230,598
Considering the variant on chromosome 15, location 42386219, involving gene CAPN3, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGTCTATCTACTGTTATTCTTACCTGGTCATTTCCTTTTTGTTTCACAGGAAATTTG...
TGGGAGGCCGAGGCGGGTGGATCACAAGGTCAAGAGATGGAGACCATCCTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGTCTATCTACTGTTATTCTTACCTGGTCATTTCCTTTTTGTTTCACAGGAAATTTG...
pathogenic
230,599
A genetic variant at chromosome 15, position 42386267, affecting gene CAPN3—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGTCTATCTACTGTTATTCTTACCTGGTCATTTCCTTTTTGTTTCACAGGAAATTTGCGAGAATCCCCGATTTATCATTGATGGAGCCAACAGAACTGACATCTG...
CTGGCCAACATGGTGAAACCGTATCTCTACTAAAGATACAAAAATTAGCTGGGCATGGTGGCGCATGCCTATAGTCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCACTTGAACCCCGGAGGCAGAGGTTTCAGTGAGCCAAGATTGCACCAGTGCACTGCAGCCTGGCGACAGAGTGAGACTCCGTCTCAAAAAAATACCTATCTATCTATCTGTCTATCTACTGTTATTCTTACCTGGTCATTTCCTTTTTGTTTCACAGGAAATTTGCGAGAATCCCCGATTTATCATTGATGGAGCCAACAGAACTGACATCTG...
pathogenic
230,602
A genetic alteration at chromosome 15, position 42387802, in gene CAPN3 (calpain 3)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Absent_Achilles_reflex', 'Absent_muscle_fiber_calpain-3', 'Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'CAPN3-related_disorder', 'Calf_muscle_hypertrophy', 'Cardiac_arrhythmia', 'Congenital_muscular_dystrophy', 'Difficulty_walking', 'E...
AGTCTTCGCTGAAGTCAGAAGAGGAATTGGACTCACATTGCAAAGGCACAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCG...
AGTCTTCGCTGAAGTCAGAAGAGGAATTGGACTCACATTGCAAAGGCACAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCG...
pathogenic
230,612
Assess the variant on chromosome 15, position 42387815, impacting CAPN3 (calpain 3): is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GTCAGAAGAGGAATTGGACTCACATTGCAAAGGCACAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGG...
GTCAGAAGAGGAATTGGACTCACATTGCAAAGGCACAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGG...
pathogenic
230,614
Evaluate the clinical significance of the mutation at chromosome 15, position 42387833 in gene CAPN3 (calpain 3): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CTCACATTGCAAAGGCACAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGGAGTGGCTGGCTGGGATTG...
CTCACATTGCAAAGGCACAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGGAGTGGCTGGCTGGGATTG...
pathogenic
230,615
Clinically, how would you classify the variant at chromosome 15, position 42387850, gene CAPN3 (calpain 3): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'CAPN3-related_disorder', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGGAGTGGCTGGCTGGGATTGGGGCTTTTTCTTCCCAG...
CAGGGCAGGGCAGATTTCCTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGGAGTGGCTGGCTGGGATTGGGGCTTTTTCTTCCCAG...
pathogenic
230,616
Clinically, how would you classify the variant at chromosome 15, position 42387868, gene CAPN3 (calpain 3): benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGGAGTGGCTGGCTGGGATTGGGGCTTTTTCTTCCCAGGAGGAGCAGGAGTGCTCA...
CTACAGGTGTTAGGAAGAACAACCCAGTTATGATCACCTACTGCTCTGTCTCCATTGAGGCCTAAAAAGGAAGTGAGTTTATACTGCAGTTGGAGGAACTGCCTGCAGCCTTGAGGAAAATGTCTAGTCACAAGGGAGTAAGTTACCTGTTGATCATATTGTCAAGGAATTCCTGTCCAATTCTCCTTCCCTGGGTTGACACCTCTGTAAGGTCAGATCTGGAAGTAGGAGAGTGGGCACCAAGGGAGTCCCCGTTCAGGGAAGTGGAGTGGCTGGCTGGGATTGGGGCTTTTTCTTCCCAGGAGGAGCAGGAGTGCTCA...
pathogenic
230,618
Is chromosome 15, position 42388934, gene CAPN3 (calpain 3) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GTGAGGGTCTCGTAGCTTCCGGGATGCTGGGGAGTCAGCCTGTCTCCAGCTTCAAAGGCTCCCTCATGTCCCAGGATGACCCACATTATCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAAC...
GTGAGGGTCTCGTAGCTTCCGGGATGCTGGGGAGTCAGCCTGTCTCCAGCTTCAAAGGCTCCCTCATGTCCCAGGATGACCCACATTATCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAAC...
pathogenic
230,623
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 15, position 42389006, gene CAPN3 (calpain 3). What disease(s) is it linked to if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
AGGATGACCCACATTATCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGA...
AGGATGACCCACATTATCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGA...
pathogenic
230,631
Evaluate if the mutation on chromosome 15 at position 42389006 in CAPN3 (calpain 3) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Abnormality_of_the_musculature', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
AGGATGACCCACATTATCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGA...
AGGATGACCCACATTATCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGA...
pathogenic
230,632
Variant at chromosome 15, position 42389022, gene CAPN3 (calpain 3): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGT...
TCAGTTCTTGCTCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGT...
pathogenic
230,633
Considering the variant on chromosome 15, location 42389033, involving gene CAPN3 (calpain 3), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
TCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTC...
TCCCCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTC...
pathogenic
230,634
Variant in gene CAPN3 (calpain 3), located at chromosome 15 position 42389036: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
CCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAAT...
CCGGGTCTTGCACCTCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAAT...
pathogenic
230,635
The chromosome 15, position 42389050 genetic variant in gene CAPN3 (calpain 3): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGT...
TCAGCACGGAAGGCCTCAGAAAAGGTCTGTCTCCAGGCTCAGACTCCCCCTCCTGCCGCCTTGGGAACATGGCATATTTAAAGGGTCTCAGATCTAAAGGGCCTTACATACAAATATCAGATAGATTTCTGTTCTCATTTCAATGAGGGAGAAAGTGCCATTGAAAAGGAGACTAAACCACATTTGGCCCTTTTCAGTTCAAACTGATTCATTCAAAAAAGAGCGACATCCAAACTTGAAATGATTGAACAATGTTCCTGCTACAGCTAGAATAGATTCTGGGTCACTTTGTTCCTCCGTTTCAATCCTTGTTCTTCAGT...
pathogenic
230,638
Considering the variant on chromosome 15, location 42389999, involving gene CAPN3 (calpain 3), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCT...
GAGACCTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCT...
pathogenic
230,645
Variant at chromosome 15, position 42390004, gene CAPN3 (calpain 3): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
CTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACT...
CTCACTCACAGGAAGAGGCATGTGCCTCTATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACT...
pathogenic
230,646
Evaluate the clinical significance of the mutation at chromosome 15, position 42390033 in gene CAPN3 (calpain 3): benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
ATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATG...
ATACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATG...
pathogenic
230,648
Regarding the variant at chromosome 15 and position 42390034, affecting gene CAPN3 (calpain 3): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGG...
TACGTGCATATGTGTGGGCATGCAAGTCCAACTGTGACCCAAAGTTAGAGATCAGTTCCAGGCAACAACAGCTCTAACTAAAAACATTAAATTTAAGAGTAGAAATGAAGATTTGCATAGAAGACCTTTAGCTTTAGCTTACCATAGCGAGTTCTTTCATTGCACCTCCATGGTGGCATTGCAAGTCTTGGATCAGAGCATTGTATCTCTGGAGCTCAGATCCCAGGGTCTCGCTTGGCTCAACCTCATGTGCTTATAGCAGATTTATAAAGCCATGTTGTCTCTCAACTTAAAAGCTCCACCCCAGATGCTAATAATGG...
pathogenic
230,649
Is the genetic change at chromosome 15, position 42392634, within gene CAPN3 (calpain 3) benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
TACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCC...
TACTGAGCCATACAGAAAAACACAGAGGAAAATTTCACTTATATTTTTCCCCATGTAAAGATAACCACTCTTAACATCTAGTATATGTTCTTCCAGGATTTTTCTATGCACACACTGAATCTGTATTTTTATTTTTAAAATGTTATCATATTGTATGTACCTCTTTGCAGCCTGCTTTTTTCAGTTAGTTTTTTTTGTTTTTTTGTTTTTTTTTTTTTTTTTGGAAACCAAGTCTTGCTCTATTCCCTAGGCTGGAGCACAGTGGTGCCATCTCGGCTCACTGCAACCTCTGCCTCCAAAGTTAAACTAATTCTCCTGCC...
pathogenic
230,655
A mutation at chromosome position 42394267 on chromosome 15 in gene CAPN3 (calpain 3): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
ACCCCTTTTCTCAACCTCTTTCTCTTCCAGGAATAGTCAACCCTGGATGGCTTCAGGGGAAGGGGGATCCTGAAGCCCAGGGCAGCCTCCAACTCTACCCCTTCCTCCTTTGAAGGATACTAAGGGGTCCAGAAAGGAGGGGCAGGACACTGTTACCCACCCCACATCCCAGCATCCACATTGCTCTCTGATGGTCAGGACAGAGCCTTCTCAGGGAGACCAGCCTGTCTGGAGCTGTGTCTCTTGGCACTCTTAAAGGGCCACTGAAGGTCCGTTCGTGGTCGTGAGGCACACTTTCAGGGAGCAGAGTGGTCTGTGTC...
ACCCCTTTTCTCAACCTCTTTCTCTTCCAGGAATAGTCAACCCTGGATGGCTTCAGGGGAAGGGGGATCCTGAAGCCCAGGGCAGCCTCCAACTCTACCCCTTCCTCCTTTGAAGGATACTAAGGGGTCCAGAAAGGAGGGGCAGGACACTGTTACCCACCCCACATCCCAGCATCCACATTGCTCTCTGATGGTCAGGACAGAGCCTTCTCAGGGAGACCAGCCTGTCTGGAGCTGTGTCTCTTGGCACTCTTAAAGGGCCACTGAAGGTCCGTTCGTGGTCGTGAGGCACACTTTCAGGGAGCAGAGTGGTCTGTGTC...
pathogenic
230,666
Chromosome 15, position 42399593, gene CAPN3 (calpain 3): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTACAGTGAGCCCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAA...
GAGGCAGGAGAATCACTTGAACCTGGGAGGCAGAGGTTACAGTGAGCCCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAA...
pathogenic
230,685
Considering the variant on chromosome 15, location 42399616, involving gene CAPN3 (calpain 3), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'CAPN3-related_disorder', 'Cardiac_arrhythmia', 'Elbow_flexion_contracture', 'Lower-limb_joint_contracture', 'Muscle_weakness', 'Muscular_dystrophy', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TGGGAGGCAGAGGTTACAGTGAGCCCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGT...
TGGGAGGCAGAGGTTACAGTGAGCCCAGATTGCGCCACTGCACTCCAGCCTGGGCGACAAGAGAGACTCTGTCTTGGAAAAAAAAAAAAAAATGTTGTCTTAGTATAATGTCAAGGGAAAGGTTTTTTGTGTTTTTATTACTTTATTTTTTATTTAAAAACTATAATAGAGACGGGCCTCGCTATATTTCTCGGGCTGGTCTCAAACTCCTGGGCTCAAGCGGTCCTCCCACCTTGGCCTCCCAAAATGCTGGCATGTGGGCCTGGTCAACATATGGGACCCCAACTCTACAAAAAATTTTAAAATTAGCCAGATGTGGT...
pathogenic
230,691
A mutation at chromosome position 42401642 on chromosome 15 in gene CAPN3: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
TGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTT...
TGTGAACGAGGGCCGCTGGGTACGGGGTTGCTCTGCCGGAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTT...
pathogenic
230,702
Considering the genetic mutation at chromosome 15, position 42401680, impacting CAPN3: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCT...
GAGGCTGCCGCAACTTCCCAGGTGGGAGATGCTCTTGATGGGGGGAGGGTCTAAGCCGAAAAAGTTCCAGGCAGAAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCT...
pathogenic
230,704
Mutation found at chromosome 15 position 42401754, gene CAPN3 (calpain 3): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
AAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGG...
AAGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGG...
pathogenic
230,712
Variant in gene CAPN3 (calpain 3), located at chromosome 15 position 42401755: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
AGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGG...
AGAAGCCTAACTAGTGCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGG...
pathogenic
230,714
Benign or pathogenic: chromosome 15, position 42401770, gene CAPN3 (calpain 3) variant? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACT...
GCTTATTAAGTCTCTCTGTTCCAGACGTCCACTATCTTATTAAACCTTCCCTGTTTTACTGAGAAGGAAACCACCATGCTGAGAAGTTTGCAATAGGGAGCTGGTAGCAACTTTGAAGCAGGAAACTGTGGGAACAATGCAGATGCTGCTTGACTTACGATGAGGTTATGTCCAGATAAGCCCATCCATCTTTGAAAATACCCTAAGTGAAAAGTGCATTCAATATGCCTAACCCACCAAACATCATAGCTTAGCCTGGCCTACCTTAAACATGCTCGGAACACTGACCTTAGCCTAAAGTTGGGCAAAATCATCTAACT...
pathogenic
230,716
Is chromosome 15, position 42402088, gene CAPN3 (calpain 3) variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
benign
CTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGA...
CTCAAAGCCTATTTTACAAGAAAGTGTTGAATATCTCATGTAACTTACTTAATACTGTACTAAAAGTGAAAAACAGAATGGTTGTACGGGTACTCGAAATCCAGTTTCTACTGAATGTGCATCTCTTTCACATTGTAAAGTTAAAAAATTGTAGCCGAACCATCCTAAGTCAGGGACTGTGAGTACTGTGTCAGTAACAGTAAGGGCACTATTGGAGAACCAAGTTAGCAGCTGCTGCAATAGTTCAAGTCAGAGATGATGAAAACCTAGACCAAGTCAGTAGCAGCAGAGATGGAGGGGAGACAGCAGATTTAGGGAGA...
benign
230,720
Does the variant on chromosome 15 at location 42402897 affecting gene CAPN3 (calpain 3) have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCT...
TTAGATGGCACTTGGTGATATGATAAGAACTCAAAAAATATTTGAGGAATAAAGGAAAGAAGAGGCCAGACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCT...
pathogenic
230,728
Considering the variant on chromosome 15, location 42402966, involving gene CAPN3 (calpain 3), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
ACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTC...
ACGTGGTGGCTTATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTC...
pathogenic
230,734
Is the variant located on chromosome 15 at position 42402978, gene CAPN3 (calpain 3), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
ATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCG...
ATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCG...
pathogenic
230,737
Does the variant impacting CAPN3 (calpain 3) on chromosome 15, position 42402999, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
TGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAA...
TGGGAGGCTGAGGCAGGCGGATCACTTGTGGTCAGGAGTTCGAGACCAGCTTGGCTAACATGGTGAAAACCCATCTCTACTAAAGATACAAAAATTAACCGGGGATGATGGTGGGTGCCTGTAATCCCAGCTACTTGGGAGGCTCAGTCAGAAGAATCGCTTGAACCCAGGAGGCGGAGGCTGCAGTGAGCCGAGATCGCGCCACTGCACTCTAGCCTGGGCAACAGAGCCAGACTCCGTCTCAAAAAAAAAAAAGTGAGAGAGATTGAGGCTGGGATATATGGCTCAGGCATCATGCGCGTGTAGGGGGCAGTTAAAAA...
pathogenic
230,738
Clinical classification of chromosome 15, position 42403764, gene CAPN3 (calpain 3): benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGC...
TTTGCAGCTTCCTGGTGGCCCTGATGCAGAAGAACCGGCGGAAGGACCGGAAGCTAGGGGCCAGTCTCTTCACCATTGGCTTCGCCATCTACGAGGTGTGCAGTCCTGATTGGCTCCAGCCCAGGAAACATACTTTCCCAGGGAGGACGCTTCCAGGGGCTTCTAGAGGGGCCCTCTGGCTTCCTCAATACCCAGTGACCCACAGAGCTCCTGGTATCAGGACCACTTGTGTTTGTAACAAGCAAAAAATACCAGGGGGGGCATTAGAGAGGCAGTGGAGCGGGCCTGGCAGAACAGGTGCCTGGGGGTCAGGCTTCCGC...
pathogenic
230,741
Variant on chromosome 15, at position 42405919, affecting CAPN3 (calpain 3): is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGG...
CAGAGGGAATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGG...
pathogenic
230,748
Is the variant located on chromosome 15 at position 42405927, gene CAPN3 (calpain 3), benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
ATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCT...
ATGGGAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCT...
pathogenic
230,749
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 15, position 42405931, gene CAPN3 (calpain 3). What disease(s) is it linked to if pathogenic?
pathogenic; ['Abnormality_of_the_musculature', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGAC...
GAGTCTGGGCTGTGCTGAGCAGTCCCTCCTTGGCACTGCAAATCCTACTTTGGCATGGCCAGAAGTAATCGGCCTTAAGCACCGGGGGCCATTGAGGCAGTTCAGGGGCTGGGAAATATGGAAGAGGGTCCTGGAAAGGAGAAGCAATTTGAACAATCGGAGGGAACAAGGCCACAGGAAGGGATGACAAGAGCCGCAGCGAACACTGGATTCTGAGACTGGATAACATTGGATTTCACACATAGAGAAAAGAAAGTAAGCTGGTGCCGGACCTGGTGTTGACACTTGGATCCTCCACTTACCAGCGGGGTGACCTGGAC...
pathogenic
230,750
Does the genetic variant at chromosome 15, position 42408246, impacting gene CAPN3 (calpain 3), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TAGTACTATAACTATCCCCATTTTCAGAGGGAGAAAAGGTACAGACTTGACTAACTTGCCCAAGGCCACACAGCCAGAGAGGGGCAGAGCCAGTACTTAGAGCCAGGCAGTCTGGGTCCAGAGTCCGTGTCCTGAACCACAAGAGGCCATCATACACCATCAGATTTGGTGCTAGCATTTCTGGTGGTGCCTGGTGGTGATGGATCCATCACAGGGGTCCTCCAGGTACTGGTGCTGGCCCAGACCAGAGCTGACACTCCTCAGGCACTACCACATTCCAGGCACTGTGCTTGGGGTCAGTCCCTCTCTTTTTTTTCCCC...
TAGTACTATAACTATCCCCATTTTCAGAGGGAGAAAAGGTACAGACTTGACTAACTTGCCCAAGGCCACACAGCCAGAGAGGGGCAGAGCCAGTACTTAGAGCCAGGCAGTCTGGGTCCAGAGTCCGTGTCCTGAACCACAAGAGGCCATCATACACCATCAGATTTGGTGCTAGCATTTCTGGTGGTGCCTGGTGGTGATGGATCCATCACAGGGGTCCTCCAGGTACTGGTGCTGGCCCAGACCAGAGCTGACACTCCTCAGGCACTACCACATTCCAGGCACTGTGCTTGGGGTCAGTCCCTCTCTTTTTTTTCCCC...
pathogenic
230,756
The genetic variant at chromosome 15, position 42408272, affecting gene CAPN3 (calpain 3): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GAGGGAGAAAAGGTACAGACTTGACTAACTTGCCCAAGGCCACACAGCCAGAGAGGGGCAGAGCCAGTACTTAGAGCCAGGCAGTCTGGGTCCAGAGTCCGTGTCCTGAACCACAAGAGGCCATCATACACCATCAGATTTGGTGCTAGCATTTCTGGTGGTGCCTGGTGGTGATGGATCCATCACAGGGGTCCTCCAGGTACTGGTGCTGGCCCAGACCAGAGCTGACACTCCTCAGGCACTACCACATTCCAGGCACTGTGCTTGGGGTCAGTCCCTCTCTTTTTTTTCCCCCCCAATTATAACAGTATCTACAAAGT...
GAGGGAGAAAAGGTACAGACTTGACTAACTTGCCCAAGGCCACACAGCCAGAGAGGGGCAGAGCCAGTACTTAGAGCCAGGCAGTCTGGGTCCAGAGTCCGTGTCCTGAACCACAAGAGGCCATCATACACCATCAGATTTGGTGCTAGCATTTCTGGTGGTGCCTGGTGGTGATGGATCCATCACAGGGGTCCTCCAGGTACTGGTGCTGGCCCAGACCAGAGCTGACACTCCTCAGGCACTACCACATTCCAGGCACTGTGCTTGGGGTCAGTCCCTCTCTTTTTTTTCCCCCCCAATTATAACAGTATCTACAAAGT...
pathogenic
230,758
A genetic alteration at chromosome 15, position 42409349, in gene CAPN3 (calpain 3)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
TAAAGGATGAGTAAACTGAGGCCAGAGAGGATATTTTTGGTTTTTTTTGAGACAGTCTCACTCTGTCACCCAGCCTGGAGTGCAGTGGCTTGATCTTGGCTCACTGCAAGCTCCACCTCCCATGTTCACACCATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCACCACCACACCCAGCTAATTTTTTTGTATCTTTAGTAGAGATGGGGTTTCACCCAGTTAGCCAGGATGGTCTTGATCTCCTGACCTTGTGATCTGCCTGCTTCGGCCTCCTAAAGTGCTGGGATTACAGGCGTGAGCCACCGT...
TAAAGGATGAGTAAACTGAGGCCAGAGAGGATATTTTTGGTTTTTTTTGAGACAGTCTCACTCTGTCACCCAGCCTGGAGTGCAGTGGCTTGATCTTGGCTCACTGCAAGCTCCACCTCCCATGTTCACACCATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCACCACCACACCCAGCTAATTTTTTTGTATCTTTAGTAGAGATGGGGTTTCACCCAGTTAGCCAGGATGGTCTTGATCTCCTGACCTTGTGATCTGCCTGCTTCGGCCTCCTAAAGTGCTGGGATTACAGGCGTGAGCCACCGT...
pathogenic
230,769
Is the genetic mutation found on chromosome 15 at position 42409368, within the gene CAPN3 (calpain 3), considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GGCCAGAGAGGATATTTTTGGTTTTTTTTGAGACAGTCTCACTCTGTCACCCAGCCTGGAGTGCAGTGGCTTGATCTTGGCTCACTGCAAGCTCCACCTCCCATGTTCACACCATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCACCACCACACCCAGCTAATTTTTTTGTATCTTTAGTAGAGATGGGGTTTCACCCAGTTAGCCAGGATGGTCTTGATCTCCTGACCTTGTGATCTGCCTGCTTCGGCCTCCTAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCAGAGAGGATAT...
GGCCAGAGAGGATATTTTTGGTTTTTTTTGAGACAGTCTCACTCTGTCACCCAGCCTGGAGTGCAGTGGCTTGATCTTGGCTCACTGCAAGCTCCACCTCCCATGTTCACACCATTTTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTACAGGCACCCACCACCACACCCAGCTAATTTTTTTGTATCTTTAGTAGAGATGGGGTTTCACCCAGTTAGCCAGGATGGTCTTGATCTCCTGACCTTGTGATCTGCCTGCTTCGGCCTCCTAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCGGCCAGAGAGGATAT...
pathogenic
230,770
Is the genetic variant on chromosome 15, position 42409791, gene CAPN3 (calpain 3), benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GGTTGTAGAGGTTCCTTTGAGGTGCCTCAGTAGCTGCCATGGTGATGTGGGGTGCTGAGGGCAAAGAGCTCTGTTCTCATTAATCAGAGAAGCTTGTGTTTTTATATACACCATGTTTCTGCAGGAAATTTAATTTGAACAGTGTTTCCATCTGGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGA...
GGTTGTAGAGGTTCCTTTGAGGTGCCTCAGTAGCTGCCATGGTGATGTGGGGTGCTGAGGGCAAAGAGCTCTGTTCTCATTAATCAGAGAAGCTTGTGTTTTTATATACACCATGTTTCTGCAGGAAATTTAATTTGAACAGTGTTTCCATCTGGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGA...
pathogenic
230,774
Variant at chromosome position 42409825, chromosome 15, gene CAPN3 (calpain 3): benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
TGCCATGGTGATGTGGGGTGCTGAGGGCAAAGAGCTCTGTTCTCATTAATCAGAGAAGCTTGTGTTTTTATATACACCATGTTTCTGCAGGAAATTTAATTTGAACAGTGTTTCCATCTGGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGC...
TGCCATGGTGATGTGGGGTGCTGAGGGCAAAGAGCTCTGTTCTCATTAATCAGAGAAGCTTGTGTTTTTATATACACCATGTTTCTGCAGGAAATTTAATTTGAACAGTGTTTCCATCTGGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGC...
pathogenic
230,775
Variant at chromosome 15, position 42409826, gene CAPN3 (calpain 3): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GCCATGGTGATGTGGGGTGCTGAGGGCAAAGAGCTCTGTTCTCATTAATCAGAGAAGCTTGTGTTTTTATATACACCATGTTTCTGCAGGAAATTTAATTTGAACAGTGTTTCCATCTGGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGCC...
GCCATGGTGATGTGGGGTGCTGAGGGCAAAGAGCTCTGTTCTCATTAATCAGAGAAGCTTGTGTTTTTATATACACCATGTTTCTGCAGGAAATTTAATTTGAACAGTGTTTCCATCTGGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGCC...
pathogenic
230,776
For chromosome 15, position 42409844, gene CAPN3 (calpain 3): benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GCTGAGGGCAAAGAGCTCTGTTCTCATTAATCAGAGAAGCTTGTGTTTTTATATACACCATGTTTCTGCAGGAAATTTAATTTGAACAGTGTTTCCATCTGGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGCCTATTCCTTTCCTCTTCTC...
GCTGAGGGCAAAGAGCTCTGTTCTCATTAATCAGAGAAGCTTGTGTTTTTATATACACCATGTTTCTGCAGGAAATTTAATTTGAACAGTGTTTCCATCTGGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGCCTATTCCTTTCCTCTTCTC...
pathogenic
230,777
Variant at chromosome 15, position 42409944, gene CAPN3 (calpain 3): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGCCTATTCCTTTCCTCTTCTCACTGGATAAAGCTGCTCCAAGAGAGGTGCTGCCTCAGTGTGCCTGTTCAGACTGTAATCCTCCCTTCCTTCCTGCCTCCTCCCTCCTCTCTCCAGCCCAT...
GGAAAAAAAAAAGTCTACAAAATACTTGACAATCACTGCACTAGATCATGCTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGCCTATTCCTTTCCTCTTCTCACTGGATAAAGCTGCTCCAAGAGAGGTGCTGCCTCAGTGTGCCTGTTCAGACTGTAATCCTCCCTTCCTTCCTGCCTCCTCCCTCCTCTCTCCAGCCCAT...
pathogenic
230,782
Mutation at chromosome 15, position 42409994, within CAPN3 (calpain 3): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGCCTATTCCTTTCCTCTTCTCACTGGATAAAGCTGCTCCAAGAGAGGTGCTGCCTCAGTGTGCCTGTTCAGACTGTAATCCTCCCTTCCTTCCTGCCTCCTCCCTCCTCTCTCCAGCCCATCATCTTCGTTTCGGACAGAGCAAACAGCAACAAGGAGCTGGGTGTGGACC...
CTGCTTTTAGCATTCTTAGCATTTCACGTGCTGAGCTCTCAATACTCTACCATGAGGAGGGATGGAGTGGGTATGAAAAGATAAAGAACTGAAGTCACACGGCTTGTCAGTGGCAGAGATAGAGCTTGAACCGAGGTTGAAGAGCTCCCGCCTATTCCTTTCCTCTTCTCACTGGATAAAGCTGCTCCAAGAGAGGTGCTGCCTCAGTGTGCCTGTTCAGACTGTAATCCTCCCTTCCTTCCTGCCTCCTCCCTCCTCTCTCCAGCCCATCATCTTCGTTTCGGACAGAGCAAACAGCAACAAGGAGCTGGGTGTGGACC...
pathogenic
230,785
Does the genetic variant at chromosome 15, position 42410490, impacting gene CAPN3 (calpain 3), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GAATTTGTCCCACTGACCTTTTCTTTCAGCAAGTTCCCCTGAAATTTGGGCTGCTGCTTGGGTGAATATCCCAGGATGGGGGTTCCATTCTAGGAGTGGACTGGCAGGCTGAGCCTCCCATGGAGCTGATCCAGCCAGGATACAGAGAAGGGGAGGCAAAGGCTGAGACAGAACCAGCTTGAGAGCGGAGGCGCAACTCTTGTCTCCTGGTGGCCTTGAGCATTTCACAATAGGGGGATAAAGGATAGGAGCAGAAAAGTGGGGCTGACTTCAGAAATGGGGTCCTCTAGAGCTCACGGGAGGGTGTTAGATTGGAGTGG...
GAATTTGTCCCACTGACCTTTTCTTTCAGCAAGTTCCCCTGAAATTTGGGCTGCTGCTTGGGTGAATATCCCAGGATGGGGGTTCCATTCTAGGAGTGGACTGGCAGGCTGAGCCTCCCATGGAGCTGATCCAGCCAGGATACAGAGAAGGGGAGGCAAAGGCTGAGACAGAACCAGCTTGAGAGCGGAGGCGCAACTCTTGTCTCCTGGTGGCCTTGAGCATTTCACAATAGGGGGATAAAGGATAGGAGCAGAAAAGTGGGGCTGACTTCAGAAATGGGGTCCTCTAGAGCTCACGGGAGGGTGTTAGATTGGAGTGG...
pathogenic
230,793
A mutation at chromosome position 42410606 on chromosome 15 in gene CAPN3 (calpain 3): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CCCATGGAGCTGATCCAGCCAGGATACAGAGAAGGGGAGGCAAAGGCTGAGACAGAACCAGCTTGAGAGCGGAGGCGCAACTCTTGTCTCCTGGTGGCCTTGAGCATTTCACAATAGGGGGATAAAGGATAGGAGCAGAAAAGTGGGGCTGACTTCAGAAATGGGGTCCTCTAGAGCTCACGGGAGGGTGTTAGATTGGAGTGGGAGCTTAGTGGAGGTGAGCCTTAGAGGCAAAAGTCTCCAGACCAATCCAGGGCCCCTCTTCTATCCGGGGGCCCCTCTTCTATCCAGGGCCCCTCTTCTGTCTGGGAGCCCCTCTT...
CCCATGGAGCTGATCCAGCCAGGATACAGAGAAGGGGAGGCAAAGGCTGAGACAGAACCAGCTTGAGAGCGGAGGCGCAACTCTTGTCTCCTGGTGGCCTTGAGCATTTCACAATAGGGGGATAAAGGATAGGAGCAGAAAAGTGGGGCTGACTTCAGAAATGGGGTCCTCTAGAGCTCACGGGAGGGTGTTAGATTGGAGTGGGAGCTTAGTGGAGGTGAGCCTTAGAGGCAAAAGTCTCCAGACCAATCCAGGGCCCCTCTTCTATCCGGGGGCCCCTCTTCTATCCAGGGCCCCTCTTCTGTCTGGGAGCCCCTCTT...
pathogenic
230,796
A genetic alteration at chromosome 15, position 42410632, in gene CAPN3 (calpain 3)—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
CAGAGAAGGGGAGGCAAAGGCTGAGACAGAACCAGCTTGAGAGCGGAGGCGCAACTCTTGTCTCCTGGTGGCCTTGAGCATTTCACAATAGGGGGATAAAGGATAGGAGCAGAAAAGTGGGGCTGACTTCAGAAATGGGGTCCTCTAGAGCTCACGGGAGGGTGTTAGATTGGAGTGGGAGCTTAGTGGAGGTGAGCCTTAGAGGCAAAAGTCTCCAGACCAATCCAGGGCCCCTCTTCTATCCGGGGGCCCCTCTTCTATCCAGGGCCCCTCTTCTGTCTGGGAGCCCCTCTTCTATCTGGGGCCTCATGCAGTGGGGC...
CAGAGAAGGGGAGGCAAAGGCTGAGACAGAACCAGCTTGAGAGCGGAGGCGCAACTCTTGTCTCCTGGTGGCCTTGAGCATTTCACAATAGGGGGATAAAGGATAGGAGCAGAAAAGTGGGGCTGACTTCAGAAATGGGGTCCTCTAGAGCTCACGGGAGGGTGTTAGATTGGAGTGGGAGCTTAGTGGAGGTGAGCCTTAGAGGCAAAAGTCTCCAGACCAATCCAGGGCCCCTCTTCTATCCGGGGGCCCCTCTTCTATCCAGGGCCCCTCTTCTGTCTGGGAGCCCCTCTTCTATCTGGGGCCTCATGCAGTGGGGC...
pathogenic
230,798
Does the genetic variant at chromosome 15, position 42410897, impacting gene CAPN3 (calpain 3), appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'CAPN3-related_disorder', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
GGCCCCTCTTCTGTCTGGGAGCCCCTCTTCTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGC...
GGCCCCTCTTCTGTCTGGGAGCCCCTCTTCTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGC...
pathogenic
230,806
Evaluate if the mutation on chromosome 15 at position 42410909 in CAPN3 (calpain 3) is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GTCTGGGAGCCCCTCTTCTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCC...
GTCTGGGAGCCCCTCTTCTATCTGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCC...
pathogenic
230,808
Gene CAPN3 (calpain 3) variant at chromosome position 42410931 on chromosome 15: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
TGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCG...
TGGGGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCG...
pathogenic
230,811
Mutation at chromosome 15, position 42410934, within CAPN3 (calpain 3): benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCC...
GGCCTCATGCAGTGGGGCCTAGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCC...
pathogenic
230,812
Is the chromosome 15, position 42410954 variant in CAPN3 (calpain 3) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4']
AGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCC...
AGGGGAGGTTCTCTGAGGACTTGGCCTTGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCC...
pathogenic
230,815
The genetic variant at chromosome 15, position 42410981, affecting gene CAPN3 (calpain 3): benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
TGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGG...
TGATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGG...
pathogenic
230,817
Variant at chromosome 15, position 42410982, gene CAPN3 (calpain 3): clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A']
GATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGC...
GATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGC...
pathogenic
230,818
Considering the variant on chromosome 15, location 42410982, involving gene CAPN3 (calpain 3), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy', 'Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2A', 'Muscular_dystrophy,_limb-girdle,_autosomal_dominant_4', 'Myositis,_eosinophilic']
GATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGC...
GATGACAGGGTGGCTGGAGGAATCAGAACGGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGC...
pathogenic
230,819
Is the genetic change at chromosome 15, position 42411011, within gene CAPN3 (calpain 3) benign or pathogenic? Name the disease(s) if pathogenic.
benign
GGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGT...
GGTCAGACCTTCTTTGACCTGCGGGCACCTTTAGTTGGAATGGTCAGGCCTGGGATGGTGGAGGGGGCTCTTGCAGGTGGGGACTGGGGTGGCGGGGAGGAGGCTGTATGGCCGCCATATCTCCTTTGGCTGGGGGCGTCAGGGCTGGAGAGGTGTGAAGAGTCCCTGAGGCCTCGATGCATCTCACTCCAGCTCACCAGGTCTGCATTTGCCCGTCCCCAGCTCCTGCTGCCACCTCCGGCCGTTTTAGGCACTTGGCTCCCTTGGCCCAGAGGAGCTTGCCTCACAGGCCTGTGCACCTCTGACCCCTGTGAACCAGT...
benign
230,822
Regarding the variant at chromosome 15 and position 42727692, affecting gene CDAN1 (codanin 1): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic
GCCCTAGGATAGGAATTTGATCTGCAACTGTGGAAAGAGGAAAGCCAAGCTTTAAAAGATGGGGGCAGGCCGGGTGCGGTGACTCACACCTATAATCCCAACACTTCGGGAGGCTGAGGTGGGCAGATCAGGGGTTCGAGACCAGTCTGGCCAACATAGTGAAACCCCATCTCTATTAAAAATACCAAAATTAGCCAGGCGTGGTGGAAGGCACCTGTAGTCCCAGCTACTTGGCCGAGGCAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTTAGCTAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAACA...
GCCCTAGGATAGGAATTTGATCTGCAACTGTGGAAAGAGGAAAGCCAAGCTTTAAAAGATGGGGGCAGGCCGGGTGCGGTGACTCACACCTATAATCCCAACACTTCGGGAGGCTGAGGTGGGCAGATCAGGGGTTCGAGACCAGTCTGGCCAACATAGTGAAACCCCATCTCTATTAAAAATACCAAAATTAGCCAGGCGTGGTGGAAGGCACCTGTAGTCCCAGCTACTTGGCCGAGGCAGAATTGCTTGAACCCGGGAGGCAGAGGTTGCAGTTAGCTAAGATCGTGCCACTGCACTCCAGCCTGGGCAACAGAACA...
pathogenic
230,884
Considering the variant on chromosome 15, location 43260232, involving gene TGM5 (transglutaminase 5), would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Acral_peeling_skin_syndrome']
AAACCTGCATGTTGTGCACACATACCATAGAACTTAACGTATAATAATAAAAAAAAGAAACCATTACAAAAAAAAAAAAGAAAAACTACCTGTTGGGTAGTATGCTTATTACCTGGGTAATAAAATAATGCGTACATCAAACCAAACCTCTGTGGTGTGCAATTTACCTACATAGCAAATCTGTATGTGTACCCCTGAACCTAAAATAAAGGTTAAAAATTATCTTTTTAAAGTTAAGAACAAACAAACAAAAGGCCATGGGCACAGACGTCCACTTTGCAGGGTCCTAGAACTGTCTGGAAACTCTGTCTGACCCTGAG...
AAACCTGCATGTTGTGCACACATACCATAGAACTTAACGTATAATAATAAAAAAAAGAAACCATTACAAAAAAAAAAAAGAAAAACTACCTGTTGGGTAGTATGCTTATTACCTGGGTAATAAAATAATGCGTACATCAAACCAAACCTCTGTGGTGTGCAATTTACCTACATAGCAAATCTGTATGTGTACCCCTGAACCTAAAATAAAGGTTAAAAATTATCTTTTTAAAGTTAAGAACAAACAAACAAAAGGCCATGGGCACAGACGTCCACTTTGCAGGGTCCTAGAACTGTCTGGAAACTCTGTCTGACCCTGAG...
pathogenic
231,088
Is the chromosome 15, position 43383359 variant in TUBGCP4 (tubulin gamma complex component 4) clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Microcephaly_and_chorioretinopathy_3']
CACATTTGATCTTTTTAAAGAGAGATTCCATTCAGTTAAATAACACAGTCAAGTTCTTGTAATTTCTTTTTCTCCCAACCTTTTATTTTGAAAAATTTTAAACCTACAAAAAAGTTGAAAGAAACGTATAATAAAACACTTGTAGGCTGGGCTCGGTGGCTCACGCTTGTAATCCCAGCACTTTGGAAGGCTGAGGCAGAGGGATCGCTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACATAGCGAGACCCTGTCTGTACCAAAAATAAAAAAATTAGCCAGGTGTGGTGCCTGCCTGTAGTCCCAGCTACGGGAAG...
CACATTTGATCTTTTTAAAGAGAGATTCCATTCAGTTAAATAACACAGTCAAGTTCTTGTAATTTCTTTTTCTCCCAACCTTTTATTTTGAAAAATTTTAAACCTACAAAAAAGTTGAAAGAAACGTATAATAAAACACTTGTAGGCTGGGCTCGGTGGCTCACGCTTGTAATCCCAGCACTTTGGAAGGCTGAGGCAGAGGGATCGCTTGAGCCCAGGAGTTCGAGACCAGCCTGGGCAACATAGCGAGACCCTGTCTGTACCAAAAATAAAAAAATTAGCCAGGTGTGGTGCCTGCCTGTAGTCCCAGCTACGGGAAG...
pathogenic
231,102
Variant in gene TUBGCP4 (tubulin gamma complex component 4), located at chromosome 15 position 43385777: benign or pathogenic? What disease(s) does it cause if pathogenic?
benign
ATTATAAGTCTTACTTATGTAGCTACTCTAATGGAGCAGCTAGCTACATTTTAGATTTTAAATACAGTTTGGAGTTTTGTTTTTTTTTTTAAAGACAGATTCTCACCCATCGCCCAGGCTGGAGTGCGATGGCGCAATCTTGGCTCACTGCAGCCACTGCCTCCCAGGTTCAAGCAATTCTCCTGCCTTAGCCTCCCAAGTACCTGGAACCAGGCATGTGCCACCATGCCTAGCTAATTTTCATATTTTTTATTTTCATATTTTTAGTAGAGACAGGGTTTTGTCATGTTGGCCAGGCTGGTCTCGAACGCCTGACCTCA...
ATTATAAGTCTTACTTATGTAGCTACTCTAATGGAGCAGCTAGCTACATTTTAGATTTTAAATACAGTTTGGAGTTTTGTTTTTTTTTTTAAAGACAGATTCTCACCCATCGCCCAGGCTGGAGTGCGATGGCGCAATCTTGGCTCACTGCAGCCACTGCCTCCCAGGTTCAAGCAATTCTCCTGCCTTAGCCTCCCAAGTACCTGGAACCAGGCATGTGCCACCATGCCTAGCTAATTTTCATATTTTTTATTTTCATATTTTTAGTAGAGACAGGGTTTTGTCATGTTGGCCAGGCTGGTCTCGAACGCCTGACCTCA...
benign
231,106
Located at chromosome 15 position 43386344, the variant affecting gene TUBGCP4 (tubulin gamma complex component 4)—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
benign
AGGGGAAGAGATATAGAAAAGTAAACAGTTACATTACAGTGTGCTAAGGGCTCTGAAAAGACTAAATATGGGTATTCTTGGAACATGGTCATGGGATAGGGTCTTGGAGTGACTAGGGAAGGCTTTTCAGTGGAAGGTATGTCTAAATTGCAAAGAGTTTGGGAGGAGCCATCAAGAGACATCCAGGCAGAAGGAATGATATGTGTAAAGGTACAGGGGCCATTAAGGACATGGTTCATTTGGGGAAACAGTAGTAATTCAATTGAAATGATCAAATAAAGGCTGAAGTAAAATGTTACAAGAGATGGTGTGAGGGAGAG...
AGGGGAAGAGATATAGAAAAGTAAACAGTTACATTACAGTGTGCTAAGGGCTCTGAAAAGACTAAATATGGGTATTCTTGGAACATGGTCATGGGATAGGGTCTTGGAGTGACTAGGGAAGGCTTTTCAGTGGAAGGTATGTCTAAATTGCAAAGAGTTTGGGAGGAGCCATCAAGAGACATCCAGGCAGAAGGAATGATATGTGTAAAGGTACAGGGGCCATTAAGGACATGGTTCATTTGGGGAAACAGTAGTAATTCAATTGAAATGATCAAATAAAGGCTGAAGTAAAATGTTACAAGAGATGGTGTGAGGGAGAG...
benign
231,115
Evaluate this variant at chromosome 15, position 43386344, gene TUBGCP4 (tubulin gamma complex component 4): benign or pathogenic? If pathogenic, what are the disease connection(s)?
benign
AGGGGAAGAGATATAGAAAAGTAAACAGTTACATTACAGTGTGCTAAGGGCTCTGAAAAGACTAAATATGGGTATTCTTGGAACATGGTCATGGGATAGGGTCTTGGAGTGACTAGGGAAGGCTTTTCAGTGGAAGGTATGTCTAAATTGCAAAGAGTTTGGGAGGAGCCATCAAGAGACATCCAGGCAGAAGGAATGATATGTGTAAAGGTACAGGGGCCATTAAGGACATGGTTCATTTGGGGAAACAGTAGTAATTCAATTGAAATGATCAAATAAAGGCTGAAGTAAAATGTTACAAGAGATGGTGTGAGGGAGAG...
AGGGGAAGAGATATAGAAAAGTAAACAGTTACATTACAGTGTGCTAAGGGCTCTGAAAAGACTAAATATGGGTATTCTTGGAACATGGTCATGGGATAGGGTCTTGGAGTGACTAGGGAAGGCTTTTCAGTGGAAGGTATGTCTAAATTGCAAAGAGTTTGGGAGGAGCCATCAAGAGACATCCAGGCAGAAGGAATGATATGTGTAAAGGTACAGGGGCCATTAAGGACATGGTTCATTTGGGGAAACAGTAGTAATTCAATTGAAATGATCAAATAAAGGCTGAAGTAAAATGTTACAAGAGATGGTGTGAGGGAGAG...
benign
231,117
Mutation found at chromosome 15 position 43386344, gene TUBGCP4 (tubulin gamma complex component 4): benign or pathogenic? If pathogenic, indicate the relevant disease(s).
benign
AGGGGAAGAGATATAGAAAAGTAAACAGTTACATTACAGTGTGCTAAGGGCTCTGAAAAGACTAAATATGGGTATTCTTGGAACATGGTCATGGGATAGGGTCTTGGAGTGACTAGGGAAGGCTTTTCAGTGGAAGGTATGTCTAAATTGCAAAGAGTTTGGGAGGAGCCATCAAGAGACATCCAGGCAGAAGGAATGATATGTGTAAAGGTACAGGGGCCATTAAGGACATGGTTCATTTGGGGAAACAGTAGTAATTCAATTGAAATGATCAAATAAAGGCTGAAGTAAAATGTTACAAGAGATGGTGTGAGGGAGAG...
AGGGGAAGAGATATAGAAAAGTAAACAGTTACATTACAGTGTGCTAAGGGCTCTGAAAAGACTAAATATGGGTATTCTTGGAACATGGTCATGGGATAGGGTCTTGGAGTGACTAGGGAAGGCTTTTCAGTGGAAGGTATGTCTAAATTGCAAAGAGTTTGGGAGGAGCCATCAAGAGACATCCAGGCAGAAGGAATGATATGTGTAAAGGTACAGGGGCCATTAAGGACATGGTTCATTTGGGGAAACAGTAGTAATTCAATTGAAATGATCAAATAAAGGCTGAAGTAAAATGTTACAAGAGATGGTGTGAGGGAGAG...
benign
231,118
The chromosome 15, position 43600915 genetic variant in gene STRC (stereocilin): benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_16', 'Rare_genetic_deafness']
AAAAACGTGGTACTGGAGGAGTGGACACTGCTGCTACAGGCGGTGTCTTTGATATTTCTAATTTGGACCGACTAGGCAAATCAGAGGTGAGATCCTAAGGGATTAGGACAAGGAGAGGTATAGGTCTGCGAGGGCCGAAATATGGCAGTGAGTGAGCCTCCGGGATGTAAGATAATCTGAAATGAAATTCAGGTTGAGTGGGGAGGCAATTGGAAATGAGCAGGCAAGTCAGTCAGTGATAAAGAAAAACTCAGACTGTAGGAAGCAGATCAAAGATTAGTGTCCCTTAGGTGGAGCTGGTGCAACTGGTCATCGATGGA...
AAAAACGTGGTACTGGAGGAGTGGACACTGCTGCTACAGGCGGTGTCTTTGATATTTCTAATTTGGACCGACTAGGCAAATCAGAGGTGAGATCCTAAGGGATTAGGACAAGGAGAGGTATAGGTCTGCGAGGGCCGAAATATGGCAGTGAGTGAGCCTCCGGGATGTAAGATAATCTGAAATGAAATTCAGGTTGAGTGGGGAGGCAATTGGAAATGAGCAGGCAAGTCAGTCAGTGATAAAGAAAAACTCAGACTGTAGGAAGCAGATCAAAGATTAGTGTCCCTTAGGTGGAGCTGGTGCAACTGGTCATCGATGGA...
pathogenic
231,159
Chromosome 15, position 43603276, gene STRC (stereocilin): Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_16', 'Rare_genetic_deafness']
TGAATAAATCAGAGTCCTGAAGGTCACTAGTATGGGGTATCAACAAAAGATAGAAAGAAGGACCAGGTAGGGTCACAGGAAAAAAATTCCTTGGGCTTTAGATGATCTATAGGGCTGGGTCTGTGGGATGGGTGTTTGGGAAGCCGTAGGGAGGAGGAAAAGTGTTACCTGAGTGGTGCTCCAGCCATCTATCTGCCCCAGGGTGCTCAGCACTCCCCAGTCCACTAGGATCAGCTCCTGTAGTTCCCGATCTCCTAGACCTATTAAGAGCCTACCAAGCTGCAGGATCTGCTCAGGACGAAATCCCCGGGGGGGACCCC...
TGAATAAATCAGAGTCCTGAAGGTCACTAGTATGGGGTATCAACAAAAGATAGAAAGAAGGACCAGGTAGGGTCACAGGAAAAAAATTCCTTGGGCTTTAGATGATCTATAGGGCTGGGTCTGTGGGATGGGTGTTTGGGAAGCCGTAGGGAGGAGGAAAAGTGTTACCTGAGTGGTGCTCCAGCCATCTATCTGCCCCAGGGTGCTCAGCACTCCCCAGTCCACTAGGATCAGCTCCTGTAGTTCCCGATCTCCTAGACCTATTAAGAGCCTACCAAGCTGCAGGATCTGCTCAGGACGAAATCCCCGGGGGGGACCCC...
pathogenic
231,167
Does the chromosome 15 mutation at position 43604119 within gene STRC (stereocilin) classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_16']
CACCACTGCACTCCAGCCTGGATGCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGGAGATGCAGATGTCTAGACTCTTTCCCCCAGAGGCTTATTTTTTAATTTATGAGACAGGGTCTTGCTCTGACACCCAGGCTGGAGGGCAGTGGTGCGATCTTGGCACATTGCACCCTCCACCTCCTGCACTCATGGGATTCTCCTACCCCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCGCCACACCCAGCTAATGTTTTTTCTATTTTTAGTAGAGACAGGGTTTCACCATGTTGC...
CACCACTGCACTCCAGCCTGGATGCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAGGAGATGCAGATGTCTAGACTCTTTCCCCCAGAGGCTTATTTTTTAATTTATGAGACAGGGTCTTGCTCTGACACCCAGGCTGGAGGGCAGTGGTGCGATCTTGGCACATTGCACCCTCCACCTCCTGCACTCATGGGATTCTCCTACCCCAGCCTCCTGAGTAGCTGGGATTACAGGCATGTGCCGCCACACCCAGCTAATGTTTTTTCTATTTTTAGTAGAGACAGGGTTTCACCATGTTGC...
pathogenic
231,176
A mutation at chromosome position 43609329 on chromosome 15 in gene STRC (stereocilin): benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Rare_genetic_deafness']
GGGGCCATCTGGCTTAGGCTCGAACAGCTCCAAGGACCAGGAACTCACTACCTTAGTTTTTCTTATACTATGTAAAAATCTGATCTCCGTTAACTACTCTTAGTCTTGCCCAATGGGGCCACTCATAAATATGACAATCTAATTTCTACTTGATAGCCCCTCAGGTATTTGAAGGTATTTATCACATTTTTCATATATTTTTCTCTCGATCTACTCCTCTGAATGCACTAAGAACACAGTGCCCTGAGCAAACTACAATCCTCTGGGGCAGATTTGGAGCATTGCCTCCCTCACTTCAGATGCTCTGTCTCAATCTCAAT...
GGGGCCATCTGGCTTAGGCTCGAACAGCTCCAAGGACCAGGAACTCACTACCTTAGTTTTTCTTATACTATGTAAAAATCTGATCTCCGTTAACTACTCTTAGTCTTGCCCAATGGGGCCACTCATAAATATGACAATCTAATTTCTACTTGATAGCCCCTCAGGTATTTGAAGGTATTTATCACATTTTTCATATATTTTTCTCTCGATCTACTCCTCTGAATGCACTAAGAACACAGTGCCCTGAGCAAACTACAATCCTCTGGGGCAGATTTGGAGCATTGCCTCCCTCACTTCAGATGCTCTGTCTCAATCTCAAT...
pathogenic
231,191
A genetic variant at chromosome 15, position 43614435, affecting gene STRC (stereocilin)—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Autosomal_recessive_nonsyndromic_hearing_loss_16']
GGGCTGAGGGTCCCATTGGCTGCACATTCCAGCAGCCCCCGTTCTACTGGCCCCGTTGGATCACTCAGGGGCACTAGGCTCTGCAGCTCCTCAGGGCTCAGGAAACAGGCGAGGGGCCCAAGCCTGAGGAGGGCATGAAGCTGACCTTTGTGTGGTCCCCAAGACTAGCACTAAGGCAGGCCTGGCAGCAGATGGTATGGGTACATACACTGGGCACTCTGACACTACACCACTACACAGGGGCACCATCTATAGACCTCTCTCCTGGAACTCTATGCTGCCTGAGGCCACTGCCTACTCTCTTGCCCCTTTCTTCCTAG...
GGGCTGAGGGTCCCATTGGCTGCACATTCCAGCAGCCCCCGTTCTACTGGCCCCGTTGGATCACTCAGGGGCACTAGGCTCTGCAGCTCCTCAGGGCTCAGGAAACAGGCGAGGGGCCCAAGCCTGAGGAGGGCATGAAGCTGACCTTTGTGTGGTCCCCAAGACTAGCACTAAGGCAGGCCTGGCAGCAGATGGTATGGGTACATACACTGGGCACTCTGACACTACACCACTACACAGGGGCACCATCTATAGACCTCTCTCCTGGAACTCTATGCTGCCTGAGGCCACTGCCTACTCTCTTGCCCCTTTCTTCCTAG...
pathogenic
231,198
Regarding the variant at chromosome 15 and position 43617959, affecting gene STRC (stereocilin): benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Deafness-infertility_syndrome', 'Rare_genetic_deafness']
GGCCAGAAGGGCACCAGGACCTCATACATGGTGTCATTGGCACAGACCATCACCAGGAAGCTGCCCCCATCCGGGCAGCGTTCCCCACAGGGTCCAATGTGGCATGGTGGGGAGGCAGTGACATCTGGGGTGGGGCCCTGGCACACATGCTGGACCCAAGCCTGGTTGCTGGGGGGCACAGCCTGTAGACTTGCCTCCCCACACAGTCGCTCAGCCCACAGAGTCTCATTCTCCAAGAAGCAGCCCCAAAAGATGTCTGGGGTGAGGGGAACAGGGGGCAGGCCTTCAGGGCAGCTGGTAGGGGGTGGGAGCAGGCCAGC...
GGCCAGAAGGGCACCAGGACCTCATACATGGTGTCATTGGCACAGACCATCACCAGGAAGCTGCCCCCATCCGGGCAGCGTTCCCCACAGGGTCCAATGTGGCATGGTGGGGAGGCAGTGACATCTGGGGTGGGGCCCTGGCACACATGCTGGACCCAAGCCTGGTTGCTGGGGGGCACAGCCTGTAGACTTGCCTCCCCACACAGTCGCTCAGCCCACAGAGTCTCATTCTCCAAGAAGCAGCCCCAAAAGATGTCTGGGGTGAGGGGAACAGGGGGCAGGCCTTCAGGGCAGCTGGTAGGGGGTGGGAGCAGGCCAGC...
pathogenic
231,202
Clinically, how would you classify the variant at chromosome 15, position 43618668, gene STRC (stereocilin): benign or pathogenic? If pathogenic, specify the associated illness(es).
benign
GGGGTGGGGGTGGTGATCCAGACAGAAAGCCCAGCGCCTGGACATCCCAGGAAAGGTTGTGCCGGACGCCCCTGGGTGCAGAGGGAGGAGCAGGCAGGATCTGGTCAGTTCACATTTCCTCCAGCTGAAGATTCTGACCCTGACTCAGAGCCCTCAAGGGGCATGGCAAGCATAGGCTTTTCTACAAGCGAGGTCCCTGAGAGTTTAGGCGTTACTGGTTGAAATGCTGCAACGGGGCAAAAAAGAGAAAGCTGCCCTGCCAAGGTCCAAAATCACCTAGGAGAAGCCCCAGTTGGAATTCTTTCTGTCCACCTGGCCCC...
GGGGTGGGGGTGGTGATCCAGACAGAAAGCCCAGCGCCTGGACATCCCAGGAAAGGTTGTGCCGGACGCCCCTGGGTGCAGAGGGAGGAGCAGGCAGGATCTGGTCAGTTCACATTTCCTCCAGCTGAAGATTCTGACCCTGACTCAGAGCCCTCAAGGGGCATGGCAAGCATAGGCTTTTCTACAAGCGAGGTCCCTGAGAGTTTAGGCGTTACTGGTTGAAATGCTGCAACGGGGCAAAAAAGAGAAAGCTGCCCTGCCAAGGTCCAAAATCACCTAGGAGAAGCCCCAGTTGGAATTCTTTCTGTCCACCTGGCCCC...
benign
231,205
Does the genetic variant at chromosome 15, position 44563310, impacting gene SPG11 (SPG11 vesicle trafficking associated, spatacsin), appear benign or pathogenic? If pathogenic, name the associated disease(s).
benign
TTTTGTGCTGGTTATTTAACCCCTTGACACTTAGGTGCTAATGTGCAAATGAGGGAACTTGGATCTTGCTGCCAAGGGGTTAAAATTGGGAACCTAAGTTGCTACTAAATCATAGTTCAAAACCTAATAATGTTGTCGTTGTTGCTATCTGATTTCATAGCAGCAGTCACTAAATTGGAAACAAAAGGTTGCAACGTGACAAAAAAAATTGTGTAGTATTTACCAGCACCATTCAGTAATACAGCCTTAACCATACCTCCTTGAACTACTTCATAACTTGTCAAGAAAAGCAGTTTGCAGCAAGGGCATGTGGTGTGCAC...
TTTTGTGCTGGTTATTTAACCCCTTGACACTTAGGTGCTAATGTGCAAATGAGGGAACTTGGATCTTGCTGCCAAGGGGTTAAAATTGGGAACCTAAGTTGCTACTAAATCATAGTTCAAAACCTAATAATGTTGTCGTTGTTGCTATCTGATTTCATAGCAGCAGTCACTAAATTGGAAACAAAAGGTTGCAACGTGACAAAAAAAATTGTGTAGTATTTACCAGCACCATTCAGTAATACAGCCTTAACCATACCTCCTTGAACTACTTCATAACTTGTCAAGAAAAGCAGTTTGCAGCAAGGGCATGTGGTGTGCAC...
benign
231,243
Evaluate this variant at chromosome 15, position 44564624, gene SPG11 (SPG11 vesicle trafficking associated, spatacsin): benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Hereditary_spastic_paraplegia_11', 'Inborn_genetic_diseases']
AGTGATTTGAGAAATTAACAAAAGTAGTGACTACACAGCAATAATTACAGTAAATTAAATAAAGATTCCTTTAAGGCAGACAAGGGCTAAGATTTCCTTAGCAGTAATAATGACATACACTGAATTGAAAATCTATTTTATTACAGAAAGATCAGTTTCTAACAAATGAAAATGTATCACCTGTTCCTTAACTGTGTAAATAATAATTAAATTTCTTTGAAACTGGAATCTGCAGGTACAGGTATTCTTTAATCATTATTGGATCATCTAAAGTAGAAGCTGTCCTGAGGAAGAGGAAGCTTTTGATCTTAATACTAGTA...
AGTGATTTGAGAAATTAACAAAAGTAGTGACTACACAGCAATAATTACAGTAAATTAAATAAAGATTCCTTTAAGGCAGACAAGGGCTAAGATTTCCTTAGCAGTAATAATGACATACACTGAATTGAAAATCTATTTTATTACAGAAAGATCAGTTTCTAACAAATGAAAATGTATCACCTGTTCCTTAACTGTGTAAATAATAATTAAATTTCTTTGAAACTGGAATCTGCAGGTACAGGTATTCTTTAATCATTATTGGATCATCTAAAGTAGAAGCTGTCCTGAGGAAGAGGAAGCTTTTGATCTTAATACTAGTA...
pathogenic
231,247
The mutation in gene SPG11 (SPG11 vesicle trafficking associated, spatacsin) at chromosome 15, position 44564700—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Hereditary_spastic_paraplegia', 'Hereditary_spastic_paraplegia_11']
CAGACAAGGGCTAAGATTTCCTTAGCAGTAATAATGACATACACTGAATTGAAAATCTATTTTATTACAGAAAGATCAGTTTCTAACAAATGAAAATGTATCACCTGTTCCTTAACTGTGTAAATAATAATTAAATTTCTTTGAAACTGGAATCTGCAGGTACAGGTATTCTTTAATCATTATTGGATCATCTAAAGTAGAAGCTGTCCTGAGGAAGAGGAAGCTTTTGATCTTAATACTAGTATCTATATAAAATGGTGTGGATGAACAATCATCTAAAATCAATCTATTTTAAATAGGAATTTCCTCCTGAAAAGTTT...
CAGACAAGGGCTAAGATTTCCTTAGCAGTAATAATGACATACACTGAATTGAAAATCTATTTTATTACAGAAAGATCAGTTTCTAACAAATGAAAATGTATCACCTGTTCCTTAACTGTGTAAATAATAATTAAATTTCTTTGAAACTGGAATCTGCAGGTACAGGTATTCTTTAATCATTATTGGATCATCTAAAGTAGAAGCTGTCCTGAGGAAGAGGAAGCTTTTGATCTTAATACTAGTATCTATATAAAATGGTGTGGATGAACAATCATCTAAAATCAATCTATTTTAAATAGGAATTTCCTCCTGAAAAGTTT...
pathogenic
231,249