question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Clinical classification of chromosome 2, position 178530457, gene TTN: benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
CATTTGAAGAAATAGAAATCTAAGACAAAGGAAAAAGAAAAGAAATGTTGAAGTTCTTCAGATGTGGAAGACATGGTATTTTAGTTTTTCTTCAATAATATATTCATAATTAAACTTACTGGCAGGTTGTTTTTAAACCATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAG...
CATTTGAAGAAATAGAAATCTAAGACAAAGGAAAAAGAAAAGAAATGTTGAAGTTCTTCAGATGTGGAAGACATGGTATTTTAGTTTTTCTTCAATAATATATTCATAATTAAACTTACTGGCAGGTTGTTTTTAAACCATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAG...
pathogenic
47,154
Considering the genetic mutation at chromosome 2, position 178530477, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TAAGACAAAGGAAAAAGAAAAGAAATGTTGAAGTTCTTCAGATGTGGAAGACATGGTATTTTAGTTTTTCTTCAATAATATATTCATAATTAAACTTACTGGCAGGTTGTTTTTAAACCATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGAC...
TAAGACAAAGGAAAAAGAAAAGAAATGTTGAAGTTCTTCAGATGTGGAAGACATGGTATTTTAGTTTTTCTTCAATAATATATTCATAATTAAACTTACTGGCAGGTTGTTTTTAAACCATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGAC...
pathogenic
47,156
Chromosome 2, position 178530499, gene TTN: Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AAATGTTGAAGTTCTTCAGATGTGGAAGACATGGTATTTTAGTTTTTCTTCAATAATATATTCATAATTAAACTTACTGGCAGGTTGTTTTTAAACCATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGACTGGCTTGCTTGATGGTTAGGGT...
AAATGTTGAAGTTCTTCAGATGTGGAAGACATGGTATTTTAGTTTTTCTTCAATAATATATTCATAATTAAACTTACTGGCAGGTTGTTTTTAAACCATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGACTGGCTTGCTTGATGGTTAGGGT...
pathogenic
47,159
Determine if the mutation at chromosome 2, position 178530565 in gene TTN is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy']
ATTAAACTTACTGGCAGGTTGTTTTTAAACCATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGACTGGCTTGCTTGATGGTTAGGGTCTGATCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTAC...
ATTAAACTTACTGGCAGGTTGTTTTTAAACCATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGACTGGCTTGCTTGATGGTTAGGGTCTGATCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTAC...
pathogenic
47,161
Variant on chromosome 2, at position 178530595, affecting TTN: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGACTGGCTTGCTTGATGGTTAGGGTCTGATCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTT...
CATTCGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGACTGGCTTGCTTGATGGTTAGGGTCTGATCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTT...
pathogenic
47,162
Is the genetic change at chromosome 2, position 178530599, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
CGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGACTGGCTTGCTTGATGGTTAGGGTCTGATCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCT...
CGATTTCAGGGGATGGCTCGCCACTGATTTCACAAGTAAAGAGAACATTTTGTCCTTCATTAATATTTTGAGATCTAGGCTGTGAGATGAAGGCTGGAGCATCTGAGAGTTCTTTGCTCAGTGTCAAATCATACTGACACTTGACGATTCCTTCCTTGGTTTTGCTTATGCAGGTGAGGATTCCTTCATCTCTGTGACTGGCTTGCTTGATGGTTAGGGTCTGATCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCT...
pathogenic
47,163
Variant at chromosome position 178530804, chromosome 2, gene TTN: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTTGATGGTTAGGGTCTGATCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCTTTTAAAACCAGTCTTTGACCTTCGTTTATGCTCATCTGAGTAGAAAATGCTTTAATCTCAGCATGAGTTCTGACTTCTTCTGATGCCTGTGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTT...
CTTGATGGTTAGGGTCTGATCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCTTTTAAAACCAGTCTTTGACCTTCGTTTATGCTCATCTGAGTAGAAAATGCTTTAATCTCAGCATGAGTTCTGACTTCTTCTGATGCCTGTGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTT...
pathogenic
47,169
Mutation at chromosome 2, position 178530823, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCTTTTAAAACCAGTCTTTGACCTTCGTTTATGCTCATCTGAGTAGAAAATGCTTTAATCTCAGCATGAGTTCTGACTTCTTCTGATGCCTGTGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGA...
TCGCTGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCTTTTAAAACCAGTCTTTGACCTTCGTTTATGCTCATCTGAGTAGAAAATGCTTTAATCTCAGCATGAGTTCTGACTTCTTCTGATGCCTGTGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGA...
pathogenic
47,170
Is the genetic change at chromosome 2, position 178530827, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
benign
TGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCTTTTAAAACCAGTCTTTGACCTTCGTTTATGCTCATCTGAGTAGAAAATGCTTTAATCTCAGCATGAGTTCTGACTTCTTCTGATGCCTGTGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGACATC...
TGCCTGAGACACCATATCGGTACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCTTTTAAAACCAGTCTTTGACCTTCGTTTATGCTCATCTGAGTAGAAAATGCTTTAATCTCAGCATGAGTTCTGACTTCTTCTGATGCCTGTGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGACATC...
benign
47,173
Clinically, how would you classify the variant at chromosome 2, position 178530848, gene TTN: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_familial_dilated_cardiomyopathy']
ACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCTTTTAAAACCAGTCTTTGACCTTCGTTTATGCTCATCTGAGTAGAAAATGCTTTAATCTCAGCATGAGTTCTGACTTCTTCTGATGCCTGTGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGACATCTTAATTTCTTCAGACCTTAGG...
ACTCCTCAGAGTTGGTAAGCTCTACGCCATTCAGTACCCATTTCACATCAGTGGCACCAGCAATGTTGGCTTTTAAAACCAGTCTTTGACCTTCGTTTATGCTCATCTGAGTAGAAAATGCTTTAATCTCAGCATGAGTTCTGACTTCTTCTGATGCCTGTGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGACATCTTAATTTCTTCAGACCTTAGG...
pathogenic
47,179
Variant chromosome 2, position 178531008, gene TTN: benign or pathogenic? Disease(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
TGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGACATCTTAATTTCTTCAGACCTTAGGGCTTTTTGGGAAATTTCCTCTTGGACAACAGCTTTCTTCTGAGGTGTAATTTCAGAAGTCTTTTGTGTAGAGACTTTCTGTGCCTCAGTATCTTTTATAGCTAAAAAAGAAACCTCTGTAAGGCAAACTTAATTAGAAAGAGACCCCCACCTTTTACTCT...
TGATGTTTTAGTGATTTCCTCATGGACAATGGATTTTTCCAGGGAGGTTGCTGCTGATTTCTTGACTTCTTCAGAAATCAGAACCTTTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGACATCTTAATTTCTTCAGACCTTAGGGCTTTTTGGGAAATTTCCTCTTGGACAACAGCTTTCTTCTGAGGTGTAATTTCAGAAGTCTTTTGTGTAGAGACTTTCTGTGCCTCAGTATCTTTTATAGCTAAAAAAGAAACCTCTGTAAGGCAAACTTAATTAGAAAGAGACCCCCACCTTTTACTCT...
pathogenic
47,184
Chromosome 2, position 178531094, gene TTN: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J']
TTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGACATCTTAATTTCTTCAGACCTTAGGGCTTTTTGGGAAATTTCCTCTTGGACAACAGCTTTCTTCTGAGGTGTAATTTCAGAAGTCTTTTGTGTAGAGACTTTCTGTGCCTCAGTATCTTTTATAGCTAAAAAAGAAACCTCTGTAAGGCAAACTTAATTAGAAAGAGACCCCCACCTTTTACTCTTCTAGATTCTGCGTGTGAAAAACATAAAAAGAAAAAAAGTCAACTTCTTCATGCAATGTAGGTAATACCTAATACTTTCTCAGTTC...
TTGAAGCTTCCTCTTTGAGGGCTAACTTTTCTTGAGATTTTGCCTCTGACATCTTAATTTCTTCAGACCTTAGGGCTTTTTGGGAAATTTCCTCTTGGACAACAGCTTTCTTCTGAGGTGTAATTTCAGAAGTCTTTTGTGTAGAGACTTTCTGTGCCTCAGTATCTTTTATAGCTAAAAAAGAAACCTCTGTAAGGCAAACTTAATTAGAAAGAGACCCCCACCTTTTACTCTTCTAGATTCTGCGTGTGAAAAACATAAAAAGAAAAAAAGTCAACTTCTTCATGCAATGTAGGTAATACCTAATACTTTCTCAGTTC...
pathogenic
47,189
Does the variant impacting TTN on chromosome 2, position 178531192, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
ACAACAGCTTTCTTCTGAGGTGTAATTTCAGAAGTCTTTTGTGTAGAGACTTTCTGTGCCTCAGTATCTTTTATAGCTAAAAAAGAAACCTCTGTAAGGCAAACTTAATTAGAAAGAGACCCCCACCTTTTACTCTTCTAGATTCTGCGTGTGAAAAACATAAAAAGAAAAAAAGTCAACTTCTTCATGCAATGTAGGTAATACCTAATACTTTCTCAGTTCCACTTTTGGAAAATTATCATGTGTGACTTTTGAGATCACTGTAATGATTCCTTAAACTAAACTGAGCCAAAGATGATTCATATGACTTAAGGAAAAAA...
ACAACAGCTTTCTTCTGAGGTGTAATTTCAGAAGTCTTTTGTGTAGAGACTTTCTGTGCCTCAGTATCTTTTATAGCTAAAAAAGAAACCTCTGTAAGGCAAACTTAATTAGAAAGAGACCCCCACCTTTTACTCTTCTAGATTCTGCGTGTGAAAAACATAAAAAGAAAAAAAGTCAACTTCTTCATGCAATGTAGGTAATACCTAATACTTTCTCAGTTCCACTTTTGGAAAATTATCATGTGTGACTTTTGAGATCACTGTAATGATTCCTTAAACTAAACTGAGCCAAAGATGATTCATATGACTTAAGGAAAAAA...
pathogenic
47,199
Variant chromosome 2, position 178531423, gene TTN: benign or pathogenic? Disease(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Primary_dilated_cardiomyopathy', 'Tibial_mu...
AAAATTATCATGTGTGACTTTTGAGATCACTGTAATGATTCCTTAAACTAAACTGAGCCAAAGATGATTCATATGACTTAAGGAAAAAAGTCTTGAAAAGAATAGTCAACGGATTTAGGAGATAAGTGGATTTGGGAGATTTTGAGTAACCAAAACATTAAATTATCTTTCAGAAGATTGAAATGAAAGCAAACTAATTTTAATTGGTAAAATAGAAATAGTTCTTTAATTAACTTTGCACTGCTTTGGAAAATTAGCAACTGTGAAGGTTTAGGCAAGTAGTGCCATTTTGTATATTCACTGACTTTATTCTTAAATAT...
AAAATTATCATGTGTGACTTTTGAGATCACTGTAATGATTCCTTAAACTAAACTGAGCCAAAGATGATTCATATGACTTAAGGAAAAAAGTCTTGAAAAGAATAGTCAACGGATTTAGGAGATAAGTGGATTTGGGAGATTTTGAGTAACCAAAACATTAAATTATCTTTCAGAAGATTGAAATGAAAGCAAACTAATTTTAATTGGTAAAATAGAAATAGTTCTTTAATTAACTTTGCACTGCTTTGGAAAATTAGCAACTGTGAAGGTTTAGGCAAGTAGTGCCATTTTGTATATTCACTGACTTTATTCTTAAATAT...
pathogenic
47,209
Variant at chromosome position 178531453, chromosome 2, gene TTN: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGTAATGATTCCTTAAACTAAACTGAGCCAAAGATGATTCATATGACTTAAGGAAAAAAGTCTTGAAAAGAATAGTCAACGGATTTAGGAGATAAGTGGATTTGGGAGATTTTGAGTAACCAAAACATTAAATTATCTTTCAGAAGATTGAAATGAAAGCAAACTAATTTTAATTGGTAAAATAGAAATAGTTCTTTAATTAACTTTGCACTGCTTTGGAAAATTAGCAACTGTGAAGGTTTAGGCAAGTAGTGCCATTTTGTATATTCACTGACTTTATTCTTAAATATTCCTGGGAGCAGGGGCTGACACTATGGAAT...
TGTAATGATTCCTTAAACTAAACTGAGCCAAAGATGATTCATATGACTTAAGGAAAAAAGTCTTGAAAAGAATAGTCAACGGATTTAGGAGATAAGTGGATTTGGGAGATTTTGAGTAACCAAAACATTAAATTATCTTTCAGAAGATTGAAATGAAAGCAAACTAATTTTAATTGGTAAAATAGAAATAGTTCTTTAATTAACTTTGCACTGCTTTGGAAAATTAGCAACTGTGAAGGTTTAGGCAAGTAGTGCCATTTTGTATATTCACTGACTTTATTCTTAAATATTCCTGGGAGCAGGGGCTGACACTATGGAAT...
pathogenic
47,212
Located at chromosome 2 position 178531738, the variant affecting gene TTN—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
AATATTCCTGGGAGCAGGGGCTGACACTATGGAATCTTATATAATACCACATATAACTAGGTACTTAATAACTGCTTTTTATGCTCATAGAAAAGCATATGCTAACTTCAAATGTGTGTTTCTGCTTTGGTGTACAAATTGTATTCTGGAATTAGGAAAATAATTTTATTTTAATACTTTCTTGTATGTGTATATAAGGGGGGATGTTTGAAAATATTTCCCTAATATTATCTTCTGAAGAAATGTGGGTAAAAACAAAAGCCAACCTACCTTTTATTGTTAATTTGCAGCTAGAGGACACAGATCCAGCTGAATTTTTT...
AATATTCCTGGGAGCAGGGGCTGACACTATGGAATCTTATATAATACCACATATAACTAGGTACTTAATAACTGCTTTTTATGCTCATAGAAAAGCATATGCTAACTTCAAATGTGTGTTTCTGCTTTGGTGTACAAATTGTATTCTGGAATTAGGAAAATAATTTTATTTTAATACTTTCTTGTATGTGTATATAAGGGGGGATGTTTGAAAATATTTCCCTAATATTATCTTCTGAAGAAATGTGGGTAAAAACAAAAGCCAACCTACCTTTTATTGTTAATTTGCAGCTAGAGGACACAGATCCAGCTGAATTTTTT...
pathogenic
47,228
Mutation at chromosome 2, position 178532215, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy', 'TTN-related_myopathy']
TTTTTTGGGAAGCTGAATTTAGAAGATAAAATATTTTAGAAGATAAAAGAAAGAGACATTTAAGAACTGGTTACCTTTCCATCTTTTGTCCAGATGGCAGTTGGCCGGGGTTCTCCAGTAGCCTTAACTGCAAATTTAGCAACACTGTCTGAAGAAACAGTTGTATCCTGCAACCCAGTAACAATTACTGGTTTTGAGGAAATTGGTTCAGGAGCTTTTGGTTCAGTTTTTCTGGTTACTGTTGACTCAGTGGTTTTCTGATCTGATTTCTTAGTTTCTGATATTTTTGATACCTTCTCATGGATACTCTTAAAGGCTTG...
TTTTTTGGGAAGCTGAATTTAGAAGATAAAATATTTTAGAAGATAAAAGAAAGAGACATTTAAGAACTGGTTACCTTTCCATCTTTTGTCCAGATGGCAGTTGGCCGGGGTTCTCCAGTAGCCTTAACTGCAAATTTAGCAACACTGTCTGAAGAAACAGTTGTATCCTGCAACCCAGTAACAATTACTGGTTTTGAGGAAATTGGTTCAGGAGCTTTTGGTTCAGTTTTTCTGGTTACTGTTGACTCAGTGGTTTTCTGATCTGATTTCTTAGTTTCTGATATTTTTGATACCTTCTCATGGATACTCTTAAAGGCTTG...
pathogenic
47,247
Gene TTN variant at chromosome 2, position 178532440—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GTTTTTCTGGTTACTGTTGACTCAGTGGTTTTCTGATCTGATTTCTTAGTTTCTGATATTTTTGATACCTTCTCATGGATACTCTTAAAGGCTTGCCCCATAAATTGTAAGTTGGTTTTAGACGTTCCACCTTCACCAGAAATCTCACAAACATATTCTCCTTGATCAGATTCAGTGAGGTTATTGATTTTGAGCTCATAGGTACCATCTGCTGAATAATGAAACTGGAAATGCCCATTTTCCTTCAGTTTCTTGCCATCTTTATACCAGGTGACCTCTTTTGCCCTTAATACACTGCTTTCAACCACACAGGTCAGTTT...
GTTTTTCTGGTTACTGTTGACTCAGTGGTTTTCTGATCTGATTTCTTAGTTTCTGATATTTTTGATACCTTCTCATGGATACTCTTAAAGGCTTGCCCCATAAATTGTAAGTTGGTTTTAGACGTTCCACCTTCACCAGAAATCTCACAAACATATTCTCCTTGATCAGATTCAGTGAGGTTATTGATTTTGAGCTCATAGGTACCATCTGCTGAATAATGAAACTGGAAATGCCCATTTTCCTTCAGTTTCTTGCCATCTTTATACCAGGTGACCTCTTTTGCCCTTAATACACTGCTTTCAACCACACAGGTCAGTTT...
pathogenic
47,256
Clinical impact (benign or pathogenic) of the variant at chromosome 2, location 178532527, gene TTN: what disease(s) if pathogenic?
pathogenic; ['Cardiovascular_phenotype']
AAGGCTTGCCCCATAAATTGTAAGTTGGTTTTAGACGTTCCACCTTCACCAGAAATCTCACAAACATATTCTCCTTGATCAGATTCAGTGAGGTTATTGATTTTGAGCTCATAGGTACCATCTGCTGAATAATGAAACTGGAAATGCCCATTTTCCTTCAGTTTCTTGCCATCTTTATACCAGGTGACCTCTTTTGCCCTTAATACACTGCTTTCAACCACACAGGTCAGTTTTGCAATCTCTTTAGAAGCTTCTGCTTTCAGGAACTGAGTAATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGG...
AAGGCTTGCCCCATAAATTGTAAGTTGGTTTTAGACGTTCCACCTTCACCAGAAATCTCACAAACATATTCTCCTTGATCAGATTCAGTGAGGTTATTGATTTTGAGCTCATAGGTACCATCTGCTGAATAATGAAACTGGAAATGCCCATTTTCCTTCAGTTTCTTGCCATCTTTATACCAGGTGACCTCTTTTGCCCTTAATACACTGCTTTCAACCACACAGGTCAGTTTTGCAATCTCTTTAGAAGCTTCTGCTTTCAGGAACTGAGTAATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGG...
pathogenic
47,258
Evaluate the clinical significance of the mutation at chromosome 2, position 178532545 in gene TTN: benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGTAAGTTGGTTTTAGACGTTCCACCTTCACCAGAAATCTCACAAACATATTCTCCTTGATCAGATTCAGTGAGGTTATTGATTTTGAGCTCATAGGTACCATCTGCTGAATAATGAAACTGGAAATGCCCATTTTCCTTCAGTTTCTTGCCATCTTTATACCAGGTGACCTCTTTTGCCCTTAATACACTGCTTTCAACCACACAGGTCAGTTTTGCAATCTCTTTAGAAGCTTCTGCTTTCAGGAACTGAGTAATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGGTGTTGGTTTTGTCTCTGT...
TGTAAGTTGGTTTTAGACGTTCCACCTTCACCAGAAATCTCACAAACATATTCTCCTTGATCAGATTCAGTGAGGTTATTGATTTTGAGCTCATAGGTACCATCTGCTGAATAATGAAACTGGAAATGCCCATTTTCCTTCAGTTTCTTGCCATCTTTATACCAGGTGACCTCTTTTGCCCTTAATACACTGCTTTCAACCACACAGGTCAGTTTTGCAATCTCTTTAGAAGCTTCTGCTTTCAGGAACTGAGTAATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGGTGTTGGTTTTGTCTCTGT...
pathogenic
47,259
Chromosome 2, position 178532583, gene TTN: Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTCACAAACATATTCTCCTTGATCAGATTCAGTGAGGTTATTGATTTTGAGCTCATAGGTACCATCTGCTGAATAATGAAACTGGAAATGCCCATTTTCCTTCAGTTTCTTGCCATCTTTATACCAGGTGACCTCTTTTGCCCTTAATACACTGCTTTCAACCACACAGGTCAGTTTTGCAATCTCTTTAGAAGCTTCTGCTTTCAGGAACTGAGTAATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGGTGTTGGTTTTGTCTCTGTGGGTGATACGGCTTTCGGGTGAGAAGGTTCTGGAGATT...
CTCACAAACATATTCTCCTTGATCAGATTCAGTGAGGTTATTGATTTTGAGCTCATAGGTACCATCTGCTGAATAATGAAACTGGAAATGCCCATTTTCCTTCAGTTTCTTGCCATCTTTATACCAGGTGACCTCTTTTGCCCTTAATACACTGCTTTCAACCACACAGGTCAGTTTTGCAATCTCTTTAGAAGCTTCTGCTTTCAGGAACTGAGTAATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGGTGTTGGTTTTGTCTCTGTGGGTGATACGGCTTTCGGGTGAGAAGGTTCTGGAGATT...
pathogenic
47,261
Is the variant located on chromosome 2 at position 178532765, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TCTCTTTAGAAGCTTCTGCTTTCAGGAACTGAGTAATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGGTGTTGGTTTTGTCTCTGTGGGTGATACGGCTTTCGGGTGAGAAGGTTCTGGAGATTTCACTCGTTTTGGAGACTTAACTGCTTCTGGGGATTTCACCCGAGGCTCTGGGGATTTGACTCTTGGTGGTGATGTCACAGCCTTTTCAGTTACCCTGGCCTTTTGAATAGTCAGAGTGAACTCTGCTTCTTGTTTCCCTTCACTGTTTTCTACCACCACGCTGTAATTGCCCTCATCGGAA...
TCTCTTTAGAAGCTTCTGCTTTCAGGAACTGAGTAATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGGTGTTGGTTTTGTCTCTGTGGGTGATACGGCTTTCGGGTGAGAAGGTTCTGGAGATTTCACTCGTTTTGGAGACTTAACTGCTTCTGGGGATTTCACCCGAGGCTCTGGGGATTTGACTCTTGGTGGTGATGTCACAGCCTTTTCAGTTACCCTGGCCTTTTGAATAGTCAGAGTGAACTCTGCTTCTTGTTTCCCTTCACTGTTTTCTACCACCACGCTGTAATTGCCCTCATCGGAA...
pathogenic
47,265
Benign or pathogenic: chromosome 2, position 178532800, gene TTN variant? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
ATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGGTGTTGGTTTTGTCTCTGTGGGTGATACGGCTTTCGGGTGAGAAGGTTCTGGAGATTTCACTCGTTTTGGAGACTTAACTGCTTCTGGGGATTTCACCCGAGGCTCTGGGGATTTGACTCTTGGTGGTGATGTCACAGCCTTTTCAGTTACCCTGGCCTTTTGAATAGTCAGAGTGAACTCTGCTTCTTGTTTCCCTTCACTGTTTTCTACCACCACGCTGTAATTGCCCTCATCGGAAGCCTGGACTGAAGAGATCTCAAAGGTTGATTTGTA...
ATCTTTGGTGGGGCAGAGACTGGGAGGTGCTGAACTTTCTCTGTTGGTGTTGGTTTTGTCTCTGTGGGTGATACGGCTTTCGGGTGAGAAGGTTCTGGAGATTTCACTCGTTTTGGAGACTTAACTGCTTCTGGGGATTTCACCCGAGGCTCTGGGGATTTGACTCTTGGTGGTGATGTCACAGCCTTTTCAGTTACCCTGGCCTTTTGAATAGTCAGAGTGAACTCTGCTTCTTGTTTCCCTTCACTGTTTTCTACCACCACGCTGTAATTGCCCTCATCGGAAGCCTGGACTGAAGAGATCTCAAAGGTTGATTTGTA...
pathogenic
47,267
Variant at chromosome 2, position 178532855, gene TTN: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTGTCTCTGTGGGTGATACGGCTTTCGGGTGAGAAGGTTCTGGAGATTTCACTCGTTTTGGAGACTTAACTGCTTCTGGGGATTTCACCCGAGGCTCTGGGGATTTGACTCTTGGTGGTGATGTCACAGCCTTTTCAGTTACCCTGGCCTTTTGAATAGTCAGAGTGAACTCTGCTTCTTGTTTCCCTTCACTGTTTTCTACCACCACGCTGTAATTGCCCTCATCGGAAGCCTGGACTGAAGAGATCTCAAAGGTTGATTTGTACTTTGTGGTGGTCACTTGGTGGCGGGCAGAAGTACTTAGCACTTGTCCTTTACGC...
TTGTCTCTGTGGGTGATACGGCTTTCGGGTGAGAAGGTTCTGGAGATTTCACTCGTTTTGGAGACTTAACTGCTTCTGGGGATTTCACCCGAGGCTCTGGGGATTTGACTCTTGGTGGTGATGTCACAGCCTTTTCAGTTACCCTGGCCTTTTGAATAGTCAGAGTGAACTCTGCTTCTTGTTTCCCTTCACTGTTTTCTACCACCACGCTGTAATTGCCCTCATCGGAAGCCTGGACTGAAGAGATCTCAAAGGTTGATTTGTACTTTGTGGTGGTCACTTGGTGGCGGGCAGAAGTACTTAGCACTTGTCCTTTACGC...
pathogenic
47,272
The mutation in gene TTN at chromosome 2, position 178533254—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Decreased_patellar_reflex', 'Dilated_cardiomyopathy_1G', 'Hypertrophic_cardiomyopathy_9', 'Left_ventricular_noncompaction_cardiomyopathy', 'Limb-girdle_muscular_dystrophy', 'Muscular_dystrophy', 'Primary_dilated_card...
ACCGTGGCTTTGTTAGAATTCTTGCTGCCAAAGTCGTCTTGATCTTTCTGGTTGTGGATTTTTCTTCCAGTGACTTTTCTTCTAATGCAGCACTTTTCATTTCTGCAGATGCAGAGTGTTCATATGAGGAGAGACTTTCCCTTGTCTCCGTCATCTGTGATTTCACTTCCCTGACAGAAGACGAAGCTTCCATCTCAGATGTTTTCTTAAATGATGAAACAGCATACGCCTCTGTTCTTGTCAGCTCAGGGAAAACAGATCTGGGGACCTCTTCATCTCTGCGTTGGGAAGCATAGGTGGTATAATCCCCTCCTGTCACG...
ACCGTGGCTTTGTTAGAATTCTTGCTGCCAAAGTCGTCTTGATCTTTCTGGTTGTGGATTTTTCTTCCAGTGACTTTTCTTCTAATGCAGCACTTTTCATTTCTGCAGATGCAGAGTGTTCATATGAGGAGAGACTTTCCCTTGTCTCCGTCATCTGTGATTTCACTTCCCTGACAGAAGACGAAGCTTCCATCTCAGATGTTTTCTTAAATGATGAAACAGCATACGCCTCTGTTCTTGTCAGCTCAGGGAAAACAGATCTGGGGACCTCTTCATCTCTGCGTTGGGAAGCATAGGTGGTATAATCCCCTCCTGTCACG...
pathogenic
47,292
Is the genetic mutation found on chromosome 2 at position 178533553, within the gene TTN, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GTATAATCCCCTCCTGTCACGTCCAACGTTGCATAGTCAGAAGCTTCGCCCTTGTAGTTGGTGCACACAGCACGGTAGGTTCCACTGTCATCAGTATGACAGTCCAGAATTTCCAGGGTGAGGACTCCACTCGTGTTGGTGTAATGAATCTTACTGCTTTCTTGGAGTTCCACACCATTGTGGTACCATTTAACCTCGGCAGTTGGCTTAGACTGAACATTTAAAATAAAACGTGTATTTTGGCCACATGGTACCCTGTGCGAGCGCATTCTCAGTGTGATTCGAGGGGCATGGTCCAGTGTGAAAGGCTGCTGACTCAA...
GTATAATCCCCTCCTGTCACGTCCAACGTTGCATAGTCAGAAGCTTCGCCCTTGTAGTTGGTGCACACAGCACGGTAGGTTCCACTGTCATCAGTATGACAGTCCAGAATTTCCAGGGTGAGGACTCCACTCGTGTTGGTGTAATGAATCTTACTGCTTTCTTGGAGTTCCACACCATTGTGGTACCATTTAACCTCGGCAGTTGGCTTAGACTGAACATTTAAAATAAAACGTGTATTTTGGCCACATGGTACCCTGTGCGAGCGCATTCTCAGTGTGATTCGAGGGGCATGGTCCAGTGTGAAAGGCTGCTGACTCAA...
pathogenic
47,304
A genetic alteration at chromosome 2, position 178533571, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G']
ACGTCCAACGTTGCATAGTCAGAAGCTTCGCCCTTGTAGTTGGTGCACACAGCACGGTAGGTTCCACTGTCATCAGTATGACAGTCCAGAATTTCCAGGGTGAGGACTCCACTCGTGTTGGTGTAATGAATCTTACTGCTTTCTTGGAGTTCCACACCATTGTGGTACCATTTAACCTCGGCAGTTGGCTTAGACTGAACATTTAAAATAAAACGTGTATTTTGGCCACATGGTACCCTGTGCGAGCGCATTCTCAGTGTGATTCGAGGGGCATGGTCCAGTGTGAAAGGCTGCTGACTCAAAACTTCATACTTCCTTTC...
ACGTCCAACGTTGCATAGTCAGAAGCTTCGCCCTTGTAGTTGGTGCACACAGCACGGTAGGTTCCACTGTCATCAGTATGACAGTCCAGAATTTCCAGGGTGAGGACTCCACTCGTGTTGGTGTAATGAATCTTACTGCTTTCTTGGAGTTCCACACCATTGTGGTACCATTTAACCTCGGCAGTTGGCTTAGACTGAACATTTAAAATAAAACGTGTATTTTGGCCACATGGTACCCTGTGCGAGCGCATTCTCAGTGTGATTCGAGGGGCATGGTCCAGTGTGAAAGGCTGCTGACTCAAAACTTCATACTTCCTTTC...
pathogenic
47,305
Does the chromosome 2 mutation at position 178533865 within gene TTN classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TGACTCAAAACTTCATACTTCCTTTCTGATGTCTTCTGAGTTTTTAAAGCAGCTTTCATGGACTCATACCTGGAAAAGATATCAAATCTTGCAGACCTCTCAAATCTCGAGAGTGATCTCTCACTAGACACAGGGCTGGGGGATCGTGGGCGAGTTCTCTCTGGAGTAGGTGACCTTCTTTCTGTGTCATCTTCGTATTCCTCAGCCGGTTGTGGACGTGACCGGATCAGCTCAGACACTGGCCTCATTAACTCAATATAAGTTGGAGACAGGGAGCGCCGTCGTCTCAGTAGTCTAGACGCAGATGAGGATGATTCTCT...
TGACTCAAAACTTCATACTTCCTTTCTGATGTCTTCTGAGTTTTTAAAGCAGCTTTCATGGACTCATACCTGGAAAAGATATCAAATCTTGCAGACCTCTCAAATCTCGAGAGTGATCTCTCACTAGACACAGGGCTGGGGGATCGTGGGCGAGTTCTCTCTGGAGTAGGTGACCTTCTTTCTGTGTCATCTTCGTATTCCTCAGCCGGTTGTGGACGTGACCGGATCAGCTCAGACACTGGCCTCATTAACTCAATATAAGTTGGAGACAGGGAGCGCCGTCGTCTCAGTAGTCTAGACGCAGATGAGGATGATTCTCT...
pathogenic
47,313
Considering the genetic mutation at chromosome 2, position 178534344, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CAACTCTTCATCCTCCCTCTCAGCCATGATTCTTTGCCGTTGCTTTGGCTGTCTGTACGCAGCCTGGGCATGCCGTTCCCTCAGTTCTGCATAACTTGTACTAGCTTCAGCCTTCGTTGGGATGTGATAGGTTGAATACCTGAAGTCTTTTCTTGTTTCCTCCACCTTGACATGAGCTTGTGGTGAAGAGTAACGTAGGCTAGAAAGCTCAAAGTGTGGAGGGCTTCGACTTGGGGGTGAAGCTGAAAAACCTAACTCAAGCTCTTCTTCAAGACGCAGCCTCTCTTCCTCTGTTCTTTTCATTGCTAAGTAGTCATCAA...
CAACTCTTCATCCTCCCTCTCAGCCATGATTCTTTGCCGTTGCTTTGGCTGTCTGTACGCAGCCTGGGCATGCCGTTCCCTCAGTTCTGCATAACTTGTACTAGCTTCAGCCTTCGTTGGGATGTGATAGGTTGAATACCTGAAGTCTTTTCTTGTTTCCTCCACCTTGACATGAGCTTGTGGTGAAGAGTAACGTAGGCTAGAAAGCTCAAAGTGTGGAGGGCTTCGACTTGGGGGTGAAGCTGAAAAACCTAACTCAAGCTCTTCTTCAAGACGCAGCCTCTCTTCCTCTGTTCTTTTCATTGCTAAGTAGTCATCAA...
pathogenic
47,331
Considering the variant on chromosome 2, location 178534377, involving gene TTN, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTGCCGTTGCTTTGGCTGTCTGTACGCAGCCTGGGCATGCCGTTCCCTCAGTTCTGCATAACTTGTACTAGCTTCAGCCTTCGTTGGGATGTGATAGGTTGAATACCTGAAGTCTTTTCTTGTTTCCTCCACCTTGACATGAGCTTGTGGTGAAGAGTAACGTAGGCTAGAAAGCTCAAAGTGTGGAGGGCTTCGACTTGGGGGTGAAGCTGAAAAACCTAACTCAAGCTCTTCTTCAAGACGCAGCCTCTCTTCCTCTGTTCTTTTCATTGCTAAGTAGTCATCAATGGGGAGGAGTAATTCTTCATCAGAGATGTCCC...
TTGCCGTTGCTTTGGCTGTCTGTACGCAGCCTGGGCATGCCGTTCCCTCAGTTCTGCATAACTTGTACTAGCTTCAGCCTTCGTTGGGATGTGATAGGTTGAATACCTGAAGTCTTTTCTTGTTTCCTCCACCTTGACATGAGCTTGTGGTGAAGAGTAACGTAGGCTAGAAAGCTCAAAGTGTGGAGGGCTTCGACTTGGGGGTGAAGCTGAAAAACCTAACTCAAGCTCTTCTTCAAGACGCAGCCTCTCTTCCTCTGTTCTTTTCATTGCTAAGTAGTCATCAATGGGGAGGAGTAATTCTTCATCAGAGATGTCCC...
pathogenic
47,333
Mutation at chromosome 2, position 178534557, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GTGTGGAGGGCTTCGACTTGGGGGTGAAGCTGAAAAACCTAACTCAAGCTCTTCTTCAAGACGCAGCCTCTCTTCCTCTGTTCTTTTCATTGCTAAGTAGTCATCAATGGGGAGGAGTAATTCTTCATCAGAGATGTCCCCAAGAGAACGTCTTCTAGGTCGGTAGTAAAAGTCATAATCAGGAGAAGGTGTACGCCGGCGGGCTGGTCTCACTATCTCAAGATCATCTTGGGACAGTTTAGGAATACGCCATTTAGGTCTGTATTGATCTGTAATGCGTGGAAGAGGCATCACATAGAACTGTTCCCATCTTGAAAGGC...
GTGTGGAGGGCTTCGACTTGGGGGTGAAGCTGAAAAACCTAACTCAAGCTCTTCTTCAAGACGCAGCCTCTCTTCCTCTGTTCTTTTCATTGCTAAGTAGTCATCAATGGGGAGGAGTAATTCTTCATCAGAGATGTCCCCAAGAGAACGTCTTCTAGGTCGGTAGTAAAAGTCATAATCAGGAGAAGGTGTACGCCGGCGGGCTGGTCTCACTATCTCAAGATCATCTTGGGACAGTTTAGGAATACGCCATTTAGGTCTGTATTGATCTGTAATGCGTGGAAGAGGCATCACATAGAACTGTTCCCATCTTGAAAGGC...
pathogenic
47,345
Chromosome 2, position 178534621, gene TTN: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGCCTCTCTTCCTCTGTTCTTTTCATTGCTAAGTAGTCATCAATGGGGAGGAGTAATTCTTCATCAGAGATGTCCCCAAGAGAACGTCTTCTAGGTCGGTAGTAAAAGTCATAATCAGGAGAAGGTGTACGCCGGCGGGCTGGTCTCACTATCTCAAGATCATCTTGGGACAGTTTAGGAATACGCCATTTAGGTCTGTATTGATCTGTAATGCGTGGAAGAGGCATCACATAGAACTGTTCCCATCTTGAAAGGCGGATGCGCTTGGGTCGTTTCTGTACAACTCTGTCAAGTTTCCCAGGCATTTCATACTGATCACG...
AGCCTCTCTTCCTCTGTTCTTTTCATTGCTAAGTAGTCATCAATGGGGAGGAGTAATTCTTCATCAGAGATGTCCCCAAGAGAACGTCTTCTAGGTCGGTAGTAAAAGTCATAATCAGGAGAAGGTGTACGCCGGCGGGCTGGTCTCACTATCTCAAGATCATCTTGGGACAGTTTAGGAATACGCCATTTAGGTCTGTATTGATCTGTAATGCGTGGAAGAGGCATCACATAGAACTGTTCCCATCTTGAAAGGCGGATGCGCTTGGGTCGTTTCTGTACAACTCTGTCAAGTTTCCCAGGCATTTCATACTGATCACG...
pathogenic
47,348
Gene TTN variant at chromosome position 178534825 on chromosome 2: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
TCTGTAATGCGTGGAAGAGGCATCACATAGAACTGTTCCCATCTTGAAAGGCGGATGCGCTTGGGTCGTTTCTGTACAACTCTGTCAAGTTTCCCAGGCATTTCATACTGATCACGTATCTTTTTATACCACTTCATGTCAGACATGGGCACGAACTGCTTGATGCGTTGGTCTTCTTCTATGGTAGTCTGCTTATACTTGCGTGGCTCTGGTACATCATAAGGCATCCGGAGTTTTCTCTCCTCCTTCTTTTCTTCTATCTCAAGTCTGAATTCCCCTTTTACAGTCTTGGTGCTTACAGCCGGTTTATAAAGGACAGC...
TCTGTAATGCGTGGAAGAGGCATCACATAGAACTGTTCCCATCTTGAAAGGCGGATGCGCTTGGGTCGTTTCTGTACAACTCTGTCAAGTTTCCCAGGCATTTCATACTGATCACGTATCTTTTTATACCACTTCATGTCAGACATGGGCACGAACTGCTTGATGCGTTGGTCTTCTTCTATGGTAGTCTGCTTATACTTGCGTGGCTCTGGTACATCATAAGGCATCCGGAGTTTTCTCTCCTCCTTCTTTTCTTCTATCTCAAGTCTGAATTCCCCTTTTACAGTCTTGGTGCTTACAGCCGGTTTATAAAGGACAGC...
pathogenic
47,356
Variant on chromosome 2, at position 178535516, affecting TTN: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CAAAGCAGACACTTTGGCCTTCTTGGCATTCTGCATTTGCCAGTAACCTTTTGAACATGGGTCTTAAGGTACTATCTGTTGGAGGTGGGTGTAGGGTTACTGTCAGCTTTGCTTTACAGCTGTCTTCACCATATTTGTTCCTTGCCACAACAGTATATTCAGCGTCATCATCTGTAGTGACACTGTTGATTGTTAATTGGTAAAGACCCTTGTCTGACTCAAATGTGTACTTCTTGTCATTGTCACCTGGTTTGATTTTCTGACCTGATTTATACCATGTTACATGAGGCTCTGGGTGGACAGTTATAGTTACTCCAAAC...
CAAAGCAGACACTTTGGCCTTCTTGGCATTCTGCATTTGCCAGTAACCTTTTGAACATGGGTCTTAAGGTACTATCTGTTGGAGGTGGGTGTAGGGTTACTGTCAGCTTTGCTTTACAGCTGTCTTCACCATATTTGTTCCTTGCCACAACAGTATATTCAGCGTCATCATCTGTAGTGACACTGTTGATTGTTAATTGGTAAAGACCCTTGTCTGACTCAAATGTGTACTTCTTGTCATTGTCACCTGGTTTGATTTTCTGACCTGATTTATACCATGTTACATGAGGCTCTGGGTGGACAGTTATAGTTACTCCAAAC...
pathogenic
47,392
Regarding the variant found on chromosome 2 at position 178535517 in gene TTN: is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AAAGCAGACACTTTGGCCTTCTTGGCATTCTGCATTTGCCAGTAACCTTTTGAACATGGGTCTTAAGGTACTATCTGTTGGAGGTGGGTGTAGGGTTACTGTCAGCTTTGCTTTACAGCTGTCTTCACCATATTTGTTCCTTGCCACAACAGTATATTCAGCGTCATCATCTGTAGTGACACTGTTGATTGTTAATTGGTAAAGACCCTTGTCTGACTCAAATGTGTACTTCTTGTCATTGTCACCTGGTTTGATTTTCTGACCTGATTTATACCATGTTACATGAGGCTCTGGGTGGACAGTTATAGTTACTCCAAACC...
AAAGCAGACACTTTGGCCTTCTTGGCATTCTGCATTTGCCAGTAACCTTTTGAACATGGGTCTTAAGGTACTATCTGTTGGAGGTGGGTGTAGGGTTACTGTCAGCTTTGCTTTACAGCTGTCTTCACCATATTTGTTCCTTGCCACAACAGTATATTCAGCGTCATCATCTGTAGTGACACTGTTGATTGTTAATTGGTAAAGACCCTTGTCTGACTCAAATGTGTACTTCTTGTCATTGTCACCTGGTTTGATTTTCTGACCTGATTTATACCATGTTACATGAGGCTCTGGGTGGACAGTTATAGTTACTCCAAACC...
pathogenic
47,393
Does the genetic variant at chromosome 2, position 178535823, impacting gene TTN, appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
AGTTACTCCAAACCGGACATTTTCACCTACATAAGCTGTCTTATTATAGAGAGGCAGGGTAAATTCTGGTGGCCTTTCCAGGAGTCTCATTGTGTCTGTTCTGCGCTTAATTTTCTTCATGGTTCTACGGCAGTAATAGTCATAGACTTCTCTCACACCTTTAACAAATAGCTCTGCATAAGAACTGTCTTCACCATAGTCATTGACTACTTTGCATCTGTAGGTACCATCATCTAATTTGGTAATGTCTTTGACATAGAGGATGGCCACTCCATCTTCGTAGGTGATTTCGTATTTCTCACTGTTCTCCAGCTGTCGGA...
AGTTACTCCAAACCGGACATTTTCACCTACATAAGCTGTCTTATTATAGAGAGGCAGGGTAAATTCTGGTGGCCTTTCCAGGAGTCTCATTGTGTCTGTTCTGCGCTTAATTTTCTTCATGGTTCTACGGCAGTAATAGTCATAGACTTCTCTCACACCTTTAACAAATAGCTCTGCATAAGAACTGTCTTCACCATAGTCATTGACTACTTTGCATCTGTAGGTACCATCATCTAATTTGGTAATGTCTTTGACATAGAGGATGGCCACTCCATCTTCGTAGGTGATTTCGTATTTCTCACTGTTCTCCAGCTGTCGGA...
pathogenic
47,402
A genetic alteration at chromosome 2, position 178535858, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
benign
CTGTCTTATTATAGAGAGGCAGGGTAAATTCTGGTGGCCTTTCCAGGAGTCTCATTGTGTCTGTTCTGCGCTTAATTTTCTTCATGGTTCTACGGCAGTAATAGTCATAGACTTCTCTCACACCTTTAACAAATAGCTCTGCATAAGAACTGTCTTCACCATAGTCATTGACTACTTTGCATCTGTAGGTACCATCATCTAATTTGGTAATGTCTTTGACATAGAGGATGGCCACTCCATCTTCGTAGGTGATTTCGTATTTCTCACTGTTCTCCAGCTGTCGGACGCCAAAGTACCAAGTCACTTGGGTAGACTGATCA...
CTGTCTTATTATAGAGAGGCAGGGTAAATTCTGGTGGCCTTTCCAGGAGTCTCATTGTGTCTGTTCTGCGCTTAATTTTCTTCATGGTTCTACGGCAGTAATAGTCATAGACTTCTCTCACACCTTTAACAAATAGCTCTGCATAAGAACTGTCTTCACCATAGTCATTGACTACTTTGCATCTGTAGGTACCATCATCTAATTTGGTAATGTCTTTGACATAGAGGATGGCCACTCCATCTTCGTAGGTGATTTCGTATTTCTCACTGTTCTCCAGCTGTCGGACGCCAAAGTACCAAGTCACTTGGGTAGACTGATCA...
benign
47,407
Is the genetic change at chromosome 2, position 178535858, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
benign
CTGTCTTATTATAGAGAGGCAGGGTAAATTCTGGTGGCCTTTCCAGGAGTCTCATTGTGTCTGTTCTGCGCTTAATTTTCTTCATGGTTCTACGGCAGTAATAGTCATAGACTTCTCTCACACCTTTAACAAATAGCTCTGCATAAGAACTGTCTTCACCATAGTCATTGACTACTTTGCATCTGTAGGTACCATCATCTAATTTGGTAATGTCTTTGACATAGAGGATGGCCACTCCATCTTCGTAGGTGATTTCGTATTTCTCACTGTTCTCCAGCTGTCGGACGCCAAAGTACCAAGTCACTTGGGTAGACTGATCA...
CTGTCTTATTATAGAGAGGCAGGGTAAATTCTGGTGGCCTTTCCAGGAGTCTCATTGTGTCTGTTCTGCGCTTAATTTTCTTCATGGTTCTACGGCAGTAATAGTCATAGACTTCTCTCACACCTTTAACAAATAGCTCTGCATAAGAACTGTCTTCACCATAGTCATTGACTACTTTGCATCTGTAGGTACCATCATCTAATTTGGTAATGTCTTTGACATAGAGGATGGCCACTCCATCTTCGTAGGTGATTTCGTATTTCTCACTGTTCTCCAGCTGTCGGACGCCAAAGTACCAAGTCACTTGGGTAGACTGATCA...
benign
47,408
Does the genetic variant at chromosome 2, position 178536300, impacting gene TTN, appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTTCTGAGATCGAATTGCACCACCACAGGAGATCCGGGCTGCTGACACAACCATGTTGAGGTCTTTCTTGATCAGGGTGTGGTAATAACGCCGGTGTTTTAATGTTCTGATAACTTTAGTACTGACTCTTTCTATCTTCTGCTTCAACCATGGGTGCTGGAGAGCCTCCGATGCTGTCATGCGAGATTTCCTCTCTTTCACTAACAACCGGTCAACAAAATCCATGGCTTCAATGCTAATCTCTTTGAATGCTTCCTCATCGAAAGTATATTCAGCATTCATGATATTCTCAATGATCTGTTGGTTAGTTTCAGCCAGGA...
CTTCTGAGATCGAATTGCACCACCACAGGAGATCCGGGCTGCTGACACAACCATGTTGAGGTCTTTCTTGATCAGGGTGTGGTAATAACGCCGGTGTTTTAATGTTCTGATAACTTTAGTACTGACTCTTTCTATCTTCTGCTTCAACCATGGGTGCTGGAGAGCCTCCGATGCTGTCATGCGAGATTTCCTCTCTTTCACTAACAACCGGTCAACAAAATCCATGGCTTCAATGCTAATCTCTTTGAATGCTTCCTCATCGAAAGTATATTCAGCATTCATGATATTCTCAATGATCTGTTGGTTAGTTTCAGCCAGGA...
pathogenic
47,420
Does the variant on chromosome 2 at location 178536584 affecting gene TTN have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
benign
TATTCTCAATGATCTGTTGGTTAGTTTCAGCCAGGAATGGGTTGATACCACTCAATAGCACATATACCAGTGTTCCAAGTGACCACATGTCTGTGGCTGTGCTGACAACATCATGCTGGTGGACTTCAGGTGCATAGTATTCTGGGGCAGTGAATAGAAGCCTGAAGTTGTCCCCTGGTTTCAGCTGACGGGCTTGACCAAATTCTATGATTTTAATGGTAGAGCTTCTTCTGGTTTGGTAAATGATATTTTCTGGTCTAATGTCAAAGTGTCCAATATTATGACTGTGTAAAAACTGAAGTGCTTCACAGACCTGGTGA...
TATTCTCAATGATCTGTTGGTTAGTTTCAGCCAGGAATGGGTTGATACCACTCAATAGCACATATACCAGTGTTCCAAGTGACCACATGTCTGTGGCTGTGCTGACAACATCATGCTGGTGGACTTCAGGTGCATAGTATTCTGGGGCAGTGAATAGAAGCCTGAAGTTGTCCCCTGGTTTCAGCTGACGGGCTTGACCAAATTCTATGATTTTAATGGTAGAGCTTCTTCTGGTTTGGTAAATGATATTTTCTGGTCTAATGTCAAAGTGTCCAATATTATGACTGTGTAAAAACTGAAGTGCTTCACAGACCTGGTGA...
benign
47,432
Variant at chromosome 2, position 178536921, gene TTN: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
benign
TCTTTCATTAAGTTCAAAAGCACTTGTGTTAATGCGCTCAAATATGTCAAGTCCTGATATAAACTCAAAGATCATAACTAATTCTTCCATGCTTTCAAATGATTCATGGAGGTGTAAGATGTTTCTATGCCTAGCAATATTCAGAATGGAAATTTCCTTCTTTACCAAAACCTGATCAGTCCCTTTGACTTTAACAAATTTGGCCATGTATGTCTTCTTTGAGGATGTTTCAACACAACGATGGACAATTCCAAACTCACCACGCCCAAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAG...
TCTTTCATTAAGTTCAAAAGCACTTGTGTTAATGCGCTCAAATATGTCAAGTCCTGATATAAACTCAAAGATCATAACTAATTCTTCCATGCTTTCAAATGATTCATGGAGGTGTAAGATGTTTCTATGCCTAGCAATATTCAGAATGGAAATTTCCTTCTTTACCAAAACCTGATCAGTCCCTTTGACTTTAACAAATTTGGCCATGTATGTCTTCTTTGAGGATGTTTCAACACAACGATGGACAATTCCAAACTCACCACGCCCAAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAG...
benign
47,434
Clinical significance of chromosome 2, position 178536947, gene TTN: benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TGTTAATGCGCTCAAATATGTCAAGTCCTGATATAAACTCAAAGATCATAACTAATTCTTCCATGCTTTCAAATGATTCATGGAGGTGTAAGATGTTTCTATGCCTAGCAATATTCAGAATGGAAATTTCCTTCTTTACCAAAACCTGATCAGTCCCTTTGACTTTAACAAATTTGGCCATGTATGTCTTCTTTGAGGATGTTTCAACACAACGATGGACAATTCCAAACTCACCACGCCCAAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAGATGCTTTAGTCATGGAGACTTCCCTG...
TGTTAATGCGCTCAAATATGTCAAGTCCTGATATAAACTCAAAGATCATAACTAATTCTTCCATGCTTTCAAATGATTCATGGAGGTGTAAGATGTTTCTATGCCTAGCAATATTCAGAATGGAAATTTCCTTCTTTACCAAAACCTGATCAGTCCCTTTGACTTTAACAAATTTGGCCATGTATGTCTTCTTTGAGGATGTTTCAACACAACGATGGACAATTCCAAACTCACCACGCCCAAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAGATGCTTTAGTCATGGAGACTTCCCTG...
pathogenic
47,435
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 2, position 178536957, gene TTN. What disease(s) is it linked to if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CTCAAATATGTCAAGTCCTGATATAAACTCAAAGATCATAACTAATTCTTCCATGCTTTCAAATGATTCATGGAGGTGTAAGATGTTTCTATGCCTAGCAATATTCAGAATGGAAATTTCCTTCTTTACCAAAACCTGATCAGTCCCTTTGACTTTAACAAATTTGGCCATGTATGTCTTCTTTGAGGATGTTTCAACACAACGATGGACAATTCCAAACTCACCACGCCCAAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAGATGCTTTAGTCATGGAGACTTCCCTGGTTTCATCTA...
CTCAAATATGTCAAGTCCTGATATAAACTCAAAGATCATAACTAATTCTTCCATGCTTTCAAATGATTCATGGAGGTGTAAGATGTTTCTATGCCTAGCAATATTCAGAATGGAAATTTCCTTCTTTACCAAAACCTGATCAGTCCCTTTGACTTTAACAAATTTGGCCATGTATGTCTTCTTTGAGGATGTTTCAACACAACGATGGACAATTCCAAACTCACCACGCCCAAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAGATGCTTTAGTCATGGAGACTTCCCTGGTTTCATCTA...
pathogenic
47,436
Located at chromosome 2 position 178537078, the variant affecting gene TTN—benign or pathogenic? If pathogenic, which disease(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
TTCTTTACCAAAACCTGATCAGTCCCTTTGACTTTAACAAATTTGGCCATGTATGTCTTCTTTGAGGATGTTTCAACACAACGATGGACAATTCCAAACTCACCACGCCCAAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAGATGCTTTAGTCATGGAGACTTCCCTGGTTTCATCTACCTCTTCATCATAGTTCATAGCTCTGGTCTTATCTTCTTTGGTTATGGTTGGTTCTGAAGGCTCTGAAGGCTTGCTCAGACCAAATTTATTTTCAGCTATTACCCGGAACTGGTAACTTGT...
TTCTTTACCAAAACCTGATCAGTCCCTTTGACTTTAACAAATTTGGCCATGTATGTCTTCTTTGAGGATGTTTCAACACAACGATGGACAATTCCAAACTCACCACGCCCAAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAGATGCTTTAGTCATGGAGACTTCCCTGGTTTCATCTACCTCTTCATCATAGTTCATAGCTCTGGTCTTATCTTCTTTGGTTATGGTTGGTTCTGAAGGCTCTGAAGGCTTGCTCAGACCAAATTTATTTTCAGCTATTACCCGGAACTGGTAACTTGT...
pathogenic
47,441
Variant on chromosome 2, at position 178537188, affecting TTN: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic
AAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAGATGCTTTAGTCATGGAGACTTCCCTGGTTTCATCTACCTCTTCATCATAGTTCATAGCTCTGGTCTTATCTTCTTTGGTTATGGTTGGTTCTGAAGGCTCTGAAGGCTTGCTCAGACCAAATTTATTTTCAGCTATTACCCGGAACTGGTAACTTGTTTTTCCAAATAAGTTGATCACGGTATAACGTGTTTCTCGGGCCTGTCCTACACGGAGCCATCTTTCTGCAGTAGTTGCACATTTTTCAACAATGTAGTTGGTGATTTTGC...
AAGATCTTCAGCAATCATATATTTCTCATAGAGTTCCTTGGTTGAAGAGTGAGATGCTTTAGTCATGGAGACTTCCCTGGTTTCATCTACCTCTTCATCATAGTTCATAGCTCTGGTCTTATCTTCTTTGGTTATGGTTGGTTCTGAAGGCTCTGAAGGCTTGCTCAGACCAAATTTATTTTCAGCTATTACCCGGAACTGGTAACTTGTTTTTCCAAATAAGTTGATCACGGTATAACGTGTTTCTCGGGCCTGTCCTACACGGAGCCATCTTTCTGCAGTAGTTGCACATTTTTCAACAATGTAGTTGGTGATTTTGC...
pathogenic
47,451
Evaluate if the mutation on chromosome 2 at position 178537234 in TTN is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_familial_dilated_cardiomyopathy']
GAGTGAGATGCTTTAGTCATGGAGACTTCCCTGGTTTCATCTACCTCTTCATCATAGTTCATAGCTCTGGTCTTATCTTCTTTGGTTATGGTTGGTTCTGAAGGCTCTGAAGGCTTGCTCAGACCAAATTTATTTTCAGCTATTACCCGGAACTGGTAACTTGTTTTTCCAAATAAGTTGATCACGGTATAACGTGTTTCTCGGGCCTGTCCTACACGGAGCCATCTTTCTGCAGTAGTTGCACATTTTTCAACAATGTAGTTGGTGATTTTGCTGCCACCATCAGAGGCTGGCTCAGTCCATGTTAAGTTGACAGAATC...
GAGTGAGATGCTTTAGTCATGGAGACTTCCCTGGTTTCATCTACCTCTTCATCATAGTTCATAGCTCTGGTCTTATCTTCTTTGGTTATGGTTGGTTCTGAAGGCTCTGAAGGCTTGCTCAGACCAAATTTATTTTCAGCTATTACCCGGAACTGGTAACTTGTTTTTCCAAATAAGTTGATCACGGTATAACGTGTTTCTCGGGCCTGTCCTACACGGAGCCATCTTTCTGCAGTAGTTGCACATTTTTCAACAATGTAGTTGGTGATTTTGCTGCCACCATCAGAGGCTGGCTCAGTCCATGTTAAGTTGACAGAATC...
pathogenic
47,453
Variant chromosome 2, position 178538643, gene TTN: benign or pathogenic? Disease(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TTTGAGTCATGAGATGAAACAGGCAGCTTTATTAAAGCTTATTTTTTTAAAAAAGAATGTTATATGAGTCCAAAATTTTGTTAAAAAATAGCTATTCCAGAAAGATGAAATTGGTTACTTTATACTAAGACATATCAAAAACCAAAGTTCTATTTTTACAATGGGGTTAGGATATATATTTCTCCTTTTAGATATGCAAACATTCAATTAAAGTGAAAGAAAAGGCACTTGTACTTTATCTGAATCTTTGCTATTTCCTTTCAAAATTTCTTTCTGTTTAAAAGAATTTTATGCAAAGATGGAACTTTACCATAGGAAGA...
TTTGAGTCATGAGATGAAACAGGCAGCTTTATTAAAGCTTATTTTTTTAAAAAAGAATGTTATATGAGTCCAAAATTTTGTTAAAAAATAGCTATTCCAGAAAGATGAAATTGGTTACTTTATACTAAGACATATCAAAAACCAAAGTTCTATTTTTACAATGGGGTTAGGATATATATTTCTCCTTTTAGATATGCAAACATTCAATTAAAGTGAAAGAAAAGGCACTTGTACTTTATCTGAATCTTTGCTATTTCCTTTCAAAATTTCTTTCTGTTTAAAAGAATTTTATGCAAAGATGGAACTTTACCATAGGAAGA...
pathogenic
47,481
Is the genetic change at chromosome 2, position 178538765, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
TACTAAGACATATCAAAAACCAAAGTTCTATTTTTACAATGGGGTTAGGATATATATTTCTCCTTTTAGATATGCAAACATTCAATTAAAGTGAAAGAAAAGGCACTTGTACTTTATCTGAATCTTTGCTATTTCCTTTCAAAATTTCTTTCTGTTTAAAAGAATTTTATGCAAAGATGGAACTTTACCATAGGAAGATACAGAAATCAAGTTGTACTCACCAAATGGACTCTTAATGATCACAACTGAGGACACTTCTAGAGGGTCACTGATGCCGAAAGTGTTCTGAGCTGAAACCCGGAAGTAATAGCCAGCATTTT...
TACTAAGACATATCAAAAACCAAAGTTCTATTTTTACAATGGGGTTAGGATATATATTTCTCCTTTTAGATATGCAAACATTCAATTAAAGTGAAAGAAAAGGCACTTGTACTTTATCTGAATCTTTGCTATTTCCTTTCAAAATTTCTTTCTGTTTAAAAGAATTTTATGCAAAGATGGAACTTTACCATAGGAAGATACAGAAATCAAGTTGTACTCACCAAATGGACTCTTAATGATCACAACTGAGGACACTTCTAGAGGGTCACTGATGCCGAAAGTGTTCTGAGCTGAAACCCGGAAGTAATAGCCAGCATTTT...
pathogenic
47,487
Gene TTN variant at chromosome 2, position 178538787—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AAGTTCTATTTTTACAATGGGGTTAGGATATATATTTCTCCTTTTAGATATGCAAACATTCAATTAAAGTGAAAGAAAAGGCACTTGTACTTTATCTGAATCTTTGCTATTTCCTTTCAAAATTTCTTTCTGTTTAAAAGAATTTTATGCAAAGATGGAACTTTACCATAGGAAGATACAGAAATCAAGTTGTACTCACCAAATGGACTCTTAATGATCACAACTGAGGACACTTCTAGAGGGTCACTGATGCCGAAAGTGTTCTGAGCTGAAACCCGGAAGTAATAGCCAGCATTTTCTGTGAGGTTCACAATTCTACA...
AAGTTCTATTTTTACAATGGGGTTAGGATATATATTTCTCCTTTTAGATATGCAAACATTCAATTAAAGTGAAAGAAAAGGCACTTGTACTTTATCTGAATCTTTGCTATTTCCTTTCAAAATTTCTTTCTGTTTAAAAGAATTTTATGCAAAGATGGAACTTTACCATAGGAAGATACAGAAATCAAGTTGTACTCACCAAATGGACTCTTAATGATCACAACTGAGGACACTTCTAGAGGGTCACTGATGCCGAAAGTGTTCTGAGCTGAAACCCGGAAGTAATAGCCAGCATTTTCTGTGAGGTTCACAATTCTACA...
pathogenic
47,489
Does the genetic variant at chromosome 2, position 178538834, impacting gene TTN, appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Autosomal_recessive_titinopathy', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy', 'Primary_familial_dilated_cardiomyopathy', 'TTN-related_disorder']
ATATGCAAACATTCAATTAAAGTGAAAGAAAAGGCACTTGTACTTTATCTGAATCTTTGCTATTTCCTTTCAAAATTTCTTTCTGTTTAAAAGAATTTTATGCAAAGATGGAACTTTACCATAGGAAGATACAGAAATCAAGTTGTACTCACCAAATGGACTCTTAATGATCACAACTGAGGACACTTCTAGAGGGTCACTGATGCCGAAAGTGTTCTGAGCTGAAACCCGGAAGTAATAGCCAGCATTTTCTGTGAGGTTCACAATTCTACAGGTTGTCACTGAGATGGCTGAAGACACCAATTGCCATTCAGCCCCCT...
ATATGCAAACATTCAATTAAAGTGAAAGAAAAGGCACTTGTACTTTATCTGAATCTTTGCTATTTCCTTTCAAAATTTCTTTCTGTTTAAAAGAATTTTATGCAAAGATGGAACTTTACCATAGGAAGATACAGAAATCAAGTTGTACTCACCAAATGGACTCTTAATGATCACAACTGAGGACACTTCTAGAGGGTCACTGATGCCGAAAGTGTTCTGAGCTGAAACCCGGAAGTAATAGCCAGCATTTTCTGTGAGGTTCACAATTCTACAGGTTGTCACTGAGATGGCTGAAGACACCAATTGCCATTCAGCCCCCT...
pathogenic
47,492
Variant chromosome 2, position 178539123, gene TTN: benign or pathogenic? Disease(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Hypertrophic_cardiomyopathy_9']
GCTGAAGACACCAATTGCCATTCAGCCCCCTCCTTGGCCTCACATTTTTCCACCACATAGTTGGTGATCCAGGAGCCTCCGTCATCTGCGGGTGGTTTCCAGCTGATCACTGCGGAGTTCTTCAATAGAGCTTCGATCACAATTGGTCCTGTAGGTTTGTCTGGTTTATCTGTTGGGGGAAAATACAATTGTGGTGGTTTTCATAGTGTGTTTTTGAGATTTTTTTTTCTTTAAAAATAAAAAGCACTGAAAATAAAAATAAAATACCTTGTATTTCCACATCAAGGATGGCATCAACTGTTCCAAAAACATTGCTGAGC...
GCTGAAGACACCAATTGCCATTCAGCCCCCTCCTTGGCCTCACATTTTTCCACCACATAGTTGGTGATCCAGGAGCCTCCGTCATCTGCGGGTGGTTTCCAGCTGATCACTGCGGAGTTCTTCAATAGAGCTTCGATCACAATTGGTCCTGTAGGTTTGTCTGGTTTATCTGTTGGGGGAAAATACAATTGTGGTGGTTTTCATAGTGTGTTTTTGAGATTTTTTTTTCTTTAAAAATAAAAAGCACTGAAAATAAAAATAAAATACCTTGTATTTCCACATCAAGGATGGCATCAACTGTTCCAAAAACATTGCTGAGC...
pathogenic
47,502
Mutation at chromosome 2, position 178539764, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Primary_dilated_cardiomyopathy', 'SUDDEN_INFANT_DEATH_SYNDROME']
TCCTCTGTCATTACTGTAAGAGTGTGTGTGCGTCCATCTGAAGACATTTTGTATTTCCGGCTTTGTATGAGCTCTTTACCAAATCTGTACCATTTAATGTCAGGAAGAGGCCTTCCAACAATCTGGCATGAGAGTTGAGCAGCTTCACCCAATTTTGTGGTAACATCCTTCATTTCTTTGCGTATTCCTGGGGCCTCTCCAGCTGAACAATATGAAAGATAATATTAAGTGACTGTTAATACTCAATCTGTAATCCTTTGTCCTTGTATATCAGGAATGAATTTACCTTATTTACTGACACATACCATGATTTACATATT...
TCCTCTGTCATTACTGTAAGAGTGTGTGTGCGTCCATCTGAAGACATTTTGTATTTCCGGCTTTGTATGAGCTCTTTACCAAATCTGTACCATTTAATGTCAGGAAGAGGCCTTCCAACAATCTGGCATGAGAGTTGAGCAGCTTCACCCAATTTTGTGGTAACATCCTTCATTTCTTTGCGTATTCCTGGGGCCTCTCCAGCTGAACAATATGAAAGATAATATTAAGTGACTGTTAATACTCAATCTGTAATCCTTTGTCCTTGTATATCAGGAATGAATTTACCTTATTTACTGACACATACCATGATTTACATATT...
pathogenic
47,523
Variant in gene TTN, located at chromosome 2 position 178539765: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CCTCTGTCATTACTGTAAGAGTGTGTGTGCGTCCATCTGAAGACATTTTGTATTTCCGGCTTTGTATGAGCTCTTTACCAAATCTGTACCATTTAATGTCAGGAAGAGGCCTTCCAACAATCTGGCATGAGAGTTGAGCAGCTTCACCCAATTTTGTGGTAACATCCTTCATTTCTTTGCGTATTCCTGGGGCCTCTCCAGCTGAACAATATGAAAGATAATATTAAGTGACTGTTAATACTCAATCTGTAATCCTTTGTCCTTGTATATCAGGAATGAATTTACCTTATTTACTGACACATACCATGATTTACATATTA...
CCTCTGTCATTACTGTAAGAGTGTGTGTGCGTCCATCTGAAGACATTTTGTATTTCCGGCTTTGTATGAGCTCTTTACCAAATCTGTACCATTTAATGTCAGGAAGAGGCCTTCCAACAATCTGGCATGAGAGTTGAGCAGCTTCACCCAATTTTGTGGTAACATCCTTCATTTCTTTGCGTATTCCTGGGGCCTCTCCAGCTGAACAATATGAAAGATAATATTAAGTGACTGTTAATACTCAATCTGTAATCCTTTGTCCTTGTATATCAGGAATGAATTTACCTTATTTACTGACACATACCATGATTTACATATTA...
pathogenic
47,524
A mutation at chromosome position 178540085 on chromosome 2 in gene TTN: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
GCCTAATTCTTAAAAACTCTTTGAAGTGATTTTCCTAGGATCATATGGTAAATAGGGATTCAATGAGCACATCGTCACATTTTATGTAGAGTGTTTTTTTCTCTTTATGATTGGAAGGGGATTAATAATGTATAGGCTTTTAAGGGACTGTAAATTCTCTCTATAATTCTGTAGTATTCTTGCCCTTACTTAGGTTCATTGAAGTGGCATACAATTGTTGACCTTTCAAATCTTGTTGGGAAATATTTTTAAAAAGAAACCATTGCATTAGAGGGAATTACTCAAGGAAAGTGCTCAGTTCACTCCATCTAACATCTGCT...
GCCTAATTCTTAAAAACTCTTTGAAGTGATTTTCCTAGGATCATATGGTAAATAGGGATTCAATGAGCACATCGTCACATTTTATGTAGAGTGTTTTTTTCTCTTTATGATTGGAAGGGGATTAATAATGTATAGGCTTTTAAGGGACTGTAAATTCTCTCTATAATTCTGTAGTATTCTTGCCCTTACTTAGGTTCATTGAAGTGGCATACAATTGTTGACCTTTCAAATCTTGTTGGGAAATATTTTTAAAAAGAAACCATTGCATTAGAGGGAATTACTCAAGGAAAGTGCTCAGTTCACTCCATCTAACATCTGCT...
pathogenic
47,540
Mutation at chromosome 2, position 178540093, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CTTAAAAACTCTTTGAAGTGATTTTCCTAGGATCATATGGTAAATAGGGATTCAATGAGCACATCGTCACATTTTATGTAGAGTGTTTTTTTCTCTTTATGATTGGAAGGGGATTAATAATGTATAGGCTTTTAAGGGACTGTAAATTCTCTCTATAATTCTGTAGTATTCTTGCCCTTACTTAGGTTCATTGAAGTGGCATACAATTGTTGACCTTTCAAATCTTGTTGGGAAATATTTTTAAAAAGAAACCATTGCATTAGAGGGAATTACTCAAGGAAAGTGCTCAGTTCACTCCATCTAACATCTGCTGAGGTTGT...
CTTAAAAACTCTTTGAAGTGATTTTCCTAGGATCATATGGTAAATAGGGATTCAATGAGCACATCGTCACATTTTATGTAGAGTGTTTTTTTCTCTTTATGATTGGAAGGGGATTAATAATGTATAGGCTTTTAAGGGACTGTAAATTCTCTCTATAATTCTGTAGTATTCTTGCCCTTACTTAGGTTCATTGAAGTGGCATACAATTGTTGACCTTTCAAATCTTGTTGGGAAATATTTTTAAAAAGAAACCATTGCATTAGAGGGAATTACTCAAGGAAAGTGCTCAGTTCACTCCATCTAACATCTGCTGAGGTTGT...
pathogenic
47,542
Variant in TTN, chromosome 2, position 178540215—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TATAGGCTTTTAAGGGACTGTAAATTCTCTCTATAATTCTGTAGTATTCTTGCCCTTACTTAGGTTCATTGAAGTGGCATACAATTGTTGACCTTTCAAATCTTGTTGGGAAATATTTTTAAAAAGAAACCATTGCATTAGAGGGAATTACTCAAGGAAAGTGCTCAGTTCACTCCATCTAACATCTGCTGAGGTTGTGTGCTTGGAATGGTTTCCTGTAGAACTTGTCATATTTCCTGTGTGTGTACTTGCTTTTCTTTCTTAACACTTGCTCTCCAATAAAGCTTTCCAGGGTTCTACTTAGTATAGAGGGGGAATTA...
TATAGGCTTTTAAGGGACTGTAAATTCTCTCTATAATTCTGTAGTATTCTTGCCCTTACTTAGGTTCATTGAAGTGGCATACAATTGTTGACCTTTCAAATCTTGTTGGGAAATATTTTTAAAAAGAAACCATTGCATTAGAGGGAATTACTCAAGGAAAGTGCTCAGTTCACTCCATCTAACATCTGCTGAGGTTGTGTGCTTGGAATGGTTTCCTGTAGAACTTGTCATATTTCCTGTGTGTGTACTTGCTTTTCTTTCTTAACACTTGCTCTCCAATAAAGCTTTCCAGGGTTCTACTTAGTATAGAGGGGGAATTA...
pathogenic
47,550
Does the variant impacting TTN on chromosome 2, position 178541413, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
GTTGAAAGGGCACTTACTCAATGGTGTTTTTGGTGTGACTGGTTCCTCAGATTTCAAGGGTTTGCTTATGCCAAACTGGTTTTCTGCTGAAACACGGAAATGGTATTCTACATTCTCTTTGAGGCCTTTTACCACCAGAGATGTACCTCGGACTCTGGAATCAATGGTATACCAGGCGGCTTTAGGCACTTCTCGTCTCTCGAGGATGTAGCCTAAGATGTCAGCACCACCATCATCAGCAGGAGGTCTCCAGCTGACCCTCACAGAGCGGACTTGGATGTCATCATATTCCAGTGGCCCTTCTGGACTGTTGGGACTTC...
GTTGAAAGGGCACTTACTCAATGGTGTTTTTGGTGTGACTGGTTCCTCAGATTTCAAGGGTTTGCTTATGCCAAACTGGTTTTCTGCTGAAACACGGAAATGGTATTCTACATTCTCTTTGAGGCCTTTTACCACCAGAGATGTACCTCGGACTCTGGAATCAATGGTATACCAGGCGGCTTTAGGCACTTCTCGTCTCTCGAGGATGTAGCCTAAGATGTCAGCACCACCATCATCAGCAGGAGGTCTCCAGCTGACCCTCACAGAGCGGACTTGGATGTCATCATATTCCAGTGGCCCTTCTGGACTGTTGGGACTTC...
pathogenic
47,567
Clinical classification of chromosome 2, position 178541488, gene TTN: benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTGGTTTTCTGCTGAAACACGGAAATGGTATTCTACATTCTCTTTGAGGCCTTTTACCACCAGAGATGTACCTCGGACTCTGGAATCAATGGTATACCAGGCGGCTTTAGGCACTTCTCGTCTCTCGAGGATGTAGCCTAAGATGTCAGCACCACCATCATCAGCAGGAGGTCTCCAGCTGACCCTCACAGAGCGGACTTGGATGTCATCATATTCCAGTGGCCCTTCTGGACTGTTGGGACTTCCTATCACCCTGACCTTGATGTAGACAGCCTTCTTGCCACATTTATTTTCCAGAACCAGGTCATAAGTGCCAGAAT...
CTGGTTTTCTGCTGAAACACGGAAATGGTATTCTACATTCTCTTTGAGGCCTTTTACCACCAGAGATGTACCTCGGACTCTGGAATCAATGGTATACCAGGCGGCTTTAGGCACTTCTCGTCTCTCGAGGATGTAGCCTAAGATGTCAGCACCACCATCATCAGCAGGAGGTCTCCAGCTGACCCTCACAGAGCGGACTTGGATGTCATCATATTCCAGTGGCCCTTCTGGACTGTTGGGACTTCCTATCACCCTGACCTTGATGTAGACAGCCTTCTTGCCACATTTATTTTCCAGAACCAGGTCATAAGTGCCAGAAT...
pathogenic
47,575
The chromosome 2, position 178541518 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Cardiovascular_phenotype']
TTCTACATTCTCTTTGAGGCCTTTTACCACCAGAGATGTACCTCGGACTCTGGAATCAATGGTATACCAGGCGGCTTTAGGCACTTCTCGTCTCTCGAGGATGTAGCCTAAGATGTCAGCACCACCATCATCAGCAGGAGGTCTCCAGCTGACCCTCACAGAGCGGACTTGGATGTCATCATATTCCAGTGGCCCTTCTGGACTGTTGGGACTTCCTATCACCCTGACCTTGATGTAGACAGCCTTCTTGCCACATTTATTTTCCAGAACCAGGTCATAAGTGCCAGAATCACCCCTGTCTGCTTCTTTGATCACAAGCT...
TTCTACATTCTCTTTGAGGCCTTTTACCACCAGAGATGTACCTCGGACTCTGGAATCAATGGTATACCAGGCGGCTTTAGGCACTTCTCGTCTCTCGAGGATGTAGCCTAAGATGTCAGCACCACCATCATCAGCAGGAGGTCTCCAGCTGACCCTCACAGAGCGGACTTGGATGTCATCATATTCCAGTGGCCCTTCTGGACTGTTGGGACTTCCTATCACCCTGACCTTGATGTAGACAGCCTTCTTGCCACATTTATTTTCCAGAACCAGGTCATAAGTGCCAGAATCACCCCTGTCTGCTTCTTTGATCACAAGCT...
pathogenic
47,579
Does the chromosome 2 mutation at position 178541549 within gene TTN classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AGAGATGTACCTCGGACTCTGGAATCAATGGTATACCAGGCGGCTTTAGGCACTTCTCGTCTCTCGAGGATGTAGCCTAAGATGTCAGCACCACCATCATCAGCAGGAGGTCTCCAGCTGACCCTCACAGAGCGGACTTGGATGTCATCATATTCCAGTGGCCCTTCTGGACTGTTGGGACTTCCTATCACCCTGACCTTGATGTAGACAGCCTTCTTGCCACATTTATTTTCCAGAACCAGGTCATAAGTGCCAGAATCACCCCTGTCTGCTTCTTTGATCACAAGCTCAGTGTGTGTTTCAGATGTTGCAATCATGGC...
AGAGATGTACCTCGGACTCTGGAATCAATGGTATACCAGGCGGCTTTAGGCACTTCTCGTCTCTCGAGGATGTAGCCTAAGATGTCAGCACCACCATCATCAGCAGGAGGTCTCCAGCTGACCCTCACAGAGCGGACTTGGATGTCATCATATTCCAGTGGCCCTTCTGGACTGTTGGGACTTCCTATCACCCTGACCTTGATGTAGACAGCCTTCTTGCCACATTTATTTTCCAGAACCAGGTCATAAGTGCCAGAATCACCCCTGTCTGCTTCTTTGATCACAAGCTCAGTGTGTGTTTCAGATGTTGCAATCATGGC...
pathogenic
47,581
Evaluate this variant at chromosome 2, position 178542282, gene TTN: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TTGATCTACTTTTTGCATTTCAATCAAGTAGCCTGTGACTTTAGATCCTCCTTCATCTTCTGGAACACTCCAGGCCAGGGAGACTGATGTCCTTGTTGTATCAGTAACTCTTGGGTTTTGTGGCTTTCCTGGAGGAGCTGAGAATAAGAATAAGAATATACTGGTTAAAGTTGCTGCAAAGTTGAAAATTAGCTGTGCCACCTAACAAATTCAATGAGTTGTTGAAACGGACTGTTAACATTAGCCTGTTTTTTTGTCTTGTGAAAATTTTATTCATGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCAAGTTGGG...
TTGATCTACTTTTTGCATTTCAATCAAGTAGCCTGTGACTTTAGATCCTCCTTCATCTTCTGGAACACTCCAGGCCAGGGAGACTGATGTCCTTGTTGTATCAGTAACTCTTGGGTTTTGTGGCTTTCCTGGAGGAGCTGAGAATAAGAATAAGAATATACTGGTTAAAGTTGCTGCAAAGTTGAAAATTAGCTGTGCCACCTAACAAATTCAATGAGTTGTTGAAACGGACTGTTAACATTAGCCTGTTTTTTTGTCTTGTGAAAATTTTATTCATGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCAAGTTGGG...
pathogenic
47,585
Variant in TTN, chromosome 2, position 178542303—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
AATCAAGTAGCCTGTGACTTTAGATCCTCCTTCATCTTCTGGAACACTCCAGGCCAGGGAGACTGATGTCCTTGTTGTATCAGTAACTCTTGGGTTTTGTGGCTTTCCTGGAGGAGCTGAGAATAAGAATAAGAATATACTGGTTAAAGTTGCTGCAAAGTTGAAAATTAGCTGTGCCACCTAACAAATTCAATGAGTTGTTGAAACGGACTGTTAACATTAGCCTGTTTTTTTGTCTTGTGAAAATTTTATTCATGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCAAGTTGGGAGGCCAAGGTGGGCAGATACT...
AATCAAGTAGCCTGTGACTTTAGATCCTCCTTCATCTTCTGGAACACTCCAGGCCAGGGAGACTGATGTCCTTGTTGTATCAGTAACTCTTGGGTTTTGTGGCTTTCCTGGAGGAGCTGAGAATAAGAATAAGAATATACTGGTTAAAGTTGCTGCAAAGTTGAAAATTAGCTGTGCCACCTAACAAATTCAATGAGTTGTTGAAACGGACTGTTAACATTAGCCTGTTTTTTTGTCTTGTGAAAATTTTATTCATGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCAAGTTGGGAGGCCAAGGTGGGCAGATACT...
pathogenic
47,587
A genetic alteration at chromosome 2, position 178542338, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Cardiovascular_phenotype', 'Centronuclear_myopathy', 'Dilated_cardiomyopathy_1G']
CTTCTGGAACACTCCAGGCCAGGGAGACTGATGTCCTTGTTGTATCAGTAACTCTTGGGTTTTGTGGCTTTCCTGGAGGAGCTGAGAATAAGAATAAGAATATACTGGTTAAAGTTGCTGCAAAGTTGAAAATTAGCTGTGCCACCTAACAAATTCAATGAGTTGTTGAAACGGACTGTTAACATTAGCCTGTTTTTTTGTCTTGTGAAAATTTTATTCATGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCAAGTTGGGAGGCCAAGGTGGGCAGATACTTGAGGTCAGGAGTTAGTTCAAGACCAGCCTGGCCA...
CTTCTGGAACACTCCAGGCCAGGGAGACTGATGTCCTTGTTGTATCAGTAACTCTTGGGTTTTGTGGCTTTCCTGGAGGAGCTGAGAATAAGAATAAGAATATACTGGTTAAAGTTGCTGCAAAGTTGAAAATTAGCTGTGCCACCTAACAAATTCAATGAGTTGTTGAAACGGACTGTTAACATTAGCCTGTTTTTTTGTCTTGTGAAAATTTTATTCATGGCTGGGTGTGGTGGCTCATGCCTGTAATCACAGCAAGTTGGGAGGCCAAGGTGGGCAGATACTTGAGGTCAGGAGTTAGTTCAAGACCAGCCTGGCCA...
pathogenic
47,589
Classify the chromosome 2 variant at position 178542723 affecting gene TTN as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Primary_dilated_cardiomyopathy', 'Tibial_mu...
AATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATTGCTTGAACCTGGGAGACAGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAACACAAAAAAACAAAAGAAAGAAAAAAGAAAATTTTATTCATTTTATCAGCTAAAAATACTTAACATTTTTTCACTTTCCTTTCTCTTAAATGTGCTTCATTTGTAATCACTATTATTATCTTACATTTATCAGCAGTTTTTAAAGTGCTTCCAGAAATATTAACTTGTTTTAAAATTTTAAGTGTGATAGAA...
AATCCCAGCTACTCAGGAGGCTGAGGCAGAAGAATTGCTTGAACCTGGGAGACAGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAACACAAAAAAACAAAAGAAAGAAAAAAGAAAATTTTATTCATTTTATCAGCTAAAAATACTTAACATTTTTTCACTTTCCTTTCTCTTAAATGTGCTTCATTTGTAATCACTATTATTATCTTACATTTATCAGCAGTTTTTAAAGTGCTTCCAGAAATATTAACTTGTTTTAAAATTTTAAGTGTGATAGAA...
pathogenic
47,608
A mutation at chromosome position 178542739 on chromosome 2 in gene TTN: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
GAGGCTGAGGCAGAAGAATTGCTTGAACCTGGGAGACAGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAACACAAAAAAACAAAAGAAAGAAAAAAGAAAATTTTATTCATTTTATCAGCTAAAAATACTTAACATTTTTTCACTTTCCTTTCTCTTAAATGTGCTTCATTTGTAATCACTATTATTATCTTACATTTATCAGCAGTTTTTAAAGTGCTTCCAGAAATATTAACTTGTTTTAAAATTTTAAGTGTGATAGAAAGCATATATTATGAAT...
GAGGCTGAGGCAGAAGAATTGCTTGAACCTGGGAGACAGAGGTTGCAGTGAGCCAAGATCATGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAACACAAAAAAACAAAAGAAAGAAAAAAGAAAATTTTATTCATTTTATCAGCTAAAAATACTTAACATTTTTTCACTTTCCTTTCTCTTAAATGTGCTTCATTTGTAATCACTATTATTATCTTACATTTATCAGCAGTTTTTAAAGTGCTTCCAGAAATATTAACTTGTTTTAAAATTTTAAGTGTGATAGAAAGCATATATTATGAAT...
pathogenic
47,609
Is the genetic change at chromosome 2, position 178542803, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Primary_dilated_cardiomyopathy', 'Tibial_mu...
CACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAACACAAAAAAACAAAAGAAAGAAAAAAGAAAATTTTATTCATTTTATCAGCTAAAAATACTTAACATTTTTTCACTTTCCTTTCTCTTAAATGTGCTTCATTTGTAATCACTATTATTATCTTACATTTATCAGCAGTTTTTAAAGTGCTTCCAGAAATATTAACTTGTTTTAAAATTTTAAGTGTGATAGAAAGCATATATTATGAATCTCATCTTAAAGAAGTGGAAATTGACTCCAGAGAAGAATATTAAAAATTATTTGCCAGAAATCG...
CACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAAAAAACACAAAAAAACAAAAGAAAGAAAAAAGAAAATTTTATTCATTTTATCAGCTAAAAATACTTAACATTTTTTCACTTTCCTTTCTCTTAAATGTGCTTCATTTGTAATCACTATTATTATCTTACATTTATCAGCAGTTTTTAAAGTGCTTCCAGAAATATTAACTTGTTTTAAAATTTTAAGTGTGATAGAAAGCATATATTATGAATCTCATCTTAAAGAAGTGGAAATTGACTCCAGAGAAGAATATTAAAAATTATTTGCCAGAAATCG...
pathogenic
47,612
Is the chromosome 2, position 178543101 variant in TTN clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy', 'Primary_familial_dilated_cardiomyopathy']
AAAAATTATTTGCCAGAAATCGCTAGCAGCTGGGGTGGGGAAGGGACTGATTACAAACGGACACAAGGGAACTTTACGGGGTAATAAAAATATTCCACATTTTGATTGTGGTGGTGATTACAAAACAGTACATTTTTCAAAAGTCATAGAACTATATATTTCAAAAAGGTGAATTTTCCCACATATAAATTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTC...
AAAAATTATTTGCCAGAAATCGCTAGCAGCTGGGGTGGGGAAGGGACTGATTACAAACGGACACAAGGGAACTTTACGGGGTAATAAAAATATTCCACATTTTGATTGTGGTGGTGATTACAAAACAGTACATTTTTCAAAAGTCATAGAACTATATATTTCAAAAAGGTGAATTTTCCCACATATAAATTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTC...
pathogenic
47,623
Regarding the variant at chromosome 2 and position 178543123, affecting gene TTN: benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTAGCAGCTGGGGTGGGGAAGGGACTGATTACAAACGGACACAAGGGAACTTTACGGGGTAATAAAAATATTCCACATTTTGATTGTGGTGGTGATTACAAAACAGTACATTTTTCAAAAGTCATAGAACTATATATTTCAAAAAGGTGAATTTTCCCACATATAAATTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTCTAAGCCTTCAGTAAGGCCAGTG...
CTAGCAGCTGGGGTGGGGAAGGGACTGATTACAAACGGACACAAGGGAACTTTACGGGGTAATAAAAATATTCCACATTTTGATTGTGGTGGTGATTACAAAACAGTACATTTTTCAAAAGTCATAGAACTATATATTTCAAAAAGGTGAATTTTCCCACATATAAATTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTCTAAGCCTTCAGTAAGGCCAGTG...
pathogenic
47,626
Is the variant located on chromosome 2 at position 178543141, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AAGGGACTGATTACAAACGGACACAAGGGAACTTTACGGGGTAATAAAAATATTCCACATTTTGATTGTGGTGGTGATTACAAAACAGTACATTTTTCAAAAGTCATAGAACTATATATTTCAAAAAGGTGAATTTTCCCACATATAAATTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTCTAAGCCTTCAGTAAGGCCAGTGGAGCGGTACCGTGTCATT...
AAGGGACTGATTACAAACGGACACAAGGGAACTTTACGGGGTAATAAAAATATTCCACATTTTGATTGTGGTGGTGATTACAAAACAGTACATTTTTCAAAAGTCATAGAACTATATATTTCAAAAAGGTGAATTTTCCCACATATAAATTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTCTAAGCCTTCAGTAAGGCCAGTGGAGCGGTACCGTGTCATT...
pathogenic
47,630
Variant on chromosome 2, at position 178543288, affecting TTN: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AATTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTCTAAGCCTTCAGTAAGGCCAGTGGAGCGGTACCGTGTCATTGTCACAGGTACTTTATTTACACGGACCCATCGATCTGCTCTCACTTCTTTGCGCTCCACAATATATCCAGTCACTTGGGAGCCACCGTCATCCTCTGGTGGGTACCAAGTAAGTGTCATGCCATCACGGGAAACATCAAATATCTGT...
AATTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTCTAAGCCTTCAGTAAGGCCAGTGGAGCGGTACCGTGTCATTGTCACAGGTACTTTATTTACACGGACCCATCGATCTGCTCTCACTTCTTTGCGCTCCACAATATATCCAGTCACTTGGGAGCCACCGTCATCCTCTGGTGGGTACCAAGTAAGTGTCATGCCATCACGGGAAACATCAAATATCTGT...
pathogenic
47,636
Is chromosome 2, position 178543290, gene TTN variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTCTAAGCCTTCAGTAAGGCCAGTGGAGCGGTACCGTGTCATTGTCACAGGTACTTTATTTACACGGACCCATCGATCTGCTCTCACTTCTTTGCGCTCCACAATATATCCAGTCACTTGGGAGCCACCGTCATCCTCTGGTGGGTACCAAGTAAGTGTCATGCCATCACGGGAAACATCAAATATCTGTAA...
TTGTAACTCAATCAATTTGACTGATACAAAATGTCCTTACCAATTGGATCCATGGCAACGATGGGTTTGGAAGGACGACTTGGTTTCCCAGACCCTCTTGCATTAATGGCTGTGACACGGTGTTCATATTCTAAGCCTTCAGTAAGGCCAGTGGAGCGGTACCGTGTCATTGTCACAGGTACTTTATTTACACGGACCCATCGATCTGCTCTCACTTCTTTGCGCTCCACAATATATCCAGTCACTTGGGAGCCACCGTCATCCTCTGGTGGGTACCAAGTAAGTGTCATGCCATCACGGGAAACATCAAATATCTGTAA...
pathogenic
47,637
Mutation at chromosome 2, position 178543864, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGCAGTTTGTTACATGGGTATATTGCATGATGCTGAGGTTTAATTTTGTACTTTCCTTGCTGTTCCTCATTTTCTTCAATTCTACATTTATTAAGCATGCACTCTGTATTTTTTTCTCACTATAACATTGCCAGTCCTCCTTCCTTTCCTCTCTTCCTCCTTCCCTTCTCTCTTTTCTTCCTTCCATTCCTTTCTTCCTAACTCCCTCCTCTTCTCTTTCATAAGAGTGAAGATATTAAAAAAAAAATCAAGCCTAAGTGTGTTGAAAACCTCTGAGAAAAGGAGGTTTAGAAACCTGAGAAAAGGAGGTTTAGAAACCT...
TGCAGTTTGTTACATGGGTATATTGCATGATGCTGAGGTTTAATTTTGTACTTTCCTTGCTGTTCCTCATTTTCTTCAATTCTACATTTATTAAGCATGCACTCTGTATTTTTTTCTCACTATAACATTGCCAGTCCTCCTTCCTTTCCTCTCTTCCTCCTTCCCTTCTCTCTTTTCTTCCTTCCATTCCTTTCTTCCTAACTCCCTCCTCTTCTCTTTCATAAGAGTGAAGATATTAAAAAAAAAATCAAGCCTAAGTGTGTTGAAAACCTCTGAGAAAAGGAGGTTTAGAAACCTGAGAAAAGGAGGTTTAGAAACCT...
pathogenic
47,658
Gene TTN variant at chromosome 2, position 178543908—is it benign or pathogenic? If pathogenic, what are the associated condition(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTTGTACTTTCCTTGCTGTTCCTCATTTTCTTCAATTCTACATTTATTAAGCATGCACTCTGTATTTTTTTCTCACTATAACATTGCCAGTCCTCCTTCCTTTCCTCTCTTCCTCCTTCCCTTCTCTCTTTTCTTCCTTCCATTCCTTTCTTCCTAACTCCCTCCTCTTCTCTTTCATAAGAGTGAAGATATTAAAAAAAAAATCAAGCCTAAGTGTGTTGAAAACCTCTGAGAAAAGGAGGTTTAGAAACCTGAGAAAAGGAGGTTTAGAAACCTTAGAAAGACCACAGGGTTAATTTTGTGACCTATTTTTATTTACA...
TTTGTACTTTCCTTGCTGTTCCTCATTTTCTTCAATTCTACATTTATTAAGCATGCACTCTGTATTTTTTTCTCACTATAACATTGCCAGTCCTCCTTCCTTTCCTCTCTTCCTCCTTCCCTTCTCTCTTTTCTTCCTTCCATTCCTTTCTTCCTAACTCCCTCCTCTTCTCTTTCATAAGAGTGAAGATATTAAAAAAAAAATCAAGCCTAAGTGTGTTGAAAACCTCTGAGAAAAGGAGGTTTAGAAACCTGAGAAAAGGAGGTTTAGAAACCTTAGAAAGACCACAGGGTTAATTTTGTGACCTATTTTTATTTACA...
pathogenic
47,659
Considering the variant on chromosome 2, location 178544399, involving gene TTN, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CATTTCCTTCGGTGAGTCTGGTAAACTTAAACGTGGACCTAGTCACTGATTCAGAAACGGGCAGCCATCCTGGACGATGAGCGTCACGTTGTTCTACCACATAACCACTCAGTGGAGCACCACCGTCCAATTCAGGTGGTTCCCAGGAAATGGTAATTGATGTAGCATCAATTTCATCAATCTTAATAGGTCCTGTTGGTGGACCAGGCTTGTCTATGAAAGAGAAGAAATACAGGAAATTAATTTTTACTTCAAATCAAAATTGGGTGACTGAACATCAACTTGCTTGTATCTTTGTCACACATCCTTACCAAGAATGA...
CATTTCCTTCGGTGAGTCTGGTAAACTTAAACGTGGACCTAGTCACTGATTCAGAAACGGGCAGCCATCCTGGACGATGAGCGTCACGTTGTTCTACCACATAACCACTCAGTGGAGCACCACCGTCCAATTCAGGTGGTTCCCAGGAAATGGTAATTGATGTAGCATCAATTTCATCAATCTTAATAGGTCCTGTTGGTGGACCAGGCTTGTCTATGAAAGAGAAGAAATACAGGAAATTAATTTTTACTTCAAATCAAAATTGGGTGACTGAACATCAACTTGCTTGTATCTTTGTCACACATCCTTACCAAGAATGA...
pathogenic
47,683
Variant in gene TTN, located at chromosome 2 position 178544458: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GGCAGCCATCCTGGACGATGAGCGTCACGTTGTTCTACCACATAACCACTCAGTGGAGCACCACCGTCCAATTCAGGTGGTTCCCAGGAAATGGTAATTGATGTAGCATCAATTTCATCAATCTTAATAGGTCCTGTTGGTGGACCAGGCTTGTCTATGAAAGAGAAGAAATACAGGAAATTAATTTTTACTTCAAATCAAAATTGGGTGACTGAACATCAACTTGCTTGTATCTTTGTCACACATCCTTACCAAGAATGATAACTTTAATGGTTTCTGAAGTAGTTCCGGTAACATTCTTCAATTCAAGTGTGTATTCT...
GGCAGCCATCCTGGACGATGAGCGTCACGTTGTTCTACCACATAACCACTCAGTGGAGCACCACCGTCCAATTCAGGTGGTTCCCAGGAAATGGTAATTGATGTAGCATCAATTTCATCAATCTTAATAGGTCCTGTTGGTGGACCAGGCTTGTCTATGAAAGAGAAGAAATACAGGAAATTAATTTTTACTTCAAATCAAAATTGGGTGACTGAACATCAACTTGCTTGTATCTTTGTCACACATCCTTACCAAGAATGATAACTTTAATGGTTTCTGAAGTAGTTCCGGTAACATTCTTCAATTCAAGTGTGTATTCT...
pathogenic
47,685
Is the genetic change at chromosome 2, position 178545640, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TTCCCAAGTTATAGTCACAGAATCTCTTGATACTTCCTTAACTTTCACTGAAGGACAGGGACCAGGAGTATCTGAAAAACAGAATGAAAGATTCATATTTCCTATTTGCCTGATAGCTTTTTTTTTCTTGGGGAAATATAATCAACATAGTTCCTTTCTAGAGAGGTGATCAATCATAGGTCAAGCTATATTGTTTTAGAGGATCTACTCATTGTATAGCCAATTTTAAGTAAAATGCTTACCATAGACTTTAACAAGGACTGTTGCTGATTTCTTGCCAGATTGGTTTTCAGCTTCAATTGTGTATTTTCCAGCATCGT...
TTCCCAAGTTATAGTCACAGAATCTCTTGATACTTCCTTAACTTTCACTGAAGGACAGGGACCAGGAGTATCTGAAAAACAGAATGAAAGATTCATATTTCCTATTTGCCTGATAGCTTTTTTTTTCTTGGGGAAATATAATCAACATAGTTCCTTTCTAGAGAGGTGATCAATCATAGGTCAAGCTATATTGTTTTAGAGGATCTACTCATTGTATAGCCAATTTTAAGTAAAATGCTTACCATAGACTTTAACAAGGACTGTTGCTGATTTCTTGCCAGATTGGTTTTCAGCTTCAATTGTGTATTTTCCAGCATCGT...
pathogenic
47,704
A mutation at chromosome position 178545969 on chromosome 2 in gene TTN: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CTTTGTCCACTATTAGCAATGAGTAGCTCTCAGTGGTGTCAATAATTGCCCGGCTTGCAAGGTCAATGCCCTGCTTGCTCCACGTTATGACAGGAGGTGGTCTTCCAGATACAGACACCATCAAGCGCAAGGAGGCCCCAGCCCTGATGGTCACAGTCTTCTTTAGATCATCTGCAAGCTCAAGATCTGGTATTTCTGGAAAGTTAATGACAAAATTTAATTAATTCATGGACAGGTGTGAGAAGAAAATAATTCACCTAAAAGCTTCTGTGATAAATACCTATTCTTTCCACGGGCTCAATTTCAGCAATTGATTCGCT...
CTTTGTCCACTATTAGCAATGAGTAGCTCTCAGTGGTGTCAATAATTGCCCGGCTTGCAAGGTCAATGCCCTGCTTGCTCCACGTTATGACAGGAGGTGGTCTTCCAGATACAGACACCATCAAGCGCAAGGAGGCCCCAGCCCTGATGGTCACAGTCTTCTTTAGATCATCTGCAAGCTCAAGATCTGGTATTTCTGGAAAGTTAATGACAAAATTTAATTAATTCATGGACAGGTGTGAGAAGAAAATAATTCACCTAAAAGCTTCTGTGATAAATACCTATTCTTTCCACGGGCTCAATTTCAGCAATTGATTCGCT...
pathogenic
47,715
Clinical classification of chromosome 2, position 178546255, gene TTN: benign or pathogenic? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G']
TTTCCACGGGCTCAATTTCAGCAATTGATTCGCTGTATTCGCTCATACCCTTCACGTTCACGGCAGCAACTCTGAAGGAATATTTCTGGCCCATTTTAAGGTCTGGCACAGTGAATTCAGTATTTCTTATTGTGGCATTGGTATGCACTCGGTACCACTGATCAGTGTCCTTCTCTTGCATTTCCAGAACATATCCTACAATGTCAGTACCACCATCGTACATGGGTTTGGTCCATGCCAAACTAATGCTGTGTTTGGTGGTATCCACAACTCTTGGAGCAGAAGGTGGTCCAGGGGTATCTGTGGAATTTAAAAAGTGA...
TTTCCACGGGCTCAATTTCAGCAATTGATTCGCTGTATTCGCTCATACCCTTCACGTTCACGGCAGCAACTCTGAAGGAATATTTCTGGCCCATTTTAAGGTCTGGCACAGTGAATTCAGTATTTCTTATTGTGGCATTGGTATGCACTCGGTACCACTGATCAGTGTCCTTCTCTTGCATTTCCAGAACATATCCTACAATGTCAGTACCACCATCGTACATGGGTTTGGTCCATGCCAAACTAATGCTGTGTTTGGTGGTATCCACAACTCTTGGAGCAGAAGGTGGTCCAGGGGTATCTGTGGAATTTAAAAAGTGA...
pathogenic
47,724
Is the genetic change at chromosome 2, position 178546306, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TCACGTTCACGGCAGCAACTCTGAAGGAATATTTCTGGCCCATTTTAAGGTCTGGCACAGTGAATTCAGTATTTCTTATTGTGGCATTGGTATGCACTCGGTACCACTGATCAGTGTCCTTCTCTTGCATTTCCAGAACATATCCTACAATGTCAGTACCACCATCGTACATGGGTTTGGTCCATGCCAAACTAATGCTGTGTTTGGTGGTATCCACAACTCTTGGAGCAGAAGGTGGTCCAGGGGTATCTGTGGAATTTAAAAAGTGAGATGCAGATATTAGGCAAATAAGGAAATGTTGAGATTTGTATTTTTTGTTT...
TCACGTTCACGGCAGCAACTCTGAAGGAATATTTCTGGCCCATTTTAAGGTCTGGCACAGTGAATTCAGTATTTCTTATTGTGGCATTGGTATGCACTCGGTACCACTGATCAGTGTCCTTCTCTTGCATTTCCAGAACATATCCTACAATGTCAGTACCACCATCGTACATGGGTTTGGTCCATGCCAAACTAATGCTGTGTTTGGTGGTATCCACAACTCTTGGAGCAGAAGGTGGTCCAGGGGTATCTGTGGAATTTAAAAAGTGAGATGCAGATATTAGGCAAATAAGGAAATGTTGAGATTTGTATTTTTTGTTT...
pathogenic
47,728
Is the variant located on chromosome 2 at position 178546426, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
TCTCTTGCATTTCCAGAACATATCCTACAATGTCAGTACCACCATCGTACATGGGTTTGGTCCATGCCAAACTAATGCTGTGTTTGGTGGTATCCACAACTCTTGGAGCAGAAGGTGGTCCAGGGGTATCTGTGGAATTTAAAAAGTGAGATGCAGATATTAGGCAAATAAGGAAATGTTGAGATTTGTATTTTTTGTTTTCAAGACTCACAAAGGCATTATTGCTCTTGTCCACACTCACCAAGATAATCTTTATTAACTGGGCTCCTGATATTATAGGACAGCACAGAGTGCCACATTATAATTTAATATTATTATCT...
TCTCTTGCATTTCCAGAACATATCCTACAATGTCAGTACCACCATCGTACATGGGTTTGGTCCATGCCAAACTAATGCTGTGTTTGGTGGTATCCACAACTCTTGGAGCAGAAGGTGGTCCAGGGGTATCTGTGGAATTTAAAAAGTGAGATGCAGATATTAGGCAAATAAGGAAATGTTGAGATTTGTATTTTTTGTTTTCAAGACTCACAAAGGCATTATTGCTCTTGTCCACACTCACCAAGATAATCTTTATTAACTGGGCTCCTGATATTATAGGACAGCACAGAGTGCCACATTATAATTTAATATTATTATCT...
pathogenic
47,733
Chromosome 2, position 178546621, gene TTN: Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
TGTTTTCAAGACTCACAAAGGCATTATTGCTCTTGTCCACACTCACCAAGATAATCTTTATTAACTGGGCTCCTGATATTATAGGACAGCACAGAGTGCCACATTATAATTTAATATTATTATCTTAAGAATTAAATTGCTTTAGGAAAGTAGATATTTCTTCCCTACTTCTTTGGCCAGCTTTACTGTGTGTTCTCTATTAGCTAAGCTCATTACTTAAAGTACCCATTCTTAGGGACTTTTCTTTAGTTGCTTATCTTTCACTGGGTTAGTATCACTTGCCACCAATACATTTCTAATGAATACAAGAATTGGTTTCC...
TGTTTTCAAGACTCACAAAGGCATTATTGCTCTTGTCCACACTCACCAAGATAATCTTTATTAACTGGGCTCCTGATATTATAGGACAGCACAGAGTGCCACATTATAATTTAATATTATTATCTTAAGAATTAAATTGCTTTAGGAAAGTAGATATTTCTTCCCTACTTCTTTGGCCAGCTTTACTGTGTGTTCTCTATTAGCTAAGCTCATTACTTAAAGTACCCATTCTTAGGGACTTTTCTTTAGTTGCTTATCTTTCACTGGGTTAGTATCACTTGCCACCAATACATTTCTAATGAATACAAGAATTGGTTTCC...
pathogenic
47,742
Variant in TTN, chromosome 2, position 178547177—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
GATTCTTTTCATATTGATAGAATATTTTTTCATTAATTGGAAAATGCTGTACAACTTTTAGCAATTCTAATTGCTAACTTAACAGATGTAATAGTTAAAATGTTCTCTGACTTAAGCTATATTTATGATCATGCAAATAAGCATGTGCTTTTCTAGACCATTCATAAATTCTAAAAATTCTTAGAGATTGTGTGTTGGAAAATTATCTGTCATATAGTTTTGAGGAGCATTGTATTTATGTATGATTCTTGGAGCTCACATGATGGTTCTCTGCATGAGATGAAGTTGGAAGCTTCGCTGGGCTCACTGTTACCAGCTGC...
GATTCTTTTCATATTGATAGAATATTTTTTCATTAATTGGAAAATGCTGTACAACTTTTAGCAATTCTAATTGCTAACTTAACAGATGTAATAGTTAAAATGTTCTCTGACTTAAGCTATATTTATGATCATGCAAATAAGCATGTGCTTTTCTAGACCATTCATAAATTCTAAAAATTCTTAGAGATTGTGTGTTGGAAAATTATCTGTCATATAGTTTTGAGGAGCATTGTATTTATGTATGATTCTTGGAGCTCACATGATGGTTCTCTGCATGAGATGAAGTTGGAAGCTTCGCTGGGCTCACTGTTACCAGCTGC...
pathogenic
47,766
Regarding the variant at chromosome 2 and position 178547446, affecting gene TTN: benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Primary_dilated_cardiomyopathy', 'Tibial_mu...
TCTGCATGAGATGAAGTTGGAAGCTTCGCTGGGCTCACTGTTACCAGCTGCATTCACTGCGGTCACCCGGAACTGGTAATCACAACCCTCCATCAGGCTGGTCACCTTCAGCCTGGTATCATACACCACATAGTCTTTGTTGACACGTGTCCAGCGCAGGCTCTTCTTCTCACGTTTGTCTACTAGGTAGTTGCTGATTTCATTGCCACCATCAGATTCAGGTTTTGTCCACTGAATGATGATATGCTCTTTGCCAGTCCCAACTTCTTCAGGTATGCCGGGTGGTGATGGAATAGCTGTTTATGAAAATAAGGATGATG...
TCTGCATGAGATGAAGTTGGAAGCTTCGCTGGGCTCACTGTTACCAGCTGCATTCACTGCGGTCACCCGGAACTGGTAATCACAACCCTCCATCAGGCTGGTCACCTTCAGCCTGGTATCATACACCACATAGTCTTTGTTGACACGTGTCCAGCGCAGGCTCTTCTTCTCACGTTTGTCTACTAGGTAGTTGCTGATTTCATTGCCACCATCAGATTCAGGTTTTGTCCACTGAATGATGATATGCTCTTTGCCAGTCCCAACTTCTTCAGGTATGCCGGGTGGTGATGGAATAGCTGTTTATGAAAATAAGGATGATG...
pathogenic
47,772
A genetic alteration at chromosome 2, position 178547458, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GAAGTTGGAAGCTTCGCTGGGCTCACTGTTACCAGCTGCATTCACTGCGGTCACCCGGAACTGGTAATCACAACCCTCCATCAGGCTGGTCACCTTCAGCCTGGTATCATACACCACATAGTCTTTGTTGACACGTGTCCAGCGCAGGCTCTTCTTCTCACGTTTGTCTACTAGGTAGTTGCTGATTTCATTGCCACCATCAGATTCAGGTTTTGTCCACTGAATGATGATATGCTCTTTGCCAGTCCCAACTTCTTCAGGTATGCCGGGTGGTGATGGAATAGCTGTTTATGAAAATAAGGATGATGAGAATTGCACAA...
GAAGTTGGAAGCTTCGCTGGGCTCACTGTTACCAGCTGCATTCACTGCGGTCACCCGGAACTGGTAATCACAACCCTCCATCAGGCTGGTCACCTTCAGCCTGGTATCATACACCACATAGTCTTTGTTGACACGTGTCCAGCGCAGGCTCTTCTTCTCACGTTTGTCTACTAGGTAGTTGCTGATTTCATTGCCACCATCAGATTCAGGTTTTGTCCACTGAATGATGATATGCTCTTTGCCAGTCCCAACTTCTTCAGGTATGCCGGGTGGTGATGGAATAGCTGTTTATGAAAATAAGGATGATGAGAATTGCACAA...
pathogenic
47,773
Determine if the mutation at chromosome 2, position 178547518 in gene TTN is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Mitral_valve_prolapse']
CTGGTAATCACAACCCTCCATCAGGCTGGTCACCTTCAGCCTGGTATCATACACCACATAGTCTTTGTTGACACGTGTCCAGCGCAGGCTCTTCTTCTCACGTTTGTCTACTAGGTAGTTGCTGATTTCATTGCCACCATCAGATTCAGGTTTTGTCCACTGAATGATGATATGCTCTTTGCCAGTCCCAACTTCTTCAGGTATGCCGGGTGGTGATGGAATAGCTGTTTATGAAAATAAGGATGATGAGAATTGCACAAAATTACTATTGATAAGACTGCCCTTCTCCCTTCTCCCCCTGATTCTATTACATTTCAACT...
CTGGTAATCACAACCCTCCATCAGGCTGGTCACCTTCAGCCTGGTATCATACACCACATAGTCTTTGTTGACACGTGTCCAGCGCAGGCTCTTCTTCTCACGTTTGTCTACTAGGTAGTTGCTGATTTCATTGCCACCATCAGATTCAGGTTTTGTCCACTGAATGATGATATGCTCTTTGCCAGTCCCAACTTCTTCAGGTATGCCGGGTGGTGATGGAATAGCTGTTTATGAAAATAAGGATGATGAGAATTGCACAAAATTACTATTGATAAGACTGCCCTTCTCCCTTCTCCCCCTGATTCTATTACATTTCAACT...
pathogenic
47,774
Does the variant on chromosome 2 at location 178547728 affecting gene TTN have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
TGGTGATGGAATAGCTGTTTATGAAAATAAGGATGATGAGAATTGCACAAAATTACTATTGATAAGACTGCCCTTCTCCCTTCTCCCCCTGATTCTATTACATTTCAACTGTCAAATTATTTAAAAGTGTTAATACTTACTGAATGAGTTTCTGGCTACAATTGGCTCTGATTCAACAGGCACACCAGGGCCATATTTGTTTACTGCCCTCACTCGGAATATGTACTCATTGTTCTTGATGAGCCTGGTAACGACATAGGATAGGGTTGGGCATTCGCCTTCAACAATCACCCAGTTGAGCCTGCTAGTCTCGCGTCTTT...
TGGTGATGGAATAGCTGTTTATGAAAATAAGGATGATGAGAATTGCACAAAATTACTATTGATAAGACTGCCCTTCTCCCTTCTCCCCCTGATTCTATTACATTTCAACTGTCAAATTATTTAAAAGTGTTAATACTTACTGAATGAGTTTCTGGCTACAATTGGCTCTGATTCAACAGGCACACCAGGGCCATATTTGTTTACTGCCCTCACTCGGAATATGTACTCATTGTTCTTGATGAGCCTGGTAACGACATAGGATAGGGTTGGGCATTCGCCTTCAACAATCACCCAGTTGAGCCTGCTAGTCTCGCGTCTTT...
pathogenic
47,785
A genetic variant at chromosome 2, position 178547890, affecting gene TTN—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGGCTCTGATTCAACAGGCACACCAGGGCCATATTTGTTTACTGCCCTCACTCGGAATATGTACTCATTGTTCTTGATGAGCCTGGTAACGACATAGGATAGGGTTGGGCATTCGCCTTCAACAATCACCCAGTTGAGCCTGCTAGTCTCGCGTCTTTCCACGATGTAGTGAGTGATTTCTGCTCCTCCGTCTTCCTGCGGAAGGCTCCAGGCTAAAGTGCACTTCTCCTGTGTTACTCTGCTGACGGTGAGCTTTCCACATGGGCCAGGGGAATCTGAAACAGGTGTAATGACAAGCCATGATGAAGATCATTCTTTCT...
TGGCTCTGATTCAACAGGCACACCAGGGCCATATTTGTTTACTGCCCTCACTCGGAATATGTACTCATTGTTCTTGATGAGCCTGGTAACGACATAGGATAGGGTTGGGCATTCGCCTTCAACAATCACCCAGTTGAGCCTGCTAGTCTCGCGTCTTTCCACGATGTAGTGAGTGATTTCTGCTCCTCCGTCTTCCTGCGGAAGGCTCCAGGCTAAAGTGCACTTCTCCTGTGTTACTCTGCTGACGGTGAGCTTTCCACATGGGCCAGGGGAATCTGAAACAGGTGTAATGACAAGCCATGATGAAGATCATTCTTTCT...
pathogenic
47,789
The chromosome 2, position 178547984 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TAGGATAGGGTTGGGCATTCGCCTTCAACAATCACCCAGTTGAGCCTGCTAGTCTCGCGTCTTTCCACGATGTAGTGAGTGATTTCTGCTCCTCCGTCTTCCTGCGGAAGGCTCCAGGCTAAAGTGCACTTCTCCTGTGTTACTCTGCTGACGGTGAGCTTTCCACATGGGCCAGGGGAATCTGAAACAGGTGTAATGACAAGCCATGATGAAGATCATTCTTTCTGCCCACACTGGAAAATGCTATATAAATGTGAGAACATTTGACATGCTTACCAAGCACTTTGACCATGACAGACACGGCCTTGGTCCCGCTGGCA...
TAGGATAGGGTTGGGCATTCGCCTTCAACAATCACCCAGTTGAGCCTGCTAGTCTCGCGTCTTTCCACGATGTAGTGAGTGATTTCTGCTCCTCCGTCTTCCTGCGGAAGGCTCCAGGCTAAAGTGCACTTCTCCTGTGTTACTCTGCTGACGGTGAGCTTTCCACATGGGCCAGGGGAATCTGAAACAGGTGTAATGACAAGCCATGATGAAGATCATTCTTTCTGCCCACACTGGAAAATGCTATATAAATGTGAGAACATTTGACATGCTTACCAAGCACTTTGACCATGACAGACACGGCCTTGGTCCCGCTGGCA...
pathogenic
47,794
Does the chromosome 2 mutation at position 178548225 within gene TTN classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGCTATATAAATGTGAGAACATTTGACATGCTTACCAAGCACTTTGACCATGACAGACACGGCCTTGGTCCCGCTGGCATTTTTCACTGTTAAAGTGTATTTTCCACTGTCACTTCTGTCACAGAACTTGATCACAGCAGTTGCTCGTTTGCCAGTATACTGCAAAGAGACTTTTTCACAGAGATCTAGCTCCTTGTCTCCTTTGGTCCAGATAATTTTGGGTTCAGGTTTGCCACCAACTGCAGCATCCAGAACAAGATCAGAACCTGCTCTGATGGTAACCAGATCACCGTGTAATCGGGCATCCAGTTCGGCTTTGG...
TGCTATATAAATGTGAGAACATTTGACATGCTTACCAAGCACTTTGACCATGACAGACACGGCCTTGGTCCCGCTGGCATTTTTCACTGTTAAAGTGTATTTTCCACTGTCACTTCTGTCACAGAACTTGATCACAGCAGTTGCTCGTTTGCCAGTATACTGCAAAGAGACTTTTTCACAGAGATCTAGCTCCTTGTCTCCTTTGGTCCAGATAATTTTGGGTTCAGGTTTGCCACCAACTGCAGCATCCAGAACAAGATCAGAACCTGCTCTGATGGTAACCAGATCACCGTGTAATCGGGCATCCAGTTCGGCTTTGG...
pathogenic
47,812
Is the genetic variant on chromosome 2, position 178548966, gene TTN, benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CAAAAATAAGGTTAAAATATACCACTCTGAGTTCTACTAGAATCAGTAATAATAAACAAATATGCCCTTAAATTGTGATACATACCAACTGGATTTTGAGCCATTATAGGTCTTGAAGCTTCGCTGGCCTTGCTAACACCTGCAGCATTGAGTGCATAAGTTCTGAACTGATATTCCAGTCCTTCTACTAAACCAGTTACTTTGTAGTTGCACTCTAAGCATGGCACTTTGTTTTCTTTCACCCAAAGAATTGTATTACGTTCTTTCTTCTCAACCCAGTAGCCAATGATTTTACTGCCACCATCGTGGTAGGGTTCTTC...
CAAAAATAAGGTTAAAATATACCACTCTGAGTTCTACTAGAATCAGTAATAATAAACAAATATGCCCTTAAATTGTGATACATACCAACTGGATTTTGAGCCATTATAGGTCTTGAAGCTTCGCTGGCCTTGCTAACACCTGCAGCATTGAGTGCATAAGTTCTGAACTGATATTCCAGTCCTTCTACTAAACCAGTTACTTTGTAGTTGCACTCTAAGCATGGCACTTTGTTTTCTTTCACCCAAAGAATTGTATTACGTTCTTTCTTCTCAACCCAGTAGCCAATGATTTTACTGCCACCATCGTGGTAGGGTTCTTC...
pathogenic
47,845
Is chromosome 2, position 178548994, gene TTN variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
GAGTTCTACTAGAATCAGTAATAATAAACAAATATGCCCTTAAATTGTGATACATACCAACTGGATTTTGAGCCATTATAGGTCTTGAAGCTTCGCTGGCCTTGCTAACACCTGCAGCATTGAGTGCATAAGTTCTGAACTGATATTCCAGTCCTTCTACTAAACCAGTTACTTTGTAGTTGCACTCTAAGCATGGCACTTTGTTTTCTTTCACCCAAAGAATTGTATTACGTTCTTTCTTCTCAACCCAGTAGCCAATGATTTTACTGCCACCATCGTGGTAGGGTTCTTCCCAACGAATAGACATGGCATTGGCAGAC...
GAGTTCTACTAGAATCAGTAATAATAAACAAATATGCCCTTAAATTGTGATACATACCAACTGGATTTTGAGCCATTATAGGTCTTGAAGCTTCGCTGGCCTTGCTAACACCTGCAGCATTGAGTGCATAAGTTCTGAACTGATATTCCAGTCCTTCTACTAAACCAGTTACTTTGTAGTTGCACTCTAAGCATGGCACTTTGTTTTCTTTCACCCAAAGAATTGTATTACGTTCTTTCTTCTCAACCCAGTAGCCAATGATTTTACTGCCACCATCGTGGTAGGGTTCTTCCCAACGAATAGACATGGCATTGGCAGAC...
pathogenic
47,848
The chromosome 2, position 178549055 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
TGGATTTTGAGCCATTATAGGTCTTGAAGCTTCGCTGGCCTTGCTAACACCTGCAGCATTGAGTGCATAAGTTCTGAACTGATATTCCAGTCCTTCTACTAAACCAGTTACTTTGTAGTTGCACTCTAAGCATGGCACTTTGTTTTCTTTCACCCAAAGAATTGTATTACGTTCTTTCTTCTCAACCCAGTAGCCAATGATTTTACTGCCACCATCGTGGTAGGGTTCTTCCCAACGAATAGACATGGCATTGGCAGACACATGGTAGACCTCAGGTCTGGTAGGAGCGCTTGGTGGGACTAAATATAAACAAAGGTATT...
TGGATTTTGAGCCATTATAGGTCTTGAAGCTTCGCTGGCCTTGCTAACACCTGCAGCATTGAGTGCATAAGTTCTGAACTGATATTCCAGTCCTTCTACTAAACCAGTTACTTTGTAGTTGCACTCTAAGCATGGCACTTTGTTTTCTTTCACCCAAAGAATTGTATTACGTTCTTTCTTCTCAACCCAGTAGCCAATGATTTTACTGCCACCATCGTGGTAGGGTTCTTCCCAACGAATAGACATGGCATTGGCAGACACATGGTAGACCTCAGGTCTGGTAGGAGCGCTTGGTGGGACTAAATATAAACAAAGGTATT...
pathogenic
47,850
Mutation found at chromosome 2 position 178549337, gene TTN: benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
AGGAGCGCTTGGTGGGACTAAATATAAACAAAGGTATTAAGTATGAATACAATTTTATAAAATTCAGGGGAAACATTTAATAATAGAGACTTTGAAATAGGATTTTTATTTTTCTTACCAAATGGATGTTCAGCAATTATTGGTGCTGATTCTAGAGGTTTGCTGACACCAAATCTGTTCTCTGAACTGACACGGAAAGAATATTCCATGTATTTTGTGAGATGAGTGACTTTAATTTGAGTGCGCTTGACACTGGAATTGACAAGCTGCCAAGCTGTTGTACCCGATTCACGCTTTTCAACTATGTAATTAGTAATTTC...
AGGAGCGCTTGGTGGGACTAAATATAAACAAAGGTATTAAGTATGAATACAATTTTATAAAATTCAGGGGAAACATTTAATAATAGAGACTTTGAAATAGGATTTTTATTTTTCTTACCAAATGGATGTTCAGCAATTATTGGTGCTGATTCTAGAGGTTTGCTGACACCAAATCTGTTCTCTGAACTGACACGGAAAGAATATTCCATGTATTTTGTGAGATGAGTGACTTTAATTTGAGTGCGCTTGACACTGGAATTGACAAGCTGCCAAGCTGTTGTACCCGATTCACGCTTTTCAACTATGTAATTAGTAATTTC...
pathogenic
47,862
A genetic variant on chromosome 2, position 178549388, affects the gene TTN. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
ATTTTATAAAATTCAGGGGAAACATTTAATAATAGAGACTTTGAAATAGGATTTTTATTTTTCTTACCAAATGGATGTTCAGCAATTATTGGTGCTGATTCTAGAGGTTTGCTGACACCAAATCTGTTCTCTGAACTGACACGGAAAGAATATTCCATGTATTTTGTGAGATGAGTGACTTTAATTTGAGTGCGCTTGACACTGGAATTGACAAGCTGCCAAGCTGTTGTACCCGATTCACGCTTTTCAACTATGTAATTAGTAATTTCAGTGCCTCCTCCATCTTTAGGTTCTCCCCATGACAGGACACACGATTCAGC...
ATTTTATAAAATTCAGGGGAAACATTTAATAATAGAGACTTTGAAATAGGATTTTTATTTTTCTTACCAAATGGATGTTCAGCAATTATTGGTGCTGATTCTAGAGGTTTGCTGACACCAAATCTGTTCTCTGAACTGACACGGAAAGAATATTCCATGTATTTTGTGAGATGAGTGACTTTAATTTGAGTGCGCTTGACACTGGAATTGACAAGCTGCCAAGCTGTTGTACCCGATTCACGCTTTTCAACTATGTAATTAGTAATTTCAGTGCCTCCTCCATCTTTAGGTTCTCCCCATGACAGGACACACGATTCAGC...
pathogenic
47,865
A mutation at chromosome position 178549846 on chromosome 2 in gene TTN: benign or pathogenic? If pathogenic, which disease(s) is it linked to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CTTTACAGTCAGTGTGGTTCTGTCTTTTGTTGTTGTAATGCTCACTCGATCTGTCTCTTTAAGTCTCATTTCTTCCAGTTTCCATGTTACTTTGGGGGCAGGACGACCACTGATTGGTACGTCAATGGTAAATGGGCTTCCTGCTTTGCAAGTTATAAGCTGATTGGTAATTCCAGTGAGGTCAGCAGTGGGCTCGATTTGAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAG...
CTTTACAGTCAGTGTGGTTCTGTCTTTTGTTGTTGTAATGCTCACTCGATCTGTCTCTTTAAGTCTCATTTCTTCCAGTTTCCATGTTACTTTGGGGGCAGGACGACCACTGATTGGTACGTCAATGGTAAATGGGCTTCCTGCTTTGCAAGTTATAAGCTGATTGGTAATTCCAGTGAGGTCAGCAGTGGGCTCGATTTGAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAG...
pathogenic
47,879
Benign or pathogenic: chromosome 2, position 178549862, gene TTN variant? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GTTCTGTCTTTTGTTGTTGTAATGCTCACTCGATCTGTCTCTTTAAGTCTCATTTCTTCCAGTTTCCATGTTACTTTGGGGGCAGGACGACCACTGATTGGTACGTCAATGGTAAATGGGCTTCCTGCTTTGCAAGTTATAAGCTGATTGGTAATTCCAGTGAGGTCAGCAGTGGGCTCGATTTGAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTG...
GTTCTGTCTTTTGTTGTTGTAATGCTCACTCGATCTGTCTCTTTAAGTCTCATTTCTTCCAGTTTCCATGTTACTTTGGGGGCAGGACGACCACTGATTGGTACGTCAATGGTAAATGGGCTTCCTGCTTTGCAAGTTATAAGCTGATTGGTAATTCCAGTGAGGTCAGCAGTGGGCTCGATTTGAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTG...
pathogenic
47,880
Variant in gene TTN, located at chromosome 2 position 178549998: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy', 'Primary_familial_dilated_cardiomyopathy']
TTATAAGCTGATTGGTAATTCCAGTGAGGTCAGCAGTGGGCTCGATTTGAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTGACCAGCTTCAACCCAGAAGTCAGATCCCTTTTGTCTCATTTCAAGCAGGTAGCCAGTGATCCGGCTGCCTCCATCGTGGTCAGGTTTAAGCCAAGCTAAGACTGCGGAGGATTTGCTAGTATCAACAACATCAAGT...
TTATAAGCTGATTGGTAATTCCAGTGAGGTCAGCAGTGGGCTCGATTTGAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTGACCAGCTTCAACCCAGAAGTCAGATCCCTTTTGTCTCATTTCAAGCAGGTAGCCAGTGATCCGGCTGCCTCCATCGTGGTCAGGTTTAAGCCAAGCTAAGACTGCGGAGGATTTGCTAGTATCAACAACATCAAGT...
pathogenic
47,883
Benign or pathogenic: chromosome 2, position 178550039, gene TTN variant? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TCGATTTGAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTGACCAGCTTCAACCCAGAAGTCAGATCCCTTTTGTCTCATTTCAAGCAGGTAGCCAGTGATCCGGCTGCCTCCATCGTGGTCAGGTTTAAGCCAAGCTAAGACTGCGGAGGATTTGCTAGTATCAACAACATCAAGTCTCCTAGGTGGAGCAGGCTGTTCTGTGGCTACAATTGGTTC...
TCGATTTGAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTGACCAGCTTCAACCCAGAAGTCAGATCCCTTTTGTCTCATTTCAAGCAGGTAGCCAGTGATCCGGCTGCCTCCATCGTGGTCAGGTTTAAGCCAAGCTAAGACTGCGGAGGATTTGCTAGTATCAACAACATCAAGTCTCCTAGGTGGAGCAGGCTGTTCTGTGGCTACAATTGGTTC...
pathogenic
47,886
The chromosome 2, position 178550046 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTGACCAGCTTCAACCCAGAAGTCAGATCCCTTTTGTCTCATTTCAAGCAGGTAGCCAGTGATCCGGCTGCCTCCATCGTGGTCAGGTTTAAGCCAAGCTAAGACTGCGGAGGATTTGCTAGTATCAACAACATCAAGTCTCCTAGGTGGAGCAGGCTGTTCTGTGGCTACAATTGGTTCTGGCATT...
GAGGCTCCTTAATGATGACAGAAGAGAAGGCTTCTCTGGGTTCACTATAGCCAGCATCATTCTTGGCCTTCACACGGAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTGACCAGCTTCAACCCAGAAGTCAGATCCCTTTTGTCTCATTTCAAGCAGGTAGCCAGTGATCCGGCTGCCTCCATCGTGGTCAGGTTTAAGCCAAGCTAAGACTGCGGAGGATTTGCTAGTATCAACAACATCAAGTCTCCTAGGTGGAGCAGGCTGTTCTGTGGCTACAATTGGTTCTGGCATT...
pathogenic
47,887
Clinical impact (benign or pathogenic) of the variant at chromosome 2, location 178550122, gene TTN: what disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
GAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTGACCAGCTTCAACCCAGAAGTCAGATCCCTTTTGTCTCATTTCAAGCAGGTAGCCAGTGATCCGGCTGCCTCCATCGTGGTCAGGTTTAAGCCAAGCTAAGACTGCGGAGGATTTGCTAGTATCAACAACATCAAGTCTCCTAGGTGGAGCAGGCTGTTCTGTGGCTACAATTGGTTCTGGCATTTCATAGGGCTCACCAACACCATACTCATTTACTGCAGAAACACGGAAATAGTACGGAACACCTTCGGCCAGGTCAT...
GAATTCATATTCAGTTTTCTCAACAAGACGCTCTACTGTGAAAGTTAGCTGTTTGGTGTGACCAGCTTCAACCCAGAAGTCAGATCCCTTTTGTCTCATTTCAAGCAGGTAGCCAGTGATCCGGCTGCCTCCATCGTGGTCAGGTTTAAGCCAAGCTAAGACTGCGGAGGATTTGCTAGTATCAACAACATCAAGTCTCCTAGGTGGAGCAGGCTGTTCTGTGGCTACAATTGGTTCTGGCATTTCATAGGGCTCACCAACACCATACTCATTTACTGCAGAAACACGGAAATAGTACGGAACACCTTCGGCCAGGTCAT...
pathogenic
47,890