question
stringlengths
84
268
answer
stringlengths
6
879
reference_sequence
stringlengths
4.1k
4.1k
mutated_sequence
stringlengths
4.1k
4.1k
cleaned_pathogenicity
stringclasses
2 values
__index_level_0__
int64
67
343k
Mutation at chromosome 2, position 178551084, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CGGCCTTACACATTTCAATAATATACCCAATTATTTCCATGCCACCATCAAACACTGGTTTGGACCATTCTAAGCTCACAGTTGTCTTTGATGTGTCTGTTACTTTGACCACTGTGGGAGGACCTGGTGGGTTGACGGGCTCTCTACATTTAATGAGTCTTGAGATGCCACTTGCAGGTCCAACTCCTGCAGCATTTTCAGCCATGACATGGAATTCATACTCATTGCCTTCTGTCAGACCAGTGACTTTGAATCTTGTTTCAGAGATTGGTCGTTTGCTGATCACTTTTACCCATCTTGTGCTTTTCTTTTCTCTTCTT...
CGGCCTTACACATTTCAATAATATACCCAATTATTTCCATGCCACCATCAAACACTGGTTTGGACCATTCTAAGCTCACAGTTGTCTTTGATGTGTCTGTTACTTTGACCACTGTGGGAGGACCTGGTGGGTTGACGGGCTCTCTACATTTAATGAGTCTTGAGATGCCACTTGCAGGTCCAACTCCTGCAGCATTTTCAGCCATGACATGGAATTCATACTCATTGCCTTCTGTCAGACCAGTGACTTTGAATCTTGTTTCAGAGATTGGTCGTTTGCTGATCACTTTTACCCATCTTGTGCTTTTCTTTTCTCTTCTT...
pathogenic
47,907
Variant in gene TTN, located at chromosome 2 position 178551188: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Cardiovascular_phenotype', 'Primary_dilated_cardiomyopathy']
TTGACCACTGTGGGAGGACCTGGTGGGTTGACGGGCTCTCTACATTTAATGAGTCTTGAGATGCCACTTGCAGGTCCAACTCCTGCAGCATTTTCAGCCATGACATGGAATTCATACTCATTGCCTTCTGTCAGACCAGTGACTTTGAATCTTGTTTCAGAGATTGGTCGTTTGCTGATCACTTTTACCCATCTTGTGCTTTTCTTTTCTCTTCTTTCAAGGATATACTGTTGAATTTCACTGCCACCATCTGATTCTGGCCTTGCCCATGTCAGGGTAATGCTGTTGCCTGTTATGTTGCTAGGTTCTGGAATGCCAGG...
TTGACCACTGTGGGAGGACCTGGTGGGTTGACGGGCTCTCTACATTTAATGAGTCTTGAGATGCCACTTGCAGGTCCAACTCCTGCAGCATTTTCAGCCATGACATGGAATTCATACTCATTGCCTTCTGTCAGACCAGTGACTTTGAATCTTGTTTCAGAGATTGGTCGTTTGCTGATCACTTTTACCCATCTTGTGCTTTTCTTTTCTCTTCTTTCAAGGATATACTGTTGAATTTCACTGCCACCATCTGATTCTGGCCTTGCCCATGTCAGGGTAATGCTGTTGCCTGTTATGTTGCTAGGTTCTGGAATGCCAGG...
pathogenic
47,912
The mutation in gene TTN at chromosome 2, position 178551707—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTGCCGTTTATTAGTTTAATGGCAGTGTAACTTTGGGCTTCACATTTATCCTCAATTAGTGCCCAGGCAAGTCTGCTGGTTTCCCGTTTTTCAATGATGTAGTGGGTTATGGGAGCACAACCGTCATTGAGTGGGGCATCCCACCACAGAGTCATCTTCTCCCCAGTAATATTGGTGAATCTTATTGGCCCAACTACTTTTCCTGGTGTATCTATAAGAAAAAGTTTCTAGAGTTAGTTTCTTTTTCCTTGTCCATTAAAATACAACTAGGCATGTCTCTAATCCAAGTTCATAAATTGTAGCATTAAGAAGCTATTTTA...
TTGCCGTTTATTAGTTTAATGGCAGTGTAACTTTGGGCTTCACATTTATCCTCAATTAGTGCCCAGGCAAGTCTGCTGGTTTCCCGTTTTTCAATGATGTAGTGGGTTATGGGAGCACAACCGTCATTGAGTGGGGCATCCCACCACAGAGTCATCTTCTCCCCAGTAATATTGGTGAATCTTATTGGCCCAACTACTTTTCCTGGTGTATCTATAAGAAAAAGTTTCTAGAGTTAGTTTCTTTTTCCTTGTCCATTAAAATACAACTAGGCATGTCTCTAATCCAAGTTCATAAATTGTAGCATTAAGAAGCTATTTTA...
pathogenic
47,919
Mutation at chromosome 2, position 178551799, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
AATGATGTAGTGGGTTATGGGAGCACAACCGTCATTGAGTGGGGCATCCCACCACAGAGTCATCTTCTCCCCAGTAATATTGGTGAATCTTATTGGCCCAACTACTTTTCCTGGTGTATCTATAAGAAAAAGTTTCTAGAGTTAGTTTCTTTTTCCTTGTCCATTAAAATACAACTAGGCATGTCTCTAATCCAAGTTCATAAATTGTAGCATTAAGAAGCTATTTTAAAAGTACCTTGTACTTTCACTTTAATTTCTGCTTTTGCAGAACCAGATGCATTTTTGGCTTCCACTGTGTATACACCACGATGGTCCCGAGT...
AATGATGTAGTGGGTTATGGGAGCACAACCGTCATTGAGTGGGGCATCCCACCACAGAGTCATCTTCTCCCCAGTAATATTGGTGAATCTTATTGGCCCAACTACTTTTCCTGGTGTATCTATAAGAAAAAGTTTCTAGAGTTAGTTTCTTTTTCCTTGTCCATTAAAATACAACTAGGCATGTCTCTAATCCAAGTTCATAAATTGTAGCATTAAGAAGCTATTTTAAAAGTACCTTGTACTTTCACTTTAATTTCTGCTTTTGCAGAACCAGATGCATTTTTGGCTTCCACTGTGTATACACCACGATGGTCCCGAGT...
pathogenic
47,922
Clinically, how would you classify the variant at chromosome 2, position 178552242, gene TTN: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGCTTTAATTCTAAGGCTCTCTCCGGACTTAATAATGAGACCATCAAAGTATTCAGGGCCAAACTCTACTATTGGTGGAACTATAAAAGAAAGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGT...
AGCTTTAATTCTAAGGCTCTCTCCGGACTTAATAATGAGACCATCAAAGTATTCAGGGCCAAACTCTACTATTGGTGGAACTATAAAAGAAAGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGT...
pathogenic
47,941
Is the genetic variant on chromosome 2, position 178552245, gene TTN, benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TTTAATTCTAAGGCTCTCTCCGGACTTAATAATGAGACCATCAAAGTATTCAGGGCCAAACTCTACTATTGGTGGAACTATAAAAGAAAGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGTAAA...
TTTAATTCTAAGGCTCTCTCCGGACTTAATAATGAGACCATCAAAGTATTCAGGGCCAAACTCTACTATTGGTGGAACTATAAAAGAAAGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGTAAA...
pathogenic
47,942
Variant at chromosome 2, position 178552271, gene TTN: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TAATAATGAGACCATCAAAGTATTCAGGGCCAAACTCTACTATTGGTGGAACTATAAAAGAAAGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGTAAAAAGGAAAGTGAAACATTTACAGATCA...
TAATAATGAGACCATCAAAGTATTCAGGGCCAAACTCTACTATTGGTGGAACTATAAAAGAAAGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGTAAAAAGGAAAGTGAAACATTTACAGATCA...
pathogenic
47,946
Does the variant impacting TTN on chromosome 2, position 178552312, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
ATTGGTGGAACTATAAAAGAAAGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGTAAAAAGGAAAGTGAAACATTTACAGATCATGTACTTCCTAATACTGCTGCACAGTCACACAAGTTCTTTT...
ATTGGTGGAACTATAAAAGAAAGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGTAAAAAGGAAAGTGAAACATTTACAGATCATGTACTTCCTAATACTGCTGCACAGTCACACAAGTTCTTTT...
pathogenic
47,947
Variant on chromosome 2, at position 178552333, affecting TTN: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGTAAAAAGGAAAGTGAAACATTTACAGATCATGTACTTCCTAATACTGCTGCACAGTCACACAAGTTCTTTTAAGAGGCCATCAGCTGCATTC...
AGAGAAATACTATGTATTAGTTTGGCTTAATAAAGACATACATAAATATATATTTTTCAGTAGTGCCATATCACAAGGCCAGGAAGAGTAGTGACTTCTACTGTGCTACCAAAGCCTATTTTGAAAGTAGGATTGATAATTGAGAATTTGGACTATGGGGTTAAATATTTGCCTATTATTATTCCCTTTGTAATGCCTGTCATGTTTTTAATTTTGCATTGCTCTTTGTAAAAAGGAAAGTGAAACATTTACAGATCATGTACTTCCTAATACTGCTGCACAGTCACACAAGTTCTTTTAAGAGGCCATCAGCTGCATTC...
pathogenic
47,948
Considering the variant on chromosome 2, location 178552643, involving gene TTN, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
AGCTGCATTCAAGCAAGGGGATGATTGTGTTGTTGGATGTATGTTGTATTTTAATAACTTCAGTAAAGATGGACACTTATTCTCGAGAACCTTTTCTTTATGTACTGTTAAGTGGCGAAAATTACAAAGCTAAAAACTCATTCCCACTTGCTGCATGCTCTTTATATGGGAATGGAGTGAAATAATAGAAAAAATAATTGATGCCAATTATTTTTTTCTTCTTTTCATCTGAAAGGTAGAAAGACATAATTCATCCACTTAGCAACCTTGGGTAATTTGTTTCTGTTACCATTTTACAGGCCAGGGGCCAAATGTGTTTT...
AGCTGCATTCAAGCAAGGGGATGATTGTGTTGTTGGATGTATGTTGTATTTTAATAACTTCAGTAAAGATGGACACTTATTCTCGAGAACCTTTTCTTTATGTACTGTTAAGTGGCGAAAATTACAAAGCTAAAAACTCATTCCCACTTGCTGCATGCTCTTTATATGGGAATGGAGTGAAATAATAGAAAAAATAATTGATGCCAATTATTTTTTTCTTCTTTTCATCTGAAAGGTAGAAAGACATAATTCATCCACTTAGCAACCTTGGGTAATTTGTTTCTGTTACCATTTTACAGGCCAGGGGCCAAATGTGTTTT...
pathogenic
47,954
Considering the genetic mutation at chromosome 2, position 178552814, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ATGGAGTGAAATAATAGAAAAAATAATTGATGCCAATTATTTTTTTCTTCTTTTCATCTGAAAGGTAGAAAGACATAATTCATCCACTTAGCAACCTTGGGTAATTTGTTTCTGTTACCATTTTACAGGCCAGGGGCCAAATGTGTTTTTTAAAAATGTGAATGCTCTTAGTCTCATTGGAAATAAGTTGTAAATGCTTACCATTTTCATCTCTTGTCATAATAATGCCAGAAGACTGTGAGGGCGGGCTTATAGTTCCAACAGCATTTCTTGCAATTATTCTGAACTCATAGCGATCCCCAGGACTGAGTCCTGTAACT...
ATGGAGTGAAATAATAGAAAAAATAATTGATGCCAATTATTTTTTTCTTCTTTTCATCTGAAAGGTAGAAAGACATAATTCATCCACTTAGCAACCTTGGGTAATTTGTTTCTGTTACCATTTTACAGGCCAGGGGCCAAATGTGTTTTTTAAAAATGTGAATGCTCTTAGTCTCATTGGAAATAAGTTGTAAATGCTTACCATTTTCATCTCTTGTCATAATAATGCCAGAAGACTGTGAGGGCGGGCTTATAGTTCCAACAGCATTTCTTGCAATTATTCTGAACTCATAGCGATCCCCAGGACTGAGTCCTGTAACT...
pathogenic
47,963
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 2, position 178552978, gene TTN. What disease(s) is it linked to if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTCTTAGTCTCATTGGAAATAAGTTGTAAATGCTTACCATTTTCATCTCTTGTCATAATAATGCCAGAAGACTGTGAGGGCGGGCTTATAGTTCCAACAGCATTTCTTGCAATTATTCTGAACTCATAGCGATCCCCAGGACTGAGTCCTGTAACTGTGTACTGACATTCACTGACGTCAGTAAAGTTGCATCTCACCCAGCGTTCATTTCCTTGCCGTTTCTCAATGCTATAGCCCACAATCTTACTGCCTCCATCACGCAATGGTGGGTTCCATTTAAGTGTGATGGTTTCCCGGGTGACATCAATGTAGTCAGGAGT...
CTCTTAGTCTCATTGGAAATAAGTTGTAAATGCTTACCATTTTCATCTCTTGTCATAATAATGCCAGAAGACTGTGAGGGCGGGCTTATAGTTCCAACAGCATTTCTTGCAATTATTCTGAACTCATAGCGATCCCCAGGACTGAGTCCTGTAACTGTGTACTGACATTCACTGACGTCAGTAAAGTTGCATCTCACCCAGCGTTCATTTCCTTGCCGTTTCTCAATGCTATAGCCCACAATCTTACTGCCTCCATCACGCAATGGTGGGTTCCATTTAAGTGTGATGGTTTCCCGGGTGACATCAATGTAGTCAGGAGT...
pathogenic
47,970
Regarding the variant at chromosome 2 and position 178552996, affecting gene TTN: benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Primary_dilated_cardiomyopathy', 'Tibial_mu...
ATAAGTTGTAAATGCTTACCATTTTCATCTCTTGTCATAATAATGCCAGAAGACTGTGAGGGCGGGCTTATAGTTCCAACAGCATTTCTTGCAATTATTCTGAACTCATAGCGATCCCCAGGACTGAGTCCTGTAACTGTGTACTGACATTCACTGACGTCAGTAAAGTTGCATCTCACCCAGCGTTCATTTCCTTGCCGTTTCTCAATGCTATAGCCCACAATCTTACTGCCTCCATCACGCAATGGTGGGTTCCATTTAAGTGTGATGGTTTCCCGGGTGACATCAATGTAGTCAGGAGTGCCAGGTGGGTCTAAAAA...
ATAAGTTGTAAATGCTTACCATTTTCATCTCTTGTCATAATAATGCCAGAAGACTGTGAGGGCGGGCTTATAGTTCCAACAGCATTTCTTGCAATTATTCTGAACTCATAGCGATCCCCAGGACTGAGTCCTGTAACTGTGTACTGACATTCACTGACGTCAGTAAAGTTGCATCTCACCCAGCGTTCATTTCCTTGCCGTTTCTCAATGCTATAGCCCACAATCTTACTGCCTCCATCACGCAATGGTGGGTTCCATTTAAGTGTGATGGTTTCCCGGGTGACATCAATGTAGTCAGGAGTGCCAGGTGGGTCTAAAAA...
pathogenic
47,972
Variant on chromosome 2, at position 178553346, affecting TTN: is it benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TTGTAACCAGGTCTTAATCATCCATGGAAGAACAATACAATTATTCTATAATTTTAATAAATAAGTAAAATTTTTATAATAAGTAATTTATTCAATCTCCCAAACTCATATTGGTCATTAATTTCAACTTTCCATTTCATAGTCTTTAAAATGAACTTCAAATTAGTTTATTAGACTGACTTAAAATAATTCCTCTTGCTTTACATGACCAGTTCTCTAGTGACAAGAAGATATGTAAGAAGGTGATGCAGAGAAGAAAAGCATTCCTTGATATATTTGTTTCTAATATGTTCAATTGCTAAACTAAATGTATTTGAATA...
TTGTAACCAGGTCTTAATCATCCATGGAAGAACAATACAATTATTCTATAATTTTAATAAATAAGTAAAATTTTTATAATAAGTAATTTATTCAATCTCCCAAACTCATATTGGTCATTAATTTCAACTTTCCATTTCATAGTCTTTAAAATGAACTTCAAATTAGTTTATTAGACTGACTTAAAATAATTCCTCTTGCTTTACATGACCAGTTCTCTAGTGACAAGAAGATATGTAAGAAGGTGATGCAGAGAAGAAAAGCATTCCTTGATATATTTGTTTCTAATATGTTCAATTGCTAAACTAAATGTATTTGAATA...
pathogenic
47,988
Classify the chromosome 2 variant at position 178553716 affecting gene TTN as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Cardiovascular_phenotype']
CTAGGTGAGCTTAGGCCAGCAGAATTTTCAGCATATACACGGAATTGGTAATCCAGACCTTCTACCAGTCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTA...
CTAGGTGAGCTTAGGCCAGCAGAATTTTCAGCATATACACGGAATTGGTAATCCAGACCTTCTACCAGTCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTA...
pathogenic
47,996
The chromosome 2, position 178553726 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTAGGCCAGCAGAATTTTCAGCATATACACGGAATTGGTAATCCAGACCTTCTACCAGTCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCT...
TTAGGCCAGCAGAATTTTCAGCATATACACGGAATTGGTAATCCAGACCTTCTACCAGTCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCT...
pathogenic
47,999
Is the chromosome 2, position 178553734 variant in TTN clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GCAGAATTTTCAGCATATACACGGAATTGGTAATCCAGACCTTCTACCAGTCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCTGCTCTCAC...
GCAGAATTTTCAGCATATACACGGAATTGGTAATCCAGACCTTCTACCAGTCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCTGCTCTCAC...
pathogenic
48,000
A genetic variant on chromosome 2, position 178553778, affects the gene TTN. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TACCAGTCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCTGCTCTCACTCTAAACTGGTACTCAGCATCTTTGACTAGATTAGGAACTTTGA...
TACCAGTCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCTGCTCTCACTCTAAACTGGTACTCAGCATCTTTGACTAGATTAGGAACTTTGA...
pathogenic
48,004
Is the genetic change at chromosome 2, position 178553784, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'TTN-related_disorder']
TCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCTGCTCTCACTCTAAACTGGTACTCAGCATCTTTGACTAGATTAGGAACTTTGAAAGTCG...
TCCAGTGGCTCTATATTCTCTTCCAGAGATTGGTGATGTATTAACTTTTTGCCAGAGGATGCTATTTCTTTCTTTCTTTTCAACATGGAATCCAGTAACTTCTGAACCACCATCATAAACTGGAGCATCCCAAGTTAGTGACATGCCATCAGAAGTCACATTGTATATAACTGGCTTTCCTGGGGGACCAGGAATCCTGAACTGGTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCTGCTCTCACTCTAAACTGGTACTCAGCATCTTTGACTAGATTAGGAACTTTGAAAGTCG...
pathogenic
48,005
Determine whether the variant at chromosome 2, position 178553988, in gene TTN is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCTGCTCTCACTCTAAACTGGTACTCAGCATCTTTGACTAGATTAGGAACTTTGAAAGTCGTTCTGGCAACACTTGAACACACCATCTTCCAGTTAGTTTGTGAAGTTTCCCGCTTCTCGATGCTGTAACAAGTAATTTCTCCTCCTCCATTATCTTCAGGTACATCCCATGACAGGATGACACTATCAGCCTTGATTTCATCAAATCGAATGGGTCCTTTGGGCTTTGATGGTGGGCCAAGGGTGATGACTGTAATGGGGACTG...
GTGTTTTGCCACAATAATGCTTGAGACAAGTGGTTGGCTGACTCCGTATCTGTTTTCTGCTCTCACTCTAAACTGGTACTCAGCATCTTTGACTAGATTAGGAACTTTGAAAGTCGTTCTGGCAACACTTGAACACACCATCTTCCAGTTAGTTTGTGAAGTTTCCCGCTTCTCGATGCTGTAACAAGTAATTTCTCCTCCTCCATTATCTTCAGGTACATCCCATGACAGGATGACACTATCAGCCTTGATTTCATCAAATCGAATGGGTCCTTTGGGCTTTGATGGTGGGCCAAGGGTGATGACTGTAATGGGGACTG...
pathogenic
48,011
Does the genetic variant at chromosome 2, position 178554104, impacting gene TTN, appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TTCTGGCAACACTTGAACACACCATCTTCCAGTTAGTTTGTGAAGTTTCCCGCTTCTCGATGCTGTAACAAGTAATTTCTCCTCCTCCATTATCTTCAGGTACATCCCATGACAGGATGACACTATCAGCCTTGATTTCATCAAATCGAATGGGTCCTTTGGGCTTTGATGGTGGGCCAAGGGTGATGACTGTAATGGGGACTGCAATTCTACACACTGCATTATCAAGAATAACAGTGTATTTTCCTCCATGCTCCTTCTTGGCATTCTTAATACTCAAAGTAATTTTGTTTTCAGTTTTACTGAAGCGAACAAATTCA...
TTCTGGCAACACTTGAACACACCATCTTCCAGTTAGTTTGTGAAGTTTCCCGCTTCTCGATGCTGTAACAAGTAATTTCTCCTCCTCCATTATCTTCAGGTACATCCCATGACAGGATGACACTATCAGCCTTGATTTCATCAAATCGAATGGGTCCTTTGGGCTTTGATGGTGGGCCAAGGGTGATGACTGTAATGGGGACTGCAATTCTACACACTGCATTATCAAGAATAACAGTGTATTTTCCTCCATGCTCCTTCTTGGCATTCTTAATACTCAAAGTAATTTTGTTTTCAGTTTTACTGAAGCGAACAAATTCA...
pathogenic
48,016
The mutation in gene TTN at chromosome 2, position 178554125—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CCATCTTCCAGTTAGTTTGTGAAGTTTCCCGCTTCTCGATGCTGTAACAAGTAATTTCTCCTCCTCCATTATCTTCAGGTACATCCCATGACAGGATGACACTATCAGCCTTGATTTCATCAAATCGAATGGGTCCTTTGGGCTTTGATGGTGGGCCAAGGGTGATGACTGTAATGGGGACTGCAATTCTACACACTGCATTATCAAGAATAACAGTGTATTTTCCTCCATGCTCCTTCTTGGCATTCTTAATACTCAAAGTAATTTTGTTTTCAGTTTTACTGAAGCGAACAAATTCACTTTCTTTCAGTGGCAAGCCA...
CCATCTTCCAGTTAGTTTGTGAAGTTTCCCGCTTCTCGATGCTGTAACAAGTAATTTCTCCTCCTCCATTATCTTCAGGTACATCCCATGACAGGATGACACTATCAGCCTTGATTTCATCAAATCGAATGGGTCCTTTGGGCTTTGATGGTGGGCCAAGGGTGATGACTGTAATGGGGACTGCAATTCTACACACTGCATTATCAAGAATAACAGTGTATTTTCCTCCATGCTCCTTCTTGGCATTCTTAATACTCAAAGTAATTTTGTTTTCAGTTTTACTGAAGCGAACAAATTCACTTTCTTTCAGTGGCAAGCCA...
pathogenic
48,017
Is the variant located on chromosome 2 at position 178554491, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ATTCAAGGTGCACATTGTGCCCAATTCTCACAGTGACTTGTGCCCCAGGGATATCTGACAGGTCAACTTCAGGTGTAATAATAAGTTCTTTCACTGTAATTGGCCCAATAGTGACAGGATCACTCAGTCCTTTCTCATTTTTGGCAAACACTCTGAACTCCAGGACTGACTGCTCCTTAAGTTGGCTAACCTCAATTTCACATGTCTTACTTATGCCAGCGTGGGACCACGTCTGTTCACCTTTACCTTTCCTTTCTACAACATATTCTGTGATGACGCTACCACCATCAAAGTCAGGTTTGGTCCAGCTGAGGATGACA...
ATTCAAGGTGCACATTGTGCCCAATTCTCACAGTGACTTGTGCCCCAGGGATATCTGACAGGTCAACTTCAGGTGTAATAATAAGTTCTTTCACTGTAATTGGCCCAATAGTGACAGGATCACTCAGTCCTTTCTCATTTTTGGCAAACACTCTGAACTCCAGGACTGACTGCTCCTTAAGTTGGCTAACCTCAATTTCACATGTCTTACTTATGCCAGCGTGGGACCACGTCTGTTCACCTTTACCTTTCCTTTCTACAACATATTCTGTGATGACGCTACCACCATCAAAGTCAGGTTTGGTCCAGCTGAGGATGACA...
pathogenic
48,026
Is the genetic mutation found on chromosome 2 at position 178554642, within the gene TTN, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TCTGAACTCCAGGACTGACTGCTCCTTAAGTTGGCTAACCTCAATTTCACATGTCTTACTTATGCCAGCGTGGGACCACGTCTGTTCACCTTTACCTTTCCTTTCTACAACATATTCTGTGATGACGCTACCACCATCAAAGTCAGGTTTGGTCCAGCTGAGGATGACAGATGTCTTTGTTGAGTCTTTCATTGAGAGATCACGTATAGGAGCTGGTACTTCAGCAGCCTTCACTGGCTCTGTAGTTTCACAGGGTTCCCCAATTCCAATTTCATTTTCTGCAAGAACTCTGAAGAAGAATGGAGTCTTCTCCGACAAAT...
TCTGAACTCCAGGACTGACTGCTCCTTAAGTTGGCTAACCTCAATTTCACATGTCTTACTTATGCCAGCGTGGGACCACGTCTGTTCACCTTTACCTTTCCTTTCTACAACATATTCTGTGATGACGCTACCACCATCAAAGTCAGGTTTGGTCCAGCTGAGGATGACAGATGTCTTTGTTGAGTCTTTCATTGAGAGATCACGTATAGGAGCTGGTACTTCAGCAGCCTTCACTGGCTCTGTAGTTTCACAGGGTTCCCCAATTCCAATTTCATTTTCTGCAAGAACTCTGAAGAAGAATGGAGTCTTCTCCGACAAAT...
pathogenic
48,039
Classify the chromosome 2 variant at position 178554650 affecting gene TTN as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CCAGGACTGACTGCTCCTTAAGTTGGCTAACCTCAATTTCACATGTCTTACTTATGCCAGCGTGGGACCACGTCTGTTCACCTTTACCTTTCCTTTCTACAACATATTCTGTGATGACGCTACCACCATCAAAGTCAGGTTTGGTCCAGCTGAGGATGACAGATGTCTTTGTTGAGTCTTTCATTGAGAGATCACGTATAGGAGCTGGTACTTCAGCAGCCTTCACTGGCTCTGTAGTTTCACAGGGTTCCCCAATTCCAATTTCATTTTCTGCAAGAACTCTGAAGAAGAATGGAGTCTTCTCCGACAAATCTATTAGC...
CCAGGACTGACTGCTCCTTAAGTTGGCTAACCTCAATTTCACATGTCTTACTTATGCCAGCGTGGGACCACGTCTGTTCACCTTTACCTTTCCTTTCTACAACATATTCTGTGATGACGCTACCACCATCAAAGTCAGGTTTGGTCCAGCTGAGGATGACAGATGTCTTTGTTGAGTCTTTCATTGAGAGATCACGTATAGGAGCTGGTACTTCAGCAGCCTTCACTGGCTCTGTAGTTTCACAGGGTTCCCCAATTCCAATTTCATTTTCTGCAAGAACTCTGAAGAAGAATGGAGTCTTCTCCGACAAATCTATTAGC...
pathogenic
48,041
Clinically, how would you classify the variant at chromosome 2, position 178557059, gene TTN: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GTTTGTAATTCTTTATCATCTTTATACCACTCAATAGTAGGCGCAGGTTTGCCAGAAATGCCAGCTCTGAGCTTCACAGATGTACCTGCTCTGTATTTGACAACTTCTGTATATTCTAGAGGCAAATCAATTACAGGACCACCTGCAAGAAAAACAGATGAGAAATATTTAAAATATTATAAGGATGGAAAAAAAAATAGTTGCACCAACCTTAAAGTAAGGTCATTGGCCATTATTAAATTATACACACACACCATCATTATAATTCTATGCAATTATTATTTAAAAATTAAAAATTTATAGGCCACTCTTCTATCTCA...
GTTTGTAATTCTTTATCATCTTTATACCACTCAATAGTAGGCGCAGGTTTGCCAGAAATGCCAGCTCTGAGCTTCACAGATGTACCTGCTCTGTATTTGACAACTTCTGTATATTCTAGAGGCAAATCAATTACAGGACCACCTGCAAGAAAAACAGATGAGAAATATTTAAAATATTATAAGGATGGAAAAAAAAATAGTTGCACCAACCTTAAAGTAAGGTCATTGGCCATTATTAAATTATACACACACACCATCATTATAATTCTATGCAATTATTATTTAAAAATTAAAAATTTATAGGCCACTCTTCTATCTCA...
pathogenic
48,072
Evaluate this variant at chromosome 2, position 178557261, gene TTN: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GCACCAACCTTAAAGTAAGGTCATTGGCCATTATTAAATTATACACACACACCATCATTATAATTCTATGCAATTATTATTTAAAAATTAAAAATTTATAGGCCACTCTTCTATCTCAGATGGGGTAGAAAGACTGTGAGTTGTGCAGGGACTTAAGCACCTTTTACATGTGTTTTAAAGTCCATTAGTTGCTTTATTCCAGTGAAGAAATGGGATATGGTAGTGAGAACATCATGGAAGAAGCTGTTAAAACATTTCCTTTCACTTTAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCAT...
GCACCAACCTTAAAGTAAGGTCATTGGCCATTATTAAATTATACACACACACCATCATTATAATTCTATGCAATTATTATTTAAAAATTAAAAATTTATAGGCCACTCTTCTATCTCAGATGGGGTAGAAAGACTGTGAGTTGTGCAGGGACTTAAGCACCTTTTACATGTGTTTTAAAGTCCATTAGTTGCTTTATTCCAGTGAAGAAATGGGATATGGTAGTGAGAACATCATGGAAGAAGCTGTTAAAACATTTCCTTTCACTTTAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCAT...
pathogenic
48,080
Does the chromosome 2 mutation at position 178557413 within gene TTN classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Primary_dilated_cardiomyopathy']
TTAAGCACCTTTTACATGTGTTTTAAAGTCCATTAGTTGCTTTATTCCAGTGAAGAAATGGGATATGGTAGTGAGAACATCATGGAAGAAGCTGTTAAAACATTTCCTTTCACTTTAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATAC...
TTAAGCACCTTTTACATGTGTTTTAAAGTCCATTAGTTGCTTTATTCCAGTGAAGAAATGGGATATGGTAGTGAGAACATCATGGAAGAAGCTGTTAAAACATTTCCTTTCACTTTAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATAC...
pathogenic
48,085
Does the chromosome 2 mutation at position 178557424 within gene TTN classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTACATGTGTTTTAAAGTCCATTAGTTGCTTTATTCCAGTGAAGAAATGGGATATGGTAGTGAGAACATCATGGAAGAAGCTGTTAAAACATTTCCTTTCACTTTAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATACTCTCATAAACA...
TTACATGTGTTTTAAAGTCCATTAGTTGCTTTATTCCAGTGAAGAAATGGGATATGGTAGTGAGAACATCATGGAAGAAGCTGTTAAAACATTTCCTTTCACTTTAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATACTCTCATAAACA...
pathogenic
48,086
A genetic alteration at chromosome 2, position 178557426, in gene TTN—benign or pathogenic? If pathogenic, which disease(s) is involved?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ACATGTGTTTTAAAGTCCATTAGTTGCTTTATTCCAGTGAAGAAATGGGATATGGTAGTGAGAACATCATGGAAGAAGCTGTTAAAACATTTCCTTTCACTTTAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATACTCTCATAAACACT...
ACATGTGTTTTAAAGTCCATTAGTTGCTTTATTCCAGTGAAGAAATGGGATATGGTAGTGAGAACATCATGGAAGAAGCTGTTAAAACATTTCCTTTCACTTTAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATACTCTCATAAACACT...
pathogenic
48,088
Mutation found at chromosome 2 position 178557528, gene TTN: benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATACTCTCATAAACACTGATTCAGTATCCACAAAGCCTGATTCATAAATAATGAACAGCCCTGAGATTCTCAGCATGAAGATGGAAGTGGATACTTTTGCCCAGACACTACAGTGGCTC...
TAGCTTTTCTTTCCTTTTCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATACTCTCATAAACACTGATTCAGTATCCACAAAGCCTGATTCATAAATAATGAACAGCCCTGAGATTCTCAGCATGAAGATGGAAGTGGATACTTTTGCCCAGACACTACAGTGGCTC...
pathogenic
48,094
Evaluate if the mutation on chromosome 2 at position 178557545 in TTN is benign or pathogenic. Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
TCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATACTCTCATAAACACTGATTCAGTATCCACAAAGCCTGATTCATAAATAATGAACAGCCCTGAGATTCTCAGCATGAAGATGGAAGTGGATACTTTTGCCCAGACACTACAGTGGCTCAATTTTCTCTTAGCAAA...
TCTTCTACGCACCTCCTATTCTTTTTCTTTTCCCATCCCAGTTCACTGATATCCAAGTGTGGATGGTTCATGTCAGACACTTAAAGTCTGAATTCTCTACCCACAGAGCTACATAATTACTGGACAGATTTTCTGCCATGCTGTTTGGAATTATCAAGAAAGATAACTAAATTCGACTTGCTTTATACTCTCATAAACACTGATTCAGTATCCACAAAGCCTGATTCATAAATAATGAACAGCCCTGAGATTCTCAGCATGAAGATGGAAGTGGATACTTTTGCCCAGACACTACAGTGGCTCAATTTTCTCTTAGCAAA...
pathogenic
48,096
Variant at chromosome position 178557838, chromosome 2, gene TTN: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ACAGTGGCTCAATTTTCTCTTAGCAAATGGAGATCTTTTAGGTAAAGTGTCACAGGATACCTGACTCTCATGACGTTTTAATTTTCAAAACATTGTTGAGTTGAATGTGCCACTTATTTTCCAGAATGGTGAAGAATACGCATTTTGGACTAACCATGATAGAGAGGGCTCTGAAGTCTGTCTGTCTGAATTCCCACTCCATCCCTAACGGGGAAGTTACAAAAGCACTCTCAGCCTCAGTTTCCCTTCTATAAGATGGCTAATATGAGGGCTGTGAGAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTA...
ACAGTGGCTCAATTTTCTCTTAGCAAATGGAGATCTTTTAGGTAAAGTGTCACAGGATACCTGACTCTCATGACGTTTTAATTTTCAAAACATTGTTGAGTTGAATGTGCCACTTATTTTCCAGAATGGTGAAGAATACGCATTTTGGACTAACCATGATAGAGAGGGCTCTGAAGTCTGTCTGTCTGAATTCCCACTCCATCCCTAACGGGGAAGTTACAAAAGCACTCTCAGCCTCAGTTTCCCTTCTATAAGATGGCTAATATGAGGGCTGTGAGAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTA...
pathogenic
48,111
Gene TTN variant at chromosome position 178557902 on chromosome 2: benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CTCTCATGACGTTTTAATTTTCAAAACATTGTTGAGTTGAATGTGCCACTTATTTTCCAGAATGGTGAAGAATACGCATTTTGGACTAACCATGATAGAGAGGGCTCTGAAGTCTGTCTGTCTGAATTCCCACTCCATCCCTAACGGGGAAGTTACAAAAGCACTCTCAGCCTCAGTTTCCCTTCTATAAGATGGCTAATATGAGGGCTGTGAGAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTAGCTGCTGCTAATACTATCATCATCAAAGTCTGTGTTTAGACCAGGCATGGTGGCTCACACCTGT...
CTCTCATGACGTTTTAATTTTCAAAACATTGTTGAGTTGAATGTGCCACTTATTTTCCAGAATGGTGAAGAATACGCATTTTGGACTAACCATGATAGAGAGGGCTCTGAAGTCTGTCTGTCTGAATTCCCACTCCATCCCTAACGGGGAAGTTACAAAAGCACTCTCAGCCTCAGTTTCCCTTCTATAAGATGGCTAATATGAGGGCTGTGAGAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTAGCTGCTGCTAATACTATCATCATCAAAGTCTGTGTTTAGACCAGGCATGGTGGCTCACACCTGT...
pathogenic
48,113
Variant at chromosome position 178557998, chromosome 2, gene TTN: benign or pathogenic? If pathogenic, what condition(s) does it relate to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Dilated_cardiomyopathy_1S']
AGAGAGGGCTCTGAAGTCTGTCTGTCTGAATTCCCACTCCATCCCTAACGGGGAAGTTACAAAAGCACTCTCAGCCTCAGTTTCCCTTCTATAAGATGGCTAATATGAGGGCTGTGAGAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTAGCTGCTGCTAATACTATCATCATCAAAGTCTGTGTTTAGACCAGGCATGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGGTTGAGACCTGCCTGGCCAACATGGTGAAACTCCGTCCCTACTAA...
AGAGAGGGCTCTGAAGTCTGTCTGTCTGAATTCCCACTCCATCCCTAACGGGGAAGTTACAAAAGCACTCTCAGCCTCAGTTTCCCTTCTATAAGATGGCTAATATGAGGGCTGTGAGAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTAGCTGCTGCTAATACTATCATCATCAAAGTCTGTGTTTAGACCAGGCATGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGGTTGAGACCTGCCTGGCCAACATGGTGAAACTCCGTCCCTACTAA...
pathogenic
48,119
Classify the chromosome 2 variant at position 178558058 affecting gene TTN as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AAAAGCACTCTCAGCCTCAGTTTCCCTTCTATAAGATGGCTAATATGAGGGCTGTGAGAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTAGCTGCTGCTAATACTATCATCATCAAAGTCTGTGTTTAGACCAGGCATGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGGTTGAGACCTGCCTGGCCAACATGGTGAAACTCCGTCCCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGGGCATGCCTGTAATCCCAGCTACTCAGGTGA...
AAAAGCACTCTCAGCCTCAGTTTCCCTTCTATAAGATGGCTAATATGAGGGCTGTGAGAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTAGCTGCTGCTAATACTATCATCATCAAAGTCTGTGTTTAGACCAGGCATGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGGTTGAGACCTGCCTGGCCAACATGGTGAAACTCCGTCCCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGGGCATGCCTGTAATCCCAGCTACTCAGGTGA...
pathogenic
48,121
Classify the chromosome 2 variant at position 178558115 affecting gene TTN as benign or pathogenic. If pathogenic, which disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTAGCTGCTGCTAATACTATCATCATCAAAGTCTGTGTTTAGACCAGGCATGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGGTTGAGACCTGCCTGGCCAACATGGTGAAACTCCGTCCCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGGGCATGCCTGTAATCCCAGCTACTCAGGTGACTGAGGCACGAGAATCGTTTGAGCCCAGGAGGCGGAAGTTGCAGTGAACCAAGACCG...
GAACTAAGGGAAAGAATTCATGAAAATTCCTCAATAAATGTTAGCTGCTGCTAATACTATCATCATCAAAGTCTGTGTTTAGACCAGGCATGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGGTTGAGACCTGCCTGGCCAACATGGTGAAACTCCGTCCCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGGGCATGCCTGTAATCCCAGCTACTCAGGTGACTGAGGCACGAGAATCGTTTGAGCCCAGGAGGCGGAAGTTGCAGTGAACCAAGACCG...
pathogenic
48,123
For chromosome 2, position 178558409, gene TTN: benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GCGGAAGTTGCAGTGAACCAAGACCGTGCCACTGCACTACAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAACAAACAAACAAACAAACAAACAAAAAAAAAAAAACCAAAAAATGAAGTCTCTGTTTAGTCTGTGGCTTATTTAAGAGCAATATTCTCTAGGAACTCAACCATGGTTTAATTATTGACTCTGATAATTTAAAACAGAATGAAAGCACCAACTCATACAATCAATCATAAAAGGTTGAAGTTGGAAAGGCCCATAGATATCCTGAGGTCTAAATCTCTCACTTTACAGTCAAGTCAAGAGGGCTGGAA...
GCGGAAGTTGCAGTGAACCAAGACCGTGCCACTGCACTACAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAACAAACAAACAAACAAACAAACAAAAAAAAAAAAACCAAAAAATGAAGTCTCTGTTTAGTCTGTGGCTTATTTAAGAGCAATATTCTCTAGGAACTCAACCATGGTTTAATTATTGACTCTGATAATTTAAAACAGAATGAAAGCACCAACTCATACAATCAATCATAAAAGGTTGAAGTTGGAAAGGCCCATAGATATCCTGAGGTCTAAATCTCTCACTTTACAGTCAAGTCAAGAGGGCTGGAA...
pathogenic
48,130
Clinical significance of chromosome 2, position 178558436, gene TTN: benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GCCACTGCACTACAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAACAAACAAACAAACAAACAAACAAAAAAAAAAAAACCAAAAAATGAAGTCTCTGTTTAGTCTGTGGCTTATTTAAGAGCAATATTCTCTAGGAACTCAACCATGGTTTAATTATTGACTCTGATAATTTAAAACAGAATGAAAGCACCAACTCATACAATCAATCATAAAAGGTTGAAGTTGGAAAGGCCCATAGATATCCTGAGGTCTAAATCTCTCACTTTACAGTCAAGTCAAGAGGGCTGGAAAGGTATTTAAGGAATTTTCCTCAGACT...
GCCACTGCACTACAGCCTGGGCGACAGAGTGAGACTCTGTCTCAAAACAAACAAACAAACAAACAAACAAAAAAAAAAAAACCAAAAAATGAAGTCTCTGTTTAGTCTGTGGCTTATTTAAGAGCAATATTCTCTAGGAACTCAACCATGGTTTAATTATTGACTCTGATAATTTAAAACAGAATGAAAGCACCAACTCATACAATCAATCATAAAAGGTTGAAGTTGGAAAGGCCCATAGATATCCTGAGGTCTAAATCTCTCACTTTACAGTCAAGTCAAGAGGGCTGGAAAGGTATTTAAGGAATTTTCCTCAGACT...
pathogenic
48,133
Is the variant located on chromosome 2 at position 178558569, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CTAGGAACTCAACCATGGTTTAATTATTGACTCTGATAATTTAAAACAGAATGAAAGCACCAACTCATACAATCAATCATAAAAGGTTGAAGTTGGAAAGGCCCATAGATATCCTGAGGTCTAAATCTCTCACTTTACAGTCAAGTCAAGAGGGCTGGAAAGGTATTTAAGGAATTTTCCTCAGACTCCCAGCTAGTCCATAATTTCTTCCAAAAACCCCATTAAGGCACAGAGTAAAAGTTATTCTATAGGATTAGAACCAGGAAAAGGTATGCGGAAATACTGAGTTAAATAGCAATTTTGATTCAAAGTGCTAAGCA...
CTAGGAACTCAACCATGGTTTAATTATTGACTCTGATAATTTAAAACAGAATGAAAGCACCAACTCATACAATCAATCATAAAAGGTTGAAGTTGGAAAGGCCCATAGATATCCTGAGGTCTAAATCTCTCACTTTACAGTCAAGTCAAGAGGGCTGGAAAGGTATTTAAGGAATTTTCCTCAGACTCCCAGCTAGTCCATAATTTCTTCCAAAAACCCCATTAAGGCACAGAGTAAAAGTTATTCTATAGGATTAGAACCAGGAAAAGGTATGCGGAAATACTGAGTTAAATAGCAATTTTGATTCAAAGTGCTAAGCA...
pathogenic
48,144
Chromosome 2, position 178559329, gene TTN: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy', 'Primary_familial_dilated_cardiomyopathy', 'TTN-related_disorder']
AGAAGGATGGCTAGGTTTTCCAACTCCAGCAGCATTTTCTGCATACACCCTGAATTCATAAATAAGTCCAGCACTGATTGTTGTGACTTTGAAGTGAGTTGTGCGGATGACCAGTTTGTTGGCTTTTTGCCATAAAATACTGTTTCTGTCTTTCATTTCCAGGTGATAGCCTACGACTGCACTGCCTCCATTTGACACTGGTTCATGCCAGCCCACAGTGATGCTTTCTCGAGTAACATTAGTGACCCATGGTGTAGATGGTGGTCCAGGTGTTGCTACAAAAGAGAGAAATCCTATAGATTAGTACAGACAATAACACA...
AGAAGGATGGCTAGGTTTTCCAACTCCAGCAGCATTTTCTGCATACACCCTGAATTCATAAATAAGTCCAGCACTGATTGTTGTGACTTTGAAGTGAGTTGTGCGGATGACCAGTTTGTTGGCTTTTTGCCATAAAATACTGTTTCTGTCTTTCATTTCCAGGTGATAGCCTACGACTGCACTGCCTCCATTTGACACTGGTTCATGCCAGCCCACAGTGATGCTTTCTCGAGTAACATTAGTGACCCATGGTGTAGATGGTGGTCCAGGTGTTGCTACAAAAGAGAGAAATCCTATAGATTAGTACAGACAATAACACA...
pathogenic
48,150
A genetic variant at chromosome 2, position 178559690, affecting gene TTN—is it benign or pathogenic? If pathogenic, identify the associated disorder(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ACTTACTGTATGGTAGTTTGACAGTCACACAAGCTGAATCTATATGATCACTGATGCCAAAGCGGTTTTCTGCCTTGATGCGGAATTGGTATTCTTCTCCTGTGGTCAGTTTCATGACTTTCATCATGGTTCTTGCAACTGTTGCAGACACTTCAGTCCACACTGCAGTACTTGTTTCTCTTTTGAGTAGAATGTAGTTGGTAACTTGACTTCCACCGTCATACTTAGGTGGCTCCCATTTGAGAGTCACACTTTCTTCAGTTATATCACTAATAACAACAGGGCCAGTTGGAGGACCAGGCCTGTCTAGCACAACAATG...
ACTTACTGTATGGTAGTTTGACAGTCACACAAGCTGAATCTATATGATCACTGATGCCAAAGCGGTTTTCTGCCTTGATGCGGAATTGGTATTCTTCTCCTGTGGTCAGTTTCATGACTTTCATCATGGTTCTTGCAACTGTTGCAGACACTTCAGTCCACACTGCAGTACTTGTTTCTCTTTTGAGTAGAATGTAGTTGGTAACTTGACTTCCACCGTCATACTTAGGTGGCTCCCATTTGAGAGTCACACTTTCTTCAGTTATATCACTAATAACAACAGGGCCAGTTGGAGGACCAGGCCTGTCTAGCACAACAATG...
pathogenic
48,167
Regarding the variant at chromosome 2 and position 178559740, affecting gene TTN: benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy...
CTGATGCCAAAGCGGTTTTCTGCCTTGATGCGGAATTGGTATTCTTCTCCTGTGGTCAGTTTCATGACTTTCATCATGGTTCTTGCAACTGTTGCAGACACTTCAGTCCACACTGCAGTACTTGTTTCTCTTTTGAGTAGAATGTAGTTGGTAACTTGACTTCCACCGTCATACTTAGGTGGCTCCCATTTGAGAGTCACACTTTCTTCAGTTATATCACTAATAACAACAGGGCCAGTTGGAGGACCAGGCCTGTCTAGCACAACAATGTTAATGAAAGCTTTGGTTGTACCACTGGAGTTGGCAGCAGTGATTTCATA...
CTGATGCCAAAGCGGTTTTCTGCCTTGATGCGGAATTGGTATTCTTCTCCTGTGGTCAGTTTCATGACTTTCATCATGGTTCTTGCAACTGTTGCAGACACTTCAGTCCACACTGCAGTACTTGTTTCTCTTTTGAGTAGAATGTAGTTGGTAACTTGACTTCCACCGTCATACTTAGGTGGCTCCCATTTGAGAGTCACACTTTCTTCAGTTATATCACTAATAACAACAGGGCCAGTTGGAGGACCAGGCCTGTCTAGCACAACAATGTTAATGAAAGCTTTGGTTGTACCACTGGAGTTGGCAGCAGTGATTTCATA...
pathogenic
48,174
Clinical significance of chromosome 2, position 178559829, gene TTN: benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G']
TGTTGCAGACACTTCAGTCCACACTGCAGTACTTGTTTCTCTTTTGAGTAGAATGTAGTTGGTAACTTGACTTCCACCGTCATACTTAGGTGGCTCCCATTTGAGAGTCACACTTTCTTCAGTTATATCACTAATAACAACAGGGCCAGTTGGAGGACCAGGCCTGTCTAGCACAACAATGTTAATGAAAGCTTTGGTTGTACCACTGGAGTTGGCAGCAGTGATTTCATATCTCCCAGCGTCAGCTGTAACACTTTCTTTGAGATTGATGGTCAGGTTCTCAGCAGTAATTTCGGTATTAAATCTCATGGTTGCCTTAA...
TGTTGCAGACACTTCAGTCCACACTGCAGTACTTGTTTCTCTTTTGAGTAGAATGTAGTTGGTAACTTGACTTCCACCGTCATACTTAGGTGGCTCCCATTTGAGAGTCACACTTTCTTCAGTTATATCACTAATAACAACAGGGCCAGTTGGAGGACCAGGCCTGTCTAGCACAACAATGTTAATGAAAGCTTTGGTTGTACCACTGGAGTTGGCAGCAGTGATTTCATATCTCCCAGCGTCAGCTGTAACACTTTCTTTGAGATTGATGGTCAGGTTCTCAGCAGTAATTTCGGTATTAAATCTCATGGTTGCCTTAA...
pathogenic
48,177
The genetic variant at chromosome 2, position 178559863, affecting gene TTN: benign or pathogenic? Disease name(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GTTTCTCTTTTGAGTAGAATGTAGTTGGTAACTTGACTTCCACCGTCATACTTAGGTGGCTCCCATTTGAGAGTCACACTTTCTTCAGTTATATCACTAATAACAACAGGGCCAGTTGGAGGACCAGGCCTGTCTAGCACAACAATGTTAATGAAAGCTTTGGTTGTACCACTGGAGTTGGCAGCAGTGATTTCATATCTCCCAGCGTCAGCTGTAACACTTTCTTTGAGATTGATGGTCAGGTTCTCAGCAGTAATTTCGGTATTAAATCTCATGGTTGCCTTAAGGGGGACACCATCTCTTGATAAGGTCACTTTGGG...
GTTTCTCTTTTGAGTAGAATGTAGTTGGTAACTTGACTTCCACCGTCATACTTAGGTGGCTCCCATTTGAGAGTCACACTTTCTTCAGTTATATCACTAATAACAACAGGGCCAGTTGGAGGACCAGGCCTGTCTAGCACAACAATGTTAATGAAAGCTTTGGTTGTACCACTGGAGTTGGCAGCAGTGATTTCATATCTCCCAGCGTCAGCTGTAACACTTTCTTTGAGATTGATGGTCAGGTTCTCAGCAGTAATTTCGGTATTAAATCTCATGGTTGCCTTAAGGGGGACACCATCTCTTGATAAGGTCACTTTGGG...
pathogenic
48,180
The chromosome 2, position 178560055 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TCATATCTCCCAGCGTCAGCTGTAACACTTTCTTTGAGATTGATGGTCAGGTTCTCAGCAGTAATTTCGGTATTAAATCTCATGGTTGCCTTAAGGGGGACACCATCTCTTGATAAGGTCACTTTGGGAAGTGGTTTTCCAGAGATTGGAATGTCAACTTTAAGGTTTGAACCAGCTCTAACATATACAGTGTGACTTGGGAAATTCTTCATATCAATTTCAGGTGGTTCTGAAAAATGAGTATAGAAAGTGAAAGTGAAAAAGTGTTTCTGAAAATTAACATAAATCAATGCAAATAATTTCAAATTTTGCTTCTACAC...
TCATATCTCCCAGCGTCAGCTGTAACACTTTCTTTGAGATTGATGGTCAGGTTCTCAGCAGTAATTTCGGTATTAAATCTCATGGTTGCCTTAAGGGGGACACCATCTCTTGATAAGGTCACTTTGGGAAGTGGTTTTCCAGAGATTGGAATGTCAACTTTAAGGTTTGAACCAGCTCTAACATATACAGTGTGACTTGGGAAATTCTTCATATCAATTTCAGGTGGTTCTGAAAAATGAGTATAGAAAGTGAAAGTGAAAAAGTGTTTCTGAAAATTAACATAAATCAATGCAAATAATTTCAAATTTTGCTTCTACAC...
pathogenic
48,189
Is chromosome 2, position 178560423, gene TTN variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CTCTCTCGGGTCACTCAGGCCAGCTTGATTTTCAGCAAACACTCGGAAAAAGTATTCAGAATTCTCTCTCAGACCGGAAACAACGTGATGGGTTGACTTTGCCACTGCACATTTAACCCAGTTTTTCTGTCCTTTTTCTAGTGCTTCAACGACATAGTGTACAATTCTGCTTCCGCCATCATGTTCAGGCTTCAGCCAGGTCAGGGAAACACTGTCTTTGGATATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTG...
CTCTCTCGGGTCACTCAGGCCAGCTTGATTTTCAGCAAACACTCGGAAAAAGTATTCAGAATTCTCTCTCAGACCGGAAACAACGTGATGGGTTGACTTTGCCACTGCACATTTAACCCAGTTTTTCTGTCCTTTTTCTAGTGCTTCAACGACATAGTGTACAATTCTGCTTCCGCCATCATGTTCAGGCTTCAGCCAGGTCAGGGAAACACTGTCTTTGGATATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTG...
pathogenic
48,205
Determine whether the variant at chromosome 2, position 178560479, in gene TTN is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CAGAATTCTCTCTCAGACCGGAAACAACGTGATGGGTTGACTTTGCCACTGCACATTTAACCCAGTTTTTCTGTCCTTTTTCTAGTGCTTCAACGACATAGTGTACAATTCTGCTTCCGCCATCATGTTCAGGCTTCAGCCAGGTCAGGGAAACACTGTCTTTGGATATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTT...
CAGAATTCTCTCTCAGACCGGAAACAACGTGATGGGTTGACTTTGCCACTGCACATTTAACCCAGTTTTTCTGTCCTTTTTCTAGTGCTTCAACGACATAGTGTACAATTCTGCTTCCGCCATCATGTTCAGGCTTCAGCCAGGTCAGGGAAACACTGTCTTTGGATATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTT...
pathogenic
48,209
For chromosome 2, position 178560512, gene TTN: benign or pathogenic mutation? If pathogenic, what are the associated disease(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_familial_dilated_cardiomyopathy']
GGGTTGACTTTGCCACTGCACATTTAACCCAGTTTTTCTGTCCTTTTTCTAGTGCTTCAACGACATAGTGTACAATTCTGCTTCCGCCATCATGTTCAGGCTTCAGCCAGGTCAGGGAAACACTGTCTTTGGATATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTTGATTTTAGTCTTCCTTTTTACATAACCCATTTT...
GGGTTGACTTTGCCACTGCACATTTAACCCAGTTTTTCTGTCCTTTTTCTAGTGCTTCAACGACATAGTGTACAATTCTGCTTCCGCCATCATGTTCAGGCTTCAGCCAGGTCAGGGAAACACTGTCTTTGGATATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTTGATTTTAGTCTTCCTTTTTACATAACCCATTTT...
pathogenic
48,210
Is the genetic variant on chromosome 2, position 178560612, gene TTN, benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CTTCAGCCAGGTCAGGGAAACACTGTCTTTGGATATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTTGATTTTAGTCTTCCTTTTTACATAACCCATTTTGCTTCTGAACCAACCAAGGCTCCCACAAGCTATGTCATTACATGCTATAGCATTCAAATCCAAATTAAGGGTAAAATGACCAGATTAAATGATAAAATTT...
CTTCAGCCAGGTCAGGGAAACACTGTCTTTGGATATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTTGATTTTAGTCTTCCTTTTTACATAACCCATTTTGCTTCTGAACCAACCAAGGCTCCCACAAGCTATGTCATTACATGCTATAGCATTCAAATCCAAATTAAGGGTAAAATGACCAGATTAAATGATAAAATTT...
pathogenic
48,213
Chromosome 2, position 178560645, gene TTN: benign or pathogenic variant? If pathogenic, what are the linked illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTTGATTTTAGTCTTCCTTTTTACATAACCCATTTTGCTTCTGAACCAACCAAGGCTCCCACAAGCTATGTCATTACATGCTATAGCATTCAAATCCAAATTAAGGGTAAAATGACCAGATTAAATGATAAAATTTACTCCAAATTCACCATGGGGATAAAAAAGAGGA...
TATACTTGTTACTCCAAGTTTTTCAGGTGGGCTTGGTTTTTCTAAGAAAACAAAGCATCAAAAGAAAGTGAATAATTATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTTGATTTTAGTCTTCCTTTTTACATAACCCATTTTGCTTCTGAACCAACCAAGGCTCCCACAAGCTATGTCATTACATGCTATAGCATTCAAATCCAAATTAAGGGTAAAATGACCAGATTAAATGATAAAATTTACTCCAAATTCACCATGGGGATAAAAAAGAGGA...
pathogenic
48,218
Mutation found at chromosome 2 position 178560722, gene TTN: benign or pathogenic? If pathogenic, indicate the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTTGATTTTAGTCTTCCTTTTTACATAACCCATTTTGCTTCTGAACCAACCAAGGCTCCCACAAGCTATGTCATTACATGCTATAGCATTCAAATCCAAATTAAGGGTAAAATGACCAGATTAAATGATAAAATTTACTCCAAATTCACCATGGGGATAAAAAAGAGGAACAAGATGAACAATCTTTTAAAAAACTTTATATACAATTTCTGTACACACGCACATACACACATATGATATATGTCA...
ATTACAGCACTTTTAAATGTGCACTCTTCATGTATTGTCAAAAGAAAACTTTTAAATGAAGGCCATATTTTTATGTTGATTTTAGTCTTCCTTTTTACATAACCCATTTTGCTTCTGAACCAACCAAGGCTCCCACAAGCTATGTCATTACATGCTATAGCATTCAAATCCAAATTAAGGGTAAAATGACCAGATTAAATGATAAAATTTACTCCAAATTCACCATGGGGATAAAAAAGAGGAACAAGATGAACAATCTTTTAAAAAACTTTATATACAATTTCTGTACACACGCACATACACACATATGATATATGTCA...
pathogenic
48,222
The mutation in gene TTN at chromosome 2, position 178560928—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Primary_dilated_cardiomyopathy']
ATTTACTCCAAATTCACCATGGGGATAAAAAAGAGGAACAAGATGAACAATCTTTTAAAAAACTTTATATACAATTTCTGTACACACGCACATACACACATATGATATATGTCATACACACATACTATATATATATAATCTGTGTATATATATATATAAACATGTATACCTACATATATATACAGTTAGATTCAATAATACTTAAATTCAACATATATTATCCAATTTTAGCTACGTAAATTTCTGTTTTTTTAATCAATGAAAGACTCTTCACTAGAGATTCCATTTTGTGCCATAGTATGAATAGTTTGGGGTGTGAA...
ATTTACTCCAAATTCACCATGGGGATAAAAAAGAGGAACAAGATGAACAATCTTTTAAAAAACTTTATATACAATTTCTGTACACACGCACATACACACATATGATATATGTCATACACACATACTATATATATATAATCTGTGTATATATATATATAAACATGTATACCTACATATATATACAGTTAGATTCAATAATACTTAAATTCAACATATATTATCCAATTTTAGCTACGTAAATTTCTGTTTTTTTAATCAATGAAAGACTCTTCACTAGAGATTCCATTTTGTGCCATAGTATGAATAGTTTGGGGTGTGAA...
pathogenic
48,230
The chromosome 2, position 178561120 genetic variant in gene TTN: benign or pathogenic? If pathogenic, indicate disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CAATAATACTTAAATTCAACATATATTATCCAATTTTAGCTACGTAAATTTCTGTTTTTTTAATCAATGAAAGACTCTTCACTAGAGATTCCATTTTGTGCCATAGTATGAATAGTTTGGGGTGTGAAGGGTGTGAACCCAAAAGCATTTAAGATGAAATAACGACTAATTAGAATGACTCACACTATTCTAGCAAAATTAACGTGGATATGTAGAATTTCCTTATTCTTAAAACATACCTGTTATTTTTACTCCTTCCTTTGTTTCAGCTGGTATACCAACACCAAACTCATTTTCTCCAGAGACTCTGAAGTAATAGA...
CAATAATACTTAAATTCAACATATATTATCCAATTTTAGCTACGTAAATTTCTGTTTTTTTAATCAATGAAAGACTCTTCACTAGAGATTCCATTTTGTGCCATAGTATGAATAGTTTGGGGTGTGAAGGGTGTGAACCCAAAAGCATTTAAGATGAAATAACGACTAATTAGAATGACTCACACTATTCTAGCAAAATTAACGTGGATATGTAGAATTTCCTTATTCTTAAAACATACCTGTTATTTTTACTCCTTCCTTTGTTTCAGCTGGTATACCAACACCAAACTCATTTTCTCCAGAGACTCTGAAGTAATAGA...
pathogenic
48,241
The mutation impacting TTN on chromosome 2 at position 178561312: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GCAAAATTAACGTGGATATGTAGAATTTCCTTATTCTTAAAACATACCTGTTATTTTTACTCCTTCCTTTGTTTCAGCTGGTATACCAACACCAAACTCATTTTCTCCAGAGACTCTGAAGTAATAGATAGCTCCTTCTTGTAAATTGGTAACTTTGTAGGAGAGGCGGTTACAGTTGTTGGTCACAGAGACCCATGCTTTCTTGCTGGCCTCACGTTTTTCTATGTGGTAATTCTTCACTGGTGCTCCACCATCGTTTTCAGGAACATCCCAGGATAACACTGCAGACTCTTTGGTTACATCTTGCACAGTAATGTTGG...
GCAAAATTAACGTGGATATGTAGAATTTCCTTATTCTTAAAACATACCTGTTATTTTTACTCCTTCCTTTGTTTCAGCTGGTATACCAACACCAAACTCATTTTCTCCAGAGACTCTGAAGTAATAGATAGCTCCTTCTTGTAAATTGGTAACTTTGTAGGAGAGGCGGTTACAGTTGTTGGTCACAGAGACCCATGCTTTCTTGCTGGCCTCACGTTTTTCTATGTGGTAATTCTTCACTGGTGCTCCACCATCGTTTTCAGGAACATCCCAGGATAACACTGCAGACTCTTTGGTTACATCTTGCACAGTAATGTTGG...
pathogenic
48,248
Evaluate this variant at chromosome 2, position 178561542, gene TTN: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AATTCTTCACTGGTGCTCCACCATCGTTTTCAGGAACATCCCAGGATAACACTGCAGACTCTTTGGTTACATCTTGCACAGTAATGTTGGTTGGAGGACCTGGGGTATCTAAAACTTTGACAACTAAGGTCAGTGAAGCAGCACTCAAAACATTCTGAATTGTTAATGTGTACTTTCCAGAGTCATTTCTGTTGGCATTTTCAATGGTCAGTGATGTACGAGAGTCTGTGGTATCAACATAAGCTCTAGTACGGAGGTCAGTGTCTGGCTTACTCCACAAGACATTGGGTACTGGTCTTCCTCGGAAAGGCACAGTCATG...
AATTCTTCACTGGTGCTCCACCATCGTTTTCAGGAACATCCCAGGATAACACTGCAGACTCTTTGGTTACATCTTGCACAGTAATGTTGGTTGGAGGACCTGGGGTATCTAAAACTTTGACAACTAAGGTCAGTGAAGCAGCACTCAAAACATTCTGAATTGTTAATGTGTACTTTCCAGAGTCATTTCTGTTGGCATTTTCAATGGTCAGTGATGTACGAGAGTCTGTGGTATCAACATAAGCTCTAGTACGGAGGTCAGTGTCTGGCTTACTCCACAAGACATTGGGTACTGGTCTTCCTCGGAAAGGCACAGTCATG...
pathogenic
48,258
Variant in TTN, chromosome 2, position 178561627—is this benign or pathogenic? If pathogenic, what disease(s) is linked?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GTTGGTTGGAGGACCTGGGGTATCTAAAACTTTGACAACTAAGGTCAGTGAAGCAGCACTCAAAACATTCTGAATTGTTAATGTGTACTTTCCAGAGTCATTTCTGTTGGCATTTTCAATGGTCAGTGATGTACGAGAGTCTGTGGTATCAACATAAGCTCTAGTACGGAGGTCAGTGTCTGGCTTACTCCACAAGACATTGGGTACTGGTCTTCCTCGGAAAGGCACAGTCATGGTAAATGAGGCACCAGCCTTGACAATCAAGGTCTTCCTCATTTCACTGTCAATATCAAATAAAGGTTCTTCTTCTCTTTCCTTTG...
GTTGGTTGGAGGACCTGGGGTATCTAAAACTTTGACAACTAAGGTCAGTGAAGCAGCACTCAAAACATTCTGAATTGTTAATGTGTACTTTCCAGAGTCATTTCTGTTGGCATTTTCAATGGTCAGTGATGTACGAGAGTCTGTGGTATCAACATAAGCTCTAGTACGGAGGTCAGTGTCTGGCTTACTCCACAAGACATTGGGTACTGGTCTTCCTCGGAAAGGCACAGTCATGGTAAATGAGGCACCAGCCTTGACAATCAAGGTCTTCCTCATTTCACTGTCAATATCAAATAAAGGTTCTTCTTCTCTTTCCTTTG...
pathogenic
48,260
Evaluate this variant at chromosome 2, position 178561649, gene TTN: benign or pathogenic? If pathogenic, what are the disease connection(s)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TCTAAAACTTTGACAACTAAGGTCAGTGAAGCAGCACTCAAAACATTCTGAATTGTTAATGTGTACTTTCCAGAGTCATTTCTGTTGGCATTTTCAATGGTCAGTGATGTACGAGAGTCTGTGGTATCAACATAAGCTCTAGTACGGAGGTCAGTGTCTGGCTTACTCCACAAGACATTGGGTACTGGTCTTCCTCGGAAAGGCACAGTCATGGTAAATGAGGCACCAGCCTTGACAATCAAGGTCTTCCTCATTTCACTGTCAATATCAAATAAAGGTTCTTCTTCTCTTTCCTTTGCTATCTGAGGGTCAGAGCTATC...
TCTAAAACTTTGACAACTAAGGTCAGTGAAGCAGCACTCAAAACATTCTGAATTGTTAATGTGTACTTTCCAGAGTCATTTCTGTTGGCATTTTCAATGGTCAGTGATGTACGAGAGTCTGTGGTATCAACATAAGCTCTAGTACGGAGGTCAGTGTCTGGCTTACTCCACAAGACATTGGGTACTGGTCTTCCTCGGAAAGGCACAGTCATGGTAAATGAGGCACCAGCCTTGACAATCAAGGTCTTCCTCATTTCACTGTCAATATCAAATAAAGGTTCTTCTTCTCTTTCCTTTGCTATCTGAGGGTCAGAGCTATC...
pathogenic
48,262
Benign or pathogenic: chromosome 2, position 178561766, gene TTN variant? Disease(s) if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TCTGTGGTATCAACATAAGCTCTAGTACGGAGGTCAGTGTCTGGCTTACTCCACAAGACATTGGGTACTGGTCTTCCTCGGAAAGGCACAGTCATGGTAAATGAGGCACCAGCCTTGACAATCAAGGTCTTCCTCATTTCACTGTCAATATCAAATAAAGGTTCTTCTTCTCTTTCCTTTGCTATCTGAGGGTCAGAGCTATCACTGGGGTCACTAGCACCAACCTTATTGACAGATTTTACTCTGAAAACATATTCAGCTCCTGTTGTTAGTCCGCTTATTGTATATTCTGTCCCTCGTAAGCTCTGAATGGAAGTTTT...
TCTGTGGTATCAACATAAGCTCTAGTACGGAGGTCAGTGTCTGGCTTACTCCACAAGACATTGGGTACTGGTCTTCCTCGGAAAGGCACAGTCATGGTAAATGAGGCACCAGCCTTGACAATCAAGGTCTTCCTCATTTCACTGTCAATATCAAATAAAGGTTCTTCTTCTCTTTCCTTTGCTATCTGAGGGTCAGAGCTATCACTGGGGTCACTAGCACCAACCTTATTGACAGATTTTACTCTGAAAACATATTCAGCTCCTGTTGTTAGTCCGCTTATTGTATATTCTGTCCCTCGTAAGCTCTGAATGGAAGTTTT...
pathogenic
48,271
Chromosome 2, position 178561834, gene TTN: Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGGTCTTCCTCGGAAAGGCACAGTCATGGTAAATGAGGCACCAGCCTTGACAATCAAGGTCTTCCTCATTTCACTGTCAATATCAAATAAAGGTTCTTCTTCTCTTTCCTTTGCTATCTGAGGGTCAGAGCTATCACTGGGGTCACTAGCACCAACCTTATTGACAGATTTTACTCTGAAAACATATTCAGCTCCTGTTGTTAGTCCGCTTATTGTATATTCTGTCCCTCGTAAGCTCTGAATGGAAGTTTTCCAGTCAGTGTCATCAGATTTTTTGTATTCTACAGTATATCCAGTTATCGGGGCCCCACCATCAAACA...
TGGTCTTCCTCGGAAAGGCACAGTCATGGTAAATGAGGCACCAGCCTTGACAATCAAGGTCTTCCTCATTTCACTGTCAATATCAAATAAAGGTTCTTCTTCTCTTTCCTTTGCTATCTGAGGGTCAGAGCTATCACTGGGGTCACTAGCACCAACCTTATTGACAGATTTTACTCTGAAAACATATTCAGCTCCTGTTGTTAGTCCGCTTATTGTATATTCTGTCCCTCGTAAGCTCTGAATGGAAGTTTTCCAGTCAGTGTCATCAGATTTTTTGTATTCTACAGTATATCCAGTTATCGGGGCCCCACCATCAAACA...
pathogenic
48,273
Is chromosome 2, position 178562021, gene TTN variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TCAGCTCCTGTTGTTAGTCCGCTTATTGTATATTCTGTCCCTCGTAAGCTCTGAATGGAAGTTTTCCAGTCAGTGTCATCAGATTTTTTGTATTCTACAGTATATCCAGTTATCGGGGCCCCACCATCAAACAGCGGCTTAACCCAGGCAATAGTTATAGTTGTCTTGCCTGAGTCCACAATTTTGGGTTTGGATGGAGGAGATGGTAGGAACACTGGATCTTCTGCCCTAATTAAGGGAGAGGTTTCACTTGGAAGACTTAGGCCAGCAGCATTTTCTGCATAAACACGATATTCATATTCACATCCTTCCCGAAGTCC...
TCAGCTCCTGTTGTTAGTCCGCTTATTGTATATTCTGTCCCTCGTAAGCTCTGAATGGAAGTTTTCCAGTCAGTGTCATCAGATTTTTTGTATTCTACAGTATATCCAGTTATCGGGGCCCCACCATCAAACAGCGGCTTAACCCAGGCAATAGTTATAGTTGTCTTGCCTGAGTCCACAATTTTGGGTTTGGATGGAGGAGATGGTAGGAACACTGGATCTTCTGCCCTAATTAAGGGAGAGGTTTCACTTGGAAGACTTAGGCCAGCAGCATTTTCTGCATAAACACGATATTCATATTCACATCCTTCCCGAAGTCC...
pathogenic
48,281
Considering the variant on chromosome 2, location 178562065, involving gene TTN, would you classify it as benign or pathogenic? What disease(s), if any, does a pathogenic variant indicate?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TAAGCTCTGAATGGAAGTTTTCCAGTCAGTGTCATCAGATTTTTTGTATTCTACAGTATATCCAGTTATCGGGGCCCCACCATCAAACAGCGGCTTAACCCAGGCAATAGTTATAGTTGTCTTGCCTGAGTCCACAATTTTGGGTTTGGATGGAGGAGATGGTAGGAACACTGGATCTTCTGCCCTAATTAAGGGAGAGGTTTCACTTGGAAGACTTAGGCCAGCAGCATTTTCTGCATAAACACGATATTCATATTCACATCCTTCCCGAAGTCCTGTTGATTTCACTCTTAGATCATAAACTGGTTTTTTGTTTACAC...
TAAGCTCTGAATGGAAGTTTTCCAGTCAGTGTCATCAGATTTTTTGTATTCTACAGTATATCCAGTTATCGGGGCCCCACCATCAAACAGCGGCTTAACCCAGGCAATAGTTATAGTTGTCTTGCCTGAGTCCACAATTTTGGGTTTGGATGGAGGAGATGGTAGGAACACTGGATCTTCTGCCCTAATTAAGGGAGAGGTTTCACTTGGAAGACTTAGGCCAGCAGCATTTTCTGCATAAACACGATATTCATATTCACATCCTTCCCGAAGTCCTGTTGATTTCACTCTTAGATCATAAACTGGTTTTTTGTTTACAC...
pathogenic
48,283
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 2, position 178562296, gene TTN. What disease(s) is it linked to if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTCTGCATAAACACGATATTCATATTCACATCCTTCCCGAAGTCCTGTTGATTTCACTCTTAGATCATAAACTGGTTTTTTGTTTACACGCACCCATCTTAGGCTATTTTTCTCTCGCCTTTCAATTATATATCCAGATATTTCACTACCTCCATCACTCTCGGGTCTTGACCAGCAAAGTGTCATAGATTCTTTGGTCACAGAAGTAATTTCCAAAGACGTGGGTGGACTTGGAACTGTAAATGGATCTAGTGCCTTTATAGCTACACTCTCTAGGGGCTCACCAACACCATATTTATTAACACCAGTTACTCTAAATA...
TTCTGCATAAACACGATATTCATATTCACATCCTTCCCGAAGTCCTGTTGATTTCACTCTTAGATCATAAACTGGTTTTTTGTTTACACGCACCCATCTTAGGCTATTTTTCTCTCGCCTTTCAATTATATATCCAGATATTTCACTACCTCCATCACTCTCGGGTCTTGACCAGCAAAGTGTCATAGATTCTTTGGTCACAGAAGTAATTTCCAAAGACGTGGGTGGACTTGGAACTGTAAATGGATCTAGTGCCTTTATAGCTACACTCTCTAGGGGCTCACCAACACCATATTTATTAACACCAGTTACTCTAAATA...
pathogenic
48,290
Regarding the variant at chromosome 2 and position 178562380, affecting gene TTN: benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TACACGCACCCATCTTAGGCTATTTTTCTCTCGCCTTTCAATTATATATCCAGATATTTCACTACCTCCATCACTCTCGGGTCTTGACCAGCAAAGTGTCATAGATTCTTTGGTCACAGAAGTAATTTCCAAAGACGTGGGTGGACTTGGAACTGTAAATGGATCTAGTGCCTTTATAGCTACACTCTCTAGGGGCTCACCAACACCATATTTATTAACACCAGTTACTCTAAATATATATTCATTGCCTTTGAGTAACTTGGTTACTTTACAGGATGTCATCTGTAACTCTCCTTCACATATTGTCCATGCAAGGTGGC...
TACACGCACCCATCTTAGGCTATTTTTCTCTCGCCTTTCAATTATATATCCAGATATTTCACTACCTCCATCACTCTCGGGTCTTGACCAGCAAAGTGTCATAGATTCTTTGGTCACAGAAGTAATTTCCAAAGACGTGGGTGGACTTGGAACTGTAAATGGATCTAGTGCCTTTATAGCTACACTCTCTAGGGGCTCACCAACACCATATTTATTAACACCAGTTACTCTAAATATATATTCATTGCCTTTGAGTAACTTGGTTACTTTACAGGATGTCATCTGTAACTCTCCTTCACATATTGTCCATGCAAGGTGGC...
pathogenic
48,295
Is the genetic variant on chromosome 2, position 178562528, gene TTN, benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
GGAACTGTAAATGGATCTAGTGCCTTTATAGCTACACTCTCTAGGGGCTCACCAACACCATATTTATTAACACCAGTTACTCTAAATATATATTCATTGCCTTTGAGTAACTTGGTTACTTTACAGGATGTCATCTGTAACTCTCCTTCACATATTGTCCATGCAAGGTGGCTTGTTTCACGTTTTTCTACGATGTAATAGTCGATATCTGCACCACCATCTTCTTGGGGACGTCCCCAGGAAAGAGAGCATTTCTCAGCAGTGAGGCCATTTATTTCAAGTGGTCCTGCTGGTGGACCAGGCTTATCAAGTACTTTGCA...
GGAACTGTAAATGGATCTAGTGCCTTTATAGCTACACTCTCTAGGGGCTCACCAACACCATATTTATTAACACCAGTTACTCTAAATATATATTCATTGCCTTTGAGTAACTTGGTTACTTTACAGGATGTCATCTGTAACTCTCCTTCACATATTGTCCATGCAAGGTGGCTTGTTTCACGTTTTTCTACGATGTAATAGTCGATATCTGCACCACCATCTTCTTGGGGACGTCCCCAGGAAAGAGAGCATTTCTCAGCAGTGAGGCCATTTATTTCAAGTGGTCCTGCTGGTGGACCAGGCTTATCAAGTACTTTGCA...
pathogenic
48,302
Clinically, how would you classify the variant at chromosome 2, position 178562747, gene TTN: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TCTTCTTGGGGACGTCCCCAGGAAAGAGAGCATTTCTCAGCAGTGAGGCCATTTATTTCAAGTGGTCCTGCTGGTGGACCAGGCTTATCAAGTACTTTGCAATTAACGGCCACAGACCGAGTGCCGGCAACATTCTTCAGTGTTAGTACATATTGCCCAGTGTCTCGTCTTATACAGTCTTTAACTGTTAACAAAGTATGATTGTCTGTTGAGATGATTTCTGTTCTTGCTCTTTCTTCAATTTCTATACCATCCTTGGCCCAGGAAATTACTGGCAGAGGTCGCCCTGCAATGTCTGCATTTATCTTAAGGACCTCTCC...
TCTTCTTGGGGACGTCCCCAGGAAAGAGAGCATTTCTCAGCAGTGAGGCCATTTATTTCAAGTGGTCCTGCTGGTGGACCAGGCTTATCAAGTACTTTGCAATTAACGGCCACAGACCGAGTGCCGGCAACATTCTTCAGTGTTAGTACATATTGCCCAGTGTCTCGTCTTATACAGTCTTTAACTGTTAACAAAGTATGATTGTCTGTTGAGATGATTTCTGTTCTTGCTCTTTCTTCAATTTCTATACCATCCTTGGCCCAGGAAATTACTGGCAGAGGTCGCCCTGCAATGTCTGCATTTATCTTAAGGACCTCTCC...
pathogenic
48,315
The mutation in gene TTN at chromosome 2, position 178562807—clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy']
AGTGGTCCTGCTGGTGGACCAGGCTTATCAAGTACTTTGCAATTAACGGCCACAGACCGAGTGCCGGCAACATTCTTCAGTGTTAGTACATATTGCCCAGTGTCTCGTCTTATACAGTCTTTAACTGTTAACAAAGTATGATTGTCTGTTGAGATGATTTCTGTTCTTGCTCTTTCTTCAATTTCTATACCATCCTTGGCCCAGGAAATTACTGGCAGAGGTCGCCCTGCAATGTCTGCATTTATCTTAAGGACCTCTCCAGCTTTGACAACAATAACGTCTCGGAACTTGACATCCATCATAACTCTTGGAGGCTCAAC...
AGTGGTCCTGCTGGTGGACCAGGCTTATCAAGTACTTTGCAATTAACGGCCACAGACCGAGTGCCGGCAACATTCTTCAGTGTTAGTACATATTGCCCAGTGTCTCGTCTTATACAGTCTTTAACTGTTAACAAAGTATGATTGTCTGTTGAGATGATTTCTGTTCTTGCTCTTTCTTCAATTTCTATACCATCCTTGGCCCAGGAAATTACTGGCAGAGGTCGCCCTGCAATGTCTGCATTTATCTTAAGGACCTCTCCAGCTTTGACAACAATAACGTCTCGGAACTTGACATCCATCATAACTCTTGGAGGCTCAAC...
pathogenic
48,317
Determine if the mutation at chromosome 2, position 178563058 in gene TTN is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Early-onset_myopathy_with_fatal_cardiomyopathy', 'Hypertrophic_cardiomyopathy_9', 'Myopathy,_myofibrillar,_9,_with_early_respiratory_failure', 'Tibial_muscular_dystrophy']
GACCTCTCCAGCTTTGACAACAATAACGTCTCGGAACTTGACATCCATCATAACTCTTGGAGGCTCAACATCATCTTTAACTATAATAGGCCCAGTGGATTCAGATGGCTCACTAACTGAGTCAGCAGCATTCCTTGCAAAAACCCGGAATTCATAACGCTGATCTTCAGTAAGTTCAGTTACTTCAAAGTATGTTTCTTGTATATTAGTATAATTGCACTTCAGCCACCGGCCATCTGGTAGTTCTCTGCGTTCAACAATGTATCCTGTGATCTTAGCTCCACCATCATAATGTGGTTTAGACCATTTAAGTGACACTG...
GACCTCTCCAGCTTTGACAACAATAACGTCTCGGAACTTGACATCCATCATAACTCTTGGAGGCTCAACATCATCTTTAACTATAATAGGCCCAGTGGATTCAGATGGCTCACTAACTGAGTCAGCAGCATTCCTTGCAAAAACCCGGAATTCATAACGCTGATCTTCAGTAAGTTCAGTTACTTCAAAGTATGTTTCTTGTATATTAGTATAATTGCACTTCAGCCACCGGCCATCTGGTAGTTCTCTGCGTTCAACAATGTATCCTGTGATCTTAGCTCCACCATCATAATGTGGTTTAGACCATTTAAGTGACACTG...
pathogenic
48,332
A genetic variant on chromosome 2, position 178563219, affects the gene TTN. Is this variant benign or pathogenic? If pathogenic, what disease(s) does it cause?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Dilated_cardiomyopathy_1G']
GATCTTCAGTAAGTTCAGTTACTTCAAAGTATGTTTCTTGTATATTAGTATAATTGCACTTCAGCCACCGGCCATCTGGTAGTTCTCTGCGTTCAACAATGTATCCTGTGATCTTAGCTCCACCATCATAATGTGGTTTAGACCATTTAAGTGACACTGATTTTCTTGTGATATTTGTGACTTCAGGTTGTCCAGGAGGGTCACAAGGATCTCTTGCAGGGACTGGTTCACAAGATTTACTGCATTTACCAATTCCAGCAATATTTTCAGCATATACACGATACTCATACATCAGTCCTTCATCAAGGCCGGAGACTTTC...
GATCTTCAGTAAGTTCAGTTACTTCAAAGTATGTTTCTTGTATATTAGTATAATTGCACTTCAGCCACCGGCCATCTGGTAGTTCTCTGCGTTCAACAATGTATCCTGTGATCTTAGCTCCACCATCATAATGTGGTTTAGACCATTTAAGTGACACTGATTTTCTTGTGATATTTGTGACTTCAGGTTGTCCAGGAGGGTCACAAGGATCTCTTGCAGGGACTGGTTCACAAGATTTACTGCATTTACCAATTCCAGCAATATTTTCAGCATATACACGATACTCATACATCAGTCCTTCATCAAGGCCGGAGACTTTC...
pathogenic
48,341
Considering the genetic mutation at chromosome 2, position 178563235, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AGTTACTTCAAAGTATGTTTCTTGTATATTAGTATAATTGCACTTCAGCCACCGGCCATCTGGTAGTTCTCTGCGTTCAACAATGTATCCTGTGATCTTAGCTCCACCATCATAATGTGGTTTAGACCATTTAAGTGACACTGATTTTCTTGTGATATTTGTGACTTCAGGTTGTCCAGGAGGGTCACAAGGATCTCTTGCAGGGACTGGTTCACAAGATTTACTGCATTTACCAATTCCAGCAATATTTTCAGCATATACACGATACTCATACATCAGTCCTTCATCAAGGCCGGAGACTTTCATTTGAGTATCAGCAA...
AGTTACTTCAAAGTATGTTTCTTGTATATTAGTATAATTGCACTTCAGCCACCGGCCATCTGGTAGTTCTCTGCGTTCAACAATGTATCCTGTGATCTTAGCTCCACCATCATAATGTGGTTTAGACCATTTAAGTGACACTGATTTTCTTGTGATATTTGTGACTTCAGGTTGTCCAGGAGGGTCACAAGGATCTCTTGCAGGGACTGGTTCACAAGATTTACTGCATTTACCAATTCCAGCAATATTTTCAGCATATACACGATACTCATACATCAGTCCTTCATCAAGGCCGGAGACTTTCATTTGAGTATCAGCAA...
pathogenic
48,344
Does the genetic variant at chromosome 2, position 178563533, impacting gene TTN, appear benign or pathogenic? If pathogenic, name the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ACTTTCATTTGAGTATCAGCAATGAGGATTTTATTTGCTTTTGACCAAAGAATGCTGCTTCTTTCTTTATACTCAAGATGATAGCCAATTACTCGACTTCCTCCATCATTAACTGGCACTTGCCAGGTTACAAGCATGGTAGATTTTGTGGCATGCACAACTTTAGGAGTACCAGGAGGACCTGGGGGACTGAATGGATACTCTGCAACAACAGCTGAAGATTCACTGTAGGAGCTCTTTCCATAGCGGTTTTCTGCACAAACACGGAACTGATACTCACTTCCTGTTGTCAGGCGAACTATTTTAATGGATGTTCTTGC...
ACTTTCATTTGAGTATCAGCAATGAGGATTTTATTTGCTTTTGACCAAAGAATGCTGCTTCTTTCTTTATACTCAAGATGATAGCCAATTACTCGACTTCCTCCATCATTAACTGGCACTTGCCAGGTTACAAGCATGGTAGATTTTGTGGCATGCACAACTTTAGGAGTACCAGGAGGACCTGGGGGACTGAATGGATACTCTGCAACAACAGCTGAAGATTCACTGTAGGAGCTCTTTCCATAGCGGTTTTCTGCACAAACACGGAACTGATACTCACTTCCTGTTGTCAGGCGAACTATTTTAATGGATGTTCTTGC...
pathogenic
48,362
Is the variant located on chromosome 2 at position 178563537, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TCATTTGAGTATCAGCAATGAGGATTTTATTTGCTTTTGACCAAAGAATGCTGCTTCTTTCTTTATACTCAAGATGATAGCCAATTACTCGACTTCCTCCATCATTAACTGGCACTTGCCAGGTTACAAGCATGGTAGATTTTGTGGCATGCACAACTTTAGGAGTACCAGGAGGACCTGGGGGACTGAATGGATACTCTGCAACAACAGCTGAAGATTCACTGTAGGAGCTCTTTCCATAGCGGTTTTCTGCACAAACACGGAACTGATACTCACTTCCTGTTGTCAGGCGAACTATTTTAATGGATGTTCTTGCAACT...
TCATTTGAGTATCAGCAATGAGGATTTTATTTGCTTTTGACCAAAGAATGCTGCTTCTTTCTTTATACTCAAGATGATAGCCAATTACTCGACTTCCTCCATCATTAACTGGCACTTGCCAGGTTACAAGCATGGTAGATTTTGTGGCATGCACAACTTTAGGAGTACCAGGAGGACCTGGGGGACTGAATGGATACTCTGCAACAACAGCTGAAGATTCACTGTAGGAGCTCTTTCCATAGCGGTTTTCTGCACAAACACGGAACTGATACTCACTTCCTGTTGTCAGGCGAACTATTTTAATGGATGTTCTTGCAACT...
pathogenic
48,363
Clinical significance of chromosome 2, position 178563938, gene TTN: benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TATTCTGGAGGATTCCAAGAAATGGTTATGCTGTCACAACTAACCTCATCAATACGTATAGGACCTGGAGGTCCTGGTCTGTCAAGGACAATTATAGTAATAGGAACTGTTATGGATCCAGCACTGTTTGAAACACATAATTCATAAGTTCCAACATCTTCCTTTGAAGCTTCCTTAATAGATAGTGATGTTACAGTCTTTGAAGAAGAAACATTGACTCTAGTTGTCTCTTTAAGAGTCTGACCATCTTTTCTCCAGTTCACAGTAGCTTGAGGTCTTCCTTTGAATGGCACATCAATCTTAAGTTGTTCTCTAGCCTT...
TATTCTGGAGGATTCCAAGAAATGGTTATGCTGTCACAACTAACCTCATCAATACGTATAGGACCTGGAGGTCCTGGTCTGTCAAGGACAATTATAGTAATAGGAACTGTTATGGATCCAGCACTGTTTGAAACACATAATTCATAAGTTCCAACATCTTCCTTTGAAGCTTCCTTAATAGATAGTGATGTTACAGTCTTTGAAGAAGAAACATTGACTCTAGTTGTCTCTTTAAGAGTCTGACCATCTTTTCTCCAGTTCACAGTAGCTTGAGGTCTTCCTTTGAATGGCACATCAATCTTAAGTTGTTCTCTAGCCTT...
pathogenic
48,380
Considering the genetic mutation at chromosome 2, position 178563945, impacting TTN: is it clinically benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GAGGATTCCAAGAAATGGTTATGCTGTCACAACTAACCTCATCAATACGTATAGGACCTGGAGGTCCTGGTCTGTCAAGGACAATTATAGTAATAGGAACTGTTATGGATCCAGCACTGTTTGAAACACATAATTCATAAGTTCCAACATCTTCCTTTGAAGCTTCCTTAATAGATAGTGATGTTACAGTCTTTGAAGAAGAAACATTGACTCTAGTTGTCTCTTTAAGAGTCTGACCATCTTTTCTCCAGTTCACAGTAGCTTGAGGTCTTCCTTTGAATGGCACATCAATCTTAAGTTGTTCTCTAGCCTTTACATTG...
GAGGATTCCAAGAAATGGTTATGCTGTCACAACTAACCTCATCAATACGTATAGGACCTGGAGGTCCTGGTCTGTCAAGGACAATTATAGTAATAGGAACTGTTATGGATCCAGCACTGTTTGAAACACATAATTCATAAGTTCCAACATCTTCCTTTGAAGCTTCCTTAATAGATAGTGATGTTACAGTCTTTGAAGAAGAAACATTGACTCTAGTTGTCTCTTTAAGAGTCTGACCATCTTTTCTCCAGTTCACAGTAGCTTGAGGTCTTCCTTTGAATGGCACATCAATCTTAAGTTGTTCTCTAGCCTTTACATTG...
pathogenic
48,381
Determine if the mutation at chromosome 2, position 178564245 in gene TTN is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
GTTCTCTAGCCTTTACATTGAAAGTATGGAAAGGAAGCTCAACTGAAGGCTTTATTTCAATATCCCTTGCAATTACTGGCACTCCAAGTTGTCTTGGATCACTTCTTCCCTTTTCGTTAACTGCAGCTACCCTGAAGACATACTCTTCTCCTGCAGTTAAGCCAGATATAGTTGCTTCTAGAGTCTTAACTTGTGTGCAGGTGCTCCACTTTTCACTCCCTTTAGTCTGCATTTCAACCACATAACCAGTAATTTTGCTGCCACCATCACTTTCTGGTTTCTCCCACTTAATTGTAGCTGTATTACGGGTCACATCAACA...
GTTCTCTAGCCTTTACATTGAAAGTATGGAAAGGAAGCTCAACTGAAGGCTTTATTTCAATATCCCTTGCAATTACTGGCACTCCAAGTTGTCTTGGATCACTTCTTCCCTTTTCGTTAACTGCAGCTACCCTGAAGACATACTCTTCTCCTGCAGTTAAGCCAGATATAGTTGCTTCTAGAGTCTTAACTTGTGTGCAGGTGCTCCACTTTTCACTCCCTTTAGTCTGCATTTCAACCACATAACCAGTAATTTTGCTGCCACCATCACTTTCTGGTTTCTCCCACTTAATTGTAGCTGTATTACGGGTCACATCAACA...
pathogenic
48,394
Is the chromosome 2, position 178564252 variant in TTN clinically benign or pathogenic? If pathogenic, what condition(s) is associated?
pathogenic; ['Primary_dilated_cardiomyopathy']
AGCCTTTACATTGAAAGTATGGAAAGGAAGCTCAACTGAAGGCTTTATTTCAATATCCCTTGCAATTACTGGCACTCCAAGTTGTCTTGGATCACTTCTTCCCTTTTCGTTAACTGCAGCTACCCTGAAGACATACTCTTCTCCTGCAGTTAAGCCAGATATAGTTGCTTCTAGAGTCTTAACTTGTGTGCAGGTGCTCCACTTTTCACTCCCTTTAGTCTGCATTTCAACCACATAACCAGTAATTTTGCTGCCACCATCACTTTCTGGTTTCTCCCACTTAATTGTAGCTGTATTACGGGTCACATCAACAAGAGTTA...
AGCCTTTACATTGAAAGTATGGAAAGGAAGCTCAACTGAAGGCTTTATTTCAATATCCCTTGCAATTACTGGCACTCCAAGTTGTCTTGGATCACTTCTTCCCTTTTCGTTAACTGCAGCTACCCTGAAGACATACTCTTCTCCTGCAGTTAAGCCAGATATAGTTGCTTCTAGAGTCTTAACTTGTGTGCAGGTGCTCCACTTTTCACTCCCTTTAGTCTGCATTTCAACCACATAACCAGTAATTTTGCTGCCACCATCACTTTCTGGTTTCTCCCACTTAATTGTAGCTGTATTACGGGTCACATCAACAAGAGTTA...
pathogenic
48,395
Determine whether the variant at chromosome 2, position 178564373, in gene TTN is benign or pathogenic. If pathogenic, identify the relevant disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
ACCCTGAAGACATACTCTTCTCCTGCAGTTAAGCCAGATATAGTTGCTTCTAGAGTCTTAACTTGTGTGCAGGTGCTCCACTTTTCACTCCCTTTAGTCTGCATTTCAACCACATAACCAGTAATTTTGCTGCCACCATCACTTTCTGGTTTCTCCCACTTAATTGTAGCTGTATTACGGGTCACATCAACAAGAGTTACTCTTCCAGGTGGGAGGGGTGGTTCAGACACTTTAACGGGTTCTGTTGTTTCAGCTGGCAAACCAATCCCATATTCATTGGAAGCCAAGACTCGGAAGTAGTAAGAACATCCTTCTTGTAG...
ACCCTGAAGACATACTCTTCTCCTGCAGTTAAGCCAGATATAGTTGCTTCTAGAGTCTTAACTTGTGTGCAGGTGCTCCACTTTTCACTCCCTTTAGTCTGCATTTCAACCACATAACCAGTAATTTTGCTGCCACCATCACTTTCTGGTTTCTCCCACTTAATTGTAGCTGTATTACGGGTCACATCAACAAGAGTTACTCTTCCAGGTGGGAGGGGTGGTTCAGACACTTTAACGGGTTCTGTTGTTTCAGCTGGCAAACCAATCCCATATTCATTGGAAGCCAAGACTCGGAAGTAGTAAGAACATCCTTCTTGTAG...
pathogenic
48,404
Chromosome 2, position 178564787, gene TTN: Is this mutation clinically benign or pathogenic? If pathogenic, identify the related disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiomyopathy', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
ATCTTAGCTCCACCATCAATAAGTGGTGGTTCCCAGGACAACGTCACTGAGTCTTTCTTCACTTCTCTTATGGTCAAATTCACAGGGGCACTTGGTGAGTCAAGAACTCTGACGTTAACAAAAGCTGTTTTGGAGCCACTATTATTTTCTAATGTCAGATTATACCGACCACTGTCAAATCTGGTAACATTATCAATCACCAACATTGTAAATGAGCTGGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGT...
ATCTTAGCTCCACCATCAATAAGTGGTGGTTCCCAGGACAACGTCACTGAGTCTTTCTTCACTTCTCTTATGGTCAAATTCACAGGGGCACTTGGTGAGTCAAGAACTCTGACGTTAACAAAAGCTGTTTTGGAGCCACTATTATTTTCTAATGTCAGATTATACCGACCACTGTCAAATCTGGTAACATTATCAATCACCAACATTGTAAATGAGCTGGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGT...
pathogenic
48,422
Variant in gene TTN, located at chromosome 2 position 178564862: benign or pathogenic? What disease(s) does it cause if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
AAATTCACAGGGGCACTTGGTGAGTCAAGAACTCTGACGTTAACAAAAGCTGTTTTGGAGCCACTATTATTTTCTAATGTCAGATTATACCGACCACTGTCAAATCTGGTAACATTATCAATCACCAACATTGTAAATGAGCTGGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGTAGCACTTGCACGCAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTG...
AAATTCACAGGGGCACTTGGTGAGTCAAGAACTCTGACGTTAACAAAAGCTGTTTTGGAGCCACTATTATTTTCTAATGTCAGATTATACCGACCACTGTCAAATCTGGTAACATTATCAATCACCAACATTGTAAATGAGCTGGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGTAGCACTTGCACGCAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTG...
pathogenic
48,427
Does the variant on chromosome 2 at location 178564870 affecting gene TTN have a clinical significance of benign or pathogenic? If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
AGGGGCACTTGGTGAGTCAAGAACTCTGACGTTAACAAAAGCTGTTTTGGAGCCACTATTATTTTCTAATGTCAGATTATACCGACCACTGTCAAATCTGGTAACATTATCAATCACCAACATTGTAAATGAGCTGGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGTAGCACTTGCACGCAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTGAGCAACCA...
AGGGGCACTTGGTGAGTCAAGAACTCTGACGTTAACAAAAGCTGTTTTGGAGCCACTATTATTTTCTAATGTCAGATTATACCGACCACTGTCAAATCTGGTAACATTATCAATCACCAACATTGTAAATGAGCTGGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGTAGCACTTGCACGCAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTGAGCAACCA...
pathogenic
48,428
Is the genetic mutation found on chromosome 2 at position 178564929, within the gene TTN, considered benign or pathogenic? If pathogenic, specify the associated disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TATTTTCTAATGTCAGATTATACCGACCACTGTCAAATCTGGTAACATTATCAATCACCAACATTGTAAATGAGCTGGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGTAGCACTTGCACGCAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTGAGCAACCACTGAGCCAGGTAGAGTTGCAGGTTCACCTACACCTTCAGAATTGATGGCACAAATACGG...
TATTTTCTAATGTCAGATTATACCGACCACTGTCAAATCTGGTAACATTATCAATCACCAACATTGTAAATGAGCTGGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGTAGCACTTGCACGCAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTGAGCAACCACTGAGCCAGGTAGAGTTGCAGGTTCACCTACACCTTCAGAATTGATGGCACAAATACGG...
pathogenic
48,430
Does the chromosome 2 mutation at position 178565005 within gene TTN classify as benign or pathogenic? If pathogenic, indicate the related illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGTAGCACTTGCACGCAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTGAGCAACCACTGAGCCAGGTAGAGTTGCAGGTTCACCTACACCTTCAGAATTGATGGCACAAATACGGAAGTTATATTCAGTGTTTTCTTTAAGCTTGGTCACTGTGAACTGCTTTCCTTGTAATCCTGTTGGTGGAGTGCAGG...
GGTCACCTCTATCTGAGCCCTGTCAGTGAGAATGCCTTCTGCCTTTTCCCATTTAACTTCGGGTTCTGGTCGACCTTTGATAGTGACAAATAAGCGTAAAGTAGCACTTGCACGCAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTGAGCAACCACTGAGCCAGGTAGAGTTGCAGGTTCACCTACACCTTCAGAATTGATGGCACAAATACGGAAGTTATATTCAGTGTTTTCTTTAAGCTTGGTCACTGTGAACTGCTTTCCTTGTAATCCTGTTGGTGGAGTGCAGG...
pathogenic
48,436
Clinically, how would you classify the variant at chromosome 2, position 178565119, gene TTN: benign or pathogenic? If pathogenic, specify the associated illness(es).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
CAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTGAGCAACCACTGAGCCAGGTAGAGTTGCAGGTTCACCTACACCTTCAGAATTGATGGCACAAATACGGAAGTTATATTCAGTGTTTTCTTTAAGCTTGGTCACTGTGAACTGCTTTCCTTGTAATCCTGTTGGTGGAGTGCAGGTTGTCCATTCATCCGCAGCAGCTTCTTTGACCTCTACAACATAGCCTTTAACAGGTGCGCCACCATCATAAATTGGCTTACTCCATGCCAGGGAGACAGAAGATCTGGAAGTGT...
CAGAACGACCACCTTTCTGAGATCAGCATCGAGTTCTATTTCTGGTGGCTCTATCCTCTCCTGAGCAACCACTGAGCCAGGTAGAGTTGCAGGTTCACCTACACCTTCAGAATTGATGGCACAAATACGGAAGTTATATTCAGTGTTTTCTTTAAGCTTGGTCACTGTGAACTGCTTTCCTTGTAATCCTGTTGGTGGAGTGCAGGTTGTCCATTCATCCGCAGCAGCTTCTTTGACCTCTACAACATAGCCTTTAACAGGTGCGCCACCATCATAAATTGGCTTACTCCATGCCAGGGAGACAGAAGATCTGGAAGTGT...
pathogenic
48,441
Is chromosome 2, position 178565235, gene TTN variant benign or pathogenic? If pathogenic, what condition(s) is it related to?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TGGCACAAATACGGAAGTTATATTCAGTGTTTTCTTTAAGCTTGGTCACTGTGAACTGCTTTCCTTGTAATCCTGTTGGTGGAGTGCAGGTTGTCCATTCATCCGCAGCAGCTTCTTTGACCTCTACAACATAGCCTTTAACAGGTGCGCCACCATCATAAATTGGCTTACTCCATGCCAGGGAGACAGAAGATCTGGAAGTGTCCGTCACTTTTGGATTGCTTGGGGGACCTGGTGGATACAAGGCATCACACGCACGGTAGAAAACAGATGGCTCACTAGGTTCTCCCACACCAGCTGCATTTTCAGCAGCAACTCTG...
TGGCACAAATACGGAAGTTATATTCAGTGTTTTCTTTAAGCTTGGTCACTGTGAACTGCTTTCCTTGTAATCCTGTTGGTGGAGTGCAGGTTGTCCATTCATCCGCAGCAGCTTCTTTGACCTCTACAACATAGCCTTTAACAGGTGCGCCACCATCATAAATTGGCTTACTCCATGCCAGGGAGACAGAAGATCTGGAAGTGTCCGTCACTTTTGGATTGCTTGGGGGACCTGGTGGATACAAGGCATCACACGCACGGTAGAAAACAGATGGCTCACTAGGTTCTCCCACACCAGCTGCATTTTCAGCAGCAACTCTG...
pathogenic
48,450
The mutation impacting TTN on chromosome 2 at position 178565278: benign or pathogenic? Name the associated disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
GGTCACTGTGAACTGCTTTCCTTGTAATCCTGTTGGTGGAGTGCAGGTTGTCCATTCATCCGCAGCAGCTTCTTTGACCTCTACAACATAGCCTTTAACAGGTGCGCCACCATCATAAATTGGCTTACTCCATGCCAGGGAGACAGAAGATCTGGAAGTGTCCGTCACTTTTGGATTGCTTGGGGGACCTGGTGGATACAAGGCATCACACGCACGGTAGAAAACAGATGGCTCACTAGGTTCTCCCACACCAGCTGCATTTTCAGCAGCAACTCTGAATTCATAGGAATGGCCTTCGGTAAGACCAGTTACCCTGAGCC...
GGTCACTGTGAACTGCTTTCCTTGTAATCCTGTTGGTGGAGTGCAGGTTGTCCATTCATCCGCAGCAGCTTCTTTGACCTCTACAACATAGCCTTTAACAGGTGCGCCACCATCATAAATTGGCTTACTCCATGCCAGGGAGACAGAAGATCTGGAAGTGTCCGTCACTTTTGGATTGCTTGGGGGACCTGGTGGATACAAGGCATCACACGCACGGTAGAAAACAGATGGCTCACTAGGTTCTCCCACACCAGCTGCATTTTCAGCAGCAACTCTGAATTCATAGGAATGGCCTTCGGTAAGACCAGTTACCCTGAGCC...
pathogenic
48,454
Evaluate the clinical significance of the mutation at chromosome 2, position 178565366 in gene TTN: benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
TAGCCTTTAACAGGTGCGCCACCATCATAAATTGGCTTACTCCATGCCAGGGAGACAGAAGATCTGGAAGTGTCCGTCACTTTTGGATTGCTTGGGGGACCTGGTGGATACAAGGCATCACACGCACGGTAGAAAACAGATGGCTCACTAGGTTCTCCCACACCAGCTGCATTTTCAGCAGCAACTCTGAATTCATAGGAATGGCCTTCGGTAAGACCAGTTACCCTGAGCCGCAGATCCGTTAATGTTTTCTTGTTGCACTTGGTCCATCTAACGCCTTCCTTATCTCGTTTTTCAAGAATGTAGCCCTCAATTTCGGT...
TAGCCTTTAACAGGTGCGCCACCATCATAAATTGGCTTACTCCATGCCAGGGAGACAGAAGATCTGGAAGTGTCCGTCACTTTTGGATTGCTTGGGGGACCTGGTGGATACAAGGCATCACACGCACGGTAGAAAACAGATGGCTCACTAGGTTCTCCCACACCAGCTGCATTTTCAGCAGCAACTCTGAATTCATAGGAATGGCCTTCGGTAAGACCAGTTACCCTGAGCCGCAGATCCGTTAATGTTTTCTTGTTGCACTTGGTCCATCTAACGCCTTCCTTATCTCGTTTTTCAAGAATGTAGCCCTCAATTTCGGT...
pathogenic
48,462
Determine if the mutation at chromosome 2, position 178565547 in gene TTN is benign or pathogenic. If pathogenic, what disease(s) is associated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CAACTCTGAATTCATAGGAATGGCCTTCGGTAAGACCAGTTACCCTGAGCCGCAGATCCGTTAATGTTTTCTTGTTGCACTTGGTCCATCTAACGCCTTCCTTATCTCGTTTTTCAAGAATGTAGCCCTCAATTTCGGTACCTCCGTCGTCTACTGGGCGTGCCCATGTTACTACCATAGAATCTTTGGTGATTGCTGAGACTTCAGGTGTTGAGGGAGGACCTGGTGGCTTATAAGGATTACAGGCCGTAACAGGCCCAGATTCCAAGGGCTCTCCAATTCCATATTTATTCACAGCCATGACACGGAAAATGTACTCA...
CAACTCTGAATTCATAGGAATGGCCTTCGGTAAGACCAGTTACCCTGAGCCGCAGATCCGTTAATGTTTTCTTGTTGCACTTGGTCCATCTAACGCCTTCCTTATCTCGTTTTTCAAGAATGTAGCCCTCAATTTCGGTACCTCCGTCGTCTACTGGGCGTGCCCATGTTACTACCATAGAATCTTTGGTGATTGCTGAGACTTCAGGTGTTGAGGGAGGACCTGGTGGCTTATAAGGATTACAGGCCGTAACAGGCCCAGATTCCAAGGGCTCTCCAATTCCATATTTATTCACAGCCATGACACGGAAAATGTACTCA...
pathogenic
48,471
Variant at chromosome 2, position 178565745, gene TTN: clinically benign or pathogenic? If pathogenic, specify the disease(s) involved.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AGACTTCAGGTGTTGAGGGAGGACCTGGTGGCTTATAAGGATTACAGGCCGTAACAGGCCCAGATTCCAAGGGCTCTCCAATTCCATATTTATTCACAGCCATGACACGGAAAATGTACTCATTACCAGGAAGAAGTTTAGTAACTTTGTAGTTAAGGGCCTGTACCTCAGTTGAAACCTGGGTCCAAGAGAGTCGGCTTGTCTCCCTCTTTTCAATGATGTAATGTGAAATATTAGCACCACCATCTTGCAAAGGTGGGTTCCATGCCAGGTAACATTTTTCCGCAGTAACTCCAGTAACTTTCAGAGGCCCTTCAGGA...
AGACTTCAGGTGTTGAGGGAGGACCTGGTGGCTTATAAGGATTACAGGCCGTAACAGGCCCAGATTCCAAGGGCTCTCCAATTCCATATTTATTCACAGCCATGACACGGAAAATGTACTCATTACCAGGAAGAAGTTTAGTAACTTTGTAGTTAAGGGCCTGTACCTCAGTTGAAACCTGGGTCCAAGAGAGTCGGCTTGTCTCCCTCTTTTCAATGATGTAATGTGAAATATTAGCACCACCATCTTGCAAAGGTGGGTTCCATGCCAGGTAACATTTTTCCGCAGTAACTCCAGTAACTTTCAGAGGCCCTTCAGGA...
pathogenic
48,479
Assess the clinical significance (benign or pathogenic) of the variant at chromosome 2, position 178565929, gene TTN. What disease(s) is it linked to if pathogenic?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CCAAGAGAGTCGGCTTGTCTCCCTCTTTTCAATGATGTAATGTGAAATATTAGCACCACCATCTTGCAAAGGTGGGTTCCATGCCAGGTAACATTTTTCCGCAGTAACTCCAGTAACTTTCAGAGGCCCTTCAGGAGGCCCTGGCCTGTCAAGTACCTTTACAGTGATGGGTATAGACTTTGTACCACCAACATTGCTGAGTTTCAGAATATATTGTCCTCCATCAGTCCGTATACAGTCTTTGACAACAAGAGTTGTTTTCTGAATAGTAGATTTAATTTCCATTCTAGCAGCTGTTTCTTCAAGTTCTTTTCCATCTT...
CCAAGAGAGTCGGCTTGTCTCCCTCTTTTCAATGATGTAATGTGAAATATTAGCACCACCATCTTGCAAAGGTGGGTTCCATGCCAGGTAACATTTTTCCGCAGTAACTCCAGTAACTTTCAGAGGCCCTTCAGGAGGCCCTGGCCTGTCAAGTACCTTTACAGTGATGGGTATAGACTTTGTACCACCAACATTGCTGAGTTTCAGAATATATTGTCCTCCATCAGTCCGTATACAGTCTTTGACAACAAGAGTTGTTTTCTGAATAGTAGATTTAATTTCCATTCTAGCAGCTGTTTCTTCAAGTTCTTTTCCATCTT...
pathogenic
48,484
Mutation at chromosome 2, position 178566005, within TTN: benign or pathogenic? If pathogenic, indicate the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
TTCCATGCCAGGTAACATTTTTCCGCAGTAACTCCAGTAACTTTCAGAGGCCCTTCAGGAGGCCCTGGCCTGTCAAGTACCTTTACAGTGATGGGTATAGACTTTGTACCACCAACATTGCTGAGTTTCAGAATATATTGTCCTCCATCAGTCCGTATACAGTCTTTGACAACAAGAGTTGTTTTCTGAATAGTAGATTTAATTTCCATTCTAGCAGCTGTTTCTTCAAGTTCTTTTCCATCTTTTGACCAAACAACATCAGGTATAGGTTTGCCACGGATGTCGGCTTCAAGAACAAAAGTCTCTCCTGCATGAACAAC...
TTCCATGCCAGGTAACATTTTTCCGCAGTAACTCCAGTAACTTTCAGAGGCCCTTCAGGAGGCCCTGGCCTGTCAAGTACCTTTACAGTGATGGGTATAGACTTTGTACCACCAACATTGCTGAGTTTCAGAATATATTGTCCTCCATCAGTCCGTATACAGTCTTTGACAACAAGAGTTGTTTTCTGAATAGTAGATTTAATTTCCATTCTAGCAGCTGTTTCTTCAAGTTCTTTTCCATCTTTTGACCAAACAACATCAGGTATAGGTTTGCCACGGATGTCGGCTTCAAGAACAAAAGTCTCTCCTGCATGAACAAC...
pathogenic
48,488
Gene mutation in TTN at chromosome 2, position 178566084—is it benign or pathogenic? If pathogenic, specify the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
CCTTTACAGTGATGGGTATAGACTTTGTACCACCAACATTGCTGAGTTTCAGAATATATTGTCCTCCATCAGTCCGTATACAGTCTTTGACAACAAGAGTTGTTTTCTGAATAGTAGATTTAATTTCCATTCTAGCAGCTGTTTCTTCAAGTTCTTTTCCATCTTTTGACCAAACAACATCAGGTATAGGTTTGCCACGGATGTCGGCTTCAAGAACAAAAGTCTCTCCTGCATGAACAACGATGACATCTTTATATTTTGGATCCAGAGAGGCATTTGGTGCATCAATTTCATCTCTTGCAGTAATGGCACCACTACTA...
CCTTTACAGTGATGGGTATAGACTTTGTACCACCAACATTGCTGAGTTTCAGAATATATTGTCCTCCATCAGTCCGTATACAGTCTTTGACAACAAGAGTTGTTTTCTGAATAGTAGATTTAATTTCCATTCTAGCAGCTGTTTCTTCAAGTTCTTTTCCATCTTTTGACCAAACAACATCAGGTATAGGTTTGCCACGGATGTCGGCTTCAAGAACAAAAGTCTCTCCTGCATGAACAACGATGACATCTTTATATTTTGGATCCAGAGAGGCATTTGGTGCATCAATTTCATCTCTTGCAGTAATGGCACCACTACTA...
pathogenic
48,494
Does the variant impacting TTN on chromosome 2, position 178566283, classify as benign or pathogenic? If pathogenic, what disease(s) is it associated with?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G', 'Primary_dilated_cardiomyopathy']
GATGTCGGCTTCAAGAACAAAAGTCTCTCCTGCATGAACAACGATGACATCTTTATATTTTGGATCCAGAGAGGCATTTGGTGCATCAATTTCATCTCTTGCAGTAATGGCACCACTACTATCAGATGGTTCACTAAAGTTTCCAGCTGCATTTCTTGCAATTACTCTAAATTCATATCTTTGGTCTTCTACAAGTCCACTCACTGTAAATTCAGTTTCTAATACGTTGGTAAAGCTGGCTTTCATCCAGCGGCCATCAGGTAGATCTTTCTTTTCTACAATATAACCTGTTATTTTGCTACCACCATCATAGGCAGGTT...
GATGTCGGCTTCAAGAACAAAAGTCTCTCCTGCATGAACAACGATGACATCTTTATATTTTGGATCCAGAGAGGCATTTGGTGCATCAATTTCATCTCTTGCAGTAATGGCACCACTACTATCAGATGGTTCACTAAAGTTTCCAGCTGCATTTCTTGCAATTACTCTAAATTCATATCTTTGGTCTTCTACAAGTCCACTCACTGTAAATTCAGTTTCTAATACGTTGGTAAAGCTGGCTTTCATCCAGCGGCCATCAGGTAGATCTTTCTTTTCTACAATATAACCTGTTATTTTGCTACCACCATCATAGGCAGGTT...
pathogenic
48,502
Regarding the variant found on chromosome 2 at position 178566309 in gene TTN: is it benign or pathogenic? If pathogenic, identify the disease(s).
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
CTCCTGCATGAACAACGATGACATCTTTATATTTTGGATCCAGAGAGGCATTTGGTGCATCAATTTCATCTCTTGCAGTAATGGCACCACTACTATCAGATGGTTCACTAAAGTTTCCAGCTGCATTTCTTGCAATTACTCTAAATTCATATCTTTGGTCTTCTACAAGTCCACTCACTGTAAATTCAGTTTCTAATACGTTGGTAAAGCTGGCTTTCATCCAGCGGCCATCAGGTAGATCTTTCTTTTCTACAATATAACCTGTTATTTTGCTACCACCATCATAGGCAGGTTTCTTCCATTTCAGTGTGACATTGTTT...
CTCCTGCATGAACAACGATGACATCTTTATATTTTGGATCCAGAGAGGCATTTGGTGCATCAATTTCATCTCTTGCAGTAATGGCACCACTACTATCAGATGGTTCACTAAAGTTTCCAGCTGCATTTCTTGCAATTACTCTAAATTCATATCTTTGGTCTTCTACAAGTCCACTCACTGTAAATTCAGTTTCTAATACGTTGGTAAAGCTGGCTTTCATCCAGCGGCCATCAGGTAGATCTTTCTTTTCTACAATATAACCTGTTATTTTGCTACCACCATCATAGGCAGGTTTCTTCCATTTCAGTGTGACATTGTTT...
pathogenic
48,503
Is the genetic change at chromosome 2, position 178566322, within gene TTN benign or pathogenic? Name the disease(s) if pathogenic.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AACGATGACATCTTTATATTTTGGATCCAGAGAGGCATTTGGTGCATCAATTTCATCTCTTGCAGTAATGGCACCACTACTATCAGATGGTTCACTAAAGTTTCCAGCTGCATTTCTTGCAATTACTCTAAATTCATATCTTTGGTCTTCTACAAGTCCACTCACTGTAAATTCAGTTTCTAATACGTTGGTAAAGCTGGCTTTCATCCAGCGGCCATCAGGTAGATCTTTCTTTTCTACAATATAACCTGTTATTTTGCTACCACCATCATAGGCAGGTTTCTTCCATTTCAGTGTGACATTGTTTCTTGTAATAACAA...
AACGATGACATCTTTATATTTTGGATCCAGAGAGGCATTTGGTGCATCAATTTCATCTCTTGCAGTAATGGCACCACTACTATCAGATGGTTCACTAAAGTTTCCAGCTGCATTTCTTGCAATTACTCTAAATTCATATCTTTGGTCTTCTACAAGTCCACTCACTGTAAATTCAGTTTCTAATACGTTGGTAAAGCTGGCTTTCATCCAGCGGCCATCAGGTAGATCTTTCTTTTCTACAATATAACCTGTTATTTTGCTACCACCATCATAGGCAGGTTTCTTCCATTTCAGTGTGACATTGTTTCTTGTAATAACAA...
pathogenic
48,505
Is the variant located on chromosome 2 at position 178566853, gene TTN, benign or pathogenic? If pathogenic, specify the disease(s) linked.
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AAGATGGTAGCCAATAATTTTGGTGCCTCCATCATTCACTGGCTCATGCCATTGCACAAGCATCTGATCTTTTGAGATTGATGTCACAAAAGGAGTTCCAGGTGGTCCAGGTTCTTTAAATGGATATTGTACAATAACTGCCTTAGAATCCAGTGGGGCACTTTTTCCATACCTGTTTTCAGCAAAAATTCTAAACTGGTACTCCGTGCCTGTTTTCAGTTTGGTTATTTTAATTGTTGTTCTTGCAACTGTTGCTGATACCATGTGCCAAGTGGTGGTGGTTGTATCTCGCTTCTCTACAATGTAGTTGCTTATTTGGC...
AAGATGGTAGCCAATAATTTTGGTGCCTCCATCATTCACTGGCTCATGCCATTGCACAAGCATCTGATCTTTTGAGATTGATGTCACAAAAGGAGTTCCAGGTGGTCCAGGTTCTTTAAATGGATATTGTACAATAACTGCCTTAGAATCCAGTGGGGCACTTTTTCCATACCTGTTTTCAGCAAAAATTCTAAACTGGTACTCCGTGCCTGTTTTCAGTTTGGTTATTTTAATTGTTGTTCTTGCAACTGTTGCTGATACCATGTGCCAAGTGGTGGTGGTTGTATCTCGCTTCTCTACAATGTAGTTGCTTATTTGGC...
pathogenic
48,532
Evaluate the clinical significance of the mutation at chromosome 2, position 178566986 in gene TTN: benign or pathogenic? What disease(s) does a pathogenic variant suggest?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
ATAACTGCCTTAGAATCCAGTGGGGCACTTTTTCCATACCTGTTTTCAGCAAAAATTCTAAACTGGTACTCCGTGCCTGTTTTCAGTTTGGTTATTTTAATTGTTGTTCTTGCAACTGTTGCTGATACCATGTGCCAAGTGGTGGTGGTTGTATCTCGCTTCTCTACAATGTAGTTGCTTATTTGGCAGCCACCAGTATAGGCTGGAGGTTCCCAAGATATGACTACAAAGTCTGCACTAACTTCATCAAACCGAACTGGGCCAACTGGAGGTCCAGGCTTTTCTAAAACGATAACACTGAGATTTTCTGTTGCTGTGCC...
ATAACTGCCTTAGAATCCAGTGGGGCACTTTTTCCATACCTGTTTTCAGCAAAAATTCTAAACTGGTACTCCGTGCCTGTTTTCAGTTTGGTTATTTTAATTGTTGTTCTTGCAACTGTTGCTGATACCATGTGCCAAGTGGTGGTGGTTGTATCTCGCTTCTCTACAATGTAGTTGCTTATTTGGCAGCCACCAGTATAGGCTGGAGGTTCCCAAGATATGACTACAAAGTCTGCACTAACTTCATCAAACCGAACTGGGCCAACTGGAGGTCCAGGCTTTTCTAAAACGATAACACTGAGATTTTCTGTTGCTGTGCC...
pathogenic
48,538
Is the genetic variant on chromosome 2, position 178567273, gene TTN, benign or pathogenic? If pathogenic, what disease(s) is indicated?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Dilated_cardiomyopathy_1G']
AACGATAACACTGAGATTTTCTGTTGCTGTGCCTGCACTATTTGTTGCCGTTACGGTGTATTTTCCAAAGTCATCTTTGTTACCTTCTTTAATGTGCAAAACAGTTGAGGTAGCTGTTTCTTCAACGTTTACTCTTGTTGTCTGTTTAAGAGGCTCACCATCTTTGACCCAAGAAATGTTAGGTCTTGGTCGGCCTATAACTGGAATTTCTATTTTAAGATCTTCTCCAGCTTGGATACTATATGTGTTAAATGGTAACTTTAAACTAGGCTGTATAGTCAAGTCCTTGGCTATGACAGGAACACCCAACACTCTTGGAT...
AACGATAACACTGAGATTTTCTGTTGCTGTGCCTGCACTATTTGTTGCCGTTACGGTGTATTTTCCAAAGTCATCTTTGTTACCTTCTTTAATGTGCAAAACAGTTGAGGTAGCTGTTTCTTCAACGTTTACTCTTGTTGTCTGTTTAAGAGGCTCACCATCTTTGACCCAAGAAATGTTAGGTCTTGGTCGGCCTATAACTGGAATTTCTATTTTAAGATCTTCTCCAGCTTGGATACTATATGTGTTAAATGGTAACTTTAAACTAGGCTGTATAGTCAAGTCCTTGGCTATGACAGGAACACCCAACACTCTTGGAT...
pathogenic
48,558
Regarding the variant at chromosome 2 and position 178567382, affecting gene TTN: benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Autosomal_recessive_limb-girdle_muscular_dystrophy_type_2J', 'Cardiovascular_phenotype', 'Dilated_cardiomyopathy_1G']
GTAGCTGTTTCTTCAACGTTTACTCTTGTTGTCTGTTTAAGAGGCTCACCATCTTTGACCCAAGAAATGTTAGGTCTTGGTCGGCCTATAACTGGAATTTCTATTTTAAGATCTTCTCCAGCTTGGATACTATATGTGTTAAATGGTAACTTTAAACTAGGCTGTATAGTCAAGTCCTTGGCTATGACAGGAACACCCAACACTCTTGGATCGCTTTTTCCTTTCTCATTATAAGCCTTGACACGGAACTGATATTCTTGTCCAGAACTCAAACCAGTAACAACTGCATTACAGACTTTGGATTCAGCCACAATGCTCCA...
GTAGCTGTTTCTTCAACGTTTACTCTTGTTGTCTGTTTAAGAGGCTCACCATCTTTGACCCAAGAAATGTTAGGTCTTGGTCGGCCTATAACTGGAATTTCTATTTTAAGATCTTCTCCAGCTTGGATACTATATGTGTTAAATGGTAACTTTAAACTAGGCTGTATAGTCAAGTCCTTGGCTATGACAGGAACACCCAACACTCTTGGATCGCTTTTTCCTTTCTCATTATAAGCCTTGACACGGAACTGATATTCTTGTCCAGAACTCAAACCAGTAACAACTGCATTACAGACTTTGGATTCAGCCACAATGCTCCA...
pathogenic
48,564
Regarding the variant at chromosome 2 and position 178567400, affecting gene TTN: benign or pathogenic? If pathogenic, what are the associated illness(es)?
pathogenic; ['Cardiovascular_phenotype', 'TTN-related_disorder']
TTTACTCTTGTTGTCTGTTTAAGAGGCTCACCATCTTTGACCCAAGAAATGTTAGGTCTTGGTCGGCCTATAACTGGAATTTCTATTTTAAGATCTTCTCCAGCTTGGATACTATATGTGTTAAATGGTAACTTTAAACTAGGCTGTATAGTCAAGTCCTTGGCTATGACAGGAACACCCAACACTCTTGGATCGCTTTTTCCTTTCTCATTATAAGCCTTGACACGGAACTGATATTCTTGTCCAGAACTCAAACCAGTAACAACTGCATTACAGACTTTGGATTCAGCCACAATGCTCCATTTTTCAGTTCCTTTGGG...
TTTACTCTTGTTGTCTGTTTAAGAGGCTCACCATCTTTGACCCAAGAAATGTTAGGTCTTGGTCGGCCTATAACTGGAATTTCTATTTTAAGATCTTCTCCAGCTTGGATACTATATGTGTTAAATGGTAACTTTAAACTAGGCTGTATAGTCAAGTCCTTGGCTATGACAGGAACACCCAACACTCTTGGATCGCTTTTTCCTTTCTCATTATAAGCCTTGACACGGAACTGATATTCTTGTCCAGAACTCAAACCAGTAACAACTGCATTACAGACTTTGGATTCAGCCACAATGCTCCATTTTTCAGTTCCTTTGGG...
pathogenic
48,566
Assess the variant on chromosome 2, position 178567507, impacting TTN: is it benign or pathogenic? If pathogenic, specify the associated condition(s).
pathogenic; ['Cardiomyopathy', 'Cardiovascular_phenotype']
GATACTATATGTGTTAAATGGTAACTTTAAACTAGGCTGTATAGTCAAGTCCTTGGCTATGACAGGAACACCCAACACTCTTGGATCGCTTTTTCCTTTCTCATTATAAGCCTTGACACGGAACTGATATTCTTGTCCAGAACTCAAACCAGTAACAACTGCATTACAGACTTTGGATTCAGCCACAATGCTCCATTTTTCAGTTCCTTTGGGCTGCATTTCAACAACGTACCCCAGGACTCTGCTACCGCCATCATGTTCAGGTTTCTCCCACATAAGTGATGCACTGGTCTGGGACACATCAGTGAGTGTAACCTTTC...
GATACTATATGTGTTAAATGGTAACTTTAAACTAGGCTGTATAGTCAAGTCCTTGGCTATGACAGGAACACCCAACACTCTTGGATCGCTTTTTCCTTTCTCATTATAAGCCTTGACACGGAACTGATATTCTTGTCCAGAACTCAAACCAGTAACAACTGCATTACAGACTTTGGATTCAGCCACAATGCTCCATTTTTCAGTTCCTTTGGGCTGCATTTCAACAACGTACCCCAGGACTCTGCTACCGCCATCATGTTCAGGTTTCTCCCACATAAGTGATGCACTGGTCTGGGACACATCAGTGAGTGTAACCTTTC...
pathogenic
48,571