Unnamed: 0
int64
0
41k
title
stringlengths
4
274
category
stringlengths
5
18
summary
stringlengths
22
3.66k
theme
stringclasses
8 values
10,000
A Method to Determine the In-Air Spatial Spread of Clinical Electron Beams
physics.med-ph
We propose and analyze in detail a method to measure the in-air spatial spread parameter of clinical electron beams. Measurements are performed at the center of the beam and below the adjustable collimators sited in asymmetrical configuration in order to avoid the distortions due to the presence of the applicator. The ...
physics
10,001
Assessing the risk from the depleted uranium weapons used in Operation Allied Force
physics.med-ph
The conflict in Yugoslavia has been a source of great concern due to the radiological and toxic hazard posed by the alleged presence of depleted uranium in NATO weapons. In the present study some worst-case scenaria are assumed in order to assess the risk for Yugoslavia and its neighboring countries . The risk is prove...
physics
10,002
The RR interval spectrum, the ECG signal and aliasing
physics.med-ph
A reliable spectral analysis requires sampling rate at least twice as large as the frequency bound, otherwise the analysis will be unreliable and plagued with aliasing distortions. The RR samplings do not satisfy the above requirements and therefore their spectral analysis might be unreliable. In order to demonstrate...
physics
10,003
Generalized Optimal Current Patterns and Electrical Safety in EIT
physics.med-ph
There are a number of constraints which limit the current and voltages which can be applied on a multiple drive electrical imaging system. One obvious constraint is to limit the maximum Ohmic power dissipated in the body. Current patterns optimising distinguishability with respect to this constraint are singular functi...
physics
10,004
Military use of depleted uranium: assessment of prolonged population exposure
physics.med-ph
This work is an exposure assessment for a population living in an area contaminated by use of depleted uranium (DU) weapons. RESRAD 5.91 code is used to evaluate the average effective dose delivered from 1, 10, 20 cm depths of contaminated soil, in a residential farmer scenario. Critical pathway and group are identifie...
physics
10,005
The Uncertainty Relationship In Magnetic Resonance Imaging (MRI)
physics.med-ph
The uncertainty relationship in MRI is shown. The result of uncertainty relationship is compared with other factors influencing the resolution of MRI. Our estimations show that the uncertainty relationship is of no significance in practice.
physics
10,006
A comparison of delayed radiobiological effects of depleted-uranium munitions versus fourth-generation nuclear weapons
physics.med-ph
It is shown that the radiological burden due to the battlefield use of circa 400 tons of depleted-uranium munitions in Iraq (and of about 40 tons in Yugoslavia) is comparable to that arising from the hypothetical battle-field use of more than 600 kt (respectively 60 kt) of high-explosive equivalent pure-fusion fourth-g...
physics
10,007
Non-linear quantization for arbitrary distributions and applications to Medical Image Processing
physics.med-ph
We report the development of a scalar quantization approach that helps build tables of decision and reconstruction levels for any probability density function (pdf). Several example pdf's are used for illustration: Uniform, Gaussian, Laplace, one-sided Rayleigh, and Gamma (One sided and double-sided symmetrical). The...
physics
10,008
Electron capture decay of indium-111 human carbonic anhydrase I: A time differential K X ray coincidence perturbed angular correlation study
physics.med-ph
The relaxation effects in the perturbed angular correlation spectra of indium-111 human carbonic anhydrase I (HCA I) are the result of chemical transmutation and/or the complex Auger cascades that follow the electron capture decay of indium-111. Time differential K X ray coincidence perturbed angular correlation (PAC) ...
physics
10,009
GPCALMA, a mammographic CAD in a GRID connection
physics.med-ph
Purpose of this work is the development of an automatic system which could be useful for radiologists in the investigation of breast cancer. A breast neoplasia is often marked by the presence of microcalcifications and massive lesions in the mammogram: hence the need for tools able to recognize such lesions at an early...
physics
10,010
A Computer Aided Detection system for mammographic images implemented on a GRID infrastructure
physics.med-ph
The use of an automatic system for the analysis of mammographic images has proven to be very useful to radiologists in the investigation of breast cancer, especially in the framework of mammographic-screening programs. A breast neoplasia is often marked by the presence of microcalcification clusters and massive lesions...
physics
10,011
Diagnostic performance of radiologists with and without different CAD systems for mammography
physics.med-ph
The purpose of this study is the evaluation of the variation of performance in terms of sensitivity and specificity of two radiologists with different experience in mammography, with and without the assistance of two different CAD systems. The CAD considered are SecondLookTM (CADx Medical Systems, Canada), and CALMA (C...
physics
10,012
The CALMA system: an artificial neural network method for detecting masses and microcalcifications in digitized mammograms
physics.med-ph
The CALMA (Computer Assisted Library for MAmmography) project is a five years plan developed in a physics research frame in collaboration between INFN (Istituto Nazionale di Fisica Nucleare) and many Italian hospitals. At present a large database of digitized mammographic images (more than 6000) was collected and a sof...
physics
10,013
Dosimetry for radiocolloid therapy of cystic craniopharyngiomas
physics.med-ph
The dosimetry for radiocolloid therapy of cystic craniopharyngiomas is investigated. Analytical calculations based on the Loevinger and the Berger formulae for electrons and photons, respectively, are compared with Monte Carlo simulations. The role of the material of which the colloid introduced inside the craniopharyn...
physics
10,014
EIT Reconstruction Algorithms: Pitfalls, Challenges and Recent Developments
physics.med-ph
We review developments, issues and challenges in Electrical Impedance Tomography (EIT), for the 4th Workshop on Biomedical Applications of EIT, Manchester 2003. We focus on the necessity for three dimensional data collection and reconstruction, efficient solution of the forward problem and present and future reconstruc...
physics
10,015
Dosimetry characterization of $^{32}$P intravascular brachytherapy source wires using Monte Carlo codes PENELOPE and GEANT4
physics.med-ph
Monte Carlo calculations using the codes PENELOPE and GEANT4 have been performed to characterize the dosimetric parameters of the new 20 mm long catheter based $^{32}$P beta source manufactured by Guidant Corporation. The dose distribution along the transverse axis and the two dimensional dose rate table have been calc...
physics
10,016
GePEToS : A Geant4 Monte Carlo simulation package for Positron Emission Tomography
physics.med-ph
GePEToS is a simulation framework developed over the last few years for assessing the instrumental performance of future PET scanners. It is based on Geant4, written in Object-Oriented C++ and runs on Linux platforms. The validity of GePEToS has been tested on the well-known Siemens ECAT EXACT HR+ camera. The results o...
physics
10,017
Algorithm and performance of a clinical IMRT beam-angle optimization system
physics.med-ph
This paper describes the algorithm and examines the performance of an IMRT beam-angle optimization (BAO) system. In this algorithm successive sets of beam angles are selected from a set of predefined directions using a fast simulated annealing (FSA) algorithm. An IMRT beam-profile optimization is performed on each gene...
physics
10,018
MRI of the lung using hyperpolarized He-3 at very low magnetic field (3 mT)
physics.med-ph
Optical pumping of He-3 produces large (hyper) nuclear-spin polarizations independent of the magnetic resonance imaging (MRI) field strength. This allows lung MRI to be performed at reduced fields with many associated benefits, such as lower tissue susceptibility gradients and decreased power absorption rates. Here we ...
physics
10,019
Stratification of the phase clouds and statistical effects of the non-Markovity in chaotic time series of human gait for healthy people and Parkinson patients
physics.med-ph
In this work we develop a new method of diagnosing the nervous system diseases and a new approach in studying human gait dynamics with the help of the theory of discrete non-Markov random processes. The stratification of the phase clouds and the statistical non-Markov effects in the time series of the dynamics of human...
physics
10,020
The influence of scattered photons on the accurate determination of microcalcification thickness in digital mammography
physics.med-ph
Our interest has been to study the effect that scattered radiation has on contrast, signal-to-noise ratio and thickness reconstruction in digital mammographies. Using the GEANT code we have performed Monte-Carlo simulations of 25 kVp Mo/Mo photons, through a breast phantom which contains a 0.2-1.0 mm thick microcalcifi...
physics
10,021
The impact of field shape optimization: A feasibility study
physics.med-ph
The impact of field shape optimization is studied for prostate type geometry. For this study, 76 and 81 Gy plans were generated. Dose distributions for wedged plans and Intensity Modulated (IM) plans for three and seven fields were compared for a quadratic cost function. For wedged plans, a Simulated Annealing Algorith...
physics
10,022
A simplified model of the source channel of the Leksell GammaKnife tested with PENELOPE
physics.med-ph
Monte Carlo simulations using the code PENELOPE have been performed to test a simplified model of the source channel geometry of the Leksell GammaKnife$^{\circledR}$. The characteristics of the radiation passing through the treatment helmets are analysed in detail. We have found that only primary particles emitted from...
physics
10,023
Radiostrontium activity concentrations in milk in the Republic of Croatia for 1961 - 2001 and dose assessment
physics.med-ph
Results of systematic measurements of Sr-90 activity concentrations in milk for the period 1961 - 2001 are summarized. An exponential decline of radioactivity followed the moratorium on atmospheric nuclear testing. The highest activity of Sr-90 deposited by fallout, being 1060 Bq/m2, was recorded in 1963, while the pea...
physics
10,024
Quantitative Approach to Intensity-Modulated Radiation Therapy Quality Assurance Based on Film Dosimetry and Optimization
physics.med-ph
To accurately verify the dose of intensity-modulated radiation therapy (IMRT), we have used a global optimization method to investigate a new dose-verification algorithm. In practical application of this quality assurance (QA) procedure, verification of the dose using calculated and measured dose distributions involves...
physics
10,025
A simplified model of the source channel of the Leksell Gamma Knife$^(R)$: testing multisource configurations with PENELOPE
physics.med-ph
A simplification of the source channel geometry of the Leksell Gamma Knife$^{\circledR}$, recently proposed by the authors and checked for a single source configuration (Al-Dweri et al 2004), has been used to calculate the dose distributions along the $x$, $y$ and $z$ axes in a water phantom with a diameter of 160~mm, ...
physics
10,026
Optimization and performance of an optical cardio-magnetometer
physics.med-ph
Cardiomagnetometry is a growing field of noninvasive medical diagnostics that has triggered a need for affordable high-sensitivity magnetometers. Optical pumping magnetometers are promising candidates satisfying that need since it was demonstrated that they can map the heart magnetic field. For the optimization of such...
physics
10,027
CADe tools for early detection of breast cancer
physics.med-ph
A breast neoplasia is often marked by the presence of microcalcifications and massive lesions in the mammogram: hence the need for tools able to recognize such lesions at an early stage. Our collaboration, among italian physicists and radiologists, has built a large distributed database of digitized mammographic images...
physics
10,028
GPCALMA: A Tool For Mammography With A GRID-Connected Distributed Database
physics.med-ph
The GPCALMA (Grid Platform for Computer Assisted Library for MAmmography) collaboration involves several departments of physics, INFN sections, and italian hospitals. The aim of this collaboration is developing a tool that can help radiologists in early detection of breast cancer. GPCALMA has built a large distributed ...
physics
10,029
GPCALMA: a Grid-based tool for Mammographic Screening
physics.med-ph
The next generation of High Energy Physics (HEP) experiments requires a GRID approach to a distributed computing system and the associated data management: the key concept is the Virtual Organisation (VO), a group of distributed users with a common goal and the will to share their resources. A similar approach is being...
physics
10,030
Effect of noise and modeling errors on the reliability of fully 3D Monte Carlo reconstruction in SPECT
physics.med-ph
We recently demonstrated the value of reconstructing SPECT data with fully 3D Monte Carlo reconstruction (F3DMC), in terms of spatial resolution and quantification. This was shown on a small cubic phantom (64 projections 10 x 10) in some idealistic configurations. The goals of the present study were to assess the effec...
physics
10,031
The effect of the primary collimator and flattening filter on asymmetric fields for a Siemens PRIMUS linear accelerator
physics.med-ph
Homogeneity for highly asymmetric fields has been studied for a Siemens PRIMUS linear accelerator. The flattening filter has a radius smaller than the primary collimator one, creating inhomogeneities that affect large fields in areas far from the collimator axis, and asymmetric fields with large offset. Profiles and ab...
physics
10,032
Polarized Helium to Image the Lung
physics.med-ph
The main findings of the european PHIL project (Polarised Helium to Image the Lung) are reported. State of the art optical pumping techniques for polarising ^3He gas are described. MRI methodological improvements allow dynamical ventilation images with a good resolution, ultimately limited by gas diffusion. Diffusion i...
physics
10,033
Pneumatic capillary gun for ballistic delivery of microparticles
physics.med-ph
A pneumatic gun for ballistic delivery of microparticles to soft targets is proposed and demonstrated. The particles are accelerated by a high speed flow of Helium in a capillary tube. Vacuum suction applied to a concentric, larger diameter tube is used to divert substantially all of the flow of Helium from the gun noz...
physics
10,034
Real time noninvasive cancer diagnostics
physics.med-ph
Laser illumination of tissue results in a characteristic fluorescence emission spectrum whose features depend on the type of tissue, viz., healthy, adenoma or malignant. Hence measurement of the fluorescence is potentially a rapid and reliable diagnostic method. We have applied the technique to thyroid tissues and foun...
physics
10,035
Preliminary study of metabolic radiotherapy with 188Re via small animal imaging
physics.med-ph
188Re is a beta- (Emax = 2.12 MeV) and gamma (155 keV) emitter. Since its chemistry is similar to that of the largely employed tracer, 99mTc, molecules of hyaluronic acid (HA) have been labelled with 188Re to produce a target specific radiopharmaceutical. The radiolabeled compound, i.v. injected in healthy mice, is abl...
physics
10,036
Performance of three-photon PET imaging: Monte Carlo simulations
physics.med-ph
We have recently introduced the idea of making use of three-photon positron annihilations in positron emission tomography. In this paper the basic characteristics of the three-gamma imaging in PET are studied by means of Monte Carlo simulations and analytical computations. Two typical configurations of human and small ...
physics
10,037
Nuclear Magnetic Resonance with the Distant Dipolar Field
physics.med-ph
Distant dipolar field (DDF)-based nuclear magnetic resonance is an active research area with many fundamental properties still not well understood. Already several intriguing applications have developed, like HOMOGENIZED and IDEAL spectroscopy, that allow high resolution spectra to be obtained in inhomogeneous fields, ...
physics
10,038
A pixel-based approach to massive lesion detection in X-ray mammography
physics.med-ph
A system for the automated detection of massive lesions in mammograms is presented. The approach we adopted is a pixel-based and multi-level one. Each pixel in a mammogram is flagged with the appropriate class membership, e.g. massive lesions or normal breast tissue.
physics
10,039
Pre-processing methods for nodule detection in lung CT
physics.med-ph
The use of automatic systems in the analysis of medical images has proven to be very useful to radiologists, especially in the framework of screening programs, in which radiologists make their first diagnosis on the basis of images only, most of those corresponding to healthy patients, and have to distinguish pathologi...
physics
10,040
Noise-induced first-order transition in anti-tumor immunotherapy
physics.med-ph
We studied the single-variable dynamics model of the tumor growth. A first-order phase transition induced by an additive noise is shown to reproduce the main features of tumor growth under immune surveillance. The critical average cells population has a power-law function relationship with the immune coefficient.
physics
10,041
Effects of bone- and air-tissue inhomogeneities on the dose distributions of the Leksell Gamma Knife$^{\circledR}$ calculated with PENELOPE
physics.med-ph
Monte Carlo simulation with PENELOPE (v.~2003) is applied to calculate Leksell Gamma Knife$^{\circledR}$ dose distributions for heterogeneous phantoms. The usual spherical water phantom is modified with a spherical bone shell simulating the skull and an air-filled cube simulating the frontal or maxillary sinuses. Diffe...
physics
10,042
Fully 3D Monte Carlo image reconstruction in SPECT using functional regions
physics.med-ph
Image reconstruction in Single Photon Emission Computed Tomography (SPECT) is affected by physical effects such as photon attenuation, Compton scatter and detector response. These effects can be compensated for by modeling the corresponding spread of photons in 3D within the system matrix used for tomographic reconstru...
physics
10,043
Experimental study of a liquid Xenon PET prototype module
physics.med-ph
A detector using liquid Xenon in the scintillation mode is studied for Positron Emission Tomography (PET). The specific design aims at taking full advantage of the liquid Xenon properties. It does feature a promising insensitive to any parallax effect. This work reports on the performances of the first LXe prototype mo...
physics
10,044
An Inexpensive Arterial Pressure Wave Sensor and its application in different physiological condition
physics.med-ph
Arterial Blood Pressure wave monitoring is considered to be important in assessment of cardiovascular system. We developed a novel pulse wave detection system using low frequency specific piezoelectric material as pressure wave sensor. The transducer detects the periodic change in the arterial wall diameter produced by...
physics
10,045
Physical basis of SATRO - a new method for analysis of the cardiac muscle depolarisation
physics.med-ph
On the basis of the model of the current flow through a single fibre, changes in the electric charge density over the myocardium are described. With the use of relevant analytic formulae, supported with numerical calculations, the distribution and time dependencies of electric potentials on the surface of the thorax ha...
physics
10,046
Niederhauser's model for epilepsy and wavelet methods
physics.med-ph
Wavelets and wavelet transforms (WT) could be a very useful tool to analyze electroencephalogram (EEG) signals. To illustrate the WT method we make use of a simple electric circuit model introduced by Niederhauser, which is used to produce EEG-like signals, particularly during an epileptic seizure. The original model i...
physics
10,047
Application of Unit Time Block Entropy to Fetal Distress Heart Rate
physics.med-ph
Recently, multiple time scale characteristics of heart dynamics have received much attention for distinguishing healthy and pathologic cardiac systems. Despite structural peculiarities of the fetal cardiovascular system, the fetal heart rate(FHR) displays multiple time scale characteristics similar to the adult heart r...
physics
10,048
Indoor-Atmospheric Radon-Related Radioactivity Affected by a Change of Ventilation Strategy
physics.med-ph
The present author has kept observation for concentrations of atmospheric radon, radon progeny and thoron progeny for several years at the campus of Fukushima Medical University. Accidentally, in the midst of an observation term, i.e., February 2005, the facility management group of the university changed a strategy fo...
physics
10,049
Computer assisted planning and orbital surgery: patient-related prediction of osteotomy size in proptosis reduction
physics.med-ph
BACKGROUND: Proptosis is characterized by a protrusion of the eyeball due to an increase of the orbital tissue volume. To recover a normal eyeball positioning, the most frequent surgical technique consists in the osteotomy of orbital walls combined with the manual loading on the eyeball. Only a rough clinical rule is c...
physics
10,050
Influences of tongue biomechanics on speech movements during the production of velar stop consonants: a modeling study
physics.med-ph
This study explores the following hypothesis: forward looping movements of the tongue that are observed in VCV sequences are due partly to the anatomical arrangement of the tongue muscles and how they are used to produce a velar closure. The study uses an anatomically based 2D biomechanical tongue model. Tissue elastic...
physics
10,051
Orbital and Maxillofacial Computer Aided Surgery: Patient-Specific Finite Element Models To Predict Surgical Outcomes
physics.med-ph
This paper addresses an important issue raised for the clinical relevance of Computer-Assisted Surgical applications, namely the methodology used to automatically build patient-specific Finite Element (FE) models of anatomical structures. From this perspective, a method is proposed, based on a technique called the Mesh...
physics
10,052
Prediction of tissue decompression in orbital surgery
physics.med-ph
Objective: A method to predict the relationships between decompressed volume of orbital soft tissues, backward displacement of globe after osteotomy, and force exerted by the surgeon, was proposed to improve surgery planning in exophthalmia reduction. Design: A geometric model and a poroelastic finite element model wer...
physics
10,053
Biomechanical models to simulate consequences of maxillofacial surgery
physics.med-ph
This paper presents the biomechanical finite element models that have been developed in the framework of the computer-assisted maxillofacial surgery. After a brief overview of the continuous elastic modelling method, two models are introduced and their use for computer-assisted applications discussed. The first model d...
physics
10,054
Computer-aided hepatic tumour ablation : requirements and preliminary results
physics.med-ph
Surgical resection of hepatic tumours is not always possible, since it depends on different factors, among which their location inside the liver functional segments. Alternative techniques consist in local use of chemical or physical agents to destroy the tumour. Radio frequency and cryosurgical ablations are examples ...
physics
10,055
A 3D dynamical biomechanical tongue model to study speech motor control
physics.med-ph
A 3D biomechanical dynamical model of human tongue is presented, that is elaborated in the aim to test hypotheses about speech motor control. Tissue elastic properties are accounted for in Finite Element Modeling (FEM). The FEM mesh was designed in order to facilitate the implementation of muscle arrangement within the...
physics
10,056
A simulator for maxillo-facial surgery integrating cephalometry and orthodontia
physics.med-ph
Objectives : This paper presents a new simulator for maxillo-facial surgery, that gathers the dental and the maxillo-facial analyses together into a single computer-assisted procedure. The idea is first to propose a repositioning of the maxilla, via the introduction of a 3D cephalometry, applied to a 3D virtual model o...
physics
10,057
Computer-aided hepatic tumour ablation
physics.med-ph
Surgical resection of hepatic tumours is not always possible. Alternative techniques consist in locally using chemical or physical agents to destroy the tumour and this may be performed percutaneously. It requires a precise localisation of the tumour placement during ablation. Computer-assisted surgery tools may be use...
physics
10,058
A finite element study of the influence of the osteotomy surface on the backward displacement during exophthalmia reduction
physics.med-ph
Exophthalmia is characterized by a protrusion of the eyeball. The most frequent surgery consists in an osteotomy of the orbit walls to increase the orbital volume and to retrieve a normal eye position. Only a few clinical obser-vations have estimated the relationship between the eyeball backward dis-placement and the d...
physics
10,059
Comparison of linear and non-linear soft tissue models with post-operative CT scan in maxillofacial surgery
physics.med-ph
A Finite Element model of the face soft tissue is proposed to simulate the morphological outcomes of maxillofacial surgery. Three modelling options are implemented: a linear elastic model with small and large deformation hypothesis, and an hyperelastic Mooney-Rivlin model. An evaluation procedure based on a qualitative...
physics
10,060
Physical modelling of the airflow-walls interactions to understand the sleep apnea syndrome
physics.med-ph
Sleep Apnea Syndrome (SAS) is defined as a partial or total closure of the patient upper airways during sleep. The term "collapsus" (or collapse) is used to describe this closure. From a fluid mechanical point of view, this collapse can be understood as a spectacular example of fluid-walls interaction. Indeed, the uppe...
physics
10,061
Models for Planning and Simulation in Computer Assisted Orthognatic Surgery
physics.med-ph
Two aspects required to establish a planning in orthognatic surgery are addressed in this paper. First, a 3D cephalometric analysis, which is clini-cally essential for the therapeutic decision. Then, an original method to build a biomechanical model of patient face soft tissue, which provides evaluation of the aestheti...
physics
10,062
Simulation of the Exophthalmia Reduction using a Finite Element Model of the Orbital Soft Tissues
physics.med-ph
This paper proposes a computer-assisted system for the surgical treatment of exophthalmia. This treatment is classically characterized by a de-compression of the orbit, by the mean of an orbital walls osteotomy. The plan-ning of this osteotomy consists in defining the size and the location of the de-compression hole. A...
physics
10,063
A 3D Finite Element model of the face for simulation in plastic and maxillo-facial surgery
physics.med-ph
This paper introduces a new Finite Element biomechanical model of the human face, which has been developed to be integrated into a simulator for plastic and maxillo-facial surgery. The idea is to be able to predict, from an aesthetic and functional point of view, the deformations of a patient face, resulting from repos...
physics
10,064
The mesh-matching algorithm: an automatic 3D mesh generator for Finite element structures
physics.med-ph
Several authors have employed Finite Element Analysis (FEA) for stress and strain analysis in orthopaedic biomechanics. Unfortunately, the use of three-dimensional models is time consuming and consequently the number of analysis to be performed is limited. The authors have investigated a new method allowing automatical...
physics
10,065
The geometric calibration of cone-beam imaging and delivery systems in radiation therapy
physics.med-ph
We propose a method to achieve the geometric calibration of cone-beam imaging and delivery systems in radiation therapy; our approach applies to devices where an X-ray source and a flat-panel detector, facing each other, move in circular orbits around the irradiated object. In order to extract the parameters of the geo...
physics
10,066
The dual-gain mode: a way to enhance the dynamic range of X-ray detectors
physics.med-ph
Varian Medical Systems has manufactured and recently put into operation a clinically-applicable solution for image-guided radiation therapy. Cone-beam CT imaging, one of the operation modes of the imaging unit of this device, aims at high-quality volumetric reconstruction. To boost the image quality, the dual-gain mode...
physics
10,067
The dual-dose imaging technique: a way to enhance the dynamic range of X-ray detectors
physics.med-ph
We describe a method aiming at increasing the dynamic range of X-ray detectors. Two X-ray exposures of an object are acquired at different dose levels and constitute the only input data. The values of the parameters which are needed to process these images are determined from information contained in the images themsel...
physics
10,068
Distributions of positron-emitting nuclei in proton and carbon-ion therapy studied with GEANT4
physics.med-ph
Depth distributions of positron-emitting nuclei in PMMA phantoms are calculated within a Monte Carlo model for Heavy-Ion Therapy (MCHIT) based on the GEANT4 toolkit (version 8.0). The calculated total production rates of $^{11}$C, $^{10}$C and $^{15}$O nuclei are compared with experimental data and with corresponding r...
physics
10,069
Growth Laws in Cancer: Implications for Radiotherapy
physics.med-ph
Comparing both, the more conventional Gompertz tumor growth law (GL) and the ``Universal'' law (UL), recently proposed and applied to cancer,we have investigated the growth law's implications on various radiotherapy regimen. According to GL, the surviving tumor cell fraction could be reduced 'ad libidum', independent...
physics
10,070
Improving human ankle joint position sense using an artificial tongue-placed tactile biofeedback
physics.med-ph
Proprioception is comprised of sensory input from several sources including muscle spindles, joint capsule, ligaments and skin. The purpose of the present experiment was to investigate whether the central nervous system was able to integrate an artificial biofeedback delivered through electrotactile stimulation of the ...
physics
10,071
Morphological Instability and Cancer Invasion: A 'Splashing Water Drop' Analogy
physics.med-ph
We present an analogy between two unrelated instabilities. One is caused by the impact of a drop of water on a solid surface while the other one concerns a tumor that develops invasive cellular branches into the surrounding host tissue. In spite of the apparent abstractness of the idea, it yields a very practical resul...
physics
10,072
Modeling the production of VCV sequences via the inversion of a biomechanical model of the tongue
physics.med-ph
A control model of the production of VCV sequences is presented, which consists in three main parts: a static forward model of the relations between motor commands and acoustic properties; the specification of targets in the perceptual space; a planning procedure based on optimization principles. Examples of simulation...
physics
10,073
Multimodal registration of the face for computer-aided maxillofacial surgery
physics.med-ph
This paper introduces a multimodal elastic registration algorithm applied to match a generic Finite Element model of the face to several patients morphologies. The method is automatic and appears to be accurate and robust. The computing time is compatible with clinical practice constraints.
physics
10,074
A stiffness sensor to help in the diagnosis and the surgery of orbital pathologies
physics.med-ph
Proptosis is characterized by a protrusion of the eyeball due to an increase of the orbital tissue volume. To recover a normal eyeball positioning, the most frequent surgical technique (BROD technique) consists in the osteotomy of orbital walls combined with a loading on the eyeball to initiate tissue decompression. In...
physics
10,075
Computer-aided planning for zygomatic bone reconstruction in maxillofacial traumatology
physics.med-ph
An optimal planning procedure has been proposed to define the target position of the zygomatic bone following a fracture of the mid-face skeleton. The protocol has been successfully tested on healthy subjects, and ensures the global symmetry of the face could be obtained after the reconstruction surgery. Now that the p...
physics
10,076
Automatic finite elements mesh generation from planar contours of the brain: an image driven 'blobby' approach
physics.med-ph
In this paper, we address the problem of automatic mesh generation for finite elements modeling of anatomical organs for which a volumetric data set is available. In the first step a set of characteristic outlines of the organ is defined manually or automatically within the volume. The outlines define the "key frames" ...
physics
10,077
Biomechanics applied to computer-aided diagnosis: examples of orbital and maxillofacial surgeries
physics.med-ph
This paper introduces the methodology proposed by our group to model the biological soft tissues deformations and to couple these models with Computer-Assisted Surgical (CAS) applications. After designing CAS protocols that mainly focused on bony structures, the Computer Aided Medical Imaging group of Laboratory TIMC (...
physics
10,078
A New Health Strategy to Prevent Pressure Ulcer Formation in Paraplegics using Computer and Sensory Substitution via the Tongue
physics.med-ph
Pressure ulcers are recognized as a major health issue in individuals with spinal cord injuries and new approaches to prevent this pathology are necessary. An innovative health strategy is being developed through the use of computer and sensory substitution via the tongue in order to compensate for the sensory loss in ...
physics
10,079
Framework and Bio-Mechanical Model for a Per-Operative Image-Guided Neuronavigator Including 'Brain-Shift' Compensation
physics.med-ph
In this paper we present a methodology to adress the problem of brain tissue deformation referred to as "brainshift". This deformation occurs throughout a neurosurgery intervention and strongly alters the accuracy of the neuronavigation systems used to date in clinical routine which rely solely on preoperative patient ...
physics
10,080
Modéliser le physique pour comprendre le contrôle : le cas de l'anticipation en production de parole
physics.med-ph
This chapter introduces numerical simulations provided by a 2D biomechanical model of the tongue. These simulations help in understanding the influence of the lingual mechanical characteristics onto the anticipation phenomena that are measured on acoustic and articulatory speech data.
physics
10,081
Evaluating soft tissue simulation in maxillofacial surgery using pre and post-operative CT scan
physics.med-ph
One of the most important issue in soft tissue modeling is to assess the quality of the simulations. A validation protocol is presented based on two CT scans of the patient acquired before and after cranio-maxillofacial surgery. The actual bones repositioning realized during the intervention are accurately measured and...
physics
10,082
Reproduction of hypopnea phenomenon using a physical and numerical model
physics.med-ph
Obstructive sleep apnea syndrome is now considered as a major health care topic. An in-vitro setup which reproduces and simplifies upper airway geometry has been the basis to study the fluid/walls interaction that leads to an apnea. It consists of a rigid pipe (the pharynx) in contact with a deformable latex cylinder f...
physics
10,083
Modélisation biomécanique tri-dimensionnelle de l'articulateur lingual pour étudier le contrôle de la parole
physics.med-ph
A 3D biomechanical dynamical model of human tongue is presented, which is elaborated to test in the future hypotheses about speech motor control. Tissue elastic properties are accounted for in Finite Element Modelling (FEM). The FEM mesh was designed in order to facilitate implementation of muscle arrangement in the to...
physics
10,084
Evaluation of a lingual interface as a passive surgical guiding system
physics.med-ph
Under conventional "open-" surgery, the physician has to take care of the patient, interact with other clinicians and check several monitoring devices. Nowadays, the Computer Assisted Surgery proposes to integrate 3D cameras in the operating theatre in order to assist the surgeon in performing minimal-invasive surgical...
physics
10,085
Maxillofacial computer aided surgery: a 5 years experience and future
physics.med-ph
This paper gives a review of the experience provided by our group in terms of computer aided maxillo-facial surgery.
physics
10,086
A 3D Finite Element evaluation of the exophthalmia reduction
physics.med-ph
This paper presents a first evaluation of the feasibility of Finite Element modelling of the orbital decompression, in the context of exophthalmia. First simulations are carried out with data extracted from a patient TDM exam. Results seem to qualitatively validate the feasibility of the simulations, with a Finite Elem...
physics
10,087
Percutaneous renal puncture: requirements and preliminary results
physics.med-ph
This paper introduces the principles of computer assisted percutaneous renal puncture, that would provide the surgeon with an accurate pre-operative 3D planning on CT images and, after a rigid registration with space-localized echographic data, would help him to perform the puncture through an intuitive 2D/3D interface...
physics
10,088
Computer aided planning for orthognatic surgery
physics.med-ph
A computer aided maxillofacial sequence is presented, applied to orthognatic surgery. It consists of 5 main stages: data acquisition and integration, surgical planning, surgical simulation, and per operative assistance. The planning and simulation steps are then addressed in a way that is clinically relevant. First con...
physics
10,089
Development and characteristics of the HANARO ex-core neutron irradiation facility for applications in the boron neutron capture therapy field
physics.med-ph
The HANARO ex-core neutron irradiation facility was developed for various applications in the boron neutron capture therapy (BNCT) field, and its characteristics have been investigated. In order to obtain a sufficient thermal neutron flux with a low level contamination of fast neutrons and gamma-rays, a radiation filte...
physics
10,090
Strong Memory in Time Series of Human Magnetoencephalograms Can Identify Photosensitive Epilepsy
physics.med-ph
To discuss the salient role of the statistical memory effects in the human brain functioning we have analyzed a set of stochastic memory quantifiers that reflects the dynamical characteristics of neuromagnetic brain responses to a flickering stimulus of different color combinations from a group of control subjects whic...
physics
10,091
Relaxation and phase space singularities in time series of human magnetoencephalograms as indicator of photosensitive epilepsy
physics.med-ph
To analyze the crucial role of fluctuation and relaxation effects for the function of the human brain we studied some statistical quantifiers that support the information characteristics of neuromagnetic brain responses (magnetoencephalogram, MEG). The signals to a flickering stimulus of different color combinations ha...
physics
10,092
Monte Carlo simulation of the electron transport through thin slabs: A comparative study of PENELOPE, GEANT3, GEANT4, EGSnrc and MCNPX
physics.med-ph
The Monte Carlo simulation of the electron transport through thin slabs is studied with five general purpose codes: PENELOPE, GEANT3, GEANT4, EGSnrc and MCNPX. The different material foils analyzed in the old experiments of Kulchitsky and Latyshev [Phys. Rev. 61 (1942) 254-266] and Hanson et al. [Phys. Rev. 84 (1951) 6...
physics
10,093
Dose distribution in water for monoenergetic photon point sources in the energy range of interest in brachytherapy: Monte Carlo simulations with PENELOPE and GEANT4
physics.med-ph
Monte Carlo calculations using the codes PENELOPE and GEANT4 have been performed to characterize the dosimetric properties of monoenergetic photon point sources in water. The dose rate in water has been calculated for energies of interest in brachytherapy, ranging between 10 keV and 2 MeV. A comparison of the results o...
physics
10,094
Demonstration of Circadian Rhythm in Heart Rate Turbulence using Novel Application of Correlator Functions
physics.med-ph
Background: It has been difficult to demonstrate circadian rhythm in the two parameters of heart rate turbulence, turbulence onset (TO) and turbulence slope (TS). Objective: To devise a new method for detecting circadian rhythm in noisy data, and apply it to selected Holter recordings from two post-myocardial infarct...
physics
10,095
A scalable Computer-Aided Detection system for microcalcification cluster identification in a pan-European distributed database of mammograms
physics.med-ph
A computer-aided detection (CADe) system for microcalcification cluster identification in mammograms has been developed in the framework of the EU-founded MammoGrid project. The CADe software is mainly based on wavelet transforms and artificial neural networks. It is able to identify microcalcifications in different ki...
physics
10,096
An Automatic System to Discriminate Malignant from Benign Massive Lesions on Mammograms
physics.med-ph
Mammography is widely recognized as the most reliable technique for early detection of breast cancers. Automated or semi-automated computerized classification schemes can be very useful in assisting radiologists with a second opinion about the visual diagnosis of breast lesions, thus leading to a reduction in the numbe...
physics
10,097
A scalable system for microcalcification cluster automated detection in a distributed mammographic database
physics.med-ph
A computer-aided detection (CADe) system for microcalcification cluster identification in mammograms has been developed in the framework of the EU-founded MammoGrid project. The CADe software is mainly based on wavelet transforms and artificial neural networks. It is able to identify microcalcifications in different da...
physics
10,098
Computer-aided detection of pulmonary nodules in low-dose CT
physics.med-ph
A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical CT images with 1.25 mm slice thickness is being developed in the framework of the INFN-supported MAGIC-5 Italian project. The basic modules of our lung-CAD system, a dot enhancement filter for nodule c...
physics
10,099
Lung Nodule Detection in Screening Computed Tomography
physics.med-ph
A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical Computed Tomography (CT) images with 1.25 mm slice thickness is presented. The basic modules of our lung-CAD system, a dot-enhancement filter for nodule candidate selection and a neural classifier for ...
physics