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10,700
Dynamical Equilibrium, trajectories study in an economical system. The case of the labor market
stat.AP
The paper deals with the study of labor market dynamics, and aims to characterize its equilibriums and possible trajectories. The theoretical background is the theory of the segmented labor market. The main idea is that this theory is well adapted to interpret the observed trajectories, due to the heterogeneity of the ...
statistics
10,701
Missing Data: A Comparison of Neural Network and Expectation Maximisation Techniques
stat.AP
The estimation of missing input vector elements in real time processing applications requires a system that possesses the knowledge of certain characteristics such as correlations between variables, which are inherent in the input space. Computational intelligence techniques and maximum likelihood techniques do possess...
statistics
10,702
An Integrated Human-Computer System for Controlling Interstate Disputes
stat.AP
In this paper we develop a scientific approach to control inter-country conflict. This system makes use of a neural network and a feedback control approach. It was found that by controlling the four controllable inputs: Democracy, Dependency, Allies and Capability simultaneously, all the predicted dispute outcomes coul...
statistics
10,703
Mixed models for longitudinal left-censored repeated measures
stat.AP
Longitudinal studies could be complicated by left-censored repeated measures. For example, in Human Immunodeficiency Virus infection, there is a detection limit of the assay used to quantify the plasma viral load. Simple imputation of the limit of the detection or of half of this limit for left-censored measures biases...
statistics
10,704
Finite Element Model Updating Using Bayesian Approach
stat.AP
This paper compares the Maximum-likelihood method and Bayesian method for finite element model updating. The Maximum-likelihood method was implemented using genetic algorithm while the Bayesian method was implemented using the Markov Chain Monte Carlo. These methods were tested on a simple beam and an unsymmetrical H-s...
statistics
10,705
Evaluating Throwing Ability in Baseball
stat.AP
We present a quantitative analysis of throwing ability for major league outfielders and catchers. We use detailed game event data to tabulate success and failure events in outfielder and catcher throwing opportunities. We attribute a run contribution to each success or failure which are tabulated for each player in eac...
statistics
10,706
Modeling Hourly Ozone Concentration Fields
stat.AP
This paper presents a dynamic linear model for modeling hourly ozone concentrations over the eastern United States. That model, which is developed within an Bayesian hierarchical framework, inherits the important feature of such models that its coefficients, treated as states of the process, can change with time. Thus ...
statistics
10,707
Controlling for individual heterogeneity in longitudinal models, with applications to student achievement
stat.AP
Longitudinal data tracking repeated measurements on individuals are highly valued for research because they offer controls for unmeasured individual heterogeneity that might otherwise bias results. Random effects or mixed models approaches, which treat individual heterogeneity as part of the model error term and use ge...
statistics
10,708
M-estimation of Boolean models for particle flow experiments
stat.AP
Probability models are proposed for passage time data collected in experiments with a device designed to measure particle flow during aerial application of fertilizer. Maximum likelihood estimation of flow intensity is reviewed for the simple linear Boolean model, which arises with the assumption that each particle req...
statistics
10,709
Does heterosexual transmission drive the HIV/AIDS epidemic in Sub-Saharan Africa (or elsewhere)?
stat.AP
A two-sex Basic Reproduction Number (BRN) is used to investigate the conditions under which the Human Immunodeficiency Virus (HIV) may spread through heterosexual contacts in Sub-Saharan Africa. (The BRN is the expected number of new infections generated by one infected individual; the disease spreads if the BRN is lar...
statistics
10,710
Application of probabilistic PCR5 Fusion Rule for Multisensor Target Tracking
stat.AP
This paper defines and implements a non-Bayesian fusion rule for combining densities of probabilities estimated by local (non-linear) filters for tracking a moving target by passive sensors. This rule is the restriction to a strict probabilistic paradigm of the recent and efficient Proportional Conflict Redistribution ...
statistics
10,711
An iterative tomogravity algorithm for the estimation of network traffic
stat.AP
This paper introduces an iterative tomogravity algorithm for the estimation of a network traffic matrix based on one snapshot observation of the link loads in the network. The proposed method does not require complete observation of the total load on individual edge links or proper tuning of a penalty parameter as exis...
statistics
10,712
A representative sampling plan for auditing health insurance claims
stat.AP
A stratified sampling plan to audit health insurance claims is offered. The stratification is by dollar amount of the claim. The plan is representative in the sense that with high probability for each stratum, the difference in the average dollar amount of the claim in the sample and the average dollar amount in the po...
statistics
10,713
Data selection and confounding in the court case of Lucia de Berk
stat.AP
The nurse Lucia de Berk was convicted by the Dutch courts as a serial killer with 7 murders and 3 attempts at murder in three hospitals where she worked. The nurse however always professed her innocence and indeed was never observed in such an act of murder. The courts based their decision on circumstantial evidence an...
statistics
10,714
Applied statistics: A review
stat.AP
The main phases of applied statistical work are discussed in general terms. The account starts with the clarification of objectives and proceeds through study design, measurement and analysis to interpretation. An attempt is made to extract some general notions.
statistics
10,715
A correlated topic model of Science
stat.AP
Topic models, such as latent Dirichlet allocation (LDA), can be useful tools for the statistical analysis of document collections and other discrete data. The LDA model assumes that the words of each document arise from a mixture of topics, each of which is a distribution over the vocabulary. A limitation of LDA is the...
statistics
10,716
Coupling hidden Markov models for the discovery of Cis-regulatory modules in multiple species
stat.AP
Cis-regulatory modules (CRMs) composed of multiple transcription factor binding sites (TFBSs) control gene expression in eukaryotic genomes. Comparative genomic studies have shown that these regulatory elements are more conserved across species due to evolutionary constraints. We propose a statistical method to combine...
statistics
10,717
A statistical approach to simultaneous mapping and localization for mobile robots
stat.AP
Mobile robots require basic information to navigate through an environment: they need to know where they are (localization) and they need to know where they are going. For the latter, robots need a map of the environment. Using sensors of a variety of forms, robots gather information as they move through an environment...
statistics
10,718
Random-set methods identify distinct aspects of the enrichment signal in gene-set analysis
stat.AP
A prespecified set of genes may be enriched, to varying degrees, for genes that have altered expression levels relative to two or more states of a cell. Knowing the enrichment of gene sets defined by functional categories, such as gene ontology (GO) annotations, is valuable for analyzing the biological signals in micro...
statistics
10,719
Elevated soil lead: Statistical modeling and apportionment of contributions from lead-based paint and leaded gasoline
stat.AP
While it is widely accepted that lead-based paint and leaded gasoline are primary sources of elevated concentrations of lead in residential soils, conclusions regarding their relative contributions are mixed and generally study specific. We develop a novel nonlinear regression for soil lead concentrations over time. It...
statistics
10,720
Of mice and men: Sparse statistical modeling in cardiovascular genomics
stat.AP
In high-throughput genomics, large-scale designed experiments are becoming common, and analysis approaches based on highly multivariate regression and anova concepts are key tools. Shrinkage models of one form or another can provide comprehensive approaches to the problems of simultaneous inference that involve implici...
statistics
10,721
Control of the mean number of false discoveries, Bonferroni and stability of multiple testing
stat.AP
The Bonferroni multiple testing procedure is commonly perceived as being overly conservative in large-scale simultaneous testing situations such as those that arise in microarray data analysis. The objective of the present study is to show that this popular belief is due to overly stringent requirements that are typica...
statistics
10,722
Spatial variation of total column ozone on a global scale
stat.AP
The spatial dependence of total column ozone varies strongly with latitude, so that homogeneous models (invariant to all rotations) are clearly unsuitable. However, an assumption of axial symmetry, which means that the process model is invariant to rotations about the Earth's axis, is much more plausible and considerab...
statistics
10,723
A resampling-based test to detect person-to-person transmission of infectious disease
stat.AP
Early detection of person-to-person transmission of emerging infectious diseases such as avian influenza is crucial for containing pandemics. We developed a simple permutation test and its refined version for this purpose. A simulation study shows that the refined permutation test is as powerful as or outcompetes the c...
statistics
10,724
Probabilistic projections of HIV prevalence using Bayesian melding
stat.AP
The Joint United Nations Programme on HIV/AIDS (UNAIDS) has developed the Estimation and Projection Package (EPP) for making national estimates and short-term projections of HIV prevalence based on observed prevalence trends at antenatal clinics. Assessing the uncertainty about its estimates and projections is importan...
statistics
10,725
A multivariate semiparametric Bayesian spatial modeling framework for hurricane surface wind fields
stat.AP
Storm surge, the onshore rush of sea water caused by the high winds and low pressure associated with a hurricane, can compound the effects of inland flooding caused by rainfall, leading to loss of property and loss of life for residents of coastal areas. Numerical ocean models are essential for creating storm surge for...
statistics
10,726
MOST: detecting cancer differential gene expression
stat.AP
We propose a new statistics for the detection of differentially expressed genes, when the genes are activated only in a subset of the samples. Statistics designed for this unconventional circumstance has proved to be valuable for most cancer studies, where oncogenes are activated for a small number of disease samples. ...
statistics
10,727
Estimation of Missing Data Using Computational Intelligence and Decision Trees
stat.AP
This paper introduces a novel paradigm to impute missing data that combines a decision tree with an auto-associative neural network (AANN) based model and a principal component analysis-neural network (PCA-NN) based model. For each model, the decision tree is used to predict search bounds for a genetic algorithm that m...
statistics
10,728
Timescale effect estimation in time-series studies of air pollution and health: A Singular Spectrum Analysis approach
stat.AP
A wealth of epidemiological data suggests an association between mortality/morbidity from pulmonary and cardiovascular adverse events and air pollution, but uncertainty remains as to the extent implied by those associations although the abundance of the data. In this paper we describe an SSA (Singular Spectrum Analysis...
statistics
10,729
Panel and Pseudo-Panel Estimation of Cross-Sectional and Time Series Elasticities of Food Consumption: The Case of American and Polish Data
stat.AP
The problem addressed in this article is the bias to income and expenditure elasticities estimated on pseudo-panel data caused by measurement error and unobserved heterogeneity. We gauge empirically these biases by comparing cross-sectional, pseudo-panel and true panel data from both Polish and American expenditure sur...
statistics
10,730
Decomposition of variance in terms of conditional means
stat.AP
We test against two different sets of data an apparently new approach to the analysis of the variance of a numerical variable which depends on qualitative characters. We suggest that this approach be used to complement other existing techniques to study the interdependence of the variables involved. According to our me...
statistics
10,731
Reliability of Module Based Software System
stat.AP
This paper consider the problem of determining the reliability of a software system which can be decomposed in a number of modules. We have derived the expression of the reliability of a system using the Markovian model for the transfer of control between modules in order. We have given the expression of reliability by...
statistics
10,732
Problems of Testology
stat.AP
Some problems of testology are discussed.
statistics
10,733
Interference Cancelation in Coherent CDMA Systems Using Parallel Iterative Algorithms
stat.AP
Least mean square-partial parallel interference cancelation (LMS-PPIC) is a partial interference cancelation using adaptive multistage structure in which the normalized least mean square (NLMS) adaptive algorithm is engaged to obtain the cancelation weights. The performance of the NLMS algorithm is mostly dependent to ...
statistics
10,734
Interference Cancelation in Non-coherent CDMA Systems Using Parallel Iterative Algorithms
stat.AP
Parallel least mean square-partial parallel interference cancelation (PLMS-PPIC) is a partial interference cancelation which employs adaptive multistage structure. In this algorithm the channel phases for all users are assumed to be known. Having only their quarters in (0,2\pi), a modified version of PLMS-PPIC is propo...
statistics
10,735
Full MIMO Channel Estimation Using A Simple Adaptive Partial Feedback Method
stat.AP
Partial feedback in multiple-input multiple-output (MIMO) communication systems provides tremendous capacity gain and enables the transmitter to exploit channel condition and to eliminate channel interference. In the case of severely limited feedback, constructing a quantized partial feedback is an important issue. To ...
statistics
10,736
Attrition and Non-Response in Panel Data: The Case of the Canadian Survey of Labor and Income Dynamics
stat.AP
This paper provides an analysis of the effects of attrition and non-response on employment and wages using the Canadian Survey of Labour and Income Dynamics. We consider a structural model composed of three freely correlated equations for nonattrition/response, employment and wages. The model is estimated using microda...
statistics
10,737
How to evaluate the calibration of a disease risk prediction tool
stat.AP
To evaluate the calibration of a disease risk prediction tool, the quantity $E/O$, i.e., the ratio of the expected number of events to the observed number of events, is generally computed. However, because of censoring, or more precisely because of individuals who drop out before the termination of the study, this quan...
statistics
10,738
Estimating exposure response functions using ambient pollution concentrations
stat.AP
This paper presents an approach to estimating the health effects of an environmental hazard. The approach is general in nature, but is applied here to the case of air pollution. It uses a computer model involving ambient pollution and temperature inputs, to simulate the exposures experienced by individuals in an urban ...
statistics
10,739
Pattern recognition on random trees associated to protein functionality families
stat.AP
In this paper, we address the problem of identifying protein functionality using the information contained in its aminoacid sequence. We propose a method to define sequence similarity relationships that can be used as input for classification and clustering via well known metric based statistical methods. In our exampl...
statistics
10,740
Residual-based localization and quantification of peaks in x-ray diffractograms
stat.AP
We consider data consisting of photon counts of diffracted x-ray radiation as a function of the angle of diffraction. The problem is to determine the positions, powers and shapes of the relevant peaks. An additional difficulty is that the power of the peaks is to be measured from a baseline which itself must be identif...
statistics
10,741
MCMC Inference for a Model with Sampling Bias: An Illustration using SAGE data
stat.AP
This paper explores Bayesian inference for a biased sampling model in situations where the population of interest cannot be sampled directly, but rather through an indirect and inherently biased method. Observations are viewed as being the result of a multinomial sampling process from a tagged population which is, in t...
statistics
10,742
Comparison of Spline with Kriging in an Epidemiological Problem
stat.AP
There are various methods to analyze different kinds of data sets. Spatial data is defined when data is dependent on each other based on their respective locations. Spline and Kriging are two methods for interpolating and predicting spatial data. Under certain conditions, these methods are equivalent, but in practice t...
statistics
10,743
A practical illustration of the importance of realistic individualized treatment rules in causal inference
stat.AP
The effect of vigorous physical activity on mortality in the elderly is difficult to estimate using conventional approaches to causal inference that define this effect by comparing the mortality risks corresponding to hypothetical scenarios in which all subjects in the target population engage in a given level of vigor...
statistics
10,744
Editorial: Statistics and forensic science
stat.AP
Forensic science is usually taken to mean the application of a broad spectrum of scientific tools to answer questions of interest to the legal system. Despite such popular television series as CSI: Crime Scene Investigation and its spinoffs--CSI: Miami and CSI: New York--on which the forensic scientists use the latest ...
statistics
10,745
The rarity of DNA profiles
stat.AP
It is now widely accepted that forensic DNA profiles are rare, so it was a surprise to some people that different people represented in offender databases are being found to have the same profile. In the first place this is just an illustration of the birthday problem, but a deeper analysis must take into account depen...
statistics
10,746
Interpretation of interaction: A review
stat.AP
Several different types of statistical interaction are defined and distinguished, primarily on the basis of the nature of the factors defining the interaction. Illustrative examples, mostly epidemiological, are given. The emphasis is primarily on interpretation rather than on methods for detecting interactions.
statistics
10,747
The pigeonhole bootstrap
stat.AP
Recently there has been much interest in data that, in statistical language, may be described as having a large crossed and severely unbalanced random effects structure. Such data sets arise for recommender engines and information retrieval problems. Many large bipartite weighted graphs have this structure too. We woul...
statistics
10,748
A statistical analysis of memory CD8 T cell differentiation: An application of a hierarchical state space model to a short time course microarray experiment
stat.AP
CD8 T cells are specialized immune cells that play an important role in the regulation of antiviral immune response and the generation of protective immunity. In this paper we investigate the differentiation of memory CD8 T cells in the immune response using a short time course microarray experiment. Structurally, this...
statistics
10,749
Curve alignment by moments
stat.AP
A significant problem with most functional data analyses is that of misaligned curves. Without adjustment, even an analysis as simple as estimation of the mean will fail. One common method to synchronize a set of curves involves equating ``landmarks'' such as peaks or troughs. The landmarks method can work well but wil...
statistics
10,750
Accounting for spatial correlation in the scan statistic
stat.AP
The spatial scan statistic is widely used in epidemiology and medical studies as a tool to identify hotspots of diseases. The classical spatial scan statistic assumes the number of disease cases in different locations have independent Poisson distributions, while in practice the data may exhibit overdispersion and spat...
statistics
10,751
Crossing paths in 2D Random Walks
stat.AP
We investigate crossing path probabilities for two agents that move randomly in a bounded region of the plane or on a sphere (denoted $R$). At each discrete time-step the agents move, independently, fixed distances $d_1$ and $d_2$ at angles that are uniformly distributed in $(0,2\pi)$. If $R$ is large enough and the in...
statistics
10,752
Correction: A correlated topic model of Science
stat.AP
Correction to Annals of Applied Statistics 1 (2007) 17--35 [doi:10.1214/07-AOAS114]
statistics
10,753
Improving population-specific allele frequency estimates by adapting supplemental data: an empirical Bayes approach
stat.AP
Estimation of the allele frequency at genetic markers is a key ingredient in biological and biomedical research, such as studies of human genetic variation or of the genetic etiology of heritable traits. As genetic data becomes increasingly available, investigators face a dilemma: when should data from other studies an...
statistics
10,754
The BARISTA: A model for bid arrivals in online auctions
stat.AP
The arrival process of bidders and bids in online auctions is important for studying and modeling supply and demand in the online marketplace. A popular assumption in the online auction literature is that a Poisson bidder arrival process is a reasonable approximation. This approximation underlies theoretical derivation...
statistics
10,755
A statistical framework for the analysis of microarray probe-level data
stat.AP
In microarray technology, a number of critical steps are required to convert the raw measurements into the data relied upon by biologists and clinicians. These data manipulations, referred to as preprocessing, influence the quality of the ultimate measurements and studies that rely upon them. Standard operating procedu...
statistics
10,756
Describing disability through individual-level mixture models for multivariate binary data
stat.AP
Data on functional disability are of widespread policy interest in the United States, especially with respect to planning for Medicare and Social Security for a growing population of elderly adults. We consider an extract of functional disability data from the National Long Term Care Survey (NLTCS) and attempt to devel...
statistics
10,757
Diverse correlation structures in gene expression data and their utility in improving statistical inference
stat.AP
It is well known that correlations in microarray data represent a serious nuisance deteriorating the performance of gene selection procedures. This paper is intended to demonstrate that the correlation structure of microarray data provides a rich source of useful information. We discuss distinct correlation substructur...
statistics
10,758
Chemical and forensic analysis of JFK assassination bullet lots: Is a second shooter possible?
stat.AP
The assassination of President John Fitzgerald Kennedy (JFK) traumatized the nation. In this paper we show that evidence used to rule out a second assassin is fundamentally flawed. This paper discusses new compositional analyses of bullets reportedly to have been derived from the same batch as those used in the assassi...
statistics
10,759
On the Empirical Importance of the Conditional Skewness Assumption in Modelling the Relationship Between Risk and Return
stat.AP
The main goal of this paper is an application of Bayesian inference in testing the relation between risk and return on the financial instruments. On the basis of the Intertemporal CAPM model we built a general sampling model suitable in analysing such a relationship. The most important feature of our assumptions is tha...
statistics
10,760
Bilinear Mixed Effects Models For Relations Between Universities
stat.AP
this article illustrates the use of linear and bilinear random effects models to represent statistical dependencies that often characterize dyadic data such as international relations. In particular, we show how to estimate models for dyadic data that simultaneously take into account: regressor variables and third-orde...
statistics
10,761
A preferential attachment model with Poisson growth for scale-free networks
stat.AP
We propose a scale-free network model with a tunable power-law exponent. The Poisson growth model, as we call it, is an offshoot of the celebrated model of Barab\'{a}si and Albert where a network is generated iteratively from a small seed network; at each step a node is added together with a number of incident edges pr...
statistics
10,762
Markovian Memory Embedded in Two-State Natural Processes
stat.AP
Markovian memory embedded in a binary system is shaping its evolution on the basis of its current state and introduces either clustering or dispersion of binary states. The consequence is directly observed in the lengthening or shortening of the runs of the same binary state and also in the way the proportion of a stat...
statistics
10,763
The Inverse Simpson Paradox (How To Win Without Overtly Cheating)
stat.AP
Given two sets of data which lead to a similar statistical conclusion, the Simpson Paradox describes the tactic of combining these two sets and achieving the opposite conclusion. Depending upon the given data, this may or may not succeed. Inverse Simpson is a method of decomposing a given set of comparison data into tw...
statistics
10,764
A regional Bayesian POT model for flood frequency analysis
stat.AP
Flood frequency analysis is usually based on the fitting of an extreme value distribution to the local streamflow series. However, when the local data series is short, frequency analysis results become unreliable. Regional frequency analysis is a convenient way to reduce the estimation uncertainty. In this work, we pro...
statistics
10,765
Modeling All Exceedances Above a Threshold Using an Extremal Dependence Structure: Inferences on Several Flood Characteristics
stat.AP
Flood quantile estimation is of great importance for many engineering studies and policy decisions. However, practitioners must often deal with small data available. Thus, the information must be used optimally. In the last decades, to reduce the waste of data, inferential methodology has evolved from annual maxima mod...
statistics
10,766
Usefulness of the Reversible Jump Markov Chain Monte Carlo Model in Regional Flood Frequency Analysis
stat.AP
Regional flood frequency analysis is a convenient way to reduce estimation uncertainty when few data are available at the gauging site. In this work, a model that allows a non-null probability to a regional fixed shape parameter is presented. This methodology is integrated within a Bayesian framework and uses reversibl...
statistics
10,767
Causal Models for Estimating the Effects of Weight Gain on Mortality
stat.AP
Suppose, contrary to fact, in 1950, we had put the cohort of 18 year old non-smoking American men on a stringent mandatory diet that guaranteed that no one would ever weigh more than their baseline weight established at age 18. How would the counter-factual mortality of these 18 year olds have compared to their actual ...
statistics
10,768
Homoscedastic controlled calibration model
stat.AP
In the context of the usual calibration model, we consider the case in which the independent variable is unobservable, but a pre-fixed value on its surrogate is available. Thus, considering controlled variables and assuming that the measurement errors have equal variances we propose a new calibration model. Likelihood ...
statistics
10,769
An efficient methodology for modeling complex computer codes with Gaussian processes
stat.AP
Complex computer codes are often too time expensive to be directly used to perform uncertainty propagation studies, global sensitivity analysis or to solve optimization problems. A well known and widely used method to circumvent this inconvenience consists in replacing the complex computer code by a reduced model, call...
statistics
10,770
Testing polynomial covariate effects in linear and generalized linear mixed models
stat.AP
An important feature of linear mixed models and generalized linear mixed models is that the conditional mean of the response given the random effects, after transformed by a link function, is linearly related to the fixed covariate effects and random effects. Therefore, it is of practical importance to test the adequac...
statistics
10,771
PGA Tour Scores as a Gaussian Random Variable
stat.AP
In this paper it is demonstrated that the scoring at each PGA Tour stroke play event can be reasonably modeled as a Gaussian random variable. All 46 stroke play events in the 2007 season are analyzed. The distributions of scores are favorably compared with a Gaussian distribution using the Kolmogorov-Smirnov test. This...
statistics
10,772
Bayesball: A Bayesian hierarchical model for evaluating fielding in major league baseball
stat.AP
The use of statistical modeling in baseball has received substantial attention recently in both the media and academic community. We focus on a relatively under-explored topic: the use of statistical models for the analysis of fielding based on high-resolution data consisting of on-field location of batted balls. We co...
statistics
10,773
Statistical aspects of birth--and--growth stochastic processes
stat.AP
The paper considers a particular family of set--valued stochastic processes modeling birth--and--growth processes. The proposed setting allows us to investigate the nucleation and the growth processes. A decomposition theorem is established to characterize the nucleation and the growth. As a consequence, different cons...
statistics
10,774
Influence of Speed Limit on Roadway Safety in Indiana
stat.AP
The influence of speed limits on roadway safety is an extremely important social issue and is subject to an extensive debate in the State of Indiana and nationwide. With around 800-900 fatalities and thousands of injuries annually in Indiana, traffic accidents place an incredible social and economic burden on the state...
statistics
10,775
Editorial: Statistics and "The lost tomb of Jesus"
stat.AP
What makes a problem suitable for statistical analysis? Are historical and religious questions addressable using statistical calculations? Such issues have long been debated in the statistical community and statisticians and others have used historical information and texts to analyze such questions as the economics of...
statistics
10,776
In-season prediction of batting averages: A field test of empirical Bayes and Bayes methodologies
stat.AP
Batting average is one of the principle performance measures for an individual baseball player. It is natural to statistically model this as a binomial-variable proportion, with a given (observed) number of qualifying attempts (called ``at-bats''), an observed number of successes (``hits'') distributed according to the...
statistics
10,777
False discovery rate analysis of brain diffusion direction maps
stat.AP
Diffusion tensor imaging (DTI) is a novel modality of magnetic resonance imaging that allows noninvasive mapping of the brain's white matter. A particular map derived from DTI measurements is a map of water principal diffusion directions, which are proxies for neural fiber directions. We consider a study in which diffu...
statistics
10,778
On regression adjustments in experiments with several treatments
stat.AP
Regression adjustments are often made to experimental data. Since randomization does not justify the models, bias is likely; nor are the usual variance calculations to be trusted. Here, we evaluate regression adjustments using Neyman's nonparametric model. Previous results are generalized, and more intuitive proofs are...
statistics
10,779
Simultaneous inference: When should hypothesis testing problems be combined?
stat.AP
Modern statisticians are often presented with hundreds or thousands of hypothesis testing problems to evaluate at the same time, generated from new scientific technologies such as microarrays, medical and satellite imaging devices, or flow cytometry counters. The relevant statistical literature tends to begin with the ...
statistics
10,780
Sparse estimation of large covariance matrices via a nested Lasso penalty
stat.AP
The paper proposes a new covariance estimator for large covariance matrices when the variables have a natural ordering. Using the Cholesky decomposition of the inverse, we impose a banded structure on the Cholesky factor, and select the bandwidth adaptively for each row of the Cholesky factor, using a novel penalty we ...
statistics
10,781
Skip sequencing: A decision problem in questionnaire design
stat.AP
This paper studies questionnaire design as a formal decision problem, focusing on one element of the design process: skip sequencing. We propose that a survey planner use an explicit loss function to quantify the trade-off between cost and informativeness of the survey and aim to make a design choice that minimizes los...
statistics
10,782
Coordinate descent algorithms for lasso penalized regression
stat.AP
Imposition of a lasso penalty shrinks parameter estimates toward zero and performs continuous model selection. Lasso penalized regression is capable of handling linear regression problems where the number of predictors far exceeds the number of cases. This paper tests two exceptionally fast algorithms for estimating re...
statistics
10,783
A statistical framework for testing functional categories in microarray data
stat.AP
Ready access to emerging databases of gene annotation and functional pathways has shifted assessments of differential expression in DNA microarray studies from single genes to groups of genes with shared biological function. This paper takes a critical look at existing methods for assessing the differential expression ...
statistics
10,784
Accounting for self-protective responses in randomized response data from a social security survey using the zero-inflated Poisson model
stat.AP
In 2004 the Dutch Department of Social Affairs conducted a survey to assess the extent of noncompliance with social security regulations. The survey was conducted among 870 recipients of social security benefits and included a series of sensitive questions about regulatory noncompliance. Due to the sensitive nature of ...
statistics
10,785
Transcription factor binding site prediction with multivariate gene expression data
stat.AP
Multi-sample microarray experiments have become a standard experimental method for studying biological systems. A frequent goal in such studies is to unravel the regulatory relationships between genes. During the last few years, regression models have been proposed for the de novo discovery of cis-acting regulatory seq...
statistics
10,786
Optimal factorial designs for cDNA microarray experiments
stat.AP
We consider cDNA microarray experiments when the cell populations have a factorial structure, and investigate the problem of their optimal designing under a baseline parametrization where the objects of interest differ from those under the more common orthogonal parametrization. First, analytical results are given for ...
statistics
10,787
Assessing surrogate endpoints in vaccine trials with case-cohort sampling and the Cox model
stat.AP
Assessing immune responses to study vaccines as surrogates of protection plays a central role in vaccine clinical trials. Motivated by three ongoing or pending HIV vaccine efficacy trials, we consider such surrogate endpoint assessment in a randomized placebo-controlled trial with case-cohort sampling of immune respons...
statistics
10,788
A hidden spatial-temporal Markov random field model for network-based analysis of time course gene expression data
stat.AP
Microarray time course (MTC) gene expression data are commonly collected to study the dynamic nature of biological processes. One important problem is to identify genes that show different expression profiles over time and pathways that are perturbed during a given biological process. While methods are available to ide...
statistics
10,789
Letter to the editor. NAA and JFK: Can revisionism take us home?
stat.AP
Occasionally during the course of the human learning experience we are faced with an anomaly. An aberration of sorts, which try as we might, defies appropriate classification. The recent paper by Spiegelman et al.--Chemical and forensic analysis of JFK assassination bullet lots: Is a second shooter possible?--is one su...
statistics
10,790
Response to the Letter to the Editor
stat.AP
This paper has attracted interest around the world from the media (both TV and newspapers). In addition, we have received letters, emails and telephone calls. One of our favorites was a voicemail message asking us to return a call to Australia at which point we would learn who really killed JFK. We welcome the opportun...
statistics
10,791
Statistical advances and challenges for analyzing correlated high dimensional SNP data in genomic study for complex diseases
stat.AP
Recent advances of information technology in biomedical sciences and other applied areas have created numerous large diverse data sets with a high dimensional feature space, which provide us a tremendous amount of information and new opportunities for improving the quality of human life. Meanwhile, great challenges are...
statistics
10,792
Statistical analysis of an archeological find
stat.AP
In 1980, a burial tomb was unearthed in Jerusalem containing ossuaries (limestone coffins) bearing such inscriptions as Yeshua son of Yehosef, Marya, Yoseh--names which match those of New Testament (NT) figures, but were otherwise in common use. This paper discusses certain statistical aspects of authenticating or repu...
statistics
10,793
Discussion of: Statistical analysis of an archeological find
stat.AP
Discussion of ``Statistical analysis of an archeological find'' by Andrey Feuerverger [arXiv:0804.0079]
statistics
10,794
Discussion of: Statistical analysis of an archeological find
stat.AP
Discussion of ``Statistical analysis of an archeological find'' by Andrey Feuerverger [arXiv:0804.0079]
statistics
10,795
Discussion of: Statistical analysis of an archaeological find
stat.AP
Discussion of ``Statistical analysis of an archeological find'' by Andrey Feuerverger [arXiv:0804.0079]
statistics
10,796
Discussion of: Statistical analysis of an archeological find--skeptical counting challenges to an archaeological find
stat.AP
Discussion of ``Statistical analysis of an archeological find'' by Andrey Feuerverger [arXiv:0804.0079]
statistics
10,797
Discussion of: Statistical analysis of an archeological find
stat.AP
Discussion of ``Statistical analysis of an archeological find'' by Andrey Feuerverger [arXiv:0804.0079]
statistics
10,798
Discussion of: Statistical analysis of an archaeological find
stat.AP
We critique the analysis by A. Feuerverger of an archaeological find [arXiv:0804.0079] that has been alleged by some to be the tomb of Jesus of Nazareth. We show that his analysis rests on six faulty assumptions that have been severely criticized by historians, archaeologists, and scholars in related disciplines. We su...
statistics
10,799
Discussion of: Statistical analysis of an archeological find
stat.AP
Discussion of ``Statistical analysis of an archeological find'' by Andrey Feuerverger [arXiv:0804.0079]
statistics