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"anxiety affects quality of life in those living with parkinson 's disease ( pd ) more so than overall cognitive status , motor deficits , apathy , and depression [ 13 ] . although anxiety and depression are often related and coexist in pd patients , recent research suggests that anxiety rather than depression is t... | research on the implications of anxiety in parkinson 's disease ( pd ) has been neglected despite its prevalence in nearly 50% of patients and its negative impact on quality of life . previous reports have noted that neuropsychiatric symptoms impair cognitive performance in pd patients ; however , to date , no study has directly compared pd patients with and without anxiety to examine the impact of anxiety on cognitive impairments in pd . this study compared cognitive performance across 50 pd participants with and without anxiety ( 17 pda+ ; 33 pda ) , who underwent neurological and neuropsychological assessment . group performance was compared across the following cognitive domains : simple attention / visuomotor processing speed , executive function ( e.g. , set - shifting ) , working memory , language , and memory / new verbal learning . results showed that pda+ performed significantly worse on the digit span forward and backward test and part b of the trail making task ( tmt - b ) compared to the pda group . there were no group differences in verbal fluency , logical memory , or tmt - a performance . in conclusion , anxiety in pd has a measurable impact on working memory and attentional set - shifting . |
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"small non - coding rnas are transcribed into mrna but remain untranslated in eukaryotic cells . they include sirna ( small interfering rna ) , mirna ( microrna ) , pirna ( piwi - interacting rna ) and snorna ( small nucleolar rna ) . mirnas are a class of multifunctional singled - stranded small rna which are ~20 ... | small non - coding rnas include sirna , mirna , pirna and snorna . the involvement of mirnas in the regulation of mammary gland tumorigenesis has been widely studied while the role for other small non - coding rnas remains unclear . here we summarize the involvement of mirna in breast cancer onset and progression through regulating the cell cycle and cellular proliferation . the regulation of breast cancer stem cells and tumor regeneration by mirna is reviewed . in addition , the emerging evidence demonstrating the involvement of pirna and snorna in breast cancer is briefly described . |
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"ohss is a serious complication of ovulation induction , occurring in 1 - 10% of in vitro fertilization patients ( rizk and aboulghar , 1991 ; brinsden et al . , 1995 ) . this iatrogenic condition has a spectrum of clinical and laboratory manifestations ranging from mild to severe , even life - threatening conditi... | objective : to evaluate the efficacy and safety of outpatient management of severe ovarian hyperstimulation syndrome ( ohss ) requiring placement of a pigtail catheter.methods : retrospective analysis of thirty - three consecutive patients who underwent in - vitro fertilization ( 2003 - 2009 ) and developed severe / critical ohss requiring placement of a pigtail catheter . patients who were managed on outpatient basis were monitored by frequent office visits , daily phone calls , and received iv normal saline for hydration when required.results : in 3 patients ( 9.1% ) ohss started early , requiring placement of a pigtail catheter 4.3 + 0.6 days after retrieval . in 30 patients ( 90.9% ) ohss started late ( 14 4 days after retrieval ) . the mean amount of ascitic fluid drained immediately after placement of the catheter was 2085 1018 cc . the pigtail catheter was removed after 7.8 5.3 days . of the 31 patients who had embryo transfer ( two had total freeze ) , 84% conceived . twenty - nine patients ( 88% ) were managed on outpatient basis without any complications . four patients required hospital admission for 1 - 7 days ( 3.0 2.7 ) . one patient with severe ohss was admitted for work up for chest pain . three patients with critical ohss with severe pleural effusion requiring thoracentesis were admitted for supportive measures.conclusion : the placement of a pigtail catheter resulted in safe and effective outpatient management for the majority of patients with severe ohss . |
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"congenital adrenal hyperplasia ( cah ) refers to a group of autosomal recessive disorders caused by an enzyme deficiency which leads to defects in biosynthesis of steroid precursors . depending on the severity and degree of 21 hydroxylase deficiency , the clinical spectrum may vary from mild form of non classical ... | congenital adrenal hyperplasia is a group of autosomal recessive disorders caused by enzyme deficiency which leads to defects in biosynthesis of steroid precursors . most common is 21 hydroxylase deficiency . clinical spectrum varies from non - classical cah to classic cah , and it may be simple virilising form or salt - wastinfg type . 29 patients were included in our study from january 2012 to october 2012 . 76% were females . male babies typically presented with adrenal crisis between 3rd to 6th week of life . around 20% of females were identified and appropriately treated only after late adolescence . short stature was seen in 1/3rd of patients . 1/3rd of patients had suppressed 17 ohp levels suggestive of over - replacement therapy which may contribute to final reduction in adult height . |
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"type 1 diabetes ( t1d ) results from the destruction of insulin producing pancreatic cells by a cell specific autoimmune process ( 1 ) . chronic pancreatic inflammation ( insulitis ) and destruction of islet -cells in type 1 diabetes is mediated by the immune cells , particularly autoreactive cd4 and cd8 t lymph... | objective(s):pentoxifylline is an immunomodulatory and anti - inflammatory agent and is used in vascular disorders . it has been shown that pentoxifylline inhibits proinflammatory cytokines production . the purpose of this study was to investigate the therapeutic effects of pentoxifylline on the treatment of autoimmune diabetes in mice.materials and methods : diabetes was induced by multiple low dose of streptozotocin ( mlds ) injection ( 40 mg / kg / day for 5 consecutive days ) in male c57bl/6 mice . after induction of diabetes , mice were treated with pentoxifylline ( 100 mg / kg / day ip ) for 21 days . blood glucose levels and plasma levels of insulin were measured . splenocytes were tested for proliferation by mtt test and cytokine production by elisa.results:pentoxifylline treatment prevented hyperglycemia and increased plasma insulin levels in the diabetic mice . aside from reducing lymphocyte proliferation , pentoxifylline significantly inhibited the production of proinflammatory interleukin 17 ( il-17 ) as well as interferon gamma ( ifn- ) , while increased anti - inflammatory cytokine il-10 as compared with those in mlds group ( diabetic control group).conclusion : these findings indicate that pentoxifylline may have therapeutic effect against the autoimmune destruction of the pancreatic beta - cells during the development of mlds - induced type 1 diabetes in mice . |
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"determinar a presena de anticorpos ige especficos para superantgenos estafiloccicos e o grau de sensibilizao mediada por esses , assim como se esses esto associados gravidade da asma em pacientes adultos .",
"estudo transversal incluindo asmticos adultos em acompanhamento ambulatorial em um hospital universitri... | abstractobjective : to determine the presence of staphylococcal superantigen - specific ige antibodies and degree of ige - mediated sensitization , as well as whether or not those are associated with the severity of asthma in adult patients . methods : this was a cross - sectional study involving outpatients with asthma under treatment at a tertiary care university hospital in the city of rio de janeiro , brazil . consecutive patients were divided into two groups according to the severity of asthma based on the global initiative for asthma criteria : mild asthma ( ma ) , comprising patients with mild intermittent or persistent asthma ; and moderate or severe asthma ( msa ) . we determined the serum levels of staphylococcal toxin - specific ige antibodies , comparing the results and performing a statistical analysis . results : the study included 142 patients : 72 in the ma group ( median age = 46 years ; 59 females ) and 70 in the msa group ( median age = 56 years ; 60 females ) . in the sample as a whole , 62 patients ( 43.7% ) presented positive results for staphylococcal toxin - specific ige antibodies : staphylococcal enterotoxin a ( sea ) , in 29 ( 20.4% ) ; seb , in 35 ( 24.6% ) ; sec , in 33 ( 23.2% ) ; and toxic shock syndrome toxin ( tsst ) , in 45 ( 31.7% ) . the mean serum levels of ige antibodies to sea , seb , sec , and tsst were 0.96 u / l , 1.09 u / l , 1.21 u / l , and 1.18 u / l , respectively . there were no statistically significant differences between the two groups in terms of the qualitative or quantitative results . conclusions : serum ige antibodies to sea , seb , sec , and tsst were detected in 43.7% of the patients in our sample . however , neither the qualitative nor quantitative results showed a statistically significant association with the clinical severity of asthma . |
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"the family is the cornerstone of human social support network and its presence is essential in everyone s life . changes inevitably occur in families with illness and hospitalization of a family member . in other words , among the sources of stress for families are accidents leading to hospitalization particularly... | background : since the family is a social system , the impairment in each of its component members may disrupt the entire family system . one of the stress sources for families is accidents leading to hospitalization particularly in the intensive care unit ( icu ) . in many cases , the families needs in patient care are not met that cause dissatisfaction . since the nurses spend a lot of time with patients and their families , they are in a good position to assess their needs and perform appropriate interventions . therefore , this study was conducted to determine the effectiveness of nursing interventions based on family needs on family satisfaction level of hospitalized patients in the neurosurgery icu.materials and methods : this clinical trial was conducted in the neurosurgery icu of al - zahra hospital , isfahan , iran in 2010 . sixty four families were selected by simple sampling method and were randomly placed in two groups ( test and control ) using envelopes . in the test group , some interventions were performed to meet their needs . in the control group , the routine actions were only carried out . the satisfaction questionnaire was completed by both groups two days after admission and again on the fourth day.findings:both of the intervention and control groups were compared in terms of the mean satisfaction scores before and after intervention . there was no significant difference in mean satisfaction scores between test and control groups before the intervention . the mean satisfaction score significantly increased after the intervention compared to the control group.conclusions:nursing interventions based on family needs of hospitalized patients in the icu increase their satisfaction . attention to family nursing should be planned especially in the icus . |
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"development of human societies and industrialization as well as changes in stress sources has changed disease pattern in civilized societies . as a result , the disease pattern has changed from traditional diseases such as infectious diseases and malnutrition to diseases such as heart disease , diabetes , accident... | background and objective : anxiety and depression are among the psychological disorders in heart
surgeries . establishing a simple communication is essential to reduce anxiety and depression . hence , the objective of the present studywas to examine the impact of peplau therapeutic communication model on anxiety and depression in patients , who were candidate for coronary artery bypass in al - zahra heart hospital , shiraz during 2012 - 2013 .
methods : this is a clinical trial in which 74 patients were randomly divided into intervention and control groups , each consisted of 37 patients . anxiety and depression levels were assessed before , and two and four months after intervention using the hospital anxiety and depression scale ( hads ) . seven therapeutic communication sessions were held in four stages . data were analyzed with the spss ( version 16 ) using analysis of covariance . results : the mean anxiety and depression levels decreased in the intervention group after the therapeutic communication ( p<0.01 ) . anxiety scores in the intervention group before and after intervention were 10.23 and 9.38 , respectively . while the corresponding scores in the control group were 10.26 and 11.62 , respectively . depression scores in the intervention group before and after intervention were 11 and 9.13 , respectively . the corresponding scores in the control group were 11.30 and 12.08 , respectively . conclusion : the results demonstrated the positive role of therapeutic communication in reducing anxiety and depression of the patients . therefore , the therapeutic communication is recommended as a simple , cost effective and efficient method in this area .
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"sixty - four patients in nepal that met us department of defense enrollment criteria ( 9 ) for influenzalike illness were evaluated by using onsite rapid influenza tests ( optical immunoassay rapid diagnostic tests , thermo electron corp . throat swab specimens were collected within the first 72 hours of onset of ... | worldwide emergence of variant viruses has prompted a change in the 20052006 h3n2 influenza a vaccine strain . |
["rising levels of obesity are becoming a worldwide phenomenon and are increasingly identified as a (...TRUNCATED) | "excess weight has generally been associated with adverse health outcomes ; however , the link betwe(...TRUNCATED) |
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