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Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Responses of primate frontal cortex neurons during natural vocal communication. The role of primate frontal cortex in vocal communication and its significance in language evolution have a controversial history. While evidence indi... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Humoral immune responses depend on B cells encountering antigen, interacting with helper T cells, proliferating and differentiating i... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Gpr124 is essential for blood–brain barrier integrity in central nervous system disease Although blood–brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial recept... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer Immune checkpoint inhibitors result in impressive clinical responses, but optimal results will require combination with each other and othe... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectivenes... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study Objectives To develop and validate updated QRISK3 prediction algorithms to estimate the 10... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling Nuclear factor-κB (NF-κB) is constitutively activated in diverse human malignancies by mechanisms that are not understood. The MUC1 oncoprotein ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabili... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Inflammatory signaling in human Tuberculosis granulomas is spatially organized Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To underst... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: GSK-3-mediated phosphorylation enhances Maf-transforming activity. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf protein... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Reprogramming of human fibroblasts to pluripotency with lineage specifiers. Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies rep... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury Spinal cord injuries (SCIs) in humans and experimental animals are often associated with varying degrees of spontane... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A framework for understanding and targeting residual disease in oncogene-driven solid cancers Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable res... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Long term pharmacotherapy for obesity and overweight: updated meta-analysis. OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of rando... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: New opportunities: the use of nanotechnologies to manipulate and track stem cells. Nanotechnologies are emerging platforms that could be useful in measuring, understanding, and manipulating stem cells. Examples include magnetic na... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A chikungunya fever vaccine utilizing an insect-specific virus platform Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity b... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A Comparison of Cost Effectiveness Using Data from Randomized Trials or Actual Clinical Practice: Selective Cox-2 Inhibitors as an Example BACKGROUND Data on absolute risks of outcomes and patterns of drug use in cost-effectivenes... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins. The ER-associated degradation (ERAD) pathway serves as an important cellular safeguard by directing incorrectly folded and unassembled protein... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Tumor necrosis factor (TNF), a key effector in controlling tuberculosis, is thought to exert protection by di... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of crucial que... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Human SNP Links Differential Outcomes in Inflammatory and Infectious Disease to a FOXO3-Regulated Pathway The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis Osteogenesis during bone modeling and remodeling is coupled with angiogenesis. A recent study showed that a specific vessel subtype, strongl... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Regenerative medicine is predicated on understanding the mechanisms regulating development and applying these conditions to direct stem cell fat... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells &NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Relapse specific mutations in NT5C2 in childhood acute lymphoblastic leukemia Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The b... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis. IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese indivi... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis Previous studies investigating the role of smooth muscle cells (SMCs) and macrophages in the pathogenesis of atheros... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-spe... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: The EMBL nucleotide sequence database. The EMBL Nucleotide Sequence Database (http://www.ebi.ac.uk/embl. html ) constitutes Europe's primary nucleotide sequence resource. DNA and RNA sequences are directly submitted from researche... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: CLASPs link focal adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell mo... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Anxiety OBJECTIVES To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings. DATA SOURCES Embase, Medline, PsycLIT,... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Randomized trial of folic acid supplementation and serum homocysteine levels. BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is kno... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies BACKGROUND Genetic and epidemiological evidence suggests an inverse association between B-type... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake. CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal int... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming. Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Persistence of HIV-1 Receptor-Positive Cells after HSV-2 Reactivation: A Potential Mechanism for Increased HIV-1 Acquisition To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition,... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells. In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripo... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Perinatal mortality in rural China: retrospective cohort study. OBJECTIVES To explore the use of local civil registration data to assess the perinatal mortality in a typical rural county in a less developed province in China, 1999... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation Vascular disease progression is associated with marked changes in vascular smooth muscle cell (SMC) phenotype... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Patient Outcomes with Teaching Versus Nonteaching Healthcare: A Systematic Review Background Extensive debate exists in the healthcare community over whether outcomes of medical care at teaching hospitals and other healthcare unit... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather than regulatory capacity in mRNA translation. Here we... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network. Pluripotent embryonic stem cells (ESCs) maintain self-renewal and the potential for rapid response to differentiation cu... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Discontinuation and non-publication of surgical randomised controlled trials: observational study OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients unde... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: HTLV-I/II associated disease in England and Wales, 1993-7: retrospective review of serology requests. Apart from HIV two exogenous retroviruses (human T cell leukaemia viruses type I (HTLV-I) and type II (HTLV-II)) infect humans. ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number. Immune clearance and resource limitation (via red blood cell depletion) shape the peaks and troughs of malaria parasitemia,... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist cons... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 BACKGROUND Health... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identi... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Reproductive period and risk of dementia in postmenopausal women. CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident de... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: ADHD medications and risk of serious cardiovascular events in young and middle-aged adults. CONTEXT More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity diso... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A chikungunya fever vaccine utilizing an insect-specific virus platform Traditionally, vaccine development involves tradeoffs between immunogenicity and safety. Live-attenuated vaccines typically offer rapid and durable immunity b... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Tricyclic antidepressants and headaches: systematic review and meta-analysis OBJECTIVE To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headac... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, b... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic sus... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A framework for understanding and targeting residual disease in oncogene-driven solid cancers Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable res... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: COPI Complex Is a Regulator of Lipid Homeostasis Lipid droplets are ubiquitous triglyceride and sterol ester storage organelles required for energy storage homeostasis and biosynthesis. Although little is known about lipid droplet... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. Variation in cerebral cortex size and complexity is thought to contribute to diffe... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and pos... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. An interaction between RTEL1... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study. OBJECTIVES To explore the association between a stable partnership and clinical o... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Preventing deaths by drowning in children in the United Kingdom: have we made progress in 10 years? Population based incidence study. Detailed information on drowning in children is not routinely collected by offices of national s... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding si... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including indu... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: 2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. Variation in cerebral cortex size and complexity is thought to contribute to diffe... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation Myeloid-derived suppressor cells (MDSCs) play critical roles in primary and metastatic cancer progression. MDSC regulation is widely va... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as sponges for a microRNA (miRNA) through their binding si... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Assessment of Volume Depletion in Children with Malaria Background The degree of volume depletion in severe malaria is currently unknown, although knowledge of fluid compartment volumes can guide therapy. To assist management of s... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Effect of smoking reduction on lung cancer risk. CONTEXT Many smokers are unable or unwilling to completely quit smoking. A proposed means of harm reduction is to reduce the number of cigarettes smoked per day. However, it is not ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive stranded RNA viruses Although susceptibility of neurons in the brain to microbial infection is a majo... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: 4-1BB Costimulation Ameliorates T Cell Exhaustion Induced by Tonic Signaling of Chimeric Antigen Receptors Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, bu... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Enhancer Evolution across 20 Mammalian Species The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming. Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Fission Yeast Scm3: A CENP-A Receptor Required for Integrity of Subkinetochore Chromatin The mechanisms ensuring specific incorporation of CENP-A at centromeres are poorly understood. Mis16 and Mis18 are required for CENP-A locali... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Bullying in school: are short pupils at risk? Questionnaire study in a cohort. Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: “Rapid-Impact Interventions”: How a Policy of Integrated Control for Africa's Neglected Tropical Diseases Could Benefit the Poor Over the past two decades there have been significant achievements in the control of a handful of imp... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltra... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Memory CD4+ T cells induce innate responses independently of pathogen Inflammation induced by recognition of pathogen-associated molecular patterns markedly affects subsequent adaptive responses. We asked whether the adaptive immu... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mental Health Conditions Among Patients Seeking and Undergoing Bariatric Surgery: A Meta-analysis. IMPORTANCE Bariatric surgery is associated with sustained weight loss and improved physical health status for severely obese indivi... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabili... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infec... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity h... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression Recognition of modified histones by ‘reader’ proteins plays a critical role in the regulation of chromatin. H3K36 trimethylation (H3K36me3) is dep... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabili... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Migraine and cardiovascular disease: systematic review and meta-analysis. OBJECTIVE To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness of Raf an... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Liver receptor homolog-1 is essential for pregnancy Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear rece... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter Interleukin-18 (IL18) participates in atherogenesis through several putative mechanisms. Interruption of IL18 actio... | A | scifact |
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