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Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs Autophagy is the primary catabolic process triggered in response to starvation. Although autophagic regulation within the cytosolic compartm... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Inflammatory signaling in human Tuberculosis granulomas is spatially organized Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To underst... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mental health problems of homeless children and families: longitudinal study. OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study.... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disab... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict Regulatory T (Treg) cells, whose differentiation and function are controlled by X chromosome-encoded transcription factor Foxp3, a... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia. Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Complex Tissue and Disease Modeling using hiPSCs. Defined genetic models based on human pluripotent stem cells have opened new avenues for understanding disease mechanisms and drug screening. Many of these models assume cell-auton... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. L... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care OBJECTIVE To mea... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. OBJECTIVE To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis. DESIGN Population based case-co... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Direct sensing of systemic and nutritional signals by hematopoietic progenitors in Drosophila The Drosophila lymph gland is a haematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor in ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Risk factors at medical school for subsequent professional misconduct: multicentre retrospective case-control study OBJECTIVE To determine whether there are risk factors in a doctor's time at medical school that are associated wit... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: ARID1A-mutated ovarian cancers depend on HDAC6 activity ARID1A, encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutatio... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by mol... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. An... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Macrophages Facilitate Electrical Conduction in the Heart Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction throu... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. L... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel. The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Paraneoplastic thrombocytosis: the secrets of tumor self-promotion. Paraneoplastic thrombocytosis is associated with many solid tumors and often correlates with reduced survival. Recent studies suggest that a pathogenic feed back ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelia... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors. Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have o... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Modification of kidney barrier function by the urokinase receptor Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cel... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Enhancer Evolution across 20 Mammalian Species The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer. However, it rem... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Malaria biology and disease pathogenesis: insights for new treatments Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone an... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Reconstruction of the yeast Snf1 kinase regulatory network reveals its role as a global energy regulator Highly conserved among eukaryotic cells, the AMP-activated kinase (AMPK) is a central regulator of carbon metabolism. To map ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Molecular characterization of the yeast meiotic regulatory gene RIM1. In the yeast Saccharomyces cerevisiae, genetic studies suggest that the RIM1 gene encodes a positive regulator of meiosis. rim1 mutations cause reduced expressi... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians' Health Study II randomized controlled trial. CONTEXT Many individuals take vitamins in the hopes of preventing chronic diseases such as cancer... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Resistance to antimicrobials in humans and animals. Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to app... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells. The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic stem/progenitor cell (HSPC) migration out of the niche a... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Autophagy mediates degradation of nuclear lamina Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human disease... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Resistance to antimicrobials in humans and animals. Overusing antibiotics is not the only cause and reducing use is not the only solution W arning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to app... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs b... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Changes in the prevalence of cerebral palsy for children born very prematurely within a population-based program over 30 years. CONTEXT Although cerebral palsy (CP) among extremely premature infants has been reported as a major mo... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Relation between Medicare screening reimbursement and stage at diagnosis for older patients with colon cancer. CONTEXT Medicare's reimbursement policy was changed in 1998 to provide coverage for screening colonoscopies for patient... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus. The non-enveloped bacilliform viruses are the second group of plant viruses known to ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers Human tumors show a high level of genetic heterogeneity, but the processes that influence the timing and route of metastatic disseminatio... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Sudden infant death syndrome. Despite declines in prevalence during the past two decades, sudden infant death syndrome (SIDS) continues to be the leading cause of death for infants aged between 1 month and 1 year in developed coun... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System &NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate respons... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Radioiodine treatment of multinodular non-toxic goitre. OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients w... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Cell Stem Cell Review FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including indu... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Secondary aerosolization of viable Bacillus anthracis spores in a contaminated US Senate Office. CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group. CONTEXT Risedronate... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Long term pharmacotherapy for obesity and overweight: updated meta-analysis. OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of rando... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins How individual cells respond to mechanical forces is of considerable interest to biologists as force affects many aspects of cell behaviour. The a... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Microenvironmental regulation of tumor progression and metastasis Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within th... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin αvβ3 serves as ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut Salmonella typhimurium causes a localized enteric infection in immunocompetent individuals, whereas HIV-infecte... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Anxiety OBJECTIVES To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings. DATA SOURCES Embase, Medline, PsycLIT,... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin αvβ3 serves as ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer OBJECTIVE Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impai... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are po... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Transglutaminase 2 Undergoes a Large Conformational Change upon Activation Human transglutaminase 2 (TG2), a member of a large family of enzymes that catalyze protein crosslinking, plays an important role in the extracellular matr... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial BACKGROUND Elderly and frail patients with cancer, although often treated with chemothera... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis. OBJECTIVE To determine whether ultrasound imaging can reduce the risk of failed lumbar punctures or epidural catheterisati... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: A Candidate Gene Approach Identifies the TRAF1/C5 Region as a Risk Factor for Rheumatoid Arthritis Correction for: Kurreeman FAS, Padyukov L, Marques RB, Schrodi SJ, Seddighzadeh M, et al. (2007) A Candidate Gene Approach Identifi... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and m... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are po... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. OBJECTIVE To investigate the association between gastric cancer and prior infection with Helicobacter py... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Resistance to apoptosis, often achieved by the overexpression of antiapoptotic proteins, is common and perhaps required in the genesis of cancer. However, it rem... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabili... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Misunderstandings in prescribing decisions in general practice: qualitative study. OBJECTIVES To identify and describe misunderstandings between patients and doctors associated with prescribing decisions in general practice. DESIG... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Sublime Microglia: Expanding Roles for the Guardians of the CNS Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury,... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation Observational clinical and ex vivo studies have established a strong association between atrial fibrillation and inflammation. However, whether inflammation is ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Loss of the RhoGAP SRGP-1 promotes the clearance of dead and injured cells in Caenorhabditis elegans Multicellular animals rapidly clear dying cells from their bodies. Many of the pathways that mediate this cell removal are conser... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive stranded RNA viruses Although susceptibility of neurons in the brain to microbial infection is a majo... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care OBJECTIVE To assess the risks of amputation, blindness, severe kidney failure, hype... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Metformin reverses established lung fibrosis in a bleomycin model Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs1. Cellular metabolism re... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2 To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have a... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Combination varenicline and bupropion SR for tobacco-dependence treatment in cigarette smokers: a randomized trial. IMPORTANCE Combining pharmacotherapies for tobacco-dependence treatment may increase smoking abstinence. OBJECTIVE... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance Reproductive cessation is perhaps the earliest aging phenotype that humans experience. Similarly, reproduction of Caenorhabditis e... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. CONTEXT Observational studies suggest that surgically induced loss of weight may be effective therapy for type 2 diabetes. OBJ... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Regulation of in situ to invasive breast carcinoma transition. The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myo... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Antibody-Based HIV-1 Vaccines: Recent Developments and Future Directions The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines tha... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: GSK-3-mediated phosphorylation enhances Maf-transforming activity. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf protein... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. Dopaminergic midbrain neurons integrate signals on food palatability and food-associated reward into the complex control of energy homeostas... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: The non-coding RNA landscape of human hematopoiesis and leukemia Non-coding RNAs have emerged as crucial regulators of gene expression and cell fate decisions. However, their expression patterns and regulatory functions during nor... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Population Density, Water Supply, and the Risk of Dengue Fever in Vietnam: Cohort Study and Spatial Analysis BACKGROUND Aedes aegypti, the major vector of dengue viruses, often breeds in water storage containers used by households... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Dynamic Helix Interactions in Transmembrane Signaling Studying how protein transmembrane domains transmit signals across membranes is beset by unique challenges. Here, we discuss the circumstances that have led to success and refl... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. CONTEXT Findings from previous studies of the effects of exercise training on patient-reported health sta... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Autophagy mediates degradation of nuclear lamina Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human disease... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due t... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Detection of sweet and umami taste in the absence of taste receptor T1r3. The tastes of sugars (sweet) and glutamate (umami) are thought to be detected by T1r receptors expressed in taste cells. Molecular genetics and heterologous... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evoluti... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Prevention of malaria in long-term travelers. CONTEXT Long-term travelers, defined here as those traveling for periods of 6 months or longer, face particular challenges regarding malaria prevention. Current guidelines for malaria ... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue. BACKGROUND We have developed techniques to implant angiogenic patches onto the epicardium... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity i... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: a randomized trial. CONTEXT Dexamethasone is widely used to prevent postoperative nausea and vomiting (PONV) in pediatric to... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Bullying in school: are short pupils at risk? Questionnaire study in a cohort. Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: Increased Microerythrocyte Count in Homozygous α+-Thalassaemia Contributes to Protection against Severe Malarial Anaemia BACKGROUND The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-... | B | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing family of proteins. Compared to other members of the family... | A | scifact |
Question: Please judge whether the evidence supports or contradicts the claim.
Evidence: The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study OBJECTIVE To determine whether higher past exposure to particulate air pollution is associated with prevalent h... | B | scifact |
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