metadata
license: mit
tags:
- protein-structure-prediction
- biomolecular-modeling
- structural-biology
- computational-biology
- alphafold
pipeline_tag: other
Triangle Multiplication is All You Need for Biomolecular Structure Representations
By Jeffrey Ouyang-Zhang, Pranav Murugan, Daniel J. Diaz, Gianluca Scarpellini, Richard Strong Bowen, Nate Gruver, Adam Klivans, Philipp Krähenbühl, Aleksandra Faust, and Maruan Al-Shedivat
Genesis Research & UT Austin
Please see our GitHub Repository for instructions on how to use this model.
Model Description
Pairmixer is an efficient alternative to AlphaFold3's Pairformer architecture for biomolecular structure prediction. By eliminating triangle attention while preserving geometric reasoning through triangle multiplication, Pairmixer achieves:
- 4× faster inference compared to Pairformer
- 34% lower training cost
- Competitive accuracy on standard benchmarks
Citation
If you use Pairmixer in your research, please cite:
@inproceedings{pairmixer2025,
title={Triangle Multiplication is All You Need for Biomolecular Structure Representations},
author={Ouyang-Zhang, Jeffrey and Murugan, Pranav and Diaz, Daniel J. and Scarpellini, Gianluca and Bowen, Richard Strong and Gruver, Nate and Klivans, Adam and Kr{\"a}henb{\"u}hl, Philipp and Faust, Aleksandra and Al-Shedivat, Maruan},
year={2025},
}
Additional Resources
- Paper (ArXiv)
- GitHub Repository
License
This model is released under the MIT License.