| | --- |
| | license: mit |
| | tags: |
| | - protein-structure-prediction |
| | - biomolecular-modeling |
| | - structural-biology |
| | - computational-biology |
| | - alphafold |
| | pipeline_tag: other |
| | --- |
| | |
| | # Triangle Multiplication is All You Need for Biomolecular Structure Representations |
| |
|
| | By [Jeffrey Ouyang-Zhang](https://jozhang97.github.io/), [Pranav Murugan](https://pranavmurugan.github.io), [Daniel J. Diaz](http://danny305.github.io), [Gianluca Scarpellini](https://scarpellini.dev/), [Richard Strong Bowen](http://rsbowen.github.io), [Nate Gruver](https://ngruver.github.io), [Adam Klivans](https://www.cs.utexas.edu/users/klivans/), [Philipp Krähenbühl](http://www.philkr.net/), [Aleksandra Faust](https://www.afaust.info), and [Maruan Al-Shedivat](https://maruan.alshedivat.com) |
| |
|
| | *Genesis Research & UT Austin* |
| |
|
| | Please see our [GitHub Repository](https://github.com/genesistherapeutics/pairmixer) for instructions on how to use this model. |
| |
|
| | ## Model Description |
| |
|
| | Pairmixer is an efficient alternative to AlphaFold3's Pairformer architecture for biomolecular structure prediction. By eliminating triangle attention while preserving geometric reasoning through triangle multiplication, Pairmixer achieves: |
| |
|
| | - **4× faster inference** compared to Pairformer |
| | - **34% lower training cost** |
| | - Competitive accuracy on standard benchmarks |
| |
|
| | ## Citation |
| |
|
| | If you use Pairmixer in your research, please cite: |
| |
|
| | ```bibtex |
| | @inproceedings{pairmixer2025, |
| | title={Triangle Multiplication is All You Need for Biomolecular Structure Representations}, |
| | author={Ouyang-Zhang, Jeffrey and Murugan, Pranav and Diaz, Daniel J. and Scarpellini, Gianluca and Bowen, Richard Strong and Gruver, Nate and Klivans, Adam and Kr{\"a}henb{\"u}hl, Philipp and Faust, Aleksandra and Al-Shedivat, Maruan}, |
| | year={2025}, |
| | } |
| | ``` |
| |
|
| | ## Additional Resources |
| |
|
| | - [Paper](https://arxiv.org/abs/2510.18870) (ArXiv) |
| | - [GitHub Repository](https://github.com/genesistherapeutics/pairmixer) |
| |
|
| | ## License |
| |
|
| | This model is released under the MIT License. |
