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title: README
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# Liver Cell Biology Research Group(LIVR)
Brussels Health Campus • Vrije Universiteit Brussel • Brussels • Belgium
## Mission
Advance understanding of liver cell diversity, regeneration and fibrosis to drive novel biomarkers, in vitro disease models and therapeutic strategies for chronic liver disorders.
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## Research Objectives
- **Cellular Characterization**
Profile healthy vs. diseased liver cell types at single‑cell resolution.
- **Fibrosis Mechanisms**
Dissect pathways of hepatic stellate cell activation, fibrogenesis and resolution.
- **Biomarker Discovery**
Identify stellate‑cell‑specific markers for non‑invasive fibrosis staging.
- **Disease Modeling**
Build iPSC‑derived liver cell co‑cultures and organoids to recreate MASLD and other chronic conditions.
- **Regeneration & Progenitors**
Elucidate the role of liver progenitor cells in tissue repair.
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## Key Collaborations & Networks
- **ImAgE‑D** (Marie Skłodowska‑Curie ITN, Oct 2023 – Sep 2027)
High‑speed, super‑resolution imaging of endothelial and liver cells.
- **DeLIVERy** (EIC Pathfinder, May 2022 – Apr 2026)
Personalized polypharmacy testing on patient‑derived mini‑livers.
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## Publications & Resources
- **Latest Publications**
- *JHEP Reports*: “HSC single‑cell atlas reveals activation across etiologies”
- *Biofabrication*: “iPSC‑derived liver spheroids to model fibrosis”
- *Science*: “Hippo signaling instructs ectopic organ growth”
- **Full Publication List:**
Browse all [publications (2010–present)](https://pubmed.ncbi.nlm.nih.gov/?term=van+Grunsven+L&sort=date)
Research Portal [Click here](https://researchportal.vub.be/en/organisations/liver-cell-biology/publications/).
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## Team & Training
- **Current Members** | **Former Members**
Explore profiles and roles on our [Team page](https://livr.research.vub.be/livr-members/livr-members).
- **Doctoral & Post‑doc Training**
Interactive workshops, imaging courses, and 3R‑principle seminars for early‑career researchers.
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## News & Events
- **Belgian Stem Cell Meeting** – Nov 28 2025 @ ULB Erasme Campus
- **Upcoming Seminars** & “Film Nights” showcasing 3R approaches and mini‑liver therapies
- Follow live updates in [News & Events](https://livr.research.vub.be/news-events).
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## Contact
Laarbeeklaan 103, Building D – Room D022
1090 Brussels, Belgium
jmlazou@vub.be | +32 2 477 4409
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> _“By unlocking liver cell biology, we pave the way for precision therapies in chronic liver disease.”_
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