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| ClinicalMatch AI — Graph Seeder v2 | |
| 100 k synthetic patients · 20 oncology conditions | |
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| [1/5] Seeding clinical trials from ClinicalTrials.gov... | |
| breast cancer: 50 trials fetched | |
| prostate cancer: 50 trials fetched | |
| non-small cell lung cancer: 50 trials fetched | |
| colorectal cancer: 50 trials fetched | |
| ovarian cancer: 50 trials fetched | |
| melanoma: 50 trials fetched | |
| leukemia: 50 trials fetched | |
| lymphoma: 50 trials fetched | |
| glioblastoma: 50 trials fetched | |
| pancreatic cancer: 50 trials fetched | |
| bladder cancer: 50 trials fetched | |
| renal cell carcinoma: 50 trials fetched | |
| thyroid cancer: 50 trials fetched | |
| multiple myeloma: 50 trials fetched | |
| endometrial cancer: 50 trials fetched | |
| cervical cancer: 50 trials fetched | |
| gastric cancer: 50 trials fetched | |
| hepatocellular carcinoma: 50 trials fetched | |
| head and neck cancer: 50 trials fetched | |
| sarcoma: 50 trials fetched | |
| Total trials seeded: 1000 | |
| [2/5] Seeding medications from RxNorm... | |
| trastuzumab: 5 RxCUI concepts | |
| pembrolizumab: 5 RxCUI concepts | |
| nivolumab: 5 RxCUI concepts | |
| osimertinib: 4 RxCUI concepts | |
| olaparib: 5 RxCUI concepts | |
| enzalutamide: 5 RxCUI concepts | |
| bevacizumab: 5 RxCUI concepts | |
| rituximab: 5 RxCUI concepts | |
| imatinib: 5 RxCUI concepts | |
| dabrafenib: 5 RxCUI concepts | |
| vemurafenib: 2 RxCUI concepts | |
| atezolizumab: 5 RxCUI concepts | |
| durvalumab: 4 RxCUI concepts | |
| cetuximab: 4 RxCUI concepts | |
| erlotinib: 5 RxCUI concepts | |
| capecitabine: 4 RxCUI concepts | |
| Total medications seeded: 16 | |
| [3/5] Seeding diagnoses from ICD-10 CM... | |
| ICD-10 C50: 20 codes | |
| ICD-10 C61: 1 codes | |
| ICD-10 C34: 16 codes | |
| ICD-10 C18: 10 codes | |
| ICD-10 C56: 4 codes | |
| ICD-10 C43: 20 codes | |
| ICD-10 C91: 20 codes | |
| ICD-10 C85: 20 codes | |
| ICD-10 C71: 10 codes | |
| ICD-10 C25: 8 codes | |
| Total diagnoses seeded: 129 | |
| [4/5] Seeding supporting literature from PubMed... | |
| breast cancer: 5 publications linked | |
| prostate cancer: 5 publications linked | |
| non-small cell lung cancer: 5 publications linked | |
| colorectal cancer: 5 publications linked | |
| ovarian cancer: 5 publications linked | |
| Total publications seeded: 25 | |
| [5/5] Seeding biomarkers (curated from COSMIC/NCIT)... | |
| 57 biomarkers seeded and linked to conditions | |
| [+] Deriving eligibility relationships... | |
| Eligibility relationships derived. | |
| [6/6] Generating 100,000 clinically-informed synthetic patients... | |
| (SEER incidence weights · TCGA biomarker prevalence · US Census demographics) | |
| breast cancer: 17,222 patients — already done, skipping | |
| non-small cell lung cancer: 14,444 patients (40 trials) [resuming from 4,000] | |
| ↳ wrote 10,444 patients | total so far: 31,666/100,000 | edges: 351,181 | |
| prostate cancer: 10,556 patients (44 trials) | |
| ↳ wrote 10,556 patients | total so far: 42,222/100,000 | edges: 766,259 | |
| colorectal cancer: 9,444 patients (34 trials) | |
| ↳ wrote 9,444 patients | total so far: 51,666/100,000 | edges: 1,047,777 | |
| melanoma: 6,111 patients (56 trials) | |
| ↳ wrote 6,111 patients | total so far: 57,777/100,000 | edges: 1,329,267 | |
| bladder cancer: 5,000 patients (41 trials) | |
| ↳ wrote 5,000 patients | total so far: 62,777/100,000 | edges: 1,509,909 | |
| renal cell carcinoma: 4,667 patients (42 trials) | |
| ↳ wrote 4,667 patients | total so far: 67,444/100,000 | edges: 1,687,802 | |
| lymphoma: 4,667 patients (46 trials) | |
| ↳ wrote 4,667 patients | total so far: 72,111/100,000 | edges: 1,847,153 | |
| endometrial cancer: 4,222 patients (40 trials) | |
| ↳ wrote 4,222 patients | total so far: 76,333/100,000 | edges: 1,992,865 | |
| leukemia: 3,889 patients (27 trials) | |
| ↳ wrote 3,889 patients | total so far: 80,222/100,000 | edges: 2,071,433 | |
| pancreatic cancer: 3,667 patients (35 trials) | |
| ↳ wrote 3,667 patients | total so far: 83,889/100,000 | edges: 2,172,901 | |
| thyroid cancer: 3,333 patients (41 trials) | |
| ↳ wrote 3,333 patients | total so far: 87,222/100,000 | edges: 2,302,009 | |
| multiple myeloma: 2,778 patients (50 trials) | |
| ↳ wrote 2,778 patients | total so far: 90,000/100,000 | edges: 2,415,994 | |
| gastric cancer: 2,000 patients (38 trials) | |
| ↳ wrote 2,000 patients | total so far: 92,000/100,000 | edges: 2,474,564 | |
| ovarian cancer: 2,000 patients (29 trials) | |
| ↳ wrote 2,000 patients | total so far: 94,000/100,000 | edges: 2,516,658 | |
| hepatocellular carcinoma: 1,667 patients (47 trials) | |
| ↳ wrote 1,667 patients | total so far: 95,667/100,000 | edges: 2,578,834 | |
| glioblastoma: 1,333 patients (45 trials) | |
| ↳ wrote 1,333 patients | total so far: 97,000/100,000 | edges: 2,623,714 | |
| head and neck cancer: 1,333 patients (49 trials) | |
| ↳ wrote 1,333 patients | total so far: 98,333/100,000 | edges: 2,677,369 | |
| cervical cancer: 889 patients (10 trials) | |
| ↳ wrote 889 patients | total so far: 99,222/100,000 | edges: 2,685,508 | |
| sarcoma: 778 patients (50 trials) | |
| ↳ wrote 778 patients | total so far: 100,000/100,000 | edges: 2,717,650 | |
| ✓ Total patients: 100,000 | |
| ✓ Total ELIGIBLE_FOR edges: 2,717,650 | |
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| Seeding complete in 21.1 min | |
| Trials: 1000 | |
| Medications: 16 | |
| Diagnoses: 129 | |
| Publications: 25 | |
| Biomarkers: 57 | |
| Patients: 100,000 | |
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