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| { | |
| "medical_database": { | |
| "version": "1.0", | |
| "last_updated": "2026-01-21", | |
| "total_conditions": 15, | |
| "categories": [ | |
| { | |
| "category_id": "CARDIO_001", | |
| "category_name": "Cardiovascular Diseases", | |
| "conditions": [ | |
| { | |
| "condition_id": "CVD_001", | |
| "name": "Hypertension", | |
| "common_name": "High Blood Pressure", | |
| "severity": "moderate to severe", | |
| "prevalence": "31% of adults worldwide", | |
| "symptoms": [ | |
| { | |
| "symptom": "Headaches", | |
| "frequency": "common", | |
| "severity": "mild to moderate" | |
| }, | |
| { | |
| "symptom": "Shortness of breath", | |
| "frequency": "occasional", | |
| "severity": "moderate" | |
| }, | |
| { | |
| "symptom": "Chest pain", | |
| "frequency": "rare", | |
| "severity": "severe" | |
| }, | |
| { | |
| "symptom": "Visual changes", | |
| "frequency": "occasional", | |
| "severity": "moderate" | |
| } | |
| ], | |
| "risk_factors": [ | |
| "Age over 60", | |
| "Family history", | |
| "Obesity (BMI > 30)", | |
| "High sodium intake (>2300mg/day)", | |
| "Sedentary lifestyle", | |
| "Excessive alcohol consumption" | |
| ], | |
| "diagnostic_tests": [ | |
| { | |
| "test_name": "Blood pressure measurement", | |
| "normal_range": "120/80 mmHg", | |
| "hypertension_threshold": "140/90 mmHg" | |
| }, | |
| { | |
| "test_name": "24-hour ambulatory monitoring", | |
| "purpose": "Confirm diagnosis and assess treatment" | |
| } | |
| ], | |
| "treatments": [ | |
| { | |
| "type": "medication", | |
| "name": "ACE Inhibitors", | |
| "examples": ["Lisinopril", "Enalapril"], | |
| "mechanism": "Relax blood vessels" | |
| }, | |
| { | |
| "type": "medication", | |
| "name": "Beta-blockers", | |
| "examples": ["Metoprolol", "Atenolol"], | |
| "mechanism": "Reduce heart rate and cardiac output" | |
| }, | |
| { | |
| "type": "lifestyle", | |
| "interventions": [ | |
| "Reduce sodium to <1500mg/day", | |
| "Exercise 150 minutes/week", | |
| "Maintain healthy weight", | |
| "Limit alcohol to 1-2 drinks/day" | |
| ] | |
| } | |
| ], | |
| "complications": [ | |
| "Stroke", | |
| "Heart attack", | |
| "Kidney damage", | |
| "Vision loss", | |
| "Peripheral artery disease" | |
| ], | |
| "prognosis": "Good with proper management and medication adherence" | |
| }, | |
| { | |
| "condition_id": "CVD_002", | |
| "name": "Coronary Artery Disease", | |
| "common_name": "CAD", | |
| "severity": "severe", | |
| "prevalence": "Leading cause of death globally", | |
| "symptoms": [ | |
| { | |
| "symptom": "Angina (chest pain)", | |
| "frequency": "common", | |
| "severity": "moderate to severe", | |
| "characteristics": "Pressure, squeezing, or burning sensation" | |
| }, | |
| { | |
| "symptom": "Shortness of breath", | |
| "frequency": "common", | |
| "severity": "moderate" | |
| }, | |
| { | |
| "symptom": "Heart palpitations", | |
| "frequency": "occasional", | |
| "severity": "mild to moderate" | |
| } | |
| ], | |
| "risk_factors": [ | |
| "High LDL cholesterol (>160 mg/dL)", | |
| "Smoking", | |
| "Diabetes mellitus", | |
| "Obesity", | |
| "Family history of early heart disease", | |
| "Chronic stress" | |
| ], | |
| "diagnostic_tests": [ | |
| { | |
| "test_name": "Electrocardiogram (ECG)", | |
| "purpose": "Detect heart rhythm abnormalities" | |
| }, | |
| { | |
| "test_name": "Coronary angiography", | |
| "purpose": "Visualize coronary artery blockages" | |
| }, | |
| { | |
| "test_name": "Stress test", | |
| "purpose": "Assess heart function during exercise" | |
| }, | |
| { | |
| "test_name": "Lipid panel", | |
| "normal_values": { | |
| "total_cholesterol": "<200 mg/dL", | |
| "LDL": "<100 mg/dL", | |
| "HDL": ">40 mg/dL (men), >50 mg/dL (women)", | |
| "triglycerides": "<150 mg/dL" | |
| } | |
| } | |
| ], | |
| "treatments": [ | |
| { | |
| "type": "medication", | |
| "name": "Statins", | |
| "examples": ["Atorvastatin", "Rosuvastatin"], | |
| "purpose": "Lower cholesterol" | |
| }, | |
| { | |
| "type": "procedure", | |
| "name": "Percutaneous Coronary Intervention (PCI)", | |
| "description": "Angioplasty with stent placement" | |
| }, | |
| { | |
| "type": "surgery", | |
| "name": "Coronary Artery Bypass Grafting (CABG)", | |
| "indication": "Severe multi-vessel disease" | |
| } | |
| ], | |
| "emergency_signs": [ | |
| "Severe chest pain lasting >5 minutes", | |
| "Pain radiating to arm, jaw, or back", | |
| "Shortness of breath with chest discomfort", | |
| "Nausea, cold sweat, lightheadedness" | |
| ] | |
| } | |
| ] | |
| }, | |
| { | |
| "category_id": "RESP_001", | |
| "category_name": "Respiratory Diseases", | |
| "conditions": [ | |
| { | |
| "condition_id": "RESP_001", | |
| "name": "Asthma", | |
| "severity": "mild to severe", | |
| "prevalence": "262 million people worldwide", | |
| "age_groups_affected": ["children", "adults", "elderly"], | |
| "symptoms": [ | |
| { | |
| "symptom": "Wheezing", | |
| "frequency": "common", | |
| "timing": "Often worse at night or early morning" | |
| }, | |
| { | |
| "symptom": "Shortness of breath", | |
| "frequency": "common", | |
| "severity": "variable" | |
| }, | |
| { | |
| "symptom": "Chest tightness", | |
| "frequency": "common", | |
| "description": "Feeling of pressure or constriction" | |
| }, | |
| { | |
| "symptom": "Coughing", | |
| "frequency": "very common", | |
| "timing": "Especially at night" | |
| } | |
| ], | |
| "triggers": [ | |
| { | |
| "category": "Allergens", | |
| "examples": ["Pollen", "Dust mites", "Pet dander", "Mold"] | |
| }, | |
| { | |
| "category": "Environmental", | |
| "examples": ["Cold air", "Air pollution", "Smoke", "Strong odors"] | |
| }, | |
| { | |
| "category": "Physical", | |
| "examples": ["Exercise", "Respiratory infections"] | |
| }, | |
| { | |
| "category": "Emotional", | |
| "examples": ["Stress", "Anxiety"] | |
| } | |
| ], | |
| "diagnostic_tests": [ | |
| { | |
| "test_name": "Spirometry", | |
| "measures": "Lung function (FEV1, FVC)", | |
| "diagnostic_criteria": "FEV1/FVC ratio <70%" | |
| }, | |
| { | |
| "test_name": "Peak flow meter", | |
| "purpose": "Monitor daily lung function at home" | |
| }, | |
| { | |
| "test_name": "Allergy testing", | |
| "purpose": "Identify specific triggers" | |
| } | |
| ], | |
| "treatments": [ | |
| { | |
| "type": "controller_medication", | |
| "name": "Inhaled Corticosteroids", | |
| "examples": ["Fluticasone", "Budesonide"], | |
| "frequency": "Daily", | |
| "purpose": "Reduce airway inflammation" | |
| }, | |
| { | |
| "type": "rescue_medication", | |
| "name": "Short-acting Beta-agonists", | |
| "examples": ["Albuterol", "Salbutamol"], | |
| "frequency": "As needed", | |
| "purpose": "Quick relief of symptoms" | |
| }, | |
| { | |
| "type": "combination_therapy", | |
| "name": "ICS/LABA", | |
| "examples": ["Fluticasone/Salmeterol"], | |
| "indication": "Moderate to severe asthma" | |
| } | |
| ], | |
| "asthma_action_plan": { | |
| "green_zone": { | |
| "description": "Doing well", | |
| "peak_flow": "80-100% of personal best", | |
| "action": "Continue regular medications" | |
| }, | |
| "yellow_zone": { | |
| "description": "Caution", | |
| "peak_flow": "50-80% of personal best", | |
| "action": "Use rescue inhaler, may need to increase controller medication" | |
| }, | |
| "red_zone": { | |
| "description": "Medical alert", | |
| "peak_flow": "<50% of personal best", | |
| "action": "Use rescue inhaler immediately and seek emergency care" | |
| } | |
| } | |
| }, | |
| { | |
| "condition_id": "RESP_002", | |
| "name": "Chronic Obstructive Pulmonary Disease", | |
| "abbreviation": "COPD", | |
| "severity": "progressive, severe", | |
| "prevalence": "3rd leading cause of death worldwide", | |
| "subtypes": ["Chronic bronchitis", "Emphysema"], | |
| "symptoms": [ | |
| { | |
| "symptom": "Chronic cough", | |
| "duration": "Present for at least 3 months in 2 consecutive years", | |
| "characteristics": "Productive cough with mucus" | |
| }, | |
| { | |
| "symptom": "Shortness of breath", | |
| "progression": "Worsens over time", | |
| "severity": "Initially with exertion, later at rest" | |
| }, | |
| { | |
| "symptom": "Wheezing", | |
| "frequency": "common" | |
| }, | |
| { | |
| "symptom": "Chest tightness", | |
| "frequency": "common" | |
| } | |
| ], | |
| "risk_factors": [ | |
| { | |
| "factor": "Smoking", | |
| "impact": "85-90% of COPD cases", | |
| "pack_years": "Risk increases with >20 pack-years" | |
| }, | |
| { | |
| "factor": "Occupational exposures", | |
| "examples": ["Coal dust", "Silica", "Chemical fumes"] | |
| }, | |
| { | |
| "factor": "Alpha-1 antitrypsin deficiency", | |
| "type": "Genetic", | |
| "prevalence": "Rare, 1-2% of COPD cases" | |
| } | |
| ], | |
| "GOLD_stages": [ | |
| { | |
| "stage": "GOLD 1 (Mild)", | |
| "FEV1": "≥80% predicted", | |
| "symptoms": "Minimal" | |
| }, | |
| { | |
| "stage": "GOLD 2 (Moderate)", | |
| "FEV1": "50-79% predicted", | |
| "symptoms": "Shortness of breath on exertion" | |
| }, | |
| { | |
| "stage": "GOLD 3 (Severe)", | |
| "FEV1": "30-49% predicted", | |
| "symptoms": "Significant limitation" | |
| }, | |
| { | |
| "stage": "GOLD 4 (Very Severe)", | |
| "FEV1": "<30% predicted", | |
| "symptoms": "Severe limitation, may need oxygen" | |
| } | |
| ], | |
| "treatments": [ | |
| { | |
| "type": "bronchodilator", | |
| "name": "Long-acting Beta-agonists (LABA)", | |
| "examples": ["Formoterol", "Salmeterol"] | |
| }, | |
| { | |
| "type": "bronchodilator", | |
| "name": "Long-acting Muscarinic Antagonists (LAMA)", | |
| "examples": ["Tiotropium", "Umeclidinium"] | |
| }, | |
| { | |
| "type": "therapy", | |
| "name": "Pulmonary rehabilitation", | |
| "components": ["Exercise training", "Education", "Nutritional counseling"] | |
| }, | |
| { | |
| "type": "oxygen_therapy", | |
| "indication": "Severe COPD with hypoxemia", | |
| "criteria": "PaO2 ≤55 mmHg or SpO2 ≤88%" | |
| } | |
| ], | |
| "prevention": { | |
| "primary": "Smoking cessation", | |
| "vaccinations": ["Influenza (annual)", "Pneumococcal", "COVID-19"] | |
| } | |
| } | |
| ] | |
| }, | |
| { | |
| "category_id": "ENDO_001", | |
| "category_name": "Endocrine Disorders", | |
| "conditions": [ | |
| { | |
| "condition_id": "ENDO_001", | |
| "name": "Type 2 Diabetes Mellitus", | |
| "severity": "chronic, progressive", | |
| "prevalence": "537 million adults worldwide", | |
| "pathophysiology": "Insulin resistance and relative insulin deficiency", | |
| "symptoms": [ | |
| { | |
| "symptom": "Polyuria", | |
| "description": "Increased urination", | |
| "mechanism": "Glucose in urine draws water" | |
| }, | |
| { | |
| "symptom": "Polydipsia", | |
| "description": "Increased thirst", | |
| "mechanism": "Dehydration from polyuria" | |
| }, | |
| { | |
| "symptom": "Polyphagia", | |
| "description": "Increased hunger", | |
| "mechanism": "Cells unable to utilize glucose" | |
| }, | |
| { | |
| "symptom": "Fatigue", | |
| "frequency": "very common" | |
| }, | |
| { | |
| "symptom": "Blurred vision", | |
| "mechanism": "Glucose in lens causes swelling" | |
| } | |
| ], | |
| "diagnostic_criteria": [ | |
| { | |
| "test": "Fasting Plasma Glucose", | |
| "normal": "<100 mg/dL", | |
| "prediabetes": "100-125 mg/dL", | |
| "diabetes": "≥126 mg/dL" | |
| }, | |
| { | |
| "test": "HbA1c", | |
| "normal": "<5.7%", | |
| "prediabetes": "5.7-6.4%", | |
| "diabetes": "≥6.5%" | |
| }, | |
| { | |
| "test": "Oral Glucose Tolerance Test (2-hour)", | |
| "normal": "<140 mg/dL", | |
| "prediabetes": "140-199 mg/dL", | |
| "diabetes": "≥200 mg/dL" | |
| } | |
| ], | |
| "treatment_targets": { | |
| "HbA1c": "<7% (individualized based on patient)", | |
| "fasting_glucose": "80-130 mg/dL", | |
| "postprandial_glucose": "<180 mg/dL", | |
| "blood_pressure": "<140/90 mmHg", | |
| "LDL_cholesterol": "<100 mg/dL" | |
| }, | |
| "medications": [ | |
| { | |
| "class": "Biguanides", | |
| "drug": "Metformin", | |
| "mechanism": "Reduces hepatic glucose production", | |
| "first_line": true | |
| }, | |
| { | |
| "class": "GLP-1 Receptor Agonists", | |
| "examples": ["Semaglutide", "Liraglutide"], | |
| "benefits": ["Weight loss", "Cardiovascular protection"] | |
| }, | |
| { | |
| "class": "SGLT2 Inhibitors", | |
| "examples": ["Empagliflozin", "Dapagliflozin"], | |
| "benefits": ["Weight loss", "Cardiovascular and renal protection"] | |
| }, | |
| { | |
| "class": "Insulin", | |
| "types": ["Rapid-acting", "Long-acting", "Intermediate"], | |
| "indication": "Advanced disease or inadequate control" | |
| } | |
| ], | |
| "complications": { | |
| "microvascular": [ | |
| { | |
| "complication": "Diabetic retinopathy", | |
| "screening": "Annual dilated eye exam" | |
| }, | |
| { | |
| "complication": "Diabetic nephropathy", | |
| "screening": "Annual urine albumin and eGFR" | |
| }, | |
| { | |
| "complication": "Diabetic neuropathy", | |
| "screening": "Annual foot exam" | |
| } | |
| ], | |
| "macrovascular": [ | |
| "Coronary artery disease", | |
| "Stroke", | |
| "Peripheral artery disease" | |
| ] | |
| }, | |
| "lifestyle_management": { | |
| "diet": "Mediterranean or DASH diet, carbohydrate counting", | |
| "exercise": "150 minutes/week moderate-intensity aerobic activity", | |
| "weight_loss": "5-10% body weight can significantly improve glycemic control", | |
| "monitoring": "Self-monitoring of blood glucose as recommended" | |
| } | |
| } | |
| ] | |
| } | |
| ], | |
| "emergency_protocols": { | |
| "chest_pain": { | |
| "action": "Call emergency services immediately", | |
| "first_aid": ["Have patient sit and rest", "Give aspirin if not allergic", "Loosen tight clothing"], | |
| "do_not": ["Give food or drink", "Leave patient alone"] | |
| }, | |
| "severe_asthma_attack": { | |
| "action": "Use rescue inhaler, call emergency if no improvement in 5-10 minutes", | |
| "warning_signs": ["Difficulty speaking", "Blue lips or fingernails", "Severe shortness of breath"] | |
| }, | |
| "hypoglycemia": { | |
| "blood_glucose": "<70 mg/dL", | |
| "symptoms": ["Shakiness", "Sweating", "Confusion", "Rapid heartbeat"], | |
| "treatment": "15g fast-acting carbohydrate (juice, glucose tablets), recheck in 15 minutes" | |
| } | |
| } | |
| } | |
| } | |