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| { | |
| "papers": [ | |
| { | |
| "_file": "paper_a.pdf", | |
| "paper_title": "Test Paper A", | |
| "risk_stance": "acceptable_with_uncertainty", | |
| "risk_confidence": 0.72, | |
| "risk_summary": "Contains partial carcinogenicity evidence.", | |
| "extracted": { | |
| "chemicals": ["Nicotine"], | |
| "genotox_oecd_tg_in_vitro": ["OECD_TG_471_Bacterial Reverse mutation test(AMES test)"], | |
| "genotox_oecd_tg_in_vivo": ["not_reported"], | |
| "genotoxicity_result": "equivocal", | |
| "genotoxicity_result_notes": "AMES mixed outcomes.", | |
| "carcinogenicity_result": "insufficient_data", | |
| "carcinogenicity_notes": "Long-term bioassay absent.", | |
| "dose_metrics": ["NOAEL 10 mg/kg-day"], | |
| "exposure_route": "oral", | |
| "key_findings": "Potential DNA response observed.", | |
| "conclusion": "Needs additional testing." | |
| }, | |
| "evidence": [ | |
| { | |
| "field": "genotoxicity_result", | |
| "quote": "The AMES assay showed equivocal mutagenicity outcomes.", | |
| "pages": "4-5" | |
| }, | |
| { | |
| "field": "dose_metrics", | |
| "quote": "NOAEL was reported at 10 mg/kg-day.", | |
| "pages": "6" | |
| } | |
| ] | |
| } | |
| ], | |
| "toxra_extensions": { | |
| "nlp_diagnostics": [], | |
| "regulatory_gap_assessment": {}, | |
| "risk_calculation_refs": [] | |
| } | |
| } | |