| # Pan-Pancreas PANDA | |
| Multi-dataset corpus for pancreas cell identity + zero-shot transfer + mechanistic discovery. | |
| ## Corpus datasets | |
| | Accession | Study | Cells | Species | Modality | Role | | |
| |---|---|---:|---|---|---| | |
| | GSE132188 | Bastidas-Ponce 2019 | 33,896 | mouse | 10x v2 | Anchor E15.5 endocrine progenitor time course (local) | | |
| | GSE84133 | Baron 2016 | ~10,000 | mouse+human | inDrops | Adult islet reference | | |
| | GSE85241 | Muraro 2016 | ~2,126 | human | CEL-Seq2 | Deep-coverage adult islet | | |
| | E-MTAB-5061 | Segerstolpe 2016 | ~3,514 | human | Smart-seq2 | Deep + T2D covariate | | |
| | GSE81076 | Grun 2016 | ~1,595 | human | CEL-Seq | Modality diversity | | |
| | GSE101099 | Byrnes 2018 | ~12,000 | mouse | inDrops | Independent-lab time course | | |
| ## Held-out labeled validation | |
| **Baron 2016 mouse subset** — has full canonical islet labels (alpha/beta/delta/gamma/epsilon/ | |
| ductal/acinar/endothelial/immune) but is a completely independent scRNA-seq study from a | |
| different lab. Zero-shot transfer of PANDA-pancreas predictions to Baron gives an | |
| apples-to-apples accuracy measurement across labs. | |
| ## Held-out unlabeled discovery target | |
| **Veres 2019 hPSC-directed differentiation (GSE114412)** — human pluripotent stem cell | |
| differentiation to SC-beta cells with an off-target enterochromaffin population. Weakly | |
| labeled by day-of-differentiation only; PANDA's cell-type predictions become hypothesis- | |
| generating annotations. | |
| ## Ontology (11 classes) | |
| - alpha | |
| - beta | |
| - delta | |
| - gamma (PP) | |
| - epsilon | |
| - endocrine-progenitor | |
| - ductal | |
| - acinar | |
| - endothelial | |
| - immune | |
| - other/mesenchymal | |