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| license: apache-2.0 |
| tags: |
| - protein-design |
| - protein-binder-design |
| - generative-model |
| - flow-matching |
| - structure-generation |
| - bioinformatics |
| - computational-biology |
| - protein-engineering |
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| |
| # Model Card for Chamaileon |
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| Chamaileon is a generative framework for **cross-context protein binder design**. It is designed to generate a **single binder sequence** that can bind to multiple protein contexts. |
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| Unlike conventional binder design methods that typically assume a single target and a single structural state, Chamaileon formulates binder generation as **cross-context binding landscape modeling**. This enables the model to address challenging design scenarios such as: |
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| - **Multi-state binder design**, where one binder must remain compatible with multiple conformational states of a target protein. |
| - **Multi-target binder design**, where one binder sequence is optimized to bind multiple related target interfaces. |
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| The official code repository is available at: |
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| https://github.com/caohengyuan/Chamaileon |
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