text stringlengths 330 20.7k | summary stringlengths 3 5.31k |
|---|---|
The geophytic genus Hesperantha Ker Gawl., now with some 88 species is one of the larger genera of subfam.Crocoideae Burnett.Its range extends from southwestern Namibia and the Atlantic coast and near-interior of South Africa through eastern southern Africa to Ethiopia and Cameroon.Most diverse in the southern African ... | The southern and tropical African genus Hesperantha, now with some 88 species, is distinguished in subfam.Crocoideae by the style dividing near or below the mouth of the perianth tube into relatively long style branches and, with a few exceptions, by woody corm tunics.Hesperantha palustris (sect.Concentricae) from mars... |
reaching to the base or lower fourth of the anthers in the closed flower.The slightly succulent foliage leaves are sparsely hairy and have thickened margins and main veins.We discovered a second population of the species in September 2013 on southern slopes of the Keiskie Mtns SE of Calvinia.Flowers in plants maintaine... | We describe three new species from Northern Cape, South Africa discovered in September 2014.Concentricae) from rocky sites, were both collected on the Hantamsberg.We also recognize Hesperantha falcata subsp.lutea for populations with yellow flowers opening during the day and closing in late afternoon.Typical plants of ... |
We propose a fully-convolutional conditional generative model, the latent transformation neural network, capable of view synthesis using a light-weight neural network suited for real-time applications.In contrast to existing conditionalgenerative models which incorporate conditioning information via concatenation, we i... | We introduce an effective, general framework for incorporating conditioning information into inference-based generative models. |
To balance the fish demand of a growing population while respecting the fishing quotas, the aquaculture sector has seen a rapid expansion in these last 30 years.Lately, recirculating aquaculture systems have been developed, allowing to drastically reduce the water consumption per kilo of fish produced.Integrating aquac... | Decoupled aquaponic systems (DAPS) use the wastewater of recirculated aquaculture systems (RAS) as water source for plant production in recirculated hydroponic systems.RAS wastewater is complemented with macro- and micronutrients to obtain equivalent concentrations and pH as in standard hydroponic nutrient solutions (N... |
apparent resistance to salinity.The only possible answer is that RAS wastewater used in the AP treatment should contain factors that were not present in the HP water.Indeed, RAS water is charged with a variety of microorganisms and dissolved organic molecules.The latter are released by physicochemical degradation of th... | Foundation) grown in a NS based on complemented pikeperch RAS wastewater (i.e.AP treatment) has been compared to that of tomatoes grown in conventional hydroponic NS (i.e.Our results clearly indicate the suitability of complemented pikeperch RAS wastewater as feeding water for professional HP tomato production using dr... |
implicated in skeletal muscle disease and desmin-related cardiomyopathy, e.g. caused by the R120G mutation in CRYAB .Overexpression of the latter in a mouse model activates cardiac hypertrophy and Bag3 has been found to regulate contractility and calcium homeostasis in cardiac cells .It is plausible that activation of ... | Cysteine and glycine rich protein 3 (CSRP3) encodes Muscle LIM Protein (MLP), a well-established disease gene for Hypertrophic Cardiomyopathy (HCM).MLP, in contrast to the proteins encoded by the other recognised HCM disease genes, is non-sarcomeric, and has important signalling functions in cardiomyocytes.To gain insi... |
anaesthetic will be disregarded, violating the autonomy principle, in the interest of not harming him/her, preserving the no-harm principle.However, a patient might express the desire to not be resuscitated if his/her heart stops.Under these special circumstances, observing the principle of autonomy should be placed as... | Autonomous systems such as unmanned vehicles are beginning to operate within society.All participants in society are required to follow specific regulations and laws.An autonomous system cannot be an exception.Inevitably an autonomous system will find itself in a situation in which it needs to not only choose to obey a... |
fragments opposed to being fragment-ions of TMTH itself.In this preliminary study we used the shotgun ESI-MS and ESI-MS/MS method for evaluating abundances of steroid metabolites in human urine.TOF-MS and MS/MS analysis of human urine samples revealed abundant peaks corresponding to protonated TMTH derivatised glucuron... | Here we report a new method for oxosteroid identification utilizing "tandem mass tag hydrazine" (TMTH) carbonyl-reactive derivatisation reagent.TMTH is a reagent with a chargeable tertiary amino group attached through a linker to a carbonyl-reactive hydrazine group.Thirty oxosteroids were analysed after derivatisation ... |
The non-stationarity characteristic of the solar power renders traditional point forecasting methods to be less useful due to large prediction errors.This results in increased uncertainties in the grid operation, thereby negatively affecting the reliability and resulting in increased cost of operation.This research pap... | This paper proposes a Unified Recurrent Neural Network Architecture for short-term multi-time-horizon solar forecasting and validates the forecast performance gains over the previously reported methods |
and O3.The results are better for NO and PM, but still we observe variability from sensor to sensor.It is clear that for most citizen applications data quality does not need to reach the same standards necessary for air quality management by authorities or for research.We have computed the match score for the 24 sensor... | The emergence of low-cost, user-friendly and very compact air pollution platforms enable observations at high spatial resolution in near-real-time and provide new opportunities to simultaneously enhance existing monitoring systems, as well as engage citizens in active environmental monitoring.This provides a whole new ... |
The use of alcohols in combination with gelling agents has been increasing in different industrial fields.In the food industry, hydrocolloids are often used with ethanol in both food and beverage products to provide functional properties, such as the system homogeneity and stability over time, the viscosity enhancement... | This work focuses on the understanding of the interaction of alcohols with gel systems during solvent exchange, following the gel formation.A method of widening the possible alcohol contents in formulations is proposed, as most hydrocolloids have a low tolerance of high alcohol concentrations and in some gelation is co... |
ethanol, as it was possible to see when a gradient up to 100% isopropanol/1-propanol was used.Similarly, the measured fracture true strain was 40.4% ± 2.8% for the alcogel treated with a 1-propanol gradient up to 100 wt% and 39.5% ± 3.2% for isopropanol.Since the gel shrinkage for isopropanol and 1-propanol was compara... | It is the first time that a research paper considers the high-alcohol/gellan gum systems at both the molecular and macroscopic scales, proposing the link between them.From this study, the solvent effect on the gelling agent is evident, leading to structure shrinkage and distortion due to a high-induced stress on the ge... |
combination of a significantly reduced chipping wear on the flank face and the minimal crater wear on the rake face obtained with the M-steel in this study indicates that a higher CBN content tool grade can be used with this steel.High CBN content PCBN grades are often considered tougher, yet more susceptible to wear b... | This study describes the influence of the steel characteristics of Ca-treated carburising steel grades during hard part turning of synchronising rings in gearbox production.The main focus was on the chemical composition of the non-metallic inclusions in the evaluated workpieces and their effect on the PCBN tool wear.In... |
as only one sample from site M met the reliability criteria, this flow was not included in our result.No samples from site T, T and S2 meet all the reliability criteria.The selected samples have shown corresponding distinct directional components, positive pTRM checks, no significant curvature of the Arai plots and lit... | The samples display corresponding distinct directional components, positive pTRM checks and little or no zig-zagging of the Arai or Zijderveld plot, providing evidence to support that the samples are not influenced by lab-induced alteration or multi-domain behavior.The accepted microwave paleointensity results from thi... |
three regions- the two northern regions which have distinct but correlatable stratigraphy, and the southeastern region which contains the sills from the areas around the kimberlite pipes Sytikanskaya, Yubileinaya and Aikhal.To test the robustness of the geomagnetic means from these regions, sites were filtered out base... | The quantity of igneous material comprising the Siberian Traps provides a uniquely excellent opportunity to constrain Earth's paleomagnetic field intensity at the Permo-Triassic boundary.There remains however, a contradiction about the strength of the magnetic field that is exacerbated by the limited number of measurem... |
level of the discrete quantitative variable ‘Age’ has been analysed by comparing means through Snedecor's F distribution non-considering equality of variances. "For the rest of the nominal and ordinal variables, as purely quantitative analyses could not be carried out, Chi-squared test was conducted on contingency tabl... | The relationship between twelve variables was analysed comparing means through the Snedecor's F distribution and the contingency tables through the Chi-squared test and Somers’ D. Among other issues, it was concluded that the virtual reality user profile at present corresponds to a person older than 36, mainly men, wit... |
and necessary.Without them, these first green shoots could wither on short notice and this relationship could get cold and be wasted in the future.Another problem to be faced in the future for the use of virtual reality as a learning tool is accessibility to groups of students.Currently, teachers participating in this ... | This study describes the social and demographic profile of the first generation of users of marketed virtual reality (VR) viewers in Spain and, subsequently, it assesses the interest in its use as a learning tool.Concerning the interests of virtual reality users as a learning tool, only a few of them currently use virt... |
In this paper, we present an approach to learn recomposable motor primitives across large-scale and diverse manipulation demonstrations.Current approaches to decomposing demonstrations into primitives often assume manually defined primitives and bypass the difficulty of discovering these primitives.On the other hand, a... | We learn a space of motor primitives from unannotated robot demonstrations, and show these primitives are semantically meaningful and can be composed for new robot tasks. |
s and over 1000 ng/mL samples).Based on these results, we decided to mix samples and the ISD pretreatment reagent for 180 s.The within-assay and day-to-day assay precision for 3 different whole blood controls were tested.Day-to-day assay precision was investigated by performing the assay on 10 days over a two-week peri... | Results Within-assay coefficients of variation were 1.8−3.6% (CsA: 94−1238 ng/mL) and 2.9−3.9% (TAC: 2.1−17.8 ng/mL), whereas day-to-day coefficients of variation ranged between 3.0−4.1% (CsA) and 2.8−3.9% (TAC).A method comparison using a standardized major axis regression analysis of ACMIA and ECLIA was r=0.995, y=0.... |
over 500 ng/mL samples with the high concentration measurement mode “CSAE”, which is the reagent for measuring high concentration of CsA.If measurement is performed using reagents immediately after dissolution of the reagent, there is a possibility that the measurement result may fluctuate largely.Thus, our results may... | Background Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs that are often used to treat autoimmune diseases and as transplantation therapy; therefore, their concentrations need to be monitored carefully.We herein evaluated the analytical performance of the Elecsys® Cyclosporine and Elecsys® Tacrolim... |
the thoracic target with the size of the error being more prominent in the AEP and PEP.In the pelvis, all three LBP subgroups overestimated the target, with a pelvis tilted anteriorly as a result compared to no-LBP.The baseline classifier was created from the repositioning sense data of the no-LBP individuals.The Cardi... | 87 LBP subjects, clinically subclassified into flexion (n = 50), passive extension (n = 14), and active extension (n = 23) motor control impairment subgroups and 31 subjects with no LBP were recruited.From no-LBP, subsets of flexion LBP, active extension and passive extension achieved 93.83, 98.15% and 97.62% accuracy,... |
of evaluating the impact of therapies on clinically important function outcomes.Interestingly, the nature of repositioning sense deficits reflected the LBP subsets pain presentation pattern.For example, the highest ranking RE in AEP and PEP was in standing, principally reported as most pain provoking posture in these s... | Background: Low back pain (LBP) classification systems are used to deliver targeted treatments matched to an individual profile, however, distinguishing between different subsets of LBP remains a clinical challenge.Methods: A novel application of the Cardiff Dempster–Shafer Theory Classifier was employed to identify cl... |
The intracellular organization of all eukaryotic cells are variations on a basic theme of membrane compartmentalization.Within this theme there is remarkable diversity across the eukaryotic tree of life .Many microbial eukaryotes, especially parasites with extreme lifestyle adaptations, have particularly exotic endomem... | Microbial eukaryotes present a stunning diversity of endomembrane organization.From specialized secretory organelles such as the rhoptries and micronemes of apicomplexans, to peroxisome-derived metabolic compartments such as the glycosomes of kinetoplastids, different microbial taxa have explored different solutions to... |
possible genomes.Most such genomes are not viable, but some result in functional traffic rules through molecular interactions.These rules then generate the steady-state traffic system, with some set of compartments interconnected by vesicles.We cannot fully know the complexities of mutation, selection and drift, nor th... | Here we argue that traffic systems of high complexity could arise through non-adaptive mechanisms via purely physical constraints, and subsequently be exapted for various taxon-specific functions.Sampling at random from among such rules represents an evolutionary null hypothesis: any properties of the resulting cells m... |
on a different epitope from the capture antibody.A conjugated enzyme was added into the assay.After incubation periods and wash steps specified by every supplier to remove unbound antibody from the plate, a substrate solution was added in order to obtain a measurable signal.The intensity of this signal was proportional... | Centrosomal abnormalities, in particular centrosome amplification, are recurrent features of human tumors.Enforced centrosome amplification in vivo plays a role in tumor initiation and progression.However, centrosome amplification occurs only in a subset of cancer cells, and thus, partly due to this heterogeneity, the ... |
to improve parts of the CRISPR system; new producer strains can be obtained from marine sources and modified/improved using CRISPR.CRISPR/Cas systems can contain genes that encode highly divergent proteins.All these are a valuable source for the synthetic biology.There are at least two studies which presented CRISPR-ba... | This review summarizes usage of genome-editing technologies for metagenomic studies; these studies are used to retrieve and modify valuable microorganisms for production, particularly in marine metagenomics.The novel genes, pathways and genomes can be deducted.Therefore, metagenomics, particularly genome engineering an... |
are an accredited laboratory and therefore have rigorous quality assurance procedures.Briefly, soils were air dried at 35 °C and sieved to <2 mm.These dried and sieved samples were then composited and analysed for ‘total’ heavy metals using a conc.HNO3/HCl digestion and analysed using ICP-MS.While the detection limits ... | Some 46% of the urban garden samples had Pb concentrations higher than the residential land use national standard of 210 mg kg−1, with the most contaminated soil containing 2615 mg kg−1 Pb.Concentrations of As and Zn exceeded the residential land use national standards (20 mg kg−1 As and 400 mg kg−1 Zn) in 20% of the s... |
other cities, a significant number of suburban soils from Christchurch gardens were above the national standards for HM concentrations, particularly soils from older neighbourhoods.Unlike some other cities, many suburban soils are used for food production.While we did not test food crops from suburban gardens in this s... | Numerous studies have shown that urban soils can contain elevated concentrations of heavy metals (HMs).Christchurch, New Zealand, is a relatively young city (150 years old) with a population of 390,000.Most soils in Christchurch are sub-urban, with food production in residential gardens a popular activity.Earthquakes i... |
In this paper, we investigate learning the deep neural networks for automated optical inspection in industrial manufacturing.Our preliminary result has shown the stunning performance improvement by transfer learning from the completely dissimilar source domain: ImageNet.Further study for demystifying this improvement s... | We experimentally show that transfer learning makes sparse features in the network and thereby produces a more compressible network. |
which are needed to develop the best drugs possible for Chagas patients.Given the amount unknown in the field this is not an easy task.Box 2 depicts a few priorities that might be worth considering for the future.The immediate priority should be to better characterize the two current drugs available for the disease wit... | Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi.Although it was first identified more than a century ago, only two old drugs are available for treatment and a lot of questions related to the disease progression, its pathologies, and not to mention the assessment... |
benefits to such an alternative.We have focused upon decisions relating to a supplier newly integrated to a company’s supply base in a context where the lead times allow for both learning and improvement activities to be initiated before the regular supply of parts starts.However, a related problem is that of developin... | We consider supplier development decisions for prime manufacturers with extensive supply bases producing complex, highly engineered products.We propose a novel modelling approach to support supply chain managers decide the optimal level of investment to improve quality performance under uncertainty.We develop a Poisson... |
used as a screener and not as a gold-standard measure of child development.However, these measures have been complemented with more reliable direct measures such as the Woodcock-Muñoz and anthropometric measures.Third, we did not collect daily attendance data, which prevents us from studying more rigorously the effects... | Colombia's national early childhood strategy launched in 2011 aimed at improving the quality of childcare services offered to socio-economically vulnerable children, and included the possibility that children and their childcare providers could transfer from non-parental family daycare units to large childcare centers ... |
adhesion and needs further investigation.A comparative analysis of patterned and random nanotopographies affecting the bactericidal activity could enhance the current state of understanding in this field.Aside from surface roughness, the other critical parameters that should be studied and correlated with the bacterici... | Toward minimizing bacterial colonization of surfaces, we present a one-step etching technique that renders aluminum alloys with micro- and nano-scale roughness.Such a multi-scale surface topography exhibited enhanced antibacterial effect against a wide range of pathogens.Multi-scale topography of commercially grade pur... |
authors contributed to the review and drafting of the paper.We declare no competing interests.In this case series analysis, we examined all melioidosis cases diagnosed by the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, from October, 1999, to August, 2015, and all culture-confirmed melioidosis cases ... | Methods: We examined the records of patients diagnosed with melioidosis at the Microbiology Laboratory of Mahosot Hospital in Vientiane, Laos, between October, 1999, and August, 2015, and all patients with culture-confirmed melioidosis presenting to the Angkor Hospital for Children in Siem Reap, Cambodia, between Febru... |
these variables were examined simultaneously in a multivariable regression model, only humidity, low visibility, and maximum wind speed remained significantly associated with melioidosis admissions.In univariable regression analyses, melioidosis admissions in Cambodia were significantly associated with humidity, minimu... | Melioidosis incidence is highly seasonal.Melioidosis cases were significantly associated with humidity (p<0.0001), low visibility (p<0.0001), and maximum wind speeds (p<0.0001) in Laos, and humidity (p=0.010), rainy days (p=0.015), and maximum wind speed (p=0.0070) in Cambodia.Compared with adults, children were at sig... |
and one might suspect that these patients would be particularly susceptible during months with high environmental exposure.32,33,One possible explanation would be that patients with known diabetes had better controlled disease than did those with potentially undiagnosed diabetes; however, significantly higher average b... | We aimed to identify the climatic drivers of infection and to shed light on modes of transmission and potential preventive strategies.Lung and disseminated infections were more common during windy months.Our findings highlight the risks of infection during highly humid and windy conditions, and suggest a need for incre... |
the pertinent tumor–immune interface.In one study 92% concordance between biopsy and resection was reported , while in another the concordance rate was much lower with underestimations found with small biopsies .In this study SP142, a slightly less sensitive antibody, was used and also evaluated immune cells.Because in... | In summary, the PD-L1 biomarker discussed here highlights the importance of understanding the practice of IHC.This can be used to the patients advantage, with appropriate usage.The currently available literature on PD-L1 IHC from a methodologic point of view has not shown that different assays are comparable.The route ... |
Periostin is a 90 kD matricellular protein with well-described roles in osteology, tissue repair, oncology, cardiovascular and respiratory systems, as well as inflammatory processes .Periostin interacts with signaling pathways and controls the expression of downstream genes that regulate cellular interactions within th... | Objective The multifunctional cytokine IL-13 is thought to play a central role in Type 2 inflammation in asthma.Serum periostin has been explored as a candidate biomarker for evaluating IL-13 activity in the airway.We describe the technical performance characteristics of a novel, fully automated immunoassay for the det... |
to keep the specificity of the assay.Furthermore, standardization procedures were implemented to ensure a comparable readout with both assay versions.The method comparison experiment indicates that there are no relevant systematic differences between both versions of the assay.For the final version of the Elecsys® Peri... | Design and methods Limit of blank [LoB], limit of detection [LoD] and limit of quantitation [LoQ], linearity, precision and reproducibility across sites and lots were evaluated according to Clinical and Laboratory Standards Institute guidelines.Interferences and sample stability were also investigated.Results The pre-s... |
Air pollution monitoring requires high-precision instruments, which are expensive and often limit the number of locations observed .In addition to financial constraints, time constraints presented by monitoring multiple sites with a limited number of monitors often prevent long-term continuous monitoring, which is requ... | Mobile air pollution monitoring is an effective means of collecting spatially and temporally diverse air pollution samples.These observations are often used to predict long-term air pollution concentrations using temporal adjustments based on the time-series of a fixed location monitor.Temporal adjustments are required... |
were saved into a separate folder for quantification.Systematic random sampling and unbiased stereological methods were used for quantification as adopted from previously published studies .Six raw tiles were chosen from area of interest for quantification, the first raw tile was always included, and 5 other raw tiles ... | Microinjection of the μ-opioid receptor (MOR) agonist DAMGO (30 ng) into the PAG of Sprague-Dawley rats increased spinal excitability and lowered mechanical threshold to noxious stimuli in postnatal day (P)21 rats, but had inhibitory effects in adults and lacked efficacy in P10 pups.A tonic opioidergic tone within the ... |
anaesthetised rats, which are routinely used in studies investigating pain control in neonates .This experimental preparation removes confounding factors such as handling stress, novel testing environment, and perhaps most importantly, the effects of a protracted period of maternal separation, which are known to signif... | Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control of spinal excitability via the dorsal horn (DH).Spinal adminstration of DAMGO inhibited spinal excitability in all ages, y... |
and FAO on the 21st of February.This document provided detailed information about the evolution and expected impacts of the drought.Critical food security and the need of humanitarian assistance were repeatedly confirmed in the following months and persisted at the time of writing this manuscript.A number of improvemen... | Rainfall estimates provide an outlook of the drivers of vegetation growth, whereas time series of satellite-based biophysical indicators at high temporal resolution provide key information about vegetation status in near real-time and over large areas.The new early warning decision support system ASAP (Anomaly hot Spot... |
management is not likely to succeed unless there are significant tangible benefits to forest dependent communities in the vicinity of these forests.Furthermore, the relationships between the ability to obtain a forest based income and engagement in forest management groups are not always linear and need to be further i... | We address this research gap by quantifying the broader suite of ecosystem services that support small holder farmers and identifying farmers’ knowledge of storm hazard reduction benefits provided by forest fragments in Madagascar.Using multivariate statistics, results show a heavy dependence on forests for food and ra... |
begin to appear.Rapid progress is being made in molecular stratification for IBD, which is now beginning to allow prediction of disease severity and the risk of developing complications.Currently the best potential stratification strategies utilise serological and faecal markers.Few transcriptomic and metabolomic studi... | Inflammatory bowel disease (IBD) is a debilitating chronic inflammatory disease of the gastrointestinal (GI) tract.IBD is highly heterogeneous; disease severity and outcomes in IBD are highly variable, and patients may experience episodes of relapse and remission.However, treatment often follows a step-up model whereby... |
Dioscorea schimperiana is one of the nine commonly consumed yams in Cameroon.This yam is an integral crop for food security in the west regions where it is grown.It is the only yam with a traditional and well defined drying technology.Therefore, it became a concern when it was considered as endangered yam specie despit... | Challenges remain the difficulty in formulating nutritionally adequate diets.Flours from dried yam slices bought on local market were fortified with soybean and groundnut paste to develop a balanced diet.Carrot and egg shell were added as reinforcing sources of micronutrients.The nutritional content and antioxidant pro... |
to increase the sweetness .Correlational analysis was carried out to assess the linear relationship between the color of the yam flesh and the Carotenoids and alpha tocopherol contents.There was a positive correlation between the color of yam and the level of ß-criptoxanthine, zeaxanthin.This linear correlation was sig... | This study was carried out to investigate the effect of Dioscorea schimperiana flesh color on nutritional composition and antioxidant activity of formulated yam based complementary food.The amount of carotenoids, α tocopherol, total phenols, zinc and iron in yam-based formulations depended on the color of the yam flesh... |
size of an infant's stomach.Their protein and lipids daily quantity requirement would also be satisfied when eating the formulated flours, since the value of the estimated daily proteins and fat intake from yam based complementary food are higher than the suggested intake at the age range of 6–24 months.WHO/FAO has est... | Childhood malnutrition is a current and perpetual public health concern in many African countries.Results indicate the flour blendes satisfy the recommended energy and macronutrients requirements according to set standards.Thus the flour blends can be used for managing protein-energy malnutrition.The red-fleshed yam ba... |
urea formaldehyde, used here as the binder for printing, is not suitable for products intended for outdoor use because prolonged moisture exposure leads to a breakdown of bond-forming reactions.However, there are other formaldehyde-based adhesives, such as phenol and melamine formaldehyde, which do not break down when ... | In contrast to subtractive manufacturing techniques, additive manufacturing processes are known for their high efficiency in regards to utilisation of feedstock.However the various polymer, metallic and composite feedstocks used within additive manufacturing are mainly derived from energy consuming, inefficient methods... |
after 3 years.Finally, the slope of the measured average vertical strain curves in July 2016 were fitted by changing the contribution from the creep, i.e. the μ∗/λ∗-ratios.This process was repeated until a good fit was obtained.The effect of changing the different parameters is demonstrated in Fig. 11.The figure shows ... | The paper describes the Class A prediction and Class C back-calculations of the Ballina test embankment using the finite element program Plaxis and the Soft Soil Creep Model (SSCM).The prediction underestimated the measured settlement 3 years after construction by about 20%.This was mainly due to too high stiffness in ... |
Dataset provides raw descriptive and inferential statistics on the relationship between Ethical Leadership and Corporate Reputation.Figs. 1–4 provide data on selected characteristics of the sample, such as gender, age, years spent on the job and highest education level attained.Table 1 provides the validity test result... | Banking institutions play a critical role in any economy, and their stability is crucial to the economic development of a nation.The wave of corporate scandals that rocked the industry left the public with a loss of confidence.Efforts have since been channeled by banks towards developing their corporate governance mech... |
report and measure.Specifically, onset delay is a construct addressing timing, given an intention to act.Even if there may be various specific reasons for delaying onset, the result as perceived by the actor is a failure to start as intended.In contrast, delays during task execution may be due to diverse and complex fa... | We trace this failure to an imprecise understanding of “delay,” another core concept in procrastination.In two studies (aggregated N = 465) we demonstrate, using exploratory and confirmatory factor analysis, that although onset and sustained action procrastination measures correlate, they are still separate facets of i... |
uncertainty are spectral interference, counting statistics, and energy dependence of the detection efficiency, mainly due to backscattering.For an accurate determination of the emission probabilities, a correction for energy dependence of the detection efficiency should be applied.In this work, Monte Carlo simulations ... | Internal conversion electron (ICE) spectra of thin 238,239,240Pu sources, measured with a windowless Peltier-cooled silicon drift detector (SDD), were deconvoluted and relative ICE intensities were derived from the fitted peak areas.Corrections were made for energy dependence of the full-energy-peak counting efficiency... |
In 1967, an outbreak of smallpox occurred in the Nigerian town of Abakaliki.The vast majority of cases were members of the Faith Tabernacle Church, a religious organisation whose members refused vaccination.A World Health Organization report describes the outbreak, with information on not only the time series of case d... | The data themselves continue to be of interest due to concerns about the possible re-emergence of smallpox as a bioterrorism weapon.We present the first full Bayesian statistical analysis using data-augmentation Markov chain Monte Carlo methods which avoid the need for likelihood approximations and which yield a wider ... |
the compounds, could well have been rather less than that assumed in the model.According to Thompson and Foege, the FTC community was largely isolated from the community at large, although several of its adult members were involved in trading activities in and around Abakaliki.Consequently, a model in which some fracti... | The celebrated Abakaliki smallpox data have appeared numerous times in the epidemic modelling literature, but in almost all cases only a specific subset of the data is considered.The only previous analysis of the full data set relied on approximation methods to derive a likelihood and did not assess model adequacy.Our ... |
The decision on the construction of the European Spallation Source initiated a number of studies on the instrumentation for a long pulse neutron source.It will provide an exciting opportunity to design a reflectometer of the next generation to meet the increasing demand and anticipated scientific challenges .In several... | It is constitutes a new class of reflectometers achieving the unprecedentedly high flux for classical specular reflectometry combined with off-specular reflectometry and grazing incidence small-angle scattering (GISANS), thus resulting in a complete 3-d exploration of lateral and in depth structures in thin films.The u... |
reflectometry permit studies of lateral structures in an extremely wide range from 0.4 to 30 µm.All the above allow for a gap-less exploration of the Q-space of thin interfaces in all 3 directions.The full polarisation analysis in combination with the high flux will push the limits of signal to noise ratio for samples ... | The instrumental concept of HERITAGE – a reflectometer with a horizontal sample geometry – well fitted to the long pulse structure of a neutron source is presented.This is achieved by specially designed neutron guides.In the horizontal direction (perpendicular to the scattering plane) the guide's elliptic shape focusse... |
60 provided by the HERITAGE design as compared to the today's strongest neutron sources in comparable conditions offers great opportunities in the field of neutron reflectometry.It may lead to a drastic reduction of the measurement time, allowing for instance a detailed mapping of a phase diagram of a sample, which is ... | This concept assures the delivery of the maximum possible and usable flux to the sample in both reflectivity and GISANS measurement regimes.The presented design outperforms the flux of all present-day and already for the ESS planned reflectometers and GISANS setups in flux and in measuring time for standard samples. |
and the water droplet distribution of the impact depends on the area covered by the water droplet.To analyze the spray uniformity of water distribution, the nozzle spacing Sn and the heights between the nozzle and coil H are adjusted.In this work, to investigate the water spray uniformity of the sprinklers, Table 1 sho... | This study aims to investigate the water spray uniformity and collection ratio of sprinkler in an evaporative condenser of a water chiller.Experiments of water droplet distribution are conducted with 50 water collectors during the tests.Three different combinations of nozzle opening length and width were tested with th... |
marine fuel combustion, is this not an opportunity to address the challenges of sulphur and CO2 together?,Links between SOx and CO2 emissions mean the sector runs the risk of taking a very short-sighted approach if chooses to tackle SOx emissions without thought for the carbon repercussions.Addressing the co-benefits w... | Although this is demanding, a greater challenge for all sectors is climate change.With a deep-seated change to the type of fuel burnt in marine engines, this should be seen as an opportunity to explore co-benefits of sulphur and carbon reduction - instead of taking a short-sighted approach to the problem.It is argued h... |
in-stent restenosis.Of particular relevance is the ability of EPAC1 to induce SOCS3 gene expression, as SOCS3 exerts multiple protective effects in both cell types, while immunohistochemical studies have shown that neointimal lesions from a pig coronary artery injury model have significantly lower SOCS3 expression leve... | Pharmaceutical manipulation of cAMP levels exerts beneficial effects through the regulation of the exchange protein activated by cAMP (EPAC) and protein kinase A (PKA) signalling routes.Recent attention has turned to the specific regulation of EPAC isoforms (EPAC1 and EPAC2) as a more targeted approach to cAMP-based th... |
Providing transparency of AI planning systems is crucial for their success in practical applications.In order to create a transparent system, a user must be able to query it for explanations about its outputs.We argue that a key underlying principle for this is the use of causality within a planning model, and that arg... | Argumentation frameworks are used to represent causality of plans/models to be utilized for explanations. |
practice’.Farmers are aware that they often overuse anthelmintic drugs, that this seems to be a product of inherited practices over the years, and that it might mean that their practices are unsustainable.The process of perpetuating established social norms in farming thus play a key role in maintaining the rules of th... | Farm practices related to drug use in animal agriculture play an important role in the development of drug resistance.In this paper, I use Bourdieu's theory of practice to explore the field of deworming and how the use of deworming medications, also called anthelmintics, by farmers may be a pragmatic choice within the ... |
while amygdala activity increased.Activity in the secondary somatosensory cortex, posterior insula, ACC, and caudate nucleus was correlated with the heat stimulation, while only right anterior insula activity correlated with the heat stimulation during tVNS.The anterior insula has been implicated in modulating the perc... | There is preclinical and clinical evidence that vagus nerve stimulation modulates both pain and mood state.Mechanistic studies show brainstem circuitry involved in pain modulation by vagus nerve stimulation, but little is known about possible indirect descending effects of altered mood state on pain perception.To date,... |
least a 4-fold increase in post-vaccination reciprocal titer.SPR was defined as the percentage of participants who attained reciprocal HI titers of ≥1:40.MGI was defined as the geometric mean of the within-subject ratios of the post-vaccination/pre-vaccination reciprocal HI titer.For the PPV23, anti-pneumococcal antibo... | Immunogenicity was assessed by hemagglutination inhibition (HI) titers for IIV4 and 22F-inhibition ELISA for PPV23.Co-primary objectives were to demonstrate non-inferiority of co-administration versus separate administration in terms of geometric mean titer (GMT) ratio for each influenza strain in the IIV4 and geometri... |
in Europe that are associated with invasive disease .With regard to the secondary objectives, all estimated immunogenicity parameters for all four influenza vaccine strains and all 12 pneumococcal serotypes evaluated were similar with co-administration and separate administration.We also evaluated immunogenicity of the... | Introduction We compared co-administration versus separate administration of an inactivated quadrivalent influenza vaccine (IIV4) with a 23-valent pneumococcal polysaccharide vaccine (PPV23) in adults at high risk of complications of influenza and pneumococcal infection.Immunogenicity of the IIV4 and PPV23 was similar ... |
Autosomal dominant diseases represent a challenge for development of effective therapies.Whereas haploinsufficiency may be treated by conventional gene replacement, diseases linked to gain-of-function or toxic effect in essential proteins require the targeting of the mutated allele.The mutated allele can be either inac... | Genome editing with the CRISPR/Cas9 technology has emerged recently as a potential strategy for therapy in genetic diseases.In this study, we tested allele-specific inactivation or correction of a heterozygous mutation in the Dynamin 2 (DNM2) gene that causes the autosomal dominant form of centronuclear myopathies (CNM... |
Capsule Networks have shown encouraging results on benchmark computer vision datasets such as MNIST, CIFAR and smallNORB.Although, they are yet to be tested on tasks where the entities detected inherently have more complex internal representations and there are very few instances per class to learn from and where point... | A pairwise learned capsule network that performs well on face verification tasks given limited labeled data |
studies and is more effective when combined with others measures, especially bone debridement and/or surgery.Unlike ORN, protocol with PENTO associated with ATB did not show good results in healing of MRONJ.In contrast, platelet-rich plasma was also a good treatment alternative, succeeding in over 80% of cases.Low-leve... | Introduction: Osteonecrosis of the jaws can result either from radiation, used in radiotherapy for treatment of malignant tumors, or medications used for bone remodeling and anti-angiogenesis such as bisphosphonates.These conditions can be associated with triggering factors such as infection, trauma and decreased vascu... |
Children, especially those aged <5 years, are at the highest risk of suffering from serious complications from influenza infection, including acute otitis media,1 bacterial co-infections, acute respiratory infection, hospitalisation, and death .Severe outcomes of influenza are frequently associated with underlying cond... | Methods: Data collected during the phase III trial were analysed to examine the vaccine efficacy (VE) of IIV4 in preventing laboratory-confirmed influenza in age subgroups and to determine the relative risk for IIV4 vs. placebo for severe outcomes, healthcare use, and parental absenteeism from work associated with labo... |
IIV4 or placebo, as described previously .The IIV4 and placebo groups were balanced for sex, age, and prevalence of at-risk conditions, regions, and ethnicities.Five participants in the IIV4 group and 16 in the placebo group had AOM associated with laboratory-confirmed influenza, and five participants in the IIV4 group... | Background: A multi-season phase III trial conducted in the Northern and Southern Hemispheres demonstrated the efficacy of a quadrivalent split-virion inactivated influenza vaccine (IIV4) in children 6–35 months of age.Results: VE (95% confidence interval [CI]) to prevent laboratory-confirmed influenza due to any A or ... |
In this paper, we propose a novel technique for improving the stochastic gradient descent method to train deep networks, which we term .The proposed PowerSGD method simply raises the stochastic gradient to a certain power during iterations and introduces only one additional parameter, namely, the power exponent.We furt... | We propose a new class of optimizers for accelerated non-convex optimization via a nonlinear gradient transformation. |
Complex and unstructured problems like speech or image recognition are currently solved most effectively on by deep learning algorithms running on specialized electronic circuits such as graphical processing units .The extensive computation effort on these standard von-Neumann computer architectures requires however ma... | New computation schemes inspired by biological processes are arising as an alternative to standard von-Neumann architectures, to provide hardware accelerators for information processing based on a neural networks approach.As previously shown, these oscillating neural networks can efficiently solve complex and unstructu... |
required to understand the dynamics that cause this behavior: the first device changes to the metallic state and the output voltage Vosc3 stays fixed at a value slightly larger than the threshold voltage VTL2, necessary to trigger the metal to insulator transition.The threshold is reached only when the first device als... | Systems of frequency-locked, coupled oscillators are investigated using the phase difference of the signal as the state variable rather than the voltage or current amplitude.Coupling these oscillators with an array of tunable resistors offers the perspective of realizing compact oscillator networks.In this work we show... |
that there are a number of key controls on fracture reactivation, many of which need further investigation.Using a Bowland Shale gouge, which was shown to have a high carbonate content, we have defined the mechanical and reactivation properties of the gouge.When comparing these results to tests on other mineralogy goug... | During the hydraulic stimulation of shale gas reservoirs the pore pressure on pre-existing faults/fractures can be raised sufficiently to cause reactivation/slip.There is some discrepancy in the literature over whether this interaction is beneficial or not to hydrocarbon extraction.Some state that the interaction will ... |
easily accommodate 10 kHz systems, but scaling to 100 kHz lasers will require a more careful study of laser-induced damage to the fiber.Our current system produces a fixed set of wavelengths.Continuous wavelength tuning between 1190 and 1225 nm could be possible by combining two lasers inside the fiber, as shown in Fig... | We demonstrate optical resolution photoacoustic microscopy (OR-PAM) of lipid-rich tissue using a multi-wavelength pulsed laser based on nonlinear fiber optics.1047 nm laser pulses are converted to 1098, 1153, 1215, and 1270 nm pulses via stimulated Raman scattering in a graded-index multimode fiber.Multispectral PAM of... |
South Africa has poor health outcomes given its level of economic development.1,2,Despite being an upper-middle-income country,3 South Africa has high mortality levels resulting from a unique quadruple disease burden, described in the first National Burden of Disease study in 2000.4, "The 2009 Lancet Series on Health i... | Background The poor health of South Africans is known to be associated with a quadruple disease burden.In the second National Burden of Disease (NBD) study, we aimed to analyse cause of death data for 1997–2012 and develop national, population group, and provincial estimates of the levels and causes of mortality.Interp... |
to the changing cardiovascular disease risk profile associated with antiretroviral therapy;39 therefore integrated management is essential.The decline in overall injury death rates can be attributed largely to a decrease in deaths from interpersonal violence between 1997 and 2012.The decrease in firearm homicide25 has ... | Injury deaths were estimated from additional data sources.Comparison with the IHME GBD estimates for South Africa revealed substantial differences for estimated deaths from all causes, particularly HIV/AIDS and interpersonal violence.Differences between GBD estimates for South Africa and this study emphasise the need f... |
a bottom-up approach.However observed differences between the South Africa NBD study and the IHME GBD study could not be resolved by IHME because of the restrictions of their global and regional modelling approaches.The South African NBD team with local and international experts revised the 2000 NBD list to reflect loc... | Method We used underlying cause of death data from death notifications for 1997–2012 obtained from Statistics South Africa.These data were adjusted for completeness using indirect demographic techniques for adults and comparison with survey and census estimates for child mortality.A regression approach was used to esti... |
the deaths were attributed to non-communicable diseases, 33·6% to HIV/AIDS and tuberculosis, 13·5% to other communicable diseases, perinatal conditions, maternal causes, and nutritional deficiencies, and 9·6% to injuries.The all-cause age-standardised death rates increased from 1215 per 100 000 population in 1997 to pe... | Findings All-cause age-standardised death rates increased rapidly since 1997, peaked in 2006 and then declined, driven by changes in HIV/AIDS.Mortality from tuberculosis, non-communicable diseases, and injuries decreased slightly.In 2012, HIV/AIDS caused the most deaths (29.1%) followed by cerebrovascular disease (7.5%... |
and isotype controls IgG1, IgG2a and IgG2b, all in 2% bovine serum albumin/phosphate buffered saline.After washing with 2%BSA/PBS, cells were further incubated for 30 min with either goat anti-mouse IgG2b-RPE, goat anti-mouse IgG2a-RPE, or goat anti-mouse IgG-FITC secondary antibodies.Following washing samples were ana... | GPR15/BOB expression on peripheral blood leukocytes was analysed by flow cytometry and GPR15/BOB messenger RNA was examined in peripheral blood monocytes by RT-PCR.GPR15/BOB protein was observed in CD68+ and CD14+ macrophages in synovia, with greater expression in RA synovia.GPR15/BOB protein was expressed in all patie... |
from the PB of healthy donors.GPR15/BOB mRNA was detected in isolated monocytes/macrophages from these individuals.Infiltration of the synovial membrane by inflammatory leukocytes is a characteristic pathological feature in rheumatoid arthritis patients.Leukocytes including macrophages are recruited by the action of ch... | Chemokine receptors on leukocytes mediate the recruitment and accumulation of these cells within affected joints in chronic inflammatory diseases such as rheumatoid arthritis (RA).Identification of involved receptors offers potential for development of therapeutic interventions.The objective of this study was to invest... |
in Table 6 for a carboxylate solution and paper mill wastewater.Table 6 shows that the desorption method is effective for the five different carboxylates studied.High methyl ester yields are obtained for the smaller carboxylates, and the yield decreases with the increase in molecular size.This result is comparable to r... | This paper describes a new option for integrated recovery and esterification of carboxylates produced by anaerobic digestion at a pH above the pKa.The carboxylates (acetate, propionate, butyrate, valerate and lactate) are recovered using a strong anion exchange resin in the bicarbonate form, and the resin is regenerate... |
gamma pulses and 1% of gamma pulses were identified as alpha pulses.The pulse area is directly proportional to the deposited energy.The detector was calibrated with an unsealed 241Am α-source with 5.486 MeV.The resulting ionisation energy of the diamond detector was 12 eV/eh-pair.This calibration applies to all particl... | Spectra of the alpha particles and tritons of <sup>6</sup>Li(n,T)<sup>4</sup>He thermal neutron capture reaction were separated from the gamma background by a new algorithm based on pulse-shape analysis.The thermal neutron capture in <sup>6</sup>Li is already used for neutron flux monitoring, but the ability to remove ... |
which is reported as 86.2 m.s−1 in the study.It is worth noting that an experimental investigation on the MILD-oxy combustion of pulverized coal at ordinary temperatures was conducted at a 0.4 MW pilot-scale facility at HUST.MILD-oxy combustion of pulverized coal was successfully achieved without highly preheating the ... | Oxyfuel combustion with carbon capture and sequestration (CCS) is a carbon-reduction technology for use in large-scale coal-fired power plants.Significant progress has been achieved in the research and development of this technology during its scaling up from 0.4 MWth to 3 MWth and 35 MWth by the combined efforts of un... |
et al. fabricated AuNP containing TiO2 NF DSSCs and achieved a PCE of 7.8%, improving their control NF PECs by 15%, which was similar to the improvement margin demonstrated in this work.However, they did not control the particle size of their AuNPs.In contrast to existing reports, we provide a compressive performance e... | Incorporation of gold nanoparticles (AuNPs) into titanium dioxide (TiO2) photoelectrodes has been used traditionally to increase the performance of photoelectrochemical cells (PECs) through their tailored optical properties.In contrast to larger AuNPs, previous studies have suggested that smaller AuNPs are the most cat... |
In recent decades, the frequency and intensity of climate-related natural hazards have both increased.Extreme flooding and flood-related events are leading this trend, and the United Kingdom has been particularly affected by these phenomena.These events have resulted in severe social and economic costs all over the wor... | These disasters represent high costs and functional disruptions to societies and economies.To obtain an accurate assessment of total flooding costs, this paper introduces the flood footprint concept, as a novel accounting framework that measures the total economic impact that is directly and indirectly caused to the pr... |
sector groups.For example, Manufacturing is shown to be the most affected sector, with a share of indirect loss 60% higher than direct loss, and the total damages in this group account for 23% of the total flood footprint.The utilities sector suffers major direct damages, as infrastructure damages are allocated among t... | International headlines over the last few years have been dominated by extreme weather events, and floods have been amongst the most frequent and devastating.The consequent breakdown of the economic equilibrium exacerbates the losses of the initial physical damages and generates indirect costs that largely amplify the ... |
the following categories are also included: primary energy demand, volumetric water consumption and water footprint.PED has been quantified through GaBi.The WC accounts for blue and green water, based on data from the Water Footprint Network.However, only blue water is included in the WF, taking into account water stre... | The most significant life cycle stage for all types is the raw materials production, causing 41%–61% of the total impacts, with flour, sugar and palm oil being the key hotspots.These results can help guide manufacturers in mitigating the hotspots in the supply chain and consumers in selecting environmentally more susta... |
contrast to the per-kg impacts, the annual impacts are dominated by crackers, low fat/sugar biscuits and semi-sweet biscuits due to their high sales volumes.Crackers contribute 7%–17% to the total impacts, while low fat/sugar biscuits make up 10%–24% and semi-sweet biscuits 7%–16%.The chocolate-coated biscuits, despite... | Therefore, this paper sets out to evaluate the life cycle environmental sustainability of the following widely-consumed types of biscuit, both at the product and sectoral levels: crackers, low fat/sugar, semi-sweet, chocolate-coated and sandwich biscuits with chocolate or vanilla cream.The results obtained through life... |
State-of-the-art deep neural networks typically have tens of millions of parameters, which might not fit into the upper levels of the memory hierarchy, thus increasing the inference time and energy consumption significantly, and prohibiting their use on edge devices such as mobile phones.The compression of DNN models h... | We revisit the simple idea of pruning connections of DNNs through regularization achieving state-of-the-art results on multiple datasets with theoretic guarantees. |
Italy, which relies entirely on import for covering its domestic consumption .The analysis of the pulp and paper sub-sector clearly shows that any discussion over the issue of energy and carbon intensity of a country in relation to the efficiency of the technologies used in the economy should start from an analysis of ... | Within the context of the controversial use of the concept energy intensity to assess national energy performance, this paper proposes an innovative accounting framework: the energy end-use matrix.This tool integrates quantitative assessments of energy use of the various constituent compartments of socio-economic syste... |
for crude samples.Mg2+ ions have no effect on the assay in the final concentration range of 0.5–0.1 M and the salt concentrations of up to 3 M NaCl will not affect the assay negatively.3.Confocal microscopy preparation and imaging,For visible light and high numerical aperture objectives a pixel size of ∼0.1–0.2 μm is r... | Most molecular fingerprinting techniques, including denaturing gradient gel electrophoresis (DGGE) [1], comparative genomic hybridization (CGH) [2], real-time polymerase chain reaction (RT-PCR) [3], destroy community structure and/or cellular integrity, therefore lost the info.of the spatial locus and the in situ genom... |
adaptiveness of the model, i.e., how finely split the subgroups are, and the size of the subgroups, i.e., how robust and precise the prediction models are, must be found.In this case, optimization for this was not performed, but a good balance was achieved by the sheer number of samples and the design of the enzyme-raw... | In the presented study, Fourier-transform infrared (FTIR) spectroscopy is used to predict the average molecular weight of protein hydrolysates produced from protein-rich by-products from food industry using commercial enzymes.Enzymatic protein hydrolysis is a well-established method for production of protein-rich formu... |
km long lagoon defined by a reef running parallel to the beach.The reefs defining such lagoons are typically several hundred metres wide, but outside Xai-Xai it is only about 20 m wide, and very regularly shaped defining a straight line, see Fig. 1.The main opening of the reef is found in the east-northeastern end of t... | Alongshore flows strongly driven by tides and waves is studied in the context of a one-dimensional numerical model.Observations from field surveys performed in a semi-enclosed lagoon (1.7km×0.2km) outside Xai-Xai, Mozambique, are used to validate the model results.The model is able to capture most of the observed tempo... |
greater evidence compared to at least half of the other tracts examined, reducing the potential for these significant artefactual terminations.Within the current study, the meta-analyses used in the functional analyses were obtained using the automated meta-analysis software package Neurosynth, which is freely availabl... | Despite an upsurge of interest in connectional neuroanatomy, the terminations of the main fibre tracts in the human brain are yet to be mapped.This information is essential given that neurological, neuroanatomical and computational accounts expect neural functions to be strongly shaped by the pattern of white-matter co... |
using software iCODEhop .Entire specimen or an appendage was used for isolation of DNA.DNA was isolated using GenElute Mammalian Genomic DNA Miniprep Kit following the protocol for DNA isolation from tissues » Mammalian Tissue Preparation«.One specimen was fixed in formalin.Therefore for the successful amplification of... | The data presented here includes selection of 5 successfully amplified protein-coding markers for inferring phylogenetic relationships of the family of amphipod crustaceans Niphargidae.These markers have been efficiently amplified from niphargid samples for the first time and present the framework for robust phylogenet... |
sub-visible particles as endogenous components.As a part of a test package for investigational products, ESZ offers considerable advantages as a method for particle count and size distribution assessment.Considering the importance of BCG IT for clinical use such as intravesical immunotherapy in superficial bladder canc... | Bacille Calmette-Guerin, BCG, is a live attenuated bovine tubercle bacillus used for the treatment of non-muscle invasive bladder cancer.In this study, an Electrical Sensing Zone (ESZ) method was developed to measure the particle count and the size of BCG immunotherapeutic (BCG IT), or ImmuCyst® product using a Coulter... |
harvests of the same manufactured batches due to its enrichment through the purification process.HMWI percentages in drug substances measured by CE western were plotted against those for the cell harvest samples of the same batches measured by the same method in Fig. 4A.The data are fitted to linear regression, as show... | An effective control strategy is critical to ensure the safety, purity and potency of biopharmaceuticals.Appropriate analytical tools are needed to realize such goals by providing information on product quality at an early stage to help understanding and control of the manufacturing process.In this work, a fully automa... |
as described above, mice lacking functional PI3Kδ can show increased IgE-mediated eosinophilia and inflammation , but the extent to which this might be transferred to humans is unclear.The recent discovery of activating mutations in the p110δ subunit in a group of primary immune deficiency patients both illustrates the... | Abstract PI3Ks regulate several key events in the inflammatory response to damage and infection.There are four Class I PI3K isoforms (PI3Kα,β,γ,δ), three Class II PI3K isoforms (PI3KC2α, C2β, C2γ) and a single Class III PI3K.The four Class I isoforms synthesise the phospholipid 'PIP3'.PIP3 is a 'second messenger' used ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.