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values | query stringlengths 26 249 | positive stringlengths 20 1.8k | negatives listlengths 4 4 | query_id stringlengths 1 4 | positive_id stringlengths 4 9 | negative_ids listlengths 4 4 | task_type stringclasses 2
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|---|---|---|---|---|---|---|---|---|---|
86ef4b3968279ffb992c429a14086287 | mteb/scifact | Energy balance requires hypothalamic glutamate neurotransmission. | Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.. The importance of neuropeptides in the hypothalamus has been experimentally established. Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate ... | [
"The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.. BACKGROUND Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Syste... | 378 | 11886686 | [
"4700428",
"16398827",
"2481032",
"14782049"
] | scientific_claim_retrieval | scientific |
831287202563c6c2fcfa825e9b0ab7e3 | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross. Enhanced host protection against re-infection requires generation of memory T cells of sufficient quantity and functional quality. Unlike well-studied inbred mice, T cell responses of diverse size and quality are generated following in... | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | kvmjkknp | [
"9807pgmy",
"1kwb0v71",
"5zuij5i3",
"xmjzgqq7"
] | biomedical_literature_retrieval | scientific |
550766ca15af34d0c7a266242fa99a2d | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | A highly specific rapid antigen detection assay for on-site diagnosis of MERS | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | 7l8boeom | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
c813c64a6c8e9fb85daa2d6064c66eaf | mteb/trec-covid | is remdesivir an effective treatment for COVID-19 | Remdesivir, the antiviral hope against SARS-CoV-2/ Remdesivir, la esperanza antiviral frente al SARS-CoV-2. On December 31, 2019 a pneumonia outbreak caused by a new coronavirus (SARS-CoV-2) was detected in the city of Wuhan (China) Due to the high capacity of diffusion and human infection it has become a new zoonotic ... | [
"Antibacterial activity of iron oxide, iron nitride, and tobramycin conjugated nanoparticles against Pseudomonas aeruginosa biofilms. BACKGROUND: Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common infectious species ... | 30 | puc13jf1 | [
"ygf165x2",
"vlv8x8l8",
"y47fq64r",
"5c1rhmmm"
] | biomedical_literature_retrieval | scientific |
8af7a0f3267618e71fcd2935fd01684f | mteb/scifact | Treatment with the EC uptake inhibitor AM404 resulted in a dose-dependent decrease in the expression of immobility. | Functional role of high-affinity anandamide transport, as revealed by selective inhibition.. Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation is not completely understood, but it may occur by transport into ce... | [
"PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.. AMP-activated protein kinase (AMPK) is an energy-sensing enzyme whose activity is inhibited in settings of insulin resistance. Exposure to a high glucose concentration has recently been shown to incr... | 1325 | 40476126 | [
"23974474",
"10207180",
"45153864",
"15563864"
] | scientific_claim_retrieval | scientific |
26a6bdddddea94af1f77597f2bc65307 | mteb/trec-covid | what drugs have been active against SARS-CoV or SARS-CoV-2 in animal studies? | Remdesivir, the antiviral hope against SARS-CoV-2/ Remdesivir, la esperanza antiviral frente al SARS-CoV-2. On December 31, 2019 a pneumonia outbreak caused by a new coronavirus (SARS-CoV-2) was detected in the city of Wuhan (China) Due to the high capacity of diffusion and human infection it has become a new zoonotic ... | [
"Emerging Animal Coronaviruses: First SARS and Now MERS. The first major pandemic of the new millennium that arose from southern China in 2002 was of zoonotic origin from wild game animals, called severe acute respiratory syndrome [SARS]. The culprit was determined to be a coronavirus of animal origin [SARS-CoV]. T... | 5 | puc13jf1 | [
"3114rz8f",
"qilqtvzt",
"zrobpop6",
"isvkp4d1"
] | biomedical_literature_retrieval | scientific |
0dff6b198f40a001534e2ee916932b8a | mteb/scifact | Cell autonomous sex determination in somatic cells occurs in Galliformes. | Somatic sex identity is cell-autonomous in the chicken. In the mammalian model of sex determination, embryos are considered to be sexually indifferent until the transient action of a sex-determining gene initiates gonadal differentiation. Although this model is thought to apply to all vertebrates, this has yet to be es... | [
"Nanog safeguards pluripotency and mediates germline development. Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and developing germ cells. Deletion of Nanog causes early embryonic lethality, whereas constitutive expression enables autonomous self-renewal of embryonic stem cells. Nano... | 235 | 4388470 | [
"4423327",
"15803282",
"7426741",
"17844478"
] | scientific_claim_retrieval | scientific |
fd6972d98bf0cc9971176bad328da724 | mteb/scifact | The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling. | YOKO HONDA AND SHUJI HONDA 1. Longevity is regulated by the daf-2 gene network in Caenorhabditis elegans. Mutations in the daf-2 gene, which encodes a member of the insulin receptor family, confer the life extension (Age) phenotype and the constitutive dauer (a growth-arrested larval form specialized for dispersal) for... | [
"Influence of Steroid Hormone Signaling on Life Span Control by Caenorhabditis elegans Insulin-Like Signaling. Sterol-sensing nuclear receptors and insulin-like growth factor signaling play evolutionarily conserved roles in the control of aging. In the nematode Caenorhabditis elegans, bile acid-like steroid hormone... | 1219 | 14864285 | [
"14544564",
"13072113",
"1576955",
"29429111"
] | scientific_claim_retrieval | scientific |
5c5a2ff160fb76972eae22fef9572b7e | mteb/scifact | RUNX is not expressed in skin tissue. | Human epidermal stem cell function is regulated by circadian oscillations.. Human skin copes with harmful environmental factors that are circadian in nature, yet how circadian rhythms modulate the function of human epidermal stem cells is mostly unknown. Here we show that in human epidermal stem cells and their differe... | [
"Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.. This study evaluates the expression of the chemorepellent semaphorin III (D)/collapsin-1 (sema III) following lesions to the rat C... | 1008 | 2547636 | [
"33535447",
"19427410",
"11238951",
"34846352"
] | scientific_claim_retrieval | scientific |
050d99aeba8b061d29b9771a1df8988c | mteb/scifact | β1/Ketel is able to bind microtubules. | A Microtubule Interactome: Complexes with Roles in Cell Cycle and Mitosis. The microtubule (MT) cytoskeleton is required for many aspects of cell function, including the transport of intracellular materials, the maintenance of cell polarity, and the regulation of mitosis. These functions are coordinated by MT-associate... | [
"Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.. Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin alpha IIb beta 3 (... | 1407 | 8087082 | [
"21164071",
"45199834",
"2151983",
"9638032"
] | scientific_claim_retrieval | scientific |
2043f261ed291832b418a0f5b4cc1efe | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | T follicular regulatory cells infiltrate the human airways during the onset of acute respiratory distress syndrome and regulate the development of B regulatory cells. T follicular regulatory (Tfr) cell is a CXCR5(+)Foxp3(+) subset of T regulatory (Treg) cell with critical roles in regulating germinal center responses a... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 61ezrjuq | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
c30799e4dfed31fd533b1376f3f294cc | mteb/scifact | miRNAs regulate a unique suite of mRNAs to maintain homeostasis in cells. | microRNAs: A Safeguard against Turmoil?. Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during st... | [
"CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control.. MicroRNAs (miRNAs) are a recently identified class of epigenetic elements consisting of small noncoding RNAs that bind to the 3' untranslated region of mRNAs and down-regulate their translation... | 1394 | 2251426 | [
"23727313",
"10670430",
"12652963",
"13964633"
] | scientific_claim_retrieval | scientific |
62b3766333a6cc1cb211e418238f75a5 | mteb/scifact | Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events. | Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry.. BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit... | [
"Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.. Angiotensin converting enzyme (ACE) inhibitors are now one ... | 342 | 5884524 | [
"6157837",
"471921",
"308862",
"15648443"
] | scientific_claim_retrieval | scientific |
6df94fe81b739115b35bd7fcc2339dc7 | mteb/scifact | Binding of p53 to enhancer regions (p53BERs) regulates the activity of p53 transcription and cell cycle arrest through the production of p53-dependent eRNAs. | eRNAs are required for p53-dependent enhancer activity and gene transcription.. Binding within or nearby target genes involved in cell proliferation and survival enables the p53 tumor suppressor gene to regulate their transcription and cell-cycle progression. Using genome-wide chromatin-binding profiles, we describe bi... | [
"Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ. BACKGROUND Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer... | 177 | 9669099 | [
"3590806",
"38919140",
"23985464",
"21557055"
] | scientific_claim_retrieval | scientific |
12d57fe7fcf4ac8033a778c1c76b43ca | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions. Activation and regulation of the cascade systems of the blood (the complement system, the coagulation/contact activation/kallikrein system, and the fibrinolytic system) occurs via activation of zymogen molec... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | ieb5ec5j | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
6625e87cfb99f0db33b36312e23fee8b | mteb/scifact | 7-day-old adult Caenorhabditis elegans exhibit approximately 75% of the learning capacity seen in 1-day old adults. | Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age. Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and mem... | [
"Economic implications of nighttime attending intensivist coverage in a medical intensive care unit.. OBJECTIVE Our objective was to assess the cost implications of changing the intensive care unit staffing model from on-demand presence to mandatory 24-hr in-house critical care specialist presence. DESIGN A pre-pos... | 20 | 3202143 | [
"40905302",
"41340212",
"24273592",
"9254550"
] | scientific_claim_retrieval | scientific |
69f9f02ffbde4c55f416030fc3002f2e | mteb/scifact | Pyridostatin stabilizes the G - quadruplex in the telomeric region. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei.. Most eukaryotic telomeres contain a repeating motif with stretches of guanine residues that form a 3'-terminal overhang extending beyond the telomeric duplex region. The telomeric repeat of hypot... | 1000 | 16472469 | [
"25842866",
"1583134",
"3033830",
"19487477"
] | scientific_claim_retrieval | scientific |
495b2200ed5f880e705e4603081029fc | mteb/scifact | Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) reveal increased sensitivity to ionizing radiation (IR). | Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.. DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functi... | [
"Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.. Mammalian DNA polymerase mu (pol mu) is related to terminal deoxynucleotidyl transferase, but its biological role is not yet clear. We show here that after exposure of cells to ionizing radi... | 777 | 32275758 | [
"27635177",
"11569583",
"31293581",
"6536598"
] | scientific_claim_retrieval | scientific |
b1e01869420ce5bfb6c3b0a5df6d8bd3 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics. Studies using human genetics have identified more than 160 loci that affect the risk of developing inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). Several of these genes ... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 6xgy0cm3 | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
63336787373265bfb1648651b1da658c | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | Emergency Triage of Highly Infectious Diseases and Bioterrorism. Emergency medical services are a key element in health systems for the evaluation and treatment of patients exposed to highly infectious diseases or bioterrorism agents. Triage and early identification at any point of care can have a significant impact on... | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | fz48wydz | [
"jzlouns7",
"jc443w2a",
"9807pgmy",
"0smru5k2"
] | biomedical_literature_retrieval | scientific |
d6b451abd1676c9c1abb8a7c3ac7b1f3 | mteb/scifact | Upregulation of PD1 causes the upregulation of Satb1. | SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells. &NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that the chromatin organizer special AT‐rich sequence‐binding p... | [
"PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Leukemias and other cancers possess self-renewing stem cells that help to maintain the cancer. Cancer stem cell eradication is thought to be crucial for successful anticancer therapy. Using an acute myeloid leukemi... | 1350 | 5377642 | [
"8764879",
"21498497",
"23273454",
"3870062"
] | scientific_claim_retrieval | scientific |
d5b2183cc8e26c6eb63a9b6e9b13193c | mteb/scifact | During non-homologous end joining, the ligation step is not as tolerant of disrepairs and other distortions when joining 3' of strand breaks as compared to 5' strand breaks. | The fidelity of the ligation step determines how ends are resolved during Nonhomologous end joining. Nonhomologous end joining (NHEJ) can effectively resolve chromosome breaks despite diverse end structures; however, it is unclear how the steps employed for resolution are determined. We sought to address this question ... | [
"Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends.. Nonhomologous end joining (NHEJ) is essential for efficient repair of chromosome breaks. However, the NHEJ ligation step is often obstructed by break-associated nucleotide damage, including base loss (abasic ... | 357 | 18111172 | [
"20821402",
"12552297",
"41403996",
"20240998"
] | scientific_claim_retrieval | scientific |
5b11f9f89d38aa692a43dcd95c9dd706 | mteb/scifact | The appearance of brown-like or beige cells primarily occurs in visceral fat, not subcutaneous fat. | Tracking adipogenesis during white adipose tissue development, expansion and regeneration. White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HF... | [
"Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity.. Adipose tissue exerts important endocrine and metabolic functions in health and disease. Yet the bioenergetics of this tissue is not characterized in humans and possible regional differences are not elucidated... | 1193 | 20532591 | [
"39187170",
"23017040",
"42465769",
"32955023"
] | scientific_claim_retrieval | scientific |
2d3f7590a35bd04cb6bfcee209dacf58 | mteb/scifact | Piezo1 channels are sensors for cell migration in epithelial cells. | Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro. Trefoil factor family 1 (TFF1) is a member of the TFF-domain peptide family involved in epithelial restitution and cell motility. Recently, we screened Piezo1 as a candidate TFF1-binding protein. We aimed t... | [
"Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes. BACKGROUND Carbon nanotubes (CNT) hold great promise to create new and better products for commercial and biomedical applications, but their long-term adverse health effects ... | 951 | 21414718 | [
"16532419",
"6308416",
"3118719",
"26047921"
] | scientific_claim_retrieval | scientific |
2f5f84f0765791ed55e76f483c02f036 | mteb/scifact | Inhibiting HDAC6 increases survival of mice with ARID1A mutated tumors. | ARID1A-mutated ovarian cancers depend on HDAC6 activity. ARID1A, encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this gene... | [
"Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium. Bacterial pathogens produce complex carbohydrate capsules to protect against bactericidal immune molecules. Paradoxically, the pneumococcal capsule sensitizes the bacterium to antimicrobial peptides found on epithe... | 631 | 5468807 | [
"1234098",
"9737083",
"7165938",
"3173489"
] | scientific_claim_retrieval | scientific |
8122f2c950b7e172cb291d5767fe762f | mteb/trec-covid | what is the origin of COVID-19 | Emerging Animal Coronaviruses: First SARS and Now MERS. The first major pandemic of the new millennium that arose from southern China in 2002 was of zoonotic origin from wild game animals, called severe acute respiratory syndrome [SARS]. The culprit was determined to be a coronavirus of animal origin [SARS-CoV]. The di... | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | 3114rz8f | [
"o0syp1wb",
"hs2vni8z",
"35c6mak0",
"72s8wpla"
] | biomedical_literature_retrieval | scientific |
6e56e43042517ee69bd02231962b9f7a | mteb/scifact | Distant CREs are less conserved among species. | Enhancer Evolution across 20 Mammalian Species. The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian specie... | [
"Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression.. We have cloned cDNAs for Caenorhabditis elegans cyclins A1, B and B3. While cyclins A1 and B are most closely related to either A- or B-type cyclins of other species, cyclin... | 352 | 14658685 | [
"24864273",
"19238",
"40971746",
"12462961"
] | scientific_claim_retrieval | scientific |
596ec0901f42fcb10daa8074f43860b4 | mteb/scifact | Mice defective for deoxyribonucleic acid (DNA) polymerase m (polm) fail to reveal increased sensitivity to ionizing radiation (IR). | Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.. DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functi... | [
"The DNA polymerase λ is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells. DNA polymerase lambda (polλ) is a recently identified DNA polymerase whose cellular function remains elusive. Here we show, that polλ participates at the molecular level in a chromosomal context, ... | 776 | 32275758 | [
"12552297",
"3173489",
"18987782",
"27635177"
] | scientific_claim_retrieval | scientific |
842a7c9f6dd47c208e36fe3de65bbdff | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Virology. Molecular techniques have become indispensable in viral diagnostics. Current applications include: (1) The detection of (unknown) viral infections in clinical samples. (2) Quantitative monitoring of viral load. (3) Genotyping of viral strains. (4) Detection of mutations in the viral genome that are associated... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | iajblrff | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
971f99e0e88be43f7c3b8193f283b088 | mteb/scifact | Reducing H3k4me3 methylation induces mouse epiblast stem cells to naive pluripotency efficiently. | MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency.. The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it is unclear whether intrinsic epigenetic events can drive reprogramming to naive pluripotency or if distinct chromatin st... | [
"Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Pluripotent stem cells exist in naive and primed states, epitomized by mouse embryonic stem cells (ESCs) and the developmentally more advanced epiblast stem cells (EpiSCs; ref. ). In the naive state of ESCs, the genome has... | 1030 | 6441369 | [
"23418635",
"14923462",
"1630949",
"16375102"
] | scientific_claim_retrieval | scientific |
24dddd409be3eef3daefadad56a89ec7 | mteb/scifact | The combination of physical examinations with C-reactive protein values do not improve the accuracy of radiographic verified pneumonia predictions. | Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. OBJECTIVES To quantify the diagnostic accuracy of selected inflammatory markers in addition to symptoms and signs for predict... | [
"Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.. Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform ... | 1205 | 5558754 | [
"9675944",
"29564505",
"5270265",
"4910408"
] | scientific_claim_retrieval | scientific |
0d3543a931e9d139a120009a3b69f0b6 | mteb/scifact | Sympathetic nerve activity is reduced throughout normal pregnancy. | Sympathetic neural mechanisms in normal and hypertensive pregnancy in humans.. BACKGROUND Direct recordings from peripheral sympathetic nerves have shown an increased sympathetic drive in pregnancy-induced hypertension (PIH) and preeclampsia (PE). It is unknown whether sympathetic drive is altered in normal pregnancy, ... | [
"Antioxidant Defenses in the Rat Placenta in Late Gestation: Increased Labyrinthine Expression of Superoxide Dismutases, Glutathione Peroxidase 3, and Uncoupling Protein 21. Placental oxidative stress plays a key role in the pathophysiology of placenta-related disorders, most notably preeclampsia (PE) and intrauter... | 1120 | 5323845 | [
"25293721",
"39776978",
"12130067",
"9197786"
] | scientific_claim_retrieval | scientific |
9699e9b61a43f994979454c1b500c6ad | mteb/scifact | The latent infection of myeloid cells with human cytomegalovirus induces a number of changes in gene expression. | Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage.. Monocytes are primary targets for human CMV (HCMV) infection and are proposed to be responsible for hematogenous dissemination of the virus. Monocytes acquire different functional traits during polarizatio... | [
"Analysis of Epstein-Barr virus-regulated host gene expression changes through primary B-cell outgrowth reveals delayed kinetics of latent membrane protein 1-mediated NF-κB activation.. Epstein-Barr virus (EBV) is an oncogenic human herpesvirus that dramatically reorganizes host gene expression to immortalize prima... | 1224 | 34016987 | [
"23305884",
"20675284",
"26133404",
"37762357"
] | scientific_claim_retrieval | scientific |
ec84b8c5a2ebf7e821e9d7cd3ba13b28 | mteb/scifact | Vitamin D is an important factor in the relationship between calcium and parathyroid hormone. | Relationship between serum parathyroid hormone levels, vitamin D sufficiency, and calcium intake.. CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known. Serum 25-hydroxyvitamin D is the generally accepted indicator of vitami... | [
"Vitamin D: The \"sunshine\" vitamin.. Vitamin D insufficiency affects almost 50% of the population worldwide. An estimated 1 billion people worldwide, across all ethnicities and age groups, have a vitamin D deficiency (VDD). This pandemic of hypovitaminosis D can mainly be attributed to lifestyle (for example, red... | 1371 | 16256507 | [
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] | scientific_claim_retrieval | scientific |
91fd820adf1306bd37a98675c4784b58 | mteb/scifact | Ca2+ cycling is a UCP1-independent thermogenic mechanism. | UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear. Here we report a robust UCP1-independent ... | [
"Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders. Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte... | 222 | 19205437 | [
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"29691654",
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] | scientific_claim_retrieval | scientific |
29ac47b1d83ceaf34900b57149df1817 | mteb/scifact | Neutrophils produce IL-1β in response to large particles. | Reactive Oxygen Species Localization Programs Inflammation to Clear Microbes of Different Size. How the number of immune cells recruited to sites of infection is determined and adjusted to differences in the cellular stoichiometry between host and pathogen is unknown. Here, we have uncovered a role for reactive oxygen ... | [
"Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus.. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and the development of immune complexes. Genomic approaches have shown that h... | 846 | 22696649 | [
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] | scientific_claim_retrieval | scientific |
84260a0cfe56da045f074d0d64b515de | mteb/scifact | The risk of breast cancer among parous women decreases with placental weight of pregnancies. | Pregnancy characteristics and maternal risk of breast cancer.. CONTEXT During pregnancy, serum levels of estrogen, progesterone, and other hormones are markedly higher than during other periods of life. Pregnancy hormones primarily are produced in the placenta, and signs of placental impairment may serve as indirect ma... | [
"Breast cancer and obesity: an update.. Obesity has a complicated relationship to both breast cancer risk and the clinical behavior of the established disease. In postmenopausal women, particularly the elderly, various measures of obesity have been positively associated with risk. However, before menopause increase... | 1265 | 37480103 | [
"25973484",
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] | scientific_claim_retrieval | scientific |
c6edcce6570539cf0d5debc55c738c30 | mteb/scifact | Suboptimal nutrition is a leading cause of premature death | Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. BACKGROUND The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides a... | [
"Pharmacological interventions for smoking cessation: an overview and network meta-analysis.. BACKGROUND Smoking is the leading preventable cause of illness and premature death worldwide. Some medications have been proven to help people to quit, with three licensed for this purpose in Europe and the USA: nicotine r... | 1109 | 13770184 | [
"5114940",
"32328114",
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] | scientific_claim_retrieval | scientific |
3e957dd044d1bb0e820036bc59d450e8 | mteb/scifact | PRC1-bound plasmids sediment at a slower rate in unbound plasmids than in sucrose gradients. | Polycomb Proteins Remain Bound to Chromatin and DNA during DNA Replication In Vitro. The transcriptional status of a gene can be maintained through multiple rounds of cell division during development. This epigenetic effect is believed to reflect heritable changes in chromatin folding and histone modifications or varia... | [
"Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in ... | 916 | 18037805 | [
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"1631583",
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] | scientific_claim_retrieval | scientific |
05a996eabbf2cc272f639cb85cfb4d7f | mteb/scifact | Drosophila supracellular actomyosin structures are found at boundaries in wing imaginal discs. | Increased Cell Bond Tension Governs Cell Sorting at the Drosophila Anteroposterior Compartment Boundary. Subdividing proliferating tissues into compartments is an evolutionarily conserved strategy of animal development [1-6]. Signals across boundaries between compartments can result in local expression of secreted prot... | [
"An actomyosin-based barrier inhibits cell mixing at compartmental boundaries in Drosophila embryos. Partitioning tissues into compartments that do not intermix is essential for the correct morphogenesis of animal embryos and organs. Several hypotheses have been proposed to explain compartmental cell sorting, mainl... | 355 | 12800122 | [
"13936152",
"16280642",
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] | scientific_claim_retrieval | scientific |
46209b89876fbc009f49fadd30b03b25 | mteb/scifact | Over half of the gabonese children with Schimmelpenning-Feuerstein-Mims syndrome (SFM) had a plasma lactate of more than 5mmol/L. | Assessment of Volume Depletion in Children with Malaria. Background The degree of volume depletion in severe malaria is currently unknown, although knowledge of fluid compartment volumes can guide therapy. To assist management of severely ill children, and to test the hypothesis that volume changes in fluid compartment... | [
"The Diabetes Prevention Program: baseline characteristics of the randomized cohort. The Diabetes Prevention Program Research Group.. OBJECTIVE The Diabetes Prevention Program (DPP) is a 27-center randomized clinical trial designed to evaluate the safety and efficacy of interventions that may delay or prevent devel... | 895 | 18750453 | [
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] | scientific_claim_retrieval | scientific |
ae939e20122a80b4db936081ab4635b5 | mteb/scifact | Consumption of whole fruits increases the risk of type 2 diabetes. | Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies. OBJECTIVE To determine whether individual fruits are differentially associated with risk of type 2 diabetes. DESIGN Prospective longitudinal cohort study. SETTING Health professionals in the United States. PARTICI... | [
"Averting Obesity and Type 2 Diabetes in India through Sugar-Sweetened Beverage Taxation: An Economic-Epidemiologic Modeling Study. BACKGROUND Taxing sugar-sweetened beverages (SSBs) has been proposed in high-income countries to reduce obesity and type 2 diabetes. We sought to estimate the potential health effects ... | 283 | 1974176 | [
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] | scientific_claim_retrieval | scientific |
cc7a71b66468c08cc76b087f1f6116fa | mteb/scifact | siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We d... | [
"A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy.. Epidermal growth factor receptor (EGFR) and HER3 each form heterodimers with HER2 and have independently been implicated as key coreceptors that drive HER2-amplified breast cancer. Some studies suggest a dominant role for ... | 1404 | 33370 | [
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] | scientific_claim_retrieval | scientific |
b4ea8e6f23b3fe0f4a058e0571114066 | mteb/scifact | Osteoparthritis (OA) is characterized by degeneration of articular cartilage, joint edge, and subchondral bone hyperplasia. | Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial.. CONTEXT Chronic low back pain (LBP) with degenerative lumbar osteoarthritis (OA) is widespread in the adult population. Although glucosamine is increasingly use... | [
"Cellular and histopathological changes in the infrapatellar fat pad in the monoiodoacetate model of osteoarthritis pain.. OBJECTIVE The infrapatellar fat pad (IPFP) has been identified as a source of anterior knee pain. Fibrosis and marked inflammatory infiltrate in the IPFP of patients with arthritis of the knee ... | 894 | 14724693 | [
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] | scientific_claim_retrieval | scientific |
74ce49aaf005c2d6d0267b01b06864a9 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Prevention of respiratory outbreaks in the rehabilitation setting. BACKGROUND: Respiratory viral (RV) outbreaks in rehabilitation facilities can jeopardise patient safety, interfere with patient rehabilitation goals and cause unit closures that impede patient flow in referring facilities. PROBLEM: Despite education abo... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | 25dcnext | [
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] | biomedical_literature_retrieval | scientific |
7e7a7ff4240d7f3157bff9b7584d4d1e | mteb/scifact | Human embryonic stem cells give rise to cell types from all three embryonic germ layers. | Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst.. Embryonic stem cells have the ability to remain undifferentiated and proliferate indefinitely in vitro while maintaining the potential to differentiate into derivatives of all three embryonic germ layers. These cells ha... | [
"Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell diffe... | 529 | 36651210 | [
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] | scientific_claim_retrieval | scientific |
0870891661dd6886e08151ab8ffa8d6c | mteb/scifact | Increased microtubule acetylation worsens interference of axonal transport caused by LRRK2 Roc-COR domain mutations. | Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease. LRRK2 is a multifunctional protein affecting many cellular processes and has been describe... | [
"ESCRT-III recognition by VPS4 ATPases. The ESCRT (endosomal sorting complex required for transport) pathway is required for terminal membrane fission events in several important biological processes, including endosomal intraluminal vesicle formation, HIV budding and cytokinesis. VPS4 ATPases perform a key functio... | 615 | 9638032 | [
"4429388",
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] | scientific_claim_retrieval | scientific |
1724b28bd803aa8964ad09ca2684aad5 | mteb/scifact | Taking anti-depresents is associated with a decrease in the Aβ level in the brain of experimental animals. | An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice. Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimer’s disease (AD). We show that in an aged transgenic AD mouse model (APP/PS1 plaque-bearing mice), the antidepressant cital... | [
"Cannabinoids in Clinical Practice. Cannabis has a potential for clinical use often obscured by unreliable and purely anecdotal reports. The most important natural cannabinoid is the psychoactive tetrahydrocannabinol (Δ9-THC); others include cannabidiol (CBD) and cannabigerol (CBG). Not all the observed effects can... | 1142 | 5260382 | [
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"1889358"
] | scientific_claim_retrieval | scientific |
750542120d40ab2ee1d51d1549bcc018 | mteb/scifact | Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates. | Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns. RNA processing is carried out in close proximity to the site of transcription, suggesting a regulatory link between transcription and pre-mRNA splicing. Using an in vitro transcription/splicing assay, we demonstrate that an ... | [
"Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity.. Adipose tissue exerts important endocrine and metabolic functions in health and disease. Yet the bioenergetics of this tissue is not characterized in humans and possible regional differences are not elucidated... | 964 | 4162857 | [
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] | scientific_claim_retrieval | scientific |
d65998f87f6e446b450a3c93663e2c1c | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Complications Among Adults Hospitalized With Influenza: A Comparison of Seasonal Influenza and the 2009 H1N1 Pandemic. Background. Persons with influenza can develop complications that result in hospitalization and death. These are most commonly respiratory related, but cardiovascular or neurologic complications or exa... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | mu7pvei0 | [
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4d14677e99a5142c6110ce79f1409834 | mteb/scifact | Cellular clocks are not predictive of mitosis timing in NIH 3T3 cells. | Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.. Daily synchronous rhythms of cell division at the tissue or organism level are observed in many species and suggest that the circadian clock and cell cycle oscillators are coupled. For mammals, despite known mechanistic i... | [
"Circadian Clocks in Human Red Blood Cells. Circadian (∼24 hour) clocks are fundamentally important for coordinated physiology in organisms as diverse as cyanobacteria and humans. All current models of the molecular circadian clockwork in eukaryotic cells are based on transcription-translation feedback loops. Non-t... | 242 | 10608822 | [
"4385779",
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] | scientific_claim_retrieval | scientific |
5729106d60ca8f4ab92332c085955039 | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Rapid multiserotype detection of human rhinoviruses on optically coated silicon surfaces. Background: More than 100 immunologically distinct serotypes of human rhinoviruses (HRV) have been discovered, making detection of surface exposed capsid antigens impractical. However, the non-structural protein 3C protease (3Cpro... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | smpfp34k | [
"6324190r",
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] | biomedical_literature_retrieval | scientific |
7327a97a78b5d243561fa54e568bff08 | mteb/scifact | BRCA 1 mutation carriers' risk of breast and ovarian cancer depends on where the mutation is located. | Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.. IMPORTANCE Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. OBJECTIVE To identify mutation-specific cancer risks for carriers of BRCA1/2. DESIGN... | [
"Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer.. PURPOSE Mutations in the BRCA1 and BRCA2 genes confer greater risk of developing breast cancer. We determined whether tumor pathologic features and clinical features differ in patients with and without BRCA mut... | 159 | 9394119 | [
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"24144677",
"4414547"
] | scientific_claim_retrieval | scientific |
bac9114f7988cd71a8d34589428e0f92 | mteb/scifact | Patients with common epithelial cancers are less likely to have an emergency event as their first hospital admission if they live in resource-deprived areas. | Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics. OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by soci... | [
"Dose-response study on thyrotoxic patients undergoing positron emission tomography and radioiodine therapy. With the acknowledged problems associated with assessment of functioning thyroid mass and hence radiation dose, our policy had been to give 75 MBq iodine-131 at 6-monthly intervals to patients with Graves' d... | 927 | 16390264 | [
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"6415816"
] | scientific_claim_retrieval | scientific |
12873e49f545313ba263aaaadf220c29 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Infection prevention and control in paediatric office settings. Transmission of infection in the paediatric office is an issue of increasing concern. This document discusses routes of transmission of infection and the principles of current infection control measures. Prevention includes appropriate office design and ad... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | fojzhlzx | [
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4eeea487fe47f766de74bdd9464e1c77 | mteb/scifact | Addition of BMP4, activin A, CHIR99021, and SU504 to reprogramming fibroblasts generates, expands and maintains cardiovascular progenitor cells (CPCs) | Expandable Cardiovascular Progenitor Cells Reprogrammed from Fibroblasts.. Stem cell-based approaches to cardiac regeneration are increasingly viable strategies for treating heart failure. Generating abundant and functional autologous cells for transplantation in such a setting, however, remains a significant challenge... | [
"Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell diffe... | 82 | 3619372 | [
"4427392",
"43385013",
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] | scientific_claim_retrieval | scientific |
6e4b1ff149e4a221cd46fe5f9241f060 | mteb/scifact | Sympathetic nerve activity is elevated throughout normal pregnancy. | Regulation of sympathetic nerve activity during the cold pressor test in normotensive pregnant and nonpregnant women.. Baseline neurovascular transduction is reduced in normotensive pregnancy; however, little is known about changes to neurovascular transduction during periods of heightened sympathetic activation. We te... | [
"Sympathetic activation during early pregnancy in humans.. Sympathetic activity has been reported to increase in normotensive pregnant women, and to be even greater in women with gestational hypertension and preeclampsia at term. Whether sympathetic overactivity develops early during pregnancy, remaining high throu... | 1119 | 13907928 | [
"26710772",
"20418809",
"42441846",
"4409524"
] | scientific_claim_retrieval | scientific |
de0f0bd3af39a73032ea406862f49fe3 | mteb/scifact | Differentiated E2f-1, -2, -3 TKO cells in the intestine do not exhibit apoptosis. | E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells. In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from entering S phase by binding and sequestering E2f activators (E2f1, E2f2 and E2f3), which are invariably por... | [
"A three-dimensional human neural cell culture model of Alzheimer’s disease. Alzheimer’s disease is the most common form of dementia, characterized by two pathological hallmarks: amyloid-β plaques and neurofibrillary tangles. The amyloid hypothesis of Alzheimer’s disease posits that the excessive accumulation of am... | 345 | 4394817 | [
"4459491",
"7688110",
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] | scientific_claim_retrieval | scientific |
fd9f129d11993bedf829b252d9b91778 | mteb/scifact | Rapid phosphotransfer rates are correlated with histidine kinase regulator specificity. | Using Structural Information to Change the Phosphotransfer Specificity of a Two-Component Chemotaxis Signalling Complex. Two-component signal transduction pathways comprising histidine protein kinases (HPKs) and their response regulators (RRs) are widely used to control bacterial responses to environmental challenges. ... | [
"Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma. Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown. Epidermal growth factor receptor (EGFR) activation by amplification or mutation i... | 1018 | 11603066 | [
"12685434",
"5321708",
"15113221",
"9612317"
] | scientific_claim_retrieval | scientific |
c7d52f3ba9a13300df88182fbd378be8 | mteb/scifact | H4 G94P proteins inhibit chromatin assembly, which decreases free histones. | Histone levels are regulated by phosphorylation and ubiquitylation dependent proteolysis. Histone levels are tightly regulated to prevent harmful effects such as genomic instability and hypersensitivity to DNA-damaging agents due to the accumulation of these highly basic proteins when DNA replication slows down or stop... | [
"Structure of Actin-related protein 8 and its contribution to nucleosome binding. Nuclear actin-related proteins (Arps) are subunits of several chromatin remodelers, but their molecular functions within these complexes are unclear. We report the crystal structure of the INO80 complex subunit Arp8 in its ATP-bound f... | 486 | 14637235 | [
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"175735",
"8331432",
"14338915"
] | scientific_claim_retrieval | scientific |
e5541fcad35443635625e23c860b377d | mteb/scifact | Pyridostatin prevents double-strand breaks accumulation. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"The ACF1 complex is required for DNA double-strand break repair in human cells.. DNA double-strand breaks (DSBs) are repaired via nonhomologous end-joining (NHEJ) or homologous recombination (HR), but cellular repair processes remain elusive. We show here that the ATP-dependent chromatin-remodeling factors, ACF1 a... | 998 | 16472469 | [
"20420780",
"14178995",
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] | scientific_claim_retrieval | scientific |
2f5216fd2fda74415f0c505182abf1ba | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Next-generation influenza vaccines: opportunities and challenges. Seasonal influenza vaccines lack efficacy against drifted or pandemic influenza strains. Developing improved vaccines that elicit broader immunity remains a public health priority. Immune responses to current vaccines focus on the haemagglutinin head dom... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | 8qv8af7k | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
324524b4e6ce3360ed92082c9b422cff | mteb/scifact | Angiotensin converting enzyme inhibitors are associated with decreased risk for functional renal insufficiency. | Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.. Angiotensin converting enzyme (ACE) inhibitors are now one of th... | [
"Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.. BACKGROUND Angiotensin receptor blockers (ARB) and angiotensin converting enzyme (ACE) inhibitors are known to reduce proteinuria. Their combination ... | 112 | 6157837 | [
"25816994",
"14584755",
"1759213",
"32463364"
] | scientific_claim_retrieval | scientific |
015d21f232aec1036e1be025357da26a | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China. A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandemic to the world population. Current efforts are focused on containment and quarantine of infected individual... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | 2jq626ye | [
"mx4t6s6n",
"r8fmq65g",
"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
d9ef8a12b498b8d36b28d281e0f84ecb | mteb/scifact | Mice that lack Interferon-γ or its receptor are highly susceptible to experimental autoimmune myocarditis. | Lethal autoimmune myocarditis in interferon-gamma receptor-deficient mice: enhanced disease severity by impaired inducible nitric oxide synthase induction.. BACKGROUND Interferon-gamma (IFN-gamma) is an essential cytokine in the regulation of inflammatory responses in autoimmune diseases. Little is known about its role... | [
"Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.. V domain-containing Ig suppressor of T-cell activation (VISTA) is a negative checkpoint regulator that suppresses T cell-mediated immune responses. Previous studies using a VI... | 780 | 24338780 | [
"23912923",
"17223891",
"17967608",
"5811042"
] | scientific_claim_retrieval | scientific |
899e11cd2abc6ccf14e9d1dc0b25ede6 | mteb/scifact | Mice lacking Sirt1 in Sf1-expressing neurons have increased susceptibility to diet-induced obesity and insulin resistance. | SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance.. Chronic feeding on high-calorie diets causes obesity and type 2 diabetes mellitus (T2DM), illnesses that affect hundreds of millions. Thus, understanding the pathways protecting against diet-induced metabolic imbalance is of paramount medical impor... | [
"Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB.. We show that NF-kappaB and transcriptional targets are activated in liver by obesity and high-fat diet (HFD). We have matched this state of chronic, subacute 'inflammation' by low-level activation of NF-kappaB in th... | 779 | 13001323 | [
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] | scientific_claim_retrieval | scientific |
1290eff28a9ef3de2085c8eeb3be7896 | mteb/trec-covid | what are the transmission routes of coronavirus? | Airborne Precautions and Personal Protective Equipment: The Powered Air-Purifying Respirator-Only Approach. Airborne isolation of patients and use of respirators are a foundational strategy to prevent transmission of pathogens like tuberculosis and novel respiratory viruses via airborne route in healthcare settings. He... | [
"Vaccination Method Affects Immune Response and Bacterial Growth but Not Protection in the Salmonella Typhimurium Animal Model of Typhoid. Understanding immune responses elicited by vaccines, together with immune responses required for protection, is fundamental to designing effective vaccines and immunisation prog... | 13 | 3sdmqj4e | [
"jrnm113q",
"nufzukak",
"wuu713l2",
"0c56x9f5"
] | biomedical_literature_retrieval | scientific |
a48c325f4746b5b9ace262b0d8e05c43 | mteb/scifact | Folate and vitamin B12 levels influence the association between homocysteine and preeclampsia. | Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. BACKGROUND The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A previou... | [
"Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population.. INTRODUCTION Elevated plasma total homocysteine is a major risk for coronary artery disease (CAD). Methyltetrahydrofolate reductase (MTHFR) is a main... | 423 | 8595678 | [
"42441846",
"37424881",
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"38551172"
] | scientific_claim_retrieval | scientific |
c4085aef077c38124ec35865369823c3 | mteb/scifact | Birth-weight is negatively associated with breast cancer. | Intrauterine environments and breast cancer risk: meta-analysis and systematic review. INTRODUCTION Various perinatal factors, including birth weight, birth order, maternal age, gestational age, twin status, and parental smoking, have been postulated to affect breast cancer risk in daughters by altering the hormonal en... | [
"Birth weight and mammographic density among postmenopausal women in Sweden.. Birth weight is a significant predictor of breast cancer risk in adult life and mammary gland mass could be an intermediate stage in this long process. We have studied the association of birth size measurements with mammographic density, ... | 178 | 17450673 | [
"5487448",
"16701509",
"13765757",
"25973484"
] | scientific_claim_retrieval | scientific |
03cb32a8f81ee98c330a5566a24fd412 | mteb/scifact | Pre-mRNAs associated with spliceosomal components are more stable than unassociated splicing substrates. | Analyzing mechanisms of alternative pre-mRNA splicing using in vitro splicing assays.. The development of in vitro assays to analyze pre-mRNA splicing resulted in the discovery of many fundamental features characterizing splicing signals and the machinery that completes this process. Because in vitro assays can be mani... | [
"Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity.. Adipose tissue exerts important endocrine and metabolic functions in health and disease. Yet the bioenergetics of this tissue is not characterized in humans and possible regional differences are not elucidated... | 964 | 29828242 | [
"39187170",
"10423989",
"15889329",
"15113221"
] | scientific_claim_retrieval | scientific |
877fe7af7d72d9ffa7290bfff1f55f61 | mteb/scifact | De novo assembly of sequence data has shorter contigs than unassembled sequence data. | A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4.. IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditional culture-based diagnosis can be difficult, particularly i... | [
"Effects of GC Bias in Next-Generation-Sequencing Data on De Novo Genome Assembly. Next-generation-sequencing (NGS) has revolutionized the field of genome assembly because of its much higher data throughput and much lower cost compared with traditional Sanger sequencing. However, NGS poses new computational challen... | 313 | 6173523 | [
"14464451",
"17447653",
"15966318",
"14915566"
] | scientific_claim_retrieval | scientific |
6e0aa533d5549f49a67e6daef2827fd8 | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | The efficiency of surgical masks of varying design and composition. Five different types of surgical mask of varying design and composition of natural and synthetic fibres were tested for their efficiency in vivo by means of a special test chamber. Contaminated particles escaping through or around the mask during speec... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | hq0owf31 | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
172bf23acf3de7764cbdb016e1ecd15f | mteb/scifact | The M2-phenotype in brown adipose tissue macrophages increases brown adipose tissue thermogenic activity. | Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. All homeotherms use thermogenesis to maintain their core body temperature, ensuring that cellular functions and physiological processes can continue in cold environments. In the prevailing model of thermogenesis, when the hypo... | [
"Triglyceride depletion of brown adipose tissue enables analysis of mitochondrial respiratory function in permeabilized biopsies.. The research on mitochondrial functions in adipocytes has increasingly evidenced that mitochondria plays an important role in the onset and/or progression of obesity and related patholo... | 1169 | 4319174 | [
"40232172",
"14865329",
"29691654",
"11428884"
] | scientific_claim_retrieval | scientific |
00d5cbc04e8d10f93dd548b6f0161cb4 | mteb/scifact | siRNA knockdown of A20 slows tumor progression in an in vivo murine xenograft model. | A20 is overexpressed in glioma cells and may serve as a potential therapeutic target.. OBJECTIVE A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells. This study investigates A20 expression in human glioma tissues and four glioma cell lines, and its e... | [
"A central role for HER3 in HER2-amplified breast cancer: implications for targeted therapy.. Epidermal growth factor receptor (EGFR) and HER3 each form heterodimers with HER2 and have independently been implicated as key coreceptors that drive HER2-amplified breast cancer. Some studies suggest a dominant role for ... | 1404 | 38355793 | [
"6550579",
"19358586",
"12489130",
"3545805"
] | scientific_claim_retrieval | scientific |
abe7fff7da305bf2ec656cc480dd1038 | mteb/scifact | Venules have less significant tunica adventitia than arterioles. | Scaffold-based three-dimensional human fibroblast culture provides a structural matrix that supports angiogenesis in infarcted heart tissue.. BACKGROUND We have developed techniques to implant angiogenic patches onto the epicardium over regions of infarcted cardiac tissue to stimulate revascularization of the damaged t... | [
"Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events.. OBJECTIVE To assess whether sex differences exist in the angiographic severity, management and outcomes of acute coronary syndromes (ACS). METHODS The stu... | 1364 | 8290953 | [
"29253460",
"14717500",
"24594624",
"409280"
] | scientific_claim_retrieval | scientific |
3b33b52aca8be5c1be9765160fcf0e5b | mteb/scifact | Human embryonic stem cells have the capacity to give rise to differentiated progeny representative of all three embryonic germ layers. | Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst.. Somatic cell nuclear transfer (SCNT) technology has recently been used to generate animals with a common genetic composition. In this study, we report the derivation of a pluripotent embryonic stem (ES) cell line (SCNT-hES-1) fr... | [
"TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.. Human embryonic stem cells (hESCs) self-renew indefinitely and give rise to derivatives of all three primary germ layers, yet little is known about the signaling cascades that govern their pluripotent c... | 531 | 10546779 | [
"26374799",
"4427392",
"19770974",
"36398420"
] | scientific_claim_retrieval | scientific |
f0e7f28429b0d10b64afd30893d84d2d | mteb/scifact | Progerin induces premature aging in stem cells. | Human iPSC-based modeling of late-onset disease via progerin-induced aging.. Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for inducing... | [
"Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major architectural elements of the mammalian ce... | 979 | 11659421 | [
"22544171",
"14581009",
"9997636",
"28071965"
] | scientific_claim_retrieval | scientific |
935defdad3dfc5c366ce2b3e1b0f4e33 | mteb/scifact | Increase of p62 in prostate tumor stroma results in defective autophagy. | p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.. Hepatic stellate cells (HSCs) play critical roles in liver fibrosis and hepatocellular carcinoma (HCC). Vitamin D receptor (VDR) activation in HSCs inhibits liver inflammation and fibrosis. We found that p6... | [
"Defective regulation of adipose tissue autophagy in obesity. Objectives: Autophagy is a highly regulated process that has an important role in the control of a wide range of cellular functions, such as organelle recycling, nutrient availability and tissue differentiation. A recent study has shown an increased auto... | 602 | 3701541 | [
"10463997",
"24349992",
"25576204",
"26735905"
] | scientific_claim_retrieval | scientific |
60484fba972365285993268aa1ab0bab | mteb/scifact | TNFAIP3 is a glioblastoma tumor enhancer. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We d... | [
"Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.. Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G3... | 1134 | 33370 | [
"41293601",
"41340212",
"9669099",
"57783564"
] | scientific_claim_retrieval | scientific |
4d63e7bca41bd2b4079bafbde9cdaae3 | mteb/scifact | Nonsteroidal antinflammatory drugs show potential anticancer indications. | Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants.. IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE To identify common genetic markers that may confer differential benefit from... | [
"Peroxisome proliferator-activated receptor alpha activation decreases metastatic potential of melanoma cells in vitro via down-regulation of Akt.. PURPOSE Peroxisome proliferator-activated receptors (PPAR) regulate lipid and glucose metabolism but their anticancer properties have been recently studied as well. We ... | 857 | 43334921 | [
"25328476",
"11484808",
"5586392",
"29807737"
] | scientific_claim_retrieval | scientific |
a941779fbb2e6cd43708a85222df9525 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Angiotensin-converting enzyme 2 (ACE2) is critically involved in cardiovascular physiology and pathology, and is currently clinically evaluated to treat acute lung failure. Here we show that the B38-CAP, a carboxypeptid... | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | aj7ybyl0 | [
"mx4t6s6n",
"r8fmq65g",
"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
9b61fed23ea1017933741b03a49f5d37 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | The Establishment and Validation of the Human U937 Cell Line as a Cellular Model to Screen Immunomodulatory Agents Regulating Cytokine Release Induced by Influenza Virus Infection. Severe influenza infections are often associated with the excessive induction of pro-inflammatory cytokines, which is also referred to as “... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | clqfq8hw | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
ee157b748adad5149cfa089a63b25c5a | mteb/scifact | Lmna knock-in models are appropriate for testing therapeutic approaches against Hutchinson-Gilford progeria syndrome (HGPS). | Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major architectural elements of the mammalian cell nu... | [
"Hutchinson-Gilford progeria syndrome: review of the phenotype. Hutchinson-Gilford progeria syndrome (HGPS) is a rare but well known entity characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble... | 698 | 22544171 | [
"15692098",
"14178995",
"24019260",
"7239105"
] | scientific_claim_retrieval | scientific |
ae2d0867763e87749481878fe67bf996 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Immune response in Dobrava-Belgrade virus infections. Dobrava-Belgrade virus (DOBV) is a hantavirus that causes a disease in humans known as hemorrhagic fever with renal syndrome. Hallmarks of hantaviral infections are increased vascular permeability due to dysregulation of the endothelial cell barrier and acute thromb... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | k9yjwnmt | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
cb6289797797a3af03fcf630d5b108b0 | mteb/scifact | Clathrin stabilizes the spindle fiber apparatus during mitosis. | Clathrin is required for the function of the mitotic spindle. Clathrin has an established function in the generation of vesicles that transfer membrane and proteins around the cell. The formation of clathrin-coated vesicles occurs continuously in non-dividing cells, but is shut down during mitosis, when clathrin concen... | [
"PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.. The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase bridges (UFBs) in mitosis alongside a complex of DNA repair proteins, including the Bloom's syndrome protein (BLM). However, very little is known ab... | 265 | 2033917 | [
"13953762",
"14205246",
"38127792",
"7666498"
] | scientific_claim_retrieval | scientific |
daeb71ecb44879688144b44de5c48843 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Seasonal and pandemic influenza: 100 years of progress, still much to learn. Influenza viruses are highly transmissible, both within and between host species. The severity of the disease they cause is highly variable, from the mild and inapparent through to the devastating and fatal. The unpredictability of epidemic an... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | j54k5x8m | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
96efeffb8b915f28d7439bc766d8ce1c | mteb/scifact | In transgenic mice harboring green florescent protein under the control of the Sox2 promoter, more than 50 percent of the cells with green florescent colocalize with cell proliferation markers. | Cell Stem Cell Article In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Capacities of Sox2 + Neural Stem Cells in the Adult Hippocampus. To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgenic mice. Sox2-GFP cells in the subgranular zone (SGZ) expres... | [
"Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.. CD4 T cells are important in the protective immune response against tuberculosis. Two mouse models deficient in CD4 T cells were used to examine the mechanism by which these cells participate in protec... | 588 | 16999023 | [
"21878751",
"15563864",
"13944805",
"23985464"
] | scientific_claim_retrieval | scientific |
72222a04a3b69542f93545d3aec96e6b | mteb/scifact | Genetic deletion of JAM-A increases gut permeability. | Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.. Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colit... | [
"Sir2-Independent Life Span Extension by Calorie Restriction in Yeast. Calorie restriction slows aging and increases life span in many organisms. In yeast, a mechanistic explanation has been proposed whereby calorie restriction slows aging by activating Sir2. Here we report the identification of a Sir2-independent ... | 461 | 40096222 | [
"7185591",
"5409325",
"36066871",
"14362678"
] | scientific_claim_retrieval | scientific |
1accf1e91a64cfa1516cebd7b817a6d7 | mteb/scifact | The DESMOND program demonstrates no significant impact on biochemical outcomes. | Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: three year follow-up of a cluster randomised controlled trial in primary care. OBJECTIVE To measure whether the benefits of a single education and self management structured programme ... | [
"Transtheoretical model-based multiple behavior intervention for weight management: effectiveness on a population basis.. BACKGROUND The increasing prevalence of overweight and obesity underscores the need for evidence-based, easily disseminable interventions for weight management that can be delivered on a populat... | 1157 | 12584053 | [
"6841927",
"39264456",
"34139429",
"36033696"
] | scientific_claim_retrieval | scientific |
32dfa076cb747cd22dd25d98cce245c2 | mteb/scifact | The PPR MDA5 has twenty N-terminal CARD domains. | Immune signaling by RIG-I-like receptors.. The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 play a major role in pathogen sensing of RNA virus infection to initiate and modulate antiviral immunity. The RLRs detect viral RNA ligands or processed self RNA in the cytoplasm to trigger innate immunity and inflammation ... | [
"Purification and structural characterization of bovine cathelicidins, precursors of antimicrobial peptides.. Cathelicidins are a novel family of antimicrobial peptide precursors from mammalian myeloid cells. They are characterized by a conserved N-terminal region while the C-terminal antimicrobial domain can vary ... | 1174 | 31272411 | [
"22191759",
"42314147",
"15419873",
"7751726"
] | scientific_claim_retrieval | scientific |
7fe07036b81671d79d82a7d5dbfe4106 | mteb/trec-covid | are patients taking Angiotensin-converting enzyme inhibitors (ACE) at increased risk for COVID-19? | Unravelling SARS lethality | [
"From gene to protein—experimental and clinical studies of ACE2 in blood pressure control and arterial hypertension. Hypertension is a major risk factor for stroke, coronary events, heart and renal failure, and the renin-angiotensin system (RAS) plays a major role in its pathogenesis. Within the RAS, angiotensin co... | 20 | 4j8s4r0a | [
"mx4t6s6n",
"r8fmq65g",
"nxx22lcu",
"xzb0sw2z"
] | biomedical_literature_retrieval | scientific |
a0c6e316b3d72b85d303f8e6ae5c23c5 | mteb/trec-covid | what are the guidelines for triaging patients infected with coronavirus? | Surveillance of Acute Respiratory Infections Using Community-Submitted Symptoms and Specimens for Molecular Diagnostic Testing. Participatory systems for surveillance of acute respiratory infection give real-time information about infections circulating in the community, yet to-date are limited to self-reported syndrom... | [
"2264. The Burden of Respiratory Viral Illness in HIV-Infected Patients. BACKGROUND: Among individuals living with human immunodeficiency virus (HIV), pulmonary complications are the most frequent cause of morbidity and mortality. Although bacterial and fungal pathogens are well-described etiologies of lung disease... | 11 | ij9mifov | [
"jzlouns7",
"jc443w2a",
"9807pgmy",
"0smru5k2"
] | biomedical_literature_retrieval | scientific |
c58c77ebaebda91f86a43071f7447e8c | mteb/scifact | Adult tissue-resident macrophages are seeded before birth. | Origin and functions of tissue macrophages.. Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own co... | [
"Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases.. Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whe... | 86 | 22406695 | [
"16863359",
"12827098",
"22973574",
"2604063"
] | scientific_claim_retrieval | scientific |
c213d7c436083708a9c4cf58af4e69bd | mteb/scifact | The deregulated and prolonged activation of monocytes improves inflammatory disease outcomes. | The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.. Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify t... | [
"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Missense mutations in the CIAS1 gene cause three autoinflammatory disorders: familial cold autoinflammatory syndrome, Muckle–Wells syndrome and neonatal-onset multiple-system inflammatory disease. Cryopyrin (also called Nalp3),... | 1214 | 6493422 | [
"4345315",
"13902570",
"2774906",
"21498497"
] | scientific_claim_retrieval | scientific |
407e2ca37ec73981d7fdbc4460da9eb6 | mteb/trec-covid | what causes death from Covid-19? | Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. PURPOSE: Previous studies assessing impact of acute respiratory distress syndrome (ARDS) on mortality have shown conflicting results. We sought to assess the independent association of ARDS with in-hospital mortality amon... | [
"Ebola virus disease and critical illness. As of 20 May 2016 there have been 28,646 cases and 11,323 deaths resulting from the West African Ebola virus disease (EVD) outbreak reported to the World Health Organization. There continue to be sporadic flare-ups of EVD cases in West Africa. EVD presentation is nonspecif... | 4 | omv6rkl1 | [
"qtfdtfq4",
"010xjb35",
"m1jpza1z",
"s7ip4tjj"
] | biomedical_literature_retrieval | scientific |
b0878d76968c009b8681467cba354ca8 | mteb/scifact | In British Men, haplogroup I decreases risk of cardiovascular disease. | Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. BACKGROUND A sexual dimorphism exists in the incidence and prevalence of coronary artery disease--men are more commonly affected than are age-matched women. We explored the role of the Y chromosome in coronary artery disease in ... | [
"The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials. OBJECTIVES To investigate whether statins reduce all cause mortality and major coronary and cerebrovascular events in people without established cardiova... | 563 | 2867345 | [
"5698494",
"409280",
"2052720",
"24396137"
] | scientific_claim_retrieval | scientific |
7b0cda1638fdb3346e03843fb3685802 | mteb/scifact | Induced hepatic stem cells possess the potential to differentiate into hepatocytic cells. | Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors.. Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the blood and neuronal lineages. We previously reported generat... | [
"Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.. Beta-cell replacement is considered to be the most promising approach for treatment of type 1 diabetes. Its application on a large scale is hindered by a shortage of cells for tran... | 625 | 20033112 | [
"37699461",
"6477740",
"36637129",
"14192687"
] | scientific_claim_retrieval | scientific |
e3d33b07d7328d80a951ea2d7d8a4ed4 | mteb/scifact | The gene daf-16, which encodes forkhead Box O (FOXO), is required for all phenotypes associated with reduced insulin/insulin-like growth factor (Igf) signaling. | DAF-16/FOXO employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Organisms are constantly challenged by stresses and privations and require adaptive responses for their survival. The forkhead box O (FOXO) transcription factor DAF-16 (hereafter referred to as DAF-16/FOXO) is a central nex... | [
"Influence of Steroid Hormone Signaling on Life Span Control by Caenorhabditis elegans Insulin-Like Signaling. Sterol-sensing nuclear receptors and insulin-like growth factor signaling play evolutionarily conserved roles in the control of aging. In the nematode Caenorhabditis elegans, bile acid-like steroid hormone... | 1219 | 9393969 | [
"14544564",
"13072113",
"1576955",
"29429111"
] | scientific_claim_retrieval | scientific |
6f1d383b4060e2e7c33ecdf555ca27ce | mteb/scifact | Cytochrome c is transferred from cytosol to the mitochondrial intermembrane space during apoptosis. | At the gates of death.. Apoptosis that proceeds via the mitochondrial pathway involves mitochondrial outer membrane permeabilization (MOMP), responsible for the release of cytochrome c and other proteins of the mitochondrial intermembrane space. This essential step is controlled and mediated by proteins of the Bcl-2 fa... | [
"The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage. Mitochondrial morphological and ultrastructural changes occur during apoptosis and autophagy, but whether they are relevant in vivo for tissue response to damage is unclear. Here we investigate the... | 299 | 39381118 | [
"15836115",
"7465900",
"10698739",
"8654183"
] | scientific_claim_retrieval | scientific |
154c36290c3af24d125876a9b49f11ae | mteb/scifact | Cnn1 recruitment varies with cell cycle timing. | Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore. Kinetochores attach the replicated chromosomes to the mitotic spindle and orchestrate their transmission to the daughter cells. Kinetochore–spindle binding and chromosome segregation are mediated by the multi-copy KNL1Spc105, MIS12Mtw1 a... | [
"Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.. The tumor suppressor protein, p53, plays a critical role in mediating cellular response to stress signals by regulating genes involved in cell cycle arrest and apoptosis. p53 is believed to be inactiv... | 266 | 22405338 | [
"21557055",
"10189634",
"11968641",
"14471161"
] | scientific_claim_retrieval | scientific |
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