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|---|---|---|---|---|---|---|---|---|---|
3c5d2cfa5d257e8339107a4253e23023 | mteb/scifact | YAP/TAZ is required in intestinal regeneration in mouse models of ulcerative colitis. | YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Tissue regeneration requires dynamic cellular adaptation to the wound environment. It is currently unclear how this is orchestrated at the cellular level and how cell fate is affected by severe tissue damage. Here we diss... | [
"Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling.. Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a fundamentally negative impact on metabolism, we show that pro... | 1381 | 13481880 | [
"5106691",
"36310858",
"4465735",
"4447785"
] | scientific_claim_retrieval | scientific |
0df4711794e3a1abb814e8f7f5fc121f | mteb/scifact | Patients with common epithelial cancers are more likely to have an emergency event as their first hospital admission if they live in resource-deprived areas. | Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics. OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by soci... | [
"Feasibility assessment of desalination application in Australian traditional agriculture. Abstract Within some data limitations, the paper provides a first assessment of areas in Australia with potential for implementing desalination technologies to supply agricultural water. At the national scale, these areas wer... | 926 | 16390264 | [
"97566194",
"18574146",
"7547329",
"27188320"
] | scientific_claim_retrieval | scientific |
03e743f3c94ae896708c357b665d4c36 | mteb/trec-covid | are cardiac complications likely in patients with COVID-19? | Prevalence, pathogenesis, therapy, and prevention of cardiovascular events in patients with community-acquired pneumonia. It is now well recognised that cardiac events occur relatively commonly in patients with acute community-acquired pneumonia. While these events are more frequent in patients with underlying risk fac... | [
"Demographic profile and outcome analysis of a tertiary level pediatric intensive care unit. Objective : To study the profile and outcome of children admitted to a tertiary level pediatric intensive care unit (PICU) in India.Methods : Prospective study of patient demographics, PRISM III scores, diagnoses, treatment... | 22 | af94djog | [
"18dxcn41",
"zhw8vh3e",
"1ddfywfa",
"5yt1cgkx"
] | biomedical_literature_retrieval | scientific |
37e063041483c9a0f4b104d9a50ae283 | mteb/scifact | Gastric lavage is an effective treatment for acute paraquat poisoning. | Effect of activated charcoal hemoperfusion on renal function in patients with paraquat poisoning.. The present study retrospectively analyzed 19 patients diagnosed with paraquat (PQ) poisoning with the aim to investigate the effect of activated charcoal hemoperfusion on renal function and PQ elimination. The results in... | [
"Systematic review of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning.. BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to guide therapy, hindering the identification of best th... | 449 | 3430789 | [
"8447873",
"41294031",
"19132741",
"85693958"
] | scientific_claim_retrieval | scientific |
118e83a5bc035de3479eca34ba83a1b8 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | New Insights of an Old Defense System: Structure, Function, and Clinical Relevance of the Complement System. The complement system was discovered a century ago as a potent defense cascade of innate immunity. After its first description, continuous experimental and clinical research was performed, and three canonical pa... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | c2nuh2yc | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
21a89c656013ba16597f4b0af8557208 | mteb/trec-covid | what is known about an mRNA vaccine for the SARS-CoV-2 virus? | Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge. Current hemagglutinin (HA)-based seasonal influenza vaccines induce vaccine strain-specific neutralizing antibodies that usually fail to provide protection against mism... | [
"Gold nanoparticles for preparation of antibodies and vaccines against infectious diseases. Introduction: Vaccination remains very effective in stimulating protective immune responses against infections. An important task in antibody and vaccine preparation is to choose an optimal carrier that will ensure a high im... | 50 | nt1shjtl | [
"1tn3a4qs",
"299oohbp",
"msmq91d2",
"184kmuiy"
] | biomedical_literature_retrieval | scientific |
f9c8fb0a025334f9c3c6b41fee3d3660 | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | Preliminary Findings of a Randomized Trial of Non-Pharmaceutical Interventions to Prevent Influenza Transmission in Households. BACKGROUND: There are sparse data on whether non-pharmaceutical interventions can reduce the spread of influenza. We implemented a study of the feasibility and efficacy of face masks and hand ... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | 543aq9dx | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
feea2ec6922a2be7b5187924ca6c079c | mteb/scifact | Medications to treat obesity are highly effective. | Long term pharmacotherapy for obesity and overweight: updated meta-analysis.. OBJECTIVE To summarise the long term efficacy of anti-obesity drugs in reducing weight and improving health status. DESIGN Updated meta-analysis of randomised trials. DATA SOURCES Medline, Embase, the Cochrane controlled trials register, the ... | [
"Broad neutralization coverage of HIV by multiple highly potent antibodies. Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we probed the neutralizing antibody repertoires of four human immunodeficiency virus ... | 764 | 7552215 | [
"4373433",
"12209494",
"1084062",
"7098463"
] | scientific_claim_retrieval | scientific |
107955063489773f2ebb16bf2e60153d | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Steps to a Sustainable Public Health Surveillance Enterprise A Commentary from the International Society for Disease Surveillance. More than a decade into the 21(st) century, the ability to effectively monitor community health status, as well as forecast, detect, and respond to disease outbreaks and other events of pub... | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | 91uj6sph | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
e61014ef911b057696d7f39ba331c257 | mteb/scifact | Ethanol stress reduces the expression of SRL in bacteria. | Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, ... | [
"Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen.. The physiology of ethanologenic Escherichia coli grown anaerobically in alkali-pretreated plant hydrolysates is complex and not well studied. To gain insight into h... | 393 | 1148122 | [
"21602220",
"13350374",
"22467585",
"10491220"
] | scientific_claim_retrieval | scientific |
9cf3b3097dc1ead0925d45134768ab25 | mteb/scifact | Continued HHV-8 transmission among MSM in San Francisco may be explained by urogenital contact. | Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic.. CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human immu... | [
"Risk of cancer after low doses of ionising radiation: retrospective cohort study in 15 countries.. OBJECTIVES To provide direct estimates of risk of cancer after protracted low doses of ionising radiation and to strengthen the scientific basis of radiation protection standards for environmental, occupational, and ... | 285 | 5548081 | [
"14700857",
"25690564",
"32423829",
"30844602"
] | scientific_claim_retrieval | scientific |
c259c696955b828264911ca6a0a5b006 | mteb/scifact | Replacement of histone H2A with H2A.Z accelerates gene activation in yeasts by destabilizing +1 nucleosomes. | Nucleosome stability mediated by histone variants H3.3 and H2A.Z.. Nucleosomes containing the histone variant H3.3 tend to be clustered in vivo in the neighborhood of transcriptionally active genes and over regulatory elements. It has not been clear, however, whether H3.3-containing nucleosomes possess unique propertie... | [
"Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome. Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, which replaces histone H2A in canonical nucleosomes wi... | 1040 | 25254425 | [
"9451052",
"1259280",
"5966635",
"11844791"
] | scientific_claim_retrieval | scientific |
026670ff43d1508b43fe1a39a67b278d | mteb/scifact | Adult tissue-resident macrophages stem from the embryonal yolk sac and fetal liver. | Origin and functions of tissue macrophages.. Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own co... | [
"A lineage of myeloid cells independent of Myb and hematopoietic stem cells.. Macrophages and dendritic cells (DCs) are key components of cellular immunity and are thought to originate and renew from hematopoietic stem cells (HSCs). However, some macrophages develop in the embryo before the appearance of definitive... | 90 | 22406695 | [
"22973574",
"25994317",
"12827098",
"16863359"
] | scientific_claim_retrieval | scientific |
41e2a00922c15c328fa2f0d3484900a0 | mteb/scifact | MICAL redox enzymes regulate actin dynamics. | Differential regulation of actin microfilaments by human MICAL proteins.. The Drosophila melanogaster MICAL protein is essential for the neuronal growth cone machinery that functions through plexin- and semaphorin-mediated axonal signaling. Drosophila MICAL is also involved in regulating myofilament organization and sy... | [
"Mical links semaphorins to F-actin disassembly. How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studied for their effects on cell movement, navigation, an... | 738 | 6609935 | [
"4417558",
"3506723",
"6784372",
"36345185"
] | scientific_claim_retrieval | scientific |
403f1eaf18866ae23aa0d7f615b131a4 | mteb/scifact | β-sheet opening occurs during pleurotolysin pore formation. | Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin. Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via c... | [
"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.. The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neu... | 1406 | 2617858 | [
"11328820",
"14060030",
"7114092",
"14362678"
] | scientific_claim_retrieval | scientific |
f9fea070c8b6d36c40ba60b2b485ec40 | mteb/scifact | Converting apoE4 to apoE3 by gene editing worsens the pathology associated with apoE4 in human iPSCderived neurons. | Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector. Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using hum... | [
"CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.. Encephalitis and dementia associated with acquired immunodeficiency syndrome (AIDS) are charac... | 287 | 4709641 | [
"27602752",
"16630996",
"10766688",
"8150638"
] | scientific_claim_retrieval | scientific |
126096ba138695ce2455d6840ee3ce20 | mteb/scifact | Cytosolic proteins bind to iron-responsive elements on mRNAs coding for TFRC1. | Mitochondrial iron chelation ameliorates cigarette-smoke induced bronchitis and emphysema in mice. Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic determinants. We have previously identified iron-responsive element-binding protein 2 (IRP2) as an important COPD susceptibility... | [
"Archaeal chromatin and transcription.. Archaea contain a variety of sequence-independent DNA binding proteins consistent with the evolution of several different, sometimes overlapping and exchangeable solutions to the problem of genome compaction. Some of these proteins undergo residue-specific post-translational ... | 301 | 3553087 | [
"40447899",
"21622715",
"13964633",
"8496132"
] | scientific_claim_retrieval | scientific |
2633b8e701bbf0262384b95f8b62558d | mteb/scifact | Bariatric surgery reduces postmenopausal breast cancer. | Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care.. BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large... | [
"Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk.. Epidemiologic studies suggest that ovarian hormones contribute to the development of breast cancer at all stages. Early menopause and premenopausal obesity reduces the risk while postmenopausal obesity and menopausal estrogen repla... | 169 | 5824985 | [
"5864770",
"2931832",
"32534305",
"16098747"
] | scientific_claim_retrieval | scientific |
8d1d04a58de3ae85e27aabdc0cde4ca1 | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | A randomised clinical trial to evaluate the safety, fit, comfort of a novel N95 mask in children. Children are more vulnerable to the risks of air pollution, including susceptibility to acquiring chronic diseases in their developing lungs. Despite these, there are no specific masks designed for and tested in children t... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | 2r62jqsx | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
2ec078254e9317eb9ed4c61680328ab6 | mteb/scifact | In young and middle-aged adults, current or remote uses of ADHD medications increase the risk of serious cardiovascular events. | ADHD medications and risk of serious cardiovascular events in young and middle-aged adults.. CONTEXT More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can increase heart rate and blood pressure, raising concerns ab... | [
"Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study.. CONTEXT The long-term risk for developing hypertension is best described by the lifetime risk statistic. The lifetime risk for hypertension and trends in this risk over time are unknown. OBJECTIVES To esti... | 590 | 10984005 | [
"12206390",
"21048969",
"25451374",
"37583120"
] | scientific_claim_retrieval | scientific |
dba4649d5d9ac14e054684f6b74b7874 | mteb/scifact | PKG-la does not have a large impact on expression of pain hypersensitivity in PGK-la knockout mice. | Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity. Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for ... | [
"Effects of growth hormone and insulin-like growth factor 1 deficiency on ageing and longevity.. Present knowledge on the effects of growth hormone (GH)/insulin-like growth hormone (IGF)1 deficiency on ageing and lifespan are reviewed. Evidence is presented that isolated GH deficiency (IGHD), multiple pituitary hor... | 909 | 11254556 | [
"6313547",
"6820680",
"22800314",
"2062382"
] | scientific_claim_retrieval | scientific |
f0517fd5f2bc4a8dabd315f5c97def86 | mteb/scifact | Ly6C hi monocytes have a higher inflammatory capacity than Ly6C lo monocytes. | Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response.. Blood monocytes are well-characterized precursors for macrophages and dendritic cells. Subsets of human monocytes with differential representation in various disease states are well known. In contrast, mouse monocyte subsets ... | [
"Kruppel-like factor 2 (KLF2) regulates monocyte differentiation and functions in mBSA and IL-1β-induced arthritis.. Kruppel-like factor 2 (KLF2) plays an important role in the regulation of a variety of immune cells, including monocytes. We have previously shown that KLF2 inhibits proinflammatory activation of mon... | 726 | 36444198 | [
"7948486",
"22406695",
"4427060",
"17708753"
] | scientific_claim_retrieval | scientific |
28c44b92c6543c96dfb4d3373df3e786 | mteb/scifact | Patients with panic anxiety show decreased CSF levels of hypocretin. | A KEY ROLE FOR OREXIN IN PANIC ANXIETY. Panic disorder is a severe anxiety disorder with recurrent, debilitating panic attacks. In individuals with panic disorder there is evidence of decreased central gamma-aminobutyric acid (GABA) activity as well as marked increases in autonomic and respiratory responses after intra... | [
"Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. Neutrophil apoptosis is a highly regulated process essential for inflammation resolution, the molecular mechanisms of which are only partially elucidated. In this study, we describe a survival pathway controlle... | 930 | 16056514 | [
"15248287",
"4409524",
"19255949",
"22901758"
] | scientific_claim_retrieval | scientific |
07253f3a2e396ad43baab408c8f0bacc | mteb/scifact | Increased LDL receptors plays a role in the reduction of plasma Lp(a). | Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans. BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have ... | [
"Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. Since Notch signaling plays a critical role in stem cells and oncogenesis, we hypothesized that Notch signaling might play roles in cancer stem cells and cancer cells with a stem cell phenotype. ... | 603 | 6540064 | [
"25050969",
"20761364",
"21372171",
"38023457"
] | scientific_claim_retrieval | scientific |
40a1fd0e7ab09a54f386eae7bbe9727a | mteb/scifact | ATM and Rad3 related protein are critical for sensing DNA damage. | Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.. Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice ... | [
"Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation.. The role of ataxia telangiectasia mutated (ATM), a DNA double-strand break recognition and response protein, in inflammation and inflammatory diseases i... | 63 | 40349336 | [
"5572127",
"30122260",
"36831892",
"25994317"
] | scientific_claim_retrieval | scientific |
b72333447d2c3c430c133a2933fcea7a | mteb/scifact | B3-Galectin decreases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR. | An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition. Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin αvβ3 serves as a marker of breast, lung and pancreatic carcinomas with stem-like properties that are hig... | [
"Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling.. PURPOSE Tyrosine kinase (TK) inhibitors are emerging as a promising new approach to the treatme... | 153 | 4702639 | [
"34016944",
"23420807",
"17462437",
"14241418"
] | scientific_claim_retrieval | scientific |
b387cd4a6592d9faa192bbee84657758 | mteb/scifact | Insulin decreases risk of severe kidney failure. | Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care. OBJECTIVE To assess the risks of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia in patients with type 2 diabetes associated with prescribed... | [
"Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.. Angiotensin converting enzyme (ACE) inhibitors are now one ... | 642 | 13619127 | [
"6157837",
"35766603",
"120626",
"3430789"
] | scientific_claim_retrieval | scientific |
72b59a7ed5b8a3f5b054b70d0384a501 | mteb/scifact | Propriospinal interneurons that play a role in the plastic reorganization of spinal circuits are integral for recovery from spinal cord injury. | Recovery of supraspinal control of stepping via indirect propriospinal relay connections after spinal cord injury. Spinal cord injuries (SCIs) in humans and experimental animals are often associated with varying degrees of spontaneous functional recovery during the first months after injury. Such recovery is widely att... | [
"Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions. Injured axons of the adult CNS undergo lengthy retraction from the initial site of axotomy after spinal cord injury. Macrophage infiltration correlates spatiotempo... | 980 | 20128547 | [
"16905344",
"2335873",
"6153754",
"4447055"
] | scientific_claim_retrieval | scientific |
28d0e872b507995c4fcbb6499e1b35ee | mteb/scifact | HOXB4 is a highly expressed component of cellular secretome from fetal liver cell populations. | Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Successful ex vivo expansion of hematopoietic stem cells (HSCs) would greatly benefit the treatment of disease and the understanding of crucial questions of stem cell biology. Here we show, using microarray studies, that the HSC-support... | [
"Identification of Senescent Cells in the Bone Microenvironment.. Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16Ink4a , profound secretome changes, telomere shortening, and decond... | 493 | 19583924 | [
"25419778",
"515489",
"3756384",
"4325137"
] | scientific_claim_retrieval | scientific |
603ab6c6dc32837bff99e62f36263d55 | mteb/scifact | The density of cytokine receptor bearing cells affects the distance over which cytokines act. | A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System. &NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, we used t... | [
"Cytokine control of memory T-cell development and survival. Evidence has accumulated that cytokines have a fundamental role in the differentiation of memory T cells. Here, we follow the CD8+ T cell from initial activation to memory-cell generation, indicating the checkpoints at which cytokines determine the fate o... | 1210 | 4928282 | [
"13636631",
"219475",
"30468386",
"38830961"
] | scientific_claim_retrieval | scientific |
bcfd1ed37d5ec9f8dc18e62aa7cbfcb0 | mteb/scifact | R2D2 stops miRNA production by increasing the selectivity of Dcr2 for long dsRNA. | Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease.. Drosophila Dicer-2 generates small interfering RNAs (siRNAs) from long double-stranded RNA (dsRNA), whereas Dicer-1 produces microRNAs (miRNAs) from pre-miRNA. What makes the two Dicers specific for their biological substrate... | [
"Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands. Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a number of viruses, particularly of the... | 1001 | 5702790 | [
"6404801",
"15488881",
"13763195",
"86602746"
] | scientific_claim_retrieval | scientific |
29b3ffa7b26ea6bdd024c74070dbd1d4 | mteb/scifact | Inhibiting focal adhesion formation increases the rate at which cells convert mechanical strain into inflammation and fibrosis. | Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Exuberant fibroproliferation is a common complication after injury for reasons that are not well understood. One key component of wound repair that is often overlooked is mechanical force, which regulates cell-matrix interactions ... | [
"α-Catenin as a tension transducer that induces adherens junction development. Adherens junctions (AJs), which are organized by adhesion proteins and the underlying actin cytoskeleton, probably sense pulling forces from adjacent cells and modulate opposing forces to maintain tissue integrity, but the regulatory mec... | 633 | 5172048 | [
"20313748",
"33036897",
"16057926",
"23423230"
] | scientific_claim_retrieval | scientific |
22b2e4e5aa81bff287ca21bff673a2db | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | What are our health expectations in a pandemic? | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | umz2v0ka | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
28e23699c2a7cc1c02fa77130507765b | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Updated rapid risk assessment from ECDC on the outbreak of COVID-19: increased transmission globally | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | bd7whqxf | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
e9c9fdf628a32cc13d51497d1362d22c | mteb/scifact | In breast cancer, the loss of myoepithelial cells promotes the transition of ductal carcinoma in situ to invasive carcinoma. | Regulation of in situ to invasive breast carcinoma transition.. The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model o... | [
"Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model.. To gain insights into the possible role of oestrogen receptor (ER) beta in breast carcinogenesis, immunohistochemical analysis of ER beta was performed on 512... | 570 | 20333864 | [
"24249915",
"31311495",
"22963769",
"15946643"
] | scientific_claim_retrieval | scientific |
995b8ccbe15ec9d7fa18490950762488 | mteb/trec-covid | how long does coronavirus remain stable on surfaces? | Recommendations for the prevention of transmission of SARS during GI endoscopy | [
"Infections and immunological hazards of allogeneic bone transplantation. Allogeneic transplantation of human cancellous and cortical bone is a controversially discussed concept in trauma and orthopaedic surgery. Biological and immunological arguments support transplantation of autologous material whenever this is ... | 16 | alo15byi | [
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2b348132e397b7b1ed685af67a5d2efe | mteb/scifact | Assessing treatment adherence is more beneficial to clinical practice than measuring routine outcomes. | Anxiety. OBJECTIVES To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings. DATA SOURCES Embase, Medline, PsycLIT, Cinahl, Cochrane Controlled Trials Register, and hand searches of key journals. METHODS ... | [
"Advantages and pitfalls of fructosamine and glycated albumin in the diagnosis and treatment of diabetes.. The efficient diagnosis and accurate monitoring of diabetic patients are cornerstones for reducing the risk of diabetic complications. The current diagnostic and prognostic strategies in diabetes are mainly ba... | 134 | 4695046 | [
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] | scientific_claim_retrieval | scientific |
a51d87df871cf5285abe22b0b34de352 | mteb/scifact | There is a positive correlation between hip fractures and statin use. | HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients.. CONTEXT Recent animal studies have found that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) lipid-lowering drugs (statins) substantially increase bone formation, but whether statin use in humans results in clinically meaningful bone form... | [
"Clinical use of bone densitometry: scientific review.. CONTEXT Osteoporosis causes substantial morbidity and costs $13.8 billion annually in the United States. Measurement of bone mass by densitometry is a primary part of diagnosing osteoporosis and deciding a preventive treatment course. Bone mineral densitometry... | 1288 | 4687948 | [
"16812091",
"24596228",
"25175997",
"27550580"
] | scientific_claim_retrieval | scientific |
c7a946c6de2397190d9721275cfb8875 | mteb/scifact | Incidence of 10/66 dementia is lower than the incidence of DSM-IV dementia. | Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study. BACKGROUND Results of the few cohort studies from countries with low incomes or middle incomes suggest a lower incidence of dementia than in ... | [
"\"The contribution of chronic diseases to the prevalence of dependence among older people in Latin America, China and India: a 10/66 Dementia Research Group population-based survey\". BACKGROUND The number of older people is set to increase dramatically worldwide. Demographic changes are likely to result in the ri... | 592 | 14682243 | [
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] | scientific_claim_retrieval | scientific |
57ebb1196d10286a1ee2cf821c9959c6 | mteb/scifact | Incidence of heart failure increased by 10% in women since 1979. | Trends in heart failure incidence and survival in a community-based population.. CONTEXT The epidemic of heart failure has yet to be fully investigated, and data on incidence, survival, and sex-specific temporal trends in community-based populations are limited. OBJECTIVE To test the hypothesis that the incidence of he... | [
"Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study.. RATIONALE Although obstructive sleep apnea is associated with physiological perturbations that increase risk of hypertension and are proatherogenic, it is uncertain whether sleep apnea is associated with increased stroke risk in t... | 594 | 19675911 | [
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] | scientific_claim_retrieval | scientific |
8e0e1f0f62b51256652749b5e94127ba | mteb/scifact | Lack of FGF21 in mice increases life expectancy. | Fibroblast Growth Factor 21 Prevents Atherosclerosis by Suppression of Hepatic Sterol Regulatory Element-Binding Protein-2 and Induction of Adiponectin in Mice. BACKGROUND Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on glucose and lipid metabolism and insulin sensitivity. It acts... | [
"The sheddase ADAM10 is a potent modulator of prion disease. The prion protein (PrP(C)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrP(Sc). Moreover, it has been suggested as a receptor mediating neurotoxicity in common neurodegenerative pro... | 680 | 9315213 | [
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] | scientific_claim_retrieval | scientific |
910370ab03967b8a59c1239082ca13a7 | mteb/trec-covid | what evidence is there for dexamethasone as a treatment for COVID-19? | Glucocorticoid treatment of patients with SARS: implications for mechanisms of immunopathology | [
"Soluble immune checkpoints in cancer: production, function and biological significance. Immune checkpoints play important roles in immune regulation, and blocking immune checkpoints on the cell membrane is a promising strategy in the treatment of cancer. Based on this, monoclonal antibodies are having much rapid d... | 46 | kqf5e9fe | [
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acec4732dde6b71be94ed98d22a7d314 | mteb/scifact | Carriers of HNF4A mutations are at reduced risk for diabetes. | Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene. Background Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant women with... | [
"Management of women who have a genetic predisposition for breast cancer.. The management of women who have a genetic predisposition for breast cancer requires careful planning. Women who have BRCA 1 and BRCA 2 mutations are at increased risk for breast cancer and for other cancers as well, particularly ovarian can... | 229 | 56893404 | [
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] | scientific_claim_retrieval | scientific |
79faa9293a4aabb9caf7750b1bd5bf35 | mteb/scifact | Toll-like receptor (TLR) signaling is involved in the pathogenesis of human MDS. | The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.. Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is activation of the NLRP3 inflammasome, which drives clonal e... | [
"MicroRNA Response of Primary Human Macrophages to Arcobacter Butzleri Infection. The role of microRNAs (miRNAs) in infectious diseases is becoming more and more apparent, and the use of miRNAs as a diagnostic tool and their therapeutic application has become the major focus of investigation. The aim of this study ... | 1306 | 6000423 | [
"14362780",
"17023584",
"25606339",
"9159125"
] | scientific_claim_retrieval | scientific |
277018fe7c4fee4051985ce148b431c8 | mteb/scifact | Cellular clocks are associated with mitosis timing in NIH 3T3 cells. | Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.. Daily synchronous rhythms of cell division at the tissue or organism level are observed in many species and suggest that the circadian clock and cell cycle oscillators are coupled. For mammals, despite known mechanistic i... | [
"BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.. Mutations in BLM cause Bloom's syndrome, a disorder associated with cancer predisposition and chromosomal instability. We investigated whether BLM plays a role in ensuring the faithful chromosom... | 241 | 10608822 | [
"25550665",
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] | scientific_claim_retrieval | scientific |
4f5b4e7f3675dcda965c2816bd3ebfa4 | mteb/scifact | Female carriers of the Apolipoprotein E4 (APOE4) allele have decreased risk for dementia. | Reproductive period and risk of dementia in postmenopausal women.. CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied. OBJECTIVE To determine whether a longer rep... | [
"Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis. Objective. —To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denomina... | 413 | 6309659 | [
"51386222",
"24557631",
"11090688",
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] | scientific_claim_retrieval | scientific |
7d77ef71dcbaf1159d85738075291c2f | mteb/scifact | Obesity raises life quality. | Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.. BACKGROUND The main associations of body-mass index (BMI) with overall and cause-specific mortality can best be assessed by long-term prospective follow-up of large numbers of people. The Prospective Studi... | [
"Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group. INTRODUCTION With the growing number of adult cancer survivors, there is increasing need for information that links potential late and long term effects with specific treatment regim... | 876 | 195689316 | [
"2328272",
"5151024",
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"1180972"
] | scientific_claim_retrieval | scientific |
aad738c854809a13f474595e81323b3b | mteb/scifact | RANK-RANKL pathway signalling has no known association with development of Aire-expressing medullary thymic epithelial cells. | RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of se... | [
"Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment.. Immunosuppressive drugs and cytotoxic chemotherapy agents are designed to kill or suppress autoreactive, alloaggressive, or hyperinflammatory T cells, or disseminate... | 1004 | 3952288 | [
"10162553",
"39128592",
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5156756cca48e4ebdd3e5ab97c993c48 | mteb/scifact | There is no relation between Erythromycin use and hypertrophic pyloric stenosis. | Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study. OBJECTIVE To assess the association between use of macrolide antibiotics in mothers and infants from pregnancy onset until 120 days after birth and infantile hypertrophic pyloric stenosis (IHPS). DESIGN N... | [
"Dealing with substantial heterogeneity in Cochrane reviews. Cross-sectional study. BACKGROUND Dealing with heterogeneity in meta-analyses is often tricky, and there is only limited advice for authors on what to do. We investigated how authors addressed different degrees of heterogeneity, in particular whether they... | 1295 | 21239672 | [
"7547329",
"3190689",
"23122306",
"791050"
] | scientific_claim_retrieval | scientific |
9e84e3cc48134e979dbe597cd4eca810 | mteb/scifact | Microglia are an innate immune cell type of the central nervous system. | Sublime Microglia: Expanding Roles for the Guardians of the CNS. Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt the s... | [
"Dynamics of Microvillus Extension and Tether Formation in Rolling Leukocytes.. P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin mediates leukocyte rolling under conditions of flow. In human neutrophils, a type of leukocyte belonging to the innate immune system, PSGL-1 molecules are located on the ne... | 789 | 15493354 | [
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] | scientific_claim_retrieval | scientific |
0ee56422d27b1d3921d39dbaf73400e6 | mteb/trec-covid | What vaccine candidates are being tested for Covid-19? | Balancing Expediency and Scientific Rigor in Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Development | [
"Neue Impfstoffe gegen Tuberkulose. With about 10 million active disease cases and 1.5 million deaths in 2018, tuberculosis (TB) remains one of the most threatening infectious diseases. Yet, the World Health Organization (WHO) aims to reduce morbidity and mortality by 90 and 95%, respectively, between 2015 and 2035... | 33 | g0yxf99c | [
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d7815f0b46a8cc0c38a04d49bc70e02d | mteb/scifact | Oxidative phosphorylation is one of the primary glycometabolic pathways in cells. | Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport. Fast axonal transport (FAT) requires consistent energy over long distances to fuel the molecular motors that transport vesicles. We demonstrate that glycolysis provides ATP for the FAT of vesicles. Although inhibiting ATP production from mitochond... | [
"Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia.. Differentiation therapy has emerged as a powerful way to target specific hematologic malignancies. One of the best examples is the use of all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL), which has sig... | 900 | 18678095 | [
"9460704",
"19957813",
"236204",
"3882374"
] | scientific_claim_retrieval | scientific |
0d147df1031e5e2e0faaab06195e403d | mteb/scifact | Environmental factors can influence the development of breast cancer. | Gene–environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study. BACKGROUND Information is scarce about the combined effects on breast cancer incidence of low-penetrance genetic susceptibility polymorphisms and environmental factors (reproductive, behavioural, and anthr... | [
"Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk.. Epidemiologic studies suggest that ovarian hormones contribute to the development of breast cancer at all stages. Early menopause and premenopausal obesity reduces the risk while postmenopausal obesity and menopausal estrogen repla... | 381 | 18340282 | [
"5864770",
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] | scientific_claim_retrieval | scientific |
5ed75143780eaf456f9fe3c7f1d328df | mteb/scifact | Genomic aberrations of metastases provide information for targeted therapy. | Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. Human tumors show a high level of genetic heterogeneity, but the processes that influence the timing and route of metastatic dissemination of the subclones are unknown. Here we have used whole-exome sequencing of 103 matched b... | [
"Molecular analysis of circulating tumour cells—biology and biomarkers. Growing evidence for intratumour heterogeneity informs us that single-site biopsies fall short of revealing the complete genomic landscape of a tumour. With an expanding repertoire of targeted agents entering the clinic, screening tumours for g... | 463 | 19736671 | [
"25504006",
"21692235",
"7764903",
"9909405"
] | scientific_claim_retrieval | scientific |
b3eb671cace5c5839ba836c1390cea62 | mteb/scifact | Incidence of 10/66 dementia is higher than the incidence of DSM-IV dementia. | Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study. BACKGROUND Results of the few cohort studies from countries with low incomes or middle incomes suggest a lower incidence of dementia than in ... | [
"Improved prognosis of thoracic aortic aneurysms: a population-based study.. CONTEXT Managing thoracic aortic aneurysms identified incidentally by increased use of computed tomography, echocardiography, and magnetic resonance imaging is problematic, especially in the elderly. OBJECTIVE To ascertain whether the prev... | 591 | 14682243 | [
"30058568",
"24735908",
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"13934676"
] | scientific_claim_retrieval | scientific |
bf9a68e1cb5e2fe8543dff13a2ffcd1e | mteb/scifact | Increased conversion of PGE 2 to PPARy ligand 15-ket-PGE 2 causes accumulation of PGE. | Pharmacological correction of a defect in PPARγ signaling ameliorates disease severity in Cftr-deficient mice. Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (encoded by Cftr) that impair its role as an apical chloride channel that supports bicarbonate transport. Indiv... | [
"Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.. Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammation. PGE(2) is produced within human airways, and both ... | 606 | 712078 | [
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"3127341",
"10883736"
] | scientific_claim_retrieval | scientific |
645201f7ca8e1c0c7e5dcdd7a8106d5c | mteb/scifact | Omnivores produce less trimethylamine N-oxide from dietary I-carnitine than vegans. | Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that metaboli... | [
"Transmission of atherosclerosis susceptibility with gut microbial transplantation.. Recent studies indicate both clinical and mechanistic links between atherosclerotic heart disease and intestinal microbial metabolism of certain dietary nutrients producing trimethylamine N-oxide (TMAO). Here we test the hypothesis... | 881 | 14803797 | [
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"41022628"
] | scientific_claim_retrieval | scientific |
d0c9f97d4a417f8e83abdee8eb6fc83e | mteb/scifact | Polymeal nutrition increases cardiovascular mortality. | The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%.. OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main... | [
"Evaluation of the association between the first observation and the longitudinal change in C-reactive protein, and all-cause mortality.. OBJECTIVE To evaluate the association between vascular inflammation as measured by subacute C-reactive protein (CRP; 1-10 mg/l) and all-cause mortality and the association betwee... | 959 | 8780599 | [
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"9617381",
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] | scientific_claim_retrieval | scientific |
596239c6837d3771be8a709a35bfa8b6 | mteb/scifact | Rapamycin delays aging in fruit flies. | Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster. The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR k... | [
"A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology☆. A recent study revealed a mechanism of delaying aging in yeast by a natural compound which specifically impacts mitochondrial redox processes. In this mecha... | 1015 | 6277638 | [
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"7808055",
"14475235"
] | scientific_claim_retrieval | scientific |
d9c63ffa7d5a7d50334fec9152c756e8 | mteb/scifact | Citrullinated proteins externalized in neutrophil extracellular traps act indirectly to disrupt the inflammatory cycle. | NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.. The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key pathogenic event. Neutroph... | [
"The role of neutrophils in the pathogenesis of systemic lupus erythematosus.. PURPOSE OF REVIEW Recent discoveries implicate neutrophils as important regulators of innate and adaptive immunity and in the development of organ damage in systemic autoimmune diseases, including systemic lupus erythematosus (SLE). RECE... | 263 | 11328820 | [
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"36089763",
"43054703",
"2236768"
] | scientific_claim_retrieval | scientific |
bc663974e09d455f6fb535f4e2fb2c55 | mteb/scifact | Integrated care is successful at tackling multiple comorbidities. | Functional outcomes of multi-condition collaborative care and successful ageing: results of randomised trial. OBJECTIVE To evaluate the effectiveness of integrated care for chronic physical diseases and depression in reducing disability and improving quality of life. DESIGN A randomised controlled trial of multi-condit... | [
"Frailty Syndrome: A Transitional State in a Dynamic Process. Frailty has long been considered synonymous with disability and comorbidity, to be highly prevalent in old age and to confer a high risk for falls, hospitalization and mortality. However, it is becoming recognized that frailty may be a distinct clinical ... | 648 | 15041758 | [
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984c901fdcc59a3b5355d624a59bdc17 | mteb/scifact | Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth. | Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents.. BACKGROUND Little is known about how the intensity of exercise influences cardiovascular fitness and body composition, especially in obese adolescents. OBJECTIVE Our goal was to determine the e... | [
"Consumption of added sugars from liquid but not solid sources predicts impaired glucose homeostasis and insulin resistance among youth at risk of obesity.. Little is known about longitudinal associations between added sugar consumption (solid and liquid sources) and glucose-insulin homeostasis among youth. Caucasi... | 946 | 4463588 | [
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"52865789",
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"41976370"
] | scientific_claim_retrieval | scientific |
3e3a2ae0c764c2e8757b5638e48eed36 | mteb/trec-covid | what is the origin of COVID-19 | Cyberbiosecurity Challenges of Pathogen Genome Databases. Pathogen detection, identification, and tracking is shifting from non-molecular methods, DNA fingerprinting methods, and single gene methods to methods relying on whole genomes. Viral Ebola and influenza genome data are being used for real-time tracking, while f... | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | x6s34z1s | [
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95c8bea38abe5d163287b72c7976f61a | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Comparison of ELISA with electro-chemiluminescence technology for the qualitative and quantitative assessment of serological responses to vaccination. BACKGROUND: Profiling immune responses induced by either infection or vaccination can provide insight into identification of correlates of protection. Furthermore, profi... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | kxa68zbc | [
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"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
f6016514ebe7f7c50ce67dd7657e282b | mteb/trec-covid | how long can the coronavirus live outside the body | BOARD-INVITED REVIEW: Fate and transport of bioaerosols associated with livestock operations and manures. Airborne microorganisms and microbial by-products from intensive livestock and manure management systems are a potential health risk to workers and individuals in nearby communities. This report presents informatio... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | 0v8ltunv | [
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190ab761de2032195f6ab63f72cfbc34 | mteb/scifact | TMEM27 is a marker for beta cells. | Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.. The signals and molecular mechanisms that regulate the replication of terminally differentiated beta cells are unknown. Here, we report the identification and characterization of transmembrane protein 27 (Tmem27, col... | [
"Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Increased lipid supply causes beta cell death, which may contribute to reduced beta cell mass in type 2 diabetes. We investigated whether endoplasmic reticulum (ER) stress is necessary for lipid-induced apoptosis in beta cells and ... | 1133 | 24142891 | [
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] | scientific_claim_retrieval | scientific |
832ce38613789458360e615a020c148a | mteb/scifact | Splenomegaly is observed in knockin mouse lacking the SHP-2 MAPK pathway. | Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.. We generated a series of knockin mouse lines, in which the cytokine receptor gp130-dependent STAT3 and/or SHP2 signals were disrupted, by replacing the mouse gp130 gene with human gp130 mu... | [
"GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations.. GITR (glucocorticoid-induced TNFR family related gene) is a member of the TNFR superfamily (TNFRSF) that is expressed in different cell types, including T lymphocytes. Because of a high homology in its cytoplasm... | 1097 | 26851674 | [
"29288582",
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69f49b9eb3095f651d1d304601b6ca62 | mteb/scifact | Patients in stable partnerships have a slower progression from HIV to AIDS. | Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.. OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). D... | [
"Monitoring effectiveness and safety of Tafamidis in transthyretin amyloidosis in Italy: a longitudinal multicenter study in a non-endemic area. Tafamidis is a transthyretin (TTR) stabilizer able to prevent TTR tetramer dissociation. There have been a few encouraging studies on Tafamidis efficacy in early-onset inh... | 923 | 17077004 | [
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57e515ad979ce2f076780cede847a2ab | mteb/scifact | Malaria has a high vectorial capacity. | Ranking of elimination feasibility between malaria-endemic countries. Experience gained from the Global Malaria Eradication Program (1955-72) identified a set of shared technical and operational factors that enabled some countries to successfully eliminate malaria. Spatial data for these factors were assembled for all ... | [
"ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.. Application of stem cell biology to breast cancer research has been limited by the lack of simple methods for identification and isolation of normal and malignant stem cells. Utilizing in vitro and in vivo... | 753 | 1173667 | [
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0f5385a9a20f8420cc0afa91b3f4286d | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey. BACKGROUND: During the 2009 influenza A/H1N1v pandemic, children were identified as a specific "at risk" group. We conducted a multicentric study to describe pattern of influenza A/H1N1v infection among hospitalized children in Brus... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | 0jlsaypc | [
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6ac4b28ed2e9d4deb28ae8ae074cfa6e | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Molecular Diagnostic Assays for Detection of Viral Respiratory Pathogens in Institutional Outbreaks. Outbreaks of viral respiratory disease in institutions may be associated with high morbidity and mortality, depending upon the viral etiology and the age and immune status of the affected patients. Control of outbreaks ... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | qjab20j6 | [
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] | biomedical_literature_retrieval | scientific |
ae873bc5f3daf9f3a6786b597c39f561 | mteb/trec-covid | will SARS-CoV2 infected people develop immunity? Is cross protection possible? | Macrophage Pattern Recognition Receptors in Immunity, Homeostasis and Self Tolerance. Macrophages, a major component of innate immune defence, express a large repertoire of different classes of pattern recognition receptors and other surface antigens which determine the immunologic and homeostatic potential of these ve... | [
"HBV Immune-Therapy: From Molecular Mechanisms to Clinical Applications. Chronic hepatitis B virus (HBV) infection represents a worldwide public health concern with approximately 250 million people chronically infected and at risk of developing liver cirrhosis and hepatocellular carcinoma. Nucleos(t)ide analogues (... | 3 | y93jzlvo | [
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] | biomedical_literature_retrieval | scientific |
bee5e8abbb0a8087521afbd9292aed7f | mteb/trec-covid | what is the origin of COVID-19 | Virus–Host Coevolution with a Focus on Animal and Human DNA Viruses. Viruses have been infecting their host cells since the dawn of life, and this extremely long-term coevolution gave rise to some surprising consequences for the entire tree of life. It is hypothesised that viruses might have contributed to the formatio... | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | 33fs6exl | [
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5ac2b5fee5e41a41af9ac40a553e3021 | mteb/scifact | Asymptomatic visual impairment screening in elderly populations leads to improved vision. | Effectiveness of screening older people for impaired vision in community setting: systematic review of evidence from randomised controlled trials.. OBJECTIVE To assess whether population screening for impaired vision among older people in the community leads to improvements in vision. DESIGN Systematic review of random... | [
"Variations and Trends in Health Burden of Visual Impairment Due to Cataract: A Global Analysis.. Purpose To evaluate the global trends in health burden of people visually impaired from cataract in terms of disability-adjusted life years (DALY) and its correlations with national levels of socioeconomic development.... | 138 | 26016929 | [
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] | scientific_claim_retrieval | scientific |
275a28173ea427c767edd9982d694c08 | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Technical and Clinical Niches for Point of Care Molecular Devices. A point of care (POC) device is one that is used outside of a central laboratory environment; generally near , or at the site of the patient/client. Point of care testing (POCT) varies from tests performed in physician’s office labs, or “satellite” or “... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | pvlg3nkp | [
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] | biomedical_literature_retrieval | scientific |
89792c6f85f161ac3e803ebf4092a3b7 | mteb/scifact | The deregulated and prolonged activation of monocytes has deleterious effects in chronic infectious conditions. | The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.. Precise control of myeloid cell activation is required for optimal host defense. However, this activation process must be under exquisite control to prevent uncontrolled inflammation. Herein, we identify t... | [
"A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells.. Neurogenesis occurs in the hippocampus of the developing and adult brain due to the presence of multipotent stem cells and restricted precursor cells at different stages of differentiation. It has been p... | 1212 | 6493422 | [
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] | scientific_claim_retrieval | scientific |
2ec42be3e8f1bd11b967052141d01cc9 | mteb/scifact | In pediatric tissue, most T cells are naive T cell emigrants from the thymus. | Early life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues. It is unclear how the immune response in early life becomes appropriately stimulated to provide protection while also avoiding excessive activation as a result of diverse new antigens. T cells are in... | [
"CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization.. Although most vaccines are administered i.m., little is known about the dendritic cells (DCs) that are present within skeletal muscles. In this article, we show that e... | 580 | 23460562 | [
"21719289",
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] | scientific_claim_retrieval | scientific |
62554c59d4d4076e2223d23fbde1cce7 | mteb/scifact | Post-transcriptional handling of mitochondrial transcripts occurs in mitochondrial RNA granules. | The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.. RNA-binding proteins are at the heart of posttranscriptional gene regulation, coordinating the processing, storage, and handling of cellular RNAs. We show here that GRSF1, previo... | [
"Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Post-transcriptional modification of RNA nucleosides occurs in all living organisms. Pseudouridine, the most abundant modified nucleoside in non-coding RNAs, enhances the function of transfer RNA and ribosomal RNA by stabili... | 962 | 935538 | [
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] | scientific_claim_retrieval | scientific |
3de04616f3c26d8e2596e34dc298239f | mteb/scifact | General exercise therapy is more effective than rotator cuff exercises in reducing pain and improving function of the shoulder. | Effect of specific exercise strategy on need for surgery in patients with subacromial impingement syndrome: randomised controlled study. OBJECTIVE To evaluate if a specific exercise strategy, targeting the rotator cuff and scapula stabilisers, improves shoulder function and pain more than unspecific exercises in patien... | [
"High prevalence of asthma in cross country skiers.. OBJECTIVES To study the prevalence of asthma (asthma symptoms and bronchial hyperresponsiveness) in Swedish cross country skiers compared with non-skiers and monitor changes in symptoms and bronchial hyperresponsiveness during the year. DESIGN Cross sectional stu... | 453 | 4200695 | [
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] | scientific_claim_retrieval | scientific |
a8ef65fce4498b37c88178463e1efe2b | mteb/scifact | IL-10 production by monocytes inhibits CD4 + T cell response. | Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Viral replication and microbial translocation from the gut to the blood during HIV infection lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers during HIV infection... | [
"Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.. IL-10 gene transcription and IL-10 protein production was assessed in both type 1 (Th1) and type 2 (Th2) CD4+ human T cell clones by polymerase chain... | 547 | 10648422 | [
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] | scientific_claim_retrieval | scientific |
f7870ef5a54bb2bfb9e5e47826c9976b | mteb/trec-covid | what evidence is there related to COVID-19 super spreaders | Calculating the potential for within-flight transmission of influenza A (H1N1). BACKGROUND: Clearly air travel, by transporting infectious individuals from one geographic location to another, significantly affects the rate of spread of influenza A (H1N1). However, the possibility of within-flight transmission of H1N1 h... | [
"Molecular Genetic Insights on Cheetah (Acinonyx jubatus) Ecology and Conservation in Namibia. The extent and geographic patterns of molecular genetic diversity of the largest remaining free-ranging cheetah population were described in a survey of 313 individuals from throughout Namibia. Levels of relatedness, incl... | 14 | zqcu10rp | [
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53a54a456c1a87cb519d1dc22c8c9b3b | mteb/scifact | In domesticated populations of Saccharomyces cerevisiae, segmental aneuploidy occurs infrequently. | Domestication and Divergence of Saccharomyces cerevisiae Beer Yeasts. Whereas domestication of livestock, pets, and crops is well documented, it is still unclear to what extent microbes associated with the production of food have also undergone human selection and where the plethora of industrial strains originates fro... | [
"Mapping Meiotic Single-Strand DNA Reveals a New Landscape of DNA Double-Strand Breaks in Saccharomyces cerevisiae. DNA double-strand breaks (DSBs), which are formed by the Spo11 protein, initiate meiotic recombination. Previous DSB-mapping studies have used rad50S or sae2Δ mutants, which are defective in break pro... | 574 | 10300888 | [
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] | scientific_claim_retrieval | scientific |
8e6bef83ed1df8d09b299b3edd2208ff | mteb/scifact | The PRDM1 gene, when combined with the PRDM14 gene, plays an important role during primordial germ cell specification. | The Germ Cell Determinant Blimp1 Is Not Required for Derivation of Pluripotent Stem Cells. Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells. They together initiate epigenetic reprogramming in early g... | [
"Relationship between Sloan-Kettering virus expression and mouse follicular development. Sloan-Kettering virus gene product (Ski) is an unique nuclear pro-oncoprotein and belongs to the ski/sno proto-oncogene family. Ski plays multiple roles in a variety of cell types, it can induce both oncogenic transformation an... | 1177 | 13910150 | [
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] | scientific_claim_retrieval | scientific |
d51a9cfbce54b22490b44549df29d76a | mteb/scifact | In S. cerevisiae, the absence of RNA surveillance pathways reduces sensitivity to high iron conditions. | Multiple RNA surveillance pathways limit aberrant expression of iron uptake mRNAs and prevent iron toxicity in S. cerevisiae.. Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracellular iron toxicity. We show that many mRNAs encoding iron u... | [
"Pseudo-Seq: Genome-Wide Detection of Pseudouridine Modifications in RNA.. RNA molecules contain a variety of chemically diverse, posttranscriptionally modified bases. The most abundant modified base found in cellular RNAs, pseudouridine (Ψ), has recently been mapped to hundreds of sites in mRNAs, many of which are... | 566 | 16120395 | [
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] | scientific_claim_retrieval | scientific |
bd0ed82f3ac91121de5ca88663cba545 | mteb/trec-covid | how has COVID-19 affected Canada | Market Area Delineation for Airports to Predict the Spread of Infectious Disease. Air travel facilitates the international spread of infectious disease. While global air travel data represent the volume of travel between airports, identifying which airport an infected individual might use, or where a disease might spre... | [
"Effects of memory on the shapes of simple outbreak trees. Genomic tools, including phylogenetic trees derived from sequence data, are increasingly used to understand outbreaks of infectious diseases. One challenge is to link phylogenetic trees to patterns of transmission. Particularly in bacteria that cause chroni... | 9 | 6apsd91c | [
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] | biomedical_literature_retrieval | scientific |
bdf3de09c112da1c386d9b04c11614ec | mteb/scifact | Systemic immunosuppressive (IS) therapy increases the chance of cancer mortality in patients with inflammatory eye disease (IED) | Overall and cancer related mortality among patients with ocular inflammation treated with immunosuppressive drugs: retrospective cohort study.. CONTEXT Whether immunosuppressive treatment adversely affects survival is unclear. OBJECTIVE To assess whether immunosuppressive drugs increase mortality. DESIGN Retrospective ... | [
"Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.. CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. ... | 1126 | 21009874 | [
"24341590",
"42731834",
"30398773",
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] | scientific_claim_retrieval | scientific |
67206b5dabae0a0281a96d806ac5234e | mteb/scifact | Persister cells provide relapse resistance in cancer patients. | A framework for understanding and targeting residual disease in oncogene-driven solid cancers. Molecular targeted therapy has the potential to dramatically improve survival in patients with cancer. However, complete and durable responses to targeted therapy are rare in individuals with advanced-stage solid cancers. Eve... | [
"Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy. The aim of the present study was to investigate whether the gene expression levels of LKB1 and LGR5 correlated with clinical outcome in patient... | 938 | 26231129 | [
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"3376731",
"10024681"
] | scientific_claim_retrieval | scientific |
ec918b77da9d575c27301f949761f1e6 | mteb/scifact | miR-142-5P is a known regulator of raised body temperature. | RBM3 regulates temperature sensitive miR-142–5p and miR-143 (thermomiRs), which target immune genes and control fever. Fever is commonly used to diagnose disease and is consistently associated with increased mortality in critically ill patients. However, the molecular controls of elevated body temperature are poorly un... | [
"Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease.. 5-Hydroxymethylcytosine (5-hmC) may represent a new epigenetic modification of cytosine. While the dynamics of 5-hmC during neurodevelopment have recently been reported, little is known about its genomic distribution and function(s) ... | 1391 | 6766459 | [
"1871499",
"2356950",
"1346695",
"11565780"
] | scientific_claim_retrieval | scientific |
bc57c37d0631b86488a12fcda5db7d95 | mteb/scifact | RA activation of DIF2 and NB4 cells induces hallmarks of transcriptionally active promoters. | Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors. Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose lig... | [
"Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCKindependent mechanism. The transition of cell–matrix adhesions from the initial punctate focal complexes into the mature elongated form, known as focal contacts, requires GTPas... | 1002 | 13639330 | [
"9507605",
"18447487",
"14145440",
"4465608"
] | scientific_claim_retrieval | scientific |
5fa5bc00f8a86e12d49decaf653446d8 | mteb/trec-covid | how long can the coronavirus live outside the body | Protection of Upper Respiratory Tract, Mouth and Eyes. Pathogenic bacteria and viruses may invade via upper and lower respiratory tract and via eye mucosa. When an infected person coughs or sneezes heavily, small, invisible droplets with the infective agent may reach a good distance from the source. By using the right ... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | k4lzwfge | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
09db9b74a1203b9c6577610c1cc91936 | mteb/scifact | A deficiency of folate increases blood levels of homocysteine. | Randomized trial of folic acid supplementation and serum homocysteine levels.. BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (relevan... | [
"Original Article. UNLABELLED Fruit and vegetable consumption has been inversely associated with the risk of chronic diseases including cancer and cardiovascular disease, with the beneficial effects attributed to a variety of protective antioxidants, carotenoids and phytonutrients. The objective of the present stud... | 34 | 11705328 | [
"15615957",
"16252863",
"4442799",
"20083834"
] | scientific_claim_retrieval | scientific |
28ffcb88ca78a2ef9ad3e4d4944419df | mteb/scifact | T cell receptor /CD3 microdomains are required to induce the immunologic synapse. | Full activation of the T cell receptor requires both clustering and conformational changes at CD3.. T cell receptor (TCR-CD3) triggering involves both receptor clustering and conformational changes at the cytoplasmic tails of the CD3 subunits. The mechanism by which TCRalphabeta ligand binding confers conformational ch... | [
"TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.. Modified anti-CD3 mAbs are emerging as a possible means of inducing immunologic tolerance in settings including transplantation and autoimmunity such as in type 1 diabetes. In a trial of a modified anti-CD3 mAb ... | 1128 | 33499189 | [
"24069089",
"994800",
"39539647",
"21719289"
] | scientific_claim_retrieval | scientific |
9b65509e8ae2f88f09b525bba3d2fb87 | mteb/scifact | Human embryonic stem cells give rise to cell types from the outer embryonic germ layer, but not the other two layers. | Characterization and culture of human embryonic stem cells. Objective To explore the in vitro maintenance and characterization of human embryonic stem cells(hESCs).Methods hESCs were cultured on feeder layer with ES culture medium,which consists of 20% Knockout Serum Replacement,Knockout DMEM and 10 ng/mL bFGF.Undiffer... | [
"Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maintaining expression of markers characteristic of plur... | 530 | 87610599 | [
"3360421",
"32797183",
"11335860",
"26374799"
] | scientific_claim_retrieval | scientific |
c01d10db54afe55913d7697030ed4898 | mteb/scifact | A 100g dose of chloroquine chemoprophylactic regimen results in retinal toxicity after 5-6 years of weekly intake. | Prevention of malaria in long-term travelers.. CONTEXT Long-term travelers, defined here as those traveling for periods of 6 months or longer, face particular challenges regarding malaria prevention. Current guidelines for malaria prevention primarily address prevention of Plasmodium falciparum infections in short-term... | [
"Safety, pharmacokinetics and efficacy of IMCgp100, a first-in-class soluble TCR-antiCD3 bispecific t cell redirector with solid tumour activity: Results from the FIH study in melanoma.. 3016Background: T cell-based bispecific agents have shown activity in hematologic cancers, but solid tumor efficacy remains elusi... | 27 | 32390525 | [
"79696454",
"2475059",
"35301079",
"12810152"
] | scientific_claim_retrieval | scientific |
ae6782ae30133ba4a97f40b826f6e82d | mteb/scifact | LRBA prevents CTLA - 4 recycling. | Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family in which five individuals presented with a complex, aut... | [
"CD4+ T cell-mediated cytotoxicity eliminates primary tumor cells in metastatic melanoma through high MHC class II expression and can be enhanced by inhibitory receptor blockade. Metastatic melanoma is a rapidly progressing disease with high mortality rate and limited treatment options. Immunotherapy based on tumor... | 676 | 857189 | [
"15128866",
"22968257",
"13398997",
"25677651"
] | scientific_claim_retrieval | scientific |
06b526be56ef08bd1314def19957f9df | mteb/scifact | Sympathetic nerve activity is reduced throughout normal pregnancy. | Sympathetic baroreflex gain in normotensive pregnant women.. Muscle sympathetic nerve activity is increased during normotensive pregnancy while mean arterial pressure is maintained or reduced, suggesting baroreflex resetting. We hypothesized spontaneous sympathetic baroreflex gain would be reduced in normotensive pregn... | [
"Antioxidant Defenses in the Rat Placenta in Late Gestation: Increased Labyrinthine Expression of Superoxide Dismutases, Glutathione Peroxidase 3, and Uncoupling Protein 21. Placental oxidative stress plays a key role in the pathophysiology of placenta-related disorders, most notably preeclampsia (PE) and intrauter... | 1120 | 18997216 | [
"25293721",
"39776978",
"12130067",
"9197786"
] | scientific_claim_retrieval | scientific |
d77511b52de20aed53311f8c14ee6c36 | mteb/scifact | The DEXI promoter region is bound by multiple transcription factors in a murine haematopoietic progenitor cell line. | Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.. Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome... | [
"Promoter decoding of transcription factor dynamics involves a trade-off between noise and control of gene expression. Numerous transcription factors (TFs) encode information about upstream signals in the dynamics of their activation, but how downstream genes decode these dynamics remains poorly understood. Using m... | 1161 | 13048272 | [
"9724974",
"23180075",
"25148216",
"25994317"
] | scientific_claim_retrieval | scientific |
ff95a424912412f9e446540707a681a3 | mteb/scifact | RANK-RANKL pathway signalling is linked to development of Aire-expressing medullary thymic epithelial cells. | RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. Aire-expressing medullary thymic epithelial cells (mTECs) play a key role in preventing autoimmunity by expressing tissue-restricted antigens to help purge the emerging T cell receptor repertoire of se... | [
"Control of central and peripheral tolerance by Aire.. The negative selection of self-reactive thymocytes depends on the expression of tissue-specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even ... | 1005 | 3952288 | [
"39559521",
"13989491",
"10162553",
"17844478"
] | scientific_claim_retrieval | scientific |
98a239ca69ad355abe2a032ba55a7e93 | mteb/scifact | Lysine histone demethylase inhibitor JIB 04 is inactive against KDM5A. | A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signalling pathways simultaneously. Here, using an innovative cell-based s... | [
"Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia. PURPOSE Acute myeloid leukemia (AML) is a heterogeneous disease with poor outcomes. Despite increased evidence shows that dysregulation of histone modification contributes to AML, specific drugs targeting key ... | 730 | 13400643 | [
"4387494",
"4547102",
"18841257",
"15803282"
] | scientific_claim_retrieval | scientific |
706bad2e2185d209e9210cd0f8e1059d | mteb/scifact | Adult tissue-resident macrophages possess a self-renewing capacity. | Origin and functions of tissue macrophages.. Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes. Each tissue has its own co... | [
"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.. Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis... | 88 | 22406695 | [
"12827098",
"20186814",
"36637129",
"4381486"
] | scientific_claim_retrieval | scientific |
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