id stringlengths 32 32 | source_dataset stringclasses 2
values | query stringlengths 26 249 | positive stringlengths 20 1.8k | negatives listlengths 4 4 | query_id stringlengths 1 4 | positive_id stringlengths 4 9 | negative_ids listlengths 4 4 | task_type stringclasses 2
values | domain stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|
cfe7abe6e3de2c5f1d03d86c8f6da9d9 | mteb/trec-covid | what are best practices in hospitals and at home in maintaining quarantine? | Dementia care during COVID-19 | [
"Evacuation of Intensive Care Units During Disaster: Learning From the Hurricane Sandy Experience. OBJECTIVE: Data on best practices for evacuating an intensive care unit (ICU) during a disaster are limited. The impact of Hurricane Sandy on New York City area hospitals provided a unique opportunity to learn from th... | 12 | n5xlpqms | [
"gqa526yl",
"4y5ofjgt",
"aqv7xhng",
"yo4arwoi"
] | biomedical_literature_retrieval | scientific |
bf9e66faa9b0b3a04d120cf5bea74da9 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Mathematical Modeling of the Effectiveness of Facemasks in Reducing the Spread of Novel Influenza A (H1N1). On June 11, 2009, the World Health Organization declared the outbreak of novel influenza A (H1N1) a pandemic. With limited supplies of antivirals and vaccines, countries and individuals are looking at other ways ... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | 36bfeoqv | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
07bf97b049dadb5b9d048e52ba9f5beb | mteb/scifact | Satellite cell dysfunction is a key factor in sarcopenia development. | Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. A key determinant of geriatric frailty is sarcopenia, the age-associated loss of skeletal muscle mass and strength. Although the etiology of sarcopenia is unknown, the correlation during ag... | [
"Recent developments and complexities in neutrophil transmigration.. PURPOSE OF REVIEW As the migration of neutrophils from blood to inflamed tissues is an essential component of innate immunity and a key contributing factor to the pathogenesis of inflammatory disorders, this aspect of leukocyte biology continues t... | 1065 | 20418809 | [
"20608982",
"1866911",
"24974080",
"32776084"
] | scientific_claim_retrieval | scientific |
78aa56a22084e8300bc0416e004c697f | mteb/scifact | Ambulatory blood pressure monitoring is inaccurate at diagnosing hypertension. | Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study.. BACKGROUND The diagnosis of hypertension has traditionally been based on blood-pressure measurements in the clinic, but home and ambulatory measurements better correlate with cardiovascular outcome, and ambulator... | [
"Impact of blood pressure variability on cardiovascular events in elderly patients with hypertension.. Blood pressure variability is one of the characteristic features of hypertension in the elderly. However, its clinical significance remains to be determined. We therefore examined the impact of blood pressure vari... | 106 | 5151024 | [
"54490092",
"22730024",
"15663829",
"3825750"
] | scientific_claim_retrieval | scientific |
7e8d074347acefe459b57730225bff12 | mteb/trec-covid | What is the mechanism of inflammatory response and pathogenesis of COVID-19 cases? | Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome. PURPOSE: Macrophages are highly plastic cells. Under different stimuli, macrophages can be polarized into several different subsets. Two main macrophage subsets have been suggested: classically activated o... | [
"Microglia Are Essential to Protective Antiviral Immunity: Lessons From Mouse Models of Viral Encephalitis. Viral encephalitis is a rare but clinically serious consequence of viral invasion of the brain and insight into its pathogenesis is urgently needed. Important research questions concern the involvement of the... | 38 | 385zahuo | [
"ti2fr0uh",
"ce3sd1ju",
"iacifhko",
"jrdf781h"
] | biomedical_literature_retrieval | scientific |
3a02edfcadd1c788c56105cc0f109823 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Severity and outcomes of influenza-related pneumonia in type A and B strains in China, 2013–2019. BACKGROUND: Inconsistencies exist regarding the severity of illness caused by different influenza strains. The aim of this study was to compare the clinical outcomes of hospitalized adults and adolescents with influenza-re... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | fn3ehf2a | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
490877c1dc0ccd624c6006cc76b82916 | mteb/scifact | Environmentally-induced senescence is mimicked in disease modeling by adding specific molecules to the culture system. | Human iPSC-based modeling of late-onset disease via progerin-induced aging.. Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) resets their identity back to an embryonic age and, thus, presents a significant hurdle for modeling late-onset disorders. In this study, we describe a strategy for inducing... | [
"Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia.. BACKGROUND & AIMS Chronic infection with the bacterial pathogen Helicobacter pylori causes gastric disorders, ranging from chronic gastritis to gastric adenocarcinoma. Only a subset of infected persons will develop over... | 382 | 11659421 | [
"39550665",
"28392393",
"3056682",
"27772649"
] | scientific_claim_retrieval | scientific |
1bc659a8cb99386f3723d81925a4e745 | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Evaluation of Diagnostic Performance of Three Indirect Enzyme-Linked Immunosorbent Assays for the Detection of IgG Antibodies to Ebola Virus in Human Sera. Filovirus serological diagnosis and epidemiological investigations are hampered due to the unavailability of validated immunoassays. Diagnostic performance of three... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | k8wfyj9b | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
faac1f47b57bb546119f95a2b6612181 | mteb/trec-covid | are cardiac complications likely in patients with COVID-19? | Infections in Heart, Lung, and Heart-Lung Transplantation. Half a century has passed since the first orthotopic heart transplant took place. Surgical innovations allowed for heart, lung, and heart-lung transplantation to save lives of patients with incurable chronic cardiopulmonary conditions. The complexity of the sur... | [
"Demographic profile and outcome analysis of a tertiary level pediatric intensive care unit. Objective : To study the profile and outcome of children admitted to a tertiary level pediatric intensive care unit (PICU) in India.Methods : Prospective study of patient demographics, PRISM III scores, diagnoses, treatment... | 22 | tzuyo6tx | [
"18dxcn41",
"zhw8vh3e",
"1ddfywfa",
"5yt1cgkx"
] | biomedical_literature_retrieval | scientific |
d9eb6cb61f553660bf3bc7eaf4f1040c | mteb/scifact | Ribosome-inactivating protein-2 (RIP-2) interacts with the p75 NTR death domain | Gamma-Secretase Represents a Therapeutic Target for the Treatment of Invasive Glioma Mediated by the p75 Neurotrophin Receptor. The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that n... | [
"Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains.. Early region 3 (E3) of group C human adenoviruses (Ad) encodes several inhibitors of tumor necrosis factor alpha (TNF-alpha) cytolysis, including an E3 14.... | 1047 | 14706752 | [
"207972",
"2316374",
"34439544",
"2494748"
] | scientific_claim_retrieval | scientific |
8c7741f312c377f6c5325997baceb374 | mteb/scifact | CDK6 shows improved binding to loss-of-function variants of p18 INK4C. | Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme.. Genomic alterations leading to aberrant activation of cyclin/cyclin-dependent kinase (cdk) complexes drive the pathogenesis of many common human tumor types. In the case of glioblastoma multiforme (GBM), these alterations are most commo... | [
"Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors. Since it was discovered that the anti-hypertensive agent ifenprodil has neuroprotective activity through its effects on NMDA (N-methyl-D-aspartate) receptors, a determined effort has been made to understand the mechanism of action a... | 205 | 470625 | [
"4425507",
"23698769",
"11557602",
"7717468"
] | scientific_claim_retrieval | scientific |
6ca0cab35f32ae6e3eb1246983a91079 | mteb/trec-covid | what are the benefits and risks of re-opening schools in the midst of the COVID-19 pandemic? | The impact of media coverage on the transmission dynamics of human influenza. BACKGROUND: There is an urgent need to understand how the provision of information influences individual risk perception and how this in turn shapes the evolution of epidemics. Individuals are influenced by information in complex and unpredic... | [
"On pandemics and the duty to care: whose duty? who cares?. BACKGROUND: As a number of commentators have noted, SARS exposed the vulnerabilities of our health care systems and governance structures. Health care professionals (HCPs) and hospital systems that bore the brunt of the SARS outbreak continue to struggle w... | 48 | vg42z900 | [
"58czem0j",
"zhw8vh3e",
"upya9ehz",
"3emzk5by"
] | biomedical_literature_retrieval | scientific |
99412715142f7a826236adfe383c926e | mteb/scifact | Intra-cerebroventricular infusion of amyloid-β oligomers increases expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi. | Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-boun... | [
"Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Increased lipid supply causes beta cell death, which may contribute to reduced beta cell mass in type 2 diabetes. We investigated whether endoplasmic reticulum (ER) stress is necessary for lipid-induced apoptosis in beta cells and ... | 654 | 57574395 | [
"25510546",
"23746313",
"207972",
"9767444"
] | scientific_claim_retrieval | scientific |
2921ef4025612d18b0643d2db4c691dd | mteb/scifact | Female carriers of the Apolipoprotein E4 (APOE4) allele have increased risk for Alzheimer's disease. | Reproductive period and risk of dementia in postmenopausal women.. CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied. OBJECTIVE To determine whether a longer rep... | [
"Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector. Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Usin... | 414 | 6309659 | [
"4709641",
"37583120",
"12443371",
"20937018"
] | scientific_claim_retrieval | scientific |
00b5b90c53a8951d7f9ef057cd98b409 | mteb/scifact | 32% of liver transplantation programs required patients to discontinue methadone treatment in 2001. | Liver transplantation and opioid dependence.. ContextChronic hepatitis C is the leading cause for liver transplantation in the United States. Intravenous drug use, the major risk factor, accounts for approximately 60% of hepatitis C virus transmission. Information from the United Network of Organ Sharing (UNOS) does no... | [
"Adverse Events Associated With the Treatment of Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis.. Multidrug-resistant tuberculosis (MDR-TB) is a growing public health problem. Due to long duration of therapy and concurrent use of multiple second-line drugs, adverse drug events (ADEs) are re... | 9 | 44265107 | [
"11254040",
"29564505",
"24069089",
"26124606"
] | scientific_claim_retrieval | scientific |
66f29c0957b42019b6b7cab81510143a | mteb/trec-covid | what evidence is there for dexamethasone as a treatment for COVID-19? | Punica granatum L. Leaf Extract Attenuates Lung Inflammation in Mice with Acute Lung Injury. The hydroalcoholic extract of Punica granatum (pomegranate) leaves was previously demonstrated to be anti-inflammatory in a rat model of lipopolysaccharide- (LPS-) induced acute peritonitis. Here, we investigated the anti-infla... | [
"Soluble immune checkpoints in cancer: production, function and biological significance. Immune checkpoints play important roles in immune regulation, and blocking immune checkpoints on the cell membrane is a promising strategy in the treatment of cancer. Based on this, monoclonal antibodies are having much rapid d... | 46 | 0e9lq1b5 | [
"d3d1n9qa",
"36gbl7tu",
"72s8wpla",
"cpjlzutk"
] | biomedical_literature_retrieval | scientific |
c5a157de8dfeccb3ea8ad5c242fc3574 | mteb/scifact | Antiretroviral therapy increases rates of tuberculosis across a broad range of CD4 strata. | Antiretroviral Therapy for Prevention of Tuberculosis in Adults with HIV: A Systematic Review and Meta-Analysis. BACKGROUND Human immunodeficiency virus (HIV) infection is the strongest risk factor for developing tuberculosis and has fuelled its resurgence, especially in sub-Saharan Africa. In 2010, there were an estim... | [
"Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.. OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAAR... | 123 | 4883040 | [
"17077004",
"13899137",
"31363207",
"35008773"
] | scientific_claim_retrieval | scientific |
5decf6e08eeeb03be99faab7a6c242ed | mteb/scifact | MFGE8 regulates fat absorption by binding to av-Beta3 and av-Beta5 integrins. | Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in h... | [
"Integrins promote cytokinesis through the RSK signaling axis.. Cytokinesis is the final stage in cell division. Although integrins can regulate cytokinesis, the mechanisms involved are not fully understood. In this study, we demonstrate that integrin-regulated ERK (extracellular signal-related kinase) and RSK (p90... | 736 | 5389095 | [
"5321708",
"23420615",
"3590806",
"10669582"
] | scientific_claim_retrieval | scientific |
e5a9ba1d1ff4a9286f168eeff633bc42 | mteb/scifact | Energy balance requires hypothalamic glutamate neurotransmission. | Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone. AgRP neuron activity drives feeding and weight gain whereas that of nearby POMC neurons does the opposite. However, the role of excitatory glutamatergic input in controlling these neurons is unknown. To a... | [
"The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.. BACKGROUND Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Syste... | 378 | 10534299 | [
"4700428",
"16398827",
"2481032",
"14782049"
] | scientific_claim_retrieval | scientific |
435a1efb51520609c8dd4e9aefbc434f | mteb/scifact | Ethanol stress increases the expression of PSP in bacteria. | Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, ... | [
"Complex physiology and compound stress responses during fermentation of alkali-pretreated corn stover hydrolysate by an Escherichia coli ethanologen.. The physiology of ethanologenic Escherichia coli grown anaerobically in alkali-pretreated plant hydrolysates is complex and not well studied. To gain insight into h... | 390 | 1148122 | [
"21602220",
"6948886",
"15286783",
"31803596"
] | scientific_claim_retrieval | scientific |
87b813f2e917e77063d8dcaf7cd2adf5 | mteb/scifact | RTEL1 interacts with TRF2 through a C4C4 motif | TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding. The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telo... | [
"The Ran GTPase regulates mitotic spindle assembly. Ran is an abundant nuclear GTPase with a clear role in nuclear transport during interphase but with roles in mitotic regulation that are less well understood. The nucleotide-binding state of Ran is regulated by a GTPase activating protein, RanGAP1, and by a guanin... | 1006 | 4926049 | [
"14119470",
"23513818",
"11535539",
"26118532"
] | scientific_claim_retrieval | scientific |
35c5c2f62d68d99a9d047318c7f8dce7 | mteb/trec-covid | what drugs have been active against SARS-CoV or SARS-CoV-2 in animal studies? | Potential therapies for coronaviruses. Coronavirus replication offers several attractive targets for chemotherapy. These include: viral entry (inhibited by chloroquine and peptides); viral RNA (targeted by antisense approaches/RNAi); the main protease 3CLpro (inhibited by peptidic molecules such as HIV-1 protease inhib... | [
"Emerging Animal Coronaviruses: First SARS and Now MERS. The first major pandemic of the new millennium that arose from southern China in 2002 was of zoonotic origin from wild game animals, called severe acute respiratory syndrome [SARS]. The culprit was determined to be a coronavirus of animal origin [SARS-CoV]. T... | 5 | z739ifu5 | [
"3114rz8f",
"qilqtvzt",
"zrobpop6",
"isvkp4d1"
] | biomedical_literature_retrieval | scientific |
7ededecb454f1cd09eff0e980d36b492 | mteb/scifact | The mean suicide rate in women is lower after miscarriage than live birth. | Suicides after pregnancy in Finland, 1987-94: register linkage study.. OBJECTIVE To determine rates of suicide associated with pregnancy by the type of pregnancy. DESIGN Register linkage study. Information on suicides in women of reproductive age was linked with the Finnish birth, abortion, and hospital discharge regis... | [
"Perinatal mortality in rural China: retrospective cohort study.. OBJECTIVES To explore the use of local civil registration data to assess the perinatal mortality in a typical rural county in a less developed province in China, 1999-2000. DESIGN Retrospective cohort study. Pregnancies in a cohort of women followed ... | 1228 | 25641414 | [
"7662395",
"30058568",
"37583120",
"18340282"
] | scientific_claim_retrieval | scientific |
5ea69022d019f12a30e903e3b090c172 | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome. PURPOSE: Macrophages are highly plastic cells. Under different stimuli, macrophages can be polarized into several different subsets. Two main macrophage subsets have been suggested: classically activated o... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | 385zahuo | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
99a07295931962838a79e63eba392ccc | mteb/scifact | The H2A-H2B eviction defect is compensated for by other histone chaperone(s). | FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.. FACT, a heterodimer of Spt16 and Pob3, is an essential histone chaperone. We show that the H2A-H2B binding activity that is central to FACT function resides in short acidic regions near the C termini of each subunit. Mutations through... | [
"Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical Nucleosome. Histone variant H2A.Z-containing nucleosomes are incorporated at most eukaryotic promoters. This incorporation is mediated by the conserved SWR1 complex, which replaces histone H2A in canonical nucleosomes wi... | 1166 | 9889151 | [
"9451052",
"5704562",
"12232678",
"8411251"
] | scientific_claim_retrieval | scientific |
c1b1fd950ff9d713bb06e21fcaf5d66d | mteb/trec-covid | What is the mechanism of cytokine storm syndrome on the COVID-19? | TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection. Dysregulated Toll-like receptor (TLR)-4 activation is involved in acute systemic sepsis, chronic inflammatory diseases, such as atherosclerosis and diabetes, a... | [
"Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion. Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection. Additionally, spans of asymptomatic persistence in recovering survivors is possible, durin... | 39 | twxb80vs | [
"32zroj99",
"daycobqe",
"hx6lkuj0",
"ts89jxrz"
] | biomedical_literature_retrieval | scientific |
af33cc01ee4f0262be10aef6373c3fbf | mteb/scifact | Bacteriophagaes MS2 and Qβ are members of the Leviviridae. | Asymmetric cryo-EM reconstruction of phage MS2 reveals genome structure in situ. In single-stranded ribonucleic acid (RNA) viruses, virus capsid assembly and genome packaging are intertwined processes. Using cryo-electron microscopy and single particle analysis we determined the asymmetric virion structure of bacteriop... | [
"Potential role of NF-kappaB in adult neural stem cells: the underrated steersman?. Neural stem cells are precursors of neurons and glial cells. During brain development, these cells proliferate, migrate and differentiate into specific lineages. Recently neural stem cells within the adult central nervous system wer... | 161 | 6903077 | [
"23535770",
"1332250",
"25994317",
"18924534"
] | scientific_claim_retrieval | scientific |
9f0131b2d375164750c53d86e4956b28 | mteb/scifact | Anthrax spores are very difficult to dispose once they are dispersed. | Secondary aerosolization of viable Bacillus anthracis spores in a contaminated US Senate Office.. CONTEXT Bioterrorist attacks involving letters and mail-handling systems in Washington, DC, resulted in Bacillus anthracis (anthrax) spore contamination in the Hart Senate Office Building and other facilities in the US Cap... | [
"Interchangeability of Biosimilars: A European Perspective. Many of the best-selling ‘blockbuster’ biological medicinal products are, or will soon be, facing competition from similar biological medicinal products (biosimilars) in the EU. Biosimilarity is based on the comparability concept, which has been used succe... | 114 | 33872649 | [
"5956016",
"22490293",
"45218443",
"4899981"
] | scientific_claim_retrieval | scientific |
5fb20856b0dd1270c74eccb5ff98e338 | mteb/scifact | Most termination events in Okazaki fragments are dictated by initiation patterns. | Quantitative, genome-wide analysis of eukaryotic replication initiation and termination.. Many fundamental aspects of DNA replication, such as the exact locations where DNA synthesis is initiated and terminated, how frequently origins are used, and how fork progression is influenced by transcription, are poorly underst... | [
"Computational analysis of 3'-ends of ESTs shows four classes of alternative polyadenylation in human, mouse, and rat.. Alternative initiation, splicing, and polyadenylation are key mechanisms used by many organisms to generate diversity among mature mRNA transcripts originating from the same transcription unit. Wh... | 807 | 36606083 | [
"21853444",
"10831818",
"26008462",
"6407356"
] | scientific_claim_retrieval | scientific |
4b5f6fea6bee34f6b059d77e9cc081b7 | mteb/scifact | Monoclonal antibody targeting of N-cadherin encourages metastasis. | Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance. The transition from androgen-dependent to castration-resistant prostate cancer (CRPC) is a lethal event of uncertain molecular etiology. Comparing gene expression in isogenic androgen-dependent and CRPC xe... | [
"Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape. Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine. Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have been unsuccessful, a minority of in... | 802 | 22180793 | [
"7177329",
"3727986",
"14471161",
"4340509"
] | scientific_claim_retrieval | scientific |
21b302571218d499d92dbc819843de4b | mteb/scifact | Pharmacist attendance at ward rounds increases adverse events in wards. | Pharmacist participation on physician rounds and adverse drug events in the intensive care unit.. CONTEXT Pharmacist review of medication orders in the intensive care unit (ICU) has been shown to prevent errors, and pharmacist consultation has reduced drug costs. However, whether pharmacist participation in the ICU at ... | [
"Sulfasalazine in the treatment of spondylarthropathy. A randomized, multicenter, double-blind, placebo-controlled study.. OBJECTIVE To assess the efficacy and tolerability of sulfasalazine (SSZ) in the treatment of spondylarthropathy. METHODS We conducted a 6-month randomized, placebo-controlled, double-blind, mul... | 940 | 12258338 | [
"39892135",
"11254040",
"23073816",
"10582939"
] | scientific_claim_retrieval | scientific |
a3ae454d8a3a8c93c44fb0de38a7ca53 | mteb/scifact | Pseudogene PTENP1 encodes a transcript that regulates PTEN expression. | A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized that RNAs could possess a regulatory role that relies on the... | [
"Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis. Neonatal cholestasis is a potentially life-threatening condition requiring prompt diagnosis. Mutations in several different genes can cause progressive familial intrahepatic cholestasis, but known genes cannot acco... | 984 | 6828370 | [
"14479433",
"16364639",
"15928989",
"14864285"
] | scientific_claim_retrieval | scientific |
954722bc818f45f0fe189af2d1600378 | mteb/scifact | p16INK4A degradation is linked to an abnormal wound response caused by the microinvasive step of advanced Oral Potentially Malignant Lesions (OPMLs). | Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model. Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe a luciferase knockin mouse (p16(LUC)), which faithfully reports expression of p16(INK4a), a tumor suppressor and aging biomarker. Lifelong assessmen... | [
"G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator.. The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV in... | 1397 | 17717391 | [
"4387484",
"9614443",
"39443128",
"36310858"
] | scientific_claim_retrieval | scientific |
4b5b2a7330ab24696817689e3471be3e | mteb/scifact | Cancer-associated fibroblasts (CAFs) interact with cancer cells to mediate formation and activation of CAFs. | Microenvironmental regulation of tumor progression and metastasis. Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive th... | [
"miR-205 hinders the malignant interplay between prostate cancer cells and associated fibroblasts.. AIMS Tumor microenvironment is a strong determinant for the acquisition of metastatic potential of cancer cells. We have recently demonstrated that cancer-associated fibroblasts (CAFs) elicit a redox-dependent epithe... | 226 | 6944800 | [
"8702697",
"35993767",
"52925737",
"952111"
] | scientific_claim_retrieval | scientific |
0267d1b1428fef519b86c4cf4d5e61c7 | mteb/scifact | Lamins are associated with nuclear membrane structure maintenance. | Autophagy mediates degradation of nuclear lamina. Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic material... | [
"Cell death: the significance of apoptosis.. Publisher Summary The classification of cell death can be based on morphological or biochemical criteria or on the circumstances of its occurrence. Currently, irreversible structural alteration provides the only unequivocal evidence of death; biochemical indicators of ce... | 685 | 4452659 | [
"935034",
"11992632",
"22544171",
"4701662"
] | scientific_claim_retrieval | scientific |
2f5839aae2e837247b8ac67f29ebea6d | mteb/scifact | Physical activity level is associated with the difference in maximal oxygen consumption between black and white youth. | Relationship of physical activity and television watching with body weight and level of fatness among children: results from the Third National Health and Nutrition Examination Survey.. CONTEXT Physical inactivity contributes to weight gain in adults, but whether this relationship is true for children of different ethn... | [
"Consumption of added sugars from liquid but not solid sources predicts impaired glucose homeostasis and insulin resistance among youth at risk of obesity.. Little is known about longitudinal associations between added sugar consumption (solid and liquid sources) and glucose-insulin homeostasis among youth. Caucasi... | 946 | 8428935 | [
"11201004",
"52865789",
"39390206",
"41976370"
] | scientific_claim_retrieval | scientific |
89f3028875f18ef2c43a06805bd120ce | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Electrochemical Molecular Analysis Without Nucleic Acid Amplification. Electrochemical biosensors have revolutionized glucose monitoring but have not yet fulfilled their promise of a low cost, direct detection replacement for genetic amplification tests such as PCR [K. Kerman, M. Kobayashi, E. Tamiya, Recent trends in ... | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | p5jtwb3l | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
c3d9281b7018c9e0a3fdf40029f26e41 | mteb/scifact | Diabetic patients with acute coronary syndrome experience decreased short-term and long-term risk for bleeding events. | Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromes.. BACKGROUND Diabetes mellitus is a major risk factor for adverse outcomes after acute coronary syndromes (ACS). Because this disease may be associated with increased platelet aggregati... | [
"Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association.. Angiotensin converting enzyme (ACE) inhibitors are now one ... | 342 | 7873737 | [
"6157837",
"471921",
"308862",
"15648443"
] | scientific_claim_retrieval | scientific |
6371b9a29453b2581b3a5dd20dc54cdf | mteb/scifact | Pyridostatin encourages proliferation of homologous recombination - defective cells. | Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds. G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand ... | [
"Homologous recombination resolution defect in werner syndrome.. Werner syndrome (WRN) is an uncommon autosomal recessive disease whose phenotype includes features of premature aging, genetic instability, and an elevated risk of cancer. We used three different experimental strategies to show that WRN cellular pheno... | 994 | 16472469 | [
"6710699",
"25838286",
"19522248",
"10874408"
] | scientific_claim_retrieval | scientific |
460ae50299a211f40553bf10444aa560 | mteb/scifact | The morphology change from large white adipocytes to small brown adipocytes is a sign of increased energy expenditure potential in white adipose tissue. | Human ‘brite / beige’ adipocytes develop from capillary networks and their implantation improves metabolic homeostasis in mice. Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is also found outside classical brow... | [
"Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders. Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte... | 1236 | 17973161 | [
"14865329",
"1568684",
"29381091",
"18064113"
] | scientific_claim_retrieval | scientific |
60969bf5550ac248fde8041c8d45edbe | mteb/scifact | EGR2 is important to myelination of the peripheral nervous system. | The Transcription Factors Egr2 and Egr3 Are Essential for the Control of Inflammation and Antigen-Induced Proliferation of B and T Cells. Lymphocytes provide optimal responses against pathogens with minimal inflammatory pathology. However, the intrinsic mechanisms regulating these responses are unknown. Here, we report... | [
"Structural plasticity of the adult brain: how animal models help us understand brain changes in depression and systemic disorders related to depression. The brain interprets experiences and translates them into behavioral and physiological responses. Stressful events are those which are threatening or, at the very... | 364 | 1550937 | [
"6123521",
"2496002",
"15889329",
"29657303"
] | scientific_claim_retrieval | scientific |
b9837234aa1907cef486693e8d1b9712 | mteb/trec-covid | how does the coronavirus respond to changes in the weather | Large-scale Lassa fever outbreaks in Nigeria: quantifying the association between disease reproduction number and local rainfall. Lassa fever (LF) is increasingly recognised as an important rodent-borne viral haemorrhagic fever presenting a severe public health threat to sub-Saharan West Africa. In 2017–18, LF caused a... | [
"Network Clustering Revealed the Systemic Alterations of Mitochondrial Protein Expression. The mitochondrial protein repertoire varies depending on the cellular state. Protein component modifications caused by mitochondrial DNA (mtDNA) depletion are related to a wide range of human diseases; however, little is know... | 2 | 99lxmq4u | [
"9egy68c0",
"4cjlolp6",
"7o6htufh",
"upjhmfca"
] | biomedical_literature_retrieval | scientific |
27eba1c8459658cb598c9a788820cefe | mteb/scifact | Osteocytes have an essential role in G-CSF induced HSPC mobilization. | Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells.. The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic stem/progenitor cell (HSPC) migration out of the niche and into the circulation. Here, we demonstrate that osteocytes, the major cellular compone... | [
"Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.. A critical regulator of autophagy is the Class III PI3K Vps34 (also called PIK3C3). Although Vps34 is known to play an essential role in autophagy in yeast, its role in mammals remains elusive. To elucidate the physiologica... | 893 | 13509809 | [
"33507866",
"2774906",
"38899659",
"10795063"
] | scientific_claim_retrieval | scientific |
bc55fa2874b7837fc939952134a0726f | mteb/scifact | NR5A2 does not play a role in development of endometrial tissues. | Liver receptor homolog-1 is essential for pregnancy. Successful pregnancy requires coordination of an array of signals and factors from multiple tissues. One such element, liver receptor homolog-1 (Lrh-1), is an orphan nuclear receptor that regulates metabolism and hormone synthesis. It is strongly expressed in granulo... | [
"High-resolution mapping of open chromatin in the rice genome.. Gene expression is controlled by the complex interaction of transcription factors binding to promoters and other regulatory DNA elements. One common characteristic of the genomic regions associated with regulatory proteins is a pronounced sensitivity t... | 835 | 15928989 | [
"3514072",
"24998637",
"9076196",
"2443495"
] | scientific_claim_retrieval | scientific |
dd743806fb679f41532870ae63f9d34b | mteb/scifact | A breast cancer patient's capacity to metabolize tamoxifen influences treatment outcome. | Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen.. CONTEXT The growth inhibitory effect of tamoxifen, which is used for the treatment of hormone receptor-positive breast cancer, is mediated by its metabolites, 4-hydroxytamoxifen and endoxifen. The f... | [
"A review of psychosocial needs of breast-cancer patients and their relatives.. AIM To identify the psychosocial needs of breast-cancer patients and their relatives along with factors affecting these needs and to develop a tentative model to guide further research and need assessments in clinical practice. BACKGROU... | 30 | 24341590 | [
"23284774",
"24575065",
"195680777",
"13007205"
] | scientific_claim_retrieval | scientific |
a6d87f6461ffe72d135d35654e1381e1 | mteb/scifact | The peak incidence of fractures occurs in toddlers. | Incidence of childhood distal forearm fractures over 30 years: a population-based study.. CONTEXT The incidence of distal forearm fractures in children peaks around the time of the pubertal growth spurt, possibly because physical activity increases at the time of a transient deficit in cortical bone mass due to the inc... | [
"Sympathetic neural and cardiovascular responses during static handgrip exercise in women with a history of hypertensive pregnancy. Women with a history of hypertensive pregnancy are at greater risk for future cardiovascular events; however, the mechanisms for this increased risk are unknown. Evidence suggests that... | 1249 | 7209559 | [
"8596837",
"1102268",
"37731372",
"35621259"
] | scientific_claim_retrieval | scientific |
bde93911125ae5fd79320a2400491793 | mteb/scifact | Homozygous deletion of murine Sbds gene from osterix-expressing mesenchymal stem and progenitor cells (MPCs) induces oxidative stress. | Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.. Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system, but the underlying molecular mechanisms and relevance to human disease remain poo... | [
"Bone progenitor dysfunction induces myelodysplasia and secondary leukemia. Mesenchymal cells contribute to the 'stroma' of most normal and malignant tissues, with specific mesenchymal cells participating in the regulatory niches of stem cells. By examining how mesenchymal osteolineage cells modulate haematopoiesis... | 526 | 3863543 | [
"1617327",
"4366738",
"4335423",
"3756384"
] | scientific_claim_retrieval | scientific |
276908ce10f6ba4542215252063aa466 | mteb/scifact | B3-Galectin increases cell resistance to tyrosine kinase inhibitors (TKIs) by engaging the alternate KRAS-RalB signaling complex downstream of EGFR. | An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition. Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin αvβ3 serves as a marker of breast, lung and pancreatic carcinomas with stem-like properties that are hig... | [
"Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3'-kinase/Akt pathway signaling.. PURPOSE Tyrosine kinase (TK) inhibitors are emerging as a promising new approach to the treatme... | 154 | 4702639 | [
"34016944",
"711256",
"4820792",
"14819804"
] | scientific_claim_retrieval | scientific |
719aac1f7902f6dad0b9ea0327f9a7c0 | mteb/scifact | Increased flux of microbial products suppresses immune responses. | Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis.. Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colit... | [
"Regulation of the antimicrobial response by NLR proteins.. Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family of innate immune receptors that play a pivotal role in microbial sensing, leading to the initiation of antimicrobial immune responses. Dysregulation of the function ... | 610 | 40096222 | [
"4664540",
"5785219",
"29023309",
"21535641"
] | scientific_claim_retrieval | scientific |
1eda955e0ea54e01cf7ef6533b6c9fd9 | mteb/trec-covid | what types of rapid testing for Covid-19 have been developed? | Rapid respiratory panel testing: Impact of active antimicrobial stewardship | [
"WHAT CLINICIANS NEED TO KNOW ABOUT ANTIVIRAL DRUGS AND VIRAL RESISTANCE. During the last decade, significant advances have been made in the development and use of antiviral agents for the successful treatment of a number of viral infections.8, 51, 57 An expanding array of antiviral drugs are currently available fo... | 6 | 4b74nv18 | [
"6324190r",
"ukqvhzws",
"qyb8er14",
"2ygb80sc"
] | biomedical_literature_retrieval | scientific |
853768f250fac5c01d9daa026a6d7103 | mteb/scifact | Omnivores produce more trimethylamine N-oxide from dietary I-carnitine than vegans. | Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Intestinal microbiota metabolism of choline and phosphatidylcholine produces trimethylamine (TMA), which is further metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO). We demonstrate here that metaboli... | [
"Transmission of atherosclerosis susceptibility with gut microbial transplantation.. Recent studies indicate both clinical and mechanistic links between atherosclerotic heart disease and intestinal microbial metabolism of certain dietary nutrients producing trimethylamine N-oxide (TMAO). Here we test the hypothesis... | 883 | 14803797 | [
"33684572",
"15040589",
"39187170",
"11181416"
] | scientific_claim_retrieval | scientific |
640bd2b5410c44a49bb3e2c0080a1002 | mteb/scifact | The RANK-RANK-Ligand (RANKL) pathway is involved in the development of Aire-expressing medullary thymic epithelial cells (mTECs). | Rank Signaling Links the Development of Invariant γδ T Cell Progenitors and Aire+ Medullary Epithelium. The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embry... | [
"CD200R/CD200 Inhibits Osteoclastogenesis: New Mechanism of Osteoclast Control by Mesenchymal Stem Cells in Human. Bone homeostasis is maintained by the balance between bone-forming osteoblasts and bone-degrading osteoclasts. Osteoblasts have a mesenchymal origin whereas osteoclasts belong to the myeloid lineage. O... | 1181 | 301838 | [
"3531388",
"10162553",
"13989491",
"18414462"
] | scientific_claim_retrieval | scientific |
4494945ddd1a61ba27c769fff42d8a91 | mteb/trec-covid | what is the origin of COVID-19 | Deadly virus effortlessly hops species. Genetic engineering helps reveal origin of deadly 'flu | [
"The use of laparoscopy in abdominal emergencies. Background: The purpose of this article is to describe our experience using laparoscopy in the management of emergent and acute abdominal conditions. Methods: Between March 1997 and November 2001, 277 consecutive minimally invasive procedures were performed for vari... | 1 | 021q9884 | [
"o0syp1wb",
"hs2vni8z",
"35c6mak0",
"72s8wpla"
] | biomedical_literature_retrieval | scientific |
9ec793ab9c32deb4a2c54f95c5e58fcc | mteb/scifact | Lamins are found within the inner layer of the mitochondrial membrane of all cells. | Autophagy mediates degradation of nuclear lamina. Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic material... | [
"Human Macrophages Infected with a High Burden of ESAT-6-Expressing M. tuberculosis Undergo Caspase-1- and Cathepsin B-Independent Necrosis. Mycobacterium tuberculosis (Mtb) infects lung macrophages, which instead of killing the pathogen can be manipulated by the bacilli, creating an environment suitable for intrac... | 686 | 4452659 | [
"11837657",
"29641682",
"38025907",
"15593561"
] | scientific_claim_retrieval | scientific |
50f8f53989225f1ba5179e92b4b4369b | mteb/trec-covid | how long can the coronavirus live outside the body | Animal Virus Ecology and Evolution Are Shaped by the Virus Host-Body Infiltration and Colonization Pattern. The current classification of animal viruses is largely based on the virus molecular world. Less attention is given to why and how virus fitness results from the success of virus transmission. Virus transmission ... | [
"The impact of respiratory viruses on lung health after preterm birth. Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased... | 15 | 9xbu4hnq | [
"am4mdxok",
"dxdr6oan",
"49it5pha",
"mw7athol"
] | biomedical_literature_retrieval | scientific |
8cfc85409344a314b5ce9e8dbfebfbc9 | mteb/trec-covid | What new public datasets are available related to COVID-19? | Database resources of the National Center for Biotechnology Information. The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank(®) nucleic acid sequence database and the PubMed database of citations and abstracts for... | [
"The Social and Political Dimensions of the Ebola Response: Global Inequality, Climate Change, and Infectious Disease. The 2014 Ebola crisis has highlighted public-health vulnerabilities in Liberia, Sierra Leone, and Guinea—countries ravaged by extreme poverty, deforestation and mining-related disruption of livelih... | 35 | a564l6vs | [
"s5iavz3u",
"q70asnhh",
"pakh49dy",
"477dm0dy"
] | biomedical_literature_retrieval | scientific |
9941986be189ca2e69263b4b6ce1b0bd | mteb/scifact | Pseudoknots are not evolutionarily conserved in most eukaryotes. | Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes. RNases P and MRP are ribonucleoprotein complexes involved in tRNA and rRNA processing, respectively. The RNA subunits of these two enzymes are structurally related to each other and play an essential role in the enzymatic reaction... | [
"High prevalence of evolutionarily conserved and species-specific genomic aberrations in mouse pluripotent stem cells.. Mouse pluripotent stem cells (PSCs) are the best studied pluripotent system and are regarded as the \"gold standard\" to which human PSCs are compared. However, while the genomic integrity of huma... | 988 | 3033830 | [
"21479575",
"27900414",
"16686383",
"8759633"
] | scientific_claim_retrieval | scientific |
60e8bfa37bab9707abad92f11fed0c28 | mteb/scifact | Major antigen-induced signals from the T cell receptor and secondary signals from costimulatory receptors are required for T cell activation. | CD28 Costimulation: From Mechanism to Therapy.. Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure, and biochemistry of CD28 and its ligands. CD28 signals play a key role in many T ce... | [
"Stage-Specific and Differential Notch Dependency at the αβ and γδ T Lineage Bifurcation. Summary Signals transduced by Notch receptors are indispensable for T cell specification and differentiation of αβ T lineage cells. However, the role of Notch signals during αβ versus γδ T lineage decision remains controversia... | 749 | 13868795 | [
"85326624",
"8903143",
"1196631",
"40323148"
] | scientific_claim_retrieval | scientific |
4db4be6e7ed96a6133d8e7ad17ea7f7f | mteb/scifact | ATF4 is a general endoplasmic reticulum stress marker. | Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Endoplasmic reticulum (ER) stress causes pancreatic β-cell dysfunction and contributes to β-cell loss and the progression of type 2 diabetes. Wolfram syndrome 1 (WFS1) has been shown to be an importan... | [
"Involvement of ER Stress in Dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 Missense Mutations Shown by iPSC-Derived Oligodendrocytes. Pelizaeus-Merzbacher disease (PMD) is a form of X-linked leukodystrophy caused by mutations in the proteolipid protein 1 (PLP1) gene. Although PLP1 proteins with missense ... | 62 | 32587939 | [
"7482674",
"2727303",
"20904154",
"19138874"
] | scientific_claim_retrieval | scientific |
c960454bdf3187208d8752476791ea36 | mteb/scifact | Patients in stable partnerships progress from HIV to death at the same rate as patients not in partnerships. | Stable partnership and progression to AIDS or death in HIV infected patients receiving highly active antiretroviral therapy: Swiss HIV cohort study.. OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). D... | [
"Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis.. CONTEXT Clinicians and trialists have difficulty with identifying which patients are highest risk for cardiovascular events. Prior ischemic events, polyvascular disease, and diabetes mellitus h... | 925 | 17077004 | [
"16760369",
"28894097",
"38630735",
"14626540"
] | scientific_claim_retrieval | scientific |
c6c6b16864c1956e93b915844782d599 | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Serology in the Digital Age: Using Long Synthetic Peptides Created from Nucleic Acid Sequences as Antigens in Microarrays. Background: Antibodies to microbes, or to autoantigens, are important markers of disease. Antibody detection (serology) can reveal both past and recent infections. There is a great need for develop... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | i6jhquze | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
1ee1fd477789754d15484edfec76175c | mteb/scifact | C2 works synergistically with A-769662 to activate dephosphorylated AMPK. | Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding.. The metabolic stress-sensing enzyme AMP-activated protein kinase (AMPK) is responsible for regulating metabolism in response to energy supply and demand. Drugs that activate AMPK may be useful in the treatmen... | [
"Current knowledge and future directions of TLR and NOD signaling in sepsis. The incidence of sepsis is increasing over time, along with an increased risk of dying from the condition. Sepsis care costs billions annually in the United States. Death from sepsis is understood to be a complex process, driven by a lack ... | 196 | 19313533 | [
"17023584",
"21754541",
"3285059",
"10530014"
] | scientific_claim_retrieval | scientific |
4f53db71b1c6e3777d3f1c4b9c65c480 | mteb/trec-covid | how has lack of testing availability led to underreporting of true incidence of Covid-19? | Estimation of COVID-19 burden in Egypt | [
"Solidarity, vulnerability and mistrust: how context, information and government affect the lives of women in times of Zika. BACKGROUND: The public health response to Zika outbreak has mostly focused on epidemiological surveillance, vector control, and individual level preventative measures. This qualitative study ... | 8 | 60dfy8nz | [
"wlbja1gz",
"p2j4m552",
"lwvb6dxc",
"qjab20j6"
] | biomedical_literature_retrieval | scientific |
9be05ebb734d43404d3c8f958805e88f | mteb/scifact | aPKCz causes tumour suppression by affecting glutamine metabolism. | Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis. Tumor cells have high-energetic and anabolic needs and are known to adapt their metabolism to be able to survive and keep proliferating under conditions of nutrient stress. We show that PKCζ deficiency promotes the plasticity necessary... | [
"Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway. Cancer cells have metabolic dependencies that distinguish them from their normal counterparts. Among these dependencies is an increased use of the amino acid glutamine to fuel anabolic processes. Indeed, the spectrum of glutami... | 1383 | 17755060 | [
"3831884",
"3504761",
"9315213",
"4423401"
] | scientific_claim_retrieval | scientific |
ebc4b729af0d2358790f09ddafdf81a9 | mteb/scifact | Glial calcium waves influence seizures. | An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold. Seizures in focal epilepsies are sustained by a highly synchronous neuronal discharge that arises at restricted brain sites and subsequently spreads to large portions of the brain. Despite intense experimental research in this field, ... | [
"GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy.. BACKGROUND Dysfunction of gamma-aminobutyric acid (GABA) (B) receptors has been implicated in the pathogenesis of temporal lobe epilepsy (TLE). OBJECTIVE To evaluate the genetic contribution of cloned human GABA(B) receptors to TL... | 469 | 1410197 | [
"30534237",
"17101262",
"15889329",
"2547636"
] | scientific_claim_retrieval | scientific |
22b61ab39885765d64b3cf150c31e8fd | mteb/scifact | Lamins are found within the inner layer of the nuclear membrane of all cells. | Autophagy mediates degradation of nuclear lamina. Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic material... | [
"Reprogramming somatic cells towards pluripotency by cellular fusion.. Pluripotent cells arise within the inner cell mass (ICM) of mammals and have the potential to generate all cell types of the adult organism through a process of commitment and ordered differentiation. Despite many decades of investigation, the m... | 687 | 4452659 | [
"29641682",
"26374799",
"35004872",
"935034"
] | scientific_claim_retrieval | scientific |
f181fa2c986bb245a94b5abcda2cb821 | mteb/trec-covid | are there serological tests that detect antibodies to coronavirus? | Application of radioimmunological methods for checking the quality of class-specific antibodies against bovine and porcine immunoglobulins. Class-specific antibodies against bovine IgG1, IgG2, IgM and IgA and porcine IgG, IgM and IgA immunoglobulins were prepared. Their class specificity was assessed by two radioimmuno... | [
"Estimating human-to-human transmissibility of hepatitis A virus in an outbreak at an elementary school in China, 2011. Hepatitis A is caused by hepatitis A virus and occurs worldwide. Estimating the transmissibility, which is usually characterized by the basic reproductive number R(0), the mean number of secondary... | 7 | zsvdn8o3 | [
"3nk2ipyi",
"yiqdsf9z",
"h32821u0",
"2hchnlwb"
] | biomedical_literature_retrieval | scientific |
9765c3fb9051cea0c6e5deb467c44dfc | mteb/trec-covid | has social distancing had an impact on slowing the spread of COVID-19? | Quantifying social distancing arising from pandemic influenza. Local epidemic curves during the 1918–1919 influenza pandemic were often characterized by multiple epidemic waves. Identifying the underlying cause(s) of such waves may help manage future pandemics. We investigate the hypothesis that these waves were caused... | [
"Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.. The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, whi... | 10 | lusrcpns | [
"72s8wpla",
"37ojix5j",
"h51zr96k",
"w5fxen70"
] | biomedical_literature_retrieval | scientific |
55a302b8e05155a1fb56233e31c13a42 | mteb/scifact | Exercise increases cancer mortality rates among Chinese citizens. | Combined Impact of Lifestyle-Related Factors on Total and Cause-Specific Mortality among Chinese Women: Prospective Cohort Study. BACKGROUND Although cigarette smoking, excessive alcohol drinking, obesity, and several other well-studied unhealthy lifestyle-related factors each have been linked to the risk of multiple c... | [
"Cardiovascular diseases in Chinese, Malays, and Indians in Singapore. I. Differences in mortality.. STUDY OBJECTIVE The aim of the study was to analyse differences in mortality from the main cardiovascular diseases (ischaemic heart disease, hypertensive disease, and cerebrovascular disease) among Chinese, Malays, ... | 396 | 1456068 | [
"10209731",
"14700857",
"463533",
"42944505"
] | scientific_claim_retrieval | scientific |
e15557987e9471ace76ac4833d90f7d8 | mteb/scifact | Basophils promote disease development in patients with systemic lupus erythematosus (SLE). | BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS. In systemic lupus erythematosus (SLE), self-reactive antibodies can target the kidney (lupus nephritis), leading to functional failure and possible mortality. We report that activation of basophils by autoreactive IgE causes their ... | [
"Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. Objectives To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new r... | 172 | 12670680 | [
"27466734",
"28015516",
"44562904",
"15707049"
] | scientific_claim_retrieval | scientific |
7ccf8feef226b18736ec68acd53924eb | mteb/scifact | Hematopoietic Stem Cell purification reaches purity rates above 90%. | Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations. Heterogeneity within the self-renewal durability of adult hematopoietic stem cells (HSCs) challenges our understanding of the molecular framework underlying HSC function. Gene expression studies have been h... | [
"Hematopoietic stem cells and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing bcl-2.. Objective. Chemotherapeutic agents function by inducing apoptosis and their effectiveness depends on the balance of pro- and anti-apoptotic proteins in cells. Due to the compl... | 509 | 13980338 | [
"11900630",
"8724666",
"22530842",
"38899659"
] | scientific_claim_retrieval | scientific |
228f6cfc57fd04966f0133e032c63247 | mteb/scifact | Transcription rates in S. cerevisiae range between 7 and 12 kb/min. | Single-RNA counting reveals alternative modes of gene expression in yeast. Proper execution of transcriptional programs is a key requirement of gene expression regulation, demanding accurate control of timing and amplitude. How precisely the transcription machinery fulfills this task is not known. Using an in situ hybr... | [
"Spatial and temporal heterogeneity of Anopheles mosquitoes and Plasmodium falciparum transmission along the Kenyan coast.. The seasonal dynamics and spatial distributions of Anopheles mosquitoes and Plasmodium falciparum parasites were studied for one year at 30 villages in Malindi, Kilifi, and Kwale Districts alo... | 1315 | 16237005 | [
"8373753",
"18537148",
"323335",
"3462075"
] | scientific_claim_retrieval | scientific |
5409f980260698a075fa12ee27331594 | mteb/scifact | Integrating classroom-based collaborative learning with Web-based collaborative learning offers the best class performance. | Computer assisted learning in undergraduate medical education.. It is becoming “a truth universally acknowledged” that the education of undergraduate medical students will be enhanced through the use of computer assisted learning. Access to the wide range of online options illustrated in the figure must surely make lea... | [
"Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study.. OBJECTIVE To determine whether exposure to low doses of ionising radiation in infancy affects cognitive function in adulthood. DESIGN Population based cohort study. SETTING Sweden. PARTI... | 650 | 12789595 | [
"15678772",
"1542437",
"6985854",
"1191830"
] | scientific_claim_retrieval | scientific |
80cc50a212fc9f5e92dcbbc4181ccd60 | mteb/scifact | Neutrophil extracellular trap (NET) antigens may contain the targeted autoantigens PR3 and MPO. | Netting neutrophils in autoimmune small-vessel vasculitis. Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and... | [
"A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus.. Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules that constitute a newly described killing mechanism in innate immune defense. Previous publications reported t... | 844 | 17741440 | [
"43054703",
"36089763",
"28015516",
"2236768"
] | scientific_claim_retrieval | scientific |
6fbd35d151131c149cee5d6d5e8cbf31 | mteb/scifact | The first MBT repeat of the four malignant brain tumor (4MBT) domain of Drosophila's Sfmbt and of the orthologous mammalian L3MBTL2 is required for the interaction with the spacer region of Drosophila's Pleiohomeotic (Pho) or its human ortholog YY1. | The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.. L3mbtl2 has been implicated in transcriptional repression and chromatin compaction but its biological function has not been defined. Here we show that disruption of L3mbtl2 re... | [
"Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.. Insulin-regulated aminopeptidase (IRAP or oxytocinase) is a membrane-bound zinc-metallopeptidase that cleaves neuroactive peptides in the brain and produces memory enhancing effects when inhibited. We have determined... | 1218 | 15635366 | [
"25483562",
"5273056",
"8208212",
"22191759"
] | scientific_claim_retrieval | scientific |
4267f6331fc967e6397ad180210f2dc7 | mteb/scifact | MafA ubiquitination decreases the recruitment of coavtivator P/CAF by MafA. | GSK-3-mediated phosphorylation enhances Maf-transforming activity.. The Maf oncoproteins are b-Zip transcription factors of the AP-1 superfamily. They are involved in developmental, metabolic, and tumorigenic processes. Maf proteins are overexpressed in about 50% of human multiple myelomas. Here, we show that Maf-trans... | [
"A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show that CAFs exert a physical force on cancer cells that enables their collective invasion. Force transmission is med... | 747 | 11291348 | [
"3727986",
"2266471",
"18084826",
"14461101"
] | scientific_claim_retrieval | scientific |
dd60b5fbb859fb1aeae54c7623feb5ab | mteb/trec-covid | How much impact do masks have on preventing the spread of the COVID-19? | The Effect of Mask Use on the Spread of Influenza During a Pandemic. Face masks have traditionally been used in general infection control, but their efficacy at the population level in preventing transmission of influenza viruses has not been studied in detail. Data from published clinical studies indicate that the inf... | [
"Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques. The experimental infection of rhesus macaques (rh) with simian immunodeficiency virus (SIV) is an important model for human immunodeficiency virus (HIV) infection of humans. The interferon-induced transmembrane protein 3 (IFIT... | 44 | mfb2or98 | [
"beqvgdjo",
"y09mca1m",
"0quwwawp",
"rdnrbwkq"
] | biomedical_literature_retrieval | scientific |
914ce9289122e1dffbc4c2e8b7868f4f | mteb/scifact | There was an estimated 30 million cases of pneumonia in young children worldwide in 2010. | Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. BACKGROUND The annual number of hospital admissions and in-hospital deaths due to severe acute lower respiratory infections (ALRI) in young children worldwide is unknown. We ... | [
"ADHD medications and risk of serious cardiovascular events in young and middle-aged adults.. CONTEXT More than 1.5 million US adults use stimulants and other medications labeled for treatment of attention-deficit/hyperactivity disorder (ADHD). These agents can increase heart rate and blood pressure, raising concer... | 1297 | 9167230 | [
"10984005",
"841371",
"17454301",
"44624045"
] | scientific_claim_retrieval | scientific |
fc20d4192f1199a40683acdd8c9edd6f | mteb/trec-covid | are there any clinical trials available for the coronavirus | Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis. BACKGROUND: Our recent meta-analysis indicated that vitamin C may shorten the length of ICU stay and the duration of mechanical ventilation. Here we analyze modification of the vitamin C effect on ventila... | [
"Diagnosis and Management of Tuberculous Pericarditis: What Is New?. PURPOSE OF REVIEW: This review provides an update on the immunopathogenesis of tuberculous pericarditis (TBP), investigations to confirm tuberculous etiology, the limitations of anti-tuberculous therapy (ATT), and recent efficacy trials. RECENT FI... | 17 | rm0zbgfm | [
"pakh49dy",
"4d33eg4e",
"3fdptled",
"aqv7xhng"
] | biomedical_literature_retrieval | scientific |
a6f629e08e97841c3973bcb071d952ff | mteb/scifact | Induction of urokinase receptor signaling in podocytes causes foot process effacement and proteinuria. | Modification of kidney barrier function by the urokinase receptor. Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. Here we show that induction of ur... | [
"Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis. Tumor angiogenesis is an essential process for supplying rapidly growing malignant tissues with essential nutrients and oxygen. An angiogenic switch allows tumor cells to survive and grow, and provides them access to vasculature resu... | 626 | 16355392 | [
"13070316",
"5836",
"5500086",
"9614443"
] | scientific_claim_retrieval | scientific |
16a010d1920800f9fc8e1149f1d4230e | mteb/scifact | Adult tissue-resident macrophages are seeded before birth. | Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.. Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence for labor division indicates that manipulati... | [
"Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases.. Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whe... | 86 | 7521113 | [
"16863359",
"12827098",
"22973574",
"2604063"
] | scientific_claim_retrieval | scientific |
ed17826869b3363247e4efad7b64a609 | mteb/scifact | Glycan adaptation is rarely observed in the B-cell repertoire. | Broad neutralization coverage of HIV by multiple highly potent antibodies. Broadly neutralizing antibodies against highly variable viral pathogens are much sought after to treat or protect against global circulating viruses. Here we probed the neutralizing antibody repertoires of four human immunodeficiency virus (HIV)... | [
"Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. De-regulation of the wingless and integration site growth factor (WNT) signaling pathway via mutations in APC and Axin, proteins that target β-catenin for destruction, have been linked to... | 474 | 4373433 | [
"17648235",
"20645538",
"13481880",
"21392223"
] | scientific_claim_retrieval | scientific |
00ce2a9504144cf0e19b9ce01588c149 | mteb/trec-covid | How does the coronavirus differ from seasonal flu? | Influenza. Influenza continues to baffle humans by its constantly changing nature. The twenty-first century has witnessed considerable advances in the understanding of the influenza viral pathogenesis, its synergy with bacterial infections and diagnostic methods. However, challenges continue: to find a less expensive a... | [
"Anticipating the Species Jump: Surveillance for Emerging Viral Threats. Zoonotic disease surveillance is typically triggered after animal pathogens have already infected humans. Are there ways to identify high-risk viruses before they emerge in humans? If so, then how and where can identifications be made and by w... | 31 | ews6n5qc | [
"g7pigmgc",
"ugc7ce21",
"5opiip58",
"sil8te5t"
] | biomedical_literature_retrieval | scientific |
375c22f12e1aec2c0ef229bd7777a059 | mteb/scifact | Sepsis related mortality has remained stable between 2009-2014. | Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014. Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected b... | [
"Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila.. Dendrite shape is considered a defining component of neuronal function. Yet, the mechanisms specifying diverse dendritic morphologies, and the extent to which their function depends ... | 1072 | 4824840 | [
"36111909",
"22194407",
"1831916",
"8148122"
] | scientific_claim_retrieval | scientific |
386872e2c2f7ad7b41f83f8a51589590 | mteb/scifact | Commelina yellow mottle virus (ComYMV) has three typical badnavirus ORFs, capable of encoding proteins 23, 15, and 216 kD. | Properties of Commelina yellow mottle virus's complete DNA sequence, genomic discontinuities and transcript suggest that it is a pararetrovirus.. The non-enveloped bacilliform viruses are the second group of plant viruses known to possess a genome consisting of circular double-stranded DNA. We have characterized the vi... | [
"Differential distribution of IL28B.rs12979860 single-nucleotide polymorphism among Egyptian healthcare workers with and without a hepatitis C virus-specific cellular immune response. The CC genotype of the interleukin (IL)-28B.rs12979860 gene has been associated with spontaneous hepatitis C virus (HCV) clearance a... | 277 | 14376683 | [
"991139",
"29107180",
"8082528",
"83667891"
] | scientific_claim_retrieval | scientific |
6ab8b75b335719887464d47db4562a44 | mteb/scifact | Sequence conservation in gene regulatory regions between species is a high-accuracy predictor of conserved functionality. | Enhancer Evolution across 20 Mammalian Species. The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian specie... | [
"Identification and characterization of a widely expressed form of adenylyl cyclase.. A novel mammalian adenylyl cyclase was identified by reverse transcription-polymerase chain reaction amplification using degenerate primers based on a conserved region of previously described adenylyl cyclases (Premont, R. T. (199... | 1074 | 14658685 | [
"34846352",
"10766688",
"8352137",
"9420732"
] | scientific_claim_retrieval | scientific |
cfffe1ee02dea8d90cf46b6a361f86a0 | mteb/scifact | Risk-adjusted mortality rates are similar in teaching and non-teaching hospitals. | Patient Outcomes with Teaching Versus Nonteaching Healthcare: A Systematic Review. Background Extensive debate exists in the healthcare community over whether outcomes of medical care at teaching hospitals and other healthcare units are better or worse than those at the respective nonteaching ones. Thus, our goal was t... | [
"Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry.. BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care... | 1055 | 13906581 | [
"5884524",
"13230773",
"17914395",
"3776162"
] | scientific_claim_retrieval | scientific |
9a6dd3742aee0184b7634a1fb23af75d | mteb/scifact | Bone marrow cells don't contribute to adult macrophage compartments. | Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.. Despite accumulating evidence suggesting local self-maintenance of tissue macrophages in the steady state, the dogma remains that tissue macrophages derive from monocytes. Using parabiosis and ... | [
"Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts.. Activated T cells secrete multiple osteoclastogenic cytokines which play a major role in the bone destruction associated with rheumatoid arthritis. While the role of T cells in osteoclastogenesis has re... | 184 | 12827098 | [
"43619625",
"3462075",
"39851630",
"1122198"
] | scientific_claim_retrieval | scientific |
d2a0b985ffc51259c997a4580ea92f48 | mteb/scifact | Intra-cerebroventricular infusion of amyloid-β oligomers reduces expression of fibronectin type-III domain-containing protein 5 mRNA in mice hippocampi. | Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models. Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-boun... | [
"Human CYP3A4 and murine Cyp3A11 are regulated by equol and genistein via the pregnane X receptor in a species-specific manner.. Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. PXR activation by endogenous and ex... | 655 | 57574395 | [
"20659283",
"25510546",
"4323449",
"30351165"
] | scientific_claim_retrieval | scientific |
086f31e16f556da88b633dcce041cd04 | mteb/scifact | Systemic lupus erythematosus is a risk factor for cardiovascular disease. | Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. Objectives To develop and validate updated QRISK3 prediction algorithms to estimate the 10 year risk of cardiovascular disease in women and men accounting for potential new risk f... | [
"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune complexes ... | 1127 | 27466734 | [
"1049501",
"28015516",
"5612738",
"24396137"
] | scientific_claim_retrieval | scientific |
5a11a0313397ec9b3888a88df0604d1b | mteb/scifact | A deficiency of vitamin B6 decreases blood levels of homocysteine. | Randomized trial of folic acid supplementation and serum homocysteine levels.. BACKGROUND Lowering serum homocysteine levels with folic acid is expected to reduce mortality from ischemic heart disease. Homocysteine reduction is known to be maximal at a folic acid dosage of 1 mg/d, but the effect of lower doses (relevan... | [
"Preventing coronary heart disease: B vitamins and homocysteine.. The list of preventable and reversible risk factors for atherosclerotic cardiovascular disease continues to grow. Cigarette smoking, high blood pressure, physical inactivity, elevated cholesterol, underlying lipoprotein abnormalities, lipoprotein(a),... | 37 | 11705328 | [
"16252863",
"33409100",
"19799455",
"3034412"
] | scientific_claim_retrieval | scientific |
78c0fc6f5fc1cd22667ea0f6d9f74349 | mteb/trec-covid | has social distancing had an impact on slowing the spread of COVID-19? | Local risk perception enhances epidemic control. As infectious disease outbreaks emerge, public health agencies often enact vaccination and social distancing measures to slow transmission. Their success depends on not only strategies and resources, but also public adherence. Individual willingness to take precautions m... | [
"Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.. The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, whi... | 10 | 9c0zrp7p | [
"72s8wpla",
"37ojix5j",
"h51zr96k",
"w5fxen70"
] | biomedical_literature_retrieval | scientific |
bffa0d3cec26987f6dafaba96691e100 | mteb/scifact | Walking in traffic areas in London did not improve lung function in elderly adults. | Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study. BACKGROUND Long-term exposure to pollution can lead to... | [
"Social variations in access to hospital care for patients with colorectal, breast, and lung cancer between 1999 and 2006: retrospective analysis of hospital episode statistics. OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by... | 1372 | 21003930 | [
"16390264",
"2820454",
"2825340",
"21956124"
] | scientific_claim_retrieval | scientific |
e74edf7c643b01ce4e99d7b9553dd5f1 | mteb/scifact | The tissue surrounding the granuloma in an immune cell induces an anti-inflammatory immune response. | Inflammatory signaling in human Tuberculosis granulomas is spatially organized. Granulomas are the pathological hallmark of tuberculosis (TB). However, their function and mechanisms of formation remain poorly understood. To understand the role of granulomas in TB, we analyzed the proteomes of granulomas from subjects w... | [
"Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung.. The human tuberculous granuloma provides the morphological basis for local immune processes central to the outcome of tuberculosis. Because of the scarcity of information in human patien... | 1276 | 3475317 | [
"34615397",
"44562221",
"44724517",
"15435343"
] | scientific_claim_retrieval | scientific |
ada5487a871e6b96aba95e55488cf6b9 | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | The role of masks and respirator protection against SARS-CoV-2 | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | 8w0cquhn | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
f2eea109054f7a10f0c34dcf3563146f | mteb/scifact | Mitochondria play a major role in apoptosis. | Mitochondria: Dynamic Organelles in Disease, Aging, and Development. Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitochondria... | [
"MicroRNA Response of Primary Human Macrophages to Arcobacter Butzleri Infection. The role of microRNAs (miRNAs) in infectious diseases is becoming more and more apparent, and the use of miRNAs as a diagnostic tool and their therapeutic application has become the major focus of investigation. The aim of this study ... | 795 | 8551160 | [
"14362780",
"25251625",
"27693891",
"29367554"
] | scientific_claim_retrieval | scientific |
b0cc9e2739655e1545eac58b838f857f | mteb/scifact | TNFAIP3 is a tumor enhancer in glioblastoma. | Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth. Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be useful therapeutic targets. We d... | [
"EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme.. Significant endeavor has been applied to identify functional therapeutic targets in glioblastoma (GBM) to halt the growth of this aggressive cancer. We show that the receptor tyrosine kinase EphA3 is frequently overexpressed in... | 1136 | 33370 | [
"5123516",
"195689757",
"9669099",
"15215393"
] | scientific_claim_retrieval | scientific |
9db114266753e8bf560fd5b2d1dd2b5c | mteb/trec-covid | has social distancing had an impact on slowing the spread of COVID-19? | Pandemic influenza in Papua New Guinea: a modelling study comparison with pandemic spread in a developed country. OBJECTIVES: The possible occurrence of a highly pathogenic influenza strain is of concern to health authorities worldwide. It is known that during past influenza pandemics developing countries have experien... | [
"Practical Considerations When Performing Neurodiagnostic Studies on Patients with COVID-19 and Other Highly Virulent Diseases.. The coronavirus disease 2019, SARS-COV-2 (the cause of COVID-19), has led to a worldwide shortage of personal protective equipment (PPE) and an increased stress on hospital resources, whi... | 10 | y01w04lc | [
"72s8wpla",
"37ojix5j",
"h51zr96k",
"w5fxen70"
] | biomedical_literature_retrieval | scientific |
9ab0eebc91ad874b0a55b11a680d01cd | mteb/trec-covid | what are the best masks for preventing infection by Covid-19? | Transmission of Influenza A in a Student Office Based on Realistic Person-to-Person Contact and Surface Touch Behaviour. Influenza A viruses result in the deaths of hundreds of thousands of individuals worldwide each year. In this study, influenza A transmission in a graduate student office is simulated via long-range ... | [
"Modeling Detection of HIV in Cuba. A nonlinear compartmental model is developed for the HIV detection system in Cuba with different types of detections, some random and others non-random. We analyze the dynamics of this system, compute the reproduction numbers, and use the data from the Cuban HIV/AIDS epidemic bet... | 18 | 6yu02snn | [
"5bwsb265",
"3okytwd8",
"jk7cn1p3",
"pyrfgggz"
] | biomedical_literature_retrieval | scientific |
3b59e84d4d70b3c6d8c33f11f4602370 | mteb/scifact | The US health care system can save up to $5 billion if 7% of patients waiting for kidney transplants participate in the optimized national kidney paired donation program. | Kidney paired donation and optimizing the use of live donor organs.. CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant. Kidney paired donation (KPD) offers incompatible donor/recipient pairs the opportunity to match for co... | [
"Successful three-way kidney paired donation with cross-country live donor allograft transport.. Providing transplantation opportunities for patients with incompatible live donors through kidney paired donation (KPD) is seen as one of the important strategies for easing the crisis in organ availability. It has been... | 1184 | 16737210 | [
"21859699",
"11230569",
"45461275",
"73323408"
] | scientific_claim_retrieval | scientific |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.