message stringlengths 3 12.9k | message_type stringclasses 3
values | message_id int64 0 2 | conversation_id int64 54.3k 898k | cluster float64 91 91 | __index_level_0__ int64 162k 2.69M |
|---|---|---|---|---|---|
Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome | output | 1 | 79,760 | 91 | 238,871 |
Severe cases of COVID-19 infection, often leading to death, have been associated with variants of acute respiratory distress syndrome (ARDS). Cell therapy with mesenchymal stromal cells (MSCs) is a potential treatment for COVID-19 ARDS based on preclinical and clinical studies supporting the concept that MSCs modulate ... | input | 2 | 79,760 | 91 | 238,872 |
Please summerize the given abstract to a title | instruction | 0 | 79,849 | 91 | 239,137 |
The Use of Standardized Brazilian Green Propolis Extract (EPP-AF) as an Adjunct Treatment for Hospitalized COVID-19 Patients (BeeCovid2): A Structured Summary of a Study Protocol for a Randomized Controlled Trial | output | 1 | 79,849 | 91 | 239,138 |
Background: The 2019 coronavirus disease (COVID-19) pandemic continues to spread and affects large numbers of people with unprecedented impacts. To date, there is no consensus on a specific treatment. Experimental evidence has already been obtained for use of the standardized extract of Brazilian green propolis (EPP-AF... | input | 2 | 79,849 | 91 | 239,139 |
Please summerize the given abstract to a title | instruction | 0 | 80,029 | 91 | 239,677 |
Ivermectin: a mini-review | output | 1 | 80,029 | 91 | 239,678 |
Introduction: Avermectins are common antiparasitic drugs, derived from Streptomyces bacteria that exhibit activity against arthropods and nematodes. Ivermectin, an avermectin derivative, is used as a treatment for parasitic infections in humans and domesticated animals.Discussion: Ivermectin's mechanism of action invol... | input | 2 | 80,029 | 91 | 239,679 |
Please summerize the given abstract to a title | instruction | 0 | 80,161 | 91 | 240,073 |
Tocilizumab for the Treatment of COVID-19-Induced Cytokine Storm and Acute Respiratory Distress Syndrome: A Case Series From a Rural Level 1 Trauma Center in Western Pennsylvania | output | 1 | 80,161 | 91 | 240,074 |
An outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2, initially in December 2019 at Wuhan, China, subsequently spread around the world. We describe a case series of COVID-19 patients treated at our academic medical center with focus on cytokine storm and potential... | input | 2 | 80,161 | 91 | 240,075 |
Please summerize the given abstract to a title | instruction | 0 | 80,246 | 91 | 240,328 |
Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak. | output | 1 | 80,246 | 91 | 240,329 |
BACKGROUND The outcome is reported of a prospective uncontrolled study based on a stepwise treatment protocol during an outbreak of severe acute respiratory syndrome (SARS) in Hong Kong. METHOD One hundred and thirty eight patients were treated with broad spectrum antibiotics, a combination of ribavirin and low dose co... | input | 2 | 80,246 | 91 | 240,330 |
Please summerize the given abstract to a title | instruction | 0 | 80,267 | 91 | 240,391 |
Appropriate use of tocilizumab in COVID-19 infection | output | 1 | 80,267 | 91 | 240,392 |
OBJECTIVE: This study aimed to describe the effectiveness and optimum use of tocilizumab (TCZ) treatment by the support of clinical, laboratory and radiologic observations. METHODS: All patients were followed up in the hospital with daily interleukin-6 (IL-6), C-reactive protein (CRP), ferritin, d-dimer, full blood cou... | input | 2 | 80,267 | 91 | 240,393 |
Please summerize the given abstract to a title | instruction | 0 | 80,282 | 91 | 240,436 |
Treatment strategies for postviral olfactory dysfunction: A systematic review | output | 1 | 80,282 | 91 | 240,437 |
Background: The coronavirus disease 2019 (COVID-19) pandemic has been associated with a dramatic increase in postviral olfactory dysfunction (PVOD) among patients who are infected. A contemporary evidence-based review of current treatment options for PVOD is both timely and relevant to improve patient care. Objective: ... | input | 2 | 80,282 | 91 | 240,438 |
Please summerize the given abstract to a title | instruction | 0 | 80,288 | 91 | 240,454 |
COVID-19 in IBD: The experience of a single tertiary IBD center | output | 1 | 80,288 | 91 | 240,455 |
BACKGROUND: Italy has been one of the most affected countries in the world by COVID-19. There has been increasing concern regarding the impact of COVID-19 on patients with inflammatory bowel disease (IBD), particularly in patients treated with immunosuppressants or biologics. The aim of our study is to understand the i... | input | 2 | 80,288 | 91 | 240,456 |
Please summerize the given abstract to a title | instruction | 0 | 80,318 | 91 | 240,544 |
Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series | output | 1 | 80,318 | 91 | 240,545 |
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a fatal complication of coronavirus disease 2019 (COVID-19). There are a few reports of allogeneic human mesenchymal stem cells (MSCs) as a potential treatment for ARDS. In this phase 1 clinical trial, we present the safety, feasibility, and tolerability of the ... | input | 2 | 80,318 | 91 | 240,546 |
Please summerize the given abstract to a title | instruction | 0 | 80,495 | 91 | 241,075 |
Efficacy and Effect of Inhaled Adenosine Treatment in Hospitalized COVID-19 Patients | output | 1 | 80,495 | 91 | 241,076 |
Lack of specific antiviral treatment for COVID-19 has resulted in long hospitalizations and high mortality rate. By harnessing the regulatory effects of adenosine on inflammatory mediators, we have instituted a new therapeutic treatment with inhaled adenosine in COVID-19 patients, with the aim of reducing inflammation,... | input | 2 | 80,495 | 91 | 241,077 |
Please summerize the given abstract to a title | instruction | 0 | 80,831 | 91 | 242,083 |
Role of Statins in Coronavirus-Related Disease (COVID-19): A Retrospective Cohort Study in Northern Italy | output | 1 | 80,831 | 91 | 242,084 |
INTRODUCTION: The outbreak by SARS-CoV-2 has rapidly spread worldwide. The need for specific treatments to adequately stop the inflammatory response and its sequelae is day by day more urgent and many therapeutic strategies were performed since COVID-19 burst in the last months. Statins were thought to be effective aga... | input | 2 | 80,831 | 91 | 242,085 |
Please summerize the given abstract to a title | instruction | 0 | 80,835 | 91 | 242,095 |
Role of Mycobacterium w for the Treatment of COVID-19: An Observational Study. | output | 1 | 80,835 | 91 | 242,096 |
Background COVID-19 has taken a big toll on the world in terms of morbidity and mortality. The disease may progress in some of the patients leading to trigger of "cytokine storm" which is shown to be associated with adverse outcomes. Heat killed Mycobacterium w (Mw) is a known immunomodulator which is approved for the ... | input | 2 | 80,835 | 91 | 242,097 |
Please summerize the given abstract to a title | instruction | 0 | 80,915 | 91 | 242,335 |
In patients hospitalized with COVID-19, adding azithromycin to usual care did not reduce 28-d mortality. | output | 1 | 80,915 | 91 | 242,336 |
SOURCE CITATION RECOVERY Collaborative Group. Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021;397:605-12. 33545096. | input | 2 | 80,915 | 91 | 242,337 |
Please summerize the given abstract to a title | instruction | 0 | 81,008 | 91 | 242,614 |
Observational Study of the Efficiency of Treatments in Patients Hospitalized with Covid-19 in Madrid | output | 1 | 81,008 | 91 | 242,615 |
Background Many different treatments were heavily administered to patients with COVID-19 during the peak of the pandemic in Madrid without robust evidence supporting them. Methods We examined the association between sixteen treatments in four groups (steroids, antivirals, antibiotics and immunomodulators) and intubatio... | input | 2 | 81,008 | 91 | 242,616 |
Please summerize the given abstract to a title | instruction | 0 | 81,047 | 91 | 242,731 |
P.0404 Rapid antidepressant response to first-line selective serotonin reuptake inhibitors in post-COVID-19 depression | output | 1 | 81,047 | 91 | 242,732 |
Introduction: Depression was reported in 30–40% of patients at one, three, and six months following COVID-19 [1]. The host immune response to SARS-CoV-2 infection and related severe systemic inflammation seems to be the main mechanism contributing to the development of post-COVID depression. Emerging literature suggest... | input | 2 | 81,047 | 91 | 242,733 |
Please summerize the given abstract to a title | instruction | 0 | 81,092 | 91 | 242,866 |
Infectious diseases | output | 1 | 81,092 | 91 | 242,867 |
What's new in infectious diseases in 2020 ? This year has been marked by the COVID-19 pandemic, prompting a review of the current knowledge on SARS-CoV-2 and its management in this article The results of the Swiss project « PIRATE » indicate non-inferiority between CRP-guided antibiotic durations or fixed 7-day duratio... | input | 2 | 81,092 | 91 | 242,868 |
Please summerize the given abstract to a title | instruction | 0 | 81,276 | 91 | 243,418 |
Efficacy and Safety of Sofosbuvir/Daclatasvir in the Treatment of COVID-19: A Randomized, Controlled Study | output | 1 | 81,276 | 91 | 243,419 |
BACKGROUND: Data from molecular docking, in-vitro experiments and 2 published small clinical studies suggested a potential therapeutic benefit for the anti-hepatitis C drugs, sofosbuvir (SOF) and daclatasvir (DCV), to repurpose for the treatment of COVID-19. We planned this study to evaluate efficacy and safety of dual... | input | 2 | 81,276 | 91 | 243,420 |
Please summerize the given abstract to a title | instruction | 0 | 81,361 | 91 | 243,673 |
Therapeutic Plasma Exchange is Safe and Efficacious in Normalizing Increased Plasma Viscosity Associated with COVID-19 | output | 1 | 81,361 | 91 | 243,674 |
BACKGROUND: COVID-19 associated hyperviscosity is a potential driver for the increased rates of thrombotic complications and multi-organ failure associated with severe COVID-19. Limited experience suggests a promising role for Therapeutic Plasma Exchange (TPE) in COVID-19 management based on the hypothesis that clinica... | input | 2 | 81,361 | 91 | 243,675 |
Please summerize the given abstract to a title | instruction | 0 | 81,500 | 91 | 244,090 |
Convalescent plasma in COVID-19: Does use case matter? | output | 1 | 81,500 | 91 | 244,091 |
A randomized controlled trial of convalescent plasma in severe COVID-19 shows no benefits Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of individuals worldwide One of the most severe manifestations of COVID-19 is severe pne... | input | 2 | 81,500 | 91 | 244,092 |
Please summerize the given abstract to a title | instruction | 0 | 81,588 | 91 | 244,354 |
Case series of six kidney transplanted patients with COVID-19 pneumonia treated with tocilizumab | output | 1 | 81,588 | 91 | 244,355 |
Few reports described the outcome of kidney transplanted patients (KTs) affected by COVID-19 treated with interleukin-6 receptor inhibitor Tocilizumab (TCZ). We report our case series of 6 KTs with COVID-19 pneumonia who received TCZ: all were of male gender, with a mean age of 55.5±8.4 years, a median time from transp... | input | 2 | 81,588 | 91 | 244,356 |
Please summerize the given abstract to a title | instruction | 0 | 81,663 | 91 | 244,579 |
A HOME-TREATMENT ALGORITHM BASED ON ANTI-INFLAMMATORY DRUGS TO PREVENT HOSPITALIZATION OF PATIENTS WITH EARLY COVID-19: A MATCHED-COHORT STUDY (COVER 2) | output | 1 | 81,663 | 91 | 244,580 |
Background and Aim: While considerable success has been achieved in the management of patients hospitalized with severe coronavirus disease 2019 (COVID-19), far less progress has been made with early outpatient treatment. We assessed whether the implementation of a home treatment algorithm, designed based upon on a pat... | input | 2 | 81,663 | 91 | 244,581 |
Please summerize the given abstract to a title | instruction | 0 | 81,688 | 91 | 244,654 |
Beneficial effect of Arbidol in the management of COVID-19 infection | output | 1 | 81,688 | 91 | 244,655 |
This study analyzed the effect of Arbidol, a broad-spectrum antiviral compound, on the outcomes of COVID-19 patients. Records of 252 COVID-19 patients were retrospectively analyzed from February 13 to February 29, 2020 in 4 inpatient wards in the Cancer Center, Union Hospital, Tongji Medical College of Huazhong Univers... | input | 2 | 81,688 | 91 | 244,656 |
Please summerize the given abstract to a title | instruction | 0 | 81,719 | 91 | 244,747 |
In nonhospitalized, unvaccinated adults with COVID-19, molnupiravir reduced hospitalization or death at 29 d. | output | 1 | 81,719 | 91 | 244,748 |
SOURCE CITATION Jayk Bernal A, Gomes da Silva MM, Musungaie DB, et al. Molnupiravir for oral treatment of Covid-19 in nonhospitalized patients. N Engl J Med. 2022;386:509-20. 34914868. | input | 2 | 81,719 | 91 | 244,749 |
Please summerize the given abstract to a title | instruction | 0 | 81,790 | 91 | 244,960 |
CLL-370: The Prolonged Positivity of SARS-CoV-2 RNA in Chronic Lymphocytic Leukemia Patients | output | 1 | 81,790 | 91 | 244,961 |
Context Coronavirus disease 2019 (COVID-19) is a highly infectious disease. A small proportion of COVID patients are positive for SARS-CoV-2 for long time. We report a COVID-19 patient with prolonged presence of SARS-CoV-2 RNA. Objective In this study we evaluate the unexpected evolution of patients with CLL diagnosed ... | input | 2 | 81,790 | 91 | 244,962 |
Please summerize the given abstract to a title | instruction | 0 | 81,905 | 91 | 245,305 |
The Anti-Coronavirus Therapy (ACT) trials: design, baseline characteristics, and challenges. | output | 1 | 81,905 | 91 | 245,306 |
BACKGROUND: Effective treatments for COVID-19 are urgently needed but conducting randomized trials during the pandemic has been challenging. METHODS: The Anti-Coronavirus Therapy (ACT) trials are parallel factorial international trials that aimed to enroll 3,500 outpatients and 2,500 inpatients with symptomatic COVID-1... | input | 2 | 81,905 | 91 | 245,307 |
Please summerize the given abstract to a title | instruction | 0 | 81,908 | 91 | 245,314 |
Outcomes of a COVID‐19 recovery program for patients hospitalized with SARS‐CoV‐2 infection in New York City: A prospective cohort study | output | 1 | 81,908 | 91 | 245,315 |
BACKGROUND: In the spring of 2020, New York City was an epicenter of coronavirus disease 2019 (COVID‐19). The post‐hospitalization needs of COVID‐19 patients were not understood and no outpatient rehabilitation programs had been described. OBJECTIVE: To evaluate whether a virtual rehabilitation program would lead to im... | input | 2 | 81,908 | 91 | 245,316 |
Please summerize the given abstract to a title | instruction | 0 | 82,018 | 91 | 245,644 |
Recommendations for the recognition, diagnosis, and management of long COVID: a Delphi study | output | 1 | 82,018 | 91 | 245,645 |
BACKGROUND: In the absence of research into therapies and care pathways for long COVID, guidance based on ‘emerging experience’ is needed. AIM: To provide a rapid expert guide for GPs and long COVID clinical services. DESIGN AND SETTING: A Delphi study was conducted with a panel of primary and secondary care doctors. M... | input | 2 | 82,018 | 91 | 245,646 |
Please summerize the given abstract to a title | instruction | 0 | 82,170 | 91 | 246,100 |
Implications of interleukin-6 (IL-6)-blockade for severe COVID-19 infection in patients with multiple myeloma | output | 1 | 82,170 | 91 | 246,101 |
Cancer patients are at a higher risk of “Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)” infection than patients without cancer In particular, Multiple Myeloma (MM) patients are at serious risk of contracting this severe infection because of many factors, such as immunosuppression, comorbidities, immune d... | input | 2 | 82,170 | 91 | 246,102 |
Please summerize the given abstract to a title | instruction | 0 | 82,173 | 91 | 246,109 |
Managing comorbidities in Covid-19 patients: A drug utilization study in a COVID-dedicated hospital in Northern India | output | 1 | 82,173 | 91 | 246,110 |
INTRODUCTION: In the prevailing COVID-19 pandemic, the Indian healthcare system has worked hard towards restricting the adverse outcomes to the least possible figures. The present study aims to share the experience of a COVID-dedicated tertiary care government hospital in Northern India of managing COVID-19 patients wi... | input | 2 | 82,173 | 91 | 246,111 |
Please summerize the given abstract to a title | instruction | 0 | 82,175 | 91 | 246,115 |
Renin-angiotensin-system inhibitors and all-cause mortality in patients with coronavirus disease 2019: a systematic review and meta-analysis of observational studies. | output | 1 | 82,175 | 91 | 246,116 |
AIMS We sought to evaluate the association of angiotensin-converting-enzyme inhibitors (ACEI) or AT1 blockers (ARB) therapy with clinical outcomes in patients with coronavirus disease 2019 (COVID-19). METHODS AND RESULTS Electronic databases were searched to identify published studies that reported clinical outcomes in... | input | 2 | 82,175 | 91 | 246,117 |
Please summerize the given abstract to a title | instruction | 0 | 82,313 | 91 | 246,529 |
Tocilizumab for the treatment of COVID-19 among hospitalized patients: A matched retrospective cohort analysis | output | 1 | 82,313 | 91 | 246,530 |
BACKGROUND: There is currently no single treatment that mitigates all harms caused by SARS-CoV-2 infection. Tocilizumab, an interleukin-6 antagonist, may have a role as adjunctive immune-modulating therapy. METHODS: This was an observational, retrospective study of hospitalized adult patients with confirmed COVID-19. T... | input | 2 | 82,313 | 91 | 246,531 |
Please summerize the given abstract to a title | instruction | 0 | 82,336 | 91 | 246,598 |
Another step toward final call on Remdesivir efficacy as a treatment for hospitalized COVID-19 patients: a multicenter open-label trial | output | 1 | 82,336 | 91 | 246,599 |
IntroductionAfter emerging the global pandemic of SARS-CoV2 some preliminary studies demonstrated the efficacy of antiviral treatments. But shortly thereafter, inconsistencies in the results of further clinical trials raised doubts on the efficacy of these agents. In this study, we aimed to evaluate the effect of Remde... | input | 2 | 82,336 | 91 | 246,600 |
Please summerize the given abstract to a title | instruction | 0 | 82,422 | 91 | 246,856 |
POSA21 An In-Hospital Study to Trace the Risk Factors Associated with Adverse Drug Reactions during the Second Wave of COVID-19 in a Secondary Care Hospital in India | output | 1 | 82,422 | 91 | 246,857 |
Objectives: To characterize the adverse drug reactions (ADRs) and the risk factors associated with COVID -19 treatment in a secondary care hospital in South India. Methods: A prospective observational study was carried out on 327 patients admitted between April 1 and May 15, 2021, using an in-person surveillance system... | input | 2 | 82,422 | 91 | 246,858 |
Please summerize the given abstract to a title | instruction | 0 | 82,511 | 91 | 247,123 |
Clinical impact of combination therapy with baricitinib, remdesivir, and dexamethasone in patients with severe COVID-19 | output | 1 | 82,511 | 91 | 247,124 |
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