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Combinatorial Games: Tic-Tac-Toe Theory is a monograph on the mathematics of tic-tac-toe and other positional games, written by József Beck. It was published in 2008 by the Cambridge University Press as volume 114 of their Encyclopedia of Mathematics and its Applications book series (ISBN 978-0-521-46100-9). | https://en.wikipedia.org/wiki/Combinatorial_Games:_Tic-Tac-Toe_Theory |
Toast the bread and soak it in the wine, set it before the fire, cut your cheese in very thin slices, rub butter over the bottom of a plate, lay the cheese on, pour in two or three spoonfuls of white wine, cover it with another plate, set it over a chafing-dish of hot coals for two or three minutes, then stir it till it is done and well mixed. You may stir in a little mustard; when it is enough lay it on the bread, just brown it with a hot shovel. Served with an egg on top, it makes a buck rabbit or a golden buck.Welsh rarebit blended with tomato (or tomato soup) makes a blushing bunny.In France, un Welsh is popular in the Nord-Pas-de-Calais and Côte d'Opale regions. | https://en.wikipedia.org/wiki/Welsh_rarebit |
Midnight parrotfish are cited as 'Least Concern' on the IUCN Red List. This is due to the high concentrations of midnight parrotfish in the Gulf of Mexico and Caribbean. Midnight parrotfish are protected species in United States waters, as well as a number of marine protected areas in the Caribbean. However, Cuban spear-fishers often target the midnight parrotfish along with other parrotfish species, which has led to a slight decline in population. | https://en.wikipedia.org/wiki/Midnight_parrotfish |
An operating system (OS) manages computer resources and provides programmers with an interface used to access those resources. An operating system processes system data and user input, and responds by allocating and managing tasks and internal system resources as a service to users and programs of the system. An operating system performs basic tasks such as controlling and allocating memory, prioritizing system requests, controlling input and output devices, facilitating computer networking, and managing files. Common contemporary desktop operating systems are Microsoft Windows, macOS, Linux, Solaris and FreeBSD. | https://en.wikipedia.org/wiki/Personal_computers |
Copper alloys are metal alloys that have copper as their principal component. They have high resistance against corrosion. The best known traditional types are bronze, where tin is a significant addition, and brass, using zinc instead. Both of these are imprecise terms, having both been commonly referred to as lattens in the past. Today the term copper alloy tends to be substituted, especially by museums. | https://en.wikipedia.org/wiki/List_of_copper_alloys |
The northern two-lined salamander is a small salamander, with adults ranging from 65–120 mm in total length. This salamander is yellow or yellowish-brown, with two black stripes running down the back which tends to break up after the base of the tail. The flanks are mottled grayish or brown. The belly is pale yellowish, nearly transparent. There are four toes on the fore feet and five toes on the hind feet. On the side of the body are 14–16 costal grooves. | https://en.wikipedia.org/wiki/Northern_two-lined_salamander |
This explains why SI to ESU conversions involving factors of c2 lead to significant simplifications of the ESU units, such as 1 statF = 1 cm and 1 statΩ = 1 s/cm: this is the consequence of the fact that in ESU system kC = 1. For example, a centimetre of capacitance is the capacitance of a sphere of radius 1 cm in vacuum. The capacitance C between two concentric spheres of radii R and r in ESU CGS system is: 1 1 r − 1 R {\displaystyle {\frac {1}{{\frac {1}{r}}-{\frac {1}{R}}}}} .By taking the limit as R goes to infinity we see C equals r. | https://en.wikipedia.org/wiki/Centimetre–gram–second_system_of_units |
Then, each subsequent items of the collection may replace the largest or smallest element in the heap (respectively for heapq.nsmallest and heapq.nlargest) if it is smaller or larger than this element. The worst-case time for this implementation is O ( n log k ) {\displaystyle O(n\log k)} , worse than the O ( n + k log n ) {\displaystyle O(n+k\log n)} that would be achieved by heapselect. However, for random input sequences, there are likely to be few heap updates and most input elements are processed with only a single comparison.Since 2017, Matlab has included maxk() and mink() functions, which return the maximal (minimal) k {\displaystyle k} values in a vector as well as their indices. The Matlab documentation does not specify which algorithm these functions use or what their running time is. | https://en.wikipedia.org/wiki/Selection_algorithm |
Lenses are labelled Rokkor (pre-set) or Auto Rokkor (automatic diaphragm) MC - 1966-1977: Meter coupling added (often called MC mount) allowing full-aperture TTL measurement. Lenses are labelled MC Rokkor. MD - 1977-2001: MD lever added, which allows the reading of the smallest available aperture, often referred to as MD mount. | https://en.wikipedia.org/wiki/Minolta_SR_mount |
Whitley interpreted the final stage, in which hero-cult was co-opted by the city-state as a political gesture, in the archaic aristocratic tumulus surrounded by stelae, erected by Athens to the cremated citizen-heroes of Marathon (490 BC), to whom chthonic cult was dedicated, as the offering trenches indicate. On the other hand, Greek heroes were distinct from the Roman cult of dead emperors, because the hero was not thought of as having ascended to Olympus or become a god: he was beneath the earth, and his power purely local. For this reason hero cults were chthonic in nature, and their rituals more closely resembled those for Hecate and Persephone than those for Zeus and Apollo: libations in the dark hours, sacrifices that were not shared by the living. | https://en.wikipedia.org/wiki/Greek_hero_cult |
On clocks that display local time tied to UTC, the leap second may be inserted at the end of some other hour (or half-hour or quarter-hour), depending on the local time zone. A negative leap second would suppress second 23:59:59 of the last day of a chosen month so that second 23:59:58 of that date would be followed immediately by second 00:00:00 of the following date. Since the introduction of leap seconds, the mean solar day has outpaced atomic time only for very brief periods and has not triggered a negative leap second. | https://en.wikipedia.org/wiki/Leap_second |
The French search for Venetian artworks was led by Monge, Berthollet, the artist Berthélemy, and Tinet, who had previously been in Modena. After the defeat of the Venetian Republic, there were several revolts against the occupying French armies. : 78 The resulting reprisals and confiscations were particularly harsh. Gold and silver works from the Zecca of Venice and the Basilica di San Marco were melted down and sent to France or used to pay soldiers' salaries. | https://en.wikipedia.org/wiki/Napoleonic_looting_of_art |
In particular, mechanisms for the microwave-driven DNP processes are categorized into the Overhauser effect (OE), the solid-effect (SE), the cross-effect (CE) and thermal-mixing (TM). The first DNP experiments were performed in the early 1950s at low magnetic fields but until recently the technique was of limited applicability for high-frequency, high-field NMR spectroscopy, because of the lack of microwave (or terahertz) sources operating at the appropriate frequency. Today such sources are available as turn-key instruments, making DNP a valuable and indispensable method especially in the field of structure determination by high-resolution solid-state NMR spectroscopy. | https://en.wikipedia.org/wiki/Overhauser_Effect |
A somewhat uncommon variant is YGHJ which while requiring the keyboard to be turned slightly clockwise, can result in the thumb resting comfortably upon the right Alt key and the little finger resting on C. This can be useful in games that utilize both jump and sprint functions as it allows the fingers to rest on smaller keys than ⇧ Shift and Space. The YGHJ configuration also places the hand closer to the center of the QWERTY section of the keyboard, potentially opening up the entire board to custom keybindings. The game QWOP uses the control scheme "QWOP" to control Qwop's arms and legs. | https://en.wikipedia.org/wiki/Arrow_key |
A delta formed where the valley entered the crater.This type of event involving volcanic heat melting glaciers is common in Iceland. Eruptions under glaciers are called jökulhlaups and average two each century. Studies of climate change show that many low-latitude regions accumulated large amounts of snow when the climate was different. | https://en.wikipedia.org/wiki/Rahe_(crater) |
This also means that muscle cells are able to take in more glucose as its intracellular concentrations decrease. In order to increase glucose levels in the cell, GLUT4 is the primary transporter used in this facilitated diffusion.Although muscle contractions function in a similar way and also induce the translocation of GLUT4 into the plasma membrane, the two skeletal muscle processes obtain different forms of intracellular GLUT4. The GLUT4 carrier vesicles are either transferrin positive or negative, and are recruited by different stimuli. Transferrin-positive GLUT4 vesicles are utilized during muscle contraction while the transferrin-negative vesicles are activated by insulin stimulation as well as by exercise. | https://en.wikipedia.org/wiki/GLUT_4 |
If there is excessive menstrual and uterine bleeding other than that caused by menstruation, menometrorrhagia (meno = prolonged, metro = time, rrhagia = excessive flow/discharge) may be diagnosed. Causes may be due to abnormal blood clotting, disruption of normal hormonal regulation of periods or disorders of the endometrial lining of the uterus. Depending upon the cause, it may be associated with abnormally painful periods. | https://en.wikipedia.org/wiki/Menstrual_disorder |
Kalahandia Odia: Variant of Odia spoken in Kalahandi and Nuapada districts and neighbouring districts of Chhattisgarh. Debagadia Odia: Variant of Odia spoken in Debagarh district and the adjoining Rairakhol, Athmallik area. It is known as Debgadia or Deogarhia. | https://en.wikipedia.org/wiki/Oriya_language |
Tom's Hardware tested 14 different cables and found that 11 of them turned on and powered the Pi without issue. The design flaw was fixed in revision 1.2 of the board, released in late 2019. In mid-2021, Pi 4 B models appeared with the improved Broadcom BCM2711C0. | https://en.wikipedia.org/wiki/Raspberry_Pi |
In chemistry, a phosphide is a compound containing the P3− ion or its equivalent. Many different phosphides are known, with widely differing structures. Most commonly encountered on the binary phosphides, i.e. those materials consisting only of phosphorus and a less electronegative element. Numerous are polyphosphides, which are solids consisting of anionic chains or clusters of phosphorus. Phosphides are known with the majority of less electronegative elements with the exception of Hg, Pb, Sb, Bi, Te, and Po. Finally, some phosphides are molecular. | https://en.wikipedia.org/wiki/Phosphide |
Advantages of indium cryogenic seals: Established/proven design techniques for indium seal assembly Option for disassembly and re-assembly Indium can be reformed into useful seals after use Soft and pliable at room temperature, due to the low melting temperature of indium, so it fills imperfections. This creates an impervious bond between the mating surfaces, crafting a hermetic seal which remains malleable at cryogenic temperatures Seal integrity remains following thermal shock from room temperature to immersion in cryogenic bath Seal quality is independent of the mating surface composition, for instance ceramic, germanium, metal, or glass. Indium forms a self-passivating oxide layer, 80-100Ǻ thick. This layer is easy to remove with an acid etch, and the underlying, exposed indium metal can be compressed to form a tight, hermetic bond. | https://en.wikipedia.org/wiki/Cryogenic_seal |
Black Brant I Payload: 68 kg (150 lb) Maximum flight height: 225 km (140 mi) Launch thrust: 111 kN (25,000 lbf) Launch mass: 730 kg (1,610 lb) Diameter: 0.26 m (10 in) Length: 7.41 m (24.3 ft) | https://en.wikipedia.org/wiki/Black_Brant_(rocket) |
The HP Integral PC (or HP 9807A) is a portable UNIX workstation computer system produced by Hewlett-Packard, launched in 1985 at a price of £5450. It utilizes the Motorola 68000 microprocessor (running at 8 MHz) and ran the HP-UX 1.0 operating system. | https://en.wikipedia.org/wiki/HP_Integral_PC |
The letter eta (Η, , originally called hēta) had two different functions, both derived from the name of its Phoenician model, hēth: the majority of Greek dialects continued to use it for the consonant /h/, similar to its Phoenician value (). However, the consonant /h/ was progressively lost from the spoken language (a process known as psilosis), and in those dialects where this had already happened early on in the archaic period, Η was instead used to denote the long vowel /ɛː/, which occurred next in its name and was thus, in the /h/-less dialects, its natural acrophonic value. Early psilotic dialects include eastern Ionic Greek, the Aeolic Greek of Lesbos, as well as the Doric Greek of Crete and Elis.The distribution of vocalic Η and Ε differs further between dialects, because the Greek language had a system of three distinct e-like phonemes: the long open-mid /ɛː/ (classical spelling η), the long close-mid /eː/ (later merged with the diphthong /ei/, classical spelling ει), and the short vowel /e/ (classical spelling ε). In the psilotic dialects of Anatolia and adjacent eastern Aegean islands, as well as Crete, vocalic Η was used only for /ɛː/. | https://en.wikipedia.org/wiki/Archaic_Greek_alphabets |
Others focused only on the US and on outside the US by studying the performance of 29 SRI indices globally. Using the capital asset pricing model to estimate Jensen's alpha as the performance indicator, no significant evidence of under/over performance was found. A comparison of the performance of SR indices with conventional indices on a global scale using marginal conditional stochastic dominance found there is "strong evidence that there is a financial price to be paid for socially responsible investing. "A more recent study showed that "improvements in CSR reputation enhance profits". | https://en.wikipedia.org/wiki/Social_investment_websites |
Chatham Square was laid out in 1847 and named in 1851 for William Pitt, 1st Earl of Chatham. Although Pitt never visited Savannah he was an early supporter of the Georgia colony and both Chatham Square and Chatham County are named in his honor. The square is sometimes known locally as Barnard Square, in reference to the 1901-built Barnard Street School (which actually stands at 212 West Taylor Street) and has served as a building for the Savannah College of Art and Design since 1988. The college renamed it Pepe Hall. | https://en.wikipedia.org/wiki/Squares_of_Savannah,_Georgia |
The hybrid prototype held its first public test flight on June 6, 2019, before scheduled service planned for 2021. Personal Airline Exchange (PAX) became the launch customer for the Ampaire Electric EEL modified six-seat Skymaster, to be certified in 2021, with an order for 50 plus 50 options.By March 2019, UTC was converting a 39-seat Bombardier Dash 8 Q100 into a hybrid-electric for demonstration flights from 2022 within its Project 804. The 2 MW (2,700 hp) design is similar to the Airbus E-Fan X program, but aims for certification and production for a subsequent commercial offer. | https://en.wikipedia.org/wiki/Hybrid_electric_aircraft |
But before their wedding, he receives a note from Kitty breaking off the engagement, and telling him she is going abroad. Rainier goes on to disclose to Harrison that Kitty was to die soon after. Meantime, war is on the horizon, and Harrison and Rainier spend time together going to music halls and working. | https://en.wikipedia.org/wiki/Random_Harvest |
In practice however, most provincial departments do not have the administrative capability to register children for home education. Some of the larger provincial departments have limited administrative capabilities to register children for home education as well as a lack of follow up capacity, resulting in a serious miscommunication between government and citizens. As a result of this situation, more than 90% of homeschooling parents do not register with the department. Since home education was legalised, it has grown exponentially. According to the census count of 2011, there were about 57,000 home learners in the country, putting South Africa in the top five countries in terms of number of home learners. | https://en.wikipedia.org/wiki/Homeschooling_international_status_and_statistics |
In the Critique of Pure Reason, Immanuel Kant argued against materialism in defending his transcendental idealism (as well as offering arguments against subjective idealism and mind–body dualism). But Kant argues that change and time require an enduring substrate.Postmodern/poststructuralist thinkers also express skepticism about any all-encompassing metaphysical scheme. Philosopher Mary Midgley argues that materialism is a self-refuting idea, at least in its eliminative materialist form. | https://en.wikipedia.org/wiki/Philosophical_materialism |
Bioseparations on a production scale are enhanced by monolith column technologies as well. The fast separations and high resolving power of monoliths for large molecules means that real-time analysis on production fermentors is possible. Fermentation is well known for its use in making alcoholic beverages, but is also an essential step in the production of vaccines for rabies and other viruses. | https://en.wikipedia.org/wiki/Monolithic_HPLC_column |
Fewer students enrolled from areas with more limited access to the internet, and students from the People's Republic of China may have been discouraged by Chinese government policies.Koller stated in May 2013 that a majority of the people taking Coursera courses had already earned college degrees.According to a Stanford University study of a more general group of students "active learners" – anybody who participated beyond just registering – found that 64% of high school active learners were male and 88% were male for undergraduate- and graduate-level courses.A study from Stanford University's Learning Analytics group identified four types of students: auditors, who watched video throughout the course, but took few quizzes or exams; completers, who viewed most lectures and took part in most assessments; disengaged learners, who quickly dropped the course; and sampling learners, who might only occasionally watch lectures. They identified the following percentages in each group: Jonathan Haber focused on questions of what students are learning and student demographics. About half the students taking US courses are from other countries and do not speak English as their first language. | https://en.wikipedia.org/wiki/Massive_Open_Online_Course |
The Japanese made a number of minor changes to the original Hotchkiss design and production process, changing some components from forgings to castings to simplify production, and replacing the simple conical flash suppressor with a Rheinmetall-type design. A submarine-mountable version of the gun which made extensive use of stainless steel was also produced. The double-mount type was the first to enter service, with triple mounts following in 1941 and finally single mounts later in 1943. | https://en.wikipedia.org/wiki/Type_96_25_mm_AT/AA_Gun |
A sequence of continuous functions on metric spaces, with the image metric space being complete, is uniformly convergent if and only if it is uniformly Cauchy. If S {\displaystyle S} is a compact interval (or in general a compact topological space), and ( f n ) {\displaystyle (f_{n})} is a monotone increasing sequence (meaning f n ( x ) ≤ f n + 1 ( x ) {\displaystyle f_{n}(x)\leq f_{n+1}(x)} for all n and x) of continuous functions with a pointwise limit f {\displaystyle f} which is also continuous, then the convergence is necessarily uniform (Dini's theorem). Uniform convergence is also guaranteed if S {\displaystyle S} is a compact interval and ( f n ) {\displaystyle (f_{n})} is an equicontinuous sequence that converges pointwise. | https://en.wikipedia.org/wiki/Local_uniform_convergence |
In other words, media naturalness theory places the face-to-face medium at the center of a one-dimensional scale of naturalness, where deviations to the left or right are associated with decreases in naturalness (see Figure 1). Electronic media that enable the exchange of significantly more communicative stimuli per unit of time than the face-to-face medium are classified by media naturalness theory as having a lower degree of naturalness than the face-to-face medium. As such, those media are predicted to be associated with higher cognitive effort; in this case due primarily to a phenomenon known as information overload, which is characterized by individuals having more communicative stimuli to process than they are able to. | https://en.wikipedia.org/wiki/Media_naturalness_theory |
Modern scholars have identified the source of the second version in a lost work written by the Agiad king Pausanias after he had been forced to abdicate and go into exile in 394 BCE. In this logos, Pausanias likely published Lycurgus' laws, including the Rhetra, which details the different element of the Spartan constitution (kings, gerousia, ekklesia), but does not mention the ephors. It has therefore been suggested that Pausanias was hostile to the ephors, to whom he possibly attributed his banishment, and published the Rhetra to discredit their office. | https://en.wikipedia.org/wiki/Ephor |
For example, a research paper published in 1999, by scientists from Finland's National Public Health Institute, reports the effect of environmental chemicals and changes in sex ratio over 250 years in Finland. This scientific team evaluated whether Finnish long-term data are compatible with the hypothesis that the decrease in the ratio of male to female births in industrial countries is caused by environmental factors. They analyzed the sex ratio of births from the files of Statistics Finland and all live births in Finland from 1751 to 1997. | https://en.wikipedia.org/wiki/Human_sex_ratio |
Craven and Lee rebutted this paper in a reply that concentrated on holding therapy rather than dyadic developmental psychotherapy.It appears from the reports that attachment therapy techniques may have been used in addition to standard DDP. The therapist in Becker-Weidman's study instructed parents to use the "attachment parenting methods" of two authors who are described by Jean Mercer as advocating "coercive and intimidating approaches to children in treatment", specifically physical restraint and withholding of food and drink. Because of this deviation from the modern presentation of DDP, Mercer argues that the study cannot be considered a test of DDP in its current form. Mercer cites Becker-Weidman's research as an example of the Woozle effect, in which "flawed, limited, or exaggerated data" is uncritically repeated and republished until it achieves popular acceptance. | https://en.wikipedia.org/wiki/Dyadic_developmental_psychotherapy |
Originally, all signaling was done by mechanical means. Points and signals were operated locally from individual levers or handles, requiring the signalman to walk between the various pieces of equipment to set them in the required position for each train that passed. Before long, it was realized that control should be concentrated into one building, which came to be known as a signal box. The signal box provided a dry, climate-controlled space for the complex interlocking mechanics and also the signalman. | https://en.wikipedia.org/wiki/Interlocking_tower |
Pareto stated the first fundamental theorem in his Manuale (1906) and with more rigour in its French revision (Manuel, 1909). He was the first to claim optimality under his own criterion or to support the claim by convincing arguments.He defines equilibrium more abstractly than Edgeworth as a state which would maintain itself indefinitely in the absence of external pressures and shows that in an exchange economy it is the point at which a common tangent to the parties' indifference curves passes through the endowment.His definition of optimality is given in Chap. VI: We will say that the members of a collectivity enjoy a maximum of ophelimity at a certain position when it is impossible to move a small step away such that the ophelimity enjoyed by each individual in the collectivity increases, or such that it diminishes. That is to say that any small step is bound to increase the ophelimity of some individuals while diminishing that of others. | https://en.wikipedia.org/wiki/Second_welfare_theorem |
Meanwhile, in description of the economic approach, the anti-competitive practices is also a useful approach to sustain a stabilized economic development and national welfare. With the implementation of anti-competitive practices, it will effectively remove the market inefficiencies and eliminate the dead weight loss from the economic viewpoint. As firms engage in the fair competition act with the government regulations and laws. There is sufficient evidence to conclude that, the utilization of anti-competitive practices can dramatically reduce the phenomenon of black market, hence improves the investment incentives on aggregate demands. In general, with the effective implementation of anti-competitive practices, the whole economy will expand into a further prosperity with less crowing out effects. | https://en.wikipedia.org/wiki/Anticompetitive_practice |
Variations in the frequency. Nonzero low-frequency impedance (when a load draws more power, the voltage drops). Nonzero high-frequency impedance (when a load demands a large amount of current, then suddenly stops demanding it, there will be a dip or spike in the voltage due to the inductances in the power supply line). Variations in the wave shape – usually described as harmonics at lower frequencies (usually less than 3 kHz) and described as Common Mode Distortion or Interharmonics at higher frequencies. | https://en.wikipedia.org/wiki/Electric_power_quality |
Conversely, active concealment of pornography use habits can lead to less openness in communication and trust.Another important aspect is the communication of affection within relationships. Affection Exchange Theory establishes the inherent role of affection within romantic relationships, and even in the role of survival, reproduction, and sexual selection. Trait attachment is positively associated with relationship satisfaction. | https://en.wikipedia.org/wiki/Effects_of_pornography |
Later, mutations in complement factor H, complement factor I, membrane cofactor protein, factor B, C3, and thrombomodulin have now been found to cause many of the familial cases of aHUS. These discoveries have allowed a more comprehensive understanding of the pathogenesis, evaluation, and treatment of the entire spectrum of TMA disorders and provide a more rational and effective approach to the care of these children with complicated disease. Prior to the use of monoclonal antibodies patients with aHUS had an extremely poor prognosis. | https://en.wikipedia.org/wiki/Hemolytic-uremic_syndrome |
The apparent absence of this layer on Venus suggests that the deformation of the Venusian surface must be explained by convective movements within the planet's mantle. The tectonic deformations on Venus occur on a variety of scales, the smallest of which are related to linear fractures or faults. In many areas these faults appear as networks of parallel lines. | https://en.wikipedia.org/wiki/Geology_of_Venus |
The Sand and Gravel Aquifer stretches 2,400 square miles (6,200 km2) across the panhandle of Florida and is replenished with rainfall. Over the years water levels have dropped due to water-well use by pumping, and it has been contaminated by industrial waste and saltwater intrusion. The Chokoloskee Aquifer is surficial aquifer that covers 3,000 square miles (7,800 km2) in southwest Florida. It is recharged by rainfall. It is believed that artificial drainage canals have lowered water levels and increased saltwater intrusion. | https://en.wikipedia.org/wiki/Surficial_aquifer |
Doctor Who: The Monthly Adventures Doctor Who: The Fourth Doctor Adventures Doctor Who: The Fifth Doctor Adventures Doctor Who: Novel Adaptations Doctor Who: Special Releases Doctor Who: The Companion ChroniclesThe Darkening Eye (narrated by Nyssa) The Invasion of E-Space (narrated by Romana II)Doctor Who: Short Trips Doctor Who: The Audio Novels | https://en.wikipedia.org/wiki/Adric |
Due to a tighter optical focus, OR-PAM is more useful for imaging in the quasi-ballistic range of depths up to 1 mm. The lateral resolution of OR-PAM is determined by the formula: R l a t e r a l , O = 0.51 λ O N A O , {\displaystyle R_{lateral,O}=0.51{\frac {\lambda _{O}}{NA_{O}}},} where λ O {\displaystyle \lambda _{O}} is the optical wavelength and N A O {\displaystyle NA_{O}} is the numerical aperture of the optical objective lens. The lateral resolution of OR-PAM can be improved by using a shorter laser pulse and tighter focusing of the laser spot. OR-PAM systems can typically achieve a lateral resolution of 0.2 to 10 μm, allowing OR-PAM to be classified as a super-resolution imaging method. | https://en.wikipedia.org/wiki/Photoacoustic_microscopy |
A bill of exchange or "draft" is a written order by the drawer to the drawee to pay money to the payee. A common type of bill of exchange is the cheque (check in American English), defined as a bill of exchange drawn on a banker and payable on demand. Bills of exchange are used primarily in international trade, and are written orders by one person to his bank to pay the bearer a specific sum on a specific date. Prior to the advent of paper currency, bills of exchange were a common means of exchange. | https://en.wikipedia.org/wiki/Negotiable_instrument |
: 382 Recipients of these personality assessments consistently fail to distinguish between common and uncommon personality descriptors. : 383 In a study by Paul Rogers and Janice Soule (2009), which was consistent with previous research on the issue, it was found that those who believed in astrology are generally more susceptible to giving more credence to the Barnum profile than sceptics. : 393 By a process known as self-attribution, it has been shown in numerous studies that individuals with knowledge of astrology tend to describe their personalities in terms of traits compatible with their sun signs. The effect is heightened when the individuals were aware that the personality description was being used to discuss astrology. Individuals who were not familiar with astrology had no such tendency. | https://en.wikipedia.org/wiki/Astrology_and_science |
In 1962, SK, along with manufacturing partner Lectrolite Corp., of Defiance, Ohio, was bought out by Symington-Wayne and became S-K Wayne.In 1968 S-K Wayne was purchased by Dresser Industries as part of the merger between Wayne Oil and Tank Company and Dresser Industries. Dresser Industries made many changes to S-K's tools including dropping the cross-hatch pattern from their sockets in order to "modernize" them. In 1985, SK became part of the French company Facom Tools. | https://en.wikipedia.org/wiki/SK_Hand_Tools |
Before the mechanical lawn mower, the upkeep of lawns was possible only for the extremely wealthy estates and manor houses of the aristocracy. Labor-intensive methods of scything and shearing the grass were required to maintain the lawn in its correct state, and most of the land in England was required for more functional, agricultural purposes. This all changed with the invention of the lawn mower by Edwin Beard Budding in 1830. Budding had the idea for a lawn mower after seeing a machine in a local cloth mill which used a cutting cylinder (or bladed reel) mounted on a bench to trim the irregular nap from the surface of woolen cloth and give a smooth finish. | https://en.wikipedia.org/wiki/Lawn |
Generally, according to the law of probability, the shorter the work, the longer the minimal pangrammatic window (if any) will be. Some estimates can be made using the frequencies of the letters. Assuming that the incidence of each letter in a passage is independent of the incidence of the other letters, and provided m is much larger than 26, the probability that a sequence of length m will contain all 26 letters is approximately P(a)P(b)...P(y)P(z), where P(letter) = 1 − (1 − p(letter))m and p(letter) is the frequency of the letter as a fraction (e.g. 5% is 0.05). Inputting the letter frequencies for the English language, the probability that a 1,700-letter sequence will contain all 26 letters is about 50%. | https://en.wikipedia.org/wiki/Pangrammatic_window |
Three species of filarial roundworms, all from the Onchocercidae family, cause human lymphatic filariasis: Wuchereria bancrofti (the most common causative species), Brugia malayi, and Brugia timori. The filarial roundworms are transmitted by the bite of an infected mosquito of genera Aedes, Anopheles, Culex, or Mansonia. The mosquito deposits the L3 (infective stage) larvae onto the skin of the human host, where they penetrate into the bite wound. From there, the larvae enter the lymphatic vessels and develop into adults. | https://en.wikipedia.org/wiki/Elephantiasis_tropica |
Recommendations on nomenclatures still differ widely across different regulatory bodies (IUPAC, CAS, MDL). According to IUPAC star-shaped polymers are designated by a star prefix which can be further specified as f-star when the number of arms f is known. An example would be star-(polyA; polyB; polyC) for a variegated (heteroarm) star polymer with three arm species, but an undefined number of arms and distribution of arms. When the number of arms and its distribution is known this can be designated as for example 6-star-(polyA(f3); polyB(f3)) where 6 arms exist in total whereof 3 consist of polyA polymer. Stars containing only one species (same chemistry and molar mass) of arms are called regular stars (also called homo-arm). Stars with more than one arm species are designated as variegated stars (hetero-arm). | https://en.wikipedia.org/wiki/Star_polymers |
If sexual abuse is suspected, questions regarding this are discussed after the examination and not during it. When the patient is requested to 'bear down', the presence of prolapsed structures such as the bladder (cystocele), rectum (rectocele) or uterus are documented. Prolapsed structures can appear when abdominal pressure increases or they can protrude without bearing down. | https://en.wikipedia.org/wiki/Pelvic_examination |
Writer Yangsze Choo's 2013 novel The Ghost Bride used the principles of ghost marriage as its central premise. It became a New York Times best-seller, and was selected as a Best Book by Oprah.com. It later formed the basis of the Netflix-original series The Ghost Bride, which was co-directed by Malaysian directors Quek Shio-chuan and Ho Yu-hang. It starred Huang Pei-jia, Wu Kang-jen, Ludi Lin, and Kuang Tian.Marry My Dead Body featured a ghost marriage as its main plot point. It was selected as the closing film for the 2022 Golden Horse International Film Festival. | https://en.wikipedia.org/wiki/Chinese_ghost_marriage |
1968 In addition to testing in Japan, prototype testing under the code name 'N100' included high-speed runs in the desert of the US southwest where many paved highways did not yet have speed limits. H1 500 cc (31 cu in) Mach III (September) White w/blue stripes, distributor CDI ignition, drum front brake, "Mach III 500" badge on side cover and "electronic ignition" decal on oil tank. Early 69 models had bridged port intake design, with "windowed" carbs. | https://en.wikipedia.org/wiki/Kawasaki_triple |
The UnionPay app was launched on 11 December 2017, which was merged from the old UnionPay app and UnionPay Wallet (Chinese: 银联钱包). Following that, the app has trailed in popularity behind its two major competitors, however, in 2021, the mandate by the Ministry of Industry and Information Technology (MIIT) to open up the "walled garden" ecosystems of the major tech companies, has allowed for increasing interoperability of payment QR codes of Alipay and WeChat Pay in the process ongoing throughout 2021 and 2022. | https://en.wikipedia.org/wiki/Cloud_QuickPass |
For example, suppose we take an estimator Tn that is both Fisher consistent and asymptotically consistent, and then form Tn + En, where En is a deterministic sequence of nonzero numbers converging to zero. This estimator is asymptotically consistent, but not Fisher consistent for any n. The sample mean is a Fisher consistent and unbiased estimate of the population mean, but not all Fisher consistent estimates are unbiased. Suppose we observe a sample from a uniform distribution on (0,θ) and we wish to estimate θ. The sample maximum is Fisher consistent, but downwardly biased. Conversely, the sample variance is an unbiased estimate of the population variance, but is not Fisher consistent. | https://en.wikipedia.org/wiki/Fisher_consistency |
It was expected to become operational by the end of 2002. Its introduction was delayed and a new implementation date, the end of 2006, was announced. The univisa was originally intended to only be available, initially, to visitors from selected "source markets" including Australia, the Benelux countries, France, Germany, Italy, Japan, Portugal, Spain, the United Kingdom, and the United States. | https://en.wikipedia.org/wiki/Visa-free_travel |
Albéniz and Granados contributed to this movement as they wrote within the same time period.Some classical guitarists play concertos, which are solos written for performance with the accompaniment of an orchestra. Fewer classical guitar concertos have been written compared to concertos for multi-instrumental orchestras. Some potentially notable ones could include Joaquín Rodrigo's Concierto de Aranjuez and Fantasía para un gentilhombre. In the 2000s, it has been noted that classical guitar is appearing more in classical music, as contemporary composers are increasingly writing guitar concertos. | https://en.wikipedia.org/wiki/Guitar_solo |
The effectiveness of anger management has been studied in children and adolescents for the purpose of evaluating existing programs and designing more effective programs. In a meta-analyses of 40 studies, an overall effect size of 0.67 was found for CBT anger management treatment, suggesting anger management as a legitimate approach to problematic levels of anger. Skills development (0.79) and problem solving (0.67) both had a higher impact than affective education (0.36). | https://en.wikipedia.org/wiki/Anger_management |
The difficulty with this approach is that the data is fragile, the format may be archaic, and the data may be easy to falsify. One of the best systems for archiving data series is as computer-generated machine-readable ultrafiche, usually in typefonts such as OCR-B, or as digitized half-tone images. Ultrafiches survive well in standard libraries, with lifetimes of several centuries. | https://en.wikipedia.org/wiki/Remote_sensing_satellites |
A heat engine is a system that performs the conversion of a flow of thermal energy (heat) to mechanical energy to perform mechanical work.A thermocouple is a temperature-measuring device and widely used type of temperature sensor for measurement and control, and can also be used to convert heat into electric power. A thermoelectric cooler is a solid state electronic device that pumps (transfers) heat from one side of the device to the other when electric current is passed through it. It is based on the Peltier effect. A thermal diode or thermal rectifier is a device that causes heat to flow preferentially in one direction. | https://en.wikipedia.org/wiki/Heat_loss |
The ability to generate conversation that cannot be distinguished from a human participant has been one test of a successful artificial intelligence (the Turing test). A human judge engages in a natural-language conversation with one human and one machine, during which the machine tries to appear human (and the human does not try to appear other than human). If the judge cannot tell the machine from the human, the machine is said to have passed the test. One limitation of this test is that the conversation is by text as opposed to speech, not allowing tone to be shown. | https://en.wikipedia.org/wiki/Oral_Communication |
Denver, Colorado In February 2016, the city and county of Denver announced its commitment to Vision Zero. As one of 20 Vision Zero cities at the time, Denver set a goal of zero deaths by 2030. The Denver Streets Partnership coalition organizes periodic Denver Streets Congress meetings to present, discuss and plan Vision Zero policy, funding and implementation of people-friendly street programs. | https://en.wikipedia.org/wiki/Vision_Zero |
The Lavin-Bernick Center for University Life (LBC) was renovated to be a green, environmentally friendly building and opened for student use in January 2007. In 2009, the university altered McAlister Drive, a street that ran through the middle of the uptown campus into a pedestrian walkway renamed McAlister Place. The area was resurfaced, and the newly added green spaces were adorned with Japanese magnolias, irises and new lighting. | https://en.wikipedia.org/wiki/Tulane_University |
A properly designed NFT system is based on using the right channel slope, the right flow rate, and the right channel length. The main advantage of the NFT system over other forms of hydroponics is that the plant roots are exposed to adequate supplies of water, oxygen, and nutrients. In all other forms of production, there is a conflict between the supply of these requirements, since excessive or deficient amounts of one results in an imbalance of one or both of the others. | https://en.wikipedia.org/wiki/Soilless_gardening |
Boleslav Vladimirovich Likhterman (Russian: Болеслав Владимирович Лихтерман; October 14, 1902 – January 20, 1967) was a Soviet medical researcher. He is best remembered as a pioneer in the use of high frequency electrical currents in the treatment of physical ailments and as an editor of the academic journal Voprosi Kurortologii, Physiotherapii i Lechebnoi Physicheskoi Kultury (Problems of Balneology, Physiotherapy, and Therapeutic Physical Exercises). | https://en.wikipedia.org/wiki/Boleslav_Likhterman |
The Adventures of Jimmy Neutron, Boy Genius "Brobot" "The Big Pinch" "Granny Baby" "Time is Money"All Grown Up! "Susie Sings the Blues" "Coup de Ville"Dora the Explorer "3 Little Piggies" "The Big River"The Fairly OddParents Volume 1 "Foul Balled" "The Boy Who Would Be Queen" "The Information Stupor Highway"The Fairly OddParents Volume 2 "Father Time" "Apartnership" "Ruled Out" "That's Life" | https://en.wikipedia.org/wiki/Game_Boy_Advance_Video |
A small spark, such as that produced with static electricity, can easily initiate combustion. The resulting fire produced can be extremely hot and difficult to control.The reduction/melt method and reduction/diffusion method are used to manufacture samarium–cobalt magnets. The reduction/melt method will be described since it is used for both SmCo5 and Sm2Co17 production. | https://en.wikipedia.org/wiki/Samarium-cobalt_magnet |
In real life, though, there is often a situation where the surfaces are not completely dry, but also not so lubricated that they do not touch. This "boundary friction" produces various effects, like an increase in lubrication through the generation of shearing forces, or an oscillation effect during motion, as the friction increases and decreases.For example, one can experience vibration when trying to brake on a partially damp road, or a cold glass that is slowly condensing moisture can be lifted until it spontaneously slides across the surface it is resting on. == References == | https://en.wikipedia.org/wiki/Boundary_friction |
In convex analysis and the calculus of variations, both branches of mathematics, a pseudoconvex function is a function that behaves like a convex function with respect to finding its local minima, but need not actually be convex. Informally, a differentiable function is pseudoconvex if it is increasing in any direction where it has a positive directional derivative. The property must hold in all of the function domain, and not only for nearby points. | https://en.wikipedia.org/wiki/Pseudoconvex_function |
BVD virus can be maintained as a chronic infection within some immunoprivileged sites following transient infection. These sites include ovarian follicles, testicular tissues, central nervous system and white blood cells. Cattle with chronic infections elicit a significant immune response, exhibited by extremely high antibody titres. | https://en.wikipedia.org/wiki/Bovine_virus_diarrhea |
While the Iowa gambling task has proven to be an ecologically valid measure of decision-making impairment, there exist three assumptions that need to hold true. First, the claim that it assesses implicit learning as the reward/punishment design is inconsistent with data showing accurate knowledge of the task possibilities and that mechanisms such as working-memory appear to have a strong influence. Second, the claim that this knowledge occurs through preventive marker signals is not supported by competing explanations of the psychophysiology generated profile. | https://en.wikipedia.org/wiki/Somatic_marker_hypothesis |
Examples include a smiley face and a coarse map of China and the Americas, along with many three-dimensional structures such as cubes. To produce a desired shape, images are drawn with a raster fill of a single long DNA molecule. This design is then fed into a computer program that calculates the placement of individual staple strands. | https://en.wikipedia.org/wiki/DNA_Origami |
Nuclear power plants are typically designed for average life-times between 30 and 40 years. Some believe, nuclear power plants can operate for as long as 80 years or longer with proper maintenance and management. However, some vital parts, notably the reactor vessel and the concrete structures, cannot be replaced when getting cracks and fissures due to neutron embrittlement and wear, thus limiting the life of the plant. At the end of their planned life span, plants may get an extension of the operating license for some 20 years and in the US even a "subsequent license renewal" (SLR) for an additional 20 years.Even when a license is extended, it does not guarantee the reactor will continue to operate, particularly in the face of safety concerns or incident. | https://en.wikipedia.org/wiki/Nuclear_reactors |
Björn Kraus deals with the epistemological perspective upon power regarding the question about possibilities of interpersonal influence by developing a special form of constructivism (named relational constructivism). Instead of focussing on the valuation and distribution of power, he asks first and foremost what the term can describe at all. Coming from Max Weber's definition of power, he realizes that the term of power has to be split into "instructive power" and "destructive power". : 105: 126 More precisely, instructive power means the chance to determine the actions and thoughts of another person, whereas destructive power means the chance to diminish the opportunities of another person. | https://en.wikipedia.org/wiki/Social_power |
In the 1800s in the US, women's and church groups began to establish special homes for elderly people. Often concerned that individuals of their own ethnic or religious communities might die alongside the most despised society, this led to the creation of private care facilities for the elderly in these communities. Poorhouses continued to exist into the early 20th century, despite the criticism of the poor conditions of the poorhouses. | https://en.wikipedia.org/wiki/Nursing_home_care |
Deflector Rotary Saws Homing RobotThe functions abandoned in this version of the Mach Five are: Frogger Mode Evening EyeThe functions on this Mach Five are: (*)New functions are represented with Bold Italics. Control A = Jump Jacks (Originally called the Auto Jacks) When pressed, the car releases and immediately retracts long automated car jacks that make the car jump over any hazardous obstacle. | https://en.wikipedia.org/wiki/Mach_Five |
Former student David Morrison described Sagan as "an 'idea person' and a master of intuitive physical arguments and 'back of the envelope' calculations", and Gerard Kuiper said that "Some persons work best in specializing on a major program in the laboratory; others are best in liaison between sciences. Dr. Sagan belongs in the latter group. "Sagan's contributions were central to the discovery of the high surface temperatures of the planet Venus. In the early 1960s no one knew for certain the basic conditions of Venus' surface, and Sagan listed the possibilities in a report later depicted for popularization in a Time Life book Planets. | https://en.wikipedia.org/wiki/Carl_Sagan |
Hokora/hokura (神庫) is an extremely small shrine of the kind one finds for example along country roads. Jingū (神宮) is a shrine of particularly high status that has a deep relationship with the Imperial household or enshrines an Emperor, as for example in the case of the Ise Jingū and the Meiji Jingū. The name Jingū alone, however, can refer only to the Ise Jingū, whose official name is just "Jingū". | https://en.wikipedia.org/wiki/Shinto_shrines |
Parallel to the other two components of the program is professional development (PD). These are a series of workshops that concentrate on various soft skills to round out the curriculum, e.g. presentation skills, project management, and teamwork. These workshops prepare USI students for life in the professional sector. Since the USI program's emphasis is on working in industry, PD empowers USI students to be capable managers as well as designers, to make them more competitive players in the job market. | https://en.wikipedia.org/wiki/User_System_Interaction |
For example, within Buddhism, the intention of the individual and the circumstances should be accounted for in the form of Merit, to determine if an action is right or wrong termed. A further disparity between the values of religious traditions is pointed out by Barbara Stoler Miller, who states that, in Hinduism, "practically, right and wrong are decided according to the categories of social rank, kinship, and stages of life. For modern Westerners, who have been raised on ideals of universality and egalitarianism, this relativity of values and obligations is the aspect of Hinduism most difficult to understand".Religions provide different ways of dealing with moral dilemmas. | https://en.wikipedia.org/wiki/Moral_principle |
A 32-bit key sequence is presented on PGD. Voltage is reapplied to MCLR.A separate piece of hardware, called a programmer is required to connect to an I/O port of a PC on one side and to the PIC on the other side. A list of the features for each major programming type are: Parallel port - large bulky cable, most computers have only one port and it may be inconvenient to swap the programming cable with an attached printer. | https://en.wikipedia.org/wiki/In-System_Programming |
According to ancient Greek mythology, Gaia – the Greek goddess and mother of the Titans – gave a sickle made of the strongest metal to her youngest son Kronos, who is also the youngest of the Titans and god of the harvest, to seek vengeance against her husband Ouranos for torturing their eldest sons. The Grim Reaper is often depicted carrying or wielding a scythe. According to Jack Herer and Flesh of The Gods (Emboden, W. A. | https://en.wikipedia.org/wiki/Scythe |
Marriage between higher castes and the kauwa was strictly forbidden. The kauwa worked for the chiefs and were often used as human sacrifices at the luakini heiau. (They were not the only sacrifices; law-breakers of all castes or defeated political opponents were also acceptable as victims. )The kapu system was abolished during the ʻAi Noa in 1819, and with it the distinction between the kauwā slave class and the makaʻāinana (commoners). The 1852 Constitution of the Kingdom of Hawaii officially made slavery illegal. | https://en.wikipedia.org/wiki/Slave_traders |
137 has been the subject of psychological speculation by Swiss psychiatrist and psychoanalyst Carl Jung concerning his theory of synchronicity. Jung and physicist Wolfgang Pauli, according to the book Jung, Pauli, and the Pursuit of a Scientific Obsession by Arthur I. Miller, Emeritus Professor of History and Philosophy of Science at University College London, Jung and Pauli struggled in their search for a primal number that everything in the world hinges on, as well as a desire to quantify the unconscious. | https://en.wikipedia.org/wiki/137_(number) |
The Yde Girl was put on display and further study was not carried out on the remains until 1992. Richard Neave, of University of Manchester, took a CT scan of the skull of Yde Girl and determined her age, both anatomically and historically. The Yde Girl became internationally known when Neave made a reconstruction of her head, using techniques from plastic surgery and criminal pathology. Due to the state of the body, the work on the reconstruction included some guesswork, for example, the nose and some other facial features. | https://en.wikipedia.org/wiki/Yde_Girl |
Research on language MOOCs, and related technology and methodology, offer ways to address some of these challenges, motivating students and implicating them more fully in learning activities related to the development of their second language competences. Furthermore, as the nature of society changes, then so to will the way in which online language learning is undertaken. | https://en.wikipedia.org/wiki/Language_MOOC |
The physical properties of water and heavy water differ in several respects. Heavy water is less dissociated than light water at given temperature, and the true concentration of D+ ions is less than H+ ions would be for a light water sample at the same temperature. The same is true of OD− vs. OH− ions. | https://en.wikipedia.org/wiki/Heavy_water_production |
INOX Air Products, also known as INOX AP, is the India-based industrial gas company. It is a joint venture between Inox Leasing and Finance Limited and Air Products & Chemicals. The company is engaged in the manufacturing, trading, and supply of industrial and medical gases including oxygen, nitrogen, argon, hydrogen, helium, nitrous oxide, acetylene, and specialty gas mixtures. | https://en.wikipedia.org/wiki/Inox_Air_Products |
{\displaystyle {\pmod {\beta }}.} If ( α β ) m = 1 {\displaystyle \left({\frac {\alpha }{\beta }}\right)_{m}=1} then α {\displaystyle \alpha } may or may not be an m-th power ( mod β ) . {\displaystyle {\pmod {\beta }}.} | https://en.wikipedia.org/wiki/Eisenstein_reciprocity |
Trajectories that use ballistic capture are also known as a Low energy transfer (LET). More precisely, the terminology ballistic capture transfer (BCT) is used. They are low energy because they use no delta-V for capture. However, a low energy transfer need not be a ballistic capture transfer. | https://en.wikipedia.org/wiki/Ballistic_capture_orbit |
The idea of the hyperreal system is to extend the real numbers R to form a system *R that includes infinitesimal and infinite numbers, but without changing any of the elementary axioms of algebra. Any statement of the form "for any number x ..." that is true for the reals is also true for the hyperreals. For example, the axiom that states "for any number x, x + 0 = x" still applies. The same is true for quantification over several numbers, e.g., "for any numbers x and y, xy = yx." | https://en.wikipedia.org/wiki/Nonstandard_real_number |
Koritos/Korytos or Koryton (Greek: Κορυτός/Κορυτόν; Macedonian: Коритос / Коритон) was a medieval city-fortress on the road Skopje - Strumica away one day walk from Skopje, North Macedonia. The Arab geographer al-Idrisi mentions the city as Kurta. The city is mentioned only in two sources from the 12th and 13th centuries, and is identified with Ovče Pole's Ǵurište. Some historians believe that this city was actually Kratovo, and that this is actually the name of the medieval city. == Sources == | https://en.wikipedia.org/wiki/Koritos |
SFS appears three times per year (March, July, and November) and averages 200 pages in length. A representative issue contains 5–8 articles ranging in length from 5,000 to 15,000 words, 2–3 review-essays, two dozen book reviews covering scholarly works, plus a substantial Notes and Correspondence section. Special issues follow the same format but are usually guest-edited. Recent special issue topics include Technoculture and Science Fiction, Afrofuturism, Latin American Science Fiction, Animal Studies and Science Fiction, Science Fiction and Sexuality, Italian Science Fiction, Digital Science Fiction, and Spanish Science Fiction, among others. | https://en.wikipedia.org/wiki/Science_Fiction_Studies |
The masses of these bosons are far greater than the mass of a proton or neutron, which is consistent with the short range of the weak force. In fact, the force is termed weak because its field strength over any set distance is typically several orders of magnitude less than that of the electromagnetic force, which itself is further orders of magnitude less than the strong nuclear force. The weak interaction is the only fundamental interaction that breaks parity symmetry, and similarly, but far more rarely, the only interaction to break charge–parity symmetry. | https://en.wikipedia.org/wiki/Weak_decay |
An AAV9 vector is currently used in an FDA-approved gene therapy of spinal muscular atrophy (SMA) in infants and children. The Gray Lab at UTSW initiated a proof of concept mice model study to determine efficacy of this approach for PDCD on November 1, 2022, the Hope for PDCD Foundation is currently raising funds to support this research. Current status of PDHA1 research: PDHA1 can be expressed in cells that are missing the protein, showing that gene therapy could be a viable approach for this disease AAV technology is used to deliver and express PDHA1. Newer version of AAV can effectively target the Central Nervous System (CNS) and skeletal muscles at lower doses than the first generation AAVs. Mouse models with PDH deficiency already exist to easily test this AAV9 approach in vivo AAV9 vectors have been used as FDA-approved gene therapy for SMA, one example of many AAVs currently being investigated for gene therapy approachesProposed preclinical research to clear FDA approval for a first-in-human clinical trial: Test AAV9 efficacy in PDH deficient mouse model and show improvement in disease Provide data on efficacy and toxicity to FDA to get fast-track review for a first-in-human clinical trial | https://en.wikipedia.org/wiki/Pyruvate_dehydrogenase_deficiency |
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