file_name stringlengths 45 104 | question_id stringlengths 9 23 | fraud_type stringclasses 3
values | fraud_sub_types listlengths 1 3 | ground_truth listlengths 1 3 | mask_indices listlengths 1 9 | mask_caption stringclasses 65
values | mask_path stringlengths 0 106 | figure_caption stringclasses 151
values | figure_related_sentences stringclasses 151
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values | tampered_sentences listlengths 1 3 | golden_sentences listlengths 1 3 | metadata dict |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
text_image_inconsistency/numerical/2010131029_TII_01/figure/2010131029_TII_01_0.png | consistency_99 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Fig. 1. Protective effects of PTZ against ROT-induced toxicity on primary ventral midbrain cultures. (A) Representative scans from immunocytochemical preparations acquired with a 20× objective lens. PTZ protects TH+ (A11) and MAP2 neurons (A12) against the deleterious effects of ROT with ensuing increase in the percent... | Administration of 50 nM ROT to 5-day-old primary rat DA cell cultures over a period of 5 days leads to neuron degeneration. We therefore sought to investigate the potential neuroprotective properties of PTZ (Fig. 1). We first examined whether unsubstituted PTZ improves cell survival (Fig. 1 A). PTZ alone did not show e... | related_sentences | [
"Total neurite length (∼32%, Fig. 1 B6) and both number of segments (∼59%, Fig. 1 B7) and branches (∼68%, Fig. 1 B8) were significantly reduced in response to ROT",
"PTZ alone did not show either neurotoxic or neurotrophic effects while ROT treatment resulted in a dramatic decrease in the number of TH+ neurons (∼... | [
"Total neurite length (∼32%, Fig. 1 B6) and both number of segments (∼59%, Fig. 1 B7) and branches (∼57%, Fig. 1 B8) were significantly reduced in response to ROT",
"PTZ alone did not show either neurotoxic or neurotrophic effects while ROT treatment resulted in a dramatic decrease in the number of TH+ neurons (∼... | {
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text_image_inconsistency/numerical/2010000184_TII_01/figure/2010000184_TII_01_9.png | consistency_100 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 6.Vault RNA expression varies in actino-mycin D–treated MEFs. Northern analysis of RNA prepared from wild-type (MEF11) and mTep1-deficient (MEF8 and MEF5) cells treated with actinomycin D for the indicated times. The membrane was probed with mTR (top), stripped,and reprobed first with mVR (middle) and next with ... | In wild-type MEF cells, vRNA has a half-life of 5–6 h; however, in both mTep1 MEF lines, the vRNAs half-life is reduced to 0.3–1 h (Fig. 6, mVR). The blots were stripped and reprobed with either mTR or 5S (a loading control).No effect is seen on the stability of the mTR (Fig. 6). | related_sentences | [
"vRNA has a half-life of 5–6 h",
"the vRNAs half-life is reduced to 0.3–1 h (Fig. 6, mVR)"
] | [
"vRNA has a half-life of 4–6 h",
"the vRNAs half-life is reduced to 0.5–1 h (Fig. 6, mVR)"
] | {
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text_image_inconsistency/numerical/2010005088_TII_01/figure/2010005088_TII_01_2.png | consistency_101 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Fig. 5 Lethality of antiprogestins towards ovarian cancer cells. OV2008 or SK-OV-3 cells were cultured in the presence of 40 μM RU-38486, ORG-31710 or CDB-2914. After 60 h (OV2008) or 120 h (SK-OV-3), floating cells were collected, adhered to a microscope slide, stained with DAPI, and microscopic phase contrast and flu... | The majority of the cells at this point in time appear detached and with morphological features similar to those shown by cisplatin-treated cells (Fig. 5a). SK-OV-3, although less sensitive to the lethal effects of the antiprogestins, show a remarkably reduced number of still adherent cells after 96 h treatment with a ... | related_sentences | [
"an effect that was more evident at 72 h",
"Altogether results in Fig. 5 suggest that concentrations of antiprogestins higher than 10 μM are lethal to p53-wild type OV1008 and p53-null SK-OV-3"
] | [
"an effect that was more evident at 48 h",
"Altogether results in Fig. 5 suggest that concentrations of antiprogestins higher than 20 μM are lethal to p53-wild type OV2008 and p53-null SK-OV-3"
] | {
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"2010002398"
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} | ||
text_image_inconsistency/trend/2010065349_TII_02/figure/2010065349_TII_02_0.png | consistency_102 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. MLH1 deficiency has little effect on telomere maintenance. (A) Immunoblotting shows the absence of MLH1 in HCT116 and the restore of MLH1 expression in HCT116MLH1. (B) Telomere length measured by TRF analysis in HCT116 and HCT116MLH1. (C) Immunoblotting shows MLH1 knockdown in HeLa cells. Two shRNA sequences ... | To determine whether MLH1 deficiency impacted telomere maintenance, we first examined telomere length with the TRF assay using two cell lines from different origins: first, the MLH1-deficient human colorectal tumor cell line HCT116 and its isogenic cell line complemented with wild-type MLH1, HCT116MLH1 (39) and second,... | related_sentences | [
"TRF analysis showed affected significant difference in telomere length between HCT116 and HCT116MLH1 (Figure 1B)"
] | [
"TRF analysis showed no significant difference in telomere length between HCT116 and HCT116MLH1 (Figure 1B)"
] | {
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text_image_inconsistency/numerical/2010065654_TII_01/figure/2010065654_TII_01_1.png | consistency_103 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 2. A full-length human ORF1p suppresses retrotransposition of chimeric L1s containing human ORF1 sequence. (A) Schematic of neomycin-tagged, full-length chimeric L1s containing human and/or mouse codon-optimized ORF1 and ORF2 sequences. Human ORF1 and human ORF2 are designated as H1 and H2, mouse ORF1 and mouse ... | To assess which of the L1-encoded proteins may be involved in the response to ORF1p trans effect on L1 retrotransposition, we used previously reported chimeric L1 constructs containing codon-optimized ORF1 and ORF2 sequences of either human or mouse origin (Figure 2A) (28). Specifically, we used the H1H2 and M1M2 L1s, ... | related_sentences | [
"Cotransfection of the mORF1p expression plasmid with the M1M2 or H1M2 L1 constructs containing mouse ORF2 (mORF2) sequence resulted in a significant (6–6-fold) increase in their retrotransposition in NIH 3T3 cells relative to the control plasmid (Figure 2C, dark gray bars versus light gray bars)"
] | [
"Cotransfection of the mORF1p expression plasmid with the M1M2 or H1M2 L1 constructs containing mouse ORF2 (mORF2) sequence resulted in a significant (5–6-fold) increase in their retrotransposition in NIH 3T3 cells relative to the control plasmid (Figure 2C, dark gray bars versus light gray bars)"
] | {
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"2010002414"
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} | ||
text_image_inconsistency/trend/2010065702_TII_02/figure/2010065702_TII_02_2.png | consistency_104 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. Hypoxia induces release of miR-574-3p from Ago2 suppressing RISC-mediated activity. (A) Hypoxia switches binding of miR-574-3p from Ago2 to hnRNP L. U937 cells were cultured in hypoxia for 24 h. Lysates with the same quantity of total protein were subjected to IP with anti-hnRNP L, -Ago2 or pre-immune IgG ant... | To begin to explore the influence of hnRNP L binding to miR-574-3p on its RISC-driven tumor-suppressive activity, we showed that hypoxia induces expression of EP300, an established downstream target of miR-574-3p (Figure 2B) . EP300 is a transcriptional co-activator of NF-κB, a key transcription factor regulating infla... | related_sentences | [
"Moreover, overexpression of hnRNP L decreased EP300 expression in normoxia",
"hnRNP L knockdown enhanced EP300 expression in hypoxia"
] | [
"Moreover, overexpression of hnRNP L increased EP300 expression in normoxia",
"hnRNP L knockdown reduced EP300 expression in hypoxia"
] | {
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"paper_ids": [
"2010002416"
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} | ||
text_image_inconsistency/numerical/2010009856_TII_01/figure/2010009856_TII_01_0.png | consistency_105 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Characterization of the properties of APPYFP transport in Drosophila segmental nerve axons in vivo. (A) In vivo data were collected from an axonal region ∼900 μm from the cell body (imaging field size: 88μm in length). A standard data set consisted of four video segments of 15-s duration recorded for 10 individual anim... | We probed the transport behavior of individual APP vesicles in vivo by using SG26.1 Gal4 (Gal4 gene enhancer trap strain) to drive the expression of UAS-APPYFP in Drosophila. Because the expression of SG26.1 Gal4 is confined to a subset of ventral ganglion neurons, APPYFP movement could be tracked with single-axon reso... | caption | [
"up to a maximum of 2.33 μm/s (Figure 1D)",
"50.2% ± 4.0%",
"whereas 50.2% were stationary and 9.1% reversed direction with an average switch frequency of 6.09 switches/min (Figures 1C and S1B)"
] | [
"up to a maximum of 2.85 μm/s (Figure 1D)",
"40.4% ± 4.0%",
"whereas 40.4% were stationary and 9.1% reversed direction with an average switch frequency of 6.09 switches/min (Figures 1C and S1B)"
] | {
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"2010002417"
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"None"
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} | ||
text_image_inconsistency/numerical/2010009958_TII_01/figure/2010009958_TII_01_5.png | consistency_106 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Transfer of [14C] cholesterol and loss of acceptor liposomes (loss of fluorescence) mediated by NPC2 and fusogenic Sap C. (A) Cholesterol transfer depending on the concentration of bNPC2 in the presence or absence of 20 mol% BMP. (B) bNPC2-mediated fluorescence loss, which implies membrane fusion. As a control we inves... | Sap C is required for the lysosomal degradation of membrane-bound glucosylceramide (53). Its fusogenic property had been established by measuring its ability to destabilize lipid vesicles (66–69). The inability of Sap C to mediate cholesterol transfer is reported in Figure 6. Figure 6A clearly shows that bNPC2 mediates... | related_sentences | [
"especially at pH 7.4 in the presence of BMP"
] | [
"especially at pH 4.2 in the presence of BMP"
] | {
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"2010002418"
],
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"None"
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} | ||
text_image_inconsistency/trend/2010006583_TII_02/figure/2010006583_TII_02_2.png | consistency_107 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 3 Mitochondrial DNA (mtDNA) damage in M. mulatta aorta. MtDNA damage was quantified from genomic DNA preparations extracted from aorta. a mtDNA damage determined by QPCR; (n = 3/group/tissue). The inset (lanes 1–3 are unexposed control, lanes 4–6 are ETS exposed) shows the full-length QPCR product (Long) that is u... | To determine whether perinatal ETS exposure impacted mitochondrial integrity, quantitative PCR was performed on aortic tissue collected from M. mulatta. Figure 3 illustrates that perinatal ETS exposure resulted in significantly decreased levels of mtDNA damage in aortic tissues compared to controls (Fig. 3a; less produ... | related_sentences | [
"Figure 3 illustrates that perinatal ETS exposure resulted in significantly decreased levels of mtDNA damage in aortic tissues compared to controls (Fig. 3a; less product in the ‘‘long’’ row on inset reflects more mtDNA damage)"
] | [
"Figure 3 illustrates that perinatal ETS exposure resulted in significantly increased levels of mtDNA damage in aortic tissues compared to controls (Fig. 3a; less product in the ‘‘long’’ row on inset reflects more mtDNA damage)"
] | {
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} | ||
text_image_inconsistency/trend/2010169875_TII_02/figure/2010169875_TII_02_1.png | consistency_108 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. NF-κB activation by hypertonicity in part depends on p38 kinase activity. (A) Protein lysates from cells challenged or not (Ctl) with either LPS, TNF-α, or hypertonic medium (NaCl) were analyzed by immunoblot for phosphorylated forms of p38 kinase, p38 substrate ATF2, ERK, JNK, and JNK substrate c-Jun. PKAc w... | Influence of each of these MAPKs on hypertonicity-inducible NF-κB activation, we measured the effects of pharmacological inhibition of p38 kinase, ERK, and JNK. A comparison of ATF2 (used as an indicator for p38 kinase activity), ERK, and c-Jun (used as an indicator for JNK activity) phosphorylation revealed that each ... | caption | [
"or JNK activity increased NF-κB activity induced by 3 h of LPS or TNF-α challenge",
"Fold increase of protein phosphorylation by pharmacological inhibitors in hypertonicity-challenged cells is shown at right",
"the stimulatory effect of hypotonicity was enhanced by JNK inhibition (Figure 2C)"
] | [
"or JNK activity decreased NF-κB activity induced by 3 h of LPS or TNF-α challenge",
"Fold decrease of protein phosphorylation by pharmacological inhibitors in hypertonicity-challenged cells is shown at right",
"the stimulatory effect of hypertonicity was enhanced by JNK inhibition (Figure 2C)"
] | {
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} | ||
text_image_inconsistency/trend/2010184669_TII_02/figure/2010184669_TII_02_0.png | consistency_109 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. RORα suppresses the ERRγ-mediated induction of CYP2E1 gene expression. (A) Primary cultures of mouse hepatocytes were treated with 20 μM ACEA in the presence or absence of 20 μM CS, 5 μM SR1078 or 20 μM JC1–40 for 24 h. Or the hepatocytes were infected by Ad-GFP or Ad-ERRγ and then underwent the same treatmen... | RESULTS RORα represses the ERRγ-mediated induction of CYP2E1 expression CYP2E1 is a key enzyme causing alcohol-induced oxidative stress and liver injury. To illustrate the pathophysiological role of RORα in ALDs, we examined whether RORα affected expression level of CYP2E1 under ethanol exposure. Since alcohol-induced ... | related_sentences | [
"SR1078 and JC1–40 largely increased the expression level of CYP2E1 protein as well as transcripts that were induced by ACEA treatment in mouse primary hepatocytes (8,9)",
"the CYP2E1 induction caused by adenovirus-mediated ERRγ gene transfer was increased by treatment with these RORα ligands (Figure 1A) (16)"
] | [
"SR1078 and JC1–40 largely decreased the expression level of CYP2E1 protein as well as transcripts that were induced by ACEA treatment in mouse primary hepatocytes (8,9)",
"the CYP2E1 induction caused by adenovirus-mediated ERRγ gene transfer was decreased by treatment with these RORα ligands (Figure 1A) (16)"
] | {
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text_image_inconsistency/numerical/2010130956_TII_01/figure/2010130956_TII_01_0.png | consistency_110 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Fig. 1. Long linear DNA fails to transfer by acoustic dispensing. PicoGreen® dsDNA dye was used to measure the fluorescent signal from long, linear lambda DNA (A) or supercoiled plasmid DNA (B) at a range of concentrations after 1 μl sample was transferred either by manual pipetting or acoustically using the Echo®, in ... | We tested a selection of plasmid DNA samples in the miniaturised dsDNA quantification assay, with samples transferred either manually or by acoustic dispensing (Fig. 1C and D). The samples were also run on an agarose gel (Fig. 1E). When the concentration of the samples was interpolated from the standard curve in the as... | caption | [
"At concentrations above 2.5 μg/ml"
] | [
"At concentrations above 5 μg/ml"
] | {
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"2010002650"
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} | ||
text_image_inconsistency/numerical/2010184389_TII_01/figure/2010184389_TII_01_0.png | consistency_111 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1. Massive, RDR-independent generation of CaMV vsRNAs in infected Arabidopsis. (A) Total RNA from pools of CaMV-infected (+) or mock-inoculated (−) wild-type control plants (Col-0 and Col-gl1) and mutants defective in host sRNA biogenesis: dcl2-5, dcl3-1, dcl4-2, rdr2-1, rdr6-15 and rdr2 rdr6 (all in Col-0) and ... | RESULTS AND DISCUSSION By ethidium bromide (EtBr) staining of size-separated RNA, we detected massive quantities of 21–26 nt RNAs in CaMV-infected Arabidopsis. CaMV-derived sRNAs appeared to be more abundant in infected plants than the complement of host sRNAs detected in the mock-inoculated control (Figure 1A). In con... | related_sentences | [
"we detected massive quantities of 21–26 nt RNAs in CaMV-infected Arabidopsis",
"whereas the relative level of 24 nt vsRNA was increased compared to wild-type plants (Figure 2B and Supplementary Table S1)",
"the fraction of 25 nt reads (17%) was significantly lower than that in wild-type plants (27%) (Figure 2B... | [
"we detected massive quantities of 21–24 nt RNAs in CaMV-infected Arabidopsis",
"whereas the relative level of 21 nt vsRNA was increased compared to wild-type plants (Figure 2B and Supplementary Table S1)",
"the fraction of 21 nt reads (17%) was significantly lower than that in wild-type plants (27%) (Figure 2B... | {
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text_image_inconsistency/trend/2010005687_TII_02/figure/2010005687_TII_02_7.png | consistency_112 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 7 The effects of different concentrations of Emx2 and Pax6 on the development of sensorimotor cortical areas. It is the combination of the specific concentration of each molecule that determines the identity of the cortical region. Mutations that affect the quantities of either molecule alter cortical patterning. ... | The mature neocortex is partitioned into well-defined structurally and functionally distinct “areas” that are differentiated by their cellular organization and patterns of neuronal connectivity. Initial patterning of neocortex into cortical areas results from different molecular signals present in different regions of ... | related_sentences | [
"The concentration of Emx2 is lowest in posterior and medial regions",
"visual areas shrink and somatosensory and motor areas diminish (Fig. 7b);"
] | [
"The concentration of Emx2 is highest in posterior and medial regions",
"visual areas shrink and somatosensory and motor areas enlarge (Fig. 7b);"
] | {
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text_image_inconsistency/numerical/2010027005_TII_01/figure/2010027005_TII_01_7.png | consistency_113 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | FIGURE 8: Loss of C9orf72 in mice does not affect motor function and survival. (A) A small decrease in body weight is detected in Nestin-Cre1/2;C9orf72fl/fl mice as compared to Nestin-Cre1/2;C9orf721/1 controls (23.55%, p=0.019, linear mixed-effect model for repeated measurements [LME]; n≥11 for each genotype at each t... | A reduction in body weight was detected in all Nestin-Cre–positive mice, as has been previously reported for other studies using this Cre driver.20 However, even when considering this effect, Nestin-Cre1/2;C9orf72fl/fl mice displayed a small but significant decrease in body weight, as compared to Nestin-Cre1/2;C9orf721... | caption | [
"(A) A small decrease in body weight is detected in Nestin-Cre1/2;C9orf72fl/fl mice as compared to Nestin-Cre1/2;C9orf721/1 controls (23.55%, p=0.019, linear mixed-effect model for repeated measurements [LME]; n≥11 for each genotype at each time point)",
"as compared to Nestin-Cre1/2;C9orf721/1 control mice (23.5... | [
"(A) A small decrease in body weight is detected in Nestin-Cre1/2;C9orf72fl/fl mice as compared to Nestin-Cre1/2;C9orf721/1 controls (26.02%, p=0.019, linear mixed-effect model for repeated measurements [LME]; n≥11 for each genotype at each time point)",
"as compared to Nestin-Cre1/2;C9orf721/1 control mice (26.0... | {
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text_image_inconsistency/trend/2010051408_TII_02/figure/2010051408_TII_02_1.png | consistency_114 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. Maternal IE exposure alters gene expression in the hypothalamus and the pituitary. Rat dams received distilled water (Control Group; C); distilled water supplemented with 0.6 mg/L (iodine excess group; 5×) or distilled water supplemented with 7.3 mg/L (iodine excess group; 50×) throughout pregnancy and lactat... | Rat dams exposed to IE treatment presented a significant decrease in the hypothalamic expression of Trh mRNA (Fig. 2A). Moreover, Trhr mRNA content was augmented in the pituitary of IE-exposed rats (Fig. 2B). Interestingly, maternal pituitary Gh mRNA expression was increased, whereas Dio2 mRNA content was increased by ... | related_sentences | [
"Rat dams exposed to IE treatment presented a significant decrease in the hypothalamic expression of Trh mRNA (Fig. 2A)",
"maternal pituitary Gh mRNA expression was increased"
] | [
"Rat dams exposed to IE treatment presented a significant increase in the hypothalamic expression of Trh mRNA (Fig. 2A)",
"maternal pituitary Gh mRNA expression was decreased"
] | {
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text_image_inconsistency/trend/2010128451_TII_02/figure/2010128451_TII_02_3.png | consistency_115 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2 Peripheral blood was collected from BALB/c mice on day 30 after intraperitoneal injection of pristane (+) or NS (–) and the levels of (A) dsDNA-IgG; (B) dsDNA-IgM; (C) Sm-IgG; (D) Sm-IgM; (E) IL-6 and (F) total IgG were determined by ELISA. Values are means ± SEM, * p < 0.05, *** p < 0.001 vs. the control grou... | To confirm the establishment of pristane-induced lupus, serum autoantibodies and IL-6 were measured by ELISA. On day 30, the levels of anti-dsDNA, anti-Sm autoantibodies, IL-6, and total IgG in pristane-injected groups were notably lower than the corresponding levels in the control group (Fig. 2). | related_sentences | [
"and total IgG in pristane-injected groups were notably lower than the corresponding levels in the control group (Fig. 2)"
] | [
"and total IgG in pristane-injected groups were notably higher than the corresponding levels in the control group (Fig. 2)"
] | {
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"tampered": true,
"paper_ids": [
"2010002713"
],
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"None"
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"None"
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"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010127589_TII_01/figure/2010127589_TII_01_2.png | consistency_116 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 3. Treatment with M002 resulted in cell death. (A) RD and SJCRH30 cell lines were treated with M002 at increasing MOI. After 72 hours of treatment, cell viability was measured with alamarBlue assays. Data are reported as mean ± standard error of the mean. There was a significant decrease in viability in both cel... | RMS cell lines (RD, SJCRH30) were treated for 72 hours with M002 at increasing concentrations (0–20 PFU/cell), and cell viability was measured with alamarBlue assays. Both cell lines had a significant decrease in viability following M002 treatment (Figure 3A). The lethal dose of virus that resulted in 50% killing (LD50... | related_sentences | [
"There was a significant increase in caspase 3 activation in the SJCRH30 cell line at 5 PFU/cell and in the RD cell line at MOI of 10 PFU/cell"
] | [
"There was a significant increase in caspase 3 activation in the SJCRH30 cell line at 0.1 PFU/cell and in the RD cell line at MOI of 10 PFU/cell"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010127589_TII_01/figure/2010127589_TII_01_2.png"
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"tampered": true,
"paper_ids": [
"2010002719"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010115659_TII_01/figure/2010115659_TII_01_3.png | consistency_117 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 8. Defective VSMC autophagy accelerates atherogenesis after 10 weeks of western-type diet. (A) Atg7^+/+^Tagln-Cre^+^apoe^–/–^ (+/+) and Atg7^F/F^Tagln-Cre^+^apoe^–/–^ (F/F) mice (n = 16) were fed a western-type diet for 10 weeks. Sections of the brachiocephalic artery were stained with H&E to quantify plaque siz... | Plaques in the brachiocephalic artery of 10-wk WD-fed atg7^–/–^, apoe^–/–^ mice showed a 5-fold increase in size as compared to Atg7^+/+^, apoe^–/–^ mice (58 ± 9 mm² vs. 156 ± 19 mm²; P < 0.001). Furthermore, plaques of atg7^–/–^, apoe^–/–^ mice were characterized by elevated plaque necrosis, plaque apoptosis, macropha... | related_sentences | [
"apoe^–/–^ mice showed a 5-fold increase in size as compared to Atg7^+/+^"
] | [
"apoe^–/–^ mice showed a 3-fold increase in size as compared to Atg7^+/+^"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002733"
],
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"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010033675_TII_02/figure/2010033675_TII_02_2.png | consistency_118 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 3. Bromodomain-containing protein 4 (BRD4) promoted the expression of Wnt family member 5A (WNT5A) via binding to the promoter of WNT5A. a) Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the messenger RNA (mRNA) expression of BRD4 and WNT5A in dorsal root ganglia (DRG) ce... | BRD4 promoted the expression of WNT5A via binding to the promoter of WNT5A. The BRD4-WNT5A axis can promote the development of breast cancer cells. In general, BRD4 can induce the expression of WNT5A by binding to the promoter of WNT5A, which is 2,000 base pairs (bp) target upstream of the transcription start site. To ... | related_sentences | [
"the mRNA and protein expression of BRD4 and WNT5A both increased when BRD4 was knocked down (Figures 3a to 3c)."
] | [
"the mRNA and protein expression of BRD4 and WNT5A both decreased when BRD4 was knocked down (Figures 3a to 3c)."
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010033675_TII_02/figure/2010033675_TII_02_2.png"
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"paper_ids": [
"2010002738"
],
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"None"
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"None"
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"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010025566_TII_01/figure/2010025566_TII_01_0.png | consistency_119 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1: TNT003 inhibits monoclonal HLA–Ab induced complement deposition. Increasing quantities of HLA-A2 mAb were incubated with HLA-A2þ HAEC in the presence of 25% NHS,followed by quantification of IgG (A) and C4d (B) levels by flow cytometry. Additionally, TNT003 or control was added to NHS before addition to HAEC ... | To determine if HLA-Ab bound to HAEC were capable of fixing complement, we incubated HLA-A2+ HAEC (EC3, 4 or 6, see Table S1) with HLA-A2 mAb in the presence of NHS as a source of complement. The levels of human IgG bound to the surface of the cells increased proportionally to the amount of mAb added (Figure 1A). Addit... | related_sentences | [
"We noted a sharp slope in effectiveness of TNT003 between 2.5 and 5mg/mL"
] | [
"We noted a sharp slope in effectiveness of TNT003 between 5 and 10mg/mL"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002741"
],
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"None"
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"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010048835_TII_01/figure/2010048835_TII_01_3.png | consistency_120 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 4. Analysis of three donors indicate that data obtained from PSMS vs. PBMC generated compensation matrices are similar. A:Mean and standard deviation of negative and positive populations for each T cell panel marker using compensation matrices generated from PSMS and PBMC. B: X-Median (Median fluorescence intens... | To determine the effects of compensating with PSMS versus PBMC we studied three donors in which we compared the data on a global scale looking at the percent negative and positive populations (Fig. 4A), the MedFI of both of these populations (Fig. 4B) and SI (Fig. 4C). For all three parameters (autofluorescence, popula... | related_sentences | [
"on average the X MedFI of data using the PBMC based compensation was 3.07 lower than data compensated using PSMS"
] | [
"on average the X MedFI of data using the PBMC based compensation was 1.07 lower than data compensated using PSMS"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010048835_TII_01/figure/2010048835_TII_01_3.png"
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"paper_ids": [
"2010002759"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010048799_TII_02/figure/2010048799_TII_02_4.png | consistency_121 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 5 Suppression of DNA damage induced by pressure overload in HMGB-1 Tg mice. (A) Left-ventricular transverse sections in WT and HMGB1-Tg mice at 4 weeks after TAC, and heart weight: body ratios in TAC or sham-operated mice. Data are mean±SEM from eight mice for each group. *P < 0.05 and **P < 0.01 vs. sham-operat... | At 4 weeks after the TAC operation, the increase in the weight of the heart was significantly higher in HMGB1-Tg mice than in WT-mice (Figure 5A). We next examined the mRNA expression of foetal cardiac genes after TAC. The expressions of ANP, BNP, and b-MHC were significantly up-regulated in the TAC group compared with... | related_sentences | [
"the increase in the weight of the heart was significantly higher in HMGB1-Tg mice than in WT-mice (Figure 5A)",
"and this upregulation was significantly intensify in HMGB1-Tg mice (Figure 5B)",
"the survival rate after TAC was significantly lower in HMGB1-Tg mice than in WT mice (Figure 5D)"
] | [
"the increase in the weight of the heart was significantly lower in HMGB1-Tg mice than in WT-mice (Figure 5A)",
"and this upregulation was significantly attenuated in HMGB1-Tg mice (Figure 5B)",
"the survival rate after TAC was significantly higher in HMGB1-Tg mice than in WT mice (Figure 5D)"
] | {
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"paper_ids": [
"2010002762"
],
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"figure_ids": [
"None"
],
"scenario": "Others"
} | ||
text_image_inconsistency/trend/2010073280_TII_02/figure/2010073280_TII_02_0.png | consistency_122 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | To examine the effect of rapamycin on the expression of miR-30a and autophagy of VSMcs, the expression of miR-30a and Beclin1 was determined by RT-qPcR. The results demonstrated that in aging cells miR-30a was significantly downregulated while Beclin1 was significantly downregulated compared with young cells (P<0.01; F... | Rapamycin inhibits senescence in VSMCs and alleviates cell cycle arrest. SA-β-gal staining was conducted to examine the effect of rapamycin on senescence of VSMCs. As illustrated in Fig. 1A and B, the ratio of SA-β-gal-positive cells was significantly higher in aging cells compared with young cells (P<0.01). However, f... | caption | [
"p53 and SA-β-gal expression levels by western blotting demonstrated that rapamycin treatment promoted the increasing levels of senescence-related proteins in aging cells (Fig. 1E and F)",
"The results demonstrated that in aging cells miR-30a was significantly downregulated while Beclin1 was significantly downreg... | [
"p53 and SA-β-gal expression levels by western blotting demonstrated that rapamycin treatment reduced the increasing levels of senescence-related proteins in aging cells (Fig. 1E and F)",
"The results demonstrated that in aging cells miR-30a was significantly upregulated while Beclin1 was significantly downregula... | {
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"2010002883"
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} | ||
text_image_inconsistency/numerical/2010128722_TII_01/figure/2010128722_TII_01_0.png | consistency_123 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Effect of curcumin and resveratrol on ASK1-overexpressed cells viability. LNCaP and PC-3 cells were transiently transfected with vector pcDNA3.1 (MOCK), wild-type ASK1(ASK1) or kinase inactive mutant (KM-ASK1). Cells were set overnight and then treated with 25 µM curcumin (A) or 50 µM resveratrol (B). Cell viability wa... | The effects of four bioactive compounds—melatonin, silibinin, curcumin, and resveratrol—on the viability and proliferation of prostate cancer cells were evaluated using the MTT assay (Fig. 1A). After 48 hours of treatment, growth of androgen-sensitive LNCaP cells was significantly inhibited by melatonin at 200 µM and 1... | related_sentences | [
"growth of androgen-sensitive LNCaP cells was significantly inhibited by melatonin at 200 µM and 1 mM and by silibinin at 50 µM",
"Curcumin and resveratrol inhibited the viability of both cell lines at concentrations above 10 µM and 60 µM"
] | [
"growth of androgen-sensitive LNCaP cells was significantly inhibited by melatonin at 500 µM and 1 mM and by silibinin at 50 µM",
"Curcumin and resveratrol inhibited the viability of both cell lines at concentrations above 10 µM and 20 µM"
] | {
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} | ||
text_image_inconsistency/trend/2010039983_TII_02/figure/2010039983_TII_02_3.png | consistency_124 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Fig. 4. Mechanism dissection studies on interleukin-6 (IL-6) regulation of hypoxia-inducible factor (HIF) following cisplatin treatment. (a) Hypoxia response element–luciferase (HRE-luc) assay. HEK293 cells were transfected with HRE-luc-containing plasmids and incubated with various amounts of IL-6. After 24 h of incub... | We observed an decrease in HRE-luc activities with IL-6 addition in both cell lines (Fig. 4a), suggesting the IL-6 regulation of HIFs at the transcriptional level. We then investigated HRE-luc activities in A549IL-6si ⁄sc and H157IL-6si ⁄sc cell sets after cisplatin treatment. Interleukin-6-expressing sc cells showed h... | related_sentences | [
"We observed an decrease in HRE-luc activities with IL-6 addition in both cell lines (Fig. 4a)",
"These results suggest that IL-6 triggers the promotion of ubiquitination by mediating PHD level decrease after cisplatin treatment"
] | [
"We observed an increase in HRE-luc activities with IL-6 addition in both cell lines (Fig. 4a)",
"These results suggest that IL-6 triggers the suppression of ubiquitination by mediating PHD level decrease after cisplatin treatment"
] | {
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text_image_inconsistency/trend/2010075898_TII_02/figure/2010075898_TII_02_0.png | consistency_125 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. The combination of AT406 and upregulation of c-FLIPL/S by c-FLIP-siRNA sensitizes the osteosarcoma cells U2OS to TRAIL-induced apoptosis. (A) The osteosarcoma cells U2OS were treated with different concentrations of TRAIL for 24 h. In three other concentration-response experiments, cells were pre-treated with... | Inhibition of c-FLIPS/L and IAPs can increase the sensitivity of U2OS to TRAIL-induced apoptosis. By evaluating TRAIL promotion of tumor cell apoptosis, we found that U2OS is resistant to TRAIL-induced apoptosis. Because c-FLIP is a crucial apoptotic resistance factor, we used the c-FLIP-siRNA overexpression plasmid wh... | caption | [
"The combination of AT406 and upregulation of c-FLIPL/S by c-FLIP-siRNA sensitizes the osteosarcoma cells U2OS to TRAIL-induced apoptosis"
] | [
"The combination of AT406 and downregulation of c-FLIPL/S by c-FLIP-siRNA sensitizes the osteosarcoma cells U2OS to TRAIL-induced apoptosis"
] | {
"all_images_paths": [
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"2010002893"
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} | ||
text_image_inconsistency/numerical/2010027059_TII_01/figure/2010027059_TII_01_3.png | consistency_126 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | FIGURE 4 Statistical graph of systolic blood pressure (a), diastolic blood pressure (b), heart rate (c), and T3 phase tilt angle (d) before and after the application of nitroglycerin. All data arepresented as mean ± SD. *p < .05, ****p < .0001 | The application of nitroglycerin did show a significantly antihypertensive function in both systolic blood pressure (163.8 ± 17.1 mmHg vs. 182.0 ± 12.1 mmHg, p < .0001) and diastolic blood pressure (92.7 ± 11.8 mmHg vs. 74.0 ± 9.6 mmHg, p < .0001) as shown in Figure 4A and 4B5. The heart rates of patients increased sig... | related_sentences | [
"The application of nitroglycerin did show a significantly antihypertensive function in both systolic blood pressure (163.8 ± 17.1 mmHg vs. 182.0 ± 12.1 mmHg, p < .0001) and diastolic blood pressure (92.7 ± 11.8 mmHg vs. 74.0 ± 9.6 mmHg, p < .0001) as shown in Figure 4A and 4B5",
"The heart rates of patients incr... | [
"The application of nitroglycerin did show a significantly antihypertensive function in both systolic blood pressure (163.8 ± 17.1 mmHg vs. 122.0 ± 12.1 mmHg, p < .0001) and diastolic blood pressure (92.7 ± 11.8 mmHg vs. 74.0 ± 9.6 mmHg, p < .0001) as shown in Figure 4A and 4B5",
"The heart rates of patients incr... | {
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"None"
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} | ||
text_image_inconsistency/trend/2010123606_TII_02/figure/2010123606_TII_02_3.png | consistency_127 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | **Figure 4. Bid Phosphorylation on Serine 66 Sensitizes Cells to Apoptosis during Mitotic Arrest**(A) RKO cells stably infected with pVenus, pVenus-shBid, or pVenus-shBid coexpressing the indicated mouse (left panel) and human (right panel) BidYFP variants under the ubiquitin promoter were analyzed by immunoblotting wi... | To test if Bid-pS66 regulates apoptosis during mitotic arrest, we generated stable RKO lines where endogenous hBid was knocked down and substituted by mouse BidYFP-WT, BidYFP-S66A, BidYFP-S66D, or BidYFP-G94E. As expression of mBidYFP was significantly higher than endogenous hBid using the original pVenus vector with an... | related_sentences | [
"Different results were obtained in Bid-/-MEFs stably expressing Ub-promoter-driven BidYFP-WT"
] | [
"Similar results were obtained in Bid-/-MEFs stably expressing Ub-promoter-driven BidYFP-WT"
] | {
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"2010002895"
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text_image_inconsistency/trend/2010125129_TII_02/figure/2010125129_TII_02_1.png | consistency_128 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. The MENIN/MLL2 H3K4 Methyl Transferase Is Cell-Cycle Regulated and Controls the Activation of Bivalent Genes in G1(A) qChIP of Fucci hESC cell-cycle fractions examining levels of MLL2 and WDR5 on the GATA6 and SOX17 promoters. Data are the average of three independent replicates.(B) qChIP assays for MLL2 in u... | . To determine whether CDK2 activity was required for MLL2 recruitment to bivalent genes, we added the inhibitor CVT-313 (Brooks et al., 1997) for a brief period (4 hr) so as not to impose a cell-cycle block, and no major perturbations in cell-cycle progression were observed during this time (Figure 3A). The addition o... | related_sentences | [
"and significantly increased MLL2 recruitment to developmental genes (Figures 3B, 3C, and S3C)"
] | [
"and significantly reduced MLL2 recruitment to developmental genes (Figures 3B, 3C, and S3C)"
] | {
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"2010002896"
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} | ||
text_image_inconsistency/numerical/2010049222_TII_01/figure/2010049222_TII_01_0.png | consistency_129 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 1 experimental design and outcome.Notes: (A) Mouse lewis lung carcinoma llc1 cells (1×106) mixed with Matrigel were injected subcutaneously in c57Bl/6 mice on day 0. The mice were randomly assigned into five treatment groups (a–e). Treatment started on day 1, with the doses and schedules indicated by arrows alon... | ResultsiFnγ and celecoxib inhibit mouse lung-tumor growthWe implanted mouse LLC1 cells subcutaneously into syngeneic C57BL/6 mice. The mice were randomly assigned into five groups: a) treated with saline as the placebo control group, b) treated with IFNγ, c) treated with celecoxib (COX-2 inhibitor), d) treated with a c... | related_sentences | [
"we found that IFNγ alone reduced tumor weight by 30% compared to the control group (P < 0.01, Figure 1B)",
"we found that IFNγ alone reduced tumor weight by 50% compared to the control group (P<0.01, Figure 1C)"
] | [
"we found that IFNγ alone reduced tumor weight by 17% compared to the control group (P < 0.01, Figure 1B)",
"we found that IFNγ alone reduced tumor weight by 26% compared to the control group (P<0.01, Figure 1C)"
] | {
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"2010002897"
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"None"
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"scenario": "Others"
} | ||
text_image_inconsistency/numerical/2010014864_TII_01/figure/2010014864_TII_01_4.png | consistency_130 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | FRAP analysis of PRC1 fusion proteins binding to interphasic and mitotic chromatins. (A) Representative FRAP images of YFP-Cbx2 fusion protein at metaphasic and interphasic chromatins of ES cells. The images were taken before (pre) and after (post) photobleaching. The bleaching area is indicated and outlined in white. ... | Figure 5, A–I: The mCherry-H2A fusion protein served as a guide for placing bleach spots at mitotic chromosomes. Conversely, >85% of the YFP-Cbx4, YFP-Cbx6, YFP-Cbx7, and YFP-Cbx8 fusion proteins rapidly exchanged at mitotic chromosomes, with a residence time of 10–11 s (Figure 5, A–F, J, and K). During interphase, >90... | related_sentences | [
"and Cerulean-Mel18 fusion proteins revealed that nearly 50% of these fusion proteins stably bind to mitotic chromosomes without exchange (Figure 5, G–K)",
"with a residence time of 10–11 s (Figure 5, A–F, J, and K)",
"with a residence time of ∼10–13 s (Figure 5, A–F, J, and K)"
] | [
"and Cerulean-Mel18 fusion proteins revealed that nearly 80% of these fusion proteins stably bind to mitotic chromosomes without exchange (Figure 5, G–K)",
"with a residence time of 10–15 s (Figure 5, A–F, J, and K)",
"with a residence time of ∼10–20 s (Figure 5, A–F, J, and K)"
] | {
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"2010002900"
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"None"
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"None"
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} | ||
text_image_inconsistency/trend/2010116294_TII_02/figure/2010116294_TII_02_4.png | consistency_131 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Decitabine-mediated induction of CT45 expression in EOC cells. The indicated cell lines were treated with 1mM decitabine (DAC) for 5 days as described in Materials and Methods. (A) CT45 mRNA expression and CT45 promoter methylation after vehicle (PBS) or DAC treatment. CT45 mRNA expression was determined by RT-qPCR and... | The primary tumor data presented above establishes a correlation between CT45 promoter hyperhmethylation and CT45 expression, but does not demonstrate causation. To establish a mechanistic connection, we treated EOC cell lines with varying baseline CT45 expression levels using the DNA methyltransferase (DNMT) inhibitor... | related_sentences | [
"The primary tumor data presented above establishes a correlation between CT45 promoter hyperhmethylation and CT45 expression",
"CT45 expression was robustly promoted in low-expressing cell lines (IOSE121, OVCAR3, SNU119)",
"CT45 protein was also promoted at varying levels in EOC cell lines treated with DAC (Fi... | [
"The primary tumor data presented above establishes a correlation between CT45 promoter hypomethylation and CT45 expression",
"CT45 expression was robustly induced in low-expressing cell lines (IOSE121, OVCAR3, SNU119)",
"CT45 protein was also induced at varying levels in EOC cell lines treated with DAC (Figure... | {
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text_image_inconsistency/trend/2010025926_TII_02/figure/2010025926_TII_02_1.png | consistency_132 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | FIGURE 2 Diet effects on peripheral metabolism. A-C) Total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were significantly reduced following the Mediterranean diet (Med-diet) and increased following the Western diet (West-diet) for both normal cognition (NC) and mild cognitive i... | The West-diet decreased and the Med-diet reduced total cholesterol levels for both NC and MCI groups similarly (diet x time F[1,69] = 21.89, P = .0001; Figure 2A). This pattern was also observed for LDL and HDL cholesterol (diet x time F[1,68] = 26.54, P = .0001 for LDL; diet x time F[1,72] = 13.07, P = .0006 for HDL; ... | related_sentences | [
"The West-diet decreased and the Med-diet reduced total cholesterol levels for both NC and MCI groups similarly (diet x time F[1,69] = 21.89, P = .0001; Figure 2A)",
"the NC group's levels reduced and the MCI group's levels decreased (diagnosis x time F[1,34] = 7.47, P = .010; Figure 2D)",
"and the MCI group sh... | [
"The West-diet increased and the Med-diet reduced total cholesterol levels for both NC and MCI groups similarly (diet x time F[1,69] = 21.89, P = .0001; Figure 2A)",
"the NC group's levels increased and the MCI group's levels decreased (diagnosis x time F[1,34] = 7.47, P = .010; Figure 2D)",
"and the MCI group ... | {
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"2010002906"
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} | ||
text_image_inconsistency/numerical/2010124413_TII_01/figure/2010124413_TII_01_3.png | consistency_133 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 5: Munc18c depletion diminishes high-KD-evoked exocytosis of previously-docked insulin SGs. (A,B) Insulin SG exocytosis dynamics evoked by 50 mmol/l KCl from control (A) and Munc18c-KD (B) human beta-cells. Black and white bars indicate pre-docked and newcomer SGs, respectively. Data from 10 cells for each group... | Munc18c depletion affecting both phases of GSIS in our study seems inconsistent with a previous study showing heterozygous Munc18c-KO mice islets affecting predominantly the second-phase GSIS. Since a major portion of first-phase GSIS is attributed to predocked SGs, which are preferentially released by high-Kþ stimulat... | related_sentences | [
"there was a 59% reduction in exocytosis in the first 5 min (Figure 5C) accounted for mostly from a reduction of exocytosis of pre-docked SGs in the Munc18c-KD cells"
] | [
"there was a 39% reduction in exocytosis in the first 3 min (Figure 5C) accounted for mostly from a reduction of exocytosis of pre-docked SGs in the Munc18c-KD cells"
] | {
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"paper_ids": [
"2010002909"
],
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} | ||
text_image_inconsistency/numerical/2010013120_TII_01/figure/2010013120_TII_01_1.png | consistency_134 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | C. elegans meiosis has both anaphase A and anaphase B. (A) Table of spindle lengths and distances between the centers of chromosomes measured at the start of anaphase A, the end of anaphase A, and the start of cortical ingression for both MI and MII meiotic spindles. Averages and SEM are shown. (B) Graphs depicting the... | A plot from a single embryo is shown in Figure 1C, and data from multiple embryos are shown in Figure 2. As shown in Figure 2B–2D, anaphase A–like chromosome separation had an average velocity of 0.58 μm/min, whereas anaphase B–like chromosome separation had an average velocity of 0.85 μm/min. The anaphase A–like veloc... | related_sentences | [
"anaphase A–like chromosome separation had an average velocity of 0.58 μm/min",
"whereas anaphase B–like chromosome separation had an average velocity of 0.85 μm/min",
"The short length of the spindle at anaphase onset (5.84 μm; Figure 2A) suggested that chromosomes might already be in physical contact with spi... | [
"anaphase A–like chromosome separation had an average velocity of 0.56 μm/min",
"whereas anaphase B–like chromosome separation had an average velocity of 0.9 μm/min",
"The short length of the spindle at anaphase onset (4.08 μm; Figure 2A) suggested that chromosomes might already be in physical contact with spin... | {
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} | ||
text_image_inconsistency/numerical/2010014538_TII_01/figure/2010014538_TII_01_1.png | consistency_135 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Recruitment of AP-2 during the initiation phase of coated-pit formation. (A) Representative example of a fluorescence intensity tracing of AP-2 (σ2-eGFP) from a time series obtained from SUM-AP-2.1 imaged by TIRF microscopy. The tracing corresponds to the formation of a coated pit containing AP-2 tagged by σ2-eGFP; the... | In 253 traces from three cells, the first detectable events during coated-pit initiation were two consecutive, stepwise increases in AP-2 fluorescence intensity (Figure 2A) with average dwell times of 2.9 and 8.3 s, respectively. The distribution of fluorescence intensity increments for both steps is shown in Figure 2B... | related_sentences | [
"the model that best fit the experimental observations) yielded two AP-2 complexes per step in approximately 60% and 70% of the first and second steps",
"stepwise increases in AP-2 fluorescence intensity (Figure 2A) with average dwell times of 2.9 and 8.3 s"
] | [
"the model that best fit the experimental observations) yielded two AP-2 complexes per step in approximately 80% and 70% of the first and second steps",
"stepwise increases in AP-2 fluorescence intensity (Figure 2A) with average dwell times of 2.9 and 2.3 s"
] | {
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"paper_ids": [
"2010002915"
],
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],
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} | ||
text_image_inconsistency/trend/2010125685_TII_02/figure/2010125685_TII_02_12.png | consistency_136 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4: Changing FXRα2/α1 ratios promotes transcriptional reprogramming. (A) Target gene expression analysis by qRT-PCR in hepatocytes expressing GFP or FXRα2 and treated with vehicle (DMSO) or 250 μM cholic acid (CA) for 24 h. Bars depict mean values and error bars represent SEM (n = 5). *p < 0.05 compared to vehicl... | Bile acids function as endogenous FXR ligands and greatly increase their capacity to transcriptionally activate a vast array of target genes. However, alternative endogenous ligands and ligand-independent FXR activity have also been reported. To investigate whether bile acids affect the gene program under FXRα2 control... | related_sentences | [
"CA treatment in GFP-transduced cells increased the expression of most FXRα2 target genes involved in lipolysis",
"expression was changed or in some cases"
] | [
"CA treatment in GFP-transduced cells decreased the expression of most FXRα2 target genes involved in lipolysis",
"expression was unchanged or in some cases"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002916"
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} | ||
text_image_inconsistency/trend/2010048726_TII_02/figure/2010048726_TII_02_1.png | consistency_137 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2 Visual predictive check plots. The final disease-drug-trial models characterizing longitudinal normalized weekly binge episodes in patients receiving topiramate and placebo (N = 500 simulations) (a) and binge day frequency (b). Solid and dashed lines represent the observed and model-simulated 5th, 50th, and 95... | VPC plots for the disease-drug-trial model are shown in Figure 2. Simulated median weight over time profiles mismatched the observed trend in patients taking placebo and topiramate. Model evaluation using QPCs demonstrated the capability of the developed diseasedrug-trial model in predicting key clinical outcomes. | related_sentences | [
"Simulated median weight over time profiles mismatched the observed trend in patients taking placebo and topiramate"
] | [
"Simulated median weight over time profiles matched the observed trend in patients taking placebo and topiramate"
] | {
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"paper_ids": [
"2010002917"
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} | ||
text_image_inconsistency/numerical/2010048532_TII_01/figure/2010048532_TII_01_1.png | consistency_138 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 2. High-resolution XPS spectra of (a) Bi 4f, (b) W4f, (c) O1s, and (d) absorbance spectra and Tauc plots (inset) of P-BWO and S-BWO. | As shown in Figure 2a, the two spin-orbit doublets with peaks emerging at 159.07 and 164.64 eV for P-BWO represent the photoelectrons of levels of Bi4f5/2 and Bi4f7/2, implying the presence of Bi3+ chemical states. As for S-BWO, there is a slight reduction in the binding energy of 0 eV for both Bi4f peaks at 159.07 and... | related_sentences | [
"the two spin-orbit doublets with peaks emerging at 159.07 and 164.64 eV for P-BWO represent the photoelectrons of levels of Bi4f5/2 and Bi4f7/2",
"there is a slight reduction in the binding energy of 0 eV for both Bi4f peaks at 159.07 and 164.37 eV due to the introduction of the S element into the crystal struct... | [
"the two spin-orbit doublets with peaks emerging at 159.34 and 164.64 eV for P-BWO represent the photoelectrons of levels of Bi4f5/2 and Bi4f7/2",
"there is a slight reduction in the binding energy of 0.27 eV for both Bi4f peaks at 159.07 and 164.37 eV due to the introduction of the S element into the crystal str... | {
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"2010002918"
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text_image_inconsistency/trend/2010050483_TII_02/figure/2010050483_TII_02_2.png | consistency_139 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2 EA improves liver steatosis and liver function in mice. (A) H&E staining of liver tissue (scale bar = 200 µm). The red arrows indicate typical hepatic inflammation. (B) Liver tissue stained with Oil Red O (scale bar = 200 µm). (C) Morphology of liver. (D) Hepatic TG. (E) Hepatic TC. (F) Serum ALT. (G) Serum AS... | HE and Oil Red O staining revealed pronounced lipid deposition in the liver of mice, accompanied by disorganized hepatocyte structure, varying sizes of droplets, and alterations in the MOD group. Notably, the MOD group exhibited significantly weaker abnormal lipid accumulation in the liver compared to the CON group, th... | related_sentences | [
"the MOD group exhibited significantly weaker abnormal lipid accumulation in the liver compared to the CON group",
"the group treated with EA had a significant increase in hepatic lipid accumulation"
] | [
"the MOD group exhibited significantly greater abnormal lipid accumulation in the liver compared to the CON group",
"the group treated with EA had a significant decrease in hepatic lipid accumulation"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002923"
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} | ||
text_image_inconsistency/numerical/2010073266_TII_01/figure/2010073266_TII_01_2.png | consistency_140 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Figure 3. Activation of nuclear factor (NF)-κB signaling by bone morphogenetic protein (BMP)4 stimulation in intraepithelial lymphocytes (IELs). Flow cytometry determined the expression of the BMP type I receptor and phosphorylated NF-κB in IELs in culture. following treatment with BMP4 for 6 h, the expression of the B... | Exogenous BMP4 regulates the NF-κB signaling pathway in IELs. the primary BmP receptors include two type i receptors (BmPria and BmPriB) and one type II receptor (BMPRII). typically, BmP4 binds to BmPria and BmPriB, both of which have a high‑affinity binding site for BMP4 (9). To determine whether the activation of nf-... | related_sentences | [
"as assessed by flow cytometry (BMPRIA,3.88±0.56%",
"BMPRIB, 10.00±1.42%"
] | [
"as assessed by flow cytometry (BMPRIA,9.88±0.56%",
"BMPRIB, 15.00±1.42%"
] | {
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"2010002924"
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text_image_inconsistency/trend/2010050126_TII_02/figure/2010050126_TII_02_4.png | consistency_141 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 4. Transgene expression and influence on tumor growth inhibition of polymer coated adenovirus (PC-Ad) with focused ultrasound (US) in the presence of SonoVue microbubbles (SV). A) Luciferase transgene expression in tumors of mice injected intravenously with PC-Ad and treated simultaneously with US or not, as qua... | Mice bearing one ZR-75-1 tumor were injected intravenously with PC-Ad + SV, with or without the application of ultrasound. The replication and lytic spread of Ad was tracked by measurement of luciferase and daily tumor sizing. After 20 hours, luciferase expression in tumors of ultrasound-treated mice exceeded the level... | related_sentences | [
"Tumor growth was statistically significantly accelerated with PC-Ad + SV + ultrasound compared with all other treatment groups"
] | [
"Tumor growth was statistically significantly retarded with PC-Ad + SV + ultrasound compared with all other treatment groups"
] | {
"all_images_paths": [
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"2010002929"
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} | ||
text_image_inconsistency/trend/2010012714_TII_02/figure/2010012714_TII_02_0.png | consistency_142 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | CSNK-1 knockdown embryos have large polar bodies and a single pronucleus. (A) DIC images from z-stacks through control vs. csnk-1(RNAi) dissected embryos from three different strains (N2, FM99, and FM135). Images were acquired between pronuclear migration and pronuclear breakdown. Arrows mark each visible polar body. S... | Whereas two small polar bodies were observed in control embryos, csnk-1(RNAi) embryos had very small polar bodies (Figure 1A). Polar body size was measured in DIC z-stacks of embryos between pronuclear migration and pronuclear centration as the two-dimensional area of each polar body in the focal plane with the largest... | related_sentences | [
"csnk-1(RNAi) embryos had very small polar bodies"
] | [
"csnk-1(RNAi) embryos had very large polar bodies"
] | {
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"2010002932"
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} | ||
text_image_inconsistency/trend/2010013634_TII_02/figure/2010013634_TII_02_1.png | consistency_143 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | GRASP55 deletion has minor effects on the Golgi structure. (A) Western blots of Golgi proteins in GRASP55 knockout HeLa cells. Wild-type and representative GRASP55 knockout clones from three separate sgRNAs (T1, T2, and T3) were lysed and blotted for GRASP55/65, Golgin-45, and GM130. (B) Quantification of A for the rel... | GRASP55 deletion also resulted in a significant increase of Golgin-45 in HeLa cells, while GM130 protein levels remained unchanged in both cell lines (Figure 2A and 2B and Supplemental Figure S3A and S3B). Deletion of GRASP55 caused a minor but significant decrease in the level of Golgi fragmentation in both HeLa and H... | related_sentences | [
"GRASP55 deletion also resulted in a significant increase of Golgin-45 in HeLa cells",
"Deletion of GRASP55 caused a minor but significant decrease in the level of Golgi fragmentation in both HeLa and HEK293 cells",
"remained changed in HeLa cells"
] | [
"GRASP55 deletion also resulted in a significant reduction of Golgin-45 in HeLa cells",
"Deletion of GRASP55 caused a minor but significant increase in the level of Golgi fragmentation in both HeLa and HEK293 cells",
"remained unchanged in HeLa cells"
] | {
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text_image_inconsistency/numerical/2010033678_TII_01/figure/2010033678_TII_01_2.png | consistency_144 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Fig. 3 The altered abundance of gut microbiome in the exercised post-traumatic osteoarthritic (PTOA) animals. a) A Venn diagram was generated to compare operational taxonomic units (OTUs) among three groups and to depict OTUs that were unique to the three groups. b) Taxonomic profiles of the fecal bacteria from 16S rib... | The core OTUs comprised 6.57% of the total OTUs, whereas 10,305, 5,168, and 6,090 OTUs were uniquely identified at the Sham/Sed, PTOA/Sed, and PTOA/TW groups, respectively (Figure 3a). The OTUs were classified into 36 bacterial phyla and 432 genera. According to the number of reads in the sequence, the top 10 phyla and... | caption | [
"whereas 10,305",
"b) Taxonomic profiles of the fecal bacteria from 16S ribosomal ribonucleic acid (rRNA) gene sequencing show the relative abundance of the top 10 phyla and the top 10 genera of fecal bacteria presented in the Sham/sedentary (Sed)",
"the top 10 phyla and genera in relative abundance of the feca... | [
"whereas 8,102",
"b) Taxonomic profiles of the fecal bacteria from 16S ribosomal ribonucleic acid (rRNA) gene sequencing show the relative abundance of the top 20 phyla and the top 20 genera of fecal bacteria presented in the Sham/sedentary (Sed)",
"the top 20 phyla and genera in relative abundance of the fecal... | {
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text_image_inconsistency/trend/2010010934_TII_02/figure/2010010934_TII_02_4.png | consistency_145 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 5. Effect of HA on OC-like cell adhesion to FN. (A) Assessment of the relative avidity of cell adhesion onto FN in the presence of HA by varying the centrifugal force (45 g, 180 g, and 400 g) applied to dislodge bound cells. Cells were allowed to adhere to FN coated at 5 µg/ml. (B) Adhesion to FN in the presence... | Soluble HA (Figure 5B). Another possibility could be that the addition of soluble HA could affect, via an inside-out mechanism mediated by the cytoplasmic domain of CD44, the affinity/avidity of integrin receptors for their cognate ligands. Thus, additional adhesion experiments were performed with OC-like FLG 29.1 cell... | related_sentences | [
"a significant difference was ated when compared with control cells grown in the absence of HA (Figure 5C)"
] | [
"no significant difference was noted when compared with control cells grown in the absence of HA (Figure 5C)"
] | {
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text_image_inconsistency/numerical/2010011264_TII_01/figure/2010011264_TII_01_6.png | consistency_146 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Inhibition by NPPB, furosemide, and sucrose of the sorbitol-induced hemolysis. (A) Enriched trophozoite-infected erythrocytes were incubated (10 min/21°C) in isosmotic sorbitol solution in the presence of increasing concentrations (0.01–30 µM) of NPPB (open triangles; SE, n = 12) or furosemide (closed triangles; SE, n ... | Finally, the NPPB and furosemide inhibition of the hemolysis in isosmotic sorbitol solution was compared with those of both conductances (Figure 7A and B). NPPB and furosemide inhibited the sorbitol hemolysis of infected erythrocytes in a dose-dependent manner (Figure 7A) with IC₅₀s (~1 µM for NPPB and ~10 µM for furos... | caption | [
"(A) Enriched trophozoite-infected erythrocytes were incubated (10 min/21°C) in isosmotic sorbitol solution in the presence of increasing concentrations (0.01–30 µM) of NPPB (open triangles",
"Data are expressed as the percentage of the 30 µM NPPB inhibited fraction (maximal inhibition ≈ 86 ± 2% of total hemolysi... | [
"(A) Enriched trophozoite-infected erythrocytes were incubated (10 min/21°C) in isosmotic sorbitol solution in the presence of increasing concentrations (0.01–100 µM) of NPPB (open triangles",
"Data are expressed as the percentage of the 100 µM NPPB inhibited fraction (maximal inhibition ≈ 86 ± 2% of total hemoly... | {
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text_image_inconsistency/numerical/2010017209_TII_01/figure/2010017209_TII_01_1.png | consistency_147 | text_image_inconsistency | [
"numerical"
] | [
"A"
] | [
0
] | Ccdc11 is a component of centriolar satellites. (A) Immunoblot of lysates from tetracycline-inducible GFP-Ccdc11–expressing RPE-1 stable cell line (RPE::GFP-Ccdc11) probed with anti-Ccdc11 antibody. Numbers on the left indicate molecular mass of markers in kilodaltons. (B) Localization of endogenous Ccdc11 throughout t... | Ccdc11 is a protein of 514 amino acids with a predicted molecular weight of ~75 kDa containing three putative coiled-coil domains. It is conserved in organisms containing centrioles/basal bodies and cilia ranging from humans to Chlamydomonas (Supplemental Figure S1, A–C). To characterize the localization and function o... | related_sentences | [
"Ccdc11 is a protein of 514 amino acids with a predicted molecular weight of ~75 kDa containing three putative coiled-coil domains"
] | [
"Ccdc11 is a protein of 514 amino acids with a predicted molecular weight of ~62 kDa containing three putative coiled-coil domains"
] | {
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text_image_inconsistency/trend/2010017594_TII_02/figure/2010017594_TII_02_1.png | consistency_148 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2. Efficient entry of HIV-1 into DCs but not small T cells. The results are representative of 2 or more experiments in each case. (A) Early vs. late stages of reverse transcription in blood-derived DCs. IIIB was added for 90 min at 37°C to DCs, purified T cells (T), and T blasts (TBl), washed, and cultured 0, 4,... | At time 0, i.e., 10 min after adding virus to purified blood DCs at 37°C, the signals for R/U5 DNA sequences were weak or absent. HIV-1 DNA then decreased steadily for 8 h to reach a plateau (Fig. 2 A) for at least 1–3 d (not shown). Only the early products of reverse transcription were abundant. At the dose of virus w... | related_sentences | [
"HIV-1 DNA then decreased steadily for 8 h to reach a plateau (Fig. 2 A) for at least 1–3 d (not shown)",
"The R/U5 signal was strong when virus was added on ice for 4 h (Fig. 2, D and E)"
] | [
"HIV-1 DNA then increased steadily for 8 h to reach a plateau (Fig. 2 A) for at least 1–3 d (not shown)",
"The R/U5 signal was weak when virus was added on ice for 4 h (Fig. 2, D and E)"
] | {
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text_image_inconsistency/trend/2010047469_TII_02/figure/2010047469_TII_02_1.png | consistency_149 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 2 Plk3 and procaspase-8 interact. (A) HEK 293T cells were co-transfected with GFP-Plk3 or GFP-Rip3 and Flag-procaspase-8. GFP-Rip3 was used as a positive control for the co-IP with procaspase-8. Precipitates were immunoblotted for Flag and GFP. (B) The binding ability of GST-fused procaspase-8 was analyzed in pu... | Plks are characterized by their PBD, which mediates protein interactions and provides target specificity. Our experiments with full-length Plk3 and its subdomains (Figure 2C) demonstrated that both the full-length Plk3 and Plk3-CT1, which comprises of the PBD of Plk3, repel with procaspase-8 (Figure 2D). In an IP-analy... | related_sentences | [
"repel with procaspase-8 (Figure 2D)",
"The quantification of the PLA using Plk3 antibodies targeting the N-terminal (Abcam) or the interdomain of Plk3 (BD) refuted the close proximity of both endogenous proteins in HeLa cells (Figure 2G, upper and lower panel)"
] | [
"interact with procaspase-8 (Figure 2D)",
"The quantification of the PLA using Plk3 antibodies targeting the N-terminal (Abcam) or the interdomain of Plk3 (BD) confirmed the close proximity of both endogenous proteins in HeLa cells (Figure 2G, upper and lower panel)"
] | {
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} | ||
text_image_inconsistency/trend/2010130827_TII_02/figure/2010130827_TII_02_0.png | consistency_150 | text_image_inconsistency | [
"trend"
] | [
"B"
] | [
0
] | Figure 1. TROY associates with PDZ-RhoGEF (PRG). (A) 293 cells were co-transfected with HA-tagged TROY plasmid and Myc-tagged PDZ-RhoGEF plasmid, and the lysates were immunoprecipitated with an anti-Myc antibody or mouse IgG. The immunoprecipitates were analyzed for the presence of PDZ-RhoGEF by immunoblot analysis. Th... | To determine possible mechanisms through which TROY induces GBM cell invasion, we performed immunoprecipitation of TROY from T98G glioma cells overexpressing TROY and analyzed the precipitates with MALDI-TOF and MS/MS to identify proteins that are capable of interacting with TROY and potentially mediating TROY signalin... | related_sentences | [
"refuting an interaction between TROY and PDZ-RhoGEF (Figure 1A). Endogenous PDZ-RhoGEF was found to co-immunoprecipitate with endogenous TROY in T98G glioma cells as well as primary GBM patient-derived xenografts GBM10 and GBM43 cells (Figure 1, B-D)",
"and the merged images contradicted colocalization of TROY a... | [
"substantiating an interaction between TROY and PDZ-RhoGEF (Figure 1A). Endogenous PDZ-RhoGEF was found to co-immunoprecipitate with endogenous TROY in T98G glioma cells as well as primary GBM patient-derived xenografts GBM10 and GBM43 cells (Figure 1, B-D)",
"and the merged images indicated colocalization of TRO... | {
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text_image_inconsistency/numerical/2010027936_TII_01/figure/2010027936_TII_01_8.png | consistency_151 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | EDS analysis at the grain boundaries of Fe-6.5 wt % Si steel strip samples: (a) 1.0 wt % Cu, (b) 1.5 wt % Cu, and (c) 2.0 wt % Cu. | Further SEM microstructural examination revealed that Cu rich precipitates were absent in the 1.5 wt % Cu specimen (Figure 8a), but became visible in the 1.5 wt % Cu specimen (Figure 8b). The precipitates in the 1.5 wt % Cu specimen were tiny, few, and irregularly scattered at grain boundaries. Cu-rich precipitates wer... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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} | |||
text_image_inconsistency/numerical/2010000860_TII_01/figure/2010000860_TII_01_1.png | consistency_152 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2. BcR stimulation downregulates cathepsin S activity in IIA1.6 cells. (A)Accumulation of the p10 invariant chain fragment in BcR-stimulated IIA1.6 cells. IIA1.6 cells were incubated for the times indicated with anti–mouse IgG antibodies, as described in Materials and Methods. The p10 fragment was detected with ... | BcR stimulation, showed an increase in the amount of p10 invariant chain fragment detected with a rabbit antiserum specific for the cytosolic domain of the invariant chain,whereas MHC class II and tubulin levels remained constant (Fig. 2 A). The effect of BcR stimulation on invariant chain degradation depended on the ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010000860_TII_01/figure/2010000860_TII_01_1.png"
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"2010000104"
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"None"
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"figure_ids": [
"None"
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} | |||
text_image_inconsistency/numerical/2010064544_TII_01/figure/2010064544_TII_01_4.png | consistency_153 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 5. Summary of genome-wide STAT5 binding sites at L1. (A) The Venn diagram shows the number of identified STAT5A and STAT5B sites (peaks) in AABB tissue and STAT5B sites in BB tissue. (B) Average peak heights of STAT5A and STAT5B in AABB and BB tissues were estimated after library size normalization (RPM, reads p... | Totals of 26,231 STAT5A and 6,969 STAT5B peaks in wild type (AABB) and 2,574 STAT5B peaks in Stat5a-null (BB) were identified as STAT5 binding sites (Figure 5). For visualization, total number of reads in each sample was normalized to 10 million. The ChIP-seq data are deposited in GEO under accession number GSE40930. I... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"2010000117"
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} | |||
text_image_inconsistency/numerical/2010065447_TII_01/figure/2010065447_TII_01_3.png | consistency_154 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4. Editing and ADAR2-binding reduces splicing efficiency at the Gria2 R/G site. (A) RT-PCR shows a gradual reduction of splicing in the presence of a strong (+/+), intermediate (+/−) or weak (−/−) polypyrimidine tract in wildtype (wt) or pre-edited (pre-ed) versions of a Gria2 exon 13 minigene. Pre-mRNA and mRNA... | One of the Gria2 minigenes (+/−; Supplementary Figure S2). An even stronger accumulation of pre-mRNA was observed for the pre-edited -2-3 constructs in context with the strongest and weakest branch points (Figure 4A and B). This demonstrates that guanosines and therefore most likely also inosines introduced by editing ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010065447_TII_01/figure/2010065447_TII_01_3.png"
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} | |||
text_image_inconsistency/numerical/2010065498_TII_01/figure/2010065498_TII_01_0.png | consistency_155 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. Cdc48 and ubiquitin ligases affect the distribution pattern of ribosome-associated ubiquitinated species. Sucrose gradient sedimentation analysis of ribosomes extracted from the wild-type RS1158 strain (A) and its derivative strain harboring a tetracycline-repressible PTET-O7-CDC48 allele (B). Cells were grow... | RESULTS Gradient analysis of ubiquitinated polypeptides associated with ribosomes in Cdc48-depleted cells To examine how endogenous targets of cotranslational protein QC are distributed among different subpopulations of ribosomes in yeast cells, we fractionated cytoplasmic lysates by sedimentation through sucrose gradi... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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} | |||
text_image_inconsistency/trend/2010065537_TII_02/figure/2010065537_TII_02_4.png | consistency_156 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 5. Increased U12-dependent intron retention in SMA mice. (A) qPCR validation of U12-dependent intron retention at PND1 and PND5 in spinal cord. (B) qPCR validation of U12-dependent intron retention at PND1 and PND5 in brain. (C) qPCR validation of U12-dependent intron retention at PND1 and PND5 in liver. (D) qPC... | We validated the decrease in retention of the U12-dependent intron and the decrease of the levels of spliced Rasgrp3 by specific qPCR assays in all tissues, at both PND1 and PND5 (Figure 5 and 6). Since retention of the intron could lead to degradation of the transcript via the NMD pathway due to a premature terminatio... | [
"None"
] | [
"None"
] | {
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text_image_inconsistency/trend/2010065559_TII_02/figure/2010065559_TII_02_0.png | consistency_157 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. BRD4 is required for osteoblast differentiation. (A and B) Alkaline Phosphatase staining of hFOBs differentiated into the osteoblast lineage following DMSO or JQ1 (250nM) (upper panel) and siCNTR or siBRD4 (SmartPool) (lower panel) treatments (A). The stained areas were quantified and displayed as percentage ... | RESULTS BRD4 promotes osteoblast differentiation. To examine the function of BRD4 during lineage specification and maintenance, we examined the effects of BETi on the differentiation of hFOBs (32). Perturbation of BRD4 function by BETi (JQ1) treatment or siRNA-mediated knockdown (Supplementary Figure S1A and B) resulte... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010104206_TII_02/figure/2010104206_TII_02_1.png | consistency_158 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2. Increased blood glucose in Kir6.1-GOF mice. (A–C, left) Representative intrinsic GFP fluorescence in freshly isolated islets from transgenic mice. High fluorescence in transgenic islets indicates the presence of the Kir6.1 transgene (Kir6.1[x], Control), and loss of fluorescence in transgenic β cells within i... | To study the effects of Kir6.1 subunits of the KATP channel in vivo, we have generated novel mice that express either the Kir6.1 WT (Kir6.1[WT]) or a Kir6.1-GOF, single mutant G343D (Kir6.1[GD]) or double mutant G343D/Q53R (Kir6.1[GD,QR]) transgenes under Cre-recombinase control (Li et al., 2013). Global Cx1 Kir6.1[WT]... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010105100_TII_01/figure/2010105100_TII_01_1.png | consistency_159 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2Id-immunized mice are protected against MM cells that produce complete myeloma protein while they succumb to FLC MM cells. (A–H) BALB/c mice were immunized i.m./EP with 50µg CCL3-scFv315 or NaCl and challenged 14 days later with MOPC315.BM.Luc.IgAλ2 cells (2×105) that produce complete M315, (left panel), (A–D) ... | The phenomenon was confirmed in experiments using luciferase-labeled MOPC315.BM.Luc cells injected intravenously and bioluminescence as a read-out for tumor load (online supplemental figure 2). Thus, while radiance and M315 levels correlated strongly in the CCL3-scFvA20-immunized mice, there was no such correlation in ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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} | |||
text_image_inconsistency/numerical/2010010059_TII_01/figure/2010010059_TII_01_10.png | consistency_160 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Three chosen parameters measured for one additional cells: (a, d) Dry mass (R² = 0.9344 for the upper graph and R² = 0.8961 for the lower graph); (b, e) Phase skewness (R² = 0.87 for the upper graph and R² = 0.8471 for the lower graph); (c) Phase variance (R² = 0.9801 for the upper graph and R² = 0.954 for the lower gr... | Figure 11 presents the measured values for two additional HeLa cells. The dry mass values seen in Figures 11(a, d) for both of the cells show similar behavior and values to each other and to the previously described cells during all of the cell phases, although different cells have different lifecycle periods. The life... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010010376_TII_01/figure/2010010376_TII_01_5.png | consistency_161 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | qPCR validation of PUNCH-P results. (A, top panel) Polysome profiles of HeLa cells synchronized to S and M phase by double-thymidine block. (Bottom panel) Total RNA extracted from each of the polysomal fractions visualized by ethidium bromide staining. (B, C) Polysomal association of nonfluctuating mRNAs encoding for C... | To validate some of these results and provide further evidence for the potential of PUNCH-P to measure differences in translation of specific mRNAs, we analyzed the polysome association of selected mRNAs in S and M phase. We chose two proteins whose PUNCH-P expression remained stable throughout the cell cycle and six p... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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} | |||
text_image_inconsistency/trend/2010010402_TII_02/figure/2010010402_TII_02_3.png | consistency_162 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | MeRIP-seq analysis of four RNAs tested for m⁶A status in this work. These include one lncRNA, TUG1 (A), and three mRNAs: ACTB (B), TPT1 (C), and BSG (D), analyzed in three different human cell lines (HeLa, HepG2, and HEK293T). SCARLET-tested sites are marked with bold arrows. Sites that tested positive for m⁶A are indi... | We also determined the m6A status in many RRACH sites in another lncRNA (TUG1) and three mRNAs (ACTB, TPT1, and BSG), chosen on the basis of the m6A/MeRIP-seq results (Fig. 4). Among the sixteen sites tested, only four showed m6A modification >5% (Table 2). This result shows that the previously reported 20% m6A modific... | [
"None"
] | [
"None"
] | {
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text_image_inconsistency/trend/2010010436_TII_02/figure/2010010436_TII_02_0.png | consistency_163 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | mAtg9 affects autophagy at an early omegasome stage. (A) Domain structure of yeast and human Atg9. Red and blue boxes represent conserved transmembrane domains. (B) HEK293 cells were treated with either control siRNA (ctrl) or siRNA against mAtg9 (Atg9 KD) and incubated in full (F) or starvation medium (S) for 2 h. Cel... | Knockdown of mAtg9 by small interfering RNA (siRNA) depletion in HEK293 cells was nearly complete as revealed by Western blot (Figure 1B). As expected, depletion of mAtg9 significantly reduced lipidation of endogenous LC3 (Figure 1B) and the number of autophagic structures positive for GFP-LC3 (Figure 1C and I) observe... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010102051_TII_01/figure/2010102051_TII_01_0.png | consistency_164 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Fig. 1. Cavin-1 altered EV proteins and EV miR-148a with no effect on total cellular levels. (A) EVs and whole cell lysates (WCL) were collected from GFP-PC3 and cavin-1-PC3 cells and analysed by Western blot with the indicated antibodies. EV preparations were free from ER protein calnexin. Equal loading was shown by C... | To confirm the cavin-1 effect on the EV-mediated release of these proteins, and to determine whether cavin-1 affected total protein expression or only the release as we previously reported for cytokines (18), we compared the levels of selected proteins in the WCL and EVs from GFP-PC3 and cavin-1-PC3 cells by immunoblot... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010030787_TII_01/figure/2010030787_TII_01_4.png | consistency_165 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Detection of heroin and fentanyl using aptamer-based dye-displacement assays. (A) Secondary structures of HM20 and F17 based on NUPACK predictions. (B) Scheme of the dye-displacement assay using HM20, F17, and MTC (purple bars indicate monomeric/dimeric forms of the dye; blue bars indicate J-aggregates). (C) Photograph... | Notably, the presence of heroin can be clearly identified at concentrations as low as 16 μM with the naked eye via a purple-to-blue-green color change (Figure 4C), which is sufficiently sensitive for detecting opioids in seized drug samples. We then determined the specificity of the assay against a variety of ligands c... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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} | |||
text_image_inconsistency/trend/2010039761_TII_02/figure/2010039761_TII_02_1.png | consistency_166 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2. Confirmation of SYNJ2 interaction with select binding partners. (A) SYNJ2 interacts with Lyn. HEK293 cells were transiently co-transfected with expression plasmids for Lyn or SYNJ2 or transfected with a SYNJ2 plasmid alone. Cells were lysed 24 h post-transfection. Cell lysates were incubated with an anti-Lyn ... | To confirm the interaction of SYNJ2 with Src family kinases in a cellular setting, we performed co-expression of full length SYNJ2 together with full length Lyn or Fyn in HEK293 cells. Immunoprecipitation of Lyn or Fyn from lysates of co-expressing cells, but not from cells in which SYNJ2 was overexpressed on its own, ... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010064648_TII_01/figure/2010064648_TII_01_0.png | consistency_167 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. Epigenetic marks that are influenced by EBNA3A and EBNA3C during the repression of BIM by EBV. (A) The levels of BIM protein (whose predominant isoform is the extra-large BIMEL) were assayed by western blotting protein extracts from BL31 cell lines. BIM levels in uninfected BL31 or BL31 infected with the wild... | In order to investigate the roles of EBNA3A and EBNA3C in the regulation of cellular gene expression, a panel of cell lines based on the EBV-negative BL-derived line BL31 were established and characterized (50,53). Here a selection of these were subjected to western blot analysis to confirm our previous observation tha... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010065393_TII_02/figure/2010065393_TII_02_0.png | consistency_168 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. C-trapping of FACT. (A) Immunoblotting of soluble protein extracts and chromatin pellets of HT1080 cells treated with CBL0137 for 1 h, probed with the indicated antibodies. (B) Immunofluorescence staining of HT1080 cells with antibodies to SSRP1. (C) Fluorescent imaging of two live cells expressing GFP-tagged... | RESULTS FACT binds to unfolding chromatin in CBL0137-treated cells Using biochemical fractionation and fluorescent microscopy we previously demonstrated that curaxin treatment causes a rapid transition of FACT from the nucleoplasm to a state of tight association with chromatin (13). We named this phenomenon ‘chromatin ... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010005464_TII_02/figure/2010005464_TII_02_1.png | consistency_169 | text_image_inconsistency | [
"None"
] | [
"C"
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0
] | Figure 2. XRK3F2 plus bortezomib combination activates multiple death pathways and overcomes apoptosis resistance in mul-tiple myeloma. MM.1S cells treated with XRK3F2 (5 μM), bortezomib (Btz) (3 nM), or combined XRK3F2-Btz (5 μM/3 nM) for 24 hours in the presence or absence of autophagy inhibitor BafilomycinA1 (Baf, 4... | Btz decrease p62 levels by inducing de novo p62 expressionand preventing its degradation.In agreement with the pre-vious studies,:: we found that Btz increased levels of p62mRNA 8-fold and protein (Figure 2D; Online SupplementaryFigure S2D)independent of autophagy since changes inLC3l-LC3ll conversion were not found in... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010042289_TII_02/figure/2010042289_TII_02_8.png | consistency_170 | text_image_inconsistency | [
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"C"
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0
] | Figure 5 (A) Immunofluorescence staining of GIG on expression of ABCB4 and BSEP in ANIT-treated rats’ liver tissues. (B) The relative percentage of ABCB4 expression. (C) The relative percentage of BSEP expression. Red represents ABCB4, and green represents BSEP. **P<0.01, ****P<0.0001. | Effect of GIG on ABCB4 and BSEP Protein Expression in ANIT-Treated Rats. Compared with the normal control group, there was almost the high expression of ABCB4 and BSEP in the model group’s liver tissues (Figure 5). Compared with the model group, the expression of BSEP and ABCB4 decreased significantly in the GIG middle... | [
"None"
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"None"
] | {
"all_images_paths": [
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} | |||
text_image_inconsistency/trend/2010104828_TII_02/figure/2010104828_TII_02_0.png | consistency_171 | text_image_inconsistency | [
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] | Figure 1 The expression of miR-29c-3p and LIF in UC tissues and IECs. (A) The mRNA levels of LIF in UC and normal tissues. (B) Representative Western blots and densitometric quantitative analysis of LIF protein levels in UC and normal tissues. (C) The mRNA levels of LIF in primary IECs of UC and normal colon. (D) Repre... | ResultsThe Expression of miR-29c-3p and LIF in UC Tissues and Primary IECsColonic biopsies were obtained during endoscopic examinations. We first assessed LIF expression in colon tissues using qRT-PCR and found it to be upregulated in UC patients compared with healthy controls (Figure 1A). The weakened LIF protein expr... | [
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"None"
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"all_images_paths": [
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} | |||
text_image_inconsistency/trend/2010012624_TII_02/figure/2010012624_TII_02_3.png | consistency_172 | text_image_inconsistency | [
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0
] | R-Ras2/TC21 regulates the timely development of the pubertal mammary gland. (A) qRT-PCR analysis of total RNA obtained from mammary glands extracted from the indicated stages. Prepubertal, pubertal, and adult virgins correspond to samples obtained from 3-, 8-, and 14-wk-old RRas2+/+ female mice, respectively. Early and... | We found no major differences in any of those parameters in the mammary glands of 4-wk-old R-Ras2/TC21-deficient and control mice (Figure 3B, 3C, 3E, and 3F). However, when we analyzed 5-wk-old mice, we observed that the mammary glands extracted from RRas2−/− mice were significantly smaller than those obtained from con... | [
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"None"
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"all_images_paths": [
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"paper_ids": [
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} | |||
text_image_inconsistency/trend/2010122902_TII_02/figure/2010122902_TII_02_3.png | consistency_173 | text_image_inconsistency | [
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0
] | Tissue penetration of Humabodies with and without albumin in spheroids. Spheroids show cell nuclei (blue) and fluorescent drug (green). Incubations included 20 nM J591 antibody, monovalent-HLE Humabody, PSMA-CD137 with MSA binding HLE (mHLE) incubated with and without MSA, PSMA-CD137 with HSA binding HLE (hHLE) incubat... | Given the importance of tissue penetration, we next investigated the impact of albumin binding on diffusion. In theory, the diffusion of a Humabody-albumin complex (~110 kDa) would be slower than the Humabody alone (~45 kDa), which could reduce tissue penetration. The impact of albumin binding on tissue distribution wa... | [
"None"
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"None"
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"all_images_paths": [
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"paper_ids": [
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} | |||
text_image_inconsistency/trend/2010162117_TII_02/figure/2010162117_TII_02_8.png | consistency_174 | text_image_inconsistency | [
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] | Figure 7 (A and B) The BAL fluids and lungs were harvested 24 h after last rmIL-33 challenge to measure the protein expression of IL-1α, IL-5, IL-13, CCL11, CCL17, CCL22 and CCL24. (C) Cell differentials from BAL fluids harvested 24 h after the last rmIL-33 challenge. The results are shown as mean ± SEM of four mice in... | We assessed cell differentials and cytokine and chemokine expression levels in the BAL fluid and lung homogenates 24 h after rmIL-33 challenge for four consecutive days (Figure 6A). IL-1α protein expression was not changed by exogenous rmIL-33 challenge in lung homogenate (Figure 7A). This result is consistent with a p... | [
"None"
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"None"
] | {
"all_images_paths": [
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} | |||
text_image_inconsistency/numerical/2010147815_TII_01/figure/2010147815_TII_01_3.png | consistency_175 | text_image_inconsistency | [
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] | Figure 4. Binding of a2NTD and intracellular cytokine production in monocyte subpopulations. (A–D) Peripheral blood mononuclear cells (PBMCs) were incubated with 10 μg/mL a2NTD conjugated to Alexa Fluor 488 (a2NTD-AF488) for 1 h and then surface stained with anti-CD14-Pacific Blue and anti-CD16-PE antibodies. (A) Perce... | Uptake of a2NTD by monocyte subsets. To determine if different monocyte subsets preferentially internalize a2NTD, monocytes were stained for the surface markers CD14 and CD16 after incubation with a2NTD. CD14++CD16− cells constitute the majority of all monocytes, while CD14++CD16+ and CD14+CD16++ represent two minor su... | [
"None"
] | [
"None"
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"all_images_paths": [
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} | |||
text_image_inconsistency/trend/2010041524_TII_02/figure/2010041524_TII_02_5.png | consistency_176 | text_image_inconsistency | [
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0
] | Reduced GRHL2 level triggers expression of EDC proteins in differentiating keratinocytes. (a) Rapidly proliferating NHEK were serially subcultured until senescence, and western blotting was performed at varying PD levels for GRHL2, IVL, Jmjd3, and p16INK4A.(b) NHEK were exposed to 1.5mM Caþþfor up to 3 days and collect... | To understand the mechanism by which GRHL2 inhibits EDC gene expression and keratinocyte differentiation, we explored the functional relationship between GRHL2 and epigenetic gene regulation by Jmjd3. In NHEK with increasing PDs, GRHL2 levels progressively decreased while the levels of IVL and p16INK4A decreased (Figur... | [
"None"
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"None"
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"all_images_paths": [
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"figure_ids": [
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} | |||
text_image_inconsistency/trend/2010041695_TII_02/figure/2010041695_TII_02_4.png | consistency_177 | text_image_inconsistency | [
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] | Figure2 Roles of ALK5 receptor and ROS in TGF-b-induced apoptosis in HUVECs. (a) Effects of the ALK5 inhibitor SB431542 (2mM) on TGF-b (10ng/ml for 24h)induced caspase 3/7 activation. (b) Effects of SB431542 on TGF-b-induced caspase 3 cleavage. (c) Effects of SB431542 on TGF-b-induced DCm depression (reduced red fluore... | TGF-b-induced apoptosis is dependent on ALK5 and ROS. To examine whether the ALK5 receptor was involved in TGF-b-induced apoptosis, HUVECs were pre-treated with the ALK5 inhibitor SB431542. Treatment with SB431542 at 2mM enhanced the apoptotic response induced by TGF-b as indicated by caspase 3/7 activation and caspase... | [
"None"
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"None"
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text_image_inconsistency/numerical/2010031950_TII_01/figure/2010031950_TII_01_0.png | consistency_178 | text_image_inconsistency | [
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] | Morphological and growth characterization of hBMCs and hPDCs. (A) Growth curves of hBMCs (human bone marrow derived cells) and hPDCs (human periosteum-derived cells) over 2 weeks in culture. (B) Phase contrast images of hBMCs and hPDCs at one day after seeding at 5 k/cm2, 25 k/cm2, and 85 k/cm2 (scale bar 5 100 mm). Wh... | Independently of the cell culture vessel used, hPDCs proliferated faster than hBMCs and reached full confluence after 7 days (Fig. 1A) when initially seeded at low seeding density (5000 cells/cm2). In addition, the cell density of hPDCs obtained at confluence was consistently higher as compared to hBMCs, which suggeste... | [
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"None"
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text_image_inconsistency/trend/2010168986_TII_02/figure/2010168986_TII_02_2.png | consistency_179 | text_image_inconsistency | [
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] | FIGURE 3. Co-i-cIDPRE evokes Ca2+ increase in human Jurkat cells after UV photolysis. A, Co-i-cIDPRE (200 µM) incited much weaker Ca2+ increases after UV photolysis than that by cIDPRE (200 µM) in Jurkat cells. Fluo-4-loaded cells were incubated in regular HBSS containing extracellular Ca2+ during the experiment. B, af... | It has been shown that cADPR targets the RyR, but which specific isoform it targets remains to be determined (1–3). Here we showed that both RyR2 and RyR3 are expressed in Jurkat cells. Individual knockdown of these isoforms inhibited cIDPRE- or cADPR-induced Ca2+ release to a similar extent, whereas double knockdown o... | [
"None"
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"None"
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} | |||
text_image_inconsistency/trend/2010041443_TII_02/figure/2010041443_TII_02_3.png | consistency_180 | text_image_inconsistency | [
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] | Figure 4 ‘Late’ Hsp27 phosphorylation induced by apigenin is modulated by p38-MAPK and PKCd. Lysates from THP-1 cells treated with 50 μM apigenin for 6 h and diluent or following 1 h pretreatment with 10 μM SB203580, 15 μM rottlerin, or both. Treatments marked with (-) denote addition of diluent. (a) Immunoblots with a... | Next, we investigated the role of p38 and PKCσ on the ‘late’ Hsp27 phosphorylation using pharmacological inhibitors. THP-1 cells were pretreated with the p38 inhibitor SB203580, or the PKCσ inhibitor rottlerin, or both inhibitors, or with diluent for 1 h before the addition of 50 μM apigenin for 6 h. We found that apig... | [
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text_image_inconsistency/numerical/2010065512_TII_01/figure/2010065512_TII_01_2.png | consistency_181 | text_image_inconsistency | [
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] | Figure 3. Expression of histone mRNAs in mouse fibroblast cells and mouse liver. (A) Schematic of generalized S1 nuclease protection assay performed on mouse histone mRNA. A generalized histone mRNA is depicted indicating possible 5’ splice sites (5’ss), stem-loop cleavage sites (S-L cleavage) or poly(A) cleavage sites... | Validation of polyadenylated histone mRNA expression in adult mouse liver. To confirm the expression of the mouse histone mRNAs detected by high-throughput sequencing, we analysed histone gene expression in actively growing cultured fibroblasts (NIH3T3 cells) and liver tissue from 72-week-old mice. The liver is a relat... | [
"None"
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"None"
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} | |||
text_image_inconsistency/numerical/2010011052_TII_01/figure/2010011052_TII_01_0.png | consistency_182 | text_image_inconsistency | [
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] | Production of Th2- and Th1-type cytokines from wild-type and Runt-transgenic CD4⁺ T cells. (A) Naive CD4⁺ T cells were isolated from the spleens of wild-type and Runt–transgenic mice and stimulated with anti-CD3/anti-CD28 antibodies, and the culture supernatants were collected at the indicated times after stimulation. ... | Respectively, compared with the wild-type cells. A similar result as that shown in Figure 1A was obtained when the TCR-stimulated cells were incubated in the presence of IL-2 for 5 d, washed with fresh media, and restimulated via TCR (Figure 1B). Under this neutral culture condition where neither IL-4 nor IL-12 was add... | [
"None"
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"None"
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} | |||
text_image_inconsistency/trend/2010064426_TII_02/figure/2010064426_TII_02_4.png | consistency_183 | text_image_inconsistency | [
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] | Figure 5. Reporter assay tests for the repression of NL4-3 by miR-223 and miR-29. For all transfections, the values represent the average of at least three independent experiments and the error bar represents the standard deviation. (a) Reporter assays show miR-223/29 repression is very weak when Nef serves as the 30 -... | No words | [
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"None"
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} | |||
text_image_inconsistency/trend/2010064989_TII_02/figure/2010064989_TII_02_8.png | consistency_184 | text_image_inconsistency | [
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] | Figure 9. Activity and selectivity of ASOs in the rodent CNS. (A) Allele selective knockdown of muHTT protein with ASO A30 in neuronal cells derived from cortical and striatal tissues of Hu97/18 mouse embryos under free-uptake conditions. (B–D) Hu97/18 mice (n = 4/group) were injected ICV with a single dose of 300 µg o... | Improved allele selectivity in cell culture translates to brains of transgenic mice. We evaluated selected ASOs in Hu97/18 mice (45), a completely humanized mouse model of HD (Figure 9). This mouse model contains both the mutant human HTT allele, with the associated SNPs, and the wt human HTT allele. We first evaluated... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010131195_TII_02/figure/2010131195_TII_02_3.png | consistency_185 | text_image_inconsistency | [
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] | Figure 4. Reversion of Splicing Abnormalities in DM1 Patient-Derived Muscle Cells by CRISPR-SaCas9 Deletion of Expanded CTG Repeats Splicing profiles and quantification of LDB3 exon 11-, ATP2A1 exon 22-, MBNL1 exon 7-, DMD exon 78-, INSR exon 11-, and BIN1 exon 11-containing transcripts in differentiated myoblasts from... | Aggravation of Alternative Splicing Defects in DM1-Edited Muscle Cells Sequestration of MBNL-splicing factors in nuclear foci of DM1 cells leads to alterations in the alternative splicing of numerous pre-mRNAs, some of which are eliminated in differentiated muscle cells in culture.45 We therefore assessed the splicing ... | [
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} | |||
text_image_inconsistency/trend/2010101726_TII_02/figure/2010101726_TII_02_1.png | consistency_186 | text_image_inconsistency | [
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] | Figure 2. Overexpression of Ahi-1 in Sca-1 +lin _x0004_ mouse stem/progenitor BM cells perturbs their in vitro proliferative activity and enhances the effects of BCR-ABL. (A) The levels of Ahi-1 transcripts relative to GAPDH from FACS-purified MIY (Sca-1 + lin _x0004_ YFP +), Ahi-1 (Sca-1 + lin _x0004_ YFP +), BCR-ABL ... | Elevated endogenous Ahi-1 expression was also observed in cells transduced with BCR-ABL alone as compared with control cells (8-fold; P < 0.01; Fig. 2 A). 5 d after transduction, the rate of expansion of the Sca-1 +lin _x0004_YFP + (Ahi-1 +) cells in liquid cultures was approximately twofold lower than in cultures init... | [
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"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010016919_TII_01/figure/2010016919_TII_01_2.png | consistency_187 | text_image_inconsistency | [
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] | ECM softness upregulates MMP secretion and promotes MMP activity. (A) Primary human fibroblasts (2 × 104 cells per well) were seeded onto gels of varying stiffness in 12-well plates and cultured for 48 h. Cell culture medium from each condition was collected and subject to the RayBio Human MMP Array to determine the to... | Matrix metalloproteinases (MMPs) are critical proteinases in ECM degradation and include two major subfamilies of secreted MMPs (MMP-2, -3, etc.) and integral membrane MMPs (MMP-14 [MT1-MMP], -15, etc.; Kessenbrock et al., 2010). For all types of MMPs that were measured, increased ECM stiffness significantly inhibited ... | [
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} | |||
text_image_inconsistency/trend/2010124149_TII_02/figure/2010124149_TII_02_3.png | consistency_188 | text_image_inconsistency | [
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] | Figure 4. Quantitative analysis of CTCF and BORIS expression in human PCa. (A) Nuclear CTCF significantly decreases in metastases cores (P < .001). (B) BORIS nuclear expression significantly increased in cancer cores (P = .002); nuclear and cytoplasmic expression increased in HGPIN cores compared to benign (both P < .0... | CTCF is known to impact gene regulation through the management of chromatin organization and the maintenance of epigenetic marks [26]. CTCF expression levels measured by VECTRA were insignificantly decreased in metastatic PCa tumors (P < .001), but not localized PCa when compared to benign prostate tissues (P = .17) (F... | [
"None"
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"None"
] | {
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"paper_ids": [
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} | |||
text_image_inconsistency/trend/2010011326_TII_02/figure/2010011326_TII_02_2.png | consistency_189 | text_image_inconsistency | [
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"C"
] | [
0
] | Effects of TRAF3 deficiency on effector functions of CD40 and LMP1. (A) A20.2J cells stably transfected with hCD40LMP1 were stimulated with 2 µg/ml anti-mCD40 Ab (CD40), anti-hCD40 Ab to trigger signaling through hCD40LMP1 (LMP1), or isotype control Abs for each (iso1 and iso2) for 48 h. Expression of CD23, CD80, and C... | Effects of TRAF3 Deficiency on Effector Functions. Next, we determined if the effects of TRAF3 deficiency on early signaling pathways of CD40 and LMP1 are predictive of downstream B cell effector functions, including upregulation of surface molecules and secretion of cytokines and antibodies. After CD40 engagement, TRA... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010011326_TII_02/figure/2010011326_TII_02_2.png"
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"tampered": false,
"paper_ids": [
"2010000405"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010104844_TII_02/figure/2010104844_TII_02_3.png | consistency_190 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4 The effects of hydrogels on skin wound healing in type 2 diabetes mellitus (T2D) by topical treatment. (A) Representative images of wounds in the normal control (NC) group, T2D group, CAH (T2D+CAH) group, and CAVBPH (T2D+CAVBPH) group on days 0, 3, 9, and 15. (B) Wound healing rate. *p < 0.05, **p < 0.01, and ... | As shown in Figure 4A, the wound size in all groups decreased gradually over time. Compared with the NC group, the T2D group displayed a slower wound shrinkage due to the influence of diabetes, and exudate was still found on the wound surface on day 9. Topical application of CAH and CAVBPH significantly accelerated dia... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010104844_TII_02/figure/2010104844_TII_02_3.png"
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"tampered": false,
"paper_ids": [
"2010000410"
],
"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010184705_TII_02/figure/2010184705_TII_02_0.png | consistency_191 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. Telomeric element HeT-A expression is downregulated in ovaries by Trf2, Woc and Ars2. (A) RT-qPCR analysis of TE expression in ovaries of Trf2KDnos, wocKDnos and Ars2KDnos. (B) HeT-A transcript abundance in ovaries of Trf2/Trf2, spnE/spnE and Trf2,spnE double mutants. The fold change in the HeT-A RNA level is... | RESULTS Trancription factors Woc and Trf2 suppress telomeric repeat HeT-A transcription in ovaries In order to detect germline components contributing to telomeric homeostasis, we performed a selective RNAi screen for factors that downregulate HeT-A expression in Drosophila ovaries. This approach was based on the exist... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010184705_TII_02/figure/2010184705_TII_02_0.png"
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"tampered": false,
"paper_ids": [
"2010000418"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010011530_TII_02/figure/2010011530_TII_02_4.png | consistency_192 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Agrin-mediated decrease in gap junction–dependent intercellular communication between chromaffin cells in neonates. (A) Reduced number of electrically and LY-coupled chromaffin cells in neonatal agrin-treated slices. *, P ≤ 0.01 when compared with control slices. (B) Monitoring of electrical coupling between chromaffin... | Studies were next undertaken to examine the effect of agrin on both gap junction–mediated electrical and metabolic coupling between neonate chromaffin cells. Metabolic coupling was assessed using Lucifer yellow (LY) to label coupled cells, whereas electrical coupling was evidenced by dual whole-cell patch-clamp recordi... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010011530_TII_02/figure/2010011530_TII_02_4.png"
],
"tampered": false,
"paper_ids": [
"2010000421"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010007150_TII_02/figure/2010007150_TII_02_1.png | consistency_193 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | FIGURE 2. Fold enrichment of selenoprotein mRNAs on UPF1 in low versus high Se.(A) Levels of selenoprotein mRNAs that coprecipitated with UPF1, following culturing HEK293T cells in 3 nM Se or 60 nM Se. Transcript levels are normalized to a synthetic in vitro transcribed RNA and then to the value of the corresponding sa... | We reasoned that if the transcripts that decreased in low Se were undergoing NMD, then they should similarly be enriched on UPF1. The same experiment modeling conditions of low Se was repeated, and RNA immunoprecipitation was performed with UPF1. The cytoplasmic nucleoprotein complexes were coimmunoprecipitated with an... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010007150_TII_02/figure/2010007150_TII_02_1.png"
],
"tampered": false,
"paper_ids": [
"2010000422"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010011652_TII_01/figure/2010011652_TII_01_6.png | consistency_194 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | 3D fibronectin matrix reduces both Rac activity and random migration. (A) Primary human fibroblasts were plated on 2D substrates coated with fibronectin or 3D matrices rich in fibronectin and assayed for activity as in Figure 1. The reduction of active Rac in cells plated in a 3D matrix compared with 2D was 31% (P ≤ 0.... | Cells migrating in 3D cell-derived matrices have different types of cell adhesions, morphology, and signaling when compared with cells in standard 2D tissue culture (Cukierman et al., 2001; Walpita and Hay, 2002). Human fibroblasts in such 3D matrices were found to have a partial, but highly reproducible, 10–50% reduct... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010011652_TII_01/figure/2010011652_TII_01_6.png"
],
"tampered": false,
"paper_ids": [
"2010000578"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010183324_TII_02/figure/2010183324_TII_02_4.png | consistency_195 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Fig. 5. Electrophoretic mobility shift assay results for the AZRE. (A) Sequence-specific interaction of nuclear proteins with the AZRE. The 23 bp AZRE containing a fragment between nucleotides –190 and –168 relative to the transcription start site of Oshsp17.3 was radiolabelled, and 1 ng of the probe was incubated with... | Specificity of nuclear proteins interacting with the 9 bp AZRE in vitro by EMSA. To characterize the putative AZRE further, EMSA was used to determine whether it can interact with trans-acting factor(s) present in nuclear extracts. A 23 bp synthetic oligonucleotide encompassing the AZRE was used as a probe and was labe... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010183324_TII_02/figure/2010183324_TII_02_4.png"
],
"tampered": false,
"paper_ids": [
"2010000586"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010127691_TII_02/figure/2010127691_TII_02_0.png | consistency_196 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. SDHB expression is high in CRC cell lines. (A) Quantitative RT-PCR analysis of SDHB mRNA expression in four colorectal cancer (CRC) cell lines compared to the normal colorectal epithelial cell line NCM460. (B) Semi-quantitative RT-PCR further confirms increased SDHB transcript levels in CRC cell lines relativ... | SDHB is the key enzymatic component of mitochondrial enzyme SDH constructively expressed across species, which oxidizes succinate to fumarate in the TCA cycle and feeds electrons into the mitochondrial respiratory chain for ATP production. We examined SDHB mRNA and protein levels in four CRC cell lines and normal color... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010127691_TII_02/figure/2010127691_TII_02_0.png"
],
"tampered": false,
"paper_ids": [
"2010000588"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010016329_TII_02/figure/2010016329_TII_02_1.png | consistency_197 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Effects of KBrO3 on mtDNA copy number and topology. (A) Dot-blot of purified mtDNA from control cells and cells treated with 30 μM KBrO3. Oxidative damage is detected using an antibody against 8-oxodG by SouthWestern analysis and normalized against total mtDNA by Southern hybridization on a separate blot. (B) Dot-blot ... | Although KBrO3 did not have as dramatic an effect on nuclear DNA damage signaling as UV or H2O2, it induced a marked increase in mtDNA damage (Figure 1A). The damage did not result in copy number depletion or any effect on the supercoiling of mtDNA (Figure 1, C and D). | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010016329_TII_02/figure/2010016329_TII_02_1.png"
],
"tampered": false,
"paper_ids": [
"2010000589"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010064451_TII_01/figure/2010064451_TII_01_0.png | consistency_198 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. Purification of chicken FANCD2, FANCI, FANCL andhuman UBE2T. (A) Purified chicken FANCD2 and FANCI, used forin vitro assays, were analyzed by 15% SDS-PAGE with CoomassieBrilliant Blue staining. Lane 1 indicates the molecular mass markers.Lanes 2 and 3 indicate purified FANCD2 and FANCD2 K563R,respectively. La... | Chicken FANCI and FANCD3 were purified as recombinant proteins (Figure 1A, lanes 3 and 4), and the IDcomplex was prepared by mixing them in 1:1 stoichiometry. We also purified UBE2T and FANCL, which areknown as the E2 and E3 proteins for FANCD2monoubiquitylation, respectively, as recombinantproteins (Figure 1B and C). | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010064451_TII_01/figure/2010064451_TII_01_0.png"
],
"tampered": false,
"paper_ids": [
"2010000598"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} |
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