file_name stringlengths 45 104 | question_id stringlengths 9 23 | fraud_type stringclasses 3
values | fraud_sub_types listlengths 1 3 | ground_truth listlengths 1 3 | mask_indices listlengths 1 9 | mask_caption stringclasses 65
values | mask_path stringlengths 0 106 | figure_caption stringclasses 151
values | figure_related_sentences stringclasses 151
values | inconsistent_part stringclasses 3
values | tampered_sentences listlengths 1 3 | golden_sentences listlengths 1 3 | metadata dict |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
text_image_inconsistency/numerical/2010169000_TII_01/figure/2010169000_TII_01_5.png | consistency_199 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | FIGURE 6. Incorporation of single UV photoproducts increases nucleosome dynamics. A, schematic illustration of the incorporation of a single CPD or 6-4PP into the 601 sequence. The DFs are 12-mer oligonucleotides with the sequences shown. Solid triangles indicate the positions of the photoproduct. The dark circle repre... | Taining a single CPD or 6-4PP lesion is 4.6 nm and 4.2 nm, respectively. Furthermore, in each case, the FRET efficiency is reduced, indicating that the introduction of a single UV lesion in nucleosome DNA can increase NCP unwrapping. This supports the UV dose-dependent FRET change we observed with UV-irradiated NCP DNA... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010095497_TII_02/figure/2010095497_TII_02_0.png | consistency_200 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. Reduced PtdCho synthesis in CCTα-deficient macrophages. (A) Wild-type (WT; n = 12) or CCTα-deficient (KO; n = 12) macrophages were labeled for 6 h with 1 μCi/ml [3H]choline, and incorporation into PtdCho was normalized to cellular protein. (B) Relative transcript levels for CCTα, CCTβ2, CCTβ3, or PEMT were de... | Mice with CCTα-null macrophages were generated as described previously (Zhang et al., 2000). Briefly, mice carrying a floxed Pcyt1a gene were crossed with mice expressing Cre recombinase under the macrophage-specific LysM promoter. Two loxP sites flanked a 12.5-kb fragment of the Pcyt1a gene containing exons 5–9 (Karim... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010065412_TII_02/figure/2010065412_TII_02_1.png | consistency_201 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2. Differential inhibitory effects of SAUGI on the activities of (A) SAUDG, (B) EBVUDG, (C) HSVUDG, (D) human UDG and (E) TBUDG. Except for TBUDG, addition of SAUGI increased the specific uracil-removing activity of SAUDG and the other three UDGs in a dosage-dependent manner. | The inhibiting effects of SAUGI on five UDGs We next used uracil removal assays to investigate the ability of SAUGI to inhibit the same five UDGs that were used in the surface plasmon resonance experiments. In the absence of SAUGI, all the UDGs removed the uracil from the uracil-containing DNA substrates effectively, a... | [
"None"
] | [
"None"
] | {
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"2010000662"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010065375_TII_01/figure/2010065375_TII_01_1.png | consistency_202 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2. HITS-CLIP reveals HIV-1 regions bound by Ago2 in HIV-1 infected cells. (A) HEK293T cells were transfected with plasmid expressing either GFP-Ago2 or control GFP. Twenty-four hours later, they were infected with VSVg-pseudotyped HIV-1 NL4-3 at a M.O.I. of 1 or mock infected. Twenty-four hours later, cells were... | Immunopurified RNAs were radiolabeled, separated on SDS-PAGE and transferred to nitrocellulose membrane. Autoradiograms revealed the presence of RNA–protein complexes migrating from 100 kDa, the expected size of GFP-Ago2, to higher molecular weights corresponding to the size distribution of RNAs associated with GFP-Ago... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010131697_TII_01/figure/2010131697_TII_01_2.png | consistency_203 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. NTCP inhibition by Myrcludex B increases plasma bile acid and GLP-1 levels. (A) Unconjugated, conjugated, and total plasma bile acid levels 3 hours after placebo or Myrcludex B (2.5 mg/g) injection in male obese WT and Oatp1a/1b KO mice (n = 9–10). Mice were fed a HFD for 16 weeks and subsequently treated dai... | To evaluate the in vivo impact of bile acids on GLP-1 secretion, we used the NTCP inhibitor Myrcludex B to prolong bile acid signaling in obese Oatp1a/1b-deficient mice. Treatment with Myrcludex B was started 15 weeks after the onset of obesity by high-fat diet (HFD) feeding. In line with previous research, Oatp1a/1b K... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
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"figure_ids": [
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} | |||
text_image_inconsistency/trend/2010064913_TII_02/figure/2010064913_TII_02_0.png | consistency_204 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. Clk1 enhances SPF45-induced exon 6 exclusion from Fas mRNA. (A) SKOV3 cells were transfected with siRNA against SPF45 (siSPF45) or scrambled control siRNA (scr) for 72 h, and RNA was isolated. Endogenous Fas spliced isoforms were analysed by RT-PCR using primers flanking exon 6. PCR products representing mRNA... | SPF45 enhances exon 6 exclusion from Fas pre-mRNA in a cellular minigene assay (21,33). To determine whether endogenous SPF45 has a dissimilar effect on splicing of endogenous Fas pre-mRNA, we transfected SKOV-3 ovarian cancer cells with siRNA against SPF45. Seventy-two hours after transfection, RNA was harvested, and ... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010064871_TII_02/figure/2010064871_TII_02_1.png | consistency_205 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2. T. brucei Asf1A is nuclear, whereas Asf1B is sporadically cytosolic. Panels (A) and (B) show IFA of procyclic and bloodstream T. brucei, respectively, using specific anti-Asf1A and anti-Asf1B antibodies (antibody), DAPI to stain DNA, merged and DIC images. Panel (C) shows IFA using anti-Myc monoclonal antibod... | To start the characterization of the different histone chaperones, we analyzed their cellular distribution by indirect immunofluorescence analysis (IFA). Surprisingly, IFA showed that the protein previously called Asf1A in T. brucei (25,26) is mainly localized in the cytosol, whereas Asf1B is rarely found in the nucleu... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
"2010000797"
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010190264_TII_02/figure/2010190264_TII_02_2.png | consistency_206 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 3 Mitoprotection preserved calcium cycling activity. Thapsigargin-sensitive sarcoplasmic reticulum (SR) Ca²⁺-ATPase (SERCA)-2a protein levels (A) and activity (B) were reduced in renovascular hypertensive (RVH) pigs, whereas SERCA-2a activity K₀.₅ was decreased (C), but all were improved in RVH+Mitochondrial-tar... | Affinity for calcium was higher than normal (higher SERCA-2a activity K₀.₅), but both were restored in HC-RVH+MTP (Figure 3A through C). PLB activation (p-PLB-S16/total) decreased in HC-RVH+Vehicle, but restored in HC-RVH+MTP (Figure 3D), whereas activation of RYR2 (p-RYR2/Total RYR2) and NCX protein levels were simila... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010131284_TII_01/figure/2010131284_TII_01_5.png | consistency_207 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Fig. 5. Soluble free glycan metabolites in various tissue homogenates and urine from a GLB1 null mouse. Soluble glycans were extracted from a 7-month-old β-galactosidase-deficient mouse and end-labeled with aniline as described in the Methods section. Putative structures are shown over some of the glycan metabolites in... | In order to determine if oligosaccharide metabolites similar to those detected in brain also accumulate in other tissues in the GLB1 null mouse, we screened for soluble glycans in liver, spleen, kidney, and urine samples. We detected the same types of metabolites in all tissues analyzed as well as in urine from the kno... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010041549_TII_02/figure/2010041549_TII_02_0.png | consistency_208 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | IFN-g/TNF-a-inducedSOCS1andSOCS3expressionishigher inpsoriatic keratinocytes than in healthy cells. (a) Cultured keratinocytes were prepared from healthy skin or from biopsies taken from uninvolved psoriatic skin. SOCS1 and SOCS3 mRNA levels were detected by real-time PCR analysis in cultured healthy (Healthy KC, &)(n¼... | To compare SOCS levels in healthy and psoriatic keratinocyte strains, we isolated cells from skin biopsies obtained from psoriatic patients and healthy donors, and left untreated or stimulated with IFN-g plus TNF-a for 3h. We found that SOCS3 and SOCS1mRNA and protein expression was substantially lower in IFN-g/ TNF-a-... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010064722_TII_01/figure/2010064722_TII_01_6.png | consistency_209 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4. RNE associates with RHON1 in a HMW complex. (A) Soluble protein extracts from rhon1TAP or WT were immunoprecipitated using an HA matrix. Samples from stromal extract (L), IP flow through (FT) and the IP eluate (E) were separated in 10% SDS-PAGE and subjected to immunoblot analysis using the antibodies indicat... | To confirm the RNE–RHON1 association by an independent experiment, we investigated Co-IPs of rhon1TAP lines. Using the HA antibody, we could observe a distinct RHON1 signal in lysate, flow through, and eluate of rhon1TAP but not of untagged wild-type lines. Notably, the tagged RHON1 protein shows the same anomaly of mi... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010105083_TII_01/figure/2010105083_TII_01_0.png | consistency_210 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1 (A) Chemical structure of PQDN. (B) Approximately 310 compounds were screened to identify compounds enhancing the activation of CD8 T cells despite weak antigen stimulation. Splenocytes from DUC18 mice were stimulated with 9m antigen in the presence of a compound for 72 hours, and cell proliferation and CD25 e... | RESULTS Identification of a small molecule enhancing CD8 T cell activation even with weak TCR stimulation We screened 310 small molecules from the in-house chemical library of the University of Shizuoka to identify novel compounds that enhance CD8 T cell activation despite weak antigen stimulation. We cultured splenocy... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010115737_TII_02/figure/2010115737_TII_02_0.png | consistency_211 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. Hypoxia promotes cell stemness, migration, and invasion of NSCLC. (a) Sphere formation of CSCs sorted from A549 and H838 cells. (b) The protein levels of the markers of cell stemness including NANOG and CD133. (c) The represent images of cell migration under a microscope. The migration rate was quantified. (d... | To explore the biological functions of hypoxia, we evaluated sphere formation of CSCs and metastasis of NSCLC cells. Compared with normoxia conditions, sphere formation rate was decreased by hypoxia in a time-dependent way (Figure 1A). The protein levels of NANOG and CD133 were upregulated in a time-dependent manner (F... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010113229_TII_02/figure/2010113229_TII_02_4.png | consistency_212 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Fig. 5. Effect of E-64 treatment on development and quality of porcine parthenotes. (A) Blastocyst formation of porcine parthenotes cultured in the presence of E-64. (B) Total cell number was determined using Hoechst 33342 staining. (C) The number of apoptotic cells was determined by TUNEL assay. Black bar, control gro... | Embryos treated with 1 μM (40.3 ± 4.06%) or 10 μM E-64 (39.2 ± 3.33%) displayed increased blastocyst formation compared with the control group (31.6 ± 3.91%). However, formation of blastocysts at a concentration of 100 μM (3.7 ± 3.04%) was higher than that of the control group (P < 0.01, Fig. 5A). Furthermore, we check... | [
"None"
] | [
"None"
] | {
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text_image_inconsistency/trend/2010040265_TII_02/figure/2010040265_TII_02_4.png | consistency_213 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4. DRAM activates autophagy in fibroblasts, driving mitochondrial dysfunction. (A) OXPHOS immunoblotting. Given the upregulation of BNIP3 (a marker of mitophagy), we also investigated the status of mitochondrial OXPHOS (complexes I–V). Note that DRAM-overexpressing fibroblasts showed significant growths in compo... | As BNIP3 is a marker of mitophagy, we also investigated the status of mitochondrial OXPHOS (complexes I–V). Interestingly, DRAM-overexpressing fibroblasts showed significant reductions in components of complex I, III and IV (Fig. 4A) by immunoblotting, consistent with a mitophagy phenotype. Increased L-lactate and keto... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010125211_TII_02/figure/2010125211_TII_02_6.png | consistency_214 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Fig. 4. Inflammatory and immune profile in adult and elderly burned patients. (A–F) Adults show a decrease in inflammatory mediators over time, while elderly demonstrate the opposite picture; IL-6, TNF, IL-15, MCP-1 and GM–CSF all increased over the time course after burn indicating a hypo-inflammation followed by hype... | We hypothesized that elderly have an altered immune and inflammatory response. We first determined a panel of 6 cytokines and chemokines over time. Based on pilot studies we found that elderly have a distinct profile with an early hyper-inflammation followed by a hyper-inflammation after 2 weeks post-burn (data not sho... | [
"None"
] | [
"None"
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} | |||
text_image_inconsistency/numerical/2010035189_TII_01/figure/2010035189_TII_01_4.png | consistency_215 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 2 Cardiometabolic deaths attributable to dietary and metabolic risk factors in the Middle East and North Africa among (A) men, (B) women, (C) total adult population (2010). Other cardiovascular diseases (CVDs) include hypertensive heart disease, aortic aneurysm, rheumatic heart disease, inflammatory heart diseas... | CMD mortality attributable to metabolic risk factors by countryNon-optimal SBP (>115 mm Hg) was the leading metabolic risk for CMD mortality in the region accounting for 48% of CMD deaths (436 190 deaths, 95% UI 422 098 to 651 182) (figure 2). Non-optimal BMI (>23 Kg/m2 ) and fasting plasma glucose (>5.3 mmol/L) caused... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010040066_TII_02/figure/2010040066_TII_02_2.png | consistency_216 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | FIGURE 3 Changes in the activation of epidermal growth factor receptor (EGFR), ERK, and Akt with (+) or without (-) collagen type I (ColI) by gefitinib. A, EGFR, ERK, and Akt phosphorylation (p-) and total protein (t-) in PC-9 cells cultured with or without Col I. B, Quantitative analysis of EGFR, ERK, and Akt phosphor... | Both the MAPK and PI3K pathways are active in primary and acquired resistance to gefitinib. Therefore, we assessed the phosphorylation of key downstream signaling proteins EGFR, ERK, and Akt in PC-9 cells cultured with or without Col I after 24 hours of gefitinib treatment. Gefitinib treatment induced the stimulation o... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010040887_TII_02/figure/2010040887_TII_02_3.png | consistency_217 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4 Levels of inflammatory factors in different groups. (a-e) IgA, IL-4, IL-8, IL-17, TNF-α expression levels of different groups. Notes: Compared with the control group, *P < 0.05, **P < 0.01; Compared with the model group, ##P < 0.01. | PCs Attenuated the Inflammatory Reaction of HSP Serum-Induced CellsHSP serum remarkably enhanced the levels of IgA, IL-4, IL-8, IL-17 and TNF-α of HUVECs (P < 0.05) (Figure 4). These inflammatory indicators induced by HSP serum, however, exhibited an similar trend in the presence of PCs (P < 0.05); that was, PCs promin... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010127706_TII_01/figure/2010127706_TII_01_1.png | consistency_218 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 2. Expression Process of CD36 on Erythroid Cells of Different Origins (A–C) Representative flow cytometry profiles showing expression of CD36 on GPA+ cells derived from hCB-CD34+ HSPCs (A), H1/AGM-S3 co-culture (B), and day-10 + 5 and 10 + 9 suspension cultures (C). | The surface markers of adult HSPC-derived erythroblasts have been well studied (Chen et al., 2009). Our flow cytometry data were consistent with previous reports that as human CD34+ HSPCs differentiate toward erythroblasts, the expression of CD34 disappeared exclusively before gaining expression of erythroid lineage ma... | [
"None"
] | [
"None"
] | {
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010049169_TII_02/figure/2010049169_TII_02_3.png | consistency_219 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 4 Modular analysis of PPI network (A) Module 1 contains 23 genes. (B) Module 3 contains 17 genes. (C) GO and KEGG analysis of genes in Module 1. (D) GO and KEGG analysis of genes in Module 3. | Since the PPI network constructed by us was relatively small, the MCODE plugin was used to calculate the modules with an MCODE score of >5 and identify the most important modules. Finally, a total of 6 modules (for detailed results, see Supplementary Excel S1: Sheet4 and Figure S1) was identified, out of which, two (mo... | [
"None"
] | [
"None"
] | {
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],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010049551_TII_02/figure/2010049551_TII_02_3.png | consistency_220 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4. Validation of microarray data from siWT1 and shWT1 knockdown experiments by Q-RT-PCR. All Q-RT-PCR data are displayed relative to a non-silencing si- or shRNA control that is set at 1. Data represent the mean of triplicates, and the standard deviations are indicated for each experiment. PCR reactions were don... | To gain more insight into the function of mutant WT1Wilms3 and WT1Wilms2 proteins, we performed siRNA (siWT1) knockdown analyses. First, we tested different WT1-specific siRNA oligonucleotides and found that a combination of two siRNAs directed against sequences in exon 6 and the 3′ UTR of WT1 achieved a very efficient... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010049551_TII_02/figure/2010049551_TII_02_3.png"
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"2010001660"
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"figure_ids": [
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} | |||
text_image_inconsistency/trend/2010041482_TII_02/figure/2010041482_TII_02_6.png | consistency_221 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 7 Beclin-1 silencing reduces RGC-5 viability following SD. (a) Effectiveness of Beclin-1 silencing and effect on LC3. Transfection of specific Beclin-1-siRNA or scramble non-targeting (NT) sequence at final concentration of 25 nM was performed, 48 h before SD, in 96-well plate with Lipofectamine 2000 according t... | Beclin-1 silencing reduces RGC-5 viability under starvation. To investigate the effects of Beclin-1 reduction on RGC survival, cells were transfected with rat Beclin-1-siRNA 48 h before SD. Gene silencing reduced Beclin-1 expression by 95% compared with starved scrambletransfected cells as shown by western blotting ana... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041482_TII_02/figure/2010041482_TII_02_6.png"
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"paper_ids": [
"2010001678"
],
"panel_ids": [
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010057590_TII_01/figure/2010057590_TII_01_0.png | consistency_222 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 1. Effects of immediate treatment with eplerenone (Eple) and spironolactone (Spiro) on survival and hemodynamics in mice 3 days after myocardial infarction (MI). (A) Kaplan-Meier survival curve analyzed by log-rank test (*P < 0.05). (B) Hemodynamic measurements including left ventricular filling pressure (LVEDP)... | Kaplan-Meier analysis demonstrated significantly improved survival at 7 days post-infarction exclusively in eplerenone-treated mice (Figure 1A). Infarct sizes were comparable across all experimental groups (Table 1). At 7 days post-MI, placebo-treated mice developed: (1) elevated left ventricular filling pressure (LVED... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010057590_TII_01/figure/2010057590_TII_01_0.png"
],
"tampered": false,
"paper_ids": [
"2010001695"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010129304_TII_02/figure/2010129304_TII_02_2.png | consistency_223 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Fig. 1. DLA-M decreases body weight and improves insulin resistance in HFD C57BL/6J mice. NCD and HFD (60% kcal fat) C57BL/6J mice were treated daily with water or 1 g/kg/day DLA-M by intragastric gavage for 10 weeks (n = 6–15). Effects of DLA-M treatment on the body weight gain and the calculated AUC (a), serum TG and... | Two mouse models of obesity—10-week-old male C57BL/6J and CD-1 mice—were fed a normal chow diet (NCD) or a high-fat diet (HFD) for 10 and 5 weeks, respectively. In agreement with previous work using an obese rat model (Xu et al., 2016), DLA-M prevented body weight loss in both animal models, but did not cause a signifi... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010129304_TII_02/figure/2010129304_TII_02_2.png"
],
"tampered": false,
"paper_ids": [
"2010001701"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010014696_TII_02/figure/2010014696_TII_02_2.png | consistency_224 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Calcineurin removes activating phosphorylations from Hcm1. (A) Strains expressing the indicated Hcm1 proteins were treated with CaCl2 for 10 min, and phosphorylation was assayed by Phos-tag Western blot. Note that the top band in the 12C sample is also present in the 15A sample, suggesting that it is the result of Cdk1... | Under these gel conditions, the phosphorylation status of a panel of Hcm1 mutants with different numbers of Cdk1 phosphosites is clearly distinguishable (Figure 2, A and C). In addition, we found that within 10 min of direct CN activation by the addition of CaCl2 to the growth medium, Hcm1 was mildly dephosphorylated (... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010014696_TII_02/figure/2010014696_TII_02_2.png"
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"paper_ids": [
"2010001712"
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"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010073211_TII_01/figure/2010073211_TII_01_3.png | consistency_225 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4. Effect of pH on the release of methylprednisolone (MP) from the BSA633-MP nanoconjugate. The nanoconjugates were incubated in (A) PBS at pH 7.4 and (B) acetate buffer at pH 4.0 for 48 h at 37°C. After incubation, samples were eluted in a column with Sephadex G-100 gel. An amount of 0.5 ml of each fraction was... | Release profile of BSA633‑MP. The effects of neutral pH and relatively acidic pH on the release profile of BSA633‑MP conjugate were evaluated. As shown in Fig. 4A, we clearly see that under pH 7.4, almost nothing was released from the BSA633-MP conjugate. However, under pH 4.0, most MP molecules were released, a small ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010073211_TII_01/figure/2010073211_TII_01_3.png"
],
"tampered": false,
"paper_ids": [
"2010001836"
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"panel_ids": [
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010035913_TII_02/figure/2010035913_TII_02_3.png | consistency_226 | text_image_inconsistency | [
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"C"
] | [
0
] | Figure 3 Percentage of patients achieving glycaemic control according to HbA1c intervals. HbA1c, glycated haemoglobin; T2DM, type 2 diabetes mellitus | Finally, the analysis of the evolution of the attained glycaemic control according to different HbA1c intervals also showed that there were many remarkable changes among years in any case (figure 3). Of note, the group of patients who were less likely to achieve the corresponding glycaemic target included those younger... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010035913_TII_02/figure/2010035913_TII_02_3.png"
],
"tampered": false,
"paper_ids": [
"2010001838"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010123552_TII_01/figure/2010123552_TII_01_0.png | consistency_227 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Fig. 1. Hepatic insulin receptor substrate and PI3K proteins expression in ApoE knock-in mice. (A) Western blot analysis of insulin receptor substrate-1 (IRS1), PI3K/p85 and PI3K/p110 levels in the liver of ApoE3 and ApoE4 mice at 12 and 72 weeks of age. β-actin was immunoblotted to ensure similar gel loading of the st... | At 72 weeks, insulin receptor substrate 1 (IRS1) expression does not differ between fasting ApoE3 and ApoE4 mice (Fig. 1A). At 12 weeks, however, IRS1 expression is non-detectable in the fasting ApoE4 KI mice. We then examined the expression of the catalytic subunit (p110) and the regulatory subunit (p85) of phosphatid... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010123552_TII_01/figure/2010123552_TII_01_0.png"
],
"tampered": false,
"paper_ids": [
"2010001866"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010127336_TII_02/figure/2010127336_TII_02_0.png | consistency_228 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 1: MRTFA KO mice have smaller body weight, reduced bone mass with shorter femurs and tibiae. WT (n = 7) and MRTFA KO (n = 7) female mice (24 weeks old) were euthanized and then weighed. The image of a matched pair of WT and MRTFA KO mice is shown in (A). The femurs and tibiae of the mice were then dissected (ima... | Six-week-old MRTFA KO mice are taller and weigh less than WT littermates (Figure 1A and B and Supplementary Figure 1). This observation suggested that there might be a defect in skeletal development. To investigate a possible role of MRTFA in bone formation, lengths of the femurs and tibiae were measured with calipers.... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010127336_TII_02/figure/2010127336_TII_02_0.png"
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"tampered": false,
"paper_ids": [
"2010001884"
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"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010014663_TII_02/figure/2010014663_TII_02_3.png | consistency_229 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | The c-Myb protein level is critical for GSK3β-dependent cell survival. (A) Jurkat, K562, and RPMI 8226 cells were treated with or without 5 or 10 μM SB216763 for 8 h, and cell lysates were analyzed by immunoblotting. (B) RPMI 8226, K562, and Jurkat cells were infected with lentivirus expressing GSK3β shRNA or a nonspec... | We next tested the effect of GSK3β inactivation on the c-Myb and LEF-1 proteins. Of importance, in all leukemia cells examined, the levels of c-Myb were increased upon SB216763 or LiCl treatment, whereas the levels of LEF-1 did not show significant similarity (Figure 4A and Supplemental Figure S3). RNAi-mediated deplet... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010014663_TII_02/figure/2010014663_TII_02_3.png"
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"tampered": false,
"paper_ids": [
"2010001886"
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"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010124577_TII_01/figure/2010124577_TII_01_0.png | consistency_230 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 1. hMSC-to-MF Activation Reduces Clonogenicity and Lineage Differentiation Potential (A and B) hMSCs were cultured with and without TGF-β1 (2 ng/ml) for 4 days to assess MF activation by staining for α-SMA (red) and stress fibers (F-actin, green), for 10 days to assess CFU-F formation, and 14 days to assess adip... | MF Activation Results in Reduced Clonogenicity and Differentiation Potential of hMSCsIndependently of MSC origin, MF activation occurs spontaneously in standard cell culture on rigid tissue culture plastic in serum-containing media. Cultured hMSCs derived from adipose tissue, umbilical cord perivasculature, and bone ma... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010124577_TII_01/figure/2010124577_TII_01_0.png"
],
"tampered": false,
"paper_ids": [
"2010001903"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010127644_TII_02/figure/2010127644_TII_02_4.png | consistency_231 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 3. Silica-coated ZnO NPs exhibit antimicrobial activity comparable to uncoated ZnO NPs. The growth of *E. coli* was inhibited by both uncoated and silica-coated ZnO NPs after (A) 3 h and (B) 21 h of incubation. Similarly, the growth of *S. aureus* was significantly inhibited by both types of NPs after (C) 3 h an... | After confirming the presence of silica coating on ZnO nanoparticles (NPs), we assessed how this modification affects their antimicrobial properties. As shown in Figure 3, the silica coating retained—and in the case of *S. aureus*, even slightly enhanced—the antimicrobial effect upon both short (3 h) and long (21 h) ex... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010127644_TII_02/figure/2010127644_TII_02_4.png"
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"tampered": false,
"paper_ids": [
"2010001978"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010013696_TII_01/figure/2010013696_TII_01_8.png | consistency_232 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | SNV binding to integrin PSI domain recapitulates physiological activation of αIIbβ3. (A, B) Model of SNV-induced extended conformation associated with a high-affinity state with separated α and β transmembrane and cytoplasmic domains, which allows the ligand-mimetic monoclonal anti-αIIbβ3 antibody PAC1 to bind to CHO-A... | In the C3 cells, the αIIb 968 tryptophan (W) and the 693 isoleucine (I) residues were replaced with cysteines to prevent the separation of the cytoplasmic domains through constitutive disulfide bond formation (Luo et al., 2004) (Figure 9). Exposure of CHO-A24 and CHO-C3 cells to SNV for 5 min produced a twofold increas... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010013696_TII_01/figure/2010013696_TII_01_8.png"
],
"tampered": false,
"paper_ids": [
"2010002000"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010074157_TII_02/figure/2010074157_TII_02_3.png | consistency_233 | text_image_inconsistency | [
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"C"
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0
] | Figure 4. DLS inhibits chemokine-mediated signaling in CCR5-transfected 3T3 cell lines. Approximately 200,000 3T3.T4.CCR5 cells were grown overnight per well in a 6-well plate. On the following day, the media was replaced with 2 ml of serum-free medium. After 2–3 h, DLS (20 μM) or the CCR5-specific antagonist, TAK779 (... | 3T3.T4.CCR5 cells were grown overnight and then pretreated with DLS (20 μM) or the CCR5-specific antagonist, TAK779 (2 μM) for 30 minutes at 37 °C, after which 10 nM of MIP-1β or RANTES were added to cultures. The cells were harvested in RIPA after washing with cold PBS at the indicated times. The results (Figure 4) re... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010074157_TII_02/figure/2010074157_TII_02_3.png"
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"tampered": false,
"paper_ids": [
"2010002043"
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"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010040108_TII_02/figure/2010040108_TII_02_0.png | consistency_234 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | FIGURE 1 Dickkopf-1 (DKK1) inhibition reverses suppressive tumor immune microenvironment of a syngeneic gastric cancer (GC) model. (A) Schematic of DKK1 inhibitor (WAY-262611) treatment schedule in GC subcutaneous model. (B) Representative images of tumors and (C) tumor volumes of mouse forestomach carcinoma (MFC)-chal... | To investigate whether DKK1 inhibition showed antitumor efficacy in GC models, we established an MFC-challenged GC syngeneic immunocompetent mouse model and a T cell-deficient mouse model, followed by treatment with DKK1 inhibitor (WAY-262611) or DMSO (control group for WAY-262611) as indicated (Figures 1A and S1A). An... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010040108_TII_02/figure/2010040108_TII_02_0.png"
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"paper_ids": [
"2010002073"
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"panel_ids": [
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010049515_TII_02/figure/2010049515_TII_02_2.png | consistency_235 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 3. p53 expression at both the protein and mRNA level. (A) Western blot of p53 protein in SDHx variant-positive CS/CSL (patient ID—SDHx variant: 829LL-S163P, 1965ML-S163P, 2094GR-H50R, 2549MP-G12S, 2854PS-S163P, 2894KP-H50R) and normal control groups. Upper panel shows the protein profile under normal culture con... | Exposure of cells to high levels of ROS leads to oxidative stress, and should induce a p53-mediated response including apoptosis, whereas we observed the opposite in our cases. Therefore, we decided to investigate if p53 is somehow modified in our patient samples in order to escape the expected apoptotic regulation. We... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010049515_TII_02/figure/2010049515_TII_02_2.png"
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"paper_ids": [
"2010002143"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010074872_TII_02/figure/2010074872_TII_02_8.png | consistency_236 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 9. Alizarin-red assay to bone matrix mineralization. (A) Staining (Scale bar: 100 μm), and (B) Quantitative calcium level deposition. Data are expressed as the mean ± S.D (n = 3). *p < 0.05, **p < 0.001. | Extracellular matrix mineralization and quantitative calcium-level deposition were determined at 14 days postculture by Alizarin red staining. As shown in Figure 9A, in the presence of His‑βCD‑PH and HP‑βCD‑PH, matrix mineralization was decreased clearly compared with the control. Free PH in DMSO at a concentration of ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010074872_TII_02/figure/2010074872_TII_02_8.png"
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"tampered": false,
"paper_ids": [
"2010002283"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010119081_TII_02/figure/2010119081_TII_02_2.png | consistency_237 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Fig. 3. Effects of curcumin on serum TGF-β1 and lung TGF-β1 and CTGF expression in irradiated rats. (A) Serum concentrations (n = 5–6 per group) of TGF-β1 in control (CTL), radiation (RT), radiation＋curcumin (RT＋Cur), and curcumin (Cur) rats. (B) Western blot showing TGF-β1 and CTGF in lung from each group. (C) Quantif... | To evaluate whether curcumin could attenuate radiation-induced collagen synthesis in rat lungs, we assessed serum TGF-β1 levels by ELISA and TGF-β1 and CTGF expression levels with western blots (Fig. 3). Serum TGF-β1 levels from irradiated rat lungs were significantly decreased compared to irradiated curcumin-treated r... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010119081_TII_02/figure/2010119081_TII_02_2.png"
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"paper_ids": [
"2010002308"
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"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010079947_TII_01/figure/2010079947_TII_01_0.png | consistency_238 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 1. Effects of NFKBIE knockdown on the expression levels of SLC19A1 and ABC transporters. Quantitative gene expressions of NFKBIE (A), SLC19A1 (B), ABCC1 (C), ABCC5 (D), and ABCG2 (E) genes in control (gray) and NFKBIE knockdown (black) MH7A treated with or without 0.01, 0.1, 1, 5, and 10 mM methotrexate (MTX) ap... | To investigate the effects of NFKBIE knockdown on the expressions of drug membrane transporters, we confirmed expression by qRT-PCR. The NFKBIE expression level in the NFKBIE knockdown group was almost 18–20% of the control expression level under many conditions (Figure 1A). NFKBIE knockdown could reduce the SLC19A1 ex... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010079947_TII_01/figure/2010079947_TII_01_0.png"
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"tampered": false,
"paper_ids": [
"2010002328"
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"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010057714_TII_02/figure/2010057714_TII_02_3.png | consistency_239 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Figure 4. Direct vascular effects of particles in rat aortic rings in vitro. Effect of diesel exhaust particles (filled circle), carbon nanoparticles (u) (both 100 μg/mL), or vehicle (open circle) (Krebs buffer) on (A) phenylephrine contraction in mN, (B) phenylephrine contraction as a percentage of maximum contraction... | In vitro exposure of rat aortic rings to diesel exhaust particles produced a small decrease in the maximum contractile response to phenylephrine (P=0.03, unpaired t-test; Figure 4A), without affecting the sensitivity to phenylephrine. Pure carbon nanoparticles did not significantly alter responses to phenylephrine and,... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010057714_TII_02/figure/2010057714_TII_02_3.png"
],
"tampered": false,
"paper_ids": [
"2010002366"
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"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010013350_TII_01/figure/2010013350_TII_01_2.png | consistency_240 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Defect of fertilization in Pmis2−/− mice and transgenic rescue. (A) Pmis2+/− males and Pmis2−/− females delivered normal numbers of pups when mated with WT mice, whereas the combination of WT females with Pmis2−/− males produced no pups. (B) The defect was at the fertilization level, because no fertilized eggs were rec... | Pups were obtained from Pmis2+/− males and Pmis2−/− females, whereas Pmis2−/− male mice sired no pups in spite of their normal mating behavior (Figure 3A). Eggs were collected from the oviducts after examining for the formation of a vaginal plug, and the fertilization rate was examined. We could obtain no fertilized eg... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010013350_TII_01/figure/2010013350_TII_01_2.png"
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"tampered": false,
"paper_ids": [
"2010002370"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010027154_TII_01/figure/2010027154_TII_01_2.png | consistency_241 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 3. a) Schematic representation of different functionalization approaches of SWCNTs with 2_2 and results after three hot filtration steps. b) TGA trace of the reaction outcome (rt to 1000°C, 10°Cmin^-1 under air) for the degree of functionalization (black: pristine SWCNTs, blue: Rev-MINT, red: Irrev-MINT and gree... | Having macrocycles 1_2 and 2_2 as well as efficient conditions for disulfide exchange in hand, we tested our key hypothesis that SWCNTs could act as convex templates during the reversible covalent opening and closing of the concave rings (Figure 3 a, top). The collected solids werewashed multiple times by suspending in... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"paper_ids": [
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"figure_ids": [
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} | |||
text_image_inconsistency/trend/2010011621_TII_02/figure/2010011621_TII_02_3.png | consistency_242 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Increased TCR–CD3 recycling is revealed in hypertonic medium. (A) Uptake of Alexa647-labeled transferrin by Jurkat T cell lines expressing SLAP-GFP or control (GFP) in the presence or absence of hypertonic medium, as assessed by FACS. (B) Expression of CD3ε on Jurkat T cell lines expressing SLAP-GFP or control (GFP) in... | To validate the use of hypertonic medium to inhibit TCR–CD3 internalization, we first analyzed the uptake of fluorescently labeled transferrin by the transferrin receptor, a process that requires clathrin-mediated endocytosis (Mellman, 1996; Schmid, 1997). Because DP thymocytes do not express the transferrin receptor, ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010011621_TII_02/figure/2010011621_TII_02_3.png"
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"paper_ids": [
"2010002377"
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],
"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010018540_TII_01/figure/2010018540_TII_01_3.png | consistency_243 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Fluorogram of HDL apoproteins isolated from rough- and smooth-endoplasmic reticulum fractions. Young chickens were administered t-[aH]leucine and, after 10 min, the livers were removed, fractionated into RER and SER fractions, and the HDL contained within these fractions was isolated by centrifugal flotation and immuno... | There was a small amount of radioactivity in the high molecular weight range, which could be due to aggregation of protein, but there was no evidence of the presence of radioactive proteins of lower molecular size than apoprotein AI (Fig. 4, lanes 3 and 4). By contrast, the contents of the RER and the SER cell fraction... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010018540_TII_01/figure/2010018540_TII_01_3.png"
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"paper_ids": [
"2010002382"
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010019350_TII_02/figure/2010019350_TII_02_5.png | consistency_244 | text_image_inconsistency | [
"None"
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"C"
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0
] | Cell culture experiments analysing the effects of reggie-1 on Wg and Hh secretion. (A) Effects of overexpression of reggie-1 on Wg secretion measured by Western blots. Serum albumin is shown as the loading control for the medium samples. (B) Effects of overexpression of reggie-1 or a reggie dominant-negative construct ... | We found a dramatically lower uptake of Wg by DsRed cells when Wg was provided by the reggie-1-overexpressing cells (Figure 5D and E). To prove that this intracellular Wg staining resulted from endocytosis, we performed pulse–chase assays with fluorescent dextran beads and found that Wg provided by reggie-1-expressing ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010019350_TII_02/figure/2010019350_TII_02_5.png"
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"paper_ids": [
"2010002384"
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"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010028694_TII_02/figure/2010028694_TII_02_8.png | consistency_245 | text_image_inconsistency | [
"None"
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"C"
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0
] | (A) In vivo antitumor activity of PSSN10 and various DOX formulations in a syngeneic murine breast cancer model (4T1.2). Three injections were administered on d 0, 3 and 6. **P<0.01. (B) Kaplan-Meier survival of 4T1.2 tumor-bearing mice after various treatments. (C) Histological analyses of H&E stained sections of ... | Figure 5A shows the in vivo therapeutic effects of PSSN10 and DOX/PSSN10 with free DOX and DOXIL (a clinical formulation of liposomal DOX) as controls (5 mg DOX/kg). The PSSN10 carrier alone showed a significant effect in inhibiting tumor growth, comparable to those of DOX and DOXIL. This is in contrast to the in vit... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010028694_TII_02/figure/2010028694_TII_02_8.png"
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"tampered": false,
"paper_ids": [
"2010002385"
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"figure_ids": [
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],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010041575_TII_02/figure/2010041575_TII_02_3.png | consistency_246 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Cannabinoids induce AMPK-dependent GAPDH nuclear translocation. Representative confocal images of GAPDH translocation in Panc1 cell nuclei after 12h treatment with 200mM GW or ACPA in the absence or presence of a pretreatment for 1h with 20mM NAC or 20mM C.C. Values are the means of three independent experiments (±S.D.... | we analysed the cellular distribution of GAPDH after the treatment with GW or ACPA. Figure 4 shows the confocal images where GAPDH appear to be translocated into the nucleus of the cells after 12-h cannabinoid treatments. This effect was stimulated by NAC or CC, indicating its dependence on ROS and AMPK activation. The... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041575_TII_02/figure/2010041575_TII_02_3.png"
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"tampered": false,
"paper_ids": [
"2010002386"
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"panel_ids": [
"None"
],
"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010041585_TII_02/figure/2010041585_TII_02_5.png | consistency_247 | text_image_inconsistency | [
"None"
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"C"
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0
] | CPEB1 reduces senescence by regulating p53 distribution in glioma cells. (a) A cell growth assay was used to analyze the function of CPEB1 siRNA in glioma cell proliferation. *Po0.05. (b) The effect of CPEB1 siRNA on senescence in glioma cell lines as determined with SA-b-gal staining. Arrows indicate the green senesce... | The knockdown of CPEB1 reduced senescence by regulating p53 distribution in glioma cells. Burns DM et al.18 demonstrated that CPEB1 was repressed by miR-122, and the inhibition of CPEB1 activated p53 translation in human skin fibroblasts. p53 is one of the hallmarks of cellular senescence;19 therefore, the p53-mutated ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041585_TII_02/figure/2010041585_TII_02_5.png"
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"tampered": false,
"paper_ids": [
"2010002387"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010041660_TII_02/figure/2010041660_TII_02_3.png | consistency_248 | text_image_inconsistency | [
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"C"
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0
] | Figure4 Inhibition of ADAM17 modulates phosphorylation of p44 MAPK. (a) Levels of p44 MAPK phosphorylation were decreased after ADAM17 inhibition with medium and high concentrations of BMS-561392, whereas p42 MAPK phosphorylation was not affected in immature HOG oligodendrocytes. (b) Microglial BV-2 cells were treated ... | On the contrary, levels of p44 MAPK phosphorylation were significantly increased with the highest concentration of BMS-561392 (2.7mM) in oligodendrocytes (Figure 4a), whereas in microglial cells phosphorylation of p44 MAPK was significantly decreased by the lower concentration of BMS-561392 (0.3mM) and significantly di... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010041660_TII_02/figure/2010041660_TII_02_3.png"
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"paper_ids": [
"2010002388"
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010131029_TII_01/figure/2010131029_TII_01_0.png | consistency_249 | text_image_inconsistency | [
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"C"
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0
] | Fig. 1. Protective effects of PTZ against ROT-induced toxicity on primary ventral midbrain cultures. (A) Representative scans from immunocytochemical preparations acquired with a 20× objective lens. PTZ protects TH+ (A11) and MAP2 neurons (A12) against the deleterious effects of ROT with ensuing increase in the percent... | Administration of 50 nM ROT to 5-day-old primary rat DA cell cultures over a period of 5 days leads to neuron degeneration. We therefore sought to investigate the potential neuroprotective properties of PTZ (Fig. 1). We first examined whether unsubstituted PTZ improves cell survival (Fig. 1 A). PTZ alone did not show e... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010131029_TII_01/figure/2010131029_TII_01_0.png"
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"tampered": false,
"paper_ids": [
"2010002389"
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"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010000184_TII_01/figure/2010000184_TII_01_9.png | consistency_250 | text_image_inconsistency | [
"None"
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0
] | Figure 6.Vault RNA expression varies in actino-mycin D–treated MEFs. Northern analysis of RNA prepared from wild-type (MEF11) and mTep1-deficient (MEF8 and MEF5) cells treated with actinomycin D for the indicated times. The membrane was probed with mTR (top), stripped,and reprobed first with mVR (middle) and next with ... | In wild-type MEF cells, vRNA has a half-life of 5–6 h; however, in both mTep1 MEF lines, the vRNAs half-life is reduced to 0.3–1 h (Fig. 6, mVR). The blots were stripped and reprobed with either mTR or 5S (a loading control).No effect is seen on the stability of the mTR (Fig. 6). | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002395"
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010005088_TII_01/figure/2010005088_TII_01_2.png | consistency_251 | text_image_inconsistency | [
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0
] | Fig. 5 Lethality of antiprogestins towards ovarian cancer cells. OV2008 or SK-OV-3 cells were cultured in the presence of 40 μM RU-38486, ORG-31710 or CDB-2914. After 60 h (OV2008) or 120 h (SK-OV-3), floating cells were collected, adhered to a microscope slide, stained with DAPI, and microscopic phase contrast and flu... | The majority of the cells at this point in time appear detached and with morphological features similar to those shown by cisplatin-treated cells (Fig. 5a). SK-OV-3, although less sensitive to the lethal effects of the antiprogestins, show a remarkably reduced number of still adherent cells after 96 h treatment with a ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010005088_TII_01/figure/2010005088_TII_01_2.png"
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"paper_ids": [
"2010002398"
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"panel_ids": [
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010065349_TII_02/figure/2010065349_TII_02_0.png | consistency_252 | text_image_inconsistency | [
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] | Figure 1. MLH1 deficiency has little effect on telomere maintenance. (A) Immunoblotting shows the absence of MLH1 in HCT116 and the restore of MLH1 expression in HCT116MLH1. (B) Telomere length measured by TRF analysis in HCT116 and HCT116MLH1. (C) Immunoblotting shows MLH1 knockdown in HeLa cells. Two shRNA sequences ... | To determine whether MLH1 deficiency impacted telomere maintenance, we first examined telomere length with the TRF assay using two cell lines from different origins: first, the MLH1-deficient human colorectal tumor cell line HCT116 and its isogenic cell line complemented with wild-type MLH1, HCT116MLH1 (39) and second,... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002403"
],
"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010065654_TII_01/figure/2010065654_TII_01_1.png | consistency_253 | text_image_inconsistency | [
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0
] | Figure 2. A full-length human ORF1p suppresses retrotransposition of chimeric L1s containing human ORF1 sequence. (A) Schematic of neomycin-tagged, full-length chimeric L1s containing human and/or mouse codon-optimized ORF1 and ORF2 sequences. Human ORF1 and human ORF2 are designated as H1 and H2, mouse ORF1 and mouse ... | To assess which of the L1-encoded proteins may be involved in the response to ORF1p trans effect on L1 retrotransposition, we used previously reported chimeric L1 constructs containing codon-optimized ORF1 and ORF2 sequences of either human or mouse origin (Figure 2A) (28). Specifically, we used the H1H2 and M1M2 L1s, ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010065654_TII_01/figure/2010065654_TII_01_1.png"
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"paper_ids": [
"2010002414"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010065702_TII_02/figure/2010065702_TII_02_2.png | consistency_254 | text_image_inconsistency | [
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0
] | Figure 2. Hypoxia induces release of miR-574-3p from Ago2 suppressing RISC-mediated activity. (A) Hypoxia switches binding of miR-574-3p from Ago2 to hnRNP L. U937 cells were cultured in hypoxia for 24 h. Lysates with the same quantity of total protein were subjected to IP with anti-hnRNP L, -Ago2 or pre-immune IgG ant... | To begin to explore the influence of hnRNP L binding to miR-574-3p on its RISC-driven tumor-suppressive activity, we showed that hypoxia induces expression of EP300, an established downstream target of miR-574-3p (Figure 2B) . EP300 is a transcriptional co-activator of NF-κB, a key transcription factor regulating infla... | [
"None"
] | [
"None"
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"all_images_paths": [
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"paper_ids": [
"2010002416"
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"panel_ids": [
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010009856_TII_01/figure/2010009856_TII_01_0.png | consistency_255 | text_image_inconsistency | [
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0
] | Characterization of the properties of APPYFP transport in Drosophila segmental nerve axons in vivo. (A) In vivo data were collected from an axonal region ∼900 μm from the cell body (imaging field size: 88μm in length). A standard data set consisted of four video segments of 15-s duration recorded for 10 individual anim... | We probed the transport behavior of individual APP vesicles in vivo by using SG26.1 Gal4 (Gal4 gene enhancer trap strain) to drive the expression of UAS-APPYFP in Drosophila. Because the expression of SG26.1 Gal4 is confined to a subset of ventral ganglion neurons, APPYFP movement could be tracked with single-axon reso... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"paper_ids": [
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"panel_ids": [
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010009958_TII_01/figure/2010009958_TII_01_5.png | consistency_256 | text_image_inconsistency | [
"None"
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"C"
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0
] | Transfer of [14C] cholesterol and loss of acceptor liposomes (loss of fluorescence) mediated by NPC2 and fusogenic Sap C. (A) Cholesterol transfer depending on the concentration of bNPC2 in the presence or absence of 20 mol% BMP. (B) bNPC2-mediated fluorescence loss, which implies membrane fusion. As a control we inves... | Sap C is required for the lysosomal degradation of membrane-bound glucosylceramide (53). Its fusogenic property had been established by measuring its ability to destabilize lipid vesicles (66–69). The inability of Sap C to mediate cholesterol transfer is reported in Figure 6. Figure 6A clearly shows that bNPC2 mediates... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010009958_TII_01/figure/2010009958_TII_01_5.png"
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"paper_ids": [
"2010002418"
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"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010006583_TII_02/figure/2010006583_TII_02_2.png | consistency_257 | text_image_inconsistency | [
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0
] | Fig. 3 Mitochondrial DNA (mtDNA) damage in M. mulatta aorta. MtDNA damage was quantified from genomic DNA preparations extracted from aorta. a mtDNA damage determined by QPCR; (n = 3/group/tissue). The inset (lanes 1–3 are unexposed control, lanes 4–6 are ETS exposed) shows the full-length QPCR product (Long) that is u... | To determine whether perinatal ETS exposure impacted mitochondrial integrity, quantitative PCR was performed on aortic tissue collected from M. mulatta. Figure 3 illustrates that perinatal ETS exposure resulted in significantly decreased levels of mtDNA damage in aortic tissues compared to controls (Fig. 3a; less produ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002420"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010169875_TII_02/figure/2010169875_TII_02_1.png | consistency_258 | text_image_inconsistency | [
"None"
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"C"
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0
] | Figure 2. NF-κB activation by hypertonicity in part depends on p38 kinase activity. (A) Protein lysates from cells challenged or not (Ctl) with either LPS, TNF-α, or hypertonic medium (NaCl) were analyzed by immunoblot for phosphorylated forms of p38 kinase, p38 substrate ATF2, ERK, JNK, and JNK substrate c-Jun. PKAc w... | Influence of each of these MAPKs on hypertonicity-inducible NF-κB activation, we measured the effects of pharmacological inhibition of p38 kinase, ERK, and JNK. A comparison of ATF2 (used as an indicator for p38 kinase activity), ERK, and c-Jun (used as an indicator for JNK activity) phosphorylation revealed that each ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"tampered": false,
"paper_ids": [
"2010002507"
],
"panel_ids": [
"None"
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"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010184669_TII_02/figure/2010184669_TII_02_0.png | consistency_259 | text_image_inconsistency | [
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] | Figure 1. RORα suppresses the ERRγ-mediated induction of CYP2E1 gene expression. (A) Primary cultures of mouse hepatocytes were treated with 20 μM ACEA in the presence or absence of 20 μM CS, 5 μM SR1078 or 20 μM JC1–40 for 24 h. Or the hepatocytes were infected by Ad-GFP or Ad-ERRγ and then underwent the same treatmen... | RESULTS RORα represses the ERRγ-mediated induction of CYP2E1 expression CYP2E1 is a key enzyme causing alcohol-induced oxidative stress and liver injury. To illustrate the pathophysiological role of RORα in ALDs, we examined whether RORα affected expression level of CYP2E1 under ethanol exposure. Since alcohol-induced ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010184669_TII_02/figure/2010184669_TII_02_0.png"
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"paper_ids": [
"2010002592"
],
"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010130956_TII_01/figure/2010130956_TII_01_0.png | consistency_260 | text_image_inconsistency | [
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0
] | Fig. 1. Long linear DNA fails to transfer by acoustic dispensing. PicoGreen® dsDNA dye was used to measure the fluorescent signal from long, linear lambda DNA (A) or supercoiled plasmid DNA (B) at a range of concentrations after 1 μl sample was transferred either by manual pipetting or acoustically using the Echo®, in ... | We tested a selection of plasmid DNA samples in the miniaturised dsDNA quantification assay, with samples transferred either manually or by acoustic dispensing (Fig. 1C and D). The samples were also run on an agarose gel (Fig. 1E). When the concentration of the samples was interpolated from the standard curve in the as... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010130956_TII_01/figure/2010130956_TII_01_0.png"
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"tampered": false,
"paper_ids": [
"2010002650"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010184389_TII_01/figure/2010184389_TII_01_0.png | consistency_261 | text_image_inconsistency | [
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0
] | Figure 1. Massive, RDR-independent generation of CaMV vsRNAs in infected Arabidopsis. (A) Total RNA from pools of CaMV-infected (+) or mock-inoculated (−) wild-type control plants (Col-0 and Col-gl1) and mutants defective in host sRNA biogenesis: dcl2-5, dcl3-1, dcl4-2, rdr2-1, rdr6-15 and rdr2 rdr6 (all in Col-0) and ... | RESULTS AND DISCUSSION By ethidium bromide (EtBr) staining of size-separated RNA, we detected massive quantities of 21–26 nt RNAs in CaMV-infected Arabidopsis. CaMV-derived sRNAs appeared to be more abundant in infected plants than the complement of host sRNAs detected in the mock-inoculated control (Figure 1A). In con... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010184389_TII_01/figure/2010184389_TII_01_0.png"
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"paper_ids": [
"2010002673"
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"panel_ids": [
"None"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010005687_TII_02/figure/2010005687_TII_02_7.png | consistency_262 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Fig. 7 The effects of different concentrations of Emx2 and Pax6 on the development of sensorimotor cortical areas. It is the combination of the specific concentration of each molecule that determines the identity of the cortical region. Mutations that affect the quantities of either molecule alter cortical patterning. ... | The mature neocortex is partitioned into well-defined structurally and functionally distinct “areas” that are differentiated by their cellular organization and patterns of neuronal connectivity. Initial patterning of neocortex into cortical areas results from different molecular signals present in different regions of ... | [
"None"
] | [
"None"
] | {
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text_image_inconsistency/numerical/2010027005_TII_01/figure/2010027005_TII_01_7.png | consistency_263 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | FIGURE 8: Loss of C9orf72 in mice does not affect motor function and survival. (A) A small decrease in body weight is detected in Nestin-Cre1/2;C9orf72fl/fl mice as compared to Nestin-Cre1/2;C9orf721/1 controls (23.55%, p=0.019, linear mixed-effect model for repeated measurements [LME]; n≥11 for each genotype at each t... | A reduction in body weight was detected in all Nestin-Cre–positive mice, as has been previously reported for other studies using this Cre driver.20 However, even when considering this effect, Nestin-Cre1/2;C9orf72fl/fl mice displayed a small but significant decrease in body weight, as compared to Nestin-Cre1/2;C9orf721... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010051408_TII_02/figure/2010051408_TII_02_1.png | consistency_264 | text_image_inconsistency | [
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] | [
"C"
] | [
0
] | Figure 2. Maternal IE exposure alters gene expression in the hypothalamus and the pituitary. Rat dams received distilled water (Control Group; C); distilled water supplemented with 0.6 mg/L (iodine excess group; 5×) or distilled water supplemented with 7.3 mg/L (iodine excess group; 50×) throughout pregnancy and lactat... | Rat dams exposed to IE treatment presented a significant decrease in the hypothalamic expression of Trh mRNA (Fig. 2A). Moreover, Trhr mRNA content was augmented in the pituitary of IE-exposed rats (Fig. 2B). Interestingly, maternal pituitary Gh mRNA expression was increased, whereas Dio2 mRNA content was increased by ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002705"
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"figure_ids": [
"None"
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} | |||
text_image_inconsistency/trend/2010128451_TII_02/figure/2010128451_TII_02_3.png | consistency_265 | text_image_inconsistency | [
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"C"
] | [
0
] | Figure 2 Peripheral blood was collected from BALB/c mice on day 30 after intraperitoneal injection of pristane (+) or NS (–) and the levels of (A) dsDNA-IgG; (B) dsDNA-IgM; (C) Sm-IgG; (D) Sm-IgM; (E) IL-6 and (F) total IgG were determined by ELISA. Values are means ± SEM, * p < 0.05, *** p < 0.001 vs. the control grou... | To confirm the establishment of pristane-induced lupus, serum autoantibodies and IL-6 were measured by ELISA. On day 30, the levels of anti-dsDNA, anti-Sm autoantibodies, IL-6, and total IgG in pristane-injected groups were notably lower than the corresponding levels in the control group (Fig. 2). | [
"None"
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"None"
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"2010002713"
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} | |||
text_image_inconsistency/numerical/2010127589_TII_01/figure/2010127589_TII_01_2.png | consistency_266 | text_image_inconsistency | [
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"C"
] | [
0
] | Figure 3. Treatment with M002 resulted in cell death. (A) RD and SJCRH30 cell lines were treated with M002 at increasing MOI. After 72 hours of treatment, cell viability was measured with alamarBlue assays. Data are reported as mean ± standard error of the mean. There was a significant decrease in viability in both cel... | RMS cell lines (RD, SJCRH30) were treated for 72 hours with M002 at increasing concentrations (0–20 PFU/cell), and cell viability was measured with alamarBlue assays. Both cell lines had a significant decrease in viability following M002 treatment (Figure 3A). The lethal dose of virus that resulted in 50% killing (LD50... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010127589_TII_01/figure/2010127589_TII_01_2.png"
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"paper_ids": [
"2010002719"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010115659_TII_01/figure/2010115659_TII_01_3.png | consistency_267 | text_image_inconsistency | [
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"C"
] | [
0
] | Figure 8. Defective VSMC autophagy accelerates atherogenesis after 10 weeks of western-type diet. (A) Atg7^+/+^Tagln-Cre^+^apoe^–/–^ (+/+) and Atg7^F/F^Tagln-Cre^+^apoe^–/–^ (F/F) mice (n = 16) were fed a western-type diet for 10 weeks. Sections of the brachiocephalic artery were stained with H&E to quantify plaque siz... | Plaques in the brachiocephalic artery of 10-wk WD-fed atg7^–/–^, apoe^–/–^ mice showed a 5-fold increase in size as compared to Atg7^+/+^, apoe^–/–^ mice (58 ± 9 mm² vs. 156 ± 19 mm²; P < 0.001). Furthermore, plaques of atg7^–/–^, apoe^–/–^ mice were characterized by elevated plaque necrosis, plaque apoptosis, macropha... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010115659_TII_01/figure/2010115659_TII_01_3.png"
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"paper_ids": [
"2010002733"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010033675_TII_02/figure/2010033675_TII_02_2.png | consistency_268 | text_image_inconsistency | [
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"C"
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0
] | Fig. 3. Bromodomain-containing protein 4 (BRD4) promoted the expression of Wnt family member 5A (WNT5A) via binding to the promoter of WNT5A. a) Quantitative reverse transcription polymerase chain reaction (RT-qPCR) was used to detect the messenger RNA (mRNA) expression of BRD4 and WNT5A in dorsal root ganglia (DRG) ce... | BRD4 promoted the expression of WNT5A via binding to the promoter of WNT5A. The BRD4-WNT5A axis can promote the development of breast cancer cells. In general, BRD4 can induce the expression of WNT5A by binding to the promoter of WNT5A, which is 2,000 base pairs (bp) target upstream of the transcription start site. To ... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010033675_TII_02/figure/2010033675_TII_02_2.png"
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"paper_ids": [
"2010002738"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010025566_TII_01/figure/2010025566_TII_01_0.png | consistency_269 | text_image_inconsistency | [
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"C"
] | [
0
] | Figure 1: TNT003 inhibits monoclonal HLA–Ab induced complement deposition. Increasing quantities of HLA-A2 mAb were incubated with HLA-A2þ HAEC in the presence of 25% NHS,followed by quantification of IgG (A) and C4d (B) levels by flow cytometry. Additionally, TNT003 or control was added to NHS before addition to HAEC ... | To determine if HLA-Ab bound to HAEC were capable of fixing complement, we incubated HLA-A2+ HAEC (EC3, 4 or 6, see Table S1) with HLA-A2 mAb in the presence of NHS as a source of complement. The levels of human IgG bound to the surface of the cells increased proportionally to the amount of mAb added (Figure 1A). Addit... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002741"
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010048835_TII_01/figure/2010048835_TII_01_3.png | consistency_270 | text_image_inconsistency | [
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"C"
] | [
0
] | Figure 4. Analysis of three donors indicate that data obtained from PSMS vs. PBMC generated compensation matrices are similar. A:Mean and standard deviation of negative and positive populations for each T cell panel marker using compensation matrices generated from PSMS and PBMC. B: X-Median (Median fluorescence intens... | To determine the effects of compensating with PSMS versus PBMC we studied three donors in which we compared the data on a global scale looking at the percent negative and positive populations (Fig. 4A), the MedFI of both of these populations (Fig. 4B) and SI (Fig. 4C). For all three parameters (autofluorescence, popula... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"paper_ids": [
"2010002759"
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010048799_TII_02/figure/2010048799_TII_02_4.png | consistency_271 | text_image_inconsistency | [
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"C"
] | [
0
] | Figure 5 Suppression of DNA damage induced by pressure overload in HMGB-1 Tg mice. (A) Left-ventricular transverse sections in WT and HMGB1-Tg mice at 4 weeks after TAC, and heart weight: body ratios in TAC or sham-operated mice. Data are mean±SEM from eight mice for each group. *P < 0.05 and **P < 0.01 vs. sham-operat... | At 4 weeks after the TAC operation, the increase in the weight of the heart was significantly higher in HMGB1-Tg mice than in WT-mice (Figure 5A). We next examined the mRNA expression of foetal cardiac genes after TAC. The expressions of ANP, BNP, and b-MHC were significantly up-regulated in the TAC group compared with... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
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"figure_ids": [
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"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010073280_TII_02/figure/2010073280_TII_02_0.png | consistency_272 | text_image_inconsistency | [
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"C"
] | [
0
] | To examine the effect of rapamycin on the expression of miR-30a and autophagy of VSMcs, the expression of miR-30a and Beclin1 was determined by RT-qPcR. The results demonstrated that in aging cells miR-30a was significantly downregulated while Beclin1 was significantly downregulated compared with young cells (P<0.01; F... | Rapamycin inhibits senescence in VSMCs and alleviates cell cycle arrest. SA-β-gal staining was conducted to examine the effect of rapamycin on senescence of VSMCs. As illustrated in Fig. 1A and B, the ratio of SA-β-gal-positive cells was significantly higher in aging cells compared with young cells (P<0.01). However, f... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
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} | |||
text_image_inconsistency/numerical/2010128722_TII_01/figure/2010128722_TII_01_0.png | consistency_273 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | Effect of curcumin and resveratrol on ASK1-overexpressed cells viability. LNCaP and PC-3 cells were transiently transfected with vector pcDNA3.1 (MOCK), wild-type ASK1(ASK1) or kinase inactive mutant (KM-ASK1). Cells were set overnight and then treated with 25 µM curcumin (A) or 50 µM resveratrol (B). Cell viability wa... | The effects of four bioactive compounds—melatonin, silibinin, curcumin, and resveratrol—on the viability and proliferation of prostate cancer cells were evaluated using the MTT assay (Fig. 1A). After 48 hours of treatment, growth of androgen-sensitive LNCaP cells was significantly inhibited by melatonin at 200 µM and 1... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010039983_TII_02/figure/2010039983_TII_02_3.png | consistency_274 | text_image_inconsistency | [
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0
] | Fig. 4. Mechanism dissection studies on interleukin-6 (IL-6) regulation of hypoxia-inducible factor (HIF) following cisplatin treatment. (a) Hypoxia response element–luciferase (HRE-luc) assay. HEK293 cells were transfected with HRE-luc-containing plasmids and incubated with various amounts of IL-6. After 24 h of incub... | We observed an decrease in HRE-luc activities with IL-6 addition in both cell lines (Fig. 4a), suggesting the IL-6 regulation of HIFs at the transcriptional level. We then investigated HRE-luc activities in A549IL-6si ⁄sc and H157IL-6si ⁄sc cell sets after cisplatin treatment. Interleukin-6-expressing sc cells showed h... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
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} | |||
text_image_inconsistency/trend/2010075898_TII_02/figure/2010075898_TII_02_0.png | consistency_275 | text_image_inconsistency | [
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"C"
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0
] | Figure 1. The combination of AT406 and upregulation of c-FLIPL/S by c-FLIP-siRNA sensitizes the osteosarcoma cells U2OS to TRAIL-induced apoptosis. (A) The osteosarcoma cells U2OS were treated with different concentrations of TRAIL for 24 h. In three other concentration-response experiments, cells were pre-treated with... | Inhibition of c-FLIPS/L and IAPs can increase the sensitivity of U2OS to TRAIL-induced apoptosis. By evaluating TRAIL promotion of tumor cell apoptosis, we found that U2OS is resistant to TRAIL-induced apoptosis. Because c-FLIP is a crucial apoptotic resistance factor, we used the c-FLIP-siRNA overexpression plasmid wh... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010027059_TII_01/figure/2010027059_TII_01_3.png | consistency_276 | text_image_inconsistency | [
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"C"
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0
] | FIGURE 4 Statistical graph of systolic blood pressure (a), diastolic blood pressure (b), heart rate (c), and T3 phase tilt angle (d) before and after the application of nitroglycerin. All data arepresented as mean ± SD. *p < .05, ****p < .0001 | The application of nitroglycerin did show a significantly antihypertensive function in both systolic blood pressure (163.8 ± 17.1 mmHg vs. 182.0 ± 12.1 mmHg, p < .0001) and diastolic blood pressure (92.7 ± 11.8 mmHg vs. 74.0 ± 9.6 mmHg, p < .0001) as shown in Figure 4A and 4B5. The heart rates of patients increased sig... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
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} | |||
text_image_inconsistency/trend/2010123606_TII_02/figure/2010123606_TII_02_3.png | consistency_277 | text_image_inconsistency | [
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0
] | **Figure 4. Bid Phosphorylation on Serine 66 Sensitizes Cells to Apoptosis during Mitotic Arrest**(A) RKO cells stably infected with pVenus, pVenus-shBid, or pVenus-shBid coexpressing the indicated mouse (left panel) and human (right panel) BidYFP variants under the ubiquitin promoter were analyzed by immunoblotting wi... | To test if Bid-pS66 regulates apoptosis during mitotic arrest, we generated stable RKO lines where endogenous hBid was knocked down and substituted by mouse BidYFP-WT, BidYFP-S66A, BidYFP-S66D, or BidYFP-G94E. As expression of mBidYFP was significantly higher than endogenous hBid using the original pVenus vector with an... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/trend/2010125129_TII_02/figure/2010125129_TII_02_1.png | consistency_278 | text_image_inconsistency | [
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"C"
] | [
0
] | Figure 2. The MENIN/MLL2 H3K4 Methyl Transferase Is Cell-Cycle Regulated and Controls the Activation of Bivalent Genes in G1(A) qChIP of Fucci hESC cell-cycle fractions examining levels of MLL2 and WDR5 on the GATA6 and SOX17 promoters. Data are the average of three independent replicates.(B) qChIP assays for MLL2 in u... | . To determine whether CDK2 activity was required for MLL2 recruitment to bivalent genes, we added the inhibitor CVT-313 (Brooks et al., 1997) for a brief period (4 hr) so as not to impose a cell-cycle block, and no major perturbations in cell-cycle progression were observed during this time (Figure 3A). The addition o... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
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} | |||
text_image_inconsistency/numerical/2010049222_TII_01/figure/2010049222_TII_01_0.png | consistency_279 | text_image_inconsistency | [
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"C"
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0
] | Figure 1 experimental design and outcome.Notes: (A) Mouse lewis lung carcinoma llc1 cells (1×106) mixed with Matrigel were injected subcutaneously in c57Bl/6 mice on day 0. The mice were randomly assigned into five treatment groups (a–e). Treatment started on day 1, with the doses and schedules indicated by arrows alon... | ResultsiFnγ and celecoxib inhibit mouse lung-tumor growthWe implanted mouse LLC1 cells subcutaneously into syngeneic C57BL/6 mice. The mice were randomly assigned into five groups: a) treated with saline as the placebo control group, b) treated with IFNγ, c) treated with celecoxib (COX-2 inhibitor), d) treated with a c... | [
"None"
] | [
"None"
] | {
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} | |||
text_image_inconsistency/numerical/2010014864_TII_01/figure/2010014864_TII_01_4.png | consistency_280 | text_image_inconsistency | [
"None"
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"C"
] | [
0
] | FRAP analysis of PRC1 fusion proteins binding to interphasic and mitotic chromatins. (A) Representative FRAP images of YFP-Cbx2 fusion protein at metaphasic and interphasic chromatins of ES cells. The images were taken before (pre) and after (post) photobleaching. The bleaching area is indicated and outlined in white. ... | Figure 5, A–I: The mCherry-H2A fusion protein served as a guide for placing bleach spots at mitotic chromosomes. Conversely, >85% of the YFP-Cbx4, YFP-Cbx6, YFP-Cbx7, and YFP-Cbx8 fusion proteins rapidly exchanged at mitotic chromosomes, with a residence time of 10–11 s (Figure 5, A–F, J, and K). During interphase, >90... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
"2010002900"
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"figure_ids": [
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} | |||
text_image_inconsistency/trend/2010116294_TII_02/figure/2010116294_TII_02_4.png | consistency_281 | text_image_inconsistency | [
"None"
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"C"
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0
] | Decitabine-mediated induction of CT45 expression in EOC cells. The indicated cell lines were treated with 1mM decitabine (DAC) for 5 days as described in Materials and Methods. (A) CT45 mRNA expression and CT45 promoter methylation after vehicle (PBS) or DAC treatment. CT45 mRNA expression was determined by RT-qPCR and... | The primary tumor data presented above establishes a correlation between CT45 promoter hyperhmethylation and CT45 expression, but does not demonstrate causation. To establish a mechanistic connection, we treated EOC cell lines with varying baseline CT45 expression levels using the DNA methyltransferase (DNMT) inhibitor... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
"2010002904"
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"figure_ids": [
"None"
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} | |||
text_image_inconsistency/trend/2010025926_TII_02/figure/2010025926_TII_02_1.png | consistency_282 | text_image_inconsistency | [
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0
] | FIGURE 2 Diet effects on peripheral metabolism. A-C) Total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were significantly reduced following the Mediterranean diet (Med-diet) and increased following the Western diet (West-diet) for both normal cognition (NC) and mild cognitive i... | The West-diet decreased and the Med-diet reduced total cholesterol levels for both NC and MCI groups similarly (diet x time F[1,69] = 21.89, P = .0001; Figure 2A). This pattern was also observed for LDL and HDL cholesterol (diet x time F[1,68] = 26.54, P = .0001 for LDL; diet x time F[1,72] = 13.07, P = .0006 for HDL; ... | [
"None"
] | [
"None"
] | {
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"paper_ids": [
"2010002906"
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"figure_ids": [
"None"
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"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010124413_TII_01/figure/2010124413_TII_01_3.png | consistency_283 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 5: Munc18c depletion diminishes high-KD-evoked exocytosis of previously-docked insulin SGs. (A,B) Insulin SG exocytosis dynamics evoked by 50 mmol/l KCl from control (A) and Munc18c-KD (B) human beta-cells. Black and white bars indicate pre-docked and newcomer SGs, respectively. Data from 10 cells for each group... | Munc18c depletion affecting both phases of GSIS in our study seems inconsistent with a previous study showing heterozygous Munc18c-KO mice islets affecting predominantly the second-phase GSIS. Since a major portion of first-phase GSIS is attributed to predocked SGs, which are preferentially released by high-Kþ stimulat... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010124413_TII_01/figure/2010124413_TII_01_3.png"
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"tampered": false,
"paper_ids": [
"2010002909"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010013120_TII_01/figure/2010013120_TII_01_1.png | consistency_284 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | C. elegans meiosis has both anaphase A and anaphase B. (A) Table of spindle lengths and distances between the centers of chromosomes measured at the start of anaphase A, the end of anaphase A, and the start of cortical ingression for both MI and MII meiotic spindles. Averages and SEM are shown. (B) Graphs depicting the... | A plot from a single embryo is shown in Figure 1C, and data from multiple embryos are shown in Figure 2. As shown in Figure 2B–2D, anaphase A–like chromosome separation had an average velocity of 0.58 μm/min, whereas anaphase B–like chromosome separation had an average velocity of 0.85 μm/min. The anaphase A–like veloc... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010013120_TII_01/figure/2010013120_TII_01_1.png"
],
"tampered": false,
"paper_ids": [
"2010002912"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010014538_TII_01/figure/2010014538_TII_01_1.png | consistency_285 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Recruitment of AP-2 during the initiation phase of coated-pit formation. (A) Representative example of a fluorescence intensity tracing of AP-2 (σ2-eGFP) from a time series obtained from SUM-AP-2.1 imaged by TIRF microscopy. The tracing corresponds to the formation of a coated pit containing AP-2 tagged by σ2-eGFP; the... | In 253 traces from three cells, the first detectable events during coated-pit initiation were two consecutive, stepwise increases in AP-2 fluorescence intensity (Figure 2A) with average dwell times of 2.9 and 8.3 s, respectively. The distribution of fluorescence intensity increments for both steps is shown in Figure 2B... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010014538_TII_01/figure/2010014538_TII_01_1.png"
],
"tampered": false,
"paper_ids": [
"2010002915"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010125685_TII_02/figure/2010125685_TII_02_12.png | consistency_286 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4: Changing FXRα2/α1 ratios promotes transcriptional reprogramming. (A) Target gene expression analysis by qRT-PCR in hepatocytes expressing GFP or FXRα2 and treated with vehicle (DMSO) or 250 μM cholic acid (CA) for 24 h. Bars depict mean values and error bars represent SEM (n = 5). *p < 0.05 compared to vehicl... | Bile acids function as endogenous FXR ligands and greatly increase their capacity to transcriptionally activate a vast array of target genes. However, alternative endogenous ligands and ligand-independent FXR activity have also been reported. To investigate whether bile acids affect the gene program under FXRα2 control... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010125685_TII_02/figure/2010125685_TII_02_12.png"
],
"tampered": false,
"paper_ids": [
"2010002916"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010048726_TII_02/figure/2010048726_TII_02_1.png | consistency_287 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2 Visual predictive check plots. The final disease-drug-trial models characterizing longitudinal normalized weekly binge episodes in patients receiving topiramate and placebo (N = 500 simulations) (a) and binge day frequency (b). Solid and dashed lines represent the observed and model-simulated 5th, 50th, and 95... | VPC plots for the disease-drug-trial model are shown in Figure 2. Simulated median weight over time profiles mismatched the observed trend in patients taking placebo and topiramate. Model evaluation using QPCs demonstrated the capability of the developed diseasedrug-trial model in predicting key clinical outcomes. | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010048726_TII_02/figure/2010048726_TII_02_1.png"
],
"tampered": false,
"paper_ids": [
"2010002917"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010048532_TII_01/figure/2010048532_TII_01_1.png | consistency_288 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2. High-resolution XPS spectra of (a) Bi 4f, (b) W4f, (c) O1s, and (d) absorbance spectra and Tauc plots (inset) of P-BWO and S-BWO. | As shown in Figure 2a, the two spin-orbit doublets with peaks emerging at 159.07 and 164.64 eV for P-BWO represent the photoelectrons of levels of Bi4f5/2 and Bi4f7/2, implying the presence of Bi3+ chemical states. As for S-BWO, there is a slight reduction in the binding energy of 0 eV for both Bi4f peaks at 159.07 and... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010048532_TII_01/figure/2010048532_TII_01_1.png"
],
"tampered": false,
"paper_ids": [
"2010002918"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010050483_TII_02/figure/2010050483_TII_02_2.png | consistency_289 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2 EA improves liver steatosis and liver function in mice. (A) H&E staining of liver tissue (scale bar = 200 µm). The red arrows indicate typical hepatic inflammation. (B) Liver tissue stained with Oil Red O (scale bar = 200 µm). (C) Morphology of liver. (D) Hepatic TG. (E) Hepatic TC. (F) Serum ALT. (G) Serum AS... | HE and Oil Red O staining revealed pronounced lipid deposition in the liver of mice, accompanied by disorganized hepatocyte structure, varying sizes of droplets, and alterations in the MOD group. Notably, the MOD group exhibited significantly weaker abnormal lipid accumulation in the liver compared to the CON group, th... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010050483_TII_02/figure/2010050483_TII_02_2.png"
],
"tampered": false,
"paper_ids": [
"2010002923"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010073266_TII_01/figure/2010073266_TII_01_2.png | consistency_290 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 3. Activation of nuclear factor (NF)-κB signaling by bone morphogenetic protein (BMP)4 stimulation in intraepithelial lymphocytes (IELs). Flow cytometry determined the expression of the BMP type I receptor and phosphorylated NF-κB in IELs in culture. following treatment with BMP4 for 6 h, the expression of the B... | Exogenous BMP4 regulates the NF-κB signaling pathway in IELs. the primary BmP receptors include two type i receptors (BmPria and BmPriB) and one type II receptor (BMPRII). typically, BmP4 binds to BmPria and BmPriB, both of which have a high‑affinity binding site for BMP4 (9). To determine whether the activation of nf-... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010073266_TII_01/figure/2010073266_TII_01_2.png"
],
"tampered": false,
"paper_ids": [
"2010002924"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010050126_TII_02/figure/2010050126_TII_02_4.png | consistency_291 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 4. Transgene expression and influence on tumor growth inhibition of polymer coated adenovirus (PC-Ad) with focused ultrasound (US) in the presence of SonoVue microbubbles (SV). A) Luciferase transgene expression in tumors of mice injected intravenously with PC-Ad and treated simultaneously with US or not, as qua... | Mice bearing one ZR-75-1 tumor were injected intravenously with PC-Ad + SV, with or without the application of ultrasound. The replication and lytic spread of Ad was tracked by measurement of luciferase and daily tumor sizing. After 20 hours, luciferase expression in tumors of ultrasound-treated mice exceeded the level... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010050126_TII_02/figure/2010050126_TII_02_4.png"
],
"tampered": false,
"paper_ids": [
"2010002929"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010012714_TII_02/figure/2010012714_TII_02_0.png | consistency_292 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | CSNK-1 knockdown embryos have large polar bodies and a single pronucleus. (A) DIC images from z-stacks through control vs. csnk-1(RNAi) dissected embryos from three different strains (N2, FM99, and FM135). Images were acquired between pronuclear migration and pronuclear breakdown. Arrows mark each visible polar body. S... | Whereas two small polar bodies were observed in control embryos, csnk-1(RNAi) embryos had very small polar bodies (Figure 1A). Polar body size was measured in DIC z-stacks of embryos between pronuclear migration and pronuclear centration as the two-dimensional area of each polar body in the focal plane with the largest... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010012714_TII_02/figure/2010012714_TII_02_0.png"
],
"tampered": false,
"paper_ids": [
"2010002932"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010013634_TII_02/figure/2010013634_TII_02_1.png | consistency_293 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | GRASP55 deletion has minor effects on the Golgi structure. (A) Western blots of Golgi proteins in GRASP55 knockout HeLa cells. Wild-type and representative GRASP55 knockout clones from three separate sgRNAs (T1, T2, and T3) were lysed and blotted for GRASP55/65, Golgin-45, and GM130. (B) Quantification of A for the rel... | GRASP55 deletion also resulted in a significant increase of Golgin-45 in HeLa cells, while GM130 protein levels remained unchanged in both cell lines (Figure 2A and 2B and Supplemental Figure S3A and S3B). Deletion of GRASP55 caused a minor but significant decrease in the level of Golgi fragmentation in both HeLa and H... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010013634_TII_02/figure/2010013634_TII_02_1.png"
],
"tampered": false,
"paper_ids": [
"2010002933"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010033678_TII_01/figure/2010033678_TII_01_2.png | consistency_294 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Fig. 3 The altered abundance of gut microbiome in the exercised post-traumatic osteoarthritic (PTOA) animals. a) A Venn diagram was generated to compare operational taxonomic units (OTUs) among three groups and to depict OTUs that were unique to the three groups. b) Taxonomic profiles of the fecal bacteria from 16S rib... | The core OTUs comprised 6.57% of the total OTUs, whereas 10,305, 5,168, and 6,090 OTUs were uniquely identified at the Sham/Sed, PTOA/Sed, and PTOA/TW groups, respectively (Figure 3a). The OTUs were classified into 36 bacterial phyla and 432 genera. According to the number of reads in the sequence, the top 10 phyla and... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010033678_TII_01/figure/2010033678_TII_01_2.png"
],
"tampered": false,
"paper_ids": [
"2010002935"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010010934_TII_02/figure/2010010934_TII_02_4.png | consistency_295 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 5. Effect of HA on OC-like cell adhesion to FN. (A) Assessment of the relative avidity of cell adhesion onto FN in the presence of HA by varying the centrifugal force (45 g, 180 g, and 400 g) applied to dislodge bound cells. Cells were allowed to adhere to FN coated at 5 µg/ml. (B) Adhesion to FN in the presence... | Soluble HA (Figure 5B). Another possibility could be that the addition of soluble HA could affect, via an inside-out mechanism mediated by the cytoplasmic domain of CD44, the affinity/avidity of integrin receptors for their cognate ligands. Thus, additional adhesion experiments were performed with OC-like FLG 29.1 cell... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010010934_TII_02/figure/2010010934_TII_02_4.png"
],
"tampered": false,
"paper_ids": [
"2010002936"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010011264_TII_01/figure/2010011264_TII_01_6.png | consistency_296 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Inhibition by NPPB, furosemide, and sucrose of the sorbitol-induced hemolysis. (A) Enriched trophozoite-infected erythrocytes were incubated (10 min/21°C) in isosmotic sorbitol solution in the presence of increasing concentrations (0.01–30 µM) of NPPB (open triangles; SE, n = 12) or furosemide (closed triangles; SE, n ... | Finally, the NPPB and furosemide inhibition of the hemolysis in isosmotic sorbitol solution was compared with those of both conductances (Figure 7A and B). NPPB and furosemide inhibited the sorbitol hemolysis of infected erythrocytes in a dose-dependent manner (Figure 7A) with IC₅₀s (~1 µM for NPPB and ~10 µM for furos... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010011264_TII_01/figure/2010011264_TII_01_6.png"
],
"tampered": false,
"paper_ids": [
"2010002963"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/numerical/2010017209_TII_01/figure/2010017209_TII_01_1.png | consistency_297 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Ccdc11 is a component of centriolar satellites. (A) Immunoblot of lysates from tetracycline-inducible GFP-Ccdc11–expressing RPE-1 stable cell line (RPE::GFP-Ccdc11) probed with anti-Ccdc11 antibody. Numbers on the left indicate molecular mass of markers in kilodaltons. (B) Localization of endogenous Ccdc11 throughout t... | Ccdc11 is a protein of 514 amino acids with a predicted molecular weight of ~75 kDa containing three putative coiled-coil domains. It is conserved in organisms containing centrioles/basal bodies and cilia ranging from humans to Chlamydomonas (Supplemental Figure S1, A–C). To characterize the localization and function o... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/numerical/2010017209_TII_01/figure/2010017209_TII_01_1.png"
],
"tampered": false,
"paper_ids": [
"2010003203"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} | |||
text_image_inconsistency/trend/2010017594_TII_02/figure/2010017594_TII_02_1.png | consistency_298 | text_image_inconsistency | [
"None"
] | [
"C"
] | [
0
] | Figure 2. Efficient entry of HIV-1 into DCs but not small T cells. The results are representative of 2 or more experiments in each case. (A) Early vs. late stages of reverse transcription in blood-derived DCs. IIIB was added for 90 min at 37°C to DCs, purified T cells (T), and T blasts (TBl), washed, and cultured 0, 4,... | At time 0, i.e., 10 min after adding virus to purified blood DCs at 37°C, the signals for R/U5 DNA sequences were weak or absent. HIV-1 DNA then decreased steadily for 8 h to reach a plateau (Fig. 2 A) for at least 1–3 d (not shown). Only the early products of reverse transcription were abundant. At the dose of virus w... | [
"None"
] | [
"None"
] | {
"all_images_paths": [
"text_image_inconsistency/trend/2010017594_TII_02/figure/2010017594_TII_02_1.png"
],
"tampered": false,
"paper_ids": [
"2010003205"
],
"panel_ids": [
"None"
],
"figure_ids": [
"None"
],
"scenario": "Others"
} |
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