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Answer the following medical question with one of the provided options:
Q:A 24-year-old woman is in the intensive care unit for the management of a severe acute asthma exacerbation. She is currently intubated and sedated, and she is receiving intravenous steroids, continuous nebulized beta-agonists, and anticholinergic therapy via breathing treatments. On hospital day 2, she has a new feve...
C: Inactivation of the medicine in the target tissue
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Q:A 53-year-old Asian woman comes to the physician because of a 2-month history of severe pain in her right leg while walking. She used to be able to walk a half-mile (800-m) to the grocery store but has been unable to walk 200 meters without stopping because of the pain over the past month. She can continue to walk af...
D: Ankle-brachial index
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Q:A 27-year-old woman develops progressive difficulty breathing after a long day of chores in a dusty house. These chores included brushing the family dog, vacuuming, dusting, and sweeping. She occasionally gets these episodes once or twice a year and has her medication on hand. Her symptoms are reversed by inhaling a ...
B: Leukotrienes
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Q:Nine healthy subjects participate in a study of gastric secretions. Subjects are asked to eat a meal at hour 0, at which time the pH of stomach contents and rate of stomach acid secretions are measured over the next 4 hours. Results of the study are shown. Which of the following mediators is most active at point A in...
E: Acetylcholine
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Q:A 43-year-old Caucasian woman is admitted to the hospital with acute onset right upper quadrant (RUQ) pain. The pain started 6 hours ago after the patient had a large meal at a birthday party and has progressively worsened. She recalls having similar pain before but not so intense. No significant past medical history...
C: Laparoscopic cholecystectomy
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Q:A 38-year-old man comes to the physician because of severe muscle pain and swelling of his eyelids for 3 days. He has also had fever and chills during this period. For the last 2 days, he has had severe pain in his mouth while chewing. He had an episode of diarrhea a month ago for which he did not seek medical care. ...
B: Cooking meat to 71°C (160°F)
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Q:A 28-year-old man comes to the physician for a pre-employment examination. He has no history of serious illness and takes no medications. A screening blood test is performed in which peptides are added to the sample to stimulate in vitro production of interferon-gamma, which is then measured using an enzyme-linked im...
D: Mycobacterium tuberculosis
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Q:A 23-year-old woman comes to the physician because of a 5-month history of a pruritic rash on the bilateral upper extremities. She has no history of serious illness and takes no medications. A skin biopsy of the rash shows intraepidermal accumulation of edematous fluid and widening of intercellular spaces between ker...
E: Eczematous dermatitis
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Q:A 52-year-old man with a 20+ year history of smoking comes in today to talk about quitting. His wife has recently been trying to quit, and she wants him to quit with her. He has been resistant in the past, but he is now very willing to talk with you about it. Today, he seems like he really wants to make a change. Wha...
C: Preparation
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Q:A 28-year-old woman is brought into the clinic by her husband with concerns that she might be depressed. She delivered a healthy newborn a week and a half ago without any complications. Since then, she has been having trouble sleeping, eating poorly, and has stopped playing with the baby. The patient says she feels l...
A: Reassurance
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Q:A 51-year-old man presents to the emergency department with complaints of upper abdominal pain for the last several hours. He says that the pain travels to his back and is less severe when he leans forward. He is diagnosed with acute pancreatitis following enzyme analysis and CT scan of the abdomen and is subsequentl...
D: Endoscopic drainage
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Q:A 13-year-old boy is brought to the physician because of a 5-day history of a rash on his chest and back. His mother initially noticed only a few lesions on his back, but since then the rash has spread to his chest. His family returned from a trip to the Caribbean 2 weeks ago. His mother started using a new laundry d...
C: Increased growth of Malassezia globosa
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Q:A 72-year-old woman is brought to the emergency department because of increasing abdominal pain for 6 hours. The pain is dull and diffuse over her abdomen and radiates to her lower back bilaterally. Three weeks ago, she was diagnosed with atrial fibrillation and started on warfarin. Her only other medication is 1 g o...
D: Phytonadione and prothrombin complex concentrate
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Q:A 36-year-old man presents to a psychiatrist for management of nicotine dependence. He has been a heavy smoker for the past 20 years. He has unsuccessfully attempted to quit smoking many times. He has seen multiple physicians for nicotine dependence. They prescribed nicotine replacement therapy and varenicline. He ha...
B: Clonidine
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Q:A physician attempts to study cirrhosis in his state. Using a registry of admitted patients over the last 10 years at the local hospital, he isolates all patients who have been diagnosed with cirrhosis. Subsequently, he contacts this group of patients, asking them to complete a survey assessing their prior exposure t...
A: Case-control study
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Q:A 17-year-old male presents to your office complaining of polyuria, polydipsia, and unintentional weight loss of 12 pounds over the past 3 months. On physical examination, the patient is tachypneic with labored breathing. Which of the following electrolyte abnormalities would you most likely observe in this patient??...
B: Hyperkalemia
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Q:A 54-year-old man comes to the physician because of generalized fatigue and numbness of his legs and toes for 5 months. He has hypertension and hypercholesterolemia. He underwent a partial gastrectomy for peptic ulcer disease 15 years ago. Current medications include amlodipine and atorvastatin. He is a painter. His ...
C: Elevated methylmalonic acid levels
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Q:A 5-year-old male is brought to his pediatrician after recurrent, prolonged upper respiratory infections over a period of several months. Physical exam reveals petechiae on the patient’s legs and arms. Laboratory studies show hemoglobin: 10 g/L, platelet count: 35,000/mm^3, leukocyte count: 6,600/mm^3. A bone marrow ...
C: CD19, CD10
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Q:The objective of one case-control study was to assess whether a history of past trauma represents a risk factor for the development of spondyloarthritis. Cases of spondyloarthritis were compared with a random sample taken from the general population in regards to a history of prior trauma. This kind of history, which...
A: If the outcome is ascertained through electronic health records
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Q:A 67-year-old man presents to the emergency department with trouble urinating. The patient states that in general he has had difficulty urinating but recently, it has taken significant effort for him to initiate a urinary stream. He finds himself unable to completely void and states he has suprapubic tenderness as a ...
B: Medication-induced symptoms
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Q:A 26-year-old woman, gravida 2, para 1, at 26 weeks’ gestation, comes to the emergency department because of pain and swelling in her right calf. Physical examination shows an increased circumference of the right calf. The leg is warm and tender on palpation. Dorsiflexion of the right foot elicits calf pain. An ultra...
C: Heparin
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Q:A 4-year-old boy is brought to the physician by his mother because of generalized weakness and difficulty walking for the past month. Laboratory studies show a hemoglobin concentration of 6.6 g/dL, mean corpuscular volume of 74 μm3, platelet count of 150,000/mm3, and serum total bilirubin of 2 mg/dl. An MRI of the sp...
E: Beta-thalassemia "
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Q:A 32-year-old woman comes to the physician because of weight gain, generalized weakness, and irregular menstrual cycles for the past 16 months. She began having symptoms of insomnia and depression 10 months ago. More recently, she has been having difficulties rising from a chair. She has a 2-year history of hypertens...
C: High-dose dexamethasone suppression test
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Q:A 43-year-old woman is found in the hospital to have a plasma sodium concentration of 126 mg/dL. She was hospitalized after she expressed suicidal ideations and was started on a medication for major depressive disorder. Her past medical history is significant for diabetes for which she is currently taking metformin. ...
D: Located in the hypothalamus
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Q:A 41-year-old nulliparous woman comes to the physician for an annual pelvic examination and Pap smear. Over the past year she has been feeling healthy. She is sexually active and uses an intrauterine device with copper for contraception. She has smoked one pack of cigarettes daily for 20 years. She is 160 cm (5 ft 3 ...
A: Leiomyoma
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Q:A 52-year-old man comes to the physician for a routine health maintenance examination. He feels well. His blood pressure is 125/70 mm Hg. His glomerular filtration rate is calculated to be 105 mL/min/1.73 m2 and glucose clearance is calculated to be 103 mL/min. This patient is most likely being treated with which of ...
B: Canagliflozin
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Q:An 18-month-old boy is brought in by his parents for a routine check-up. The parents state that the patient still has not had any language development, and they are concerned about developmental delay. Of note, they have also noticed that the patient’s facial features have changed significantly in the last year. The ...
D: Nonsense mutation
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Q:A 29-year-old man is brought to the emergency department 20 minutes after being stabbed in the left thigh. His pulse is 110/min, respirations are 20/min, and blood pressure is 110/70 mm Hg. Examination shows a 2-cm wound overlying a pulsatile mass on the left anterior thigh, 4 cm below the inguinal crease. A thrill i...
B: High-output cardiac failure
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Q:A 69-year-old man presents to his primary care physician for pain when he walks. He states that the pain is the worst in his left great toe but is also present in his hips and knees. He says that his symptoms are worse with activity and tend to improve with rest. His symptoms have progressively worsened over the past...
A: Osteoarthritis
Answer the following medical question with one of the provided options:
Q:A 51-year-old woman presents to your office with 2 weeks of fatigue and generalized weakness. She has a past medical history of diabetes, hypertension, and hyperlipidemia. She was recently diagnosed with rheumatoid arthritis and started on disease-modifying therapy. She states she has felt less able to do things she ...
D: Medication side effect
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Q:A 34-year-old man presents with acute-onset fever and weakness followed by shifting neurologic deficits (aphasia, motor deficits), which have lasted for a few days. His relatives add that his quantity of urine has reduced significantly over the last few days. He has never had any similar symptoms. Laboratory findings...
E: Plasmapheresis is the treatment of choice.
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Q:A 38-year-old man comes to the physician because of a 1-month history of fever and a cough productive of a moderate amount of yellowish sputum. He has had a 6-kg (13-lb) weight loss during this period. He emigrated from the Middle East around 2 years ago. His father died of lung cancer at the age of 54 years. He has ...
C: Collect sputum specimens for acid-fast bacilli smear microscopy, culture, and nucleic acid amplification
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Q:A 5-year-old girl is brought to the physician by her mother for a 6-week history of fatigue, fever, and recurrent epistaxis. She has a history of duodenal atresia and an atrioventricular septal defect. She is at the 5th percentile for height and 30th percentile for weight. Physical examination shows painless cervical...
A: Meiotic nondisjunction
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Q:A 27-year-old woman, gravida 2, para 1, at 37 weeks' gestation is admitted to the hospital in active labor. She has received routine prenatal care, but she has not been tested for group B streptococcal (GBS) colonization. Pregnancy and delivery of her first child were complicated by an infection with GBS that resulte...
C: Administer intrapartum intravenous penicillin
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Q:A 55-year-old woman presents with diarrhea and a rash. She reports having some painful reddish nodules on her legs that she noticed a week ago. She also has been having loose stools associated with cramping lower abdominal pain for the past month. This is associated with an urgency to defecate, and defecation helps r...
B: Infection
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Q:A 7-year-old boy presents to the emergency department with several days of high fever accompanied by runny nose, cough, and red itchy eyes. Upon further history, you learn that the family is undocumented and has not had access to primary health services. Upon physical examination you see a red, slightly bumpy rash ex...
E: Koplik spots
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Q:A 75-year-old female patient comes to the emergency department with altered mental status. She is brought in by her daughter with whom the patient lives. The patient’s daughter said they were watching TV when her mother became unresponsive. On exam the patient withdraws to pain but does not open her eyes or speak. An...
C: Grapefruit juice
Answer the following medical question with one of the provided options:
Q:A 25-year-old gravida 1 para 0 woman visits an OB/GYN for her first prenatal visit and to establish care. She is concerned about the costs related to future prenatal visits, medications, procedures, and the delivery. She has no type of health insurance through her work and has previously been denied coverage by publi...
B: She may be eligible for Medicaid because she is pregnant
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Q:A 19-year-old male with cystic fibrosis is evaluated in the clinic for regular health maintenance. He is compliant with his respiratory therapy, but states that he often "forgets" to take the medications before he eats. A panel of labs is drawn which reveals a moderate vitamin D deficiency. Which of the following ele...
D: Decreased calcium and decreased phosphate
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Q:A 57-year-old male presents with a primary complaint of erectile dysfunction. After proper evaluation, the patient is started on daily administration of sildenafil. This medication directly causes accumulation of which of the following intracellular mediators?? {'A': 'Ca2+', 'B': 'cGMP', 'C': 'AMP', 'D': 'NO', 'E': '...
B: cGMP
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Q:A 32-year-old Caucasian female is admitted to the emergency department with a 48-hour history of severe and diffuse abdominal pain, nausea, vomiting, and constipation. Her personal history is unremarkable except for an ectopic pregnancy 5 years ago. Upon admission, she is found to have a blood pressure of 120/60 mm H...
C: Adhesions
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Q:A 32-year-old woman presents with three-days of vaginal burning, itching, and pain with intercourse. She is in a monogamous relationship with her husband and has an intrauterine device for contraception. Her past medical history is unremarkable, except for recently being treated with antibiotics for sinusitis. Pelvic...
A: Fluconazole
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Q:A 2-week-old female newborn is brought to the physician for the evaluation of red eyes with discharge for 2 days. She was born at 39 weeks' gestation to a 22-year-old woman. Pregnancy and delivery were uncomplicated. The mother received irregular prenatal care during the second half of the pregnancy. The newborn weig...
D: Oral erythromycin administration
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Q:A 40-year-old woman was admitted to the surgical service after an uncomplicated appendectomy. She underwent surgery yesterday and had an uneventful postoperative course. However, she now complains that she is unable to completely void. She also complains of pain in the suprapubic area. You examine her and confirm the...
E: Catheterization
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Q:A 42-year-old woman presents to her family physician with a headache. The patient reports that the symptoms started about 2 hours ago when she woke up and have not improved. She states the pain is moderate, throbbing, tight in character, and is located in the occipital region bilaterally. The patient denies any visua...
E: Recommend lifestyle changes, relaxation techniques, and massage therapy
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Q:A 27-year-old man comes to the physician for a follow-up examination. Paroxetine therapy was initiated 6 weeks ago for a major depressive episode. He now feels much better and says he is delighted with his newfound energy. He gets around 8 hours of sleep nightly. His appetite has increased. Last year, he had two epis...
A: Continue paroxetine therapy for 2 years
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Q:A 15-year-old girl comes to the physician because of a 2-year history of irregular menstrual bleeding. Menses have occurred at irregular 45- to 60-day intervals since menarche at the age of 13 years. Her last menstrual period was 5 weeks ago and lasted for 7 days with heavy flow and no cramping. She is not sexually a...
D: Anovulation
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Q:A 7-year-old boy is brought by his parents to his pediatrician due to progressive fatigue and shortness of breath while playing sports. He is otherwise healthy with no known medical disorders and no other symptoms. The boy was born at 39 weeks gestation via spontaneous vaginal delivery. He is up to date on all vaccin...
D: Atrial septal defect
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Q:A previously healthy 17-year-old boy is brought to the emergency department by his mother for further evaluation after elective removal of his wisdom teeth. During the procedure, the patient had persistent bleeding from the teeth's surrounding gums. Multiple gauze packs were applied with minimal effect. The patient h...
D: Hemophilia
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Q:A 48-year-old man with a history of diabetes mellitus presents to his primary care physician with lethargy, joint pain, and impotence. Lab evaluation is notable for a ferritin of 1400 ug/L (nl <300 ug/L), increased total iron, increased transferrin saturation, and decreased total iron binding capacity. All of the fol...
C: It may improve with calcium chelators
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Q:A 68-year-old man is brought to the clinic by his daughter who has noticed behavioral changes and frequent headaches for the past 2 weeks. The patient’s daughter says he has been having memory and simple calculation issues, gets upset easily, and his grip strength has dramatically declined. The patient was completely...
B: Tearing of bridging veins
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Q:A 30-year-old woman, gravida 1, para 0, at 40 weeks' gestation is admitted to the hospital in active labor. Pregnancy was complicated by iron deficiency anemia treated with iron supplements. At the beginning of the first stage of labor, there are coordinated, regular, rhythmic contractions of high intensity that occu...
D: Observation for another hour
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Q:A 23-year-old woman, gravida 2, para 1, at 26 weeks gestation comes to the physician for a routine prenatal visit. Physical examination shows a uterus consistent in size with a 26-week gestation. Fetal ultrasonography shows a male fetus with a thick band constricting the right lower arm; the limb distal to the constr...
C: Disruption
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Q:A 47-year-old man presents to the emergency department due to a rash. He states the rash started last night and is very concerning to him. The patient cannot remember being exposed to any environmental stimuli such as new detergents or poison ivy. The patient recently started following with a primary care provider wh...
D: Steven-Johnson syndrome
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Q:A 12-year-old boy presents to the pediatrician with complaints of chronic cough for the past two years. The cough is present during the day, especially after returning from school. His school teacher says he does not cough at school. The cough is absent while he is asleep, although it increases during examinations or...
D: Haloperidol
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Q:A 27-year-old woman consults an obstetrician as she is planning to become pregnant. She has been diagnosed with HIV (human immunodeficiency virus) infection recently and is currently taking antiretroviral therapy (HAART), as prescribed by her physician. The obstetrician emphasizes the importance of antenatal and peri...
B: Efavirenz and Delavirdine
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Q:A 1-month-old baby is brought to the emergency department because he had a coughing spell while feeding and turned blue. The mother says that the blue color went away when she picked the baby up and brought his knees to his chest. The physician orders a chest X-ray which shows a boot-shaped heart and he tells the mot...
E: Pulmonary stenosis, right ventricular hypertrophy, ventricular septal defect, overriding aorta
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Q:A 16-year-old girl is brought to the physician by her mother because she has not had her menstrual period yet. At birth, she was found to have partial labial fusion and clitoromegaly. The mother reports that during the pregnancy she had noticed abnormal hair growth on her chin. The girl has severe acne. Three years a...
E: Aromatase deficiency
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Q:A 6-month-old infant is brought to the physician’s office by his parents due to a fever, cough, and shortness of breath. The cough is dry and has been progressively worsening for the past 48 hours along with the shortness of breath. His fever never exceeded 37.8°C (100.0°F) at home. The parents say that he has also h...
D: Bronchiolitis
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Q:A 67-year-old woman comes to the physician because of fever, chills, myalgias, and joint pain 1 month after undergoing aortic prosthetic valve replacement due to high-grade aortic stenosis. She does not drink alcohol or use illicit drugs. Her temperature is 39.3°C (102.8°F). She appears weak and lethargic. Physical e...
B: Novobiocin-sensitive, coagulase-negative cocci
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Q:A 42-year-old woman presents to her primary care provider with vision loss. She reports that twice over the last 2 weeks she has had sudden “black out” of the vision in her right eye. She notes that both episodes were painless and self-resolved over approximately a minute. The patient’s past medical history is signif...
E: Ultrasound of the carotid arteries
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Q:A 37-year-old man presents to his primary care provider with dysphagia. He notes that his symptoms began several weeks ago and have worsened over time. He now has trouble swallowing solids and liquids. He denies any other symptoms. He has no significant past medical history. Travel history reveals a recent trip to So...
A: Barium swallow
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Q:A 61-year-old woman presents for a routine health visit. She complains of generalized fatigue and lethargy on most days of the week for the past 4 months. She has no significant past medical history and is not taking any medications. She denies any history of smoking or recreational drug use but states that she drink...
B: Continue oral ferrous sulfate and supplement with ascorbic acid
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Q:A 41-year-old man with HIV comes to the physician because of rectal bleeding and itching for 2 weeks. During this period, he has also had pain with defecation. Four months ago, he was diagnosed with anogenital warts that were treated with cryotherapy. Over the past year, he has been sexually active with 3 male partne...
E: Inactivation of TP53 gene "
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Q:A 3-year-old child is brought to the emergency department by his parents. The child presents with significant rapid breathing and appears unwell. On examination, his liver size is 1.5 times larger than children of his age, and he has mild pitting edema in his legs. This child is also in the lower weight-age and heigh...
B: Atrial septal defect
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Q:A neurophysiologist describes the mechanism of a specific type of synaptic transmission to his students. While illustrating this, he points out that when the action potential reaches the presynaptic terminal of a chemical synapse, the voltage-gated Ca2+ channels open. Ca2+ ions trigger the release of neurotransmitter...
B: Epinephrine
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Q:A 32-year-old man with a history of major depressive disorder is brought to the emergency department by his wife because of a sudden onset of restlessness and disorientation that developed 3 hours ago. The patient’s wife says that he suddenly started sweating, having tremors, and mumbling to himself. Yesterday, the p...
C: Sertraline
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Q:A 55-year-old woman comes to your office because she noticed the growth of unwanted hair on her upper lip, chin, and chest. She has also noticed an increase in blackheads and pimples on her skin. Her female partner has also recently brought to her attention the deepening of her voice, weight gain, and changes in her ...
B: Sertoli-Leydig cell tumour
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Q:A 44-year-old female presents to her primary care physician with complaints of headache, fatigue, muscle weakness, and frequent urination. These issues have developed and worsened over the past month. She has no significant prior medical or surgical history other than cholecystitis managed with cholecystectomy 5 year...
E: Metabolic alkalosis, hypernatremia, hypokalemia
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Q:A 58-year-old woman comes to the physician because of a 6-month history of difficulty walking, clumsiness of her arms and legs, and slurred speech. Physical examination shows masked facies and a slow, shuffling gait. When her ankles are passively flexed, there is involuntary, jerky resistance. Treatment is initiated ...
B: Orthostatic hypotension
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Q:A 12-month-old boy is brought to the pediatrician for a routine examination. Past medical history is significant for a pyloric myomectomy at 2 months of age after a few episodes of projectile vomiting. He has reached all appropriate developmental milestones. He currently lives with his parents and pet cat in a house ...
D: Decreased hemoglobin
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Q:A 47-year-old woman presents to a local medical shelter while on a mission trip with her church to help rebuild homes after a hurricane. She has been experiencing severe nausea, vomiting, and diarrhea for the last 2 days and was feeling too fatigued to walk this morning. On presentation, her temperature is 99.2°F (37...
D: Increased adenylyl cyclase activity
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Q:A 48-year-old woman with alpha-1-antitrypsin deficiency undergoes a lung transplant. She tolerates the surgery well, but 3 years later develops inflammation and fibrosis in her terminal bronchioles. Which of the following best describes the pathophysiology of this patient's deterioration?? {'A': 'Staphylocuccus aureu...
C: Lymphocytic inflammation of the bronchiolar wall
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Q:A 8-month-old girl is brought to her pediatrician because her mom is concerned that she may have a "lazy eye". She was born prematurely at 33 weeks and was 3 pounds at birth. Her mother also says that there is a history of visual problems that run in the family, which is why she wanted to make sure that her daughter ...
A: Asymmetric corneal light reflex
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Q:A 13-year-old teenage girl was brought to the emergency department by her mom after she collapsed. Her mom reports that she was at a birthday party when all of a sudden she fell. She reported left foot weakness and has been limping ever since. The patient has been healthy and had an uncomplicated birth history, thoug...
B: Conversion disorder
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Q:A 30-year-old woman presents to her family doctor requesting sleeping pills. She is a graduate student and confesses that she is a “worry-a-holic,” which has been getting worse for the last 6 months as the due date for her final paper is approaching. During this time, she feels more on edge, irritable, and is having ...
A: Buspirone
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Q:A 25-year-old woman presents to the emergency department with nausea and vomiting. She denies any recent illnesses, sick contacts, or consumption of foods outside of her usual diet. She reports smoking marijuana at least three times a day. Her temperature is 97.7°F (36.5°C), blood pressure is 90/74 mmHg, pulse is 100...
C: Administer ondansetron and isotonic saline with potassium
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Q:A 34-year-old male is brought to the emergency department by fire and rescue following a motor vehicle accident in which the patient was an unrestrained driver. The paramedics report that the patient was struck from behind by a drunk driver. He was mentating well at the scene but complained of pain in his abdomen. Th...
B: Decreased pulmonary capillary wedge pressure
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Q:A 26-year-old Caucasian G1 presents at 35 weeks gestation with mild vaginal bleeding. She reports no abdominal pain or uterine contractions. She received no prenatal care after 20 weeks gestation because she was traveling. Prior to the current pregnancy, she used oral contraception. At 22 years of age she underwent a...
D: Smoking
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Q:A 7-year-old girl is brought to the physician by her father because of a dry cough, nasal congestion, and intermittent wheezing during the past 2 months. Since birth, she has had four upper respiratory tract infections that resolved without treatment and one episode of acute otitis media treated with antibiotics. She...
E: Spirometry
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Q:A 42-year-old man comes to the physician for 1 month of worsening right knee pain. He has not had any trauma other than stubbing his toe 3 days ago at the garage where he works as a mechanic. Examination of the right knee shows swelling and erythema with fluctuance over the inferior patella. There is tenderness on pa...
E: Inflammation of periarticular fluid-filled sac
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Q:A 17-year-old man presents to his primary care physician with a bilateral tremor of the hands. He is a senior in high school and during the year, his grades have plummeted to the point that he is failing. He says his memory is now poor, and he has trouble focusing on tasks. His behavior has changed in the past 6 mont...
A: Mineral accumulation in the basal ganglia
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Q:A 4-year-old boy presents to the emergency department with a 1 hour history of severe knee pain after he bumped his knee against a door. He has no past medical history though his parents say that he seems to bruise fairly easily. His parents say that they are afraid he may have accidentally taken his grandfather's wa...
D: Production of an autoantibody
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Q:A 40-year-old man comes to the physician for a follow-up examination. He feels well. He has no urinary urgency, increased frequency, dysuria, or gross hematuria. He has a history of recurrent urinary tract infections. His last urinary tract infection was 3 months ago and was treated with ciprofloxacin. Current medica...
E: CT urography "
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Q:A 40-year-old man presents with severe fatigue, dyspnea on exertion, and weight loss. He reports a weight loss of 15 kg (33.0 lb) over the past 3 months and feels full almost immediately after starting to eat, often feeling nauseous and occasionally vomiting. Past medical history is not significant. However, the pati...
A: Ligament of Treitz
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Q:A 33-year-old man with a history of alcohol abuse and cirrhosis presents to the emergency department with profuse vomiting. The patient is aggressive, combative, emotionally labile, and has to be chemically restrained. The patient continues to vomit and blood is noted in the vomitus. His temperature is 99.2°F (37.3°C...
E: Transmural tear
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Q:A 74-year-old male is brought to the emergency department 1 hour after he fell from the top of the staircase at home. He reports pain in his neck as well as weakness of his upper extremities. He is alert and immobilized in a cervical collar. He has hypertension treated with hydrochlorthiazide. His pulse is 90/min and...
E: MRI of the cervical spine without contrast
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Q:A 36-year old pregnant woman (gravida 4, para 1) presents at week 11 of pregnancy. Currently, she has no complaints. She had an uncomplicated 1st pregnancy that ended in an uncomplicated vaginal delivery at the age of 28 years. Her male child was born healthy, with normal physical and psychological development over t...
C: Recommend chorionic villus sampling with subsequent cell culturing and karyotyping
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Q:A 63-year-old man is brought to the emergency department by the police after he was found in the streets lying unconscious on the ground. Both of his pupils are normal in size and reactive to light. There are no obvious signs of head trauma. The finger prick test shows a blood glucose level of 20 mg/dL. He has been b...
D: Macrocytosis MCV > 100fL
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Q:A 65-year-old man comes to his primary care physician with a 6-month history of bilateral calf pain. The pain usually occurs after walking his dog a few blocks and is more severe on the right side. He has coronary artery disease, essential hypertension, and type 2 diabetes mellitus. He has smoked two packs of cigaret...
A: Graded exercise therapy
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Q:A previously healthy 25-year-old man comes to the physician because of a 1-week history of fever and fluid release from painful lumps in his right groin. He had an atraumatic ulceration of his penis about 1 month ago that was not painful and resolved on its own within 1 week. He works at an animal shelter for abandon...
C: Chlamydia trachomatis
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Q:A 67-year-old man comes to the physician because of numbness and burning sensation of his legs for the past week. He also complains that his stools have been larger and rougher than usual. He has non-Hodgkin lymphoma and is currently receiving chemotherapy with prednisone, vincristine, rituximab, cyclophosphamide, an...
A: Adverse effect of vincristine
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Q:A 76-year-old Japanese man is admitted to the hospital because of a 3-month history of loose stools and worsening peripheral edema. He also reports fatigue, a 10-pound weight loss over the past 6 weeks, and a tingling sensation in his hands and feet over the same time period. Aside from the family dog, he has not had...
C: Bacterial overgrowth
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Q:A 7-week-old male presents to the pediatrician for vomiting. His parents report that three weeks ago the patient began vomiting after meals. They say that the vomitus appears to be normal stomach contents without streaks of red or green. His parents have already tried repositioning him during mealtimes and switching ...
B: Intravenous hydration
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Q:An investigator is studying nutritional deficiencies in humans. A group of healthy volunteers are started on a diet deficient in pantothenic acid. After 4 weeks, several of the volunteers develop irritability, abdominal cramps, and burning paresthesias of their feet. These symptoms are fully reversed after reintroduc...
E: Alpha-ketoglutarate dehydrogenase
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Q:A 64-year-old man presents to his primary care physician's office for a routine check-up. His past medical history is significant for type 2 diabetes mellitus, hypertension, chronic atrial fibrillation, and ischemic cardiomyopathy. On his last visit three months ago, he was found to have hyperkalemia, at which time l...
D: Renal tubular acidosis
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Q:A 17-year-old boy comes to the physician because of a 3-month history of pain in his right shoulder. He reports that he has stopped playing for his high school football team because of persistent difficulty lifting his right arm. Physical examination shows impaired active abduction of the right arm from 0 to 15 degre...
A: Suprascapular nerve
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Q:A 72-year-old man is brought to the physician by his son because of gradually progressive yellow discoloration of his skin and generalized pruritus for the past 2 weeks. During this period, his appetite has decreased and he has had a 6.3-kg (14-lb) weight loss. He reports that his stool appears pale and his urine is ...
A: Pancreatic adenocarcinoma
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Q:A 2-day-old infant dies of severe respiratory distress following a gestation complicated by persistent oligohydramnios. Upon examination at autopsy, the left kidney is noted to selectively lack cortical and medullary collecting ducts. From which of the following embryological structures do the cortical and medullary ...
E: Ureteric bud
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Q:A 2-year-old child is brought to the emergency department with rapid breathing and a severe cyanotic appearance of his lips, fingers, and toes. He is known to have occasional episodes of mild cyanosis, especially when he is extremely agitated. This is the worst episode of this child’s life, according to his parents. ...
B: Boot-shaped heart