task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1cc(-c2ccc(F)cc2)nc2cc(-c3ccccc3)nn12 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? Cc1ccc(C)c(NC(=O)CSc2cc(-c3ccccn3)nc(C)n2)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCCOc1cccc(NC(=O)Nc2ccc(C)cc2C)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ester group? CCNS(=O)(=O)[C@H]1CCN(C(=O)c2cc(C)cc(O)c2)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a phenol group? CCOC[C@@H]1CCCN(C(=O)NC[C@@H](OC)c2ccc(F)cc2)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [5*]N1CCCC1 ### Response: O=C(CCn1cnc2ccccc2c1=O)Nc1ccc(S(=O)(=O)N2CCCC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNS(=O)(=O)c1ccc(Br)c(C(=O)Nc2ccc3nc(N4CCCC4)sc3c2)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nsc(NC2CCC(NS(C)(=O)=O)CC2)n1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccc([N+](=O)[O-])cc1)Nc1cn[nH]c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[C@H]1COCCN1C(=O)c1cccc(OCC(N)=O)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(=O)N[C@H]1CCC[C@H](S(C)(=O)=O)C1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1COCCN1c1ccc(cc1NC(=O)NCC1(CC)CC1)Cl ### Response: CCC1(CNC(=O)Nc2cc(Cl)ccc2N2CCOCC2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N(C(c1c(cc(cc1)NC(N1CCCC1(C)C)=O)Cl)=O)CC)C ### Response: CCN(CC)C(=O)c1ccc(NC(=O)N2CCCC2(C)C)cc1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc2[nH]c3c(c2c1)C[C@H](C)CC3 Fragment 2: [5*]Nc1ccccc1 ### Response: C[C@@H]1CCc2[nH]c3ccc(C(=O)Nc4ccccc4)cc3c2C1
functional_group
### Instruction: Does the molecule contain a amide group? CO[C@]1(C)C[C@H](NC(=O)N2CCOC[C@@H]2C2CC2)C1(C)C ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COc1ccc(S(=O)(=O)N(C)CC(=O)N2CCOCC2)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cn2cccnc2n1 Fragment 2: [5*]Nc1c(F)cc(C#C)cc1F ### Response: C#Cc1cc(F)c(NC(=O)c2cn3cccnc3n2)c(F)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CN(c2nc3ccc(CC)cc3cc2C#N)CC[NH2+]1 ### Response: CCc1ccc2nc(N3CC[NH2+]CC3)c(C#N)cc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(c1ccc(cc1)C)(N(c1c(ccc(c1)Cl)OC)CC(NN=C1CCN(C)CC1)=O)=O ### Response: COc1ccc(Cl)cc1N(CC(=O)NN=C1CCN(C)CC1)S(=O)(=O)c1ccc(C)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCn1c(S)nnc1-c1ccc(C)c(C)c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C#C)NCC(N[C@@H]1CCC[C@H]1C)=O ### Response: C#CCNCC(=O)N[C@@H]1CCC[C@H]1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH2+][C@@H](CC)c1ccn(Cc2cncn2C)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](NC(=O)Nc1ccc(F)c(C(N)=O)c1)c1cc(F)ccc1F ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([S@@](=O)C(C)C)cc1 Fragment 2: [9*]n1cccn1 ### Response: CC(C)[S@](=O)c1ccc(C(=O)NCc2cccnc2-n2cccn2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](c1cccc(c1)[N+]([O-])=O)(N(C(c1ccc(CNC(=O)C)cc1)=O)C)C ### Response: CC(=O)NCc1ccc(C(=O)N(C)[C@H](C)c2cccc([N+](=O)[O-])c2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NCC(=O)N[C@@](C#N)(C)C(C)C)ccc(c1F)C(N)=O ### Response: CC(C)[C@@](C)(C#N)NC(=O)CNc1ccc(C(N)=O)c(F)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C(=O)N2CC[C@@]3(C2)C(=O)Nc2ccc(OC)cc23)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1c2ccccc2N(C)CC[C@@H]1C Fragment 2: [1*]C(=O)c1occc1Br ### Response: C[C@H]1CCN(C)c2ccccc2N1C(=O)c1occc1Br
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NCCc1c([nH]c2c1cccc2)C)N(Cc1nnc(n1C)C1CC1)C ### Response: Cc1[nH]c2ccccc2c1CCNC(=O)N(C)Cc1nnc(C2CC2)n1C
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C1Nc2cc(N(C3CC3)C)c(cc2[C@H]1O)Cl ### Response: CN(c1cc2c(cc1Cl)[C@@H](O)C(=O)N2)C1CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1CCCCN1C[NH+]1CC[C@@H](CSc2ccccc2)C1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nnc(NC(=O)[C@H]2CC(=O)C(OCc3ccccc3)=CO2)s1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccn(C)n1 Fragment 2: [4*][C@@H](C)c1ccc([16*])cc1 ### Response: C[C@H](N[C@@H]1CCCN(c2ccn(C)n2)C1=O)c1ccc(-n2ccnc2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cc(C)cc(C)c1 Fragment 2: [11*]SCc1cc(=O)n2ccccc2n1 ### Response: Cc1cc(C)cc(CSCc2cc(=O)n3ccccc3n2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(cc(c1)S(/N=C(\[O-])c1c(cccc1)COC)(=O)=O)CCC2 ### Response: COCc1ccccc1/C([O-])=N/S(=O)(=O)c1ccc2c(c1)CCC2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=C(C)C[NH+](CC)[C@H]1CCc2c(c(C(=O)NCc3ccncc3)nn2C)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(-c2ccc(cc2)Cl)coc2cc(OCC(N[C@H](c3ccccc3)CO)=O)ccc12)=O ### Response: O=C(COc1ccc2c(=O)c(-c3ccc(Cl)cc3)coc2c1)N[C@@H](CO)c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. COc1cc(NC([C@@H]2CCCN(C(C3C=C[C@@H]4N=CC=C4C=3)=O)C2)=O)cc(c1)OC ### Response: COc1cc(NC(=O)[C@@H]2CCCN(C(=O)C3=CC4=CC=N[C@H]4C=C3)C2)cc(OC)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(CNC(=O)NCC[NH+](C(C)C)C(C)C)cc1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)NC(=O)c1ccc(NCC(=O)NCc2ccccc2F)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(NC(=O)c2n[nH]c(C(C)C)n2)cc1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@@H]1C[C@H](O)CN1Cc1ccc([S@@](C)=O)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc2c(Cn3nc4ccccn4c3=O)cc(=O)oc2c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? CC[C@H]1CC[C@H](NC(=O)c2cc(C)c(C#CCN)s2)[C@@H]1C ### Response: No
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(Cn1cnc2c(oc3ccccc32)c1=O)N1CCC[C@@H]2CCCC[C@H]21 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1ccc(cc1OC)/C=C1/C(=O)N(C(S1)=S)c1ccccc1)CC(=O)Nc1ccc(F)cc1 ### Response: COc1cc(/C=C2\SC(=S)N(c3ccccc3)C2=O)ccc1OCC(=O)Nc1ccc(F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCc1ccccc1OCC1CC1)N[C@H]1C[C@H]2CC[C@@H]1O2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(CNC(=O)N[C@H](C[NH+]1CCCC1)c1ccccc1)Nc1ccccc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? COC[C@@](C)(O)CNC(=O)C(=O)NCC(C)C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(N)c1csc(CN2CC[C@H](C2)S(=O)(NC(C)C)=O)c1 ### Response: CC(C)NS(=O)(=O)[C@@H]1CCN(Cc2cc(C(N)=O)cs2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(Oc1nccc(CNC(Nc2ccc(-c3nnc(C)o3)cc2)=O)c1)(C)C ### Response: Cc1nnc(-c2ccc(NC(=O)NCc3ccnc(OC(C)(C)C)c3)cc2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@@H](CC)C(C)=O Fragment 2: [15*][C@@H]1CCO[C@]2(CCSC2)C1 ### Response: CC[C@@H](C(C)=O)[C@@H]1CCO[C@]2(CCSC2)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC/[NH+]=C(/NC[C@H]1CCC[C@H]1O)NC(C)(C)C ### Response: 0
functional_group
### Instruction: Does the molecule contain a halide group? CCOC(=O)C1(C#N)CC(OC)(OC)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1nccn1-c1ccc(N2CCN(C(=O)Cn3cnc4ccccc4c3=O)CC2)nn1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Cn2c(NC([C@@H]3COc4ccccc4O3)=O)ccn2)ccc(c1)Cl ### Response: O=C(Nc1ccnn1Cc1ccc(Cl)cc1)[C@@H]1COc2ccccc2O1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(CC)S(=O)(=O)c1ccc(CNC(=O)c2c(C)cccc2C)cc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(OCC(=O)N/N=C(/C)C(=O)[O-])cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? C[C@@H]1CN(CC2(CS)CCCC2)CC[NH+]1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2nn(C[NH+]3CCC(c4nc5ccccc5o4)CC3)c(=S)n2C)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCCC1 Fragment 2: [4*]CC(=O)N/N=C\c1cccc2c1OCCO2 ### Response: O=C(C[NH+]1CCCCC1)N/N=C\c1cccc2c1OCCO2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H](NS(C)(=O)=O)C(=O)N[C@H]1CCCC[C@@H]1Cc1ccccc1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(C(=O)[C@H]1[C@H](C=C(C)C)C1(C)C)[C@H]1CCS(=O)(=O)C1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a carboxyl group? CC(=O)Nc1cccc(NC(=O)CSc2nnnn2-c2cc(C)ccc2C)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1cc(F)ccc1F)c1ccc(-n2cccn2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCNC(=O)Nc1ccccc1C(C)C ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? COC(=O)[C@](O)(c1cc(C)c(O)c(Cl)c1)C(F)(F)F ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccoc1CN1C(c2c(cccc2)N[C@H]1SCC(N[C@H]1N=NC(=C1)C)=O)=O ### Response: CC1=C[C@@H](NC(=O)CS[C@@H]2Nc3ccccc3C(=O)N2Cc2ccco2)N=N1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@H](C(=O)N[C@H]1CCCN(Cc2ccccc2)C1=O)[NH+](C)C ### Response: 5
canonicalization
### Instruction: Canonicalize the following SMILES string. n1nn(cc1C(N[C@H](C)c1cccc(c1C)C)=O)CC(=O)N ### Response: Cc1cccc([C@@H](C)NC(=O)c2cn(CC(N)=O)nn2)c1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC[C@H](O)C[NH2+][C@@H](c1ccc(Cl)c(Cl)c1)C1CC1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(cc(c1)C)NC(=O)Cn1nc(c2cnccc12)C(F)(F)F)C ### Response: Cc1ccc(C)c(NC(=O)Cn2nc(C(F)(F)F)c3cnccc32)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCN(Cc2sc3C[C@H](C)CCc3n2)C[C@H]1C(NC)=O ### Response: CNC(=O)[C@H]1CCCN(Cc2nc3c(s2)C[C@H](C)CC3)C1
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1ccc(NC(=O)C[C@@H]2C(=O)OCCN2Cc2ccccc2)cc1[N+](=O)[O-] ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)OC(=O)N1[C@@H]2CC[C@H]1CC([NH2+]C1COC1)C2 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)[C@H]1CCC[NH+](C/C=C/Cl)CC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1nc2c(Cl)c(Cl)ccc2s1)c1ccccc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C(C)c1cccc(OC)c1 Fragment 2: [9*]n1ccccc1=O ### Response: COc1cccc(/C(C)=C/C(=O)OCCn2ccccc2=O)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(N[5*])cc1 Fragment 2: [3*]OCC ### Response: CCOC(=O)c1ccc(NC(=O)C[C@H]2CSc3nc(CC)cc(=O)n32)cc1
functional_group
### Instruction: Does the molecule contain a amine group? COc1ccc(-n2nc(C)c3c2N=C(O)C[C@H]3c2ccccc2OCC(C)C)nn1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nn(C)cc1CN1CCN(C(=O)[C@@H]2C[C@@H]2C)CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1cnc2c(cnn2-c2ccc(F)cc2)c1=O)NCc1ccc(Cl)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? Clc1ccc(C2([NH2+]C3CCCC3)CCOCC2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(S(=O)(=O)N2CCOCC2)cc1C(=O)N(Cc1cccs1)C[C@@H]1CCCO1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(Cl)cc1Cl Fragment 2: [15*][C@@H]1C(=O)C2=C(C[C@H]1C)NC(=O)C[C@@H]2[15*] ### Response: COC(=O)[C@@H]1C(=O)C2=C(C[C@H]1C)NC(=O)C[C@@H]2c1ccc(Cl)cc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ccccc2CCN(C(CN2c3ccccc3S[C@H](C2)C)=O)C1 ### Response: C[C@H]1CN(CC(=O)N2CCc3ccccc3C2)c2ccccc2S1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(c1cccc(c1)N1C(=O)[C@@H]2[C@@H](C1=O)[C@@H]1C=C[C@H]2C1)OCC(c1cc([N+](=O)[O-])c(C)cc1)=O ### Response: Cc1ccc(C(=O)COC(=O)c2cccc(N3C(=O)[C@@H]4[C@@H](C3=O)[C@H]3C=C[C@@H]4C3)c2)cc1[N+](=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(C)NC(=O)N1CC[C@@]2(C1)C(=O)Nc1ccccc12 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ncccc1CNC(=O)Nc1cccc(CC)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(N2CCN(C(=O)[C@@H](c3ccccc3)n3cccc3)CC2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc([C@H]2[C@@H]3[C@H](c4cc(S(=O)(NCCC)=O)ccc4N2)C=CC3)cc1)[N+](=O)[O-] ### Response: CCCNS(=O)(=O)c1ccc2c(c1)[C@@H]1C=CC[C@@H]1[C@H](c1ccc([N+](=O)[O-])cc1)N2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1cc(Cl)c2c(c1)OCCCO2 Fragment 2: [1*]C(=O)N1CCCC[C@@H]1C ### Response: C[C@H]1CCCCN1C(=O)NCc1cc(Cl)c2c(c1)OCCCO2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccn1[9*] Fragment 2: [8*]CC(=O)[O-] ### Response: CN(C(=O)c1cccn1CC(=O)[O-])c1ccc(F)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1([NH3+])C[C@@H](CCC1)OCCCCC#N ### Response: N#CCCCCO[C@@H]1CCC[C@H]([NH3+])C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C(CC)CC Fragment 2: [4*][C@@H](CC)CC[NH3+] ### Response: CCC(CC)[NH+]1CCCN([C@@H](CC)CC[NH3+])CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[NH+](Cc2noc(C3CC3)n2)[C@@H](c2c(c(ccc2)C)C)CC1 ### Response: Cc1cccc([C@H]2CCCC[NH+]2Cc2noc(C3CC3)n2)c1C
functional_group
### Instruction: Does the molecule contain a amide group? CCC[C@@H]1CN(C(=O)Cc2ccc(NC(C)=O)cc2)CCO1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CSc1nnc(Cc2cccs2)n1C1CC1)Nc1ccc2c(c1)CCC2 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)C[C@@H]1CCCN(C(=O)Nc2c[nH]nc2-c2ccccn2)C1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1c(/N=C/c2cc([N+](=O)[O-])ccc2Cl)sc2c1CCC2 ### Response: 1