task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1ccc(C)cc1Br Fragment 2: [16*]c1ccccc1 ### Response: Cc1ccc(S(=O)(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)c(Br)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(CO)cc1 Fragment 2: [5*]Nc1cc(C)ccc1F ### Response: Cc1ccc(F)c(NC(=O)c2ccc(CO)cc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CN([C@@H](C)C(=O)Nc2ccc(I)cc2)C[C@H](C)O1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(COc2ccc(/C=C3/C(=O)NC(S3)=N)cc2Cl)cc1 ### Response: N=C1NC(=O)/C(=C/c2ccc(OCc3ccccc3)c(Cl)c2)S1
functional_group
### Instruction: Does the molecule contain a aldehyde group? CC(C)Oc1ccc(C(=O)OCc2nc(C3CC3)cs2)cn1 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? CCN(C[C@@H](C)/C(N)=N/O)C(=O)C1(C)CCCC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(c1nnc(N[C@H](C(C)C)COC)cc1)N(C)C ### Response: COC[C@H](Nc1ccc(C(=O)N(C)C)nn1)C(C)C
functional_group
### Instruction: Does the molecule contain a amide group? CC1(C)CCN([C@@H](C[NH3+])c2cc(Br)c3c(c2)OCO3)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN1C[C@H](CN(C)c2ccc(C(N)=O)cc2[N+](=O)[O-])Oc2ccccc21 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cccc(C)c1NC(=O)[C@H](C)N1CCN(c2ccc(Cl)cn2)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc(C=O)c(C)n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=c1[nH]c2ccccc2c(=O)n1Cc1ccnc(OCC(F)(F)F)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? CCOc1cc(/C=C2/C(=O)N(c3ccccc3)N=C2C)ccc1OC(=O)c1cccs1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(F)(F)F Fragment 2: [16*]c1cc(NN)ccc1F ### Response: NNc1ccc(F)c(C(F)(F)F)c1
functional_group
### Instruction: Does the molecule contain a amine group? COc1ccc(C[C@@H](C)C[NH2+][C@H](C)c2cncc(F)c2)cc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](O)Cn1c(C(C)(C)C)nc2cc(Cl)ccc21 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CCC#N)C(=O)Nc1ccccc1CN1C[C@@H](C)O[C@@H](C)C1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(N(C[C@H]2C=c3ccc(C)cc3=[NH+]C2=O)C(=O)C(C)C)c(C)c1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nnc(NC(=O)[C@H]2CC(=O)N(c3ccc(F)cc3)C2)s1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. CCC(Nc1ccc(c(NC(/C=C/c2ccc(cc2)C(=O)NC)=O)c1)Cl)=O ### Response: CCC(=O)Nc1ccc(Cl)c(NC(=O)/C=C/c2ccc(C(=O)NC)cc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccc(S(=O)(=O)N2CCCC2)cc1Cl)C1=COCCO1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. COC(=O)c1c(ccc(Cl)c1)OC(c1cccc([N+](=O)[O-])c1)=O ### Response: COC(=O)c1cc(Cl)ccc1OC(=O)c1cccc([N+](=O)[O-])c1
canonicalization
### Instruction: Canonicalize the following SMILES string. [nH]1ccnc1[C@@H]1[NH2+]CCCC1 ### Response: c1c[nH]c([C@H]2CCCC[NH2+]2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](C)(C(NCc1ccccc1)=O)Sc1cc(C)ccc1C ### Response: Cc1ccc(C)c(S[C@H](C)C(=O)NCc2ccccc2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccccc1C Fragment 2: [16*]c1ccccc1C ### Response: Cc1ccccc1Nc1nc(N)nc(C[NH+]2CCC(Cc3ccccc3)CC2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CCC2(CC1)OC[C@H](C)O2)Cc1sc2ccccc2c1 ### Response: C[C@H]1COC2(CCN(Cc3cc4ccccc4s3)CC2)O1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(C)(C)OC(=O)Nc1ccc(-c2cc(O)cc(C(F)(F)F)c2)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? O=C(N1CCC(C(=O)[O-])(n2cc[nH+]c2)CC1)C1(c2ccccc2)CC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? Cc1c(C(=O)N2CCOC[C@H]2CC(C)C)cnn1-c1ccncc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1nc2c(s1)CN(CC(=O)Nc1ccc(C(C)=O)cc1)CC2 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1CC[NH+]2CCCC[C@H]12 Fragment 2: [1*]C(=O)C[8*] ### Response: CCn1c(=O)n(CC(=O)N[C@@H]2CC[NH+]3CCCC[C@H]23)c2ccccc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)[C@@H](c1ccc(Cl)cc1)N1CCN(C(=O)[C@]2(C)CC2(Cl)Cl)CC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [8*]Cc1ccco1 ### Response: O=C1c2oc3ccccc3c(=O)c2[C@H](c2ccc(F)cc2)N1Cc1ccco1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)CN(Cc1cc(C(N)=O)cs1)C1CCOCC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(OC)c(/C=C2/SC(=S)N(Cc3ccco3)C2=O)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [5*]NS(=O)(=O)c1cc(C)c(OC)c(C)c1 ### Response: COc1c(C)cc(S(=O)(=O)NCC[C@@H](O)c2cccs2)cc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NC1CC1)c1nc(-c2cn(-c3ccc(Cl)cc3)nn2)no1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? O=C1CS[C@@H](c2cccs2)N1Cc1cccnc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC[C@@H]1[13*] Fragment 2: [1*]C(=O)c1cc(OC)cc(Br)c1OC ### Response: COc1cc(Br)c(OC)c(C(=O)N2CCC[C@@H]2C(=O)[O-])c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)Cn1nc(C(=O)NCc2cccnc2)c2c1CC[NH+](Cc1cn(C)c3ccccc13)C2 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1=c2ccccc2=[NH+][C@@H]1CN(C)C[C@@H]1C=N[C@H](S(C)(=O)=O)N1C[C@@H]1CCCO1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? CO[C@@H]1CCCC[C@H]1NC(=O)N(C)CCN1CCN(c2ccccc2)CC1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]([NH2+]Cc1nc(Cc2ccccc2)no1)[C@@H](C)n1cccn1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(S(=O)(=O)NC(=O)n2cc(-c3ccnc4ccccc34)c(-c3ccccn3)n2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1[16*] Fragment 2: [1*]C(=O)N1CC[C@H]([15*])C1 ### Response: CC(C)CCO[C@H]1CCN(C(=O)Nc2ccccc2-n2cccn2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1([C@@H](C)CNC(=O)CC2CCC(CC2)OC)nc(no1)-c1ccccc1 ### Response: COC1CCC(CC(=O)NC[C@H](C)c2nc(-c3ccccc3)no2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CC[C@@H]1CCCN(C(=O)C2CCOCC2)C1)NCc1ccccc1F ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(nc(c(C(=O)OC)c([nH]1)C)SCc1ccccc1Br)=O ### Response: COC(=O)c1c(SCc2ccccc2Br)nc(=O)[nH]c1C
canonicalization
### Instruction: Canonicalize the following SMILES string. C1O[C@H](CN(C1)C(=O)CNCc1ccccc1)C(F)(F)F ### Response: O=C(CNCc1ccccc1)N1CCO[C@@H](C(F)(F)F)C1
functional_group
### Instruction: Does the molecule contain a ketone group? COc1nc(C(=O)N(CCC(F)(F)F)C2CCCC2)cc2ccccc12 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=[N+](c1cc(c(OCC(NCC2CC2)=O)cc1)Br)[O-] ### Response: O=C(COc1ccc([N+](=O)[O-])cc1Br)NCC1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccoc1 Fragment 2: [5*][NH+]1CC[C@]2(CCOC2)C1 ### Response: c1cc(C[NH+]2CC[C@]3(CCOC3)C2)co1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(C#N)c1)[C@@H](S[C@@H](C)c1oc(C(C)(C)C)cn1)C ### Response: C[C@H](S[C@@H](C)c1ncc(C(C)(C)C)o1)c1ccc(C#N)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC[C@H]1COc2ccccc21)c1cccc(Cl)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(C)c(Cl)cc1OC Fragment 2: [1*]C(=O)C[4*] ### Response: COc1cc(Cl)c(C)cc1NCC(=O)Nc1cc(OC)c([N+](=O)[O-])cc1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C(=O)NC[C@@H]2CC(=O)N(Cc3ccccc3)C2)cc1[N+](=O)[O-] ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Cc1cn(Cc2ccccc2)c2ccccc12)N1CCN(c2ccccc2F)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCC1 Fragment 2: [1*]C(=O)c1n[nH]c([14*])n1 ### Response: CC(C)c1nc(C(=O)N2CCC[C@@H]([NH+]3CCCC3)C2)n[nH]1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCOc1cc(NC(=O)c2ccncc2F)ccc1C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(=O)NNC1=CC(=O)CC(C)(C)C1 Fragment 2: [16*]c1ccc(OC)cc1 ### Response: COc1ccc(CC(=O)NNC2=CC(=O)CC(C)(C)C2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH2+]CCCC(=O)NC[C@@H]1CC[C@H](C(=O)[O-])O1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cc(OC)c(CCNC(=O)c2ccc(Br)cc2F)c(OC)c1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COc1ccccc1C(=O)Nc1ccccc1)Nc1ccc(Br)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccc2c(c1)CCO2 Fragment 2: [5*][NH+]1CCCn2nc([14*])cc2C1 ### Response: COC(=O)c1cc2n(n1)CCC[NH+](Cc1ccc3c(c1)CCO3)C2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+](C)[C@@H](CNC(=O)c1ccccc1C(F)(F)F)c1ccc(F)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(cc1NC(N1CCC(CC1)C(N(CCCC)C)=O)=O)C#N ### Response: CCCCN(C)C(=O)C1CCN(C(=O)Nc2cccc(C#N)c2)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(CNC(=O)[C@H](C)S(=O)(=O)c2ccc(C)cc2C)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=c1n(C)c(=O)n(c2c1n(Cc1ccc(F)cc1)c(n2)N1CCC(C)CC1)C ### Response: CC1CCN(c2nc3c(c(=O)n(C)c(=O)n3C)n2Cc2ccc(F)cc2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])c1ccccc1 Fragment 2: [16*]c1ccccc1 ### Response: CCCCN(c1ccccc1)S(=O)(=O)c1cccc2nonc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [3*]OCC[4*] ### Response: CCCOCC[NH+]1CCC[C@H](c2cc(N3CCOCC3)nc(C)n2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1c(C#N)ccc2ccccc12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1Cl Fragment 2: [16*]c1c(C)nn(C)c1C ### Response: Cc1nn(C)c(C)c1C[C@@H](C)NC(=O)c1c[nH]nc1-c1ccccc1Cl
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)[C@@H](C)S(=O)(=O)Cc1csc(-c2ccccc2F)n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=S(=O)([N-]c1ccc(-c2ccc3nncn3n2)cc1)c1cc(F)ccc1F ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? C[C@H]1Cc2ccccc2[C@H]1NC(=O)N(CC[NH+](C)C)Cc1ccco1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN1C(=O)c2ccccc2N[C@@H]1c1cnc(C2CCC2)s1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c(-c2ccccc2)cc(CCCN(C(=O)C2CC=CC2)C)[nH]1 ### Response: CN(CCCc1cc(-c2ccccc2)n[nH]1)C(=O)C1CC=CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1(C)C[C@@](O)(CC[C@@H]2CCCO2)C(C)(C)O1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(C)cc1 Fragment 2: [3*]Oc1ccc(Cl)cc1C ### Response: Cc1ccc(OCC(=O)Oc2ccc(Cl)cc2C)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCN1CCCC1=O)N[C@H]1CC[NH+](CC2CCCC2)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(Cc1ccc(cc1)N[C@@H](c1ccccc1)CC)N ### Response: CC[C@@H](Nc1ccc(CC(N)=O)cc1)c1ccccc1
functional_group
### Instruction: Does the molecule contain a ester group? COc1cc(N2C[C@@H](C)O[C@@H](c3ccc(F)cc3)C2)ccc1[N+](=O)[O-] ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CC(=O)N(CC)C1 Fragment 2: [5*]Nc1nc2c(s1)C[C@@H](CC)CC2 ### Response: CC[C@H]1CCc2nc(NC(=O)[C@H]3CC(=O)N(CC)C3)sc2C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(S(=O)(=O)NCC2CCN(S(=O)(=O)c3cccnc3)CC2)cc1F ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCN([C@@H]1CCS(=O)(=O)C1)S(=O)(=O)c1ccc2c(c1)CCC2 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitrile group? CCOC(=O)CCNC(=O)N1CCCC[C@H]1c1cccc(OC)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? C=CCCC[C@H](C)[NH+]1CCC(NC(=O)c2ccc(C)s2)CC1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCn1c2ccccc2c2cc(NC(=O)c3cccc(N4NC(=O)[C@@H]5CC=CC[C@H]5C4=O)c3)ccc21 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@H]2C[NH2+]C[C@@H]2[C@@H]1CC Fragment 2: [12*]S(=O)(=O)CC=C ### Response: C=CCS(=O)(=O)N1C[C@H]2C[NH2+]C[C@@H]2[C@@H]1CC
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(cc1OC)F)CNC(NC[C@H](c1ccccc1F)O)=O ### Response: COc1cc(F)cc(CNC(=O)NC[C@@H](O)c2ccccc2F)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CCCCC1=O)CN(C1CC1)[C@@H]1CS(CC1)(=O)=O ### Response: O=C1CCCCN1CN(C1CC1)[C@H]1CCS(=O)(=O)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CNC(=O)c1ccc(-c2ccc(Cl)cc2)o1)Nc1ccccc1Br ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(OC)c(OC)c1 Fragment 2: [1*]C(=O)C1CCCCC1 ### Response: COc1ccc(-c2c(C)n[nH]c2NC(=O)C2CCCCC2)cc1OC
functional_group
### Instruction: Does the molecule contain a thiol group? Cc1cc(C(F)(F)F)n2nc([C@H]3CCCCN3S(=O)(=O)N3CCCC3)cc2n1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccc(F)cc1F)Nc1c[nH]c(=O)[nH]c1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)OC(F)F)C(=O)NC[C@H](N1CCOCC1)c1ccc(cc1)F ### Response: O=C(NC[C@@H](c1ccc(F)cc1)N1CCOCC1)c1ccc(OC(F)F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc2ccccc2n2c(=O)n(C[C@H](C)NC(=O)CCCn3cncn3)nc12 ### Response: 4
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=C1CN(c2ccc(NC(=O)c3ccc(Cl)cc3F)cc2Cl)CCN1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)[C@H]1c2cccn2CCN1C(=O)Nc1ccccc1Cl ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H]1CN(C(=O)c2cn(Cc3cccc(Cl)c3)nn2)CC[NH+]1C ### Response: Yes