task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a nitrile group? CCNC(=O)N1CC[C@@H]([NH2+][C@@H](C)c2ccc(F)cc2OC(F)F)C1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(N(C)Cc2ccccc2)=O)c2c(nc(C3CC3)c1)n(nc2C)C(C)(C)C ### Response: Cc1nn(C(C)(C)C)c2nc(C3CC3)cc(C(=O)N(C)Cc3ccccc3)c12
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(OC)ccc(cc1)CN/C(N1CCC(CC1)C)=[NH+]/C ### Response: C/[NH+]=C(/NCc1ccc(OC)cc1)N1CCC(C)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(sc(n1)[C@@H]1CCCO1)C(N(CCCC)CC)=O ### Response: CCCCN(CC)C(=O)c1cnc([C@@H]2CCCO2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1ccc(N2CC[C@@H]3CCCC[C@@H]3C2)[nH+]c1N ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CNC(=O)C1(c2cccc(F)c2)CC1)Cn1cc[nH+]c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccccc1Sc1c(nn(C([C@@H]2N(S(=O)(c3ccccc3)=O)CCC2)=O)c1C)C ### Response: Cc1nn(C(=O)[C@H]2CCCN2S(=O)(=O)c2ccccc2)c(C)c1Sc1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[C@@H](C([1*])=O)C([6*])=O Fragment 2: [5*]NC1CCCCCCC1 ### Response: O=C(C[C@@H](C(=O)Nc1ccc2c(c1)OCCO2)C(=O)c1ccccc1)NC1CCCCCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CN([5*])c2ccccc2O1 Fragment 2: [12*]S(=O)(=O)CC ### Response: CCS(=O)(=O)N1C[C@H](C(=O)N[C@@H](C)CCc2ccccc2)Oc2ccccc21
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@H]1Cc2ccccc2N1CCNC(=O)C1(C#N)CCCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](CCO)C(C)C Fragment 2: [1*]C(=O)N[5*] ### Response: CC(C)[C@H](CCO)NC(=O)N[C@@H]1CCC[C@H](S(C)(=O)=O)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(S(N)(=O)=O)cc(NC(=O)CCC(=O)c2ccc(Br)cc2)c1C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c12n(c(nc1cccc2)C(F)(F)F)CC(N1CCN(S(=O)(=O)c2ccc(cc2)C)CC1)=O ### Response: Cc1ccc(S(=O)(=O)N2CCN(C(=O)Cn3c(C(F)(F)F)nc4ccccc43)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1ccc(Cl)cc1 Fragment 2: [5*]N([5*])c1ccccc1 ### Response: CCOC(=O)CN(c1ccccc1)S(=O)(=O)c1ccc(Cl)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(O)c(C[NH+]2CCc3ccccc3C2)cc1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1nn(C)c2c1COc1ccccc1-2 Fragment 2: [5*]N(C)c1cc(Cl)ccc1C ### Response: Cc1ccc(Cl)cc1N(C)C(=O)c1nn(C)c2c1COc1ccccc1-2
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1ccc(cc1)NC(NC(C)(C)c1cccc(C)c1)=O)CCC(NC)=O ### Response: CNC(=O)CCOc1ccc(NC(=O)NC(C)(C)c2cccc(C)c2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(S(=O)(=O)Nc2nc(C(=O)NCc3ccc4c(c3)OCO4)cs2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)CSc1nnc(-c2ccc3c(c2)OCO3)n1-c1ccccc1)c1ccccc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@H]1CCC[C@@H](S(C)(=O)=O)C1 Fragment 2: [6*]C(=O)C(F)(F)F ### Response: CS(=O)(=O)[C@@H]1CCC[C@H](C(=O)C(F)(F)F)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1Nc2ccccc2NC2=C1C(=O)CC(C)(C)C2 Fragment 2: [3*]Oc1ccc([16*])cc1 ### Response: CCC(=O)Oc1ccc([C@H]2Nc3ccccc3NC3=C2C(=O)CC(C)(C)C3)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)=C1[C@H]2CC[C@@H]1[C@@H](C(=O)Nc1cc(C)cc(C)c1)[C@@H]2C(=O)[O-] ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? Cc1ccc(CNc2ncnc(NNC(=O)c3ccccc3)c2N)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](O)CN1CCN(C(=S)Nc2ccc(Br)cc2)C1=S ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1nc([14*])c(C)s1 Fragment 2: [1*]C(=O)c1cccc[n+]1[O-] ### Response: Cc1ccc(-c2nc(NC(=O)c3cccc[n+]3[O-])sc2C)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1c(C)nn([9*])c1C Fragment 2: [5*]Nc1ncccc1F ### Response: Cc1nn(-c2ccccc2)c(C)c1CNc1ncccc1F
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nc2n(n1)CCC[C@@H]2NS(=O)(=O)N1CCC(C(C)(C)C)CC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(c1ccccn1)N1CCC([NH+]2CCC[C@H](C(=O)N3CCOCC3)C2)CC1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(CNC(=O)NC[C@@H](CC(C)C)C(=O)[O-])s1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@H]2[C@H](CC1)C[C@H](C(=O)[O-])[NH+]2C1CCS(=O)(CC1)=O ### Response: O=C([O-])[C@H]1C[C@H]2CCCC[C@@H]2[NH+]1C1CCS(=O)(=O)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(ccc1Cl)C(N/N=C(/C)c1ccc(O)cc1)=O)Cl ### Response: C/C(=N/NC(=O)c1ccc(Cl)cc1Cl)c1ccc(O)cc1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1ccc([C@@H](C)NC(=O)N(C2CC2)[C@H](C)c2ccco2)cc1F ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(F)cc1 Fragment 2: [5*]NCc1cccc(F)c1 ### Response: O=C(NCc1cccc(F)c1)[C@@H]1CCCN(c2nn3cc(-c4ccc(F)cc4)nc3s2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COc1nncc2ccccc12)NCc1ccc(Cl)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc2c(c1)CCCN2C(=O)C1CCN(c2ccc(-n3nc(C)cc3C)nn2)CC1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C([NH3+])(CC)c1onc(n1)CCC)C ### Response: CCCc1noc(C([NH3+])(CC)CC)n1
functional_group
### Instruction: Does the molecule contain a phenol group? COCCN1CC[NH+](CC2(CS(C)(=O)=O)CCC2)CC1=O ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? CC1=NN(c2ccc(C(=O)N3CC[NH+](Cc4ccco4)CC3)cc2)CC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]([8*])O Fragment 2: [5*]NS(=O)(=O)CCOC ### Response: COCCS(=O)(=O)NC[C@H](O)c1c(F)cccc1F
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1cc(S(=O)(=O)NC[C@H]2CCCO2)c(C)cc1C ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. c1ccc2c(NCc3nnc(C4CCC4)o3)cccc2c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(NCCc1sccc1)=O)NC(Cc1cn(c2c1cccc2)C)=O ### Response: Cn1cc(CC(=O)NNC(=O)NCCc2cccs2)c2ccccc21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(-c2cc(Cl)ccc2Cl)c(C(=O)[O-])c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C)cc1NC(=O)c1cc(-c2ccc(C)o2)nc2ccccc12 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? COc1cc2nc(CN(C)Cc3ccccc3Br)[nH]c(=O)c2cc1OC ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C(=O)N1CC[C@@H](Oc2cccc(Cl)c2)C1)c1cccnc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. n1nc(sc1)NC(=O)CCC(=O)[O-] ### Response: O=C([O-])CCC(=O)Nc1nncs1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCCCOc1cccc(NC(=O)N[C@@H]2C[C@H]2C)c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cc(NS(=O)(=O)c2ccc(N3C(=O)[C@@H]4[C@@H](C3=O)[C@H]3C=C[C@@H]4C3)cc2)nc(OC)n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? CC(C)COc1ccc(C(C)(C)C(=O)NCC#N)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. s1c(C(N2CCN(CC2)c2cnccn2)=O)ccc1 ### Response: O=C(c1cccs1)N1CCN(c2cnccn2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1nc2c(F)cccc2s1 Fragment 2: [1*]C(=O)[C@H](C[8*])N[5*] ### Response: O=C(N[C@@H](Cc1ccccc1)C(=O)NCc1cccnc1)c1nc2c(F)cccc2s1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNS(=O)(=O)[C@H]1CCOC[C@H]1Cc1ccc(Cl)cc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)[C@H]1Nc2ccc(F)cc2[C@H]2C=CC[C@@H]12 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1noc(CCCC(=O)Nc2ccc3c(c2)CC(=O)N3)n1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? c1ccc2c(c1)C[C@@H]([NH2+]C[C@H]1CNc3ccnn3C1)CO2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H](CO)[C@@H](C)NC(=O)NCc1cccc(N(C)C)c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(CNC(=O)N[C@H](C)c2ccc(Cl)s2)n1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(CCc1cn[nH]c1)C(=O)[C@@H]1[C@@H]2C=C[C@@]3(CN(C4CCCCCC4)C(=O)[C@@H]13)O2 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C(=O)N[C@H](C)c2ccccc2C)c2cnn(C(C)C)c2n1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(c1NC(C(NC1CC1)=O)=O)C(=O)N1CCCCC1 ### Response: O=C(Nc1ccccc1C(=O)N1CCCCC1)C(=O)NC1CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([14*])nn1 Fragment 2: [3*]OCC ### Response: CCOC(=O)c1ccccc1NC(=O)c1ccc(N2CCCC2)nn1
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(C[NH+]1CC=C(c2c[nH]c3ccccc23)CC1)NCCOc1ccccc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCc1ccnc(OC2CCC2)c1)[C@H]1C[C@@H]1c1cc(F)ccc1F ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccccc1C(=O)NC1CC[NH+]([C@H](C)c2ccccc2Cl)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(Cl)ccc1)CN(C(=O)Cc1ccc(C)c(O)c1)CC[NH+](C)C ### Response: Cc1ccc(CC(=O)N(CC[NH+](C)C)Cc2cccc(Cl)c2)cc1O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1OCC[C@H]1Sc1ccnc2ccccc12 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)C[C@@H]1CCCCN1c1ncc(Cl)cc1F ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](Nc1ncnc2c1CCCCC2)C(=O)[O-] ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)C(=O)c1cn2ccccc2n1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1O)C(=O)N[C@@H]1[C@@H](CCCC1)O)OC ### Response: COc1ccc(C(=O)N[C@H]2CCCC[C@H]2O)cc1O
canonicalization
### Instruction: Canonicalize the following SMILES string. CCN[C@H](C(C)(C)[NH+](CC)CC)c1c(N)ncc(c1)C ### Response: CCN[C@@H](c1cc(C)cnc1N)C(C)(C)[NH+](CC)CC
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn(CCO)c(C)c1C[NH+]1CCC(CC[NH+](C)C)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(C(=O)C(N[C@H]1CC[C@H]([NH+](C)C)C1)=O)c1ccc(OC)cc1 ### Response: COc1ccc(NC(=O)C(=O)N[C@H]2CC[C@H]([NH+](C)C)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(CNC(=O)CCc2cc(Cl)cs2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [5*]N([5*])CC ### Response: CC[C@H](C)N(CC)C(=O)C[C@@H]1CCCC[NH2+]1
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(F)Oc1ccc(cc1)C(NCc1ccccc1CN1C(CCC1)=O)=O ### Response: O=C(NCc1ccccc1CN1CCCC1=O)c1ccc(OC(F)F)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(C)cc2C[C@H](C(NCc3sc4c(n3)cccc4)=O)Oc12)C ### Response: Cc1cc2c(cc1C)O[C@@H](C(=O)NCc1nc3ccccc3s1)C2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Clc1ccc(C2([NH2+]C3CCCC3)CCOCC2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(-c2cnc3c(c2)CN(C(=O)c2ccc4c(c2)OCCO4)CC3)cc1OC ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC[4*] Fragment 2: [4*]CCN1CC[NH2+]CC1 ### Response: CCC(C)(C)c1ccc(OCCN2CC[NH2+]CC2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCNC(=O)[C@H]1CN(Cc2ccccc2)CCO1)Nc1ccccc1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)C[C@H]1NC(=O)C[C@@]12CSCCC2(C)C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C(=O)OCC[NH+](C)C(C)(C)C)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCc1ccccc1[N+](=O)[O-])NCc1cccnc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(CC(Nc2cccc(NC(C)=O)c2)=O)nc(-c2cccc(C(F)(F)F)c2)nn1 ### Response: CC(=O)Nc1cccc(NC(=O)Cn2nnc(-c3cccc(C(F)(F)F)c3)n2)c1
functional_group
### Instruction: Does the molecule contain a amine group? COc1cc(Cl)ccc1/N=C/c1cc(Br)ccc1O ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Clc1cc(CN2CCN(c3ccccc3)CC2)cc(Cl)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1csc([14*])n1 Fragment 2: [9*]n1cccn1 ### Response: O=C(NCCc1csc(-n2cccn2)n1)c1ccno1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1ccc(CCNC(=O)Nc2nnc(CC)s2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H](NC(=O)c1ccc(C=O)cc1)c1noc(Cc2ccccc2)n1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? CC[C@H](C)N(C)c1ccccc1C[NH2+]C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([16*])cc1 Fragment 2: [8*]C(F)(F)F ### Response: CN1C(=O)C[C@H](C(=O)Nc2ccc(C(=O)[O-])cc2)S/C1=N\c1cccc(C(F)(F)F)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc([C@H]([NH2+]Cc2ccc(N3CCCCC3)cc2)C2CCOCC2)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(C(=O)c1cc(C(C)C)n(C(C)(C)C)n1)c1ccc(C#N)c(Cl)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H]1COCCN1C(=O)NCc1ncn(C)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@H](C)C(=O)[O-] Fragment 2: [1*]C(=O)[C@@H]1CC2=c3ccccc3=[NH+][C@H]2[C@@H]2c3ccccc3C(=O)N12 ### Response: CC(C)[C@H](NC(=O)[C@@H]1CC2=c3ccccc3=[NH+][C@H]2[C@@H]2c3ccccc3C(=O)N12)C(=O)N[C@H](C)C(=O)[O-]
canonicalization
### Instruction: Canonicalize the following SMILES string. Nc1cnc(Oc2cncnc2)cc1 ### Response: Nc1ccc(Oc2cncnc2)nc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. NC(=O)c1ccccc1N[C@@H]1CCCCC[C@@H]1C(=O)[O-] ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+]C[C@H]1CCCO[C@@H]1c1ccc(CC(C)C)cc1 ### Response: 3