task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(N(C)C)=O)NC(Nc1c(cc(cc1)F)Cl)=O ### Response: CN(C)C(=O)CNC(=O)Nc1ccc(F)cc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH3+][C@@H](Cc1cccc(F)c1F)[C@@H]1OC[C@H]2CCCN2C1 ### Response: [NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1noc(C[4*])n1 Fragment 2: [4*]Cc1ccccc1 ### Response: C[NH+]1CCN(Cc2noc(COCc3ccccc3)n2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1cc2c(s1)-c1ccccc1S(=O)(=O)C2)N1CCc2ccccc21 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aldehyde group? C[C@H]1CC[C@H](C(C)(C)c2ccc(Cl)cc2F)[C@H](O)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](C)C[NH+](CC)Cc1cnc(N2CC[NH+](C)CC2)nc1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cncn1 Fragment 2: [4*]Cc1ccc([14*])nc1 ### Response: O=C(NCc1ccc(-n2cncn2)nc1)N(C[C@H]1CCOC1)C1CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H]2N(C([C@@H]([C@@H]2CC=1)c1ccc(cc1Cl)Cl)=O)O ### Response: O=C1[C@H](c2ccc(Cl)cc2Cl)[C@@H]2CC=C[C@@H]2N1O
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccnc1C[NH+]1CCN(Cc2ccc(Cl)cc2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ketone group? CC[C@@H](C(=O)c1ccc(C)cc1)[C@@H]1c2cc(Br)ccc2OC(=O)[C@@H]1C(=O)OC ### Response: Yes
functional_group
### Instruction: Does the molecule contain a nitrile group? C[C@H]1C[C@H]1C(=O)Nc1cccc(C(=O)N(c2ccc(C#N)cc2)C2CC2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C(=O)NC1CCC(C(=O)OC(C)(C)C)CC1)c1ccccc1 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc(C=O)o1 Fragment 2: [16*]c1ccc(OC)c([N+](=O)[O-])c1 ### Response: COc1ccc(-c2ccc(C=O)o2)cc1[N+](=O)[O-]
functional_group
### Instruction: Does the molecule contain a halide group? Cc1ccc[nH+]c1N1CCN(C(=O)CCn2nc(C)c(C)c2C)CC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. N([C@H]1C=CS(=O)(=O)C1)(c1ccc(cc1)Cl)C(=O)Cc1ccc(OC)cc1 ### Response: COc1ccc(CC(=O)N(c2ccc(Cl)cc2)[C@H]2C=CS(=O)(=O)C2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1C=C[C@@H]([NH3+])C1 Fragment 2: [5*]NC[C@@H](C)CCO ### Response: C[C@@H](CCO)CNC(=O)[C@H]1C=C[C@@H]([NH3+])C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1sccc1C Fragment 2: [8*][C@H](O)c1sccc1C ### Response: Cc1ccsc1[C@@H](O)C1(c2ccccc2)CCC1
functional_group
### Instruction: Does the molecule contain a amide group? COc1cc(C)c(NC(=O)c2cc(C)no2)cc1OC ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc2c(c1)OCCO2 Fragment 2: [5*]N1CCC([15*])CC1 ### Response: COC(=O)C1CCN(C(=O)C[NH+]2CCC[C@@H]2c2ccc3c(c2)OCCO3)CC1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cccc(NC(=O)c2cc(-c3ccco3)nc3ccccc23)n1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c12n(CC=C)c(nc1cccc2)[C@H](C)NC(COc1c(ccc(c1)C)C)=O ### Response: C=CCn1c([C@H](C)NC(=O)COc2cc(C)ccc2C)nc2ccccc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCc1cc(Cl)no1)Nc1ccc2occc(=O)c2c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1[C@@H](C(=O)[O-])CCN1C(=O)CCN1C(=O)CCC1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CS(=O)(=O)/N=C(\[O-])CCCSc1ccccc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1Nc2c(F)ccc([N+](=O)[O-])c2[C@H]2C=CC[C@H]21 Fragment 2: [16*]c1ccccc1O ### Response: O=[N+]([O-])c1ccc(F)c2c1[C@H]1C=CC[C@H]1[C@@H](c1ccccc1O)N2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C/C(=N\Nc1ncnc2sc(C)c(C)c12)c1cccc(OC(F)F)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(ncn1-c1ccc(cn1)C(Nc1c(OCC)c(Cl)ccc1)=O)cccc2 ### Response: CCOc1c(Cl)cccc1NC(=O)c1ccc(-n2cnc3ccccc32)nc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C1CCC(C)(C)CC1 Fragment 2: [1*]C(=O)CC(=O)[O-] ### Response: CN(C(=O)CC(=O)[O-])C1CCC(C)(C)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC(CC)[S@](=O)CCC(=O)[O-] ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)NC(=O)[C@H](C)NC(=O)C1=Cc2cc(OC)ccc2OC1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1cccc(-c2cc3ccccc3[nH]2)c1)[C@@H]1CCC[NH+](C2CCSCC2)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-n2nnnc2SCC(=O)N[C@H]2CCCC[C@H]2C)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(-c2nnc(C3CC[NH+](Cc4ccc5ncccc5c4)CC3)o2)s1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CCc2sc(C(=O)Nc3cc(F)ccc3F)cc2C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CC[C@@H]1NC(=O)NC1=O)NCc1cn2cc(Cl)ccc2n1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@H]1C(C#N)=C(N)O[C@H]2N=NC(C)=C12 Fragment 2: [16*]c1ccc(OC)c([16*])c1 ### Response: COCc1cc([C@H]2C(C#N)=C(N)O[C@H]3N=NC(C)=C23)ccc1OC
functional_group
### Instruction: Does the molecule contain a ester group? CO[C@]1(C)C[C@H](NC(=O)N2CCOC[C@@H]2C2CC2)C1(C)C ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCNS(=O)(=O)c1ccc(C)c(C(=O)N2CC[S@@](=O)C(C)(C)C2)c1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1cc2c(cc1OC)CN(C(=O)Nc1cc(C)cc(C)c1)CC2 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CCNC(=O)c1ccc(O)c(Cl)c1)Nc1ccncc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CSC[C@@H](C)N(C)C(=O)N[C@H]1CCC[NH+](C)C1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C1CCCCC1)S(=O)(=O)N1CCN(C(=O)c2ccc(Br)s2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [1*]C(=O)C[4*] ### Response: CC(C)(C)n1ncc2c1CCC[C@H]2NC(=O)CSc1nc2ccccc2o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cscc1[C@H](Br)c1ccc2[nH]c(=O)c(=O)[nH]c2c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(/C=C\c1ccccc1)NCCn1ncc2c(=O)n(Cc3cccc(F)c3)cnc21 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(C1)c1scc(C[NH2+]Cc2ccc(cc2)N2CCCCCC2)n1 ### Response: c1cc(N2CCCCCC2)ccc1C[NH2+]Cc1csc(C2CC2)n1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc([C@]2(C)NC(=O)N(CC(=O)Nc3cccc(OC(F)(F)F)c3)C2=O)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? O=C(Nc1ccc(OC[C@@H]2CCCO2)cc1)N1CCN(C2CCCC2)C(=O)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1csc(N[5*])n1 Fragment 2: [5*]N1C[C@H](C)O[C@@H](C)C1 ### Response: C[C@H]1CN(Cc2csc(NC(=O)[C@@H]3CC(=O)N(C)C3)n2)C[C@H](C)O1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1ccc([C@@H]([NH2+][C@H]2CCO[C@]3(CCSC3)C2)C2CC2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1ccccc1O[C@@H]1CCCC[C@@H]1[NH3+] ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CS(=O)(=O)N1CCCN(Cc2ncn(-c3ccccc3)n2)CC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](Nc1cccc(CN2CCCCC2=O)c1)C(=O)Nc1cccc([N+](=O)[O-])c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(O)c(-c2nc([C@H]3C[NH+]4CCN3CC4)no2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1nc(N)nc(N)n1 Fragment 2: [11*]Sc1ccc(C)cc1C ### Response: Cc1ccc(SCc2nc(N)nc(N)n2)c(C)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN1C(=O)S/C(=C\c2ccc(OCc3ccc([N+](=O)[O-])cc3)c(Cl)c2)C1=O ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? O=C(CSCc1ncn(-c2ccccc2)n1)NCc1cccs1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccc(Cl)s1 Fragment 2: [4*]C1([C@H]([8*])O)CCCC1 ### Response: O[C@@H](c1ccc(Cl)s1)C1([NH+]2CCCC2)CCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCc1sc(C)nc1C Fragment 2: [5*]NC(N[5*])=[NH+]C ### Response: C/[NH+]=C(/NCCc1sc(C)nc1C)N[C@@H]1CCC[C@H](C(F)(F)F)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NCc1nnc2n1CCCCC2)c1cncn1-c1ccc(F)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+]1CCC(=NNC(=O)c2cc(-c3ccccc3)nc3ccccc23)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? N#C[C@@H]1CCCC[C@H]1OC(=O)CCc1cc(Cl)cs1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[NH+](Cc1ccccc1NC(C)=O)[C@@H]1CCN(c2ccccc2)C1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(CNC(=O)N[C@H]2CCC[C@H](S(=O)(C)=O)C2)c(N(C)C)cc(C)cc1 ### Response: Cc1ccc(CNC(=O)N[C@H]2CCC[C@H](S(C)(=O)=O)C2)c(N(C)C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H](C)O[3*] Fragment 2: [5*]Nc1ccc([16*])cc1 ### Response: Cc1ccnc2nc(C(=O)O[C@H](C)C(=O)Nc3ccc(Oc4ccccc4)cc3)nn12
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1noc(C)c1[C@@H](C)NC(=O)Nc1ccc(NC(=O)[C@H]2CCCO2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O1CCCC[C@H]1CC[C@H]([NH2+]C)c1c(cc(F)c(c1)C)F ### Response: C[NH2+][C@@H](CC[C@@H]1CCCCO1)c1cc(C)c(F)cc1F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH2+]C/C=C/c1cccc(F)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CSc1ccccc1NC(=O)c1cc2n(n1)[C@H](C(F)(F)F)C[C@H](c1ccc3c(c1)OCO3)N2 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(/N=C2/C=C([O-])[C@@H](NO)c3ccccc32)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CN(CCn2cc[nH+]c2)CC[C@@H]1[NH3+] ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(ccc1CC)ncc(C#N)c2Nc1cc(OC)ccc1OC ### Response: CCc1ccc2ncc(C#N)c(Nc3cc(OC)ccc3OC)c2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCC[C@@H]([15*])C1 Fragment 2: [4*]Cc1ccc(Cl)c(F)c1 ### Response: CNC(=O)[C@@H]1CCC[NH+](Cc2ccc(Cl)c(F)c2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc([16*])ccc1C Fragment 2: [5*]NC[C@](C)(O)CCC(C)C ### Response: CC(=O)Nc1cc(NC(=O)NC[C@](C)(O)CCC(C)C)ccc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1(C)C[C@H]([NH2+]C[C@@H]2CCC[C@@H]2NS(C)(=O)=O)C(C)(C)O1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? [NH3+][C@@H](Cc1cccc(F)c1F)[C@H]1CN2CCC[C@@H]2CO1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCC Fragment 2: [1*]C(=O)[C@H]1C[NH2+]CCN1[5*] ### Response: CCNC(=O)[C@H]1C[NH2+]CCN1[C@@H](C)C1(C)CC1
functional_group
### Instruction: Does the molecule contain a halide group? CCc1ccc(C(=O)Nc2ccc(OC)c(S(=O)(=O)N3CCOCC3)c2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C1SC(=N)N([10*])C1=O Fragment 2: [8*]C(F)(F)F ### Response: N=C1S/C(=C\c2ccc([N+](=O)[O-])cc2)C(=O)N1c1ccccc1C(F)(F)F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccc(Cl)cc1 Fragment 2: [1*]C(=O)C(=O)NNC(=O)CC(C)(C)C ### Response: CC(C)(C)CC(=O)NNC(=O)C(=O)NCc1ccc(Cl)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(=O)n(cc(Cl)c(=O)[nH]1)Cc1nc(COc2ccc(C)cc2)sc1 ### Response: Cc1ccc(OCc2nc(Cn3cc(Cl)c(=O)[nH]c3=O)cs2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1[nH]c2ccccc2c1[C@@H]1c2ccccc2C(=O)N1CC(=O)NCCC(C)C ### Response: 4
functional_group
### Instruction: Does the molecule contain a ether group? CCCOc1ccc(N2C[C@H](C)C(=O)NC2=O)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccc(-c2nnc3sc(NC(=O)COc4cc(C)cc(C)c4)nn23)cc1OC ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H](c1nc(CC(C)C)no1)N1Cc2ccccc2C1=O ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1CC)NC(=O)NCC(Nc1ccc(cc1)OC)=O ### Response: CCc1ccc(NC(=O)NCC(=O)Nc2ccc(OC)cc2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1nc(-c2cccs2)cc1C(=O)NCCc1ccccc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)CC[8*] Fragment 2: [1*]C(=O)c1nc2c(C)cccn2c1C[4*] ### Response: Cc1cccn2c(C[NH+]3CCc4sccc4C3)c(C(=O)N(C)CCc3ccccc3)nc12
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(c1cc(cc(c1)OC)OC)N(Cc1occc1)c1sc2c(n1)ccc(c2)F ### Response: COc1cc(OC)cc(C(=O)N(Cc2ccco2)c2nc3ccc(F)cc3s2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(CC)S(=O)(=O)c1ccc(Cl)c(NC(=O)C2CCC2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](C[NH+]1CCCCC1)[NH2+][C@@H]1CCCS[C@@H]1C ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C1Nc2c(c(=O)oc3ccccc23)[C@H](c2cccc([N+](=O)[O-])c2)N1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(c1CNC(NCC)=O)OC ### Response: CCNC(=O)NCc1ccccc1OC
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2nc(COC(=O)c3cc(C#N)cn3C)no2)cc1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCCCNC(=O)Nc1ccc(OC(F)F)c2ncccc12 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC1CC1 Fragment 2: [4*][C@H](C)/C([O-])=N/S(=O)(=O)c1cccc2cc(C)cnc12 ### Response: Cc1cnc2c(S(=O)(=O)/N=C(\[O-])[C@@H](C)OCC3CC3)cccc2c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Clc1ncc(Cl)c(Oc2ccccc2)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ncc(CN(C)C(=O)c2ccc(-c3ccco3)[nH]c2=O)s1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)CCOc1ccc(NC(=O)N[C@H]2CCCC[C@@H]2O)cc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? [NH3+][C@@H](CC(=O)[O-])c1cccc2ccccc12 ### Response: 3