task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNC(=O)[C@H](C)CN(C)Cc1cc(=O)n2cccc(C)c2[nH+]1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1C[C@](C[NH3+])(N2CCc3ccccc32)CS1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc2c1O[C@@H](C)[C@H]2C Fragment 2: [5*]N1CCN([5*])CC1 ### Response: C[C@@H]1Oc2c(C(=O)N3CCN(C(=O)C4CC4)CC3)cccc2[C@@H]1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSc1ccccc1NC(=O)CC[NH+]1CCC2(CC1)OCCO2 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C([NH3+])C1([C@@H](c2c(F)c(ccc2)F)O)CCC(C)(C)CC1 ### Response: CC1(C)CCC(C[NH3+])([C@H](O)c2cccc(F)c2F)CC1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1ccc2sc(N(CC[NH+](C)C)C(=O)CSc3ccc(F)cc3)nc2c1C ### Response: Yes
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC(C)[C@H](CO)NC(=O)[C@@]1([NH3+])CCOC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)C[8*] Fragment 2: [4*]C[C@@H]1CC[C@H]([13*])O1 ### Response: Cc1cc(CS(=O)(=O)NC[C@@H]2CC[C@H](C(=O)[O-])O2)no1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C#CCN(CC(=O)[O-])C(=O)[C@H]1C[NH2+]C[C@H]1C ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(NC[C@H](c2ccccn2)N2CCOCC2)n2nc(C)cc2n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1ccccc1 Fragment 2: [8*]Cc1ccc(OC)cc1 ### Response: COc1ccc(C[C@@H]2[NH2+]C[C@H](Sc3ccccc3)[C@H]2O)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(F)c(N[C@@H]2CCOC3(CCCC3)C2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH+](CC)C1(C(=O)c2ccc(F)cc2)CCCC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? Cn1ncc2c1CCC[C@@H]2[NH+](C)Cc1c(Cl)nc2sccn12 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cc(ccc1OCC)NC[C@@H](O)CN1CCOCC1 ### Response: CCOc1ccc(NC[C@@H](O)CN2CCOCC2)cn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1CC(c2ccccc2)=NN1C1=NC(=O)S/C1=C\OCC Fragment 2: [16*]c1ccc(Cl)cc1 ### Response: CCO/C=C1\SC(=O)N=C1N1N=C(c2ccccc2)C[C@@H]1c1ccc(Cl)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [NH+](CC(N1CCN(c2cc(ccc2)C)CC1)=O)(C)CCO ### Response: Cc1cccc(N2CCN(C(=O)C[NH+](C)CCO)CC2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CSc1nnc(-c2cccnc2)n1Cc1ccccc1)N1CCOCC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)C[C@@H](Cc1cccc(Cl)c1)[NH2+]C[C@H]1CCCS1(=O)=O ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccc(C)cc1 Fragment 2: [5*]N([5*])c1cc([16*])ccc1Cl ### Response: Cc1ccc(CNC(=O)CN(c2cc(C(F)(F)F)ccc2Cl)S(C)(=O)=O)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1n(CC)nc(C([O-])=O)c1Br ### Response: CCn1cc(Br)c(C(=O)[O-])n1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(-n2ncc(c2C)[C@H](O)C)nc(cc(n1)C)C ### Response: Cc1cc(C)nc(-n2ncc([C@@H](C)O)c2C)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)C[NH+](C)Cc2ccc(Cl)nc2)c(C)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N/C(=N\OC(=O)COc1ccccc1Cl)c1ccc(Cl)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(CC(C)C)cc(NC(=O)Nc2ccc(C(NC)=O)cc2Cl)cn1 ### Response: CNC(=O)c1ccc(NC(=O)Nc2cnn(CC(C)C)c2)c(Cl)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)OC)NCc1ccc(cc1)C ### Response: COc1ccc(NCc2ccc(C)cc2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1CCCCCCC1 Fragment 2: [1*]C(=O)c1cnn2c1nc([O-])c1ccccc12 ### Response: O=C(NC1CCCCCCC1)c1cnn2c1nc([O-])c1ccccc12
functional_group
### Instruction: Does the molecule contain a amide group? CS[C@@H](C)C(=O)N1CCC[C@H](O)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCCC1 Fragment 2: [1*]C(=O)c1ccc(S([12*])(=O)=O)cc1 ### Response: C[C@H]1CN(C(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)CCO1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])c1nc2ccc(Cl)cc2cc1F ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]1Cc2ccccc2O1 Fragment 2: [5*][NH2+][C@@H]1CCO[C@]2(CCOC2)C1 ### Response: c1ccc2c(c1)C[C@H](C[NH2+][C@@H]1CCO[C@]3(CCOC3)C1)O2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccoc1 Fragment 2: [4*]Cc1ccc(Cl)s1 ### Response: C[C@H]([NH2+]Cc1ccc(Cl)s1)c1ccoc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN1C(=O)/C(=C/c2ccc(Cl)cc2)S/C1=N\c1ccncc1Cl ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CC[C@H](NC(NNc2ccccn2)=O)C1=O)CCc1ccccc1 ### Response: O=C(NNc1ccccn1)N[C@H]1CCN(CCCc2ccccc2)C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@H](N(C(CSc2sc(NC(=O)CCC)nn2)=O)[C@@H]1C)C ### Response: CCCC(=O)Nc1nnc(SCC(=O)N2[C@H](C)CCC[C@H]2C)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCN(CC1CC1)C(=O)c1ccn2cncc2c1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C)c(CC(=O)N2C[C@H]3CC[C@@H]2CN(C(=O)c2ccccc2)C3)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2ccc(OC(=O)c3cccnc3N3CCCCC3)cc2c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccncc1 Fragment 2: [12*]S(=O)(=O)c1ccc2nc([14*])cc([16*])c2c1 ### Response: CCN(CC)S(=O)(=O)c1ccc2nc(-c3ccncc3)cc(C(=O)[O-])c2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1cccc([N+](=O)[O-])c1 Fragment 2: [7*]C1C(=O)NN([10*])C1=O ### Response: Cc1ccc(N2NC(=O)/C(=C/c3cccc([N+](=O)[O-])c3)C2=O)cc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. c1n(CC(=O)N(CC)C2CC2)c(=O)c(cc1[N+](=O)[O-])C(OC)=O ### Response: CCN(C(=O)Cn1cc([N+](=O)[O-])cc(C(=O)OC)c1=O)C1CC1
functional_group
### Instruction: Does the molecule contain a amide group? COc1cc(NC(=O)[C@H](CC(C)C)N2C(=O)c3ccccc3C2=O)c(OC)cc1Cl ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1c(C)[nH]c(C(=O)COc2ccc(NC(C)=O)cc2)c1C ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(Cl)cc1Cl Fragment 2: [3*]OCc1nc(C#N)c(N[5*])o1 ### Response: N#Cc1nc(COc2ccc(Cl)cc2Cl)oc1NCCN1CCOCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=S)C1(C(=O)N2CC[NH+]3CCC[C@H]3C2)CCCCCC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? Cc1ccc(C2=NN(C(=O)COc3ccc([N+](=O)[O-])cc3)[C@H](c3ccco3)C2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc2c1NC(=O)CO2 Fragment 2: [4*]Cc1nccn1C ### Response: Cn1ccnc1COc1cccc2c1NC(=O)CO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(N[C@H](Cn1cc[nH+]c1)c1ccccc1)c1nc2ccccc2c(=O)[nH]1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CS(=O)C[8*] Fragment 2: [14*]c1cc([14*])on1 ### Response: Cc1cnc(C[S@](=O)Cc2cc(-c3ccccc3)on2)o1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cccc([C@@]2(CC(=O)N(C)Cc3nc4ccccc4s3)CC(=O)N(C3CCCC3)C2=O)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(N(C)C(=O)C2=CCCCO2)cc1Cl ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12n(c(n(c1cccc2)CCC)=O)CCC(=O)Nc1c(c(ccc1)Cl)C ### Response: CCCn1c(=O)n(CCC(=O)Nc2cccc(Cl)c2C)c2ccccc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1cccc(S(=O)(=O)[N-]c2nccs2)c1)c1ccon1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1ccc(C(=O)N2CCN(Cc3c[nH]nc3-c3ccccc3F)CC2)o1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)Nc1cc(NC(C)=O)cc(C(=O)OCC#Cc2ccccc2)c1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(Br)c(F)c1 Fragment 2: [16*]c1ccc(Br)c(F)c1 ### Response: CCN1CCO[C@@H](COc2ccc(Br)c(F)c2)C1
functional_group
### Instruction: Does the molecule contain a amide group? CCc1ccc(CCNC(=O)C(=O)Nc2cccc(SC)c2)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@H]2O[C@@H]1[C@H](C(N1CCC(=CC1)c1ccc(cc1)OCC)=O)C2 ### Response: CCOc1ccc(C2=CCN(C(=O)[C@@H]3C[C@H]4CC[C@@H]3O4)CC2)cc1
functional_group
### Instruction: Does the molecule contain a ester group? Nc1cnccc1SCc1ncon1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCNC(=O)NC(=O)CN1C(=O)N[C@](Cc2ccccc2)(c2ccccc2)C1=O ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(c1ccc(Br)o1)N(CCO)Cc1ccccc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CSc1ncc(-c2ccccc2)n1C1CC1)NCC(F)(F)F ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+](C)C Fragment 2: [4*]Cc1cc([16*])cs1 ### Response: C[NH+](C)[C@@H]1CCCN(Cc2cc(C(N)=O)cs2)C1
functional_group
### Instruction: Does the molecule contain a phenol group? CC(C)NC(=O)C[C@H](C)NC(=O)N1CCN(c2ccccc2O)CC1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(c1ccc(C[NH2+]C)cc1F)C(C)C ### Response: 0
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@H](NC(=O)CCSc1ccccn1)[C@H]1CCCO1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCS(=O)(=O)N(C)C1CC[NH+](Cc2ccc(C(=O)OC)c(F)c2)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a thiol group? COc1ccc(-c2cc(C(=O)NC[C@@H]3CCOC3)c3ccccc3n2)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CC(=O)N(C[8*])/C(=N/c2ccc(F)cc2)S1 Fragment 2: [16*]c1ccc(OC)c(OC)c1 ### Response: COc1ccc(CN2C(=O)C[C@@H](C(=O)Nc3ccccc3)S/C2=N\c2ccc(F)cc2)cc1OC
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(N2C(=O)S/C(=C\c3cccc(F)c3)C2=O)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)OC(=O)c1nc2ccccc2nc1Nc1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NC(CCC(=O)c2ccc(Br)cc2)=O)c(C)c(cc(S(=O)(=O)N)c1)C ### Response: Cc1cc(S(N)(=O)=O)cc(NC(=O)CCC(=O)c2ccc(Br)cc2)c1C
functional_group
### Instruction: Does the molecule contain a ether group? [NH3+][C@H]1CCC[C@@H]1CC[NH+]1CC[C@H](N2CCOCC2)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1ccc(S(=O)(=O)NCCOCC(F)(F)F)cc1F ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([14*])nn1 Fragment 2: [5*]Nc1ccc(F)cc1F ### Response: CNS(=O)(=O)c1cc(-c2ccc(Nc3ccc(F)cc3F)nn2)ccc1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1c(C(=O)/C=C/c2cnn(C)c2)nnn1-c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(N(C(c2ccncc2)=O)Cc2c([nH]c3c(cccc3c2)C)=O)cccc1C)C ### Response: Cc1cccc(N(Cc2cc3cccc(C)c3[nH]c2=O)C(=O)c2ccncc2)c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)N1CCC[C@H](O/N=C(/N)Cc2cccnc2)C1=O ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N/C=C/N[5*] Fragment 2: [5*]N(C)C ### Response: CN(C)C(=O)N/C=C/NC(=O)N(C)C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(N1CCN(CCc2ccccc2)CC1)C1(c2cc(-c3cccs3)on2)CC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1cc(CN[C@@H]2CC[C@@H]([NH+](C)C)C2)c(-c2ccncc2)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C(NC2CCCCCC2)=O)cnc1-n1c(C)c(c(C)n1)C ### Response: Cc1nn(-c2ccc(C(=O)NC3CCCCCC3)cn2)c(C)c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(=O)[nH]c(/N=C(\N)N(C)C)n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@@H]1CC[C@](O)(Cc2nc(-c3ccccc3)cs2)C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc2ccc(NC(=O)[C@H](C)Oc3ccc4c(c3)OCO4)cc2c(=O)n1-c1ccccc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. CC[NH+]([C@@](C(=O)c1ccc(c(c1)OC)Cl)(C)CC)CC ### Response: CC[NH+](CC)[C@@](C)(CC)C(=O)c1ccc(Cl)c(OC)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccncc1NC(=O)N[C@@H]1CCC[C@H](S(C)(=O)=O)C1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOCC(=O)Nc1ccc(S(=O)(=O)/N=C(/C)[O-])cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(NCC(=O)N(C)C2CCC(C)CC2)ccc1-n1cnnn1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cc(F)cc(CNC(=O)NC[C@@H]2CC[NH+](CC(C)C)C2)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1ccccc1-c1ncc(C[NH+]2CCn3cncc3C2)s1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)Nc1ncnc(Nc2ccc(I)cc2)c1N)C(=O)[O-] ### Response: Nc1c(Nc2ccc(I)cc2)ncnc1Nc1ccc(C(=O)[O-])cc1
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccc(-c2cc(C(=O)N3CCC[C@H]3c3cc(C)on3)no2)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? C=CCc1cc(CNC(=O)c2ccco2)cc(OC)c1OC ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ncccn1cc(C[NH+](C[C@@H](C)Cc1ccc(cc1)OC)C)n2 ### Response: COc1ccc(C[C@H](C)C[NH+](C)Cc2cn3cccnc3n2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1ccc(OP(=O)(c2ccccc2)c2ccccc2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)c1ccccc1[16*] Fragment 2: [16*]c1ccccc1 ### Response: COC(=O)c1ccccc1N(C)C(=O)CN1CCN(c2ccccc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@H](C)C[NH+](C[C@@H](O)CCO[C@@H]2C[C@@H]3CC[C@@]2(C)C3(C)C)C1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@]1(CSc2ccccc2C(=O)N2CCN(Cc3ccc4c(c3)CCO4)CC2)NC(=O)NC1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. CC[C@H](NC(CNC(c1cc(C)ccc1)=O)=O)C(OC)=O ### Response: CC[C@H](NC(=O)CNC(=O)c1cccc(C)c1)C(=O)OC