task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1ccc(OC(=O)CSCc2ccc(C)cc2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(N(CC)C([C@@H]2CC(N(C3CCCC3)C2)=O)=O)CCCCC1 ### Response: CCN(C(=O)[C@@H]1CC(=O)N(C2CCCC2)C1)C1CCCCC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(NC(=O)c2ccc(N3C(=O)[C@H]4CCCC[C@H]4C3=O)cc2)c1C ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1c(C)nc2n(c1=O)C[C@@H](C(=O)N1CCN(C(c3ccccc3)c3ccccc3)CC1)CS2 ### Response: 5
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@H](C)NC(=O)[C@H]1CCC[NH+](Cc2ccc(C)c([N+](=O)[O-])c2)C1 ### Response: 5
functional_group
### Instruction: Does the molecule contain a amide group? CC1=NC(=O)[C@@H](CC(=O)Nc2ccc(C(C)C)cc2)C(C)=N1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1cc(OCC(=O)N(Cc2ccc(C(C)C)cc2)[C@@H]2CCS(=O)(=O)C2)ccc1Cl ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(NC(=O)[C@@H]2CCCN(S(=O)(=O)c3cc4c(cc3C)NC(=O)[C@@H](C)O4)C2)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(c1cc([N+](=O)[O-])ccc1Cl)N1CCN(Cc2ccc3c(c2)OCO3)CC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(cc1)C[NH+](C)C1CCN(CC1)C(c1sccc1OC(F)F)=O)C(F)(F)F ### Response: C[NH+](Cc1cccc(C(F)(F)F)c1)C1CCN(C(=O)c2sccc2OC(F)F)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)[C@H](Oc1cccc(Cl)c1)C(=O)NCc1nnc2n1CCCC2 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(CSc1nc2ccccc2c(=O)n1-c1ccc(F)cc1F)Nc1ccc(F)c([N+](=O)[O-])c1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H]1CCN(C(=O)Nc2ccc(O[C@@H]3CCOC3)cc2)[C@H](C)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)c1[nH+]ccn1[C@H](C)C(=O)Nc1ncc(Cc2ccccc2)s1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CCCC1(C)C Fragment 2: [5*][NH+]1CC[C@H]([NH3+])[C@H](C)[C@H]1C ### Response: C[C@@H]1[C@@H](C)[NH+]([C@@H]2CCCC2(C)C)CC[C@@H]1[NH3+]
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Fc1ccc(F)c([C@@H]2[C@H]3[NH+]=c4ccccc4=C3CCN2CCCn2cccn2)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(N/C=C2/C(=O)N(C(=O)c3cc(OC)ccc23)c2c(C)cc(C)cc2)c1OC ### Response: COc1ccc2c(c1)C(=O)N(c1ccc(C)cc1C)C(=O)/C2=C/Nc1ccccc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. C[NH+](C)CCNC(C[C@H]1N(Cc2c(cccc2F)Cl)CCNC1=O)=O ### Response: C[NH+](C)CCNC(=O)C[C@@H]1C(=O)NCCN1Cc1c(F)cccc1Cl
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC[C@@H]1CCCc2ccccc21 Fragment 2: [5*]N1CCc2cc(S(N)(=O)=O)ccc21 ### Response: NS(=O)(=O)c1ccc2c(c1)CCN2CC(=O)NC[C@@H]1CCCc2ccccc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [16*]c1ccccc1F ### Response: Cc1c(F)cccc1NC(=O)N(C)Cc1ccccc1F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H]1c2ccsc2CCN1C(=O)C[NH+](CCC(F)(F)F)C1CCC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1C[C@@H](C)O[C@H](C)C1)(c1ccc(cc1)CNC(=O)N[C@@H](C)c1ccc(o1)C)=O ### Response: Cc1ccc([C@H](C)NC(=O)NCc2ccc(C(=O)N3C[C@@H](C)O[C@H](C)C3)cc2)o1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1[C@H](C=C(COC)N=1)C[NH2+]C1CCN(c2cc(ccc2)-c2csc(C)n2)CC1 ### Response: COCC1=C[C@H](C[NH2+]C2CCN(c3cccc(-c4csc(C)n4)c3)CC2)N=N1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc2c(c1)nnn2[C@@H]([C@@H](C)C[NH2+]C1CC1)C ### Response: C[C@H]([C@@H](C)C[NH2+]C1CC1)n1nnc2ccccc21
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]([NH3+])COCc1cc(Cl)ccc1Cl ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[C@@H](NC(=O)NNc1ccc(C(C)(C)C)nn1)c1ccccn1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCNC(=O)[C@H](C)Sc1cccc(N)c1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[C@@H]1CCOc2ccccc21 Fragment 2: [16*]c1ccc(OC)cc1 ### Response: COc1ccc([C@@H](O)[C@@H](C)NC(=O)C[C@@H]2CCOc3ccccc32)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)N1CC[C@@H]([NH2+][C@@H](C)c2ccc(SC(C)C)cc2)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCCn1c(C)cc(C2=NN/C(=N\c3ccc(F)cc3)SC2)c1C ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nn(C)c(OC)c1CNc1ncnc2[nH]ncc12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(F)cccc1Cl Fragment 2: [5*]N(C)C[8*] ### Response: CN(Cc1c(F)cccc1Cl)C(=O)CNC(=O)c1sc2ccccc2c1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. NC(/C(C#N)=C\c1oc(cc1)-c1cccc(c1Cl)Cl)=O ### Response: N#C/C(=C/c1ccc(-c2cccc(Cl)c2Cl)o1)C(N)=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCC Fragment 2: [9*]n1cc([16*])c2ccc(C)cc21 ### Response: CCCn1cc(CC[NH3+])c2ccc(C)cc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(F)cc1C Fragment 2: [14*]c1csc(C)n1 ### Response: Cc1nc(-c2ccc(C(=O)Nc3ccc(F)cc3C)cc2)cs1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](C)NC(=O)Cc1csc(NC(=O)Nc2ccc(Cl)cc2)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](CO)(NC(=O)c1c(cccc1)Cl)[C@@H](c1ccc(N)cc1)O ### Response: Nc1ccc([C@@H](O)[C@H](CO)NC(=O)c2ccccc2Cl)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1cc(C(N)=O)c(NC(=O)c2ccc3sccc3c2)n1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1([C@H]([NH3+])Cc2c(F)cccc2Cl)CCCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc([16*])cc1C Fragment 2: [5*]N[C@H](C)CC[8*] ### Response: CC[NH+]1CCN(c2ccc(NC(=O)N[C@H](C)CCc3ccccc3)c(C)c2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C=CCOc1ccc2ccccc2c1C#N ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1c(F)c(F)nc(F)c1F Fragment 2: [4*]CCC(F)(F)F ### Response: Fc1nc(F)c(F)c(NCCC(F)(F)F)c1F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](Sc1nc2cc(Cl)ccc2n1Cc1ccccc1)C(=O)N1CCC(C(N)=O)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C)n2nc(SCC(=O)N3CCC(C(=O)[O-])CC3)nc2n1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc([16*])ccc1NC Fragment 2: [8*]C(F)(F)F ### Response: CNc1ccc(C(F)(F)F)cc1C(=O)NCc1ccco1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)Nc1ncnc(NNC(=O)c2ccco2)c1[N+](=O)[O-] ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[C@@H](C(=O)Nc1ccc(C)nc1C)/C(N)=N/O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCC(=O)N1CCC[C@H](C(=O)NNC(=O)CNc2ccc(C)cc2C)C1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(C[NH+]2C[C@@H]3CC[C@H](C2)N(C(=O)Cn2cc(C)cn2)C3)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H]1CCCN([5*])C1 Fragment 2: [12*]S(=O)(=O)c1cc(F)ccc1F ### Response: C#CCOC[C@H]1CCCN(S(=O)(=O)c2cc(F)ccc2F)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1Oc2ccccc2N(CCC(=O)N2C[C@@H](C)c3ccccc32)C1=O ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCN1C[C@@H](C(=O)N2CCCC(c3ccccc3)(c3ccccc3)C2)CC1=O ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ncnc(Sc2nc(C)cc(C)n2)c1N ### Response: 0
functional_group
### Instruction: Does the molecule contain a aldehyde group? COc1cc(/C=C2/N=C(c3ccccc3)OC2=O)ccc1OCC(=O)[O-] ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)c1cccc(NC[C@@H](O)c2cc(Cl)cc(Cl)c2)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(OCc1ccccn1)c1ccc(COc2ccccc2Cl)o1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCCNC(=O)NNC(=O)[C@@H](C)Oc1ccc(C#N)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)(C)OC1CCN(Cc2[nH]cc(-c3cccc(Br)c3)[nH+]2)CC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1nc2c(s1)COc1ccccc1-2)Nc1c(F)cccc1F ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. [S@](=O)(CC)[C@H]1C[C@H](CCC1)NC(=O)N1CCSCC1 ### Response: CC[S@@](=O)[C@@H]1CCC[C@H](NC(=O)N2CCSCC2)C1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@@H]1C(=O)CCN(c2ccc(F)cc2F)[C@H]1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)CCC1=O Fragment 2: [1*]C(=O)c1ccc([16*])cc1 ### Response: COC(=O)c1cc(CNC(=O)c2ccc(N3C(=O)CCC3=O)cc2)ccc1OC
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@](O)(CNc1ccc(C#N)cc1F)c1ccco1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)c1cc(F)c(F)c(F)c1)c1cccc(N2CCCC2=O)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=Cc1ccc(N2CCC[C@@H](c3nc4ccccc4[nH]3)C2)c([N+](=O)[O-])c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#CCCc1c(-c2ccccc2)nn(-c2nc3ccccc3s2)c1O ### Response: 3
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@@H]1Cc2ccccc2N1C(=O)CSc1nnnn1-c1ccc(Br)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(CCCCNC(c2ccc(F)cc2)=O)cnnc1 ### Response: O=C(NCCCCn1cnnc1)c1ccc(F)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c(=O)oc2ccccc21 Fragment 2: [5*]N1CCCC1(C)C ### Response: CC1(C)CCCN1C(=O)Cn1c(=O)oc2ccccc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1c(C#N)c(=O)n(C)c(=O)n1C Fragment 2: [5*]Nc1ccc2c(c1)CCC(=O)N2CCC ### Response: CCCN1C(=O)CCc2cc(Nc3c(C#N)c(=O)n(C)c(=O)n3C)ccc21
functional_group
### Instruction: Does the molecule contain a ester group? O=C(NC[C@H]1CCS(=O)(=O)C1)N1CCC[C@H]([NH+]2CCCC2)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C)c(NC(=O)CNC(=O)CCc2nc3ccccc3c(=O)[nH]2)c(C)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(/C=N/c2ccc([N+](=O)[O-])cc2O)c2ccccc12 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)n1ncc(C(=O)Nc2nnc(C3CC3)s2)c1C1CC1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1c(C)sc(NC(=O)c2cc(S(N)(=O)=O)c(Cl)cc2Cl)c1C(N)=O ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCN1CC[NH2+]CC1)N1CCCCCC1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1nc(S[11*])c2c3c(sc2n1)CCCC3 Fragment 2: [16*]c1ccc2c(c1)OCCCO2 ### Response: c1cc2c(cc1Sc1nc(CN3CCOCC3)nc3sc4c(c13)CCCC4)OCCCO2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(ccc1C(=O)NC[C@H](c1cccc(c1)OC)[NH+](C)C)O)Cl ### Response: COc1cccc([C@@H](CNC(=O)c2ccc(O)c(Cl)c2)[NH+](C)C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC Fragment 2: [4*]CCC ### Response: CCCN[C@@]1(C#N)CCC[C@H](N2CC[NH+](C)C(C)(C)C2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS(=O)(=O)CCOc1ccc(Cl)cc1NC1CCSCC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)[C@@H](C)NC(=O)COC(=O)c1cc(=O)[nH]c2ccccc12 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H]([NH2+]C)CNCc1cscc1C ### Response: C[NH2+][C@H](C)CNCc1cscc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccccn1 Fragment 2: [1*]C(=O)C([1*])=O ### Response: COCCNC(=O)C(=O)NCc1ccccn1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)Cn1/c(=N/C(=O)CC)sc2c(OC)ccc(OC)c21 ### Response: CCCn1/c(=N/C(=O)CC)sc2c(OC)ccc(OC)c21
functional_group
### Instruction: Does the molecule contain a thiol group? COc1cc(C[NH+]2Cc3ccccc3O[C@@H](C)C2)cc(OC)c1OC ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CN1C(N[C@@](CC)(C1=O)c1ccccc1)=O)(OC(C)C)=O ### Response: CC[C@]1(c2ccccc2)NC(=O)N(CC(=O)OC(C)C)C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C([C@@H](C)[C@@H](C)[NH2+]CC1(CCC(C)(C)CC1)O)OC ### Response: COC(=O)[C@@H](C)[C@@H](C)[NH2+]CC1(O)CCC(C)(C)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]([NH2+][C@@H](CC(F)(F)F)c1ccc(F)cc1)c1ccccn1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cnc([N+](=O)[O-])n1 Fragment 2: [5*]Nc1sc(C)c(CC)c1C#N ### Response: CCc1c(C)sc(NC(=O)CCCn2cnc([N+](=O)[O-])n2)c1C#N
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cccc(/C=c2\sc3nc(=O)c(C)nn3c2=O)c1OC ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc([N+](=O)[O-])c(C)c1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: Cc1cc(C(=O)NNC(=O)CCC(=O)N2CCN(c3ccccc3)CC2)ccc1[N+](=O)[O-]
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(CCNC(=O)C(=O)Nc2c(C)cc(C)cc2C)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(C[n+]1ccccc1)NO ### Response: 0
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[NH+]1CCc2c(sc(NC(=O)c3ccccc3F)c2C#N)C1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)[C@H]1C[NH2+]CC[C@]12CCO[C@H](C)C2 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1C[C@@H]1C(=O)Nc1cccc(F)c1I ### Response: 0
functional_group
### Instruction: Does the molecule contain a phenol group? C[NH2+]C[C@@H]1CCCO[C@H]1C(C)(C)C ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(Nc2ccc(N3C(=O)CCCC3=O)cc2[N+](=O)[O-])cc1OC ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccccc1[C@H](CS([N-]c1ccc(-n2nccc2)cc1)(=O)=O)C ### Response: C[C@@H](CS(=O)(=O)[N-]c1ccc(-n2cccn2)cc1)c1ccccc1