task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[C@@H]1[C@@H](C)CCCN1C(=O)c1ccc(OC)nn1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(/N=C/c2ccc(O)c(O)c2)[nH+]c2ccccc21 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[C@@H](C)CC(C)C Fragment 2: [16*]c1cc[nH+]cc1 ### Response: CC(C)C[C@H](C)CC(=O)NCC1CCN(c2cc[nH+]cc2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([O-])[C@@H]1C[C@H]1c1cccc(F)c1F ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC[NH2+]CC[NH+](C)CC(C)(C)O ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)c1cc(Cl)ccc1OC Fragment 2: [1*]C(=O)[C@H]([4*])C ### Response: COc1ccc(Cl)cc1S(=O)(=O)N[C@H](C)C(=O)NCc1ccc2c(c1)OCO2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CNC(=O)[C@H](C)Nc1ccc(C(F)(F)F)cc1C(=O)[O-] ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? Cc1cccc(/C=C/C(=O)c2cncc(F)c2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COC[C@@H](NC(=O)c1ccccc1C(F)(F)F)c1ccc(F)c(F)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc([C@@H]2CC(=O)C3=C(C2)Nc2[nH]nc(O)c2[C@H]3c2ccc(Br)cc2)cc1OC ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. c1ccc([C@@H]2C[C@H]2C[NH2+]Cc2nc3c(s2)CCC3)cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1cc(Cl)cc(Cl)c1)C1CCN(S(=O)(=O)/C=C/c2ccccc2)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(OC)cc1 Fragment 2: [5*]N1CC([15*])C1 ### Response: COc1ccc(OCC(=O)N2CC(OCc3ccc(Cl)cc3)C2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2S/C(=C/C(=O)N[C@H](c3ccccc3)C)C(Nc2ccc1)=O ### Response: C[C@H](NC(=O)/C=C1/Sc2ccccc2NC1=O)c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@H]1CCOCCN1C(=O)NCc1cnc(-n2cncc2)cc1 ### Response: C[C@H]1CCOCCN1C(=O)NCc1ccc(-n2ccnc2)nc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1ccc(-c2cc[nH]n2)cc1)N[C@@H]1CCN(c2ccccc2)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H](C(=O)[O-])C(C)C Fragment 2: [4*][C@@H](C(=O)[O-])C(C)C ### Response: Cc1ccc(NC(=O)N[C@@H](C(=O)[O-])C(C)C)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1ccnc(NC(=O)c2ccc(SCc3ccccc3)cc2)c1=O ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2c(ccc(c2)OCC(N(C2CC2)CC2=CC3[C@@H](C=C2)N=CC=3)=O)cc1 ### Response: O=C(COc1ccc2ccccc2c1)N(CC1=CC2=CC=N[C@@H]2C=C1)C1CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(/C=N/NCCO)cc(OC)c1O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C(=O)[O-])[NH+]1CCc2ccccc2C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. CCOc1c(OC(COc2c(cc(C)cc2)C)=O)cccc1 ### Response: CCOc1ccccc1OC(=O)COc1ccc(C)cc1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1cc(Br)ccc1NC(=O)c1ccc(Br)cc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(-c2nnc(CN3CCC[C@H]3Cc3cccc(F)c3)o2)c(C)o1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? COc1cc(OC)cc([C@H]2Nc3nonc3NC3=C2C(=O)CCC3)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(=O)[O-] Fragment 2: [9*]n1c(CC)cc2ccccc2c1=O ### Response: CCc1cc2ccccc2c(=O)n1CC(=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@@H](N[C@@H](CO)c2cc(F)c(F)c(F)c2)C[NH+]1C1CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. CC(c1nc(N2CCN(C(C[NH+]3CCC(C)CC3)=O)CC2)cc(n1)C)C ### Response: Cc1cc(N2CCN(C(=O)C[NH+]3CCC(C)CC3)CC2)nc(C(C)C)n1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(CNC(=O)c1ccc2c(c1)OCO2)Nc1ccccc1N1CCCC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amine group? C#CCNC(=O)NNc1c(Cl)cc(Cl)cc1Cl ### Response: Yes
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1cc(C)c2nc(N3CCN(C(=O)[C@@H]4CCCCN4S(C)(=O)=O)CC3)sc2c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)Cn1cc(C(=O)O[C@H]2CCC[C@@H](C(F)(F)F)C2)nn1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1cccc2nonc12 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(C[4*])cc1 Fragment 2: [8*]CCCO ### Response: C[C@@H](C#N)Oc1ccc(C[NH+]2CCC[C@@H]2CCCO)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)CN1[C@@H](C(=O)NCc2n[nH]c(=S)n2C)CCC1=O)C ### Response: Cc1ccc(CN2C(=O)CC[C@@H]2C(=O)NCc2n[nH]c(=S)n2C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(n(C)ccn1)COc1c2c(OCC(=O)N2)ccc1 ### Response: Cn1ccnc1COc1cccc2c1NC(=O)CO2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cccc(OC[C@H](O)CNC(=O)Nc2c(C)cccc2C)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)(C)NC(=O)c1cccc([N-]S(=O)(=O)c2ccc(F)c(F)c2)c1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nc(NC(=O)c2ccccc2Cl)sc1Cc1ccccc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1nc(CC(C)C)cc1C(=O)N[C@@H]1CCC[NH+](Cc2cccnc2)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1NC(N[C@@H](C)CCCO)=O)Sc1scc(n1)C ### Response: Cc1csc(Sc2ccc(NC(=O)N[C@@H](C)CCCO)cc2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CSCN1[5*] Fragment 2: [1*]C(=O)c1ccoc1 ### Response: CC(C)CC[C@@H](C)NC(=O)[C@@H]1CSCN1C(=O)c1ccoc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(=O)NCCCN(C)C(=O)C1C[C@H](C)O[C@@H](C)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2c(c(CNC(N3CCN(CC3)c3[nH+]cc(cc3)-c3nc(C)on3)=O)c1)cccc2 ### Response: Cc1nc(-c2ccc(N3CCN(C(=O)NCc4cccc5ccccc45)CC3)[nH+]c2)no1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(noc(c1)C(C)C)NC(Cn1c(cccc1)=O)=O ### Response: CC(C)c1cc(NC(=O)Cn2ccccc2=O)no1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1n(ncc1C(=O)NC1CCN(c2cc(ccc2)F)CC1)C(C)C ### Response: Cc1c(C(=O)NC2CCN(c3cccc(F)c3)CC2)cnn1C(C)C
functional_group
### Instruction: Does the molecule contain a ether group? O=C(c1csc2c1CCCC2)N1CCO[C@H]2CCCC[C@H]21 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])cc1N1CCCC1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=[PH2][C@H](Cc1ccccc1)c1ccccc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(=O)N1CCC(N2CCN(C(=O)c3cccc(F)c3)CC2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=C(CSc1ncc(C(F)(F)F)cc1Cl)NCc1ccccc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C([O-])CC1CCN(S(=O)(=O)c2cc[nH]c2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? CN(C(=O)c1cccc(C(F)(F)F)c1F)C1CCCCC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(C[7*])cc1 Fragment 2: [5*]N1CCC[C@H](CC)C1 ### Response: CC[C@H]1CCCN(C(=O)/C=C/c2ccc(NC(C)=O)cc2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(-c2nnc(CN3CCCCC[C@H]3c3ccco3)o2)c(C)o1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)NNC([6*])=O Fragment 2: [5*]NCC[8*] ### Response: CCc1cnc(CCNC(=O)NNC(=O)[C@H]2CCCO2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CN(Cc2ccc(Cl)cc2Cl)C[C@H](C)O1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(NC(=O)[C@@H](Sc2nnnn2C[C@@H]2CCCO2)C(C)C)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cccc(c1C#N)CNc1cccc([N+](=O)[O-])c1C ### Response: Cc1c(NCc2ccccc2C#N)cccc1[N+](=O)[O-]
canonicalization
### Instruction: Canonicalize the following SMILES string. c12ccccc2N(C(=O)/C=C/C)C[C@@H](C(N1)=O)C ### Response: C/C=C/C(=O)N1C[C@H](C)C(=O)Nc2ccccc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(CC)(C(=O)[O-])N1C(=O)[C@@H]2[C@H](C1=O)C2(C)C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cn1c(=O)n([9*])c(=O)c2c1c1cc(C)ccc1n2C Fragment 2: [16*]c1ccccc1 ### Response: COc1cccc(Cn2c(=O)n(-c3ccccc3)c(=O)c3c2c2cc(C)ccc2n3C)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)CN1CCO[C@@H](CNC(=O)/C=C/c2ccnc(Cl)c2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(-c2occn2)ccc(c(NC(N2CCC[C@@H]2c2ccco2)=O)c1)C ### Response: Cc1ccc(-c2ncco2)cc1NC(=O)N1CCC[C@@H]1c1ccco1
functional_group
### Instruction: Does the molecule contain a amide group? NC(=O)Nc1ccc(NC(=O)[C@H]2CCN(c3cc(F)cc(F)c3)C2=O)cc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? CCOC(=O)c1cn(Cc2cccc(C(F)(F)F)c2)c2nc(C)ccc2c1=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc([16*])c([N+](=O)[O-])c1 Fragment 2: [4*]Cc1ccc([16*])cc1[N+](=O)[O-] ### Response: C[NH+](Cc1ccsc1)Cc1ccc(C(N)=O)cc1[N+](=O)[O-]
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nc([C@@H]2CN3CC[NH+]2CC3)nc([O-])c1F ### Response: 4
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)(C)C(=O)N1CCCc2cc(N)ccc21 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(C)c1ccc(C(=O)Nc2[nH]ncc2N)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? C=CC[NH+](CC(=O)[O-])[C@@H]1CCC[C@H](C(C)(C)C)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C([O-])c1ccc([C@H]2CCCN(C(=O)c3ccc4[nH]ccc4c3)C2)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(cc1)-n1/c(s/c(=C\c2ccc(c(c2)OC)OC)c1=O)=C(/c1nnc2n1CCCCC2)C#N ### Response: COc1ccc(/C=c2\s/c(=C(/C#N)c3nnc4n3CCCCC4)n(-c3ccccc3)c2=O)cc1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c([O-])oc2ccccc2c1=O Fragment 2: [16*]c1ccccc1 ### Response: CC(=O)[C@@H](O)[C@@H](c1ccccc1)c1c([O-])oc2ccccc2c1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(OC)ccc(/C=N/OCc2nc3c4c(n(CC(C)C)c(c4C)C)ncn3n2)c1 ### Response: COc1ccc(/C=N/OCc2nc3c4c(C)c(C)n(CC(C)C)c4ncn3n2)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nc(-c2cc([N+](=O)[O-])ccc2OC)n[nH]1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOCCN(C)S(=O)(=O)c1cc(Cl)ccc1C#N ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1cccc(NC(=O)CCn2[nH]c(=O)ccc2=O)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1CC[NH+](Cc2cc(=O)c(OCC(=O)NCc3ccco3)co2)CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]Cc1ccc(Br)cc1 Fragment 2: [5*][NH2+][C@@H](C)CC(C)(C)OC ### Response: COC(C)(C)C[C@H](C)[NH2+]Cc1ccc(Br)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH2+]C[C@]1(C)CCCO1 Fragment 2: [4*]C[C@]1(C)CCCO1 ### Response: C[C@@H]([NH2+]C[C@]1(C)CCCO1)C(=O)NC1CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)nc([C@@H](CC)NC(Nc2c(Cl)ccc(C#N)c2)=O)no1 ### Response: CC[C@@H](NC(=O)Nc1cc(C#N)ccc1Cl)c1noc(C)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(C)(C)N(Cc2c(C#N)c(nn2-c2ccccc2)C)CC[NH+](C)C1 ### Response: Cc1nn(-c2ccccc2)c(CN2CC[NH+](C)CC2(C)C)c1C#N
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)C[NH+]1CCCN(CC2CCCCC2)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS(=O)(=O)CS(=O)(=O)OCCCl ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(C)(C)C Fragment 2: [16*]c1ccccc1 ### Response: Cc1nn(-c2ccccc2)c(C)c1/C=N/NC(=O)c1n[nH]c2c1C[C@@H](CC(C)(C)C)CC2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H]([8*])CN[5*] Fragment 2: [1*]C(=O)C([1*])=O ### Response: Cn1cccc1[C@H](CNC(=O)C(=O)NCc1ccco1)[NH+]1CCCCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1[C@H]2CCO[C@@H]2C1(C)C Fragment 2: [1*]C(=O)CS(=O)(=O)C(C)C ### Response: CC(C)S(=O)(=O)CC(=O)N[C@@H]1[C@H]2CCO[C@@H]2C1(C)C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCc1cc(Cl)no1)Nc1ccc2occc(=O)c2c1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cn(c(c1)C(=O)OC)C)S(=O)(N(C)Cc1cc(ccc1)OC)=O ### Response: COC(=O)c1cc(S(=O)(=O)N(C)Cc2cccc(OC)c2)cn1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+]1CCN(CCOc2ccccc2Cl)CC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(C[C@H](C)N[C@H](C)c2ccccc2[N+](=O)[O-])n[nH]1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@@H]1[C@H](N(C(NC2CCN(CC2)C(=O)OC(C)C)=O)CCC1)C ### Response: CC(C)OC(=O)N1CCC(NC(=O)N2CCC[C@H](C)[C@H]2C)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cc(CO)c(Br)cc1OCc1ccc(F)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(C[NH2+]C1(c2ccc(Br)cc2)CCOCC1)Nc1ccccc1C(F)(F)F ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitro group? CCc1ccc(-c2nc(N)ccc2[N+](=O)[O-])cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC/[NH+]=C(/NCC#Cc1ccccc1)NC[C@@H]1CCO[C@@H]1c1ccccc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C/C=C/C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)[O-] ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1sc(=O)n(CCC(=O)NNc2ncccc2Cl)c1C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C(N)=[NH+]C[C@@H]1[13*] Fragment 2: [8*]CN=[N+]=[N-] ### Response: [N-]=[N+]=NC[C@H]1C[NH+]=C(N)N1c1cccc(F)c1