task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H](CO)C(C)C Fragment 2: [1*]C(=O)c1cc(N)n[nH]1 ### Response: CC(C)[C@H](CO)NC(=O)c1cc(N)n[nH]1
functional_group
### Instruction: Does the molecule contain a carboxyl group? N#Cc1cc2c(nc1NC(=O)CN1C(=O)[C@@H]3[C@H](C1=O)[C@@H]1C=C[C@H]3C1)CCC2 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(nc2c(c1C(=O)N1[C@H](CC)COCC1)ccc(c2)C)-c1cn(C)nc1 ### Response: CC[C@@H]1COCCN1C(=O)c1cc(-c2cnn(C)c2)nc2cc(C)ccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)N(C)c1ccc(OC(C)C)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=[N+]([O-])c1cccc([C@H]2Nc3c(Br)cccc3[C@@H]3C=CC[C@H]23)c1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)[C@@H]([15*])[C@H](O)N([10*])C1=O Fragment 2: [8*]CC(C)C ### Response: COc1ccc2c(c1)=C1CCN[C@H]([C@@H]3C(=O)N(CC(C)C)C(=O)N(CC(C)C)[C@H]3O)[C@H]1[NH+]=2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1Cc2c(CC1)ccc(c2)[C@@H](C)NC(C(=O)Nc1cc(c(OC)c(c1)F)F)=O ### Response: COc1c(F)cc(NC(=O)C(=O)N[C@H](C)c2ccc3c(c2)CCCC3)cc1F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ncsc1CCSc1nnc(-c2ccco2)n1CC(C)C ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1)[C@H](NC(=O)N[C@H]1[C@@](C)(CCC1)CO)c1ccco1 ### Response: C[C@@]1(CO)CCC[C@H]1NC(=O)N[C@@H](c1ccccc1)c1ccco1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(C1CCCC1)N1CCC[C@H]1Cn1nc(-c2cccs2)ccc1=O ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1csc(-n2nnc(C(=O)Nc3cccnc3Cl)c2C)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. S(=O)(N1CCC(C(Nc2c(OC)cc(OC)cc2)=O)CC1)(=O)C ### Response: COc1ccc(NC(=O)C2CCN(S(C)(=O)=O)CC2)c(OC)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOC(=O)c1cnn(-c2ccc(OC(F)(F)Cl)cc2)c1N ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1c2c(nn1-c1ccccc1)CCC2)c1ccc(Br)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [4*]CC(N)=O ### Response: CN(Cc1ncnn1C)C(=O)c1ccccc1OCC(N)=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(F)cc1S(=O)(=O)Nc1cccc(-c2csc3nc(C)cc(=O)n23)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1ccc(-c2n[nH]cc2CN(CC(=O)N(C)C)CC(F)(F)F)cc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amine group? COC(=O)c1cc(N)c(C(C)(C)C)c(N)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC[C@@H]1CC=CC[C@H]1C Fragment 2: [1*]C(C)=O ### Response: CC(=O)OC[C@@H]1CC=CC[C@H]1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H]1NC(=O)C[C@H](C)N(Cc2ccc(O)cc2)C1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C[NH2+][C@]1(CO)CCC[C@@H]1CC[NH+](C)CC1CCC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(Cc1ccccn1)C(=O)Nc1ccccc1SC(F)F ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cc(Br)cs1 Fragment 2: [5*]N[C@@H]1CCSc2c(F)cccc21 ### Response: Fc1cccc2c1SCC[C@H]2NCc1cc(Br)cs1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1[C@@H]1C[C@@H]1C(=O)Nc1cccc(OCC(N)=O)c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [16*]c1cc(Cl)c(OC)cc1OC ### Response: CCCN(CCC)C(=O)Nc1cc(Cl)c(OC)cc1OC
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(CN(C)C(=O)Nc2cccc(C(=O)N3CCCCC3)c2)s1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(N1C[C@H](C)O[C@H](C1)C)(=O)c1c(Br)ccc(Br)c1 ### Response: C[C@H]1CN(S(=O)(=O)c2cc(Br)ccc2Br)C[C@H](C)O1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccc(NC(=S)NC(=O)c2ccc(Cl)cc2Cl)cc1)c1cccs1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)c2nc(NC(=O)c3ccccc3S(C)(=O)=O)sc2c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? c1nc(N2CCC[C@H]([NH+]3CCCC3)C2)c2ccsc2n1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(NC(=O)Cc2nnc(S[C@@H](C)C(=O)Nc3nccs3)n2C)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H](C)COC Fragment 2: [5*]Nc1ccc([N+](=O)[O-])nc1 ### Response: COC[C@H](C)Nc1ccc([N+](=O)[O-])nc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(OC)c(NC(=O)c2cccc(NC(=O)C3CC3)c2)cc1F ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cn1cc[nH+]c1CN[C@@H]1CCC[C@@H]1[C@@H]1CCC[NH2+]1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(NC(=O)N(C)Cc2csc([C@H](C)OC)n2)cc1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? N#Cc1cc(Cl)nc(NNC(=O)c2ccccc2NCc2ccco2)c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CCOC(=O)[C@]1(C#N)C(N)=C(C#N)C2=C(CCCC2)[C@H]1c1ccccc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([O-])C1CCC(C[NH2+][C@H]2CCC[C@H](C3CC3)C2)CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [5*]N([5*])c1ncnc2ccsc12 ### Response: CCCN(CC(C)(C)C[NH3+])c1ncnc2ccsc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)Oc1ccc(C(=O)OCc2nc(C3CC3)cs2)cn1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH+](C)[C@H]1CCN(c2nc(Cl)ncc2Br)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(C[C@H](OC1)C(N)=S)CCc1ccc(OC)cc1 ### Response: COc1ccc(CCN2CCO[C@H](C(N)=S)C2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[C@H]([8*])N[5*] Fragment 2: [1*]C(=O)CO[3*] ### Response: C[C@H]1CCCN(C(=O)COC(=O)C[C@@H](NC(N)=O)c2ccc(Cl)cc2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCCC1 Fragment 2: [1*]C(=O)C[8*] ### Response: Cc1cc(NC(=O)CC2CCCC2)n([C@@H]2CCS(=O)(=O)C2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(OC[C@@H]1CN(Cc2ccccc2)CCO1)c1ccncc1Cl ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)[C@](C)([C@]1(C[NH3+])C[C@H](CC)CC1)O)Cl ### Response: CC[C@@H]1CC[C@](C[NH3+])([C@](C)(O)c2ccc(Cl)cc2)C1
functional_group
### Instruction: Does the molecule contain a ether group? CC[NH2+]Cc1c(C)nn(C)c1N1CCN2C(=O)NC[C@@H]2C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? Cc1ccc(NC(=O)[C@H]2C[C@H]2[N+](=O)[O-])cc1I ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(N[C@@]1(C(F)(F)F)C(=O)N=C2C1=C([O-])NC(=O)N2Cc1ccccc1Cl)c1cccnc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCC1 Fragment 2: [1*]C(=O)c1ccc([16*])cc1 ### Response: CC(C)(O)CCc1ccc(C(=O)N2CCCO[C@@H](C[NH+]3CCCC3)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)C1(C)CC[NH+](C[C@@H](O)c2ccccc2C)CC1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc2[nH]cc(CCNC(=O)C3CCN(c4ncnc5[nH]cnc45)CC3)c2c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccccc1Cl Fragment 2: [5*]N1CCN([5*])CC1 ### Response: CCc1ccc(N2CCN(C(=O)c3ccccc3Cl)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1[NH+]=c2ccc([N+](=O)[O-])cc2=C1CC[NH3+] Fragment 2: [6*]C(=O)[O-] ### Response: [NH3+]CCC1=c2cc([N+](=O)[O-])ccc2=[NH+][C@H]1C(=O)[O-]
functional_group
### Instruction: Does the molecule contain a halide group? O=C(Nc1ccccc1)c1nnc([C@H]2CCCN(C(=O)Nc3ccc(F)cc3)C2)s1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. S(C(N)=S)/C=C/C(=O)[O-] ### Response: NC(=S)S/C=C/C(=O)[O-]
functional_group
### Instruction: Does the molecule contain a amine group? CSCC[NH2+]C1CCN(c2ccc(-n3cnc4ccccc43)cc2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cn1nnc2c(N3CCN(CC(=O)Nc4ccc(F)cc4F)CC3)ncnc21 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nc(C)sc1CNC(=O)CCc1nc(-c2ccccc2C)no1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1cc([C@@H]2CC(=O)N3CN(c4ccc(Br)cc4)CSC3=C2C#N)ccc1O ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1[C@H](c2ccc(Br)cc2)OCCN1C(=O)NCCOc1cccnc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [14*]c1cscn1 ### Response: CCC([NH3+])(CC)C(=O)N(C)Cc1cscn1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(c(c1[N+]([O-])=O)[C@@H](CO)N)[N+](=O)[O-] ### Response: N[C@H](CO)c1c([N+](=O)[O-])cccc1[N+](=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@@H](C)NC(=O)COC(=O)c1c2c(nc3ccccc13)CCCCC2 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]([8*])O Fragment 2: [5*][NH+](C)C ### Response: Cn1nccc1[C@@H](O)C[NH+](C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CNc2c(c(=O)nc(S)n2[9*])C1 Fragment 2: [5*][NH+]1CNc2c(c(=O)nc(S)n2CC[8*])C1 ### Response: CCCC[NH+]1CNc2c(c(=O)nc(S)n2CCc2ccccc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NCc1cc(-c2cc(ccc2)C)ccc1)NC[C@H](C)C[C@H](C)O ### Response: Cc1cccc(-c2cccc(CNC(=O)NC[C@H](C)C[C@H](C)O)c2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC(=S)N[C@H]1CCCc2c1cnn2C)c1ccccc1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CNC(=O)[C@@H](C)CN(C)C(=O)c1ccc(-n2c(C)ccc2C)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CCC1CC1)C1([NH+]2CCCCC2)CCCC1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(NC(=O)C2(S(=O)(=O)c3ccc(Cl)cc3)CC2)c(Cl)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCN(CC)S(=O)(=O)c1ccc(Nc2ccc3c(c2)OCCCO3)c([N+](=O)[O-])c1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1ccsc1 Fragment 2: [6*]C(=O)C[7*] ### Response: CSc1ccc(C(=O)/C=C/c2ccsc2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(NC(=O)CC[NH2+][C@@H]2CCCN(c3cccnn3)C2)no1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aldehyde group? O[C@@H](CNc1ccc(OC(F)F)cn1)c1ccco1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(OCCSC2N([C@H]3[C@@H](CS(=O)(C3)=O)N=2)c2ccccc2OC)cc1 ### Response: COc1ccccc1N1C(SCCOc2ccccc2)=N[C@@H]2CS(=O)(=O)C[C@H]21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C)C(C)(C)CNC(=O)c1cc(NC(=O)C(C)(C)C)ccc1F ### Response: 3
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC(C)(CO)[C@@H](C[NH2+]C1CCN(c2ccccc2)CC1)c1ccccc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc2ccc(F)cc2s1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: COc1ccc(S(=O)(=O)CC(=O)N2CCN(c3nc4ccc(F)cc4s3)CC2)cc1
functional_group
### Instruction: Does the molecule contain a ether group? COc1ccccc1CNC(=O)C1(Cc2cc(-c3ccccc3C)no2)CCOCC1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(C(=O)CNC1=NS(=O)(=O)c2ccccc21)c1cccc(C#N)c1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CSC(C)(C)CNC(=O)Cc1c(C)nc2cc(=O)[nH]n2c1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)C[7*] Fragment 2: [7*]Cc1cc(F)c(F)c(F)c1 ### Response: O=C(/C=C/c1cc(F)c(F)c(F)c1)c1ccc([N+](=O)[O-])cc1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc([N+](=O)[O-])cnc1NCc1ccc(C(=O)[O-])o1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccc2cn[nH]c12 Fragment 2: [16*]c1cnn(C)c1 ### Response: Cn1cc([C@@H]2CN(Cc3cccc4cn[nH]c34)CCO2)cn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cnc(C)s1 Fragment 2: [5*]N(C)C[8*] ### Response: Cc1ncc(CN(C)C(=O)c2cccc3[nH]ncc23)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nsc(N2CCCN(S(=O)(=O)CCC3CC3)CC2)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([O-])CCC(=O)N1CCc2[nH]c3ccc(F)cc3c2C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(N2C(=O)/C(=C\c3scc(Br)c3)NC2=S)ccc(C(C)C)c1 ### Response: CC(C)c1ccc(N2C(=O)/C(=C\c3cc(Br)cs3)NC2=S)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(C(C)(C)CC[C@H]1C[NH+]1CCN(CC(C)(O)C)CC1)O ### Response: CC(C)(O)CN1CC[NH+](C[C@@H]2CCC(C)(C)[C@@H]2O)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCCCNC(=O)CSc1cc(C)c2ccccc2n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aldehyde group? O=C(NCCSc1c[nH]c2ccccc12)c1cnn2c1OCCC2 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCOCC1 Fragment 2: [4*][C@@H]([8*])CCOC ### Response: COCC[C@@H]([NH2+][C@H](C)C1CCOCC1)c1ccc(Cl)cc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? NC(=O)c1csc(NC(=O)c2ccco2)n1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. n1nc(SCC)sc1NC(=O)CCc1ccc(C)o1 ### Response: CCSc1nnc(NC(=O)CCc2ccc(C)o2)s1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(Cl)ccc1OC Fragment 2: [1*]C(=O)N1C[C@@H]([13*])O[C@@H](C)C1 ### Response: COc1ccc(Cl)cc1NC(=O)N1C[C@@H](c2ccccc2)O[C@@H](C)C1
functional_group
### Instruction: Does the molecule contain a amide group? C[NH+](C)[C@H](CNS(=O)(=O)c1ccc(C(F)(F)F)cc1)c1ccccc1Cl ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1c2ccc(F)cc2CC[C@@H]1C Fragment 2: [9*]n1cccn1 ### Response: C[C@H]1CCc2cc(F)ccc2N1C(=O)[C@@H]1CCCN(c2cc(-n3cccn3)ncn2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(C)=O Fragment 2: [5*]NCc1ccccc1 ### Response: CC(=O)N[C@H](C(=O)NCc1ccccc1)C(=O)Nc1ccc(C(C)C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCC(NC(N2CCCC[C@H]2CC(=O)C)=O)CC1 ### Response: CC(=O)C[C@@H]1CCCCN1C(=O)NC1CCCCC1