task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c(=O)oc2ccccc21 Fragment 2: [5*]N[C@@H](C)C[8*] ### Response: C[C@@H](Cn1c(=O)oc2ccccc21)NC(=O)c1ccccn1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1C(N=NN=1)C(SCC)SCC ### Response: CCSC(SCC)C1N=NN=N1
functional_group
### Instruction: Does the molecule contain a aldehyde group? O=C(Nc1ccc2scnc2c1)c1ccc2c(c1)OCO2 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc([C@@H](C[NH3+])OC(C)C)cc1F ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@]1(F)CCN(C(=O)COc2ccc(C(F)(F)F)cc2)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(N2CCN(c3ccc(C(=O)Nc4cccc(C#N)c4)cc3[N+](=O)[O-])CC2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1COCC[NH+]1CC[C@@]1(CCC(C)C)C[C@H](OCC1)C(C)C ### Response: CC(C)CC[C@@]1(CC[NH+]2CCOCC2)CCO[C@H](C(C)C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [15*][C@@H]1CC(=O)[C@H]2C(=Nc3ccccc3N3C(=O)c4ccccc4[C@H]23)C1 ### Response: O=C1C[C@@H](c2ccco2)CC2=Nc3ccccc3N3C(=O)c4ccccc4[C@@H]3[C@@H]12
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(NCCc1ccccn1)NC1CCN(C(=O)c2ccoc2)CC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN[C@@]1(C(=O)OC)CCC[C@H]([NH+](C)C2CCCCC2)C1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=S1(=O)CC[C@H](Cc2nc(-c3ccccn3)nn2Cc2ccccc2)C1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)[C@H]1COCCN1C(=O)c1csc(-c2ccoc2)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2C(=O)NC(c2cc(c1)NC([C@@H]1CCCN1S(=O)(c1ccc(OC)cc1)=O)=O)=O ### Response: COc1ccc(S(=O)(=O)N2CCC[C@H]2C(=O)Nc2ccc3c(c2)C(=O)NC3=O)cc1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[NH+](CCn1c(=O)oc2cccnc21)[C@H]1CCC[C@@H]1S(C)(=O)=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCCCC1 Fragment 2: [5*]NC1CCCCC1 ### Response: O=C(Nc1nc2ccccc2n1CC[NH+]1CCCCC1)NC1CCCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C)CC(N[C@H]1CCCc2nc(ncc12)C)=O ### Response: COCC(=O)N[C@H]1CCCc2nc(C)ncc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1C Fragment 2: [5*]N([5*])Cc1cc(=O)n2ccccc2[nH+]1 ### Response: COC(=O)CN(Cc1cc(=O)n2ccccc2[nH+]1)Cc1ccccc1C
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1ccc(C(C)C)cc1)N(C)C(=O)NCCCn1nccc1 ### Response: CC(C)c1ccc(CN(C)C(=O)NCCCn2cccn2)cc1
functional_group
### Instruction: Does the molecule contain a halide group? NC(=O)[C@@H]1COCCN1C(=O)c1cc2cc(F)ccc2o1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(cc(cc1[N+](=O)[O-])Br)/C=N/NC(Cn1c2c(c(c3c1cccc3)=O)cccc2)=O)[O-] ### Response: O=C(Cn1c2ccccc2c(=O)c2ccccc21)N/N=C/c1cc(Br)cc([N+](=O)[O-])c1[O-]
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C1=C(C)NC(=O)N[C@H]1[13*] Fragment 2: [16*]c1ccccc1[16*] ### Response: CC1=C(C(=O)Nc2ccccc2C)[C@H](c2ccccc2C(F)(F)F)NC(=O)N1
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1ccoc1C[NH+]1CC[C@@H](C)[C@H](C)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCc1nnc2n1N[C@H](c1ccc(OC)cc1)[C@H](C(=O)Nc1ccc(C)c(Cl)c1)S2 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccccc1Cl)[C@H]1CCCN(c2ccc(-n3ccnc3)nn2)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=S(=O)(NC[C@@H](c1ccccc1)c1c[nH]c2ccccc12)c1cccs1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amide group? CC(=O)c1c[nH]c(C(=O)N(C)CCC2CCN(c3cc[nH+]cc3)CC2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](C)C[NH+]1CCCN(C(=O)c2ccc(Cl)cc2)CC1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2cccc(C(=O)N[C@@H](c3n[nH]c(C)n3)C(C)C)c2n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [8*]C(C)(C)C ### Response: Cc1nnc(N2C(=O)C(O)=C(C(=O)c3cccs3)[C@@H]2c2ccc(C(C)(C)C)cc2)s1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#CCN1CCN(Cc2cccc(OCc3ccccc3C#N)c2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amine group? CCCN(CCO)C(=O)Nc1cccc(OC)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CCCN(c2ncnc(N)c2[N+](=O)[O-])C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cnc(-c2cccc(NC(=O)C(=O)N[C@@H]3CCN(c4ccccc4)C3)c2)o1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCC(=O)Nc1cccc(NC(=O)C(=O)N[C@H]2CC[C@@H]([NH+](C)C)C2)c1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. n1(c(nnn1)-c1cccc(c1)NC(=O)[C@@H]1[C@@H](C)Oc2c(cccc2)O1)C ### Response: C[C@H]1Oc2ccccc2O[C@@H]1C(=O)Nc1cccc(-c2nnnn2C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([16*])cc1 Fragment 2: [1*]C(=O)c1ccc(N[5*])cc1 ### Response: C[C@H](NC(=O)c1ccc(NC(=O)Nc2ccc(Cl)cc2)cc1)c1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nnc(N2CCN(C(=O)Cc3cccc(OC)c3)CC2)c2cccn12 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1CC[C@H](C(=O)Nc2ccc(F)c(-n3cccc3)c2)CN1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(C(=O)N2Cc3c(nc(s3)NC(=O)[C@@H]3CCCO3)CC2)cc(c(OC)c1OC)OC ### Response: COc1cc(C(=O)N2CCc3nc(NC(=O)[C@@H]4CCCO4)sc3C2)cc(OC)c1OC
functional_group
### Instruction: Does the molecule contain a thiol group? FC(F)(F)c1cccc2c1CCCC2 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C)[C@H]1CC[C@H](NC(=O)c2cc(F)ccc2Br)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCCCN(C(=O)c1cc(F)cc(F)c1)[C@H]1CCS(=O)(=O)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CN(C)C(=O)C1CCN(C(=O)NCc2cn(-c3ccccc3)nn2)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCN2[C@H]1CO[C@@H](C2)CNC(=O)Nc1cc2oc(C)nc2cc1 ### Response: Cc1nc2ccc(NC(=O)NC[C@@H]3CN4CCCC[C@@H]4CO3)cc2o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [15*]C1CC[NH+](C)CC1 ### Response: CCC(CC)[C@H](NC(=O)NC1CC[NH+](C)CC1)c1cccs1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)-n1nncc1)C(N1CCS(=O)(=O)C(C)(C)C1)=O ### Response: CC1(C)CN(C(=O)c2ccc(-n3ccnn3)cc2)CCS1(=O)=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=Cc1cc(F)c(OCC(=O)N2CCCCCC2)c(F)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(S(=O)(=O)N2CCN(C(=O)c3ccc(N(C)C)cc3)CC2)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCCc1nn(C)c2c1NC(=O)C(CC)(CC)N2 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NS(=O)(=O)c1ccc(CCNC(=O)CCC2=c3ccccc3=[NH+]C2)cc1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C#CCOc1ccccc1/C=C(\C#N)C(=O)[O-] ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC[C@@H](O)C[NH2+]C Fragment 2: [16*]c1cccc2ccccc12 ### Response: C[NH2+]C[C@H](O)COc1cccc2ccccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(CNC(=O)[C@H]1C[C@@H]1c1ccc(F)cc1)NC(=O)OC(C)(C)C ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CCOCCN1C(=O)NCc1ccc(-n2ccnc2)nc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(CN2C(=O)CCCC2=O)(CCC1)CS ### Response: O=C1CCCC(=O)N1CC1(CS)CCCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CS(=O)(=O)c1ccc(NC(=O)N2C[C@H](O)[C@@H](N3CCOCC3)C2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2nc3s/c(=C\c4ccco4)c(=O)n3c2-c2ccc(OC)cc2)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2nc(C[NH+]3CCN(Cc4ccc(F)cc4)C(=O)C3)c(C)o2)cc1C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-c2nn(-c3ccccc3)cc2C(=O)N[C@@H]2CCCNC2=O)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CS(=O)(=O)c1ccccc1C(=O)Nc1nc(-c2ccc([N+](=O)[O-])cc2)cs1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(CC[NH+]1Cc1ccc(cc1)O[C@@H](C(=O)OC)C)c1n[nH]c(n1)C ### Response: COC(=O)[C@@H](C)Oc1ccc(C[NH+]2CCC(c3n[nH]c(C)n3)CC2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccc(F)c(F)c1F)c1cc2c(s1)CCC2 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1(C)[C@H]2OCCC[C@H]2[C@@H]1OC(=O)c1ccc(-c2cscn2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(=S)N[C@H]1CCCc2c1cnn2C Fragment 2: [4*][C@@H](C)c1ccccc1 ### Response: C[C@H](NC(=S)N[C@H]1CCCc2c1cnn2C)c1ccccc1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCC1=NN(c2cc(F)c(F)c(F)c2)C(=O)C1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCC([15*])CC1 Fragment 2: [14*]c1nc2ccccc2o1 ### Response: O=C(CNC(=O)N1CCC(c2nc3ccccc3o2)CC1)N1CCCCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(F)F Fragment 2: [7*]C(S[11*])C(=O)[O-] ### Response: O=C([O-])/C(=C\c1ccc(OC(F)F)cc1)Sc1nnc(-c2ccc(F)cc2)o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CS[11*] Fragment 2: [4*]CCS[11*] ### Response: CCn1cc[nH+]c1[C@@H]1CCCN(C(=O)CSCC[NH+]2CCCC2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(c(C(C)C)cc2[nH]ncc12)O ### Response: CC(C)c1cc2[nH]ncc2cc1O
canonicalization
### Instruction: Canonicalize the following SMILES string. C([NH+]1CCC[C@@H](C1)COC)c1sc2C[C@@H](C)CCc2n1 ### Response: COC[C@H]1CCC[NH+](Cc2nc3c(s2)C[C@@H](C)CC3)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NC2CC[NH+](CC(S(=O)(C)=O)(C)C)CC2)cccc1 ### Response: CC(C)(C[NH+]1CCC(Nc2ccccc2)CC1)S(C)(=O)=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)c1cccc(-c2cnc(Cl)cc2C(=O)[O-])c1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NCCNC([C@@H]1C=c2c(=[NH+]1)cccc2)=O)C(N1CCN(c2c(cccc2)OC)CC1)=O ### Response: COc1ccccc1N1CCN(C(=O)C(=O)NCCNC(=O)[C@@H]2C=c3ccccc3=[NH+]2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1cccc(-c2n[nH]c3c2CN(C(=O)CCc2ccncc2)CC3)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]N1CC[S@@](=O)C(C)(C)C1 ### Response: CC(C)CN1CCO[C@@H](CNC(=O)CN2CC[S@@](=O)C(C)(C)C2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(F)ccccc1O[C@@H](C)CNC(=O)c1nn(c(cc1)=O)CC ### Response: CCn1nc(C(=O)NC[C@H](C)Oc2ccccc2F)ccc1=O
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1ccc(CNC(=O)N[C@H]2C[C@H](C)N(c3ccccc3)C2=O)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[NH2+][C@H](Cc1ncnn1C)C1([NH+]2CCCC2)CCCC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1c(C)nc(-n2nc(C)cc2NC(=O)c2ccco2)nc1[O-] ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [4*][C@@H](C)c1ccc(C#N)cc1 ### Response: CCc1cccc(C)c1NC(=O)C[NH+](CC)[C@@H](C)c1ccc(C#N)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCOCC(=O)N[C@@H]1CCCC[C@@H]1OC1CCCC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1[C@@H](C)CC(=O)N1CCc2ccc([N+](=O)[O-])cc2C1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCc1ccsc1)c1csc(C#CCO)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? CCSc1nc(=O)c2c([nH]1)NC1=C(C(=O)CC(C)(C)C1)[C@@H]2c1cccc(OC)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c([nH]cc2/C=N/n2c(nnc2C)C)c(ccc1)CC ### Response: CCc1cccc2c(/C=N/n3c(C)nnc3C)c[nH]c12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[S@@](=O)[C@@H]1CCC[C@H](NC(=O)N2CCSCC2)C1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(CN1CC[NH+](Cc2cccc(O)c2)CC1)Nc1ccncc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](C(=O)Nc1cccc2ccccc12)[NH+]1CCNC(=O)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(CSc1oc2ccccc2n1)N/N=C\c1cc(cc(Br)c1[O-])Br ### Response: O=C(CSc1nc2ccccc2o1)N/N=C\c1cc(Br)cc(Br)c1[O-]
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H]2C[C@H](C1)C[C@H]2CNc1nc(ncc1F)Cl ### Response: Fc1cnc(Cl)nc1NC[C@@H]1C[C@H]2CC[C@@H]1C2
functional_group
### Instruction: Does the molecule contain a ester group? O=C1OC[C@H](Cc2ccccc2)N1CN1CCN(c2ccc(F)cn2)CC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC([4*])(C)C Fragment 2: [4*][C@H](C)c1c(C)noc1C ### Response: Cc1noc(C)c1[C@@H](C)NC(=O)NCC(C)(C)NS(C)(=O)=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H]1CCCCN1C(=O)COc1ccc(Br)cc1Br ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H]1C[C@H]1C(=O)Nc1cccc(C(=O)NCC(C)(C)c2cccs2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CCCN1[5*] Fragment 2: [5*]NCc1ccc([16*])cc1 ### Response: COc1ccccc1Oc1ccc(CNC(=O)[C@@H]2CCCN2C(=O)C2CCCC2)cc1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCCCN(CC)C(=O)CNC(=O)c1ccc2c(c1)OCO2 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCC[NH2+]Cc1cncc(N2CCC(C)(CC)CC2)n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? C/C(=C\c1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1C ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@]1(C(=O)N/N=C/c2cccs2)CC1(Br)Br ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(-c2nc(CC(=O)NC3(C#N)CCCCC3)cs2)c1 ### Response: 2