task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2n(ccc2cc1)Cc1[nH]nc(c1)C(=O)N1CCC[C@H]1CO ### Response: O=C(c1cc(Cn2ccc3ccccc32)[nH]n1)N1CCC[C@H]1CO
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(C(N2C[C@@H](CCC2)CCC(NCc2c(cccc2)F)=O)=O)CCOCC1 ### Response: O=C(CC[C@@H]1CCCN(C(=O)C2CCOCC2)C1)NCc1ccccc1F
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COc1cc(C)c([C@H](C)NC(=O)C[C@H]2CCCO2)cc1OC ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(NC(=O)[C@@H]2CCCN(C(=O)c3ccc(Cl)cc3)C2)c(F)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCCC1=CCCCC1)N1CCN(C(=O)c2ccncc2)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C([S@@](=O)CC[NH+]1Cc1oc(-c2sccc2)nn1)(C)C ### Response: CC1(C)C[NH+](Cc2nnc(-c3cccs3)o2)CC[S@@]1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc([16*])c(F)c1 Fragment 2: [1*]C(=O)C[8*] ### Response: COc1ccc(CC(=O)N2CCN(c3ccc(C(C)=O)cc3F)CC2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C)ccc1-c1csc2nc([nH]c(c12)=O)COC ### Response: COCc1nc2scc(-c3ccc(C)cc3)c2c(=O)[nH]1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](NC(=O)c1ccc(F)c(F)c1F)C(N)=S ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [11*]Sc1nc([14*])nc2cc(=O)[nH]n12 ### Response: CCOc1ccc(-c2nc(SCC(=O)Nc3cc(C)cc(C)c3)n3[nH]c(=O)cc3n2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1nc(Br)c2c(N[C@@H]3CCS(=O)(=O)C3)ncnc21 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@@H]1CN(C(=O)[C@@H](C)S(=O)(=O)c2ccc(F)cc2)CCO1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c([C@@]2(CC)NC(=O)N(C2=O)CC(=O)NCCc2ccc(Cl)cc2)ccc(F)c1 ### Response: CC[C@]1(c2ccc(F)cc2)NC(=O)N(CC(=O)NCCc2ccc(Cl)cc2)C1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nn(C)cc1[C@H](C)[NH2+]C1C(C)(C)C1(C)C ### Response: 1
functional_group
### Instruction: Does the molecule contain a thiol group? CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)c3nccc4ccccc34)C2)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C(N(Cc2nnc(n2C)C2CC2)C)=O)ccc2c(OC(C)(C2)C)c1O ### Response: CN(Cc1nnc(C2CC2)n1C)C(=O)c1ccc2c(c1O)OC(C)(C)C2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2CCN(C(NC[C@@H]3OC[C@H]4CCCCN4C3)=O)Cc2cc1Cl ### Response: O=C(NC[C@H]1CN2CCCC[C@@H]2CO1)N1CCc2ccc(Cl)cc2C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(OC)c(O)c1 Fragment 2: [4*]CCCl ### Response: COc1ccc(C(=O)N(CCCl)C2CCCCC2)cc1O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCc1noc(CC)n1 Fragment 2: [5*]Nc1ncnc2sc(C)c(C)c12 ### Response: CCc1nc(CCNc2ncnc3sc(C)c(C)c23)no1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C[NH+]2CCN([C@H](C)C(N)=O)CC2)ccc1F ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1/C(=C/c2cc(Cl)c([O-])c(Cl)c2)C([O-])=NC(=S)N1c1ccc(F)cc1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCNC(=O)CNC(=O)c1cn(-c2ccc(Cl)cc2)nc1C ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. n12cc(CSc3ccc(C(=O)NCC[NH+]4CCC(C)CC4)cc3)nc1cccc2 ### Response: CC1CC[NH+](CCNC(=O)c2ccc(SCc3cn4ccccc4n3)cc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nn(C[C@@H]2Cc3ccccc3S2)cc1C[NH3+] ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1c(NC(=O)CCl)nc2ccccc21 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Cn1c(-c2cscn2)nc2ccccc21)NC[C@@H]1CCCO1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1C[C@H](C)CN(C(=O)COC(=O)c2cccc(S(=O)(=O)N3CCc4ccccc43)c2)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1nncs1)N(Cc1cccc(F)c1)C1CC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)/C=C/C(=O)Nc1cc(C)cc(C)c1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1c(-c2cccc3ccccc23)nn(CN2CCOCC2)c1=S ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1sccc1C Fragment 2: [1*]C(=O)C1CC1 ### Response: Cc1ccsc1[C@@H](O)CNC(=O)C1CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1occc1C(=O)/C(C#N)=C/c1ccc([C@@H]2C[C@H]2C)o1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(CNc2ncnc3ccc(F)cc23)c1O ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? O=C1C[C@H](c2nc(-c3cccnc3)no2)CN1c1cccc(Cl)c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOc1ccc([C@@H]2c3c(oc4cc(C)cc(C)c4c3=O)C(=O)N2C[C@H]2CCCO2)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NNC(=O)c1c(Cl)cccc1)c1ccc(COc2ccc(Cl)cc2)cc1 ### Response: O=C(NNC(=O)c1ccccc1Cl)c1ccc(COc2ccc(Cl)cc2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc([C@H]([NH2+]CC2(N(C)C)CCOCC2)C2CC2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1C[C@H]2CCCC[NH+]2C[C@H]1[13*] Fragment 2: [4*]C[C@@H]1CCS(=O)(=O)C1 ### Response: CC(C)[C@@H]1C[NH+]2CCCC[C@@H]2CN1C[C@@H]1CCS(=O)(=O)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])CN(C)C(=O)c2cccs2)c1C ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCCC1 Fragment 2: [1*]C(=O)CC ### Response: CCC(=O)N(C)c1ccccc1C(=O)N[C@H](C)c1nc(C2CCCC2)no1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1[C@H]1C(C(=O)c2ccc(Cl)cc2)=C([O-])C(=O)N1c1nc(C)c(C)s1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCC1([NH+]2CCCCC2)CCCC1)[C@@H]1CCC(=O)N(C2CCCCCC2)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CC)[NH2+][C@@H]1CCC[C@@H]1CCN1CCn2cnnc2C1 ### Response: CCC[NH2+][C@@H]1CCC[C@@H]1CCN1CCn2cnnc2C1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1ccn(C)c(=O)c1NC(=O)C(=O)N1CC[C@H]2OCCC[C@@H]2C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ketone group? CC[NH+]1CCN(CC(=O)N[C@@H]2CCC[C@@H]2c2ccccc2C(F)(F)F)CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(NC(=O)N2C[C@@H]3CC[C@H](C2)N(Cc2cscn2)C3=O)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? CCCNC(=O)c1sc(C)nc1C ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccc(CN2CCOCC2)cc1)c1ccccc1F ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(NC(=O)[C@@H]1C[C@H]2CC[C@@H]1O2)c1ccc([N+](=O)[O-])cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NS(=O)(=O)c2c(cccc2)F)cccc1C#N ### Response: N#Cc1cccc(NS(=O)(=O)c2ccccc2F)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(NC(=O)C[NH+](C)CC(=O)Nc2ccccc2)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a phenol group? CN(CC(=O)OCc1ccccc1F)S(=O)(=O)c1cccnc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ncnc2ccc(F)cc12 Fragment 2: [14*]c1nnc([14*])n1CC ### Response: CCn1c(CC[NH3+])nnc1Sc1ncnc2ccc(F)cc12
functional_group
### Instruction: Does the molecule contain a ether group? COc1cc(/C=C2/SC(=O)N(c3ccc(C)c(C)c3)C2=O)ccc1OCCC(=O)[O-] ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccccc1C(=O)NCCc1ccccc1F ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aldehyde group? CCOC(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)C1 ### Response: No
functional_group
### Instruction: Does the molecule contain a phenol group? CN(Cc1nccn1Cc1ccccc1)C(=O)[C@@H]1C[C@H]1c1cccc(F)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CNS(=O)(=O)[C@H]1CCOC[C@@H]1Cc1c(F)cccc1Cl ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ccc(S(=O)(=O)N(C)CC(=O)N2CCCCCC2)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC(C)(C)c1ccc(OC[C@H](C)C[NH3+])cc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(Br)c1 Fragment 2: [8*][C@H](CCl)CCS(=O)(=O)CC ### Response: CCS(=O)(=O)CC[C@@H](CCl)c1cccc(Br)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccnc(O[3*])c1 Fragment 2: [5*]N1CCOc2cc(F)ccc21 ### Response: O=C(c1ccnc(OC2CCC2)c1)N1CCOc2cc(F)ccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1cccs1)N1CC[C@@H](Oc2cccc(Cl)c2)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@@H](Nc1cc(CO)ccc1)C)(NC(CC)CC)=O ### Response: CCC(CC)NC(=O)[C@H](C)Nc1cccc(CO)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccc(N)cc1OC Fragment 2: [4*]CCS[11*] ### Response: COc1cc(N)ccc1SCC[NH+]1CCCC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nn(C)cc1[C@H](C)[NH2+]C1C(C)(C)C1(C)C ### Response: 0
functional_group
### Instruction: Does the molecule contain a nitro group? CC[C@@H]1CCCCN1C(=O)Cc1ccc([N+](=O)[O-])cc1[N+](=O)[O-] ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(Cc2noc([C@@H](n3cccn3)C)n2)c1)F ### Response: C[C@@H](c1nc(Cc2ccc(F)cc2)no1)n1cccn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](NC(=S)N1CCN(Cc2ccc3c(c2)OCO3)CC1)C12CC3CC(CC(C3)C1)C2 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(CN(C)C(=O)CN2CCC[NH+](CC(=O)N(C)C)CC2)o1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ncoc1[14*] Fragment 2: [16*]c1ccccc1Cl ### Response: CC(C)c1ocnc1C[S@@](=O)CC(=O)N[C@H](C)c1ccccc1Cl
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1Nc2cc(F)ccc2S(=O)(=O)N1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: CC(=O)c1ccc(N2CCN(C(=O)[C@@H]3Nc4cc(F)ccc4S(=O)(=O)N3)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1ccccc1 Fragment 2: [5*]NS(=O)(=O)c1ccccc1 ### Response: COc1cccc(-c2nnc(NC(=O)c3ccccc3NS(=O)(=O)c3ccccc3)o2)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [9*]n1c[nH+]cc1[14*] ### Response: COC(=O)[C@@H](C(C)C)[C@@H](O)c1c[nH+]cn1C1CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Cc1ccc(Cl)cc1)N(Cc1ccccc1)c1ccccn1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCCOc1ccc(-c2nnc(C[NH+]3CC[C@H](C)[C@H](O)C3)o2)cc1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@H]1C(=O)NCC[NH+]1Cc1ccc(O)c(Cl)c1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)OCCNC(N[C@H]1CCC[C@H](C1)[S@@](CC)=O)=O)Cl ### Response: CC[S@@](=O)[C@@H]1CCC[C@H](NC(=O)NCCOc2ccc(Cl)cc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(/c1cc(C)ccc1)=C/C(=O)OCCNC(=O)c1ccncc1 ### Response: Cc1cccc(/C=C\C(=O)OCCNC(=O)c2ccncc2)c1
functional_group
### Instruction: Does the molecule contain a amine group? COc1cc(=O)n2c(c1C(=O)NCc1ccsc1)CC[NH+](Cc1ccc(C(C)C)cc1)CC2 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C1[C@@H](NC(N1Cc1ccc(cc1)-n1cccn1)=O)C(C)C ### Response: CC(C)[C@@H]1NC(=O)N(Cc2ccc(-n3cccn3)cc2)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1C[C@@H]1c1ccc(/C=C/C(=O)N(C)CCCS(C)(=O)=O)o1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCc1ccccc1 Fragment 2: [1*]C(=O)[C@@H]1C=C(c2ccccc2O)N=N1 ### Response: O=C(NCc1ccccc1)C1=C2CCCC[C@@H]2S[C@@H]1NC(=O)[C@@H]1C=C(c2ccccc2O)N=N1
functional_group
### Instruction: Does the molecule contain a nitrile group? CC[C@@H](NC(=O)c1ccc(C)c(F)c1)c1nc(C(F)(F)F)cs1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitrile group? COc1ccccc1N1CCN(C(=O)C(=O)NCCNC(=O)[C@@H]2C=c3ccccc3=[NH+]2)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? Cc1cc(NC(=O)N(C)[C@@H](C)c2ccco2)ccc1-n1cnnn1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [1*]C(=O)c1cc([14*])nn1C ### Response: Cn1nc(C(C)(C)C)cc1C(=O)Nc1ccc(CNC(N)=O)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)C[C@@H](C)Nc1nc(C(F)(F)F)ccc1C(N)=O ### Response: 5
functional_group
### Instruction: Does the molecule contain a aldehyde group? CCNC(=O)NCCOCC(F)(F)F ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(N2C(=O)CC[C@@H](C(=O)Nc3ccc(C(=O)NC4CC4)cc3)[C@@H]2c2cccs2)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1CCCO1 Fragment 2: [1*]C(=O)CC[8*] ### Response: C[C@@H](OC(=O)CC[C@@H]1CCCO1)c1ccc(Cl)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cn1nnc(-c2ccccc2)n1)OC1CCCCC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1C[C@@H]([15*])C2(CCOCC2)C1 Fragment 2: [4*]Cc1ccco1 ### Response: O=C([O-])[C@@H]1C[NH+](Cc2ccco2)CC12CCOCC2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCn1c(=O)c(C(=O)CN2CCN(C(=O)c3ccco3)CC2)c(N)n(Cc2ccccc2)c1=O ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C1CC[NH+](CC[C@@H](O)c2ccc(C)c(F)c2)CC1)CC ### Response: CCOC1CC[NH+](CC[C@@H](O)c2ccc(C)c(F)c2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(NC(=O)NCc2ccccc2Oc2nccnc2)CCC[C@H](CC)C1 ### Response: CC[C@H]1CCC[C@H](NC(=O)NCc2ccccc2Oc2cnccn2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](O)(Cc1oc2ccccc2n1)c1c(cc(cc1)Cl)OC ### Response: COc1cc(Cl)ccc1[C@H](O)Cc1nc2ccccc2o1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1n[nH]c([14*])n1 Fragment 2: [8*][C@@H](C)[NH3+] ### Response: C[C@@H]([NH3+])c1n[nH]c(-c2ccc(I)cc2)n1
functional_group
### Instruction: Does the molecule contain a thiol group? CCn1cnnc1CNC(=O)c1cccc(F)c1Cl ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC[C@H]1C[C@@H]1NC(=O)CNC(=O)NC ### Response: 0