task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C[NH+]2CCC(c3nnc(Cn4cncn4)n3C)CC2)s1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1cc(C(=O)NCCc2ccccc2)c(C(=O)[O-])n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? COS(=O)(=O)c1ccc(Cl)c2ccccc12 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc2oc(=O)cc(CN3CCC4(CC3)NC(=O)N(C)C4=O)c2cc1C ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1csc(c1)C(=O)N(C)CC(=O)O[C@H]1C[C@H](CCC1)OC ### Response: CO[C@H]1CCC[C@@H](OC(=O)CN(C)C(=O)c2cccs2)C1
functional_group
### Instruction: Does the molecule contain a ether group? C[C@H](CO)[C@H](C)Nc1nccc(OCc2ccccc2)n1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a halide group? O=C1C[C@@H](NC2=NS(=O)(=O)c3ccccc32)CN1CC(F)(F)F ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1CC[C@@H]([NH+](CC(=O)N(C)C)CC(F)(F)F)C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCNc1nnc(SCCS(=O)(=O)c2ccc(Br)cc2)s1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(Nc1ccccc1C(=O)N)[C@H]1C(=CN=N1)I ### Response: NC(=O)c1ccccc1NC(=O)[C@@H]1N=NC=C1I
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)(C)c1nn(c(C(=O)N[C@H](c2ncccc2)c2ccccc2)c1)C ### Response: CC(C)c1cc(C(=O)N[C@@H](c2ccccc2)c2ccccn2)n(C)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(C)c1OCC(=O)NCCc1c[nH]c2ccccc12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC[C@H]([NH2+]C)[C@@H]1CCc2cccnc21 Fragment 2: [3*]Oc1ccccc1 ### Response: C[NH2+][C@@H](CCOc1ccccc1)[C@@H]1CCc2cccnc21
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CCc2c1cn[nH]2)C(/C=C/SCc1occc1)=O ### Response: O=C(/C=C/SCc1ccco1)N1CCc2[nH]ncc2C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(N[5*])nn1 Fragment 2: [4*][C@@H](COC)C(C)C ### Response: COC[C@H](Nc1ccc(C(=O)N(C)C)nn1)C(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CCC Fragment 2: [5*][NH2+][C@@]1([15*])CC[C@@H]([15*])C1 ### Response: CCC[NH2+][C@@]1(C(=O)[O-])CC[C@@H](N2CC[NH+](C)CC2)C1
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1ccccc1NC(=O)c1nnc([C@@H]2CCCN(S(=O)(=O)c3ccc(F)c(Cl)c3)C2)s1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(CCO[C@H](C)C1)[C@H](c1c(Cl)cccc1F)CNC(=O)N[C@H]1[C@@H](C)C1 ### Response: C[C@@H]1CN([C@@H](CNC(=O)N[C@@H]2C[C@@H]2C)c2c(F)cccc2Cl)CCO1
canonicalization
### Instruction: Canonicalize the following SMILES string. N#C/C(=C\c1cc(O)c(OC)cc1)S(=O)(c1ccc(cc1)C)=O ### Response: COc1ccc(/C=C(\C#N)S(=O)(=O)c2ccc(C)cc2)cc1O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)C(=O)[C@@H](C)NS(=O)(=O)c1cccc(Br)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? COc1cnc(F)c(C(=O)[O-])c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(S(=O)(=O)NCC2CC[NH2+]CC2)sc1Br ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C(C(N2CCN(CC2)c2ccccc2)=O)CCN(S(=O)(Cc2ccccc2Cl)=O)C1 ### Response: O=C(C1CCN(S(=O)(=O)Cc2ccccc2Cl)CC1)N1CCN(c2ccccc2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. O1CCC[C@H]1CNC(c1/c(=[NH+]/c2cc(F)c(OC)cc2)oc2c(cccc2c1)OC)=O ### Response: COc1ccc(/[NH+]=c2\oc3c(OC)cccc3cc2C(=O)NC[C@@H]2CCCO2)cc1F
functional_group
### Instruction: Does the molecule contain a amide group? CC[NH+](CCNC(=O)N[C@H]1CC(=O)N(C(C)(C)C)C1)C(C)C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1F Fragment 2: [4*]Cc1ccc2c(c1)OCO2 ### Response: O=C(COc1ccccc1F)N1CCN(Cc2ccc3c(c2)OCO3)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COC(=O)c1ccc(NC(=O)CSc2ncc(C(F)(F)F)cc2Cl)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? NC(=O)N[C@@H](CC(=O)NNC(=O)c1ccc2c(c1)OCO2)c1ccccc1Cl ### Response: 3
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CC(C)CCNC(=O)c1cccc(S(=O)(=O)N[C@@H]2CCCNC2=O)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cn(c(c(n1-c1c(cccc1C)C)=O)=O)Cc1onc(n1)-c1cc(F)ccc1 ### Response: Cc1cccc(C)c1-n1ccn(Cc2nc(-c3cccc(F)c3)no2)c(=O)c1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccccc1[C@H]1CCCN(C(=O)c2cnc(-c3cccnc3)nc2)C1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC[C@@H](C(=O)N1CCN(c2cc(Cl)ccc2C)CC1)n1nc(C)n2c(cc3occc32)c1=O ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+](C)[C@H]1CC[C@@H](NC(=O)N2CCC(NC(=O)c3ccccc3F)CC2)C1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? ClCc1nc2cccnc2n1CCc1cccs1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a amide group? CN(Cc1ccno1)Cc1c(C(=O)N2CC[NH+](C3CCCCC3)CC2)nc2ccccn12 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC=C Fragment 2: [4*]CCc1ccccc1 ### Response: C=CCn1c(N2CC[NH+](CCc3ccccc3)CC2)nc2c1c(=O)[nH]c(=O)n2C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH+](CC(=O)NC)Cc1c[nH]nc1-c1cccnc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitrile group? COc1ccc2[nH]cc(CC(=O)Nc3cccc(N(C)C(C)=O)c3)c2c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1cnccn1)N1CCCC[C@@H]1[C@H]1CCCC[C@@H]1O ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? Cc1cccc(NC(=S)NNC(=O)c2ccncc2)c1C ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C(=O)[C@@H](C)S[C@H](C)[C@@H](C)O)c(C)n1Cc1ccco1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc2c(c1)sc(=S)n2CN1C[C@H](C)O[C@@H](C)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC Fragment 2: [4*]CCC ### Response: CCCNC(=O)N1[C@@H](C(=O)[O-])CC[C@H]2CCCC[C@@H]21
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1c(=O)n2c(n(c1C)CC(=O)N1CCCC[C@@H]1C)nc(-c1ccc(cc1)C)n2)c1ccccc1 ### Response: Cc1ccc(-c2nc3n(CC(=O)N4CCCC[C@@H]4C)c(C)c(Cc4ccccc4)c(=O)n3n2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1cccc1[C@H](CNC(=O)C(=O)Nc1ccc(Cl)cc1)[NH+]1CCOCC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. FC(F)(c1cc([C@H]2CN(C(c3nc(ncc3)C)=O)CCC2)n[nH]1)F ### Response: Cc1nccc(C(=O)N2CCC[C@@H](c3cc(C(F)(F)F)[nH]n3)C2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(COc2ccc(F)cc2)sc1C(=O)Nc1ccc2c(c1)NC(=O)[C@H](C)O2 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](Oc1ccccc1F)C(=O)NNC(=O)c1ccc(Cl)c(Cl)c1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccccc1CN(C(=S)Nc1ccc(Cl)cc1C)C1CC[NH+](C)CC1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#CCc1ccc(NC(=O)[C@@H]2CC(=O)N(CC3CC3)C2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12nc(C3CC[NH+](Cc4ccco4)CC3)oc2ccc(c1)Cl ### Response: Clc1ccc2oc(C3CC[NH+](Cc4ccco4)CC3)nc2c1
functional_group
### Instruction: Does the molecule contain a nitro group? O=C1N[C@@](Cc2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc([N+](=O)[O-])cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]Sc1nnc([14*])n1C Fragment 2: [5*]Nc1ccc([16*])cc1 ### Response: CN(C)c1ccc(NC(=O)CSc2nnc(-c3cccnc3)n2C)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@H](C[NH+](CC)CC)CN1Cc1c(O)cc(OC)cc1 ### Response: CC[NH+](CC)C[C@@H]1CCN(Cc2ccc(OC)cc2O)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOC(=O)c1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](SCCOc1cccc(Cl)c1)C(N)=O ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(Cl)c(C)cc1NCC(=O)Nc1cc(OC)c([N+](=O)[O-])cc1C ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNC(=O)[C@@H]1CCCN(S(=O)(=O)c2c(C)nn(CC(=O)NC(C)(C)C)c2C)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NC[C@H]1C[C@@H](O)C[NH+]1Cc1ccccc1)c1n[nH]c2c1CCCC2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? CN1C(=O)c2cccc(NC(=O)Cc3ccc(F)cc3)c2C1=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [5*]NCc1ccccc1[16*] ### Response: CC(C)[NH+](C)Cc1ccccc1CNC(=O)N(C)Cc1ccc(F)cc1F
canonicalization
### Instruction: Canonicalize the following SMILES string. c1([C@H](C(=O)OCC(=O)Nc2cc(Cl)ccc2)CC)ccccc1 ### Response: CC[C@@H](C(=O)OCC(=O)Nc1cccc(Cl)c1)c1ccccc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CNC(=O)c1ccc(Cl)c(NC(=O)[C@H]2C=C[C@@H]([NH3+])C2)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2nc(C)cc(C(=O)N(C)Cc3ccccc3)c2c1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCn1c(S[C@@H](C)C(=O)N[C@@H](C)c2ccccc2)nc2ccc(Br)cc2c1=O ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1nnnn1[C@H]1CC(=O)[C@@H]2OC[C@H]1O2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? CCn1c(SCC(=O)N(C)C2CCOCC2)nnc1-c1ccco1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(C([C@@H](CCC1)[NH2+][C@H]1CCCc2c1cnn2C)=O)CC(F)(F)F ### Response: Cn1ncc2c1CCC[C@@H]2[NH2+][C@@H]1CCCN(CC(F)(F)F)C1=O
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#C[C@H](COC(=O)c1cccc(Br)c1)Cc1cccs1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(Br)ccc1NC(=O)[C@@H]1CC=CCC1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(=O)cc(OC)c(c2CCN(C(=O)C3(CC3)c3ccccc3)CCn12)C(N(C)Cc1nonc1C)=O ### Response: COc1cc(=O)n2c(c1C(=O)N(C)Cc1nonc1C)CCN(C(=O)C1(c3ccccc3)CC1)CC2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N(C(C)C)C(=O)c1cnn(c1C(F)F)CC(C)C)[C@H]1CCCCO1 ### Response: CC(C)Cn1ncc(C(=O)N(C[C@H]2CCCCO2)C(C)C)c1C(F)F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@H](O)COC Fragment 2: [5*][NH+]1CCC([15*])CC1 ### Response: COC[C@@H](O)C[NH+]1CCC(N[C@@H]2CCCc3ccc(Cl)cc32)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccccc1F Fragment 2: [1*]C(=O)c1cc(S([12*])(=O)=O)ccc1OC ### Response: CCN(CC)S(=O)(=O)c1ccc(OC)c(C(=O)Nc2ccccc2F)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](CC(=O)Nc1c(F)cccc1Br)c1ccccc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(-c2cnc3c(c2)CN(C(=O)c2ccc4c(c2)OCCO4)CC3)cc1OC ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCN(C1)C(c1sc2c(c1)c(n(c(n2C)=O)C)=O)=O ### Response: Cn1c(=O)c2cc(C(=O)N3CCCC3)sc2n(C)c1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1c(c(on1)CC)CNC(c1c(ccc(SC)c1)[N+]([O-])=O)=O)C ### Response: CCc1noc(CC)c1CNC(=O)c1cc(SC)ccc1[N+](=O)[O-]
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccccc1N1C[C@H]2C[C@@H]1C[NH2+]2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? CC[C@H]1CCCC[C@H]1N(C)C(=O)c1ccc2c(c1)NC(=O)CN2CC ### Response: No
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1cc(C)c(S(=O)(=O)Oc2ccc(NC(=O)c3ccco3)cc2)c(C)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)C1=C(CC)[C@H](C(=O)OCC)C(C)=N1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(NNc1cccnc1Cl)c1cccn1Cc1ccccc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCC[S@@](=O)C(C)(C)C Fragment 2: [16*]c1ccccc1C#N ### Response: CC(C)(C)[S@](=O)CCNC(=O)c1ccccc1Sc1ccccc1C#N
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(Cc1ccncc1)[C@@H]1/C(=N/O)[C@H]2CC[C@@H]1C2 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nn(C)cc1C(=O)N[C@@H](C)c1c(Cl)ccc(F)c1Cl ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=C(c1cc(F)cc(Br)c1)N1CCCC[C@H]1CCO ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(S(=O)(=O)[C@H]2CCCC(C)(C)[C@H]2[NH3+])c(C)c1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Clc1cccc(CC[NH2+]Cc2cc[nH]c2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Cc1csc(-c2ccccn2)n1)NCC1(c2ccccc2)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. CC[NH+]1C[C@@H](Cn2c(N)nc3c2nccc3C)CC1 ### Response: CC[NH+]1CC[C@H](Cn2c(N)nc3c(C)ccnc32)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])CCCNS(=O)(=O)c1cc(C(F)(F)F)ccc1Cl ### Response: 4
functional_group
### Instruction: Does the molecule contain a amide group? O=C(Cn1cnc2c(oc3ccccc32)c1=O)NC(=O)NCc1ccco1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(OC)c(OC)c1 Fragment 2: [3*]OCc1cc(F)cc2c1O[C@H]([13*])OC2 ### Response: COc1ccc(C(=O)OCc2cc(F)cc3c2O[C@H](c2ccccc2)OC3)cc1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)CCC(=O)[O-] Fragment 2: [16*]c1ccccc1 ### Response: C[C@H](CNS(=O)(=O)CCC(=O)[O-])c1ccccc1
canonicalization
### Instruction: Canonicalize the following SMILES string. s1c(ncc1)CCN(C(=O)Nc1cncc2ccccc12)CC ### Response: CCN(CCc1nccs1)C(=O)Nc1cncc2ccccc12
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCN([5*])CC1 Fragment 2: [1*]C(=O)CCCS(=O)(=O)C[8*] ### Response: O=C(CCCS(=O)(=O)Cc1ccccc1)N1CCN(c2ccccc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1CNC(=O)C1(Cc2cc(-c3ccccc3C)no2)CCOCC1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(C2(C(=O)NC[C@](C)(O)c3cccs3)CCOCC2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a halide group? NC(=O)CCN1CCN(C(=O)c2cn(C/C=C/c3ccccc3)nn2)CC1 ### Response: No