task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCN(C)S(=O)(=O)N[C@@H](c1ccc(OC)cc1)C1CCOCC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)cc(NC(=O)CSc2nc3c(oc4ccccc43)c(=O)n2C(C)C)c1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1C[C@]2(C)[C@@H](CC[C@H]3[C@@H]2CC[C@]2(C)[C@H](O)CC[C@@H]32)C/C1=N\N ### Response: 1
functional_group
### Instruction: Does the molecule contain a nitro group? CC[C@@H](C)C[NH+]1CCCN(C(=O)CCc2ccc(OC)cc2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1C[C@H]1C Fragment 2: [3*]OCC[4*] ### Response: C[C@@H]1C[C@H]1C(=O)OCCN(C)S(=O)(=O)N1CCOCC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)[C@@H](/C=N/NC(N)=O)C(=O)NC1=S Fragment 2: [16*]c1ccccc1 ### Response: NC(=O)N/N=C/[C@H]1C(=O)NC(=S)N(c2ccccc2)C1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)Nc1ccc(Sc2ccc([N+](=O)[O-])cc2C#N)cc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CSC[C@H](C)C(=O)NCc1ccccc1CN1CCOCC1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? COc1c(C)cnc(CNC(=O)Nc2ccc(N(C)C)cc2)c1C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CCn1ccc([16*])c1 Fragment 2: [13*][C@@H]1CCCO1 ### Response: C[C@@H]([NH3+])c1ccn(CC[C@@H]2CCCO2)c1
functional_group
### Instruction: Does the molecule contain a nitro group? COC(=O)C1(NC(=O)c2ccc(Cl)cc2Cl)CCCC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C([O-])[C@H]1CCCN(C(=O)CCOc2ccc(F)cc2)C1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [1*]C(=O)C[4*] ### Response: C[C@H](NC(=O)CSc1nnc2ccccn12)C1CC1
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1ccc(NC(=O)[C@H]2CS[C@]3(C)CCC(=O)N23)cc1[N+](=O)[O-] ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH2+][C@H](c1ccc(OCC)cc1Br)[C@@H]1COCCO1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1CC(NC(=O)NC[C@H](C)c2nc(-c3ccccc3)no2)C1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. O1CCOc2c1cc(cc2)C(=O)N1CCC(CC1)[C@H]1C(=CN=N1)CCc1ccccc1 ### Response: O=C(c1ccc2c(c1)OCCO2)N1CCC([C@@H]2N=NC=C2CCc2ccccc2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Nc1cc(C(=O)Nc2c(F)cccc2F)ccc1F ### Response: 0
functional_group
### Instruction: Does the molecule contain a ketone group? Cc1csc([C@H](C)NC(=O)N[C@H]2CCCC2(C)C)n1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aldehyde group? CCN1C(C(=O)c2ccccc2)=C(N(C)C)c2ccccc2S1(=O)=O ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [1*]C(=O)c1nc2c(=O)oc3ccccc3c2n(C)c1=O ### Response: CCOC(=O)c1nc2c(=O)oc3ccccc3c2n(C)c1=O
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1ccc(CN(C(=O)C[S@@](=O)c2ncccc2Cl)C2CC2)o1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1C[C@@H](C)C[C@H](C)C1 Fragment 2: [1*]C(=O)NNC(=O)C[8*] ### Response: C[C@H]1C[C@H](C)C[NH+](C[C@@H](C)NC(=O)NNC(=O)Cc2c[nH]c3ccccc23)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(C)C Fragment 2: [1*]C(=O)[C@H]1CCC[NH+]1[5*] ### Response: CC(C)OC(=O)[C@H]1CCC[NH+]1C(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1CCCO1 Fragment 2: [1*]C(=O)[C@H]1COc2ccc(F)cc2C1 ### Response: CC[C@H](NC(=O)[C@H]1COc2ccc(F)cc2C1)[C@@H]1CCCO1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=c1[nH]c(=O)c(CCNc2nc(-c3cccnc3)nc(c2)C)c[nH]1 ### Response: Cc1cc(NCCc2c[nH]c(=O)[nH]c2=O)nc(-c2cccnc2)n1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(CC)c1ccc(CNC(=O)N2CCN(C(=O)N(C)C)CC2)cc1F ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)(C)NC(=S)NC(=O)/C=C/c1ccccc1Cl ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C(CCS(=O)(c1ccc(cc1)C)=O)[NH+]1CCC[C@H](C1)C ### Response: Cc1ccc(S(=O)(=O)CCC[NH+]2CCC[C@@H](C)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[NH+]1CCC(CNC(=O)N[C@@H](C)c2ccc(-n3cccn3)cc2)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1nnc(S[11*])n1C Fragment 2: [16*]c1c(C)nc2cc(C)ccn2c1=O ### Response: CCc1cccc(NC(=O)CSc2nnc(Cc3c(C)nc4cc(C)ccn4c3=O)n2C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCC(CC)(CC)C1 Fragment 2: [13*][C@@H]1CCCO1 ### Response: CCC1(CC)CC[NH+](CC[NH2+][C@H](C)[C@@H]2CCCO2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cc(C)[nH]n1 Fragment 2: [1*]C(=O)C[8*] ### Response: Cc1cc(CC(=O)N[C@@H]2CCCC[C@@H]2OCCC(C)C)n[nH]1
functional_group
### Instruction: Does the molecule contain a nitro group? C[NH2+][C@@]1(C(N)=O)CC[C@H](Oc2cccc([N+](=O)[O-])c2C)C1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCCn1nnc2ccccc21)c1cccc2ccnn12 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1csc2[nH+]c(CN3CCC[C@@H](C(=O)Nc4cnccn4)C3)cc(=O)n12 ### Response: 3
functional_group
### Instruction: Does the molecule contain a thiol group? C[C@H]1CCC[NH+](C[C@H](O)CN2CCOCC2)C1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccc(Cl)cc1)Nc1ncn[nH]1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cncn1 Fragment 2: [5*]N1CCC[C@H]1[13*] ### Response: O=C(NCc1ccc(-n2cncn2)cc1)N1CCC[C@H]1C1CCCCC1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1nc(C2CCN(C(=O)Nc3ccc([S@@](C)=O)c(F)c3)CC2)no1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1([NH3+])CCC1 Fragment 2: [5*]NCCCO ### Response: [NH3+]C1(CC(=O)NCCCO)CCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(Cl)ccc1-n1c(c(Cl)c(cn1)N1CCc2sccc2C1)=O ### Response: O=c1c(Cl)c(N2CCc3sccc3C2)cnn1-c1ccc(Cl)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(Cc1nc2ccccc2c(=O)[nH]1)C(=O)c1csc(S(=O)(=O)N2CCc3ccccc3C2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1CC[NH+](CCCNC(=O)NCc2ccc(Cl)nc2)CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCOc1ccc2nc(SCC(=O)Nc3ccc(SC)cc3)sc2c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? N#CC1=C(N)Oc2cc3c(cc2[C@H]1c1ccccc1OCc1ccccc1Cl)OCO3 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc(C)c(NC(=O)c2cc3ccccc3n2C)c(C)c1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(S(NC2CCN(C([C@@H]3CN(C(=O)C3)c3cccc(Cl)c3)=O)CC2)(=O)=O)ccc(OC)c1 ### Response: COc1ccc(S(=O)(=O)NC2CCN(C(=O)[C@H]3CC(=O)N(c4cccc(Cl)c4)C3)CC2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-n2ccnc(SCC(=O)Nc3cc(Cl)ccc3C)c2=O)cc1C ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccccc1F)[C@@H]1C[C@H]2CC[C@@H]1C2 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1cc(C)cc(N(CCC#N)C(=O)[C@H](C)Sc2ncnc3c2cnn3C)c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1ccccc1 Fragment 2: [1*]C(=O)C[7*] ### Response: CNS(=O)(=O)c1cc(NC(=O)/C=C/c2ccccc2)ccc1OC
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H](Oc1ccc(Cl)cc1N1C(=O)[C@@H]2[C@@H](C1=O)[C@H]1C=C[C@@H]2C1)C(=O)c1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(=O)NNc1ncnc2[nH]cnc12 Fragment 2: [16*]c1ccc(CC)cc1 ### Response: CCc1ccc(C(=O)NNc2ncnc3[nH]cnc23)cc1
functional_group
### Instruction: Does the molecule contain a nitrile group? CCO/C=C1\SC(=O)N=C1N1N=C(c2ccccc2)C[C@@H]1c1ccc(Cl)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc(NC(=O)/C=C/c2cc(F)cc3c2OCOC3)c1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [4*]Cc1ccccc1 ### Response: O=C(CN1CCO[C@@H](c2cccs2)C1)NOCc1ccccc1
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1cccnc1C[C@@H](N[C@H]1CCSc2ccccc21)C(F)(F)F ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCCCN1c1ccc(NC(=O)c2nccnc2N)c(C(N)=O)c1 ### Response: NC(=O)c1cc(N2CCCCC2)ccc1NC(=O)c1nccnc1N
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(NC(=O)NC[C@H](O)c2c(Cl)cccc2Cl)cn1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCOc1ccc(C[NH+](C)Cc2ccc(OC)c(O)c2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC#N Fragment 2: [3*]OC[C@@H](O)C[4*] ### Response: N#CCc1ccc(OC[C@@H](O)C[NH+]2CCc3cncnc3C2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(cc(cc1)-c1noc(n1)CS[C@H](C)[C@@H](O)C)OCO2 ### Response: C[C@H](O)[C@@H](C)SCc1nc(-c2ccc3c(c2)OCO3)no1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1occc1C(=O)NC1CC[NH+](Cn2nc(-c3ccccc3)oc2=S)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [4*][C@H](C)C(=O)C1=c2ccccc2=[NH+][C@H]1C ### Response: C[C@@H]1[NH+]=c2ccccc2=C1C(=O)[C@@H](C)S[C@@H]1NN=C(c2ccccc2F)N1C1CC1
functional_group
### Instruction: Does the molecule contain a halide group? C[NH+](C)[C@H](CNC(=O)[C@@H]1Cc2ccccc2O1)c1ccc(F)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)c(O)c(C(=O)Nc2ccccc2N2CCOCC2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COc1ccc(Cl)cc1)N1CCN(C(=O)c2ccco2)CC1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cnc([C@@H](C)NC(=O)N2CCC[C@@H]3CCC[C@@H]32)s1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? COc1ccccc1[C@@H](C)NC(=O)[C@H](C)Sc1cccc2cccnc12 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCCS[C@@H](C)C(=O)NCc1cn2cc(Cl)ccc2n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCC[C@H](O)C(C)C Fragment 2: [16*]c1ccccc1 ### Response: CC(C)[C@@H](O)CCNC(=O)NCc1nc(-c2ccccc2)cs1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COc1ccc(OCC2CCN(C(=O)C(C)(C)n3cncn3)CC2)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(-c2nn(c(o2)=O)CC(=O)N2[C@H](c3cc4c(OCCO4)cc3)CCC2)ccc(cc1)F ### Response: O=C(Cn1nc(-c2ccc(F)cc2)oc1=O)N1CCC[C@H]1c1ccc2c(c1)OCCO2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)(C)[C@H]1CCc2c(sc(NC(=O)CSc3nnnn3-c3ccccc3)c2C#N)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@@H]([8*])C(C)C Fragment 2: [4*][C@H](C)c1ccc(C)o1 ### Response: Cc1ccc([C@@H](C)N[C@@H](c2nc(C3CC3)no2)C(C)C)o1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC1(C)CC[C@H](CNC(=O)[C@@H]2CCOC2)c2ccccc21 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitrile group? CCCCS(=O)(=O)N1CCN(S(=O)(=O)c2ccc3ccccc3c2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]C1C(=N)N2N=C(C(F)(F)F)SC2=NC1=O Fragment 2: [7*]C/C=C1\N(C)c2ccccc2C1(C)C ### Response: CN1/C(=C\C=C2\C(=N)N3N=C(C(F)(F)F)SC3=NC2=O)C(C)(C)c2ccccc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cnn([9*])c1 Fragment 2: [1*]C(=O)[C@H](N[5*])C(C)C ### Response: CCCn1cc(NC(=O)[C@H](NC(C)=O)C(C)C)cn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)N1CCC[C@@H]1[13*] Fragment 2: [5*]NCc1ncnn1C ### Response: Cn1ncnc1CNC(=O)N1CCC[C@@H]1c1ccc2c(c1)OCO2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1C=C(Nc2ncn[n-]2)C[C@@H](c2ccc(Cl)cc2)C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC(=O)[O-] Fragment 2: [3*]OC1([15*])CCCCC1 ### Response: O=C([O-])COC1(Cc2ccccc2)CCCCC1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CC[NH2+][C@H](CCC)C1)c1cc(C)n(CCOC)c1C ### Response: CCC[C@@H]1CN(Cc2cc(C)n(CCOC)c2C)CC[NH2+]1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CN(CC(=O)O[C@H]1CCCc2ccccc21)C(=O)c1ccc(Br)o1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](C)[NH2+]CCc1n[nH]c(-c2ccco2)n1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a thiol group? N#CCC(=O)/N=C1\S[C@@H]2CS(=O)(=O)C[C@H]2N1c1ccc(Br)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [5*]N(C)C[8*] ### Response: CN(Cc1cccs1)C(=O)[C@@]1(C)Oc2ccc(Cl)cc2NC1=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(F)(F)F Fragment 2: [1*]C(=O)C[4*] ### Response: O=C(C[NH+]1CCCNCC1)Nc1ccc(OC(F)(F)F)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)-n1c(C)cc(n1)C)[C@H](C)NC(=O)[C@H]1CCCN(C1)C(=O)N ### Response: Cc1cc(C)n(-c2ccc([C@H](C)NC(=O)[C@H]3CCCN(C(N)=O)C3)cc2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C)c([C@H](C)NC(=O)[C@@H](NC(=O)c2ccccc2Br)C(C)C)c1 ### Response: 4
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc[nH]c1C(=O)Nc1c(ccc(c1)F)C(N[C@@H](C)C(OC)=O)=O ### Response: COC(=O)[C@H](C)NC(=O)c1ccc(F)cc1NC(=O)c1ccc[nH]1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)C1=C(C)N(CCc2cccs2)C(=O)N[C@H]1c1cccc(C#N)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a nitro group? CC(C)[NH+]1CCC[C@@H](CNC(=O)CCOC2CCOCC2)C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1ccc2[nH]c([C@H]3Cc4ccccc4S3)nc2n1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN/C(=[NH+]\CCOC)N(C)Cc1ccccc1Cl ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C([O-])[C@@H]1CCCN1C(=O)c1cccc(S(=O)(=O)N2CCCCC2)c1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=S1(=O)C[C@@H](O)[C@H](/N=C/c2ccoc2)C1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[8*] Fragment 2: [8*]CSC ### Response: COc1ccc(C2(NC(=O)Cn3c(CSC)nc4ccccc43)CCCC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CCCC1(C)C Fragment 2: [15*][C@H]1CCCNC(=O)C1 ### Response: CC1(C)CCC[C@H]1[NH2+][C@H]1CCCNC(=O)C1