task
stringclasses
5 values
input
stringlengths
89
339
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)C[C@H](NC(=O)C[C@H]1OCCc2ccccc21)C1CC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)[C@@H]1CCOc2ccccc21 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCO[C@H](C)C1 Fragment 2: [1*]C(=O)C[4*] ### Response: C[C@@H]1CN(C2CC[NH+](CC(=O)Nc3ccccc3)CC2)CCO1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CCN(c1ccc(C(=O)N(C)C)cc1)S(C)(=O)=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]Nc1cc([14*])no1 ### Response: CCCC1=NC(SCC(=O)Nc2cc(C(C)(C)C)no2)=NC(=O)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)[C@@H]1CCCN1Cc1ccccc1OCC(F)(F)F ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCCCN1CCCC1=O)c1cc2scnc2[nH]1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@H]1CCS(=O)(=O)C1 Fragment 2: [5*]N1CCN([5*])CC1 ### Response: O=C([C@H]1CCS(=O)(=O)C1)N1CCN(Cc2ccon2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1CCC=C2C[C@H]3OC(=O)[C@H](C[NH+]4CCN(C(=O)c5ccco5)CC4)[C@H]3[C@H](O)[C@@]21C ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C1C[C@@H](CCN1C)C(N[C@@H](CCc1ccc(OC(C)C)cc1)C)=O ### Response: CC(C)Oc1ccc(CC[C@@H](C)NC(=O)[C@@H]2CCN(C)C(=O)C2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1[nH]c2c(C)ccc(C)c2c1CC(=O)N(C)CCCc1cnn(C)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? C=C[C@H]1C[NH+]2CC[C@@H]1C[C@@H]2CNC(=O)C1CCCCC1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? CCOC(=O)c1cnn([C@@H]2CCCN(C(=O)NC[C@H](C)c3ccsc3)C2)c1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)C[C@H](CNC(=O)c1ccc(O)cc1O)C(=O)[O-] ### Response: 1
functional_group
### Instruction: Does the molecule contain a carboxyl group? O=C(Nc1ccccc1N1CCCCC1)[C@@H]1CC(c2ccc(Cl)s2)=NO1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NC[C@H]1CCCCN1c1ncnc2c1oc1ccccc12)c1ccccc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H](C)n1cc(I)cn1 Fragment 2: [3*]OCC ### Response: CCO[C@H](C)n1cc(I)cn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccn2cc(CC(N)=S)[nH+]c12 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(F)c(F)ccc1[C@H](N[C@@H](c1ccc(-n2cncc2)cc1)C)COC ### Response: COC[C@@H](N[C@H](C)c1ccc(-n2ccnc2)cc1)c1ccc(F)c(F)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC[C@H](O1)c1nnc(NC(=O)c2cc3c(cccc3)cc2OC)o1 ### Response: COc1cc2ccccc2cc1C(=O)Nc1nnc([C@@H]2CCCO2)o1
canonicalization
### Instruction: Canonicalize the following SMILES string. Brc1ccc(cc1)OCCOC(=O)c1cc[n+](cc1)[O-] ### Response: O=C(OCCOc1ccc(Br)cc1)c1cc[n+]([O-])cc1
functional_group
### Instruction: Does the molecule contain a amide group? O=C1Nc2ccccc2C[C@@H]1CCC(=O)N1CCc2ccc(Cl)cc2C1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCC(=O)Oc1cccc([N+](=O)[O-])c1C ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc(C)c(C)o1 Fragment 2: [1*]C(=O)C([1*])=O ### Response: Cc1nc(-c2cccc(NC(=O)C(=O)N[C@@H](C)[C@@H]3CCCO3)c2)oc1C
functional_group
### Instruction: Does the molecule contain a halide group? O=C(CN1C(=O)/C(=C\c2ccccc2F)SC1=S)N[C@@H]1C=CS(=O)(=O)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccnn1 Fragment 2: [16*]c1ccc(S(=O)(=O)NC)cc1 ### Response: CNS(=O)(=O)c1ccc(CCc2nc(-c3cccnn3)no2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(C(=CN(C)c2ccccc2)S(=O)(=O)c2ccc(C)cc2)cc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1nn(C)cc1NC(=O)C(=O)N1CCN([C@@H](CC)CO)CC1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1nnc2n1CCCC2)N1CC[C@]2(CCCN(CC3CC3)C2=O)C1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(cc1)NC(C(C)C)=O)NC(=O)NCCc1c(F)cc(F)cc1 ### Response: CC(C)C(=O)Nc1cccc(NC(=O)NCCc2ccc(F)cc2F)c1
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cn1nc(Br)c2c(N[C@@H](CO)[C@@H](O)c3ccc([N+](=O)[O-])cc3)ncnc21 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(/C=C2\Oc3c(ccc(O)c3C[NH+]3CCC(C)CC3)C2=O)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a thiol group? N#Cc1ccc(OCC(=O)Nc2ccccc2N2CCc3ccccc32)cc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC(=S)N[5*] Fragment 2: [1*]C(=O)C(C)C ### Response: CC(C)C(=O)NC(=S)Nc1ccc2oc(-c3ccc(C(C)C)cc3)nc2c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])C(=S)S Fragment 2: [4*]C(C)C ### Response: CC(C)N(C(=S)S)C(C)C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cnn(C)c1C Fragment 2: [14*]c1n[nH]c(C)n1 ### Response: Cc1nc(-c2cccc(NCc3cnn(C)c3C)c2)n[nH]1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1nc2ccccc2[nH]1)c1ccc(CS(=O)(=O)c2ccccc2)o1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N[C@@H]1CCCC[C@@H]1[15*] Fragment 2: [8*]C(F)(F)F ### Response: Cc1cccc(C(=O)N[C@@H]2CCCC[C@@H]2C(F)(F)F)n1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(OCc1cc([N+](=O)[O-])cc2c1OCOC2)c1cnc2ccccc2n1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](C(N)=O)n1c(CCCl)nc2cccnc21 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NC(CSc2n(-c3c(OC)ccc(C)c3)nnn2)=O)cc(cc1C)C ### Response: COc1ccc(C)cc1-n1nnnc1SCC(=O)Nc1cc(C)cc(C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccccc1Cl Fragment 2: [1*]C(=O)c1nn(C)cc1Cl ### Response: Cn1cc(Cl)c(C(=O)OCC(=O)Nc2ccccc2Cl)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CC[NH+](Cc2ncccc2C)CC1)c1ccc(cc1)Cl ### Response: Cc1cccnc1C[NH+]1CCN(Cc2ccc(Cl)cc2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)cc(OCCCSC2[NH+]=c3ccccc3=[NH+]2)ccc1 ### Response: Cc1cccc(OCCCSC2[NH+]=c3ccccc3=[NH+]2)c1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1cc(C)c(NC(=O)N(C)CC(=O)Nc2cccc(Cl)c2)c(C)c1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. O(C)CCN1CCN(CC1=O)C(=O)NC[C@H]([NH+](C)C)c1ccc(cc1)Cl ### Response: COCCN1CCN(C(=O)NC[C@@H](c2ccc(Cl)cc2)[NH+](C)C)CC1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CNS(=O)(=O)[C@@H]1CCOC[C@@H]1Cc1cccc(F)c1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH2+][C@@H](Cc1ccc(CC)s1)[C@@H]1CSCCS1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C[C@@H]1CCN(C(=O)C(=O)Nc2cccc3ncccc23)C[C@@H]1O ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. N([C@H](C)c1ccccc1)c1c(c(n2c(n1)ccc(c2)C)=O)/C=C1/C(=O)N([C@@H](CC)C)C(S1)=S ### Response: CC[C@@H](C)N1C(=O)/C(=C/c2c(N[C@H](C)c3ccccc3)nc3ccc(C)cn3c2=O)SC1=S
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CCOCC1)(C)(C)[C@H]([NH2+]C)c1ccc(cc1)CCC ### Response: CCCc1ccc([C@@H]([NH2+]C)C(C)(C)N2CCOCC2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cnc(OC)c(CN2C(=O)CNC([C@H]2C2CC2)=O)c1 ### Response: COc1ncccc1CN1C(=O)CNC(=O)[C@H]1C1CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCCC(=O)Nc1ccc(C)cc1NC(=O)[C@H]1C=CC[NH2+]1 ### Response: 5
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(-n2cnnn2)cc1NC(=O)[C@@H]1C=C[C@@H]([NH3+])C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1CC(=O)N[C@](C)(CC)C1=O Fragment 2: [8*]Cc1cc(C)c(F)c(C)c1 ### Response: CC[C@@]1(C)NC(=O)CN(Cc2cc(C)c(F)c(C)c2)C1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Fc1cc(F)c(F)c(CN[C@H]2CCc3sc(Cl)cc32)c1F ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(Cl)ccc1NC(=O)CSc1nnc(C(C)C)n1N ### Response: 3
functional_group
### Instruction: Does the molecule contain a halide group? Cn1cc[nH+]c1C[C@](O)(C[NH3+])C(F)(F)F ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)c1ccc(NC(=O)[C@@H]2CCC[NH+]2Cc2ccccc2)cc1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? COc1cccc(C2=[NH+][C@@H](c3ccccc3)C(=S)N2)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a ketone group? O=C1[C@H]2CC=CC[C@H]2C(=O)N1c1nc2n(n1)[C@@H](c1ccccc1)C[C@@H](c1ccc(Cl)cc1)N2 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCC[8*] Fragment 2: [16*]c1cccc([N+](=O)[O-])c1 ### Response: O=C(NCCc1cccc([N+](=O)[O-])c1)c1cc2occc2[nH]1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc([N+](=O)[O-])c1C Fragment 2: [1*]C(=O)N[5*] ### Response: Cc1c(NC(=O)N2CCC[C@@H](C)[C@@H]2CO)cccc1[N+](=O)[O-]
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@H](C)[C@H]1CC[C@H]([NH2+]C)C1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a halide group? CN(C(=O)CCCn1ccnn1)[C@H](c1ccc(Cl)cc1)C(F)(F)F ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CC)c1ncnc(Cl)c1[N+](=O)[O-] ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [5*]N[C@H]1CCC[C@@H]1[15*] ### Response: CCOc1ccccc1O[C@H]1CCC[C@@H]1NC(=O)c1ccc(OC)nc1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C[C@H]1C[C@@H]1C(=O)N1CCN(CC2=Cc3ccccc3OC2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(S([12*])(=O)=O)cc1 Fragment 2: [1*]C(=O)CC ### Response: CCC(=O)Nc1ccc(S(=O)(=O)N2CC[C@@H](C)[C@H](O)C2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[NH+]([5*])C Fragment 2: [16*]c1c(O)ccc2ccccc12 ### Response: CC(C)NC(=O)C[NH+](C)Cc1c(O)ccc2ccccc12
functional_group
### Instruction: Does the molecule contain a phenol group? CC(C)[NH2+]Cc1ccc(O[C@@H](C)C(N)=O)cc1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1[nH]c2ccccc2c1[C@@]1(O)C(=O)N(C/C=C/c2ccccc2)c2ccccc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(-n2c(nc3c(c2=O)cnn3-c2c(cccc2)Cl)-c2ccco2)c1)OC ### Response: COc1ccc(-n2c(-c3ccco3)nc3c(cnn3-c3ccccc3Cl)c2=O)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H]([C@H](CCC1)NC(=O)COC(=O)c1ccc(O)cc1)C ### Response: C[C@H]1CCCC[C@@H]1NC(=O)COC(=O)c1ccc(O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [6*]C(C)=O Fragment 2: [16*]c1cccc(S(=O)(=O)/N=c2\[nH]cccc2[16*])c1 ### Response: CC(=O)c1cccc(S(=O)(=O)/N=c2\[nH]cccc2-c2ccccc2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1C[C@H](C)C[NH+](CCC(=O)Nc2ccc(N3CCCC3=O)cc2)C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1ccccc1SC[C@H]1CCCO1)N1CCN([C@@H]2CCS(=O)(=O)C2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]CC(=O)NNc1cc(C#N)cc(Cl)n1 Fragment 2: [3*]OC(C)C ### Response: CC(C)Oc1ccccc1CC(=O)NNc1cc(C#N)cc(Cl)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(=O)c(C(=O)N2CCN(c3ccccc3)CC2)nc2cccnc21 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. N(c1ccc(cc1)/C=C/C(=O)OCC)C(C(C)(F)C)=O ### Response: CCOC(=O)/C=C/c1ccc(NC(=O)C(C)(C)F)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [16*]c1c(C)n[nH]c1[O-] ### Response: Cc1n[nH]c([O-])c1[C@H](c1c(C)[nH][nH]c1=O)[C@H]1CN(Cc2ccccc2)c2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)N(C[C@H]1C[C@@H]1C)C(=O)NCC[NH+]1CCCCC1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cc(F)cc(C(=O)NCc2cccnc2-n2cccn2)c1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc([C@@H](NC([C@H](C)Cc2c(C)[nH]nc2C)=O)c2ccc(F)cc2)ccc1 ### Response: Cc1n[nH]c(C)c1C[C@@H](C)C(=O)N[C@H](c1ccccc1)c1ccc(F)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCCNC(=O)[C@@H]1CCCN(c2ccc3nnnn3n2)C1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a carboxyl group? COc1cc([C@H]([NH3+])C(=O)[O-])cc(I)c1OC ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc([14*])nn1C Fragment 2: [14*]c1cc([14*])n(C)n1 ### Response: CCCc1cc(NC(=O)N(CC)C2CCCCC2)n(C)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1CCCCC1 Fragment 2: [1*]C(=O)c1ccc([16*])cc1 ### Response: CN1CCN(S(=O)(=O)Cc2ccc(C(=O)NC3CCCCC3)cc2)CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc([C@@H](O)[C@H](C)[NH2+][C@H](C)c2ccc(C)s2)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CO[C@H](C)C(=O)Oc1ccc(Br)cc1Br ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1Nc2c(c(=O)oc3ccccc23)[C@H](c2cccc([N+](=O)[O-])c2)N1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CCN(CC1)c1cc2c(cc1NC(Nc1ccccc1F)=O)n(C)c(n2C)=O ### Response: Cn1c(=O)n(C)c2cc(N3CCCCC3)c(NC(=O)Nc3ccccc3F)cc21
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)c1ccc(NC(=O)[C@@H]2C[C@@H]2[N+](=O)[O-])s1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCCC1 Fragment 2: [16*]c1cccnc1 ### Response: Cn1cc(CNc2cccc(CC[NH+]3CCCC3)c2)c(-c2cccnc2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(nc2n(c1NCCOC1CCCCCC1)ncn2)C ### Response: Cc1nc2ncnn2c(NCCOC2CCCCCC2)c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2nc(CC(=O)NCCS(N)(=O)=O)cs2)o1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? O=C(Nc1ccccc1Cl)C(c1ccccc1)c1ccccc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccn2ccnc2c1 Fragment 2: [5*]N1CCc2c([nH]c3ccccc23)C1 ### Response: O=C(c1ccn2ccnc2c1)N1CCc2c([nH]c3ccccc23)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)n1ncc2cc(C(=O)NC[C@@H](c3cccs3)N3CCOCC3)cnc21 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)(O)CNC(=O)c1c(F)ccc([N+](=O)[O-])c1F ### Response: 3