task
stringclasses
5 values
input
stringlengths
89
339
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N[C@@H](C(=O)OC)CC)c1cc2c(cc1)n(cn2)C(C)C ### Response: CC[C@@H](NC(=O)c1ccc2c(c1)ncn2C(C)C)C(=O)OC
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CC(CCC1)[C@H](C)NC(=O)[C@@H](C)CC(c1ccccc1F)=O ### Response: C[C@H](NC(=O)[C@@H](C)CC(=O)c1ccccc1F)C1CCCCC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](NC(=O)[C@@H]1CCCO1)c1nc2ccccc2n1CC(=O)N1CCCCCC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(nccnc1Oc1ccc(OC)cc1)C1CCN(CC1)C(=O)CC ### Response: CCC(=O)N1CCC(c2nccnc2Oc2ccc(OC)cc2)CC1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cccc(C(=O)N(C)[C@H](C)c2ccc(S(C)(=O)=O)cc2)c1[N+](=O)[O-] ### Response: 0
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@H](OC(=O)[C@@H]1CCS(=O)(=O)C1)C(=O)Nc1ccc2c(c1)CCC2 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? CC[C@H](NC(=O)Nc1ccc(S(N)(=O)=O)cc1)c1ccc(Cl)cc1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)N1C(CCC1)=O)NC(=O)N(CC)CC1CC1 ### Response: CCN(CC1CC1)C(=O)Nc1ccc(N2CCCC2=O)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1cccc([16*])c1 Fragment 2: [9*]n1ccnc1 ### Response: Brc1cnc(NCc2cccc(Cn3ccnc3)c2)nc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1cc(CN2CCOCC23CCC3)c(-c2ccncc2)n1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C=CCN(Cc1nc(-c2ccccc2)no1)S(=O)(=O)c1ccc(Br)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(N2CCN(CC2)c2ccc(cc2)F)ccc(NC(=O)CCC([O-])=O)cc1 ### Response: O=C([O-])CCC(=O)Nc1ccc(N2CCN(c3ccc(F)cc3)CC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(C)c(N)cn1 Fragment 2: [1*]C(=O)c1cc(C)c(Br)s1 ### Response: Cc1cc(NC(=O)c2cc(C)c(Br)s2)ncc1N
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCCCCC1 Fragment 2: [1*]C(=O)c1cc([14*])on1 ### Response: CC(C)c1cc(C(=O)N2CCCCCC2)no1
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(c1cn(Cc2ccc(F)cc2)nc1OCc1ccc(F)cc1)N1CCCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [1*]C(=O)C([1*])=O ### Response: COc1ccc(F)c(NC(=O)C(=O)NC[C@H](O)c2ccco2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOc1ncccc1C(=O)Nc1ccc(C(=O)NC)cc1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nnc(NC(=O)N[C@H]2CCCC[C@H]2C)s1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1cc2ccccc2n2c(=O)n(C[C@H](C)NC(=O)CCCn3cncn3)nc12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*][NH+]1CCn2c([14*])nnc2C1 Fragment 2: [8*]C(F)(F)F ### Response: Cc1ccc(C[NH+]2CCn3c(nnc3C(F)(F)F)C2)s1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(Cl)ccc1[C@H](C#N)NS(=O)(c1ccc(cc1)[N+]([O-])=O)=O ### Response: N#C[C@H](NS(=O)(=O)c1ccc([N+](=O)[O-])cc1)c1ccc(Cl)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1cccc(-c2nnnn2C2CC2)c1)c1ccc(Br)s1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H](C)O[3*] Fragment 2: [3*]Oc1ccc(C)cc1 ### Response: Cc1ccc(O[C@H](C)C(=O)Nc2ccc(S(=O)(=O)N3CCCC3)cc2)cc1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1cc(C(=O)NCCCc2ccccc2)cn1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(CC)([C@@H]1CSCCN1CC1(CS)CCCC1)=O ### Response: CCS(=O)(=O)[C@@H]1CSCCN1CC1(CS)CCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1ccc(F)cc1F)N(CC(F)(F)F)c1ccccn1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[NH+](C)CC(=O)N1CCN(C(=O)CCc2nc3ccccc3n2-c2ccccc2)CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CCO[3*] Fragment 2: [1*]C(=O)CC[4*] ### Response: Cc1csc([C@@H](C)NC(=O)CCOc2ccccc2)n1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H]([C@H](CC)C)CC[C@@H]1[NH2+]C ### Response: CC[C@H](C)[C@H]1CC[C@H]([NH2+]C)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)C[8*] Fragment 2: [16*]c1ccc([16*])c(OC)c1 ### Response: COc1cc(CN(C)C(=O)c2sc(-c3ccsc3)nc2C)ccc1OC(F)F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)C[NH+](Cc1ccc(C(=O)[O-])cn1)C1CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OC(F)F Fragment 2: [3*]O[C@@H]1CCN([5*])C1 ### Response: Fc1cc(CN2CC[C@@H](Oc3cc[nH+]cc3)C2)ccc1OC(F)F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)c1ncnc2[nH]cnc12 Fragment 2: [4*]CC1CCC(C)CC1 ### Response: CC1CCC(CN(C)c2ncnc3[nH]cnc23)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@H]1CSCCS1 Fragment 2: [4*][C@H]([8*])[C@H]1CSCCS1 ### Response: CC[NH2+][C@H](c1cc(Cl)cnc1N)[C@H]1CSCCS1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cccc(N2CC[NH+](Cc3nc(Cc4ccccc4)no3)CC2)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? CCOc1ncnc(NNC(=O)c2cccnc2)c1N ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COCCN1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)CC1=O ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCCn1c(NC(=O)Nc2ccccc2C#N)c2ccccc2nc1=O ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2c(C)nc(N3CCC[C@@H](C(=O)N[C@@H]4CS(=O)(=O)C[C@H]4O)C3)nc2c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)CNC(=O)c1cccnc1Sc1ccc(C)cc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? Cc1cn(-c2ccccc2Cl)nc1NC(=O)N1CCC[C@H]([C@@H](C)O)C1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CSc1cccc(NC(=O)[C@H]2CC=CCC2)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(CCS(C)(=O)=O)C(=O)Nc1ccccc1F ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(c(NC(=O)[C@@H]2N(C(=O)COC2)Cc2ccccc2)cncc1)OC ### Response: COc1ccncc1NC(=O)[C@H]1COCC(=O)N1Cc1ccccc1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cc(C)cc(CSCc2cc(=O)n3ccccc3n2)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [7*]Cc1ccc(OC)c(F)c1 ### Response: COc1ccc(/C=C/C(=O)N2CCC[NH+](Cc3ccccc3)CC2)cc1F
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CNC(=O)[C@H]1CCCC[C@@H]1[NH2+][C@@H]1CCCOc2cc(C)c(C)cc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c([C@@H]([NH3+])[C@@H](CC1)Sc1ncc(Br)cc1)cc(OC)cc2 ### Response: COc1ccc2c(c1)[C@@H]([NH3+])[C@H](Sc1ccc(Br)cn1)CC2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc([N+](=O)[O-])s1 Fragment 2: [6*]C(=O)[O-] ### Response: CO[C@@H]1C[C@H](C(=O)[O-])N(C(=O)c2ccc([N+](=O)[O-])s2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. N1(c2[nH+]cc(cc2)NC(=O)[C@@H]2C([C@@H]2C=C(C)C)(C)C)CCCC1 ### Response: CC(C)=C[C@@H]1[C@H](C(=O)Nc2ccc(N3CCCC3)[nH+]c2)C1(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. COc1ccc(N2CCN([C@@H](c3onc(n3)C(C)(C)C)C)CC2)cc1 ### Response: COc1ccc(N2CCN([C@H](C)c3nc(C(C)(C)C)no3)CC2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(F)c1)CN(C1CC1)C(=O)CC[C@@H]1C(=O)NC(N1)=O ### Response: O=C1NC(=O)[C@@H](CCC(=O)N(Cc2ccc(F)cc2)C2CC2)N1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@@H]1CCCCN1C(=O)Nc1ccc(C(N)=O)c(F)c1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a phenol group? COc1cc(NC(=O)c2ccc(-c3ccccc3Cl)o2)cc(OC)c1OC ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c([nH+]c3n2[C@@H](c2cnccc2)C2C(=O)CCCC=2N3)ccc1 ### Response: O=C1CCCC2=C1[C@H](c1cccnc1)n1c([nH+]c3ccccc31)N2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN1C(=O)[C@]2(NC(=O)c3cc(Cl)ccc3N2)c2ccc(F)cc21 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1c(C(=O)/C=C/c2cnn(C)c2)nnn1-c1ccccc1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a phenol group? CC(C)CN1C(N)=[NH+]C[C@@]1(C)c1ccc(O)cc1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [13*][C@@H]1NC(=S)NC(C)=C1C(=O)N/N=C/c1cccc(Br)c1 Fragment 2: [16*]c1ccc([N+](=O)[O-])cc1 ### Response: CC1=C(C(=O)N/N=C/c2cccc(Br)c2)[C@H](c2ccc([N+](=O)[O-])cc2)NC(=S)N1
functional_group
### Instruction: Does the molecule contain a amide group? O=C(CCNC(=O)[C@H]1CN(Cc2ccccc2)CCO1)Nc1ccccc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)C[NH2+]Cc1ccc(N2CC[NH+](C)CC2)nc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a sulfonyl group? CNS(=O)(=O)c1cc(C(=O)NCc2ccc3c(c2)OCCO3)ccc1OC ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(N2[C@@H]([C@H](c3nc4c([nH]3)cccc4)SC2=S)N)ccc(c1)OC ### Response: COc1ccc(N2C(=S)S[C@@H](c3nc4ccccc4[nH]3)[C@H]2N)cc1
functional_group
### Instruction: Does the molecule contain a nitro group? O=C(c1cccc(F)c1)N1CCCC[C@@H]1c1nc2c(c(=O)[nH]1)C[NH+](Cc1cccnc1)CC2 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH+](CC(=O)Nc1sc(C)c(C)c1C#N)CC(=O)NC(C)C ### Response: 0
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1ccc(-n2ccnc2)c(C(=O)N2CCN(C(=O)c3ccco3)CC2)c1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1cccc(C(=O)N[C@@H]2CCCN(c3ccc(F)cc3C)C2)c1F ### Response: 3
functional_group
### Instruction: Does the molecule contain a phenol group? O=C(NC[C@H](O)CO)Nc1ccccc1N1CCc2ccccc21 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(Nc1ccc(F)cc1Cl)c1ccccc1[N+](=O)[O-] ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(COc1ccc(Cl)c(Cl)c1)N1CCN(c2ccc(F)cc2)CC1 ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCc1nc(C)c([C@@H](C)N(C)C(=O)NCCc2ccc(C)cc2)s1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(NC(=O)[C@H]2Cc3cc(Cl)ccc3O2)sc1-c1nccn1C ### Response: 1
functional_group
### Instruction: Does the molecule contain a ketone group? CC(C)OCCN1CCN(C(=O)[C@H](C(C)C)N2C[C@@H](C)O[C@H](C)C2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C[C@@H]1C(=O)O[C@@H]2C[C@@]3(C)CCC[C@H](C)C3=C[C@H]12 Fragment 2: [5*][NH+]1CCSCC1 ### Response: C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)[C@@H](C[NH+]4CCSCC4)[C@H]3C=C12
functional_group
### Instruction: Does the molecule contain a hydroxyl group? COCCN1CCN(Cc2c(C)nn(-c3ccccc3)c2Cl)CC1=O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. CN(Cc1ccc(C)s1)S(c1nc(n(C)c1)C)(=O)=O ### Response: Cc1ccc(CN(C)S(=O)(=O)c2cn(C)c(C)n2)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? [NH3+][C@H]1CCCc2c(OCc3cc(F)cc(Br)c3)cccc21 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CCOc1ccc(NC(=O)N2CCOC[C@H]2C2CC2)cc1C ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC1(C)NC(=O)N(C[C@H](O)CN2CCN([C@@H]3CCS(=O)(=O)C3)CC2)C1=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a ketone group? CCc1noc(CC)c1CC(=O)N(c1ccc(C)cn1)C1CCCCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc2ncccc2c1 Fragment 2: [5*]N(C)CCCC=C ### Response: C=CCCCN(C)C(=O)c1ccc2ncccc2c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(CCNC(c2c(ccc(c2)N2C(CCC2)=O)Cl)=O)CCOC1 ### Response: O=C(NCCN1CCOCC1)c1cc(N2CCCC2=O)ccc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1ccc(Cl)c2c1nc(N1CCN(C(=O)c3ccc4ncsc4c3)CC1)s2 ### Response: Cc1ccc(Cl)c2sc(N3CCN(C(=O)c4ccc5ncsc5c4)CC3)nc12
functional_group
### Instruction: Does the molecule contain a amine group? CC(C)(C)Oc1cc(C(=O)Nc2ccc(N3CCC(C(N)=O)CC3)cc2)ccn1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(-c2c(c3nc4c(CN(C(Cn5nc(C)ccc5=O)=O)C4)c(n3n2)O)C)s1 ### Response: Cc1ccc(=O)n(CC(=O)N2Cc3nc4c(C)c(-c5cccs5)nn4c(O)c3C2)n1
functional_group
### Instruction: Does the molecule contain a carboxyl group? NC(=O)[C@@]1([NH3+])CCC[C@H]1CCSc1nc2ccccc2o1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc([C@H]2CCC(=O)O2)ccc1F ### Response: O=C1CC[C@H](c2ccc(F)cc2)O1
functional_group
### Instruction: Does the molecule contain a halide group? O=C(NCCc1cccs1)[C@H](Sc1ccccc1)c1ccccc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CC[C@H](N2CCN(C(=O)C(=O)N3CCOCC3)CC2)C1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CO)NC(=O)C(=O)Nc1ccc(-c2cn3ccsc3n2)cc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc(CC)ns1 Fragment 2: [5*]N1C[C@@H](C)[C@@H]1[13*] ### Response: CCc1nsc(N2C[C@@H](C)[C@@H]2c2ccccc2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCCn1nc(C(=O)NC23CC4CC(CC(C4)C2)C3)ccc1=O ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)N1CCN(Cc2c(O)ccc3c2O/C(=C/c2c(Cl)cccc2Cl)C3=O)CC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(N(C(=O)C(C)C)c2c(cccc2)[C@@]21N(C(C(C)C)=O)CCc1c2[nH]c2ccccc12)=O ### Response: CC(C)C(=O)N1C(=O)[C@@]2(c3ccccc31)c1[nH]c3ccccc3c1CCN2C(=O)C(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cccnc1)[C@H](N1CCCC1)C(=O)NCc1cn(nc1)-c1cc(ccc1)F ### Response: O=C(NCc1cnn(-c2cccc(F)c2)c1)[C@H](c1cccnc1)N1CCCC1
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1ccc2c(c1)C(=O)C[C@@]1(CCC(=O)N([C@@H](C)C(=O)NC[C@@H]3CCCO3)CC1)O2 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(/C=C/c2ccc(F)cc2)nc2ccc(I)cc2c1=O ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(C)cc(C)c1 Fragment 2: [3*]OCC ### Response: CCOC(=O)c1cn(CC(=O)Nc2cc(C)cc(C)c2)nn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1CCSc2ccc(Cl)cc21 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Nc1c2c(nc[n+]1CCO)Oc1cc(O)ccc1[C@H]2c1ccc(Cl)cc1 ### Response: 2